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utd.html
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<!DOCTYPE html>
<html class="no-js" lang="en" dir="ltr">
<head>
<meta charset="utf-8">
<meta content="width=device-width,initial-scale=1" name="viewport">
<link rel="schema.dcterms" href="http://purl.org/dc/terms/">
<meta name="description" content="Information about any adverse events following immunization (AEFI) that individuals have reported after receiving a COVID-19 vaccine in Canada. These adverse events are not necessarily related to the vaccine.">
<meta name="keywords" content="coronavirus, covid-19, pandemic, Canada, vaccines covid, vaccines canada, vaccines covid, coronavirus vaccines, safety, side effects, adverse reaction, AEFI">
<meta name="author" content="Public Health Agency of Canada">
<meta name="dcterms.title" content="COVID-19 vaccine safety: Understanding the data on side effects following immunization">
<meta name="dcterms.description" content="Information about any adverse events following immunization (AEFI) that individuals have reported after receiving a COVID-19 vaccine in Canada. These adverse events are not necessarily related to the vaccine.">
<meta name="dcterms.creator" content="Public Health Agency of Canada">
<meta name="dcterms.language" title="ISO639-2/T" content="eng">
<meta name="dcterms.subject" title="gccore" content="HE Health and Safety">
<meta name="dcterms.issued" title="W3CDTF" content="2021-01-08">
<meta name="dcterms.modified" title="W3CDTF" content="2021-01-29">
<meta name="dcterms.spatial" content="Canada">
<meta name="dcterms.type" content="datasets;statistics;education and awareness">
<meta name="dcterms.source" content="aem">
<meta name="dcterms.identifier" content="Public_Health_Agency_of_Canada">
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<title> COVID-19 vaccine safety: Understanding the data on side effects following immunization - Canada.ca</title>
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<h1>Reported side effects following COVID-19 vaccination in Canada</h1>
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<a class="btn btn-default" role="button" href="/covid-19/vaccine-safety/summary.html">Summary</a>
<a class="btn btn-default" role="button" href="/covid-19/vaccine-safety/">Detailed Report</a>
<a class="btn btn-primary active" role="button" href="#">Understanding the data</a>
<a class="btn btn-default" role="button" href="/covid-19/vaccine-safety/archive/">Archived reports</a>
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<p>This page will be updated next on January 20, 2023 at noon EST.</p>
<p>This page was last updated on December 22, 2022 with data up to and including December 9, 2022.</p>
<h2>On this page</h2>
<ul>
<li><a href="#a1" class="anchor">Definitions</a></li>
<li><a href="#a2" class="anchor">Background information on the regulatory processes</a></li>
<li><a href="#a3" class="anchor">Monitoring the safety of marketed vaccines in Canada </a></li>
<li><a href="#a4" class="anchor">Data notes</a></li>
</ul>
<h3 id="a1">Definitions</h3>
<details>
<summary>Adverse Event Following Immunization (AEFI)</summary>
<p>An AEFI is any untoward medical occurrence that follows immunization. It isn’t necessarily causally related to the usage of the vaccine. The adverse event may be any:</p>
<ul>
<li>unfavourable or unintended sign (for example, skin rash)</li>
<li>abnormal laboratory finding</li>
<li>symptom or </li>
<li>disease</li>
</ul>
<p style="font-size:15px;">For more information, please refer to the <a href="https://www.who.int/vaccine_safety/initiative/tools/CIOMS_report_WG_vaccine.pdf">Council for International Organizations of Medical Sciences (CIOMS) and World Health Organization. Report of CIOMS/WHO Working group on Vaccine Pharmacovigilance.</a></p>
</details>
<details>
<summary>Adverse event report</summary>
<p>One adverse event report, which represents 1 person, may report on more than 1 symptom (that is a adverse event following immunization, or AEFI). </p>
</details>
<details>
<summary>Serious adverse event</summary>
<p>An event is considered serious if it:</p>
<ul>
<li>results in death</li>
<li>is life-threatening (an event/reaction in which the patient was at real, rather than hypothetical, risk of death at the time of the event/reaction)</li>
<li>requires in-patient hospitalization or prolongation of existing hospitalization</li>
<li>results in persistent or significant disability/incapacity, or</li>
