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pko-base.owl
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<?xml version="1.0"?>
<rdf:RDF xmlns="http://si.eu-parc.eu//pko/pko-base.owl#"
xml:base="http://si.eu-parc.eu//pko/pko-base.owl"
xmlns:dce="http://purl.org/dc/elements/1.1/"
xmlns:obo="http://purl.obolibrary.org/obo/"
xmlns:owl="http://www.w3.org/2002/07/owl#"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:xml="http://www.w3.org/XML/1998/namespace"
xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
xmlns:dcterms="http://purl.org/dc/terms/">
<owl:Ontology rdf:about="http://si.eu-parc.eu//pko/pko-base.owl">
<owl:versionIRI rdf:resource="http://si.eu-parc.eu//pko/releases/2023-11-13/pko-base.owl"/>
<dce:type rdf:resource="http://purl.obolibrary.org/obo/IAO_8000001"/>
<dcterms:description>None</dcterms:description>
<dcterms:license rdf:resource="https://creativecommons.org/licenses/unspecified"/>
<dcterms:title>pharmokinetic-ontology</dcterms:title>
<owl:versionInfo>2023-11-13</owl:versionInfo>
</owl:Ontology>
<!--
///////////////////////////////////////////////////////////////////////////////////////
//
// Annotation properties
//
///////////////////////////////////////////////////////////////////////////////////////
-->
<!-- http://purl.obolibrary.org/obo/IAO_0000115 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115"/>
<!-- http://purl.obolibrary.org/obo/IAO_0000117 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000117"/>
<!-- http://purl.obolibrary.org/obo/IAO_0000119 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000119"/>
<!-- http://purl.obolibrary.org/obo/IAO_0000605 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000605"/>
<!-- http://purl.org/dc/elements/1.1/type -->
<owl:AnnotationProperty rdf:about="http://purl.org/dc/elements/1.1/type"/>
<!-- http://purl.org/dc/terms/description -->
<owl:AnnotationProperty rdf:about="http://purl.org/dc/terms/description">
<rdfs:label>description</rdfs:label>
</owl:AnnotationProperty>
<!-- http://purl.org/dc/terms/license -->
<owl:AnnotationProperty rdf:about="http://purl.org/dc/terms/license">
<rdfs:label>license</rdfs:label>
</owl:AnnotationProperty>
<!-- http://purl.org/dc/terms/title -->
<owl:AnnotationProperty rdf:about="http://purl.org/dc/terms/title">
<rdfs:label>title</rdfs:label>
</owl:AnnotationProperty>
<!--
///////////////////////////////////////////////////////////////////////////////////////
//
// Classes
//
///////////////////////////////////////////////////////////////////////////////////////
-->
<!-- http://si.eu-parc.eu/PKO_0000000 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000000">
<rdfs:label xml:lang="en">root node</rdfs:label>
</owl:Class>
<!-- http://si.eu-parc.eu/PKO_0000004 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000004">
<obo:IAO_0000115>Physiologically based pharmacokinetic (PBPK) modeling is a mathematical modeling technique that predicts the absorption, distribution, metabolism, and excretion (ADME) of synthetic or natural chemical substances in humans and other animal species</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<obo:IAO_0000605>PBPK</obo:IAO_0000605>
<rdfs:label>Physiologically Based Pharmacokinetic Modeling</rdfs:label>
</owl:Class>
<owl:Axiom>
<owl:annotatedSource rdf:resource="http://si.eu-parc.eu/PKO_0000004"/>
<owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
<owl:annotatedTarget>Physiologically based pharmacokinetic (PBPK) modeling is a mathematical modeling technique that predicts the absorption, distribution, metabolism, and excretion (ADME) of synthetic or natural chemical substances in humans and other animal species</owl:annotatedTarget>
<obo:IAO_0000119>10.1038/psp.2013.41</obo:IAO_0000119>
</owl:Axiom>
<!-- http://si.eu-parc.eu/PKO_0000005 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000005">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000004"/>
<obo:IAO_0000115>A whole-body PBPK model contains an explicit representation of the organs that are most relevant to the absorption, distribution, excretion, and metabolization of the drug/chemicals due to their physiological/pharmacological function or their volume</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<obo:IAO_0000605>All organs PBPK</obo:IAO_0000605>
<rdfs:label>Whole body PBPK Model</rdfs:label>
</owl:Class>
<owl:Axiom>
<owl:annotatedSource rdf:resource="http://si.eu-parc.eu/PKO_0000005"/>
<owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
<owl:annotatedTarget>A whole-body PBPK model contains an explicit representation of the organs that are most relevant to the absorption, distribution, excretion, and metabolization of the drug/chemicals due to their physiological/pharmacological function or their volume</owl:annotatedTarget>
<obo:IAO_0000119>10.1002/psp4.12134</obo:IAO_0000119>
</owl:Axiom>
<!-- http://si.eu-parc.eu/PKO_0000006 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000006">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000004"/>
