Developing PySide6 with Jetbrains PyCharm

Download and install PyCharm Community
Start PyCharm and open pyside6-getting-started:

Click Ok to setup virtual environment:

To configure the Python environment manually, go to File | Settings | Project | Python Interpreter:

Wait until progress bar on the bottom is completed.
Open a Python file from the Project tab and set a breakpoint and click the debug icon:

Use the F9..F11 keys to step through the code: