diff --git a/efo-base.owl b/efo-base.owl
index 19ff8423..9a4dfe43 100644
--- a/efo-base.owl
+++ b/efo-base.owl
@@ -24495,7 +24495,7 @@ label: abdominal cavity</efo:reason_for_obsolescence>
         <owl:annotatedSource rdf:resource="http://www.ebi.ac.uk/efo/EFO_0000220"/>
         <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
         <owl:annotatedTarget>lymphoblastic leukemia, acute</owl:annotatedTarget>
-        <oboInOwl:hasDbXref>MONDO:patterns/acute</oboInOwl:hasDbXref>
+        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MONDO:patterns/acute</oboInOwl:hasDbXref>
     </owl:Axiom>
     <owl:Axiom>
         <owl:annotatedSource rdf:resource="http://www.ebi.ac.uk/efo/EFO_0000220"/>
@@ -24986,7 +24986,7 @@ label: abdominal cavity</efo:reason_for_obsolescence>
         <owl:annotatedSource rdf:resource="http://www.ebi.ac.uk/efo/EFO_0000221"/>
         <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
         <owl:annotatedTarget>monocytic leukemia, acute</owl:annotatedTarget>
-        <oboInOwl:hasDbXref>MONDO:patterns/acute</oboInOwl:hasDbXref>
+        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MONDO:patterns/acute</oboInOwl:hasDbXref>
     </owl:Axiom>
     <owl:Axiom>
         <owl:annotatedSource rdf:resource="http://www.ebi.ac.uk/efo/EFO_0000221"/>
@@ -25622,7 +25622,7 @@ label: abdominal cavity</efo:reason_for_obsolescence>
         <owl:annotatedSource rdf:resource="http://www.ebi.ac.uk/efo/EFO_0000222"/>
         <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
         <owl:annotatedTarget>myeloid leukemia, acute</owl:annotatedTarget>
-        <oboInOwl:hasDbXref>MONDO:patterns/acute</oboInOwl:hasDbXref>
+        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MONDO:patterns/acute</oboInOwl:hasDbXref>
     </owl:Axiom>
     <owl:Axiom>
         <owl:annotatedSource rdf:resource="http://www.ebi.ac.uk/efo/EFO_0000222"/>
@@ -114681,7 +114681,7 @@ A Jiyoye is bearer of a Burkitt&apos;s lymphoma.</obo:IAO_0000115>
         <owl:annotatedSource rdf:resource="http://www.ebi.ac.uk/efo/EFO_0002422"/>
         <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
         <owl:annotatedTarget>neoplasm (disease), benign</owl:annotatedTarget>
-        <oboInOwl:hasDbXref>MONDO:patterns/benign</oboInOwl:hasDbXref>
+        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MONDO:patterns/benign</oboInOwl:hasDbXref>
     </owl:Axiom>
     <owl:Axiom>
         <owl:annotatedSource rdf:resource="http://www.ebi.ac.uk/efo/EFO_0002422"/>
@@ -397976,15 +397976,15 @@ to hypernasality and abnormal speech reduction.</obo:IAO_0000115>
         <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GARD:16281</oboInOwl:hasDbXref>
         <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MONDO:0060714</oboInOwl:hasDbXref>
         <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">OMIM:617993</oboInOwl:hasDbXref>
-        <oboInOwl:hasExactSynonym>tumoral calcinosis, hyperphosphatemic, familial, 2</oboInOwl:hasExactSynonym>
+        <oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">tumoral calcinosis, hyperphosphatemic, familial, 2</oboInOwl:hasExactSynonym>
         <oboInOwl:hasRelatedSynonym>HFTC2</oboInOwl:hasRelatedSynonym>
-        <oboInOwl:hasRelatedSynonym>tumoral calcinosis, hyperphosphatemic, familial, 2</oboInOwl:hasRelatedSynonym>
+        <oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">tumoral calcinosis, hyperphosphatemic, familial, 2</oboInOwl:hasRelatedSynonym>
         <oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">EFO:0009383</oboInOwl:id>
         <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/mondo#gard_rare"/>
         <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/mondo#nord_rare"/>
         <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/mondo#otar"/>
         <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/mondo#rare"/>
-        <rdfs:label>tumoral calcinosis, hyperphosphatemic, familial, 2</rdfs:label>
+        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">tumoral calcinosis, hyperphosphatemic, familial, 2</rdfs:label>
         <skos:exactMatch rdf:resource="http://identifiers.org/omim/617993"/>
     </owl:Class>
     <owl:Axiom>
@@ -398008,19 +398008,19 @@ to hypernasality and abnormal speech reduction.</obo:IAO_0000115>
     <owl:Axiom>
         <owl:annotatedSource rdf:resource="http://www.ebi.ac.uk/efo/EFO_0009383"/>
         <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
-        <owl:annotatedTarget>tumoral calcinosis, hyperphosphatemic, familial, 2</owl:annotatedTarget>
+        <owl:annotatedTarget rdf:datatype="http://www.w3.org/2001/XMLSchema#string">tumoral calcinosis, hyperphosphatemic, familial, 2</owl:annotatedTarget>
         <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">OMIM:617993</oboInOwl:hasDbXref>
     </owl:Axiom>
     <owl:Axiom>
         <owl:annotatedSource rdf:resource="http://www.ebi.ac.uk/efo/EFO_0009383"/>
         <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
-        <owl:annotatedTarget>tumoral calcinosis, hyperphosphatemic, familial, 2</owl:annotatedTarget>
+        <owl:annotatedTarget rdf:datatype="http://www.w3.org/2001/XMLSchema#string">tumoral calcinosis, hyperphosphatemic, familial, 2</owl:annotatedTarget>
         <rdfs:comment>Mondo preferred label 15.08.2021.</rdfs:comment>
     </owl:Axiom>
     <owl:Axiom>
         <owl:annotatedSource rdf:resource="http://www.ebi.ac.uk/efo/EFO_0009383"/>
         <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
-        <owl:annotatedTarget>tumoral calcinosis, hyperphosphatemic, familial, 2</owl:annotatedTarget>
+        <owl:annotatedTarget rdf:datatype="http://www.w3.org/2001/XMLSchema#string">tumoral calcinosis, hyperphosphatemic, familial, 2</owl:annotatedTarget>
         <rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">preferred label from MONDO</rdfs:comment>
     </owl:Axiom>
     <owl:Axiom>
@@ -398033,7 +398033,7 @@ to hypernasality and abnormal speech reduction.</obo:IAO_0000115>
     <owl:Axiom>
         <owl:annotatedSource rdf:resource="http://www.ebi.ac.uk/efo/EFO_0009383"/>
         <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
-        <owl:annotatedTarget>tumoral calcinosis, hyperphosphatemic, familial, 2</owl:annotatedTarget>
+        <owl:annotatedTarget rdf:datatype="http://www.w3.org/2001/XMLSchema#string">tumoral calcinosis, hyperphosphatemic, familial, 2</owl:annotatedTarget>
         <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">OMIM:617993</oboInOwl:hasDbXref>
     </owl:Axiom>
     <owl:Axiom>
@@ -543507,6 +543507,22 @@ Smart-seq3 is a continuation and improvement of the Smart-seq technology, specif
     