<li>results in a congenital anomaly/birth defect</li>
</ul>
</details>
<details>
<summary>Medically important event</summary>
<p>An event that may not be immediately life-threatening but requires intervention to prevent 1 of the outcomes listed above and may also be considered as serious. This is based on the International Council on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use. See:</p>
<p style="font-size:15px;"><a href="https://www.ich.org/page/efficacy-guidelines">International Council on Harmonisation.</a></p>
</details>
<details>
<summary>Adverse Events of Special Interest (AESI)</summary>
<p>This is a pre-specified medically significant event that has the potential to be causally associated with a vaccine product. It must be carefully monitored and confirmed by further special studies.</p>
<span style="font-size:15px;">For more information, please refer to the <a href="https://www.who.int/vaccine_safety/committee/Module_AESI.pdf?ua=1">World Health Organization. COVID-19 Vaccines: Safety Surveillance Manual.</a></span>
</details>
<details>
<summary id="safetySummary">Safety signal</summary>
<p>Information indicating a new and potentially causal association between a vaccine and an event that could affect health. The event is either unknown or incompletely documented. It could also indicate a new aspect of a known association. The primary purpose of vaccine post-market surveillance is to detect safety concerns, such as:</p>
<ul>
<li>a possible increase in the severity or frequency of expected adverse events following immunization, or</li>
<li>one or more unexpected events (such as an event that is not consistent with Canadian product information or labelling).</li>
</ul>
<span style="font-size:15px;">For more information, please refer to World Health Organization. COVID-19 Vaccines: <a href="https://www.who.int/vaccine_safety/committee/Module_AESI.pdf?ua=1">Safety Surveillance Manual</a>. </span>
</details>
<details>
<summary>Brighton Collaboration diagnostic level of certainty</summary>
<p>Brighton Collaboration case definitions are standardized for adverse events following immunization (AEFI). They allow AEFIs to be compared across different data sources. Clinical information on the AEFI is reviewed and categorized into 1 of 5 categories. AEFIs that meet levels 1-3 have enough information to confirm that they are a case. AEFIs that meet level 4 lack sufficient information to meet the case definition. AEFIs categorized as level 5 do not meet the case definition.</p>
</details>
<h3 id="a2">Background information on the regulatory processes</h3>
<p>Canada’s independent drug authorization process is known around the world for its high standards and rigorous review process. Decisions are based only on scientific and medical evidence showing that the vaccines are safe and effective. The benefits must also outweigh any risks. All vaccines approved in Canada are proven safe, effective and of high quality.</p>
<p>The work to make sure a vaccine is safe starts before the regulatory process even begins. Exploratory, preclinical studies and clinical trials are conducted to assess the vaccine’s safety and efficacy. Evidence from these activities is submitted to Health Canada for regulatory review. Health Canada’s scientific and medical reviewers then conduct a thorough and independent review of all vaccine data. Only then is a vaccine authorized for use in Canada. </p>
<p>Learn more about <a href="https://www.canada.ca/en/health-canada/services/drugs-health-products/covid19-industry/drugs-vaccines-treatments/vaccines/development-approval-infographic.html">how vaccines are approved in Canada</a>.</p>
<p>Once a vaccine has been approved, it is distributed and administered, and Health Canada provides regulatory oversight for safety, quality and effectiveness. </p>
<p>For more information, please refer to <a href="https://www.canada.ca/en/health-canada/services/drugs-health-products/covid19-industry/drugs-vaccines-treatments/authorization.html">how Health Canada regulates COVID-19 vaccines in Canada.</a></p>
<p>To learn more about each COVID-19 vaccine, please refer to the <a href="https://www.canada.ca/en/health-canada/services/drugs-health-products/covid19-industry/drugs-vaccines-treatments/vaccines.html">approved COVID-19 vaccines page</a>. Health Canada regularly updates a <a href="https://covid-vaccine.canada.ca/">post-authorization activity table</a> (PAAT) for each COVID-19 vaccine and treatment. The PAAT summarizes activities since authorization, including updates to the product monographs.</p>