<obo:IAO_0000115>Perfusion-limited models are a type of physiologically based pharmacokinetic (PBPK) model that assumes that the concentration of a substance in tissues reaches equilibrium with the substance in the circulation rapidly. In perfusion-limited models, the rate of drug uptake by tissues is limited by blood flow, and the rate of drug elimination is limited by the rate of diffusion from the tissue to the blood</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>Perfusion Limited Model</rdfs:label>
</owl:Class>
<owl:Axiom>
<owl:annotatedSource rdf:resource="http://si.eu-parc.eu/PKO_0000006"/>
<owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
<owl:annotatedTarget>Perfusion-limited models are a type of physiologically based pharmacokinetic (PBPK) model that assumes that the concentration of a substance in tissues reaches equilibrium with the substance in the circulation rapidly. In perfusion-limited models, the rate of drug uptake by tissues is limited by blood flow, and the rate of drug elimination is limited by the rate of diffusion from the tissue to the blood</owl:annotatedTarget>
<obo:IAO_0000119>https://doi.org/10.3390/nano10071267</obo:IAO_0000119>
</owl:Axiom>
<!-- http://si.eu-parc.eu/PKO_0000007 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000007">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000006"/>
<obo:IAO_0000115>Physiological parameters in PBPK modeling provide the structural framework of the model and are used to simulate the absorption, distribution, metabolism, and excretion (ADME) of a substance throughout the body. These parameters include body weight, height, organ volume, cardiac output, organ blood flow, and tissue composition.</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>Physiological Parameters</rdfs:label>
</owl:Class>
<owl:Axiom>
<owl:annotatedSource rdf:resource="http://si.eu-parc.eu/PKO_0000007"/>
<owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
<owl:annotatedTarget>Physiological parameters in PBPK modeling provide the structural framework of the model and are used to simulate the absorption, distribution, metabolism, and excretion (ADME) of a substance throughout the body. These parameters include body weight, height, organ volume, cardiac output, organ blood flow, and tissue composition.</owl:annotatedTarget>
<obo:IAO_0000119>10.3390/ijerph20043473</obo:IAO_0000119>
</owl:Axiom>
<!-- http://si.eu-parc.eu/PKO_0000008 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000008">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000007"/>
<obo:IAO_0000115>An individual's weight in kilograms divided by the square of the height in meters.</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<obo:IAO_0000605>BMI</obo:IAO_0000605>
<rdfs:label> Body Mass Index </rdfs:label>
</owl:Class>
<owl:Axiom>
<owl:annotatedSource rdf:resource="http://si.eu-parc.eu/PKO_0000008"/>
<owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
<owl:annotatedTarget>An individual's weight in kilograms divided by the square of the height in meters.</owl:annotatedTarget>
<obo:IAO_0000119>http://purl.obolibrary.org/obo/NCIT_C16358</obo:IAO_0000119>
</owl:Axiom>
<!-- http://si.eu-parc.eu/PKO_0000009 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000009">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000007"/>
<obo:IAO_0000115> Mass or quantity of heaviness of an individual. </obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<obo:IAO_0000605>BW</obo:IAO_0000605>
<rdfs:label>BW (Kg)</rdfs:label>
</owl:Class>
<owl:Axiom>
<owl:annotatedSource rdf:resource="http://si.eu-parc.eu/PKO_0000009"/>
<owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
<owl:annotatedTarget> Mass or quantity of heaviness of an individual. </owl:annotatedTarget>
<obo:IAO_0000119>http://purl.bioontology.org/ontology/MESH/D001835</obo:IAO_0000119>
</owl:Axiom>
<!-- http://si.eu-parc.eu/PKO_0000010 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000010">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000007"/>
<obo:IAO_0000115>Height is a term used to describe the distance from the bottom to the top of someone or something standing upright</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<obo:IAO_0000605>HT</obo:IAO_0000605>
<rdfs:label>HT</rdfs:label>
</owl:Class>
<owl:Axiom>
<owl:annotatedSource rdf:resource="http://si.eu-parc.eu/PKO_0000010"/>
<owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
<owl:annotatedTarget>Height is a term used to describe the distance from the bottom to the top of someone or something standing upright</owl:annotatedTarget>
<obo:IAO_0000119>Height Definition & Meaning - Merriam-Webster</obo:IAO_0000119>
</owl:Axiom>
<!-- http://si.eu-parc.eu/PKO_0000011 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000011">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000007"/>
<obo:IAO_0000115> A measure of total area i.e., surface of object occupies. or
The two dimensional measure of the outer layer of the body.</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<obo:IAO_0000605>BSA/SA</obo:IAO_0000605>
<rdfs:label>Surface area</rdfs:label>
</owl:Class>
<owl:Axiom>
<owl:annotatedSource rdf:resource="http://si.eu-parc.eu/PKO_0000011"/>
<owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