 
 
+    <!-- http://www.ebi.ac.uk/efo/EFO_0803689 -->
+
+    <owl:Class rdf:about="http://www.ebi.ac.uk/efo/EFO_0803689">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0009410"/>
+        <obo:IAO_0000115>A trait that affects the response to a stimulus with traditional medicine products.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">trait in response to traditional medicine</rdfs:label>
+    </owl:Class>
+    <owl:Axiom>
+        <owl:annotatedSource rdf:resource="http://www.ebi.ac.uk/efo/EFO_0803689"/>
+        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
+        <owl:annotatedTarget>A trait that affects the response to a stimulus with traditional medicine products.</owl:annotatedTarget>
+        <efo:definition_citation>PMID:36583370</efo:definition_citation>
+    </owl:Axiom>
+    
+
+
     <!-- http://www.ebi.ac.uk/efo/EFO_1000003 -->
 
     <owl:Class rdf:about="http://www.ebi.ac.uk/efo/EFO_1000003">
@@ -546004,7 +546020,7 @@ A syndrome typically consisting of angina (cardiac chest pain) at rest that occu
         <owl:annotatedSource rdf:resource="http://www.ebi.ac.uk/efo/EFO_1000028"/>
         <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
         <owl:annotatedTarget>ependymoma, benign</owl:annotatedTarget>
-        <oboInOwl:hasDbXref>MONDO:patterns/benign</oboInOwl:hasDbXref>
+        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MONDO:patterns/benign</oboInOwl:hasDbXref>
     </owl:Axiom>
     <owl:Axiom>
         <owl:annotatedSource rdf:resource="http://www.ebi.ac.uk/efo/EFO_1000028"/>
@@ -546035,7 +546051,7 @@ A syndrome typically consisting of angina (cardiac chest pain) at rest that occu
         <owl:annotatedSource rdf:resource="http://www.ebi.ac.uk/efo/EFO_1000028"/>
         <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym"/>
         <owl:annotatedTarget>ependymoma, benign</owl:annotatedTarget>
-        <oboInOwl:hasDbXref>MONDO:patterns/benign</oboInOwl:hasDbXref>
+        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MONDO:patterns/benign</oboInOwl:hasDbXref>
     </owl:Axiom>
     <owl:Axiom>
         <owl:annotatedSource rdf:resource="http://www.ebi.ac.uk/efo/EFO_1000028"/>
@@ -551086,7 +551102,7 @@ Label : Disorder of carbohydrate metabolism</efo:reason_for_obsolescence>
         <owl:annotatedSource rdf:resource="http://www.ebi.ac.uk/efo/EFO_1000062"/>
         <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
         <owl:annotatedTarget rdf:datatype="http://www.w3.org/2001/XMLSchema#string">lactase persistence</owl:annotatedTarget>
-        <oboInOwl:hasDbXref>OMIM:223100</oboInOwl:hasDbXref>
+        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">OMIM:223100</oboInOwl:hasDbXref>
     </owl:Axiom>
     <owl:Axiom>
         <owl:annotatedSource rdf:resource="http://www.ebi.ac.uk/efo/EFO_1000062"/>
@@ -558017,7 +558033,7 @@ Label : Disorder of carbohydrate metabolism</efo:reason_for_obsolescence>
         <owl:annotatedSource rdf:resource="http://www.ebi.ac.uk/efo/EFO_1000106"/>
         <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
         <owl:annotatedTarget>adrenal gland pheochromocytoma, benign</owl:annotatedTarget>
-        <oboInOwl:hasDbXref>MONDO:patterns/benign</oboInOwl:hasDbXref>
