DESCRIPTION

Package: crmPack
Title: Object-Oriented Implementation of CRM Designs
Authors@R: c(
  person("Daniel", "Sabanes Bove", email = "daniel.sabanesbove@gmx.net", role = c("aut", "cre")),
  person("Wai", "Yin Yeung", email = "winnie.yeung@roche.com", role = "aut"),
  person("Giuseppe", "Palermo", email = "giuseppe.palermo@roche.com", role = "aut"),
  person("Thomas", "Jaki", email = "jaki.thomas@gmail.com", role = "aut"),
  person("Jiawen", "Zhu", email = "zhu.jiawen@gene.com", role = "aut"),
  person("Ziwei", "Liao", email = "ziwei.liao.fdu@gmail.com", role = "aut"),
  person("Dimitris", "Kontos", email = "dimitris.kontos@clinbay.com", role = "aut")
  )
Description: Implements a wide range of model-based dose
    escalation designs, ranging from classical and modern continual
    reassessment methods (CRMs) based on dose-limiting toxicity endpoints to
    dual-endpoint designs taking into account a biomarker/efficacy outcome. The
    focus is on Bayesian inference, making it very easy to setup a new design
    with its own JAGS code. However, it is also possible to implement 3+3
    designs for comparison or models with non-Bayesian estimation. The whole
    package is written in a modular form in the S4 class system, making it very
    flexible for adaptation to new models, escalation or stopping rules.
Version: 1.0.9000
License: GPL (>= 2)
URL: https://github.com/roche/crmPack
BugReports: https://github.com/roche/crmPack/issues
Depends:
    ggplot2 (>= 2.0.0),
    graphics,
    R (>= 3.0.0)
Imports:
    futile.logger,
    checkmate,
    lifecycle,
    GenSA,
    grid,
    gridExtra,
    MASS,
    methods,
    mvtnorm,
    parallel,
    rjags,
    survival,
    tools,
    utils
Suggests:
    testthat (>= 3.0.0),
    ggmcmc,
    knitr,
    Rcpp,
    RcppArmadillo,
    vdiffr
Roxygen: list(markdown = TRUE)
RoxygenNote: 7.1.2
Encoding: UTF-8
VignetteBuilder: 
    knitr
Copyright: F. Hoffmann-La Roche Ltd, except Google LLC for contributions by 
    Daniel Sabanes Bove between 6 August 2018 and 31 May 2020.
Language: en-US
LazyLoad: yes
Collate:
    'Data-validity.R'
    'helpers.R'
    'Data-class.R'
    'Data-methods.R'
    'Rules-validity.R'
    'Rules-class.R'
    'Model-validity.R'
    'helpers_jags.R'
    'Model-class.R'
    'Design-class.R'
    'McmcOptions-validity.R'
    'McmcOptions-class.R'
    'McmcOptions-methods.R'
    'Samples-class.R'
    'mcmc.R'
    'Simulations-class.R'
    'Model-methods.R'
    'Rules-methods.R'
    'Design-methods.R'
    'fromQuantiles.R'
    'Samples-methods.R'
    'Simulations-methods.R'
    'ZZ_IncrementsHSRBeta_DK.R'
    'ZZ_LogisticKadane2_DK.R'
    'ZZ_NextBestMTDCRM_DK.R'
    'ZZ_StoppingLowestDoseHSRBeta_DK.R'
    'ZZ_StoppingTargetProbPatientsNearHighestDose_DK.R'
    'ZZ_StoppingTargetProbPatientsNearLowestDose_DK.R'
    'ZZ_crmPack-package_DK.R'
    'crmPack-package.R'
    'logger.R'
    'utils.R'
    'x-source-bayer.R'
    'x_new_IncrementsHSRbeta.R'
    'x_new_StoppingLowestDoseHSRbeta.R'
    'y_bay_design_1GeneralSimulationsBay_summary.R'
    'y_bay_design_2GeneralSimulationsBay_show.R'
    'y_bay_design_3SimulationsBay_summary.R'
    'y_bay_design_BayDesign.R'
    'y_bay_design_BayDesign_examine.R'
    'y_bay_design_BayDesign_simulate.R'
    'y_bay_model_LogisticKadaneBayer.R'
    'y_bay_model_OneParExp.R'
    'y_bay_model_TwoPar.R'
    'y_bay_model_TwoParBayS.R'
    'y_bay_myfunction-outdated.R'
    'y_bay_myfunction.R'
    'y_bay_myfunction2.R'
    'y_bay_myproposal.R'
    'y_bay_rules_IncrementsAbsoluteMax.R'
    'y_bay_rules_IncrementsRelativeDLTmax.R'
    'y_bay_rules_IncrementsRelativeMax.R'
    'y_bay_rules_IncrementsSafetyStop.R'
    'y_bay_rules_IncrementsSafetyStopFix.R'
    'y_bay_rules_NextBestMTDprob.R'
    'y_bay_rules_NextBestMinDist.R'
    'y_bay_rules_StoppingHardFirst.R'
    'y_bay_rules_StoppingHardFirstFix.R'
    'y_bay_rules_StoppingMTDdistributionBay.R'
    'y_bay_rules_StoppingPatientsNearDose2.R'
    'y_bay_rules_StoppingProbBay.R'
Config/testthat/edition: 3