<owl:annotatedTarget> A measure of total area i.e., surface of object occupies. or
The two dimensional measure of the outer layer of the body.</owl:annotatedTarget>
<obo:IAO_0000119>http://semanticscience.org/resource/SIO_001407
http://purl.bioontology.org/ontology/MESH/D001830</obo:IAO_0000119>
</owl:Axiom>
<!-- http://si.eu-parc.eu/PKO_0000012 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000012">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000007"/>
<obo:IAO_0000115>A geographic ancestral origin category assigned to a population group .</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>Race</rdfs:label>
</owl:Class>
<owl:Axiom>
<owl:annotatedSource rdf:resource="http://si.eu-parc.eu/PKO_0000012"/>
<owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
<owl:annotatedTarget>A geographic ancestral origin category assigned to a population group .</owl:annotatedTarget>
<obo:IAO_0000119>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17049</obo:IAO_0000119>
</owl:Axiom>
<!-- http://si.eu-parc.eu/PKO_0000013 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000013">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000007"/>
<obo:IAO_0000115>Blood flow in PBPK modeling refers to the rate of blood flow to a particular organ or tissue, which is used to calculate the rate of drug delivery to that organ or tissue/chemical</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<obo:IAO_0000605>Q</obo:IAO_0000605>
<rdfs:label>Blood flow</rdfs:label>
</owl:Class>
<owl:Axiom>
<owl:annotatedSource rdf:resource="http://si.eu-parc.eu/PKO_0000013"/>
<owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
<owl:annotatedTarget>Blood flow in PBPK modeling refers to the rate of blood flow to a particular organ or tissue, which is used to calculate the rate of drug delivery to that organ or tissue/chemical</owl:annotatedTarget>
<obo:IAO_0000119>10.1002/psp4.12134</obo:IAO_0000119>
</owl:Axiom>
<!-- http://si.eu-parc.eu/PKO_0000014 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000014">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000013"/>
<obo:IAO_0000115>Cardiac output in PBPK modeling refers to the volume of blood pumped by the heart per unit of time, which is used to calculate the rate of blood flow to different organs and tissues in the body</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<obo:IAO_0000605>CO</obo:IAO_0000605>
<rdfs:label>Cardiac Output</rdfs:label>
</owl:Class>
<owl:Axiom>
<owl:annotatedSource rdf:resource="http://si.eu-parc.eu/PKO_0000014"/>
<owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
<owl:annotatedTarget>Cardiac output in PBPK modeling refers to the volume of blood pumped by the heart per unit of time, which is used to calculate the rate of blood flow to different organs and tissues in the body</owl:annotatedTarget>
<obo:IAO_0000119>10.3390/ijerph20043473</obo:IAO_0000119>
</owl:Axiom>
<!-- http://si.eu-parc.eu/PKO_0000015 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000015">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000013"/>
<obo:IAO_0000115>Qstomach is a parameter used in PBPK modeling to describe the blood flow rate to the stomach, which is used to calculate the rate of drug/chemical delivery to the stomach. The value of Qstomach depends on the species of interest and is defined by the stomach weight/volume and cardiac output</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>Qstomach</rdfs:label>
</owl:Class>
<!-- http://si.eu-parc.eu/PKO_0000016 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000016">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000015"/>
<obo:IAO_0000115>Fraction of blood flow to stomach</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>FQstomach</rdfs:label>
</owl:Class>
<owl:Axiom>
<owl:annotatedSource rdf:resource="http://si.eu-parc.eu/PKO_0000016"/>
<owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
<owl:annotatedTarget>Fraction of blood flow to stomach</owl:annotatedTarget>
<obo:IAO_0000119>https://doi.org/10.1016/j.toxlet.2023.06.006</obo:IAO_0000119>
</owl:Axiom>
<!-- http://si.eu-parc.eu/PKO_0000017 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000017">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000013"/>
<obo:IAO_0000115>Qintestine is a parameter used in PBPK modeling to describe the blood flow rate to the intestine, which is used to calculate the rate of drug/chemical delivery to the intestine. The value of Qintestine depends on the species of interest and is defined by the intestine weight/volume and cardiac output</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>Qintestine</rdfs:label>
</owl:Class>
<!-- http://si.eu-parc.eu/PKO_0000018 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000018">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000017"/>
<obo:IAO_0000115>Fraction of blood flow to intestine</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>FQintestine</rdfs:label>
</owl:Class>
<owl:Axiom>
<owl:annotatedSource rdf:resource="http://si.eu-parc.eu/PKO_0000018"/>
<owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
