diff --git a/packages/api/package.json b/packages/api/package.json
index dc4854448c45..4cddda4b4033 100644
--- a/packages/api/package.json
+++ b/packages/api/package.json
@@ -69,7 +69,7 @@
     "check-readme": "typescript-docs-verifier"
   },
   "dependencies": {
-    "@chainsafe/persistent-merkle-tree": "^0.5.0",
+    "@chainsafe/persistent-merkle-tree": "^0.6.1",
     "@chainsafe/ssz": "^0.13.0",
     "@lodestar/config": "^1.11.3",
     "@lodestar/params": "^1.11.3",
diff --git a/packages/beacon-node/package.json b/packages/beacon-node/package.json
index 7af605f6f603..71dc7ec65dea 100644
--- a/packages/beacon-node/package.json
+++ b/packages/beacon-node/package.json
@@ -102,7 +102,7 @@
     "@chainsafe/discv5": "^5.1.0",
     "@chainsafe/libp2p-gossipsub": "^10.1.0",
     "@chainsafe/libp2p-noise": "^13.0.0",
-    "@chainsafe/persistent-merkle-tree": "^0.5.0",
+    "@chainsafe/persistent-merkle-tree": "^0.6.1",
     "@chainsafe/prometheus-gc-stats": "^1.0.0",
     "@chainsafe/ssz": "^0.13.0",
     "@chainsafe/threads": "^1.11.1",
diff --git a/packages/cli/package.json b/packages/cli/package.json
index ab9e09e39a3c..9cec49cbf419 100644
--- a/packages/cli/package.json
+++ b/packages/cli/package.json
@@ -61,6 +61,7 @@
     "@chainsafe/discv5": "^5.1.0",
     "@chainsafe/ssz": "^0.13.0",
     "@chainsafe/threads": "^1.11.1",
+    "@chainsafe/persistent-merkle-tree": "^0.6.1",
     "@libp2p/crypto": "^2.0.2",
     "@libp2p/peer-id": "^3.0.1",
     "@libp2p/peer-id-factory": "^3.0.2",
diff --git a/packages/cli/src/applyPreset.ts b/packages/cli/src/applyPreset.ts
index f0f784f8ae61..760c18dbbcd7 100644
--- a/packages/cli/src/applyPreset.ts
+++ b/packages/cli/src/applyPreset.ts
@@ -1,4 +1,13 @@
 // MUST import this file first before anything and not import any Lodestar code.
+
+// eslint-disable-next-line no-restricted-imports, import/no-extraneous-dependencies
+import {hasher} from "@chainsafe/persistent-merkle-tree/lib/hasher/as-sha256.js";
+// eslint-disable-next-line no-restricted-imports, import/no-extraneous-dependencies
+import {setHasher} from "@chainsafe/persistent-merkle-tree/lib/hasher/index.js";
+
+// without setting this first, persistent-merkle-tree will use noble instead
+setHasher(hasher);
+
 //
 // ## Rationale
 //
diff --git a/packages/cli/src/index.ts b/packages/cli/src/index.ts
index add49804c9be..5cdccbacfeec 100644
--- a/packages/cli/src/index.ts
+++ b/packages/cli/src/index.ts
@@ -1,6 +1,6 @@
 #!/usr/bin/env node
 
-// MUST import first to apply preset from args
+// MUST import first to apply preset from args and set ssz hasher
 import "./applyPreset.js";
 import {YargsError} from "./util/index.js";
 import {getLodestarCli, yarg} from "./cli.js";
diff --git a/packages/light-client/package.json b/packages/light-client/package.json
index 3f10ecd67aa4..8a33f2fa862c 100644
--- a/packages/light-client/package.json
+++ b/packages/light-client/package.json
@@ -65,7 +65,7 @@
   },
   "dependencies": {
     "@chainsafe/bls": "7.1.1",
-    "@chainsafe/persistent-merkle-tree": "^0.5.0",
+    "@chainsafe/persistent-merkle-tree": "^0.6.1",
     "@chainsafe/ssz": "^0.13.0",
     "@lodestar/api": "^1.11.3",
     "@lodestar/config": "^1.11.3",
diff --git a/packages/light-client/src/utils/verifyMerkleBranch.ts b/packages/light-client/src/utils/verifyMerkleBranch.ts
index 7cdf673aaf87..87b1d660eb32 100644
--- a/packages/light-client/src/utils/verifyMerkleBranch.ts
+++ b/packages/light-client/src/utils/verifyMerkleBranch.ts
@@ -1,5 +1,5 @@
 import {byteArrayEquals} from "@chainsafe/ssz";
-import {hash} from "@chainsafe/persistent-merkle-tree";
+import {hasher} from "@chainsafe/persistent-merkle-tree";
 
