-
Notifications
You must be signed in to change notification settings - Fork 1
/
init.ses
236 lines (231 loc) · 6.16 KB
/
init.ses
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
{load_file("nrngui.hoc")}
objectvar save_window_, rvp_
objectvar scene_vector_[6]
objectvar ocbox_, ocbox_list_, scene_, scene_list_
{ocbox_list_ = new List() scene_list_ = new List()}
{pwman_place(0,0,0)}
//Begin PointProcessManager
{
load_file("pointman.hoc")
}
{
soma ocbox_ = new PointProcessManager(0)
}
{object_push(ocbox_)}
{
mt.select("NIClamp") i = mt.selected()
ms[i] = new MechanismStandard("NIClamp")
ms[i].set("del", 100, 0)
ms[i].set("dur", 1, 0)
ms[i].set("amp", 2, 0)
ms[i].set("del1", 1000, 0)
ms[i].set("n", 100, 0)
mt.select("NIClamp") i = mt.selected() maction(i)
hoc_ac_ = 0.5
sec.sec move() d1.flip_to(0)
}
{object_pop() doNotify()}
{
ocbox_ = ocbox_.v1
ocbox_.map("PointProcessManager", 450, 0, 200, 200)
}
objref ocbox_
//End PointProcessManager
//Begin Insert/Remove Mechanisms
{
load_file("inserter.hoc", "Inserter")
}
{
soma ocbox_ = new Inserter(0)
}
{object_push(ocbox_)}
{
mt.select("pas") i = mt.selected()
ms[i] = new MechanismStandard("pas")
ms[i].set("g_pas", 0.001, 0)
ms[i].set("e_pas", -70, 0)
mstate[i]= 0
mt.select("hh") i = mt.selected()
ms[i] = new MechanismStandard("hh")
ms[i].set("gnabar_hh", 0.12, 0)
ms[i].set("gkbar_hh", 0.036, 0)
ms[i].set("gl_hh", 0.0003, 0)
ms[i].set("el_hh", -54.3, 0)
mstate[i]= 0
mt.select("Cadynam") i = mt.selected()
ms[i] = new MechanismStandard("Cadynam")
mstate[i]= 1
maction(i)
mt.select("IK1") i = mt.selected()
ms[i] = new MechanismStandard("IK1")
ms[i].set("gK1_IK1", 0.00035, 0)
mstate[i]= 1
maction(i)
mt.select("INa") i = mt.selected()
ms[i] = new MechanismStandard("INa")
ms[i].set("gnabar_INa", 0.004, 0)
ms[i].set("gnac_INa", 3e-06, 0)
ms[i].set("Tauact_INa", 1, 0)
ms[i].set("Tauinactf_INa", 1, 0)
ms[i].set("Tauinacts_INa", 1, 0)
mstate[i]= 1
maction(i)
mt.select("Is") i = mt.selected()
ms[i] = new MechanismStandard("Is")
ms[i].set("gsbar_Is", 5e-05, 0)
mstate[i]= 1
maction(i)
mt.select("IKx1") i = mt.selected()
ms[i] = new MechanismStandard("IKx1")
ms[i].set("gx1_IKx1", 0.0008, 0)
ms[i].set("Tauact_IKx1", 1, 0)
mstate[i]= 1
maction(i)
mt.select("K_acc") i = mt.selected()
ms[i] = new MechanismStandard("K_acc")
ms[i].set("Vi_K_acc", 1.3668e-08, 0)
ms[i].set("ik_K_acc", 0.000445123, 0)
ms[i].set("Kneutral_K_acc", 3e-05, 0)
mstate[i]= 1
maction(i)
mt.select("Na_acc") i = mt.selected()
ms[i] = new MechanismStandard("Na_acc")
ms[i].set("Naneutral_Na_acc", 3e-05, 0)
ms[i].set("Vi_Na_acc", 1.3668e-08, 0)
mstate[i]= 1
maction(i)
}
{object_pop() doNotify()}
{
ocbox_ = ocbox_.v1
ocbox_.map("Insert/Remove Mechanisms", 300, 0, 100, 160)
}
objref ocbox_
//End Insert/Remove Mechanisms
{
xpanel("ca_ion (Globals)", 0)
cai0_ca_ion = 1e-07
xvalue("cai0_ca_ion","cai0_ca_ion", 1,"", 0, 0 )
cao0_ca_ion = 1.8
xvalue("cao0_ca_ion","cao0_ca_ion", 1,"", 0, 0 )
xpanel(800,0)
}
{
xpanel("k_ion (Globals)", 0)
ki0_k_ion = 141.59
xvalue("ki0_k_ion","ki0_k_ion", 1,"", 0, 0 )
ko0_k_ion = 5.4
xvalue("ko0_k_ion","ko0_k_ion", 1,"", 0, 0 )
xpanel(800,100)
}
{
save_window_ = new Graph(0)
save_window_.size(0,5600,-100,40)
scene_vector_[3] = save_window_
{save_window_.view(0, -100, 5600, 140, 0, 606, 1026, 203.5)}
graphList[0].append(save_window_)
save_window_.save_name("graphList[0].")