<owl:annotatedTarget>Fraction of blood flow to intestine</owl:annotatedTarget>
<obo:IAO_0000119>https://doi.org/10.1016/j.toxlet.2023.06.006</obo:IAO_0000119>
</owl:Axiom>
<!-- http://si.eu-parc.eu/PKO_0000019 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000019">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000013"/>
<obo:IAO_0000115>Qsmall intestine is a parameter used in PBPK modeling to describe the blood flow rate to the small intestine, which is used to calculate the rate of drug/chemical delivery to the small intestine. The value of Qsmall intestine depends on the species of interest and is defined by the small intestine weight/volume and cardiac output</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>Qsmall intestine</rdfs:label>
</owl:Class>
<!-- http://si.eu-parc.eu/PKO_0000020 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000020">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000019"/>
<obo:IAO_0000115>Fraction of blood flow to small intestine</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>FQsmall intestine</rdfs:label>
</owl:Class>
<owl:Axiom>
<owl:annotatedSource rdf:resource="http://si.eu-parc.eu/PKO_0000020"/>
<owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
<owl:annotatedTarget>Fraction of blood flow to small intestine</owl:annotatedTarget>
<obo:IAO_0000119>https://doi.org/10.1016/j.toxlet.2023.06.006</obo:IAO_0000119>
</owl:Axiom>
<!-- http://si.eu-parc.eu/PKO_0000021 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000021">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000013"/>
<obo:IAO_0000115>Qlarge intestine is a parameter used in PBPK modeling to describe the blood flow rate to the large intestine, which is used to calculate the rate of drug/chemical delivery to the large intestine. The value of Qlarge intestine depends on the species of interest and is defined by the large intestine weight/volume and cardiac output</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>Qlarge intestine</rdfs:label>
</owl:Class>
<!-- http://si.eu-parc.eu/PKO_0000022 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000022">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000021"/>
<obo:IAO_0000115>Fraction of blood flow to large intestine</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>FQlarge intestine</rdfs:label>
</owl:Class>
<owl:Axiom>
<owl:annotatedSource rdf:resource="http://si.eu-parc.eu/PKO_0000022"/>
<owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
<owl:annotatedTarget>Fraction of blood flow to large intestine</owl:annotatedTarget>
<obo:IAO_0000119>https://doi.org/10.1016/j.toxlet.2023.06.006</obo:IAO_0000119>
</owl:Axiom>
<!-- http://si.eu-parc.eu/PKO_0000023 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000023">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000013"/>
<obo:IAO_0000115>Qpancreas is a parameter used in PBPK modeling to describe the blood flow rate to the pancreas, which is used to calculate the rate of drug/chemical delivery to the pancreas. The value of Qpancreas depends on the species of interest and is defined by the pancreas weight/volume and cardiac output</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>Qpancreas</rdfs:label>
</owl:Class>
<!-- http://si.eu-parc.eu/PKO_0000024 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000024">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000023"/>
<obo:IAO_0000115>Fraction of blood flow to pancreas</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>FQpancreas</rdfs:label>
</owl:Class>
<owl:Axiom>
<owl:annotatedSource rdf:resource="http://si.eu-parc.eu/PKO_0000024"/>
<owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
<owl:annotatedTarget>Fraction of blood flow to pancreas</owl:annotatedTarget>
<obo:IAO_0000119>https://doi.org/10.1016/j.toxlet.2023.06.006</obo:IAO_0000119>
</owl:Axiom>
<!-- http://si.eu-parc.eu/PKO_0000025 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000025">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000013"/>
<obo:IAO_0000115>Qliver is a parameter used in PBPK modeling to describe the blood flow rate to the liver, which is used to calculate the rate of drug/chemical delivery to the liver. The value of Qliver depends on the species of interest and is defined by the liver weight/volume and cardiac output</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>Qliver</rdfs:label>
</owl:Class>
<owl:Axiom>
<owl:annotatedSource rdf:resource="http://si.eu-parc.eu/PKO_0000025"/>
<owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
<owl:annotatedTarget>Qliver is a parameter used in PBPK modeling to describe the blood flow rate to the liver, which is used to calculate the rate of drug/chemical delivery to the liver. The value of Qliver depends on the species of interest and is defined by the liver weight/volume and cardiac output</owl:annotatedTarget>
<obo:IAO_0000119>10.1002/psp4.12134
https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-reporting-physiologically-based-pharmacokinetic-pbpk-modelling-simulation_en.pdf</obo:IAO_0000119>
</owl:Axiom>
