diff --git a/nixos/modules/services/desktops/pipewire/wireplumber.nix b/nixos/modules/services/desktops/pipewire/wireplumber.nix
index 009d68bd4f28d..5967ac36fa85f 100644
--- a/nixos/modules/services/desktops/pipewire/wireplumber.nix
+++ b/nixos/modules/services/desktops/pipewire/wireplumber.nix
@@ -56,24 +56,28 @@ in
 
   config =
     let
-      pwNotForAudioConfigPkg = pkgs.writeTextDir "share/wireplumber/main.lua.d/80-pw-not-for-audio.lua" ''
-        -- PipeWire is not used for audio, so prevent it from grabbing audio devices
-        alsa_monitor.enable = function() end
-      '';
-      systemwideConfigPkg = pkgs.writeTextDir "share/wireplumber/main.lua.d/80-systemwide.lua" ''
-        -- When running system-wide, these settings need to be disabled (they
-        -- use functions that aren't available on the system dbus).
-        alsa_monitor.properties["alsa.reserve"] = false
-        default_access.properties["enable-flatpak-portal"] = false
+      pwNotForAudioConfigPkg = pkgs.writeTextDir "share/wireplumber/wireplumber.conf.d/90-nixos-no-audio.conf" ''
+        # PipeWire is not used for audio, so WirePlumber should not be handling it
+        wireplumber.profiles = {
+          main = {
+            hardware.audio = disabled
+            hardware.bluetooth = disabled
+          }
+        }
       '';
-      systemwideBluetoothConfigPkg = pkgs.writeTextDir "share/wireplumber/bluetooth.lua.d/80-systemwide.lua" ''
-        -- When running system-wide, logind-integration needs to be disabled.
-        bluez_monitor.properties["with-logind"] = false
+
+      systemwideConfigPkg = pkgs.writeTextDir "share/wireplumber/wireplumber.conf.d/90-nixos-systemwide.conf" ''
+        # When running system-wide, we don't have logind to call ReserveDevice
+        wireplumber.profiles = {
+          main = {
+            support.reserve-device = disabled
+          }
+        }
       '';
 
       configPackages = cfg.configPackages
           ++ lib.optional (!pwUsedForAudio) pwNotForAudioConfigPkg
-          ++ lib.optionals config.services.pipewire.systemWide [ systemwideConfigPkg systemwideBluetoothConfigPkg ];
+          ++ lib.optional config.services.pipewire.systemWide systemwideConfigPkg;
 
       configs = pkgs.buildEnv {
         name = "wireplumber-configs";
diff --git a/pkgs/development/libraries/pipewire/wireplumber.nix b/pkgs/development/libraries/pipewire/wireplumber.nix
index a5bdb729a102b..c60ac184978a1 100644
--- a/pkgs/development/libraries/pipewire/wireplumber.nix
+++ b/pkgs/development/libraries/pipewire/wireplumber.nix
@@ -24,7 +24,7 @@
 
 stdenv.mkDerivation rec {
   pname = "wireplumber";
-  version = "0.4.17";
+  version = "0.5.0";
 
   outputs = [ "out" "dev" ] ++ lib.optional enableDocs "doc";
 
@@ -33,7 +33,7 @@ stdenv.mkDerivation rec {
     owner = "pipewire";
     repo = "wireplumber";
     rev = version;
-    hash = "sha256-vhpQT67+849WV1SFthQdUeFnYe/okudTQJoL3y+wXwI=";
+    hash = "sha256-zcYZvyGsGuiwuL9nOD5mW6RFwa9cPB9HvoQqdw2jlmY=";
   };
 
   nativeBuildInputs = [