+        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MONDO:patterns/benign</oboInOwl:hasDbXref>
     </owl:Axiom>
     <owl:Axiom>
         <owl:annotatedSource rdf:resource="http://www.ebi.ac.uk/efo/EFO_1000106"/>
@@ -558310,7 +558326,7 @@ Label : Disorder of carbohydrate metabolism</efo:reason_for_obsolescence>
         <owl:annotatedSource rdf:resource="http://www.ebi.ac.uk/efo/EFO_1000108"/>
         <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
         <owl:annotatedTarget>carotid body paraganglioma, benign</owl:annotatedTarget>
-        <oboInOwl:hasDbXref>MONDO:patterns/benign</oboInOwl:hasDbXref>
+        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MONDO:patterns/benign</oboInOwl:hasDbXref>
     </owl:Axiom>
     <owl:Axiom>
         <owl:annotatedSource rdf:resource="http://www.ebi.ac.uk/efo/EFO_1000108"/>
@@ -595867,7 +595883,7 @@ Label : malignant epithelioid mesothelioma</efo:reason_for_obsolescence>
         <owl:annotatedSource rdf:resource="http://www.ebi.ac.uk/efo/EFO_1000364"/>
         <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
         <owl:annotatedTarget>sarcoma of mast cell</owl:annotatedTarget>
-        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MONDO:patterns/sarcoma</oboInOwl:hasDbXref>
+        <oboInOwl:hasDbXref>MONDO:patterns/sarcoma</oboInOwl:hasDbXref>
     </owl:Axiom>
     <owl:Axiom>
         <owl:annotatedSource rdf:resource="http://www.ebi.ac.uk/efo/EFO_1000364"/>
@@ -612115,7 +612131,7 @@ Use: http://www.ebi.ac.uk/efo/EFO_0000197 Label: mucinous carcinoma</efo:reason_
         <owl:annotatedSource rdf:resource="http://www.ebi.ac.uk/efo/EFO_1000485"/>
         <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym"/>
         <owl:annotatedTarget>pleural mesothelioma (disease), benign</owl:annotatedTarget>
-        <oboInOwl:hasDbXref>MONDO:patterns/benign</oboInOwl:hasDbXref>
+        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MONDO:patterns/benign</oboInOwl:hasDbXref>
     </owl:Axiom>
     <owl:Axiom>
         <owl:annotatedSource rdf:resource="http://www.ebi.ac.uk/efo/EFO_1000485"/>
@@ -694395,7 +694411,7 @@ Label: Moebius syndrome</efo:reason_for_obsolescence>
         <owl:annotatedSource rdf:resource="http://www.ebi.ac.uk/efo/EFO_1001080"/>
         <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
         <owl:annotatedTarget>pulmonary sulcus neoplasm, malignant</owl:annotatedTarget>
-        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MONDO:patterns/malignant</oboInOwl:hasDbXref>
+        <oboInOwl:hasDbXref>MONDO:patterns/malignant</oboInOwl:hasDbXref>
     </owl:Axiom>
     <owl:Axiom>
         <owl:annotatedSource rdf:resource="http://www.ebi.ac.uk/efo/EFO_1001080"/>
diff --git a/src/ontology/efo-edit.owl b/src/ontology/efo-edit.owl
index 5b1a1c5e..3592d51e 100644
--- a/src/ontology/efo-edit.owl
+++ b/src/ontology/efo-edit.owl
@@ -20998,6 +20998,7 @@ Declaration(Class(efo:EFO_0803685))
 Declaration(Class(efo:EFO_0803686))
 Declaration(Class(efo:EFO_0803687))
 Declaration(Class(efo:EFO_0803688))
+Declaration(Class(efo:EFO_0803689))
 Declaration(Class(efo:EFO_1000003))
 Declaration(Class(efo:EFO_1000012))
 Declaration(Class(efo:EFO_1000013))
@@ -29554,7 +29555,7 @@ AnnotationAssertion(rdfs:label obo:RO_0001025 "located_in")
 
