diff --git a/client/my-sites/plugins/plugins-list/use-actions.tsx b/client/my-sites/plugins/plugins-list/use-actions.tsx
index ce82e1a8f00f2..481ae409fa19a 100644
--- a/client/my-sites/plugins/plugins-list/use-actions.tsx
+++ b/client/my-sites/plugins/plugins-list/use-actions.tsx
@@ -1,6 +1,7 @@
 import { Icon, link, linkOff, trash } from '@wordpress/icons';
 import { translate } from 'i18n-calypso';
 import { navigate } from 'calypso/lib/navigate';
+import { PLUGINS_STATUS } from 'calypso/state/plugins/installed/status/constants';
 import { Plugin } from 'calypso/state/plugins/installed/types';
 import { PluginActions } from '../hooks/types';
 
@@ -27,7 +28,9 @@ export function useActions(
 			},
 			label: translate( 'Activate' ),
 			isExternalLink: true,
-			isEnabled: true,
+			isEligible( plugin: Plugin ) {
+				return plugin.status?.includes( PLUGINS_STATUS.INACTIVE ) ?? true;
+			},
 			supportsBulk: true,
 			icon: <Icon icon={ link } />,
 		},
@@ -39,7 +42,9 @@ export function useActions(
 			},
 			label: translate( 'Deactivate' ),
 			isExternalLink: true,
-			isEnabled: true,
+			isEligible( plugin: Plugin ) {
+				return plugin.status?.includes( PLUGINS_STATUS.ACTIVE ) ?? true;
+			},
 			supportsBulk: true,
 			icon: <Icon icon={ linkOff } />,
 		},
@@ -51,7 +56,9 @@ export function useActions(
 			},
 			label: translate( 'Enable auto-updates' ),
 			isExternalLink: true,
-			isEnabled: true,
+			isEligible( plugin: Plugin ) {
+				return plugin.status?.includes( PLUGINS_STATUS.AUTOUPDATE_DISABLED ) ?? true;
+			},
 			supportsBulk: true,
 		},
 		{
@@ -62,7 +69,9 @@ export function useActions(
 			},
 			label: translate( 'Disable auto-updates' ),
 			isExternalLink: true,
-			isEnabled: true,
+			isEligible( plugin: Plugin ) {
+				return plugin.status?.includes( PLUGINS_STATUS.AUTOUPDATE_ENABLED ) ?? true;
+			},
 			supportsBulk: true,
 		},
 		{
diff --git a/client/state/plugins/installed/selectors.js b/client/state/plugins/installed/selectors.js
index a4dc4bc5b64da..addb4fb2c07d5 100644
--- a/client/state/plugins/installed/selectors.js
+++ b/client/state/plugins/installed/selectors.js
@@ -40,6 +40,20 @@ const _filters = {
 			} ) || plugin.statusRecentlyChanged
 		);
 	},
+	autoupdates: function ( plugin ) {
+		return (
+			some( plugin.sites, function ( site ) {
+				return site.autoupdate;
+			} ) || plugin.statusRecentlyChanged
+		);
+	},
+	autoupdates_disabled: function ( plugin ) {
+		return (
+			some( plugin.sites, function ( site ) {
+				return ! site.autoupdate;
+			} ) || plugin.statusRecentlyChanged
+		);
+	},
 	isEqual: function ( pluginSlug, plugin ) {
 		return plugin.slug === pluginSlug;
 	},
@@ -125,6 +139,8 @@ export const getPluginsWithUpdateStatuses = createSelector(
 		const active = filter( allPlugins, _filters.active );
 		const inactive = filter( allPlugins, _filters.inactive );
 		const withUpdate = filter( allPlugins, _filters.updates );
+		const withAutoUpdate = filter( allPlugins, _filters.autoupdates );
+		const withAutoUpdateDisabled = filter( allPlugins, _filters.autoupdates_disabled );
 
 		return allPlugins.reduce( ( memo, plugin ) => {
 			const status = [];
@@ -153,6 +169,15 @@ export const getPluginsWithUpdateStatuses = createSelector(
 			if ( find( active, { slug: plugin.slug } ) ) {
 				status.push( PLUGINS_STATUS.ACTIVE );
 			}
+
+			if ( find( withAutoUpdate, { slug: plugin.slug } ) ) {
+				status.push( PLUGINS_STATUS.AUTOUPDATE_ENABLED );
+			}
+
+			if ( find( withAutoUpdateDisabled, { slug: plugin.slug } ) ) {
+				status.push( PLUGINS_STATUS.AUTOUPDATE_DISABLED );
+			}
+
 			return [ ...memo, { ...plugin, status } ];
 		}, [] );
 	},
diff --git a/client/state/plugins/installed/status/constants.ts b/client/state/plugins/installed/status/constants.ts
index 200fe138d81b2..8282cd4a6c0ba 100644
--- a/client/state/plugins/installed/status/constants.ts
+++ b/client/state/plugins/installed/status/constants.ts
@@ -11,4 +11,6 @@ export const PLUGINS_STATUS = {
 	ACTIVE: 1,
 	INACTIVE: 2,
 	UPDATE: 3,
+	AUTOUPDATE_ENABLED: 4,
+	AUTOUPDATE_DISABLED: 5,
 };
diff --git a/client/state/plugins/installed/test/selectors.js b/client/state/plugins/installed/test/selectors.js
index c82eb435378ff..fb7a8b46e3075 100644
--- a/client/state/plugins/installed/test/selectors.js
+++ b/client/state/plugins/installed/test/selectors.js
@@ -496,7 +496,11 @@ describe( 'Installed plugin selectors', () => {
 								version: '1.0',
 							},
 						},
-						status: [ PLUGINS_STATUS.UPDATE, PLUGINS_STATUS.ACTIVE ],
+						status: [
+							PLUGINS_STATUS.UPDATE,
+							PLUGINS_STATUS.ACTIVE,
+							PLUGINS_STATUS.AUTOUPDATE_ENABLED,
+						],
 						allStatuses: [
 							{
 								action: 'DEACTIVATE_PLUGIN',
@@ -516,14 +520,14 @@ describe( 'Installed plugin selectors', () => {
 						id: 'hello-dolly/hello-dolly',
 						slug: 'hello-dolly/hello-dolly',
 						sites: { 'site.one': { active: true } },
-						status: [ PLUGINS_STATUS.ACTIVE ],
+						status: [ PLUGINS_STATUS.ACTIVE, PLUGINS_STATUS.AUTOUPDATE_DISABLED ],
 						allStatuses: [],
 					},
 					{
 						id: 'vaultpress/vaultpress',
 						slug: 'vaultpress/vaultpress',
 						sites: { 'site.one': { active: false } },
-						status: [ PLUGINS_STATUS.INACTIVE ],
+						status: [ PLUGINS_STATUS.INACTIVE, PLUGINS_STATUS.AUTOUPDATE_DISABLED ],
 						allStatuses: [],
 					},
 				] )