 export const SYNC_COMMITTEES_DEPTH = 4;
 export const SYNC_COMMITTEES_INDEX = 11;
@@ -20,9 +20,9 @@ export function isValidMerkleBranch(
   let value = leaf;
   for (let i = 0; i < depth; i++) {
     if (Math.floor(index / 2 ** i) % 2) {
-      value = hash(proof[i], value);
+      value = hasher.digest64(proof[i], value);
     } else {
-      value = hash(value, proof[i]);
+      value = hasher.digest64(value, proof[i]);
     }
   }
   return byteArrayEquals(value, root);
diff --git a/packages/light-client/test/utils/utils.ts b/packages/light-client/test/utils/utils.ts
index c5f5b78afe42..df9bd4170dcc 100644
--- a/packages/light-client/test/utils/utils.ts
+++ b/packages/light-client/test/utils/utils.ts
@@ -1,6 +1,6 @@
 import bls from "@chainsafe/bls/switchable";
 import {PointFormat, PublicKey, SecretKey} from "@chainsafe/bls/types";
-import {hash, Tree} from "@chainsafe/persistent-merkle-tree";
+import {hasher, Tree} from "@chainsafe/persistent-merkle-tree";
 import {BitArray, fromHexString} from "@chainsafe/ssz";
 import {BeaconConfig} from "@lodestar/config";
 import {
@@ -235,9 +235,9 @@ export function computeMerkleBranch(
   for (let i = 0; i < depth; i++) {
     proof[i] = Buffer.alloc(32, i);
     if (Math.floor(index / 2 ** i) % 2) {
-      value = hash(proof[i], value);
+      value = hasher.digest64(proof[i], value);
     } else {
-      value = hash(value, proof[i]);
+      value = hasher.digest64(value, proof[i]);
     }
   }
   return {root: value, proof};
diff --git a/packages/prover/src/cli/applyPreset.ts b/packages/prover/src/cli/applyPreset.ts
index a6a3568c5f91..158e05243ec7 100644
--- a/packages/prover/src/cli/applyPreset.ts
+++ b/packages/prover/src/cli/applyPreset.ts
@@ -1,4 +1,13 @@
 // MUST import this file first before anything and not import any Lodestar code.
+
+// eslint-disable-next-line no-restricted-imports, import/no-extraneous-dependencies
+import {hasher} from "@chainsafe/persistent-merkle-tree/lib/hasher/as-sha256.js";
+// eslint-disable-next-line no-restricted-imports, import/no-extraneous-dependencies
+import {setHasher} from "@chainsafe/persistent-merkle-tree/lib/hasher/index.js";
+
+// without setting this first, persistent-merkle-tree will use noble instead
+setHasher(hasher);
+
 //
 // ## Rationale
 //
diff --git a/packages/prover/src/cli/index.ts b/packages/prover/src/cli/index.ts
index 53a32a02eb87..845831b32cb0 100644
--- a/packages/prover/src/cli/index.ts
+++ b/packages/prover/src/cli/index.ts
@@ -1,6 +1,6 @@
 #!/usr/bin/env node
 
-// MUST import first to apply preset from args
+// MUST import first to apply preset from args and set ssz hasher
 import "./applyPreset.js";
 import {YargsError} from "../utils/errors.js";
 import {getLodestarProverCli, yarg} from "./cli.js";
diff --git a/packages/state-transition/package.json b/packages/state-transition/package.json
index 269e8e129f48..ec2b7dfe0b31 100644
--- a/packages/state-transition/package.json
+++ b/packages/state-transition/package.json
@@ -59,7 +59,7 @@
   "dependencies": {
     "@chainsafe/as-sha256": "^0.3.1",
     "@chainsafe/bls": "7.1.1",
-    "@chainsafe/persistent-merkle-tree": "^0.5.0",
+    "@chainsafe/persistent-merkle-tree": "^0.6.1",
     "@chainsafe/persistent-ts": "^0.19.1",
     "@chainsafe/ssz": "^0.13.0",
     "@lodestar/config": "^1.11.3",
diff --git a/yarn.lock b/yarn.lock
index 03c4f41a0ba9..845284ca8cc4 100644
--- a/yarn.lock
+++ b/yarn.lock
@@ -611,13 +611,6 @@
   dependencies:
     "@chainsafe/is-ip" "^2.0.1"
 
-"@chainsafe/persistent-merkle-tree@^0.5.0":
-  version "0.5.0"
-  resolved "https://registry.yarnpkg.com/@chainsafe/persistent-merkle-tree/-/persistent-merkle-tree-0.5.0.tgz#2b4a62c9489a5739dedd197250d8d2f5427e9f63"
-  integrity sha512-l0V1b5clxA3iwQLXP40zYjyZYospQLZXzBVIhhr9kDg/1qHZfzzHw0jj4VPBijfYCArZDlPkRi1wZaV2POKeuw==
-  dependencies:
-    "@chainsafe/as-sha256" "^0.3.1"
-
 "@chainsafe/persistent-merkle-tree@^0.6.1":
   version "0.6.1"
   resolved "https://registry.yarnpkg.com/@chainsafe/persistent-merkle-tree/-/persistent-merkle-tree-0.6.1.tgz#37bde25cf6cbe1660ad84311aa73157dc86ec7f2"