<!-- http://si.eu-parc.eu/PKO_0000026 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000026">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000025"/>
<obo:IAO_0000115>Fraction of blood flow to liver</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>FQliver</rdfs:label>
</owl:Class>
<owl:Axiom>
<owl:annotatedSource rdf:resource="http://si.eu-parc.eu/PKO_0000026"/>
<owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
<owl:annotatedTarget>Fraction of blood flow to liver</owl:annotatedTarget>
<obo:IAO_0000119>https://doi.org/10.1016/j.toxlet.2023.06.006</obo:IAO_0000119>
</owl:Axiom>
<!-- http://si.eu-parc.eu/PKO_0000027 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000027">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000013"/>
<obo:IAO_0000115>Qkidney is a parameter used in PBPK modeling to describe the blood flow rate to the kidney, which is used to calculate the rate of drug/chemical delivery to the kidney. The value of Qkidney depends on the species of interest and is defined by the kidney weight/volume and cardiac output</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>Qkidney</rdfs:label>
</owl:Class>
<!-- http://si.eu-parc.eu/PKO_0000028 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000028">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000027"/>
<obo:IAO_0000115>Fraction of blood flow to kidney</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>FQkidney</rdfs:label>
</owl:Class>
<owl:Axiom>
<owl:annotatedSource rdf:resource="http://si.eu-parc.eu/PKO_0000028"/>
<owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
<owl:annotatedTarget>Fraction of blood flow to kidney</owl:annotatedTarget>
<obo:IAO_0000119>https://doi.org/10.1016/j.toxlet.2023.06.006</obo:IAO_0000119>
</owl:Axiom>
<!-- http://si.eu-parc.eu/PKO_0000029 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000029">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000013"/>
<obo:IAO_0000115>Qmuscle is a parameter used in PBPK modeling to describe the blood flow rate to the muscle, which is used to calculate the rate of drug/chemical delivery to the muscle. The value of Qmuscle depends on the species of interest and is defined by the muscle weight/volume and cardiac output</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>Qmuscle</rdfs:label>
</owl:Class>
<!-- http://si.eu-parc.eu/PKO_0000030 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000030">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000029"/>
<obo:IAO_0000115>Fraction of blood flow to muscle</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>FQmuscle</rdfs:label>
</owl:Class>
<owl:Axiom>
<owl:annotatedSource rdf:resource="http://si.eu-parc.eu/PKO_0000030"/>
<owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
<owl:annotatedTarget>Fraction of blood flow to muscle</owl:annotatedTarget>
<obo:IAO_0000119>https://doi.org/10.1016/j.toxlet.2023.06.006</obo:IAO_0000119>
</owl:Axiom>
<!-- http://si.eu-parc.eu/PKO_0000031 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000031">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000013"/>
<obo:IAO_0000115>Qheart is a parameter used in PBPK modeling to describe the blood flow rate to the heart, which is used to calculate the rate of drug/chemical delivery to the heart. The value of Qheart depends on the species of interest and is defined by the heart weight/volume and cardiac output</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>Qheart</rdfs:label>
</owl:Class>
<!-- http://si.eu-parc.eu/PKO_0000032 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000032">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000031"/>
<obo:IAO_0000115>Fraction of blood flow to heart</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>FQheart</rdfs:label>
</owl:Class>
<owl:Axiom>
<owl:annotatedSource rdf:resource="http://si.eu-parc.eu/PKO_0000032"/>
<owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
<owl:annotatedTarget>Fraction of blood flow to heart</owl:annotatedTarget>
<obo:IAO_0000119>https://doi.org/10.1016/j.toxlet.2023.06.006</obo:IAO_0000119>
</owl:Axiom>
<!-- http://si.eu-parc.eu/PKO_0000033 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000033">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000013"/>
<obo:IAO_0000115>Qfat is a parameter used in PBPK modeling to describe the blood flow rate to the fat, which is used to calculate the rate of drug/chemical delivery to the fat. The value of Qfat depends on the species of interest and is defined by the fat weight/volume and cardiac output</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<obo:IAO_0000605>Qadipose tissue</obo:IAO_0000605>
<rdfs:label>Qfat</rdfs:label>
</owl:Class>
<!-- http://si.eu-parc.eu/PKO_0000034 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000034">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000033"/>
<obo:IAO_0000115>Fraction of blood flow to fat</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>FQfat</rdfs:label>
</owl:Class>
<owl:Axiom>
<owl:annotatedSource rdf:resource="http://si.eu-parc.eu/PKO_0000034"/>
<owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
<owl:annotatedTarget>Fraction of blood flow to fat</owl:annotatedTarget>