 AnnotationAssertion(rdfs:label obo:RO_0002104 "has_plasma_membrane_part")
 
-# Object Property: obo:RO_0002160 (only in taxon)
+# Object Property: obo:RO_0002160 (only_in_taxon)
 
 AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:20973947") obo:IAO_0000115 obo:RO_0002160 "S only_in_taxon T iff: S SubClassOf in_taxon only T")
 AnnotationAssertion(oboInOwl:hasDbXref obo:RO_0002160 "RO:0002160")
@@ -237350,6 +237351,12 @@ AnnotationAssertion(rdfs:comment efo:EFO_0803688 "Review for potential replaceme
 AnnotationAssertion(rdfs:label efo:EFO_0803688 "SARS coronavirus seropositivity")
 SubClassOf(efo:EFO_0803688 efo:EFO_0803595)
 
+# Class: efo:EFO_0803689 (trait in response to traditional medicine)
+
+AnnotationAssertion(Annotation(efo:definition_citation "PMID:36583370") obo:IAO_0000115 efo:EFO_0803689 "A trait that affects the response to a stimulus with traditional medicine products.")
+AnnotationAssertion(rdfs:label efo:EFO_0803689 "trait in response to traditional medicine"@en)
+SubClassOf(efo:EFO_0803689 obo:GO_0009410)
+
 # Class: efo:EFO_1000003 (Zinc deficiency)
 
 AnnotationAssertion(obo:IAO_0000115 efo:EFO_1000003 "A deficiency of the essential metal Zinc; an essential cofactor for many enzymes. Zinc deficiency is caused by a lack of zinc in the diet, loss of zinc after absorption, for example through loss through burns, inability to absorb Zinc, or increased loss through exercise. ")