<h3 id="a3">Monitoring the safety of marketed vaccines in Canada</h3>
<p>Health Canada and PHAC, along with public health authorities in the provinces and territories, actively monitor the safety of COVID-19 vaccines authorized in Canada. This is to ensure that these vaccines are safe, and that their benefits continue to outweigh the risks of the disease. </p>
<p>If you experience any adverse events (side effects) after being vaccinated in Canada, please report them to a healthcare provider. Vaccine monitoring begins with the collection of information from the adverse event reporting forms that are submitted. </p>
<p>For more information, refer to the following:</p>
<ul>
<li>
<a href="https://www.canada.ca/en/public-health/services/publications/healthy-living/canadian-immunization-guide-part-2-vaccine-safety/page-2-vaccine-safety.html">Safety monitoring of COVID-19 Vaccines</a>
<ul>
<li><a href="https://www.canada.ca/en/health-canada/services/drugs-health-products/medeffect-canada/canada-vigilance-program.html">Canada Vigilance Program</a></li>
<li><a href="https://www.canada.ca/en/public-health/services/immunization/canadian-adverse-events-following-immunization-surveillance-system-caefiss.html">Canadian Adverse Events Following Immunization Surveillance System (CAEFISS.)</a></li>
</ul>
</li>
<li>
<a href="https://www.canada.ca/en/public-health/services/immunization/reporting-adverse-events-following-immunization/form.html">Reporting adverse events</a>
</li>
</ul>
<h2 id="a4">Data notes</h2>
<p>The data presented in this report are estimates and may not accurately represent national COVID-19 vaccine adverse events following immunization for the following reasons:</p>
<ol>
<li>There may be delays in receiving reporting forms and processing reporting forms which may contribute to variations in the amount of reports presented between postings. These delays may be due to jurisdictions investigating and reviewing each adverse event before submitting the information to PHAC. There are also limitations to reporting practices such as underreporting, missing information, and differing adverse event reporting practices across jurisdictions in Canada. </li>
<li>Each posting, we update the historical data to include any delayed reporting forms from earlier weeks.</li>
<li>Information is collected on individuals for whom an report was submitted, not on the total number of individuals who experience an adverse event as not every adverse event is reported. </li>
<li>New information in this report may not be comprehensive but rather represents preliminary results of data received since the last posting.</li>
<li>Reporting jurisdictions may refer to gender as opposed to sex.</li>
<li>Information on COVID-19 vaccine doses administered are obtained from provincial and territorial partners or their websites. More details on the number of COVID-19 vaccine doses administered, please consult the <a href="https://health-infobase.canada.ca/covid-19/vaccination-coverage/technical-notes.html">COVID-19 vaccination coverage webpage</a>.</li>
<li>The data presented in this report represent combined numbers from both CAEFISS and the Canada Vigilance program. Canada Vigilance receives reports directly from vaccine manufacturers, healthcare professionals and consumers. CAEFISS receives reports from regional public health authorities. Although data from these 2 surveillance systems are carefully merged together, the individual programs are subject to different reporting requirements and definitions. It is also possible that the report contains duplicate reports.</li>
<li>Adverse events of special interest are assessed according to the <a href="https://brightoncollaboration.us/category/pubs-tools/case-definitions/">Brighton Collaboration level of diagnostic certainty</a> (if available).</li>
<li>Please note, the adverse event and AESI numbers in Figure 4 and Table 1 may be adjusted following medical case review.</li>
<li>For adverse events with low counts (less than 10) or incomplete data on doses administered, rates will not be provided.</li>
<li>References to age or age group in this report reflects the person's age at the time of vaccination.</li>
<li>Deaths are assessed according to the <a href="https://www.who.int/publications-detail-redirect/9789241516990">causality assessment of an adverse event following immunization (AEFI), user manual</a> for the revised WHO classification</li>
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