<obo:IAO_0000119>https://doi.org/10.1016/j.toxlet.2023.06.006</obo:IAO_0000119>
</owl:Axiom>
<!-- http://si.eu-parc.eu/PKO_0000035 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000035">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000013"/>
<obo:IAO_0000115>Qgonads is a parameter used in PBPK modeling to describe the blood flow rate to the gonads, which is used to calculate the rate of drug/chemical delivery to the gonads. The value of Qgonads depends on the species of interest and is defined by the gonads weight/volume and cardiac output</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>Qgonads</rdfs:label>
</owl:Class>
<!-- http://si.eu-parc.eu/PKO_0000036 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000036">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000035"/>
<obo:IAO_0000115>Fraction of blood flow to gonads</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>FQgonads</rdfs:label>
</owl:Class>
<owl:Axiom>
<owl:annotatedSource rdf:resource="http://si.eu-parc.eu/PKO_0000036"/>
<owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
<owl:annotatedTarget>Fraction of blood flow to gonads</owl:annotatedTarget>
<obo:IAO_0000119>https://doi.org/10.1016/j.toxlet.2023.06.006</obo:IAO_0000119>
</owl:Axiom>
<!-- http://si.eu-parc.eu/PKO_0000037 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000037">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000013"/>
<obo:IAO_0000115>Qskin is a parameter used in PBPK modeling to describe the blood flow rate to the skin, which is used to calculate the rate of drug/chemical delivery to the skin. The value of Qskin depends on the species of interest and is defined by the skin weight/volume and cardiac output</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>Qskin</rdfs:label>
</owl:Class>
<!-- http://si.eu-parc.eu/PKO_0000038 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000038">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000037"/>
<obo:IAO_0000115>Fraction of blood flow to skin</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>FQskin</rdfs:label>
</owl:Class>
<owl:Axiom>
<owl:annotatedSource rdf:resource="http://si.eu-parc.eu/PKO_0000038"/>
<owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
<owl:annotatedTarget>Fraction of blood flow to skin</owl:annotatedTarget>
<obo:IAO_0000119>https://doi.org/10.1016/j.toxlet.2023.06.006</obo:IAO_0000119>
</owl:Axiom>
<!-- http://si.eu-parc.eu/PKO_0000039 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000039">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000013"/>
<obo:IAO_0000115>Qbone is a parameter used in PBPK modeling to describe the blood flow rate to the bone, which is used to calculate the rate of drug/chemical delivery to the bone. The value of Qbone depends on the species of interest and is defined by the bone weight/volume and cardiac output</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>Qbone</rdfs:label>
</owl:Class>
<!-- http://si.eu-parc.eu/PKO_0000040 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000040">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000039"/>
<obo:IAO_0000115>Fraction of blood flow to bone</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>FQbone</rdfs:label>
</owl:Class>
<owl:Axiom>
<owl:annotatedSource rdf:resource="http://si.eu-parc.eu/PKO_0000040"/>
<owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
<owl:annotatedTarget>Fraction of blood flow to bone</owl:annotatedTarget>
<obo:IAO_0000119>https://doi.org/10.1016/j.toxlet.2023.06.006</obo:IAO_0000119>
</owl:Axiom>
<!-- http://si.eu-parc.eu/PKO_0000041 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000041">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000013"/>
<obo:IAO_0000115>Qbrain is a parameter used in PBPK modeling to describe the blood flow rate to the brain, which is used to calculate the rate of drug/chemical delivery to the brain. The value of Qbrain depends on the species of interest and is defined by the brain weight/volume and cardiac output</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>Qbrain</rdfs:label>
</owl:Class>
<!-- http://si.eu-parc.eu/PKO_0000042 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000042">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000041"/>
<obo:IAO_0000115>Fraction of blood flow to brain</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>FQbrain</rdfs:label>
</owl:Class>
<owl:Axiom>
<owl:annotatedSource rdf:resource="http://si.eu-parc.eu/PKO_0000042"/>
<owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
<owl:annotatedTarget>Fraction of blood flow to brain</owl:annotatedTarget>
<obo:IAO_0000119>https://doi.org/10.1016/j.toxlet.2023.06.006</obo:IAO_0000119>
</owl:Axiom>
<!-- http://si.eu-parc.eu/PKO_0000043 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000043">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000013"/>
<obo:IAO_0000115>Qspleen is a parameter used in PBPK modeling to describe the blood flow rate to the spleen, which is used to calculate the rate of drug/chemical delivery to the spleen. The value of Qspleen depends on the species of interest and is defined by the spleen weight/volume and cardiac output</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>Qspleen</rdfs:label>
</owl:Class>
<!-- http://si.eu-parc.eu/PKO_0000044 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000044">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000043"/>
<obo:IAO_0000115>Fraction of blood flow to spleen</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>FQspleen</rdfs:label>
</owl:Class>
<owl:Axiom>
<owl:annotatedSource rdf:resource="http://si.eu-parc.eu/PKO_0000044"/>
<owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
<owl:annotatedTarget>Fraction of blood flow to spleen</owl:annotatedTarget>
<obo:IAO_0000119>https://doi.org/10.1016/j.toxlet.2023.06.006</obo:IAO_0000119>
</owl:Axiom>
<!-- http://si.eu-parc.eu/PKO_0000045 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000045">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000013"/>
<obo:IAO_0000115>Qlung is a parameter used in PBPK modeling to describe the blood flow rate to the lung, which is used to calculate the rate of drug/chemical delivery to the lung. The value of Qlung depends on the species of interest and is defined by the lung weight/volume and cardiac output</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>Qlung</rdfs:label>
</owl:Class>
<!-- http://si.eu-parc.eu/PKO_0000046 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000046">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000045"/>
<obo:IAO_0000115>Fraction of blood flow to lung</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>FQlung</rdfs:label>
</owl:Class>
<owl:Axiom>
<owl:annotatedSource rdf:resource="http://si.eu-parc.eu/PKO_0000046"/>
<owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
<owl:annotatedTarget>Fraction of blood flow to lung</owl:annotatedTarget>
<obo:IAO_0000119>https://doi.org/10.1016/j.toxlet.2023.06.006</obo:IAO_0000119>
</owl:Axiom>
<!-- http://si.eu-parc.eu/PKO_0000047 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000047">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000013"/>
<obo:IAO_0000115>Qpoorly perfused is a parameter used in PBPK modeling to describe the blood flow rate to the poorly perfused organ/tissue, which is used to calculate the rate of drug/chemical delivery to the poorly perfused organ/tissue. The value of Qpoorly perfused depends on the species of interest and is defined by the poorly perfused organ/tissue weight/volume and cardiac output</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>Qpoorly perfused</rdfs:label>
</owl:Class>
<!-- http://si.eu-parc.eu/PKO_0000048 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000048">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000047"/>
<obo:IAO_0000115>Fraction of blood flow to poorly perfused tissues/organ</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>FQpoorly perfused</rdfs:label>
</owl:Class>
<owl:Axiom>
<owl:annotatedSource rdf:resource="http://si.eu-parc.eu/PKO_0000048"/>
<owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
<owl:annotatedTarget>Fraction of blood flow to poorly perfused tissues/organ</owl:annotatedTarget>
<obo:IAO_0000119>https://doi.org/10.1016/j.toxlet.2023.06.006</obo:IAO_0000119>
</owl:Axiom>
<!-- http://si.eu-parc.eu/PKO_0000049 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000049">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000013"/>
<obo:IAO_0000115>Qrichly perfused is a parameter used in PBPK modeling to describe the blood flow rate to the richly perfused organ/tissue, which is used to calculate the rate of drug/chemical delivery to the richly perfused organ/tissue. The value of Qrichly perfused depends on the species of interest and is defined by the richly perfused organ/tissue weight/volume and cardiac output</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>Qrichly perfused</rdfs:label>
</owl:Class>
<!-- http://si.eu-parc.eu/PKO_0000050 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000050">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000049"/>
<obo:IAO_0000115>Fraction of blood flow to richly perfused tissues/organs</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>FQrichly perfused</rdfs:label>
</owl:Class>
<owl:Axiom>
<owl:annotatedSource rdf:resource="http://si.eu-parc.eu/PKO_0000050"/>
<owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
<owl:annotatedTarget>Fraction of blood flow to richly perfused tissues/organs</owl:annotatedTarget>
<obo:IAO_0000119>https://doi.org/10.1016/j.toxlet.2023.06.006</obo:IAO_0000119>
</owl:Axiom>
<!-- http://si.eu-parc.eu/PKO_0000051 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000051">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000013"/>
<obo:IAO_0000115>Qrestbody is a parameter used in PBPK modeling to describe the blood flow rate to the remaining organ/tissue, which is used to calculate the rate of drug/chemical delivery to the remaining organ/tissue. The value of Qrestbody can be obtained by subtracting the total body blood flow with the blood flow of each organs/tissue present in the model.</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>Qrestbody</rdfs:label>
</owl:Class>
<!-- http://si.eu-parc.eu/PKO_0000052 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000052">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000051"/>
<rdfs:label>FQrestbody</rdfs:label>
</owl:Class>
<!-- http://si.eu-parc.eu/PKO_0000053 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000053">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000013"/>
<obo:IAO_0000115>Qgall bladder is a parameter used in PBPK modeling to describe the blood flow rate to the gall bladder, which is used to calculate the rate of drug/chemical delivery to the gall bladder. The value of Qgall bladder depends on the species of interest and is defined by the gall bladder weight/volume and cardiac output</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>Qgallballder</rdfs:label>
</owl:Class>
<!-- http://si.eu-parc.eu/PKO_0000054 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000054">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000053"/>
<rdfs:label>FQgallballder</rdfs:label>
</owl:Class>
<!-- http://si.eu-parc.eu/PKO_0000055 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000055">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000013"/>
<obo:IAO_0000115>Qportal vein is a parameter used in PBPK modeling to describe the blood flow rate to the portal vein, which is used to calculate the rate of drug/chemical delivery to the stomach. The value of Qportal vein depends on the species of interest and is defined by the portal vein weight/volume and cardiac output</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>Qportal vein</rdfs:label>
</owl:Class>
<!-- http://si.eu-parc.eu/PKO_0000056 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000056">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000055"/>
<rdfs:label>FQportal vein</rdfs:label>
</owl:Class>
<!-- http://si.eu-parc.eu/PKO_0000057 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000057">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000013"/>
<obo:IAO_0000115>Qlymph is a parameter used in PBPK modeling to describe the blood flow rate to the lymph, which is used to calculate the rate of drug/chemical delivery to the lymph. The value of Qlymph depends on the species of interest and is defined by the lymph weight/volume and cardiac output</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>Qlymph</rdfs:label>
</owl:Class>
<!-- http://si.eu-parc.eu/PKO_0000058 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000058">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000057"/>
<rdfs:label>FQlymph</rdfs:label>
</owl:Class>
<!-- http://si.eu-parc.eu/PKO_0000059 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000059">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000013"/>
<obo:IAO_0000115>Arterial blood flow in PBPK modeling represents the rate of blood flow to the tissues and organs through the arterial system. This parameter is essential for estimating the distribution of drugs and other substances in the body</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>Arterial blood flow</rdfs:label>
</owl:Class>
<owl:Axiom>
<owl:annotatedSource rdf:resource="http://si.eu-parc.eu/PKO_0000059"/>
<owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
<owl:annotatedTarget>Arterial blood flow in PBPK modeling represents the rate of blood flow to the tissues and organs through the arterial system. This parameter is essential for estimating the distribution of drugs and other substances in the body</owl:annotatedTarget>
<obo:IAO_0000119>10.1007/s40268-020-00325-0
10.1186/1472-6904-4-2</obo:IAO_0000119>
</owl:Axiom>
<!-- http://si.eu-parc.eu/PKO_0000060 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000060">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000013"/>
<obo:IAO_0000115>Venous blood flow in PBPK modeling represents the rate of blood flow returning from the tissues and organs through the venous system. This parameter is essential for estimating the distribution of drugs/chemicals and other substances in the body.</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<rdfs:label>Venous blood flow</rdfs:label>
</owl:Class>
<!-- http://si.eu-parc.eu/PKO_0000061 -->
<owl:Class rdf:about="http://si.eu-parc.eu/PKO_0000061">
<rdfs:subClassOf rdf:resource="http://si.eu-parc.eu/PKO_0000013"/>
<obo:IAO_0000115>Glomerular filtration rate (GFR) is a measure of kidney function that describes the flow rate of filtered fluid through the kidney</obo:IAO_0000115>
<obo:IAO_0000117>0000-0001-8345-1349</obo:IAO_0000117>
<obo:IAO_0000117>0000-0002-9795-5967</obo:IAO_0000117>
<obo:IAO_0000605>GFR</obo:IAO_0000605>
<rdfs:label>Glomerular filtration rate</rdfs:label>
</owl:Class>
<owl:Axiom>
<owl:annotatedSource rdf:resource="http://si.eu-parc.eu/PKO_0000061"/>
<owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
<owl:annotatedTarget>Glomerular filtration rate (GFR) is a measure of kidney function that describes the flow rate of filtered fluid through the kidney</owl:annotatedTarget>
<obo:IAO_0000119>Glomerular filtration rate - Wikipedia</obo:IAO_0000119>
</owl:Axiom>
<!-- http://si.eu-parc.eu/PKO_0000062 -->