save_window_.addexpr("v(.5)", 2, 1, 0.8, 0.9, 2)
}
{
xpanel("na_ion (Globals)", 0)
nai0_na_ion = 20
xvalue("nai0_na_ion","nai0_na_ion", 1,"", 0, 0 )
nao0_na_ion = 140
xvalue("nao0_na_ion","nao0_na_ion", 1,"", 0, 0 )
xpanel(800,200)
}
{
xpanel("soma(0 - 1) (Parameters)", 0)
xlabel("soma(0 - 1) (Parameters)")
xlabel("nseg = 1")
soma.L = 100
xvalue("L","soma.L", 1,"define_shape()", 0, 0 )
soma.diam = 16
xvalue("diam","soma.diam", 1,"", 0, 0 )
soma.cm = 1
xvalue("cm","soma.cm", 1,"", 0, 0 )
xpanel(650,0)
}
{
xpanel("RunControl", 0)
v_init = -75
xvalue("Init","v_init", 1,"stdinit()", 1, 1 )
xbutton("Init & Run","run()")
xbutton("Stop","stoprun=1")
runStopAt = 5
xvalue("Continue til","runStopAt", 1,"{continuerun(runStopAt) stoprun=1}", 1, 1 )
runStopIn = 1000
xvalue("Continue for","runStopIn", 1,"{continuerun(t + runStopIn) stoprun=1}", 1, 1 )
xbutton("Single Step","steprun()")
t = 5600
xvalue("t","t", 2 )
tstop = 5600
xvalue("Tstop","tstop", 1,"tstop_changed()", 0, 1 )
dt = 26.6033
xvalue("dt","dt", 1,"setdt()", 0, 1 )
steps_per_ms = 1
xvalue("Points plotted/ms","steps_per_ms", 1,"setdt()", 0, 1 )
xcheckbox("Quiet",&stdrun_quiet,"")
realtime = 0.45
xvalue("Real Time","realtime", 0,"", 0, 1 )
xpanel(0,100)
}
{
xpanel("soma(0 - 1) (Parameters)", 0)
xlabel("soma(0 - 1) (Parameters)")
xlabel("nseg = 1")
soma.L = 100
xvalue("L","soma.L", 1,"define_shape()", 0, 0 )
soma.diam = 16
xvalue("diam","soma.diam", 1,"", 0, 0 )
soma.cm = 1
xvalue("cm","soma.cm", 1,"", 0, 0 )
soma.gK1_IK1 = 0.00035
xvalue("gK1_IK1","soma.gK1_IK1", 1,"", 0, 0 )
soma.gnabar_INa = 0.004
xvalue("gnabar_INa","soma.gnabar_INa", 1,"", 0, 0 )
soma.gnac_INa = 3e-06
xvalue("gnac_INa","soma.gnac_INa", 1,"", 0, 0 )
soma.Tauact_INa = 1
xvalue("Tauact_INa","soma.Tauact_INa", 1,"", 0, 0 )
soma.Tauinactf_INa = 1
xvalue("Tauinactf_INa","soma.Tauinactf_INa", 1,"", 0, 0 )
soma.Tauinacts_INa = 1
xvalue("Tauinacts_INa","soma.Tauinacts_INa", 1,"", 0, 0 )
soma.ena = 51.8691
xvalue("ena","soma.ena", 1,"", 0, 0 )
soma.gsbar_Is = 5e-05
xvalue("gsbar_Is","soma.gsbar_Is", 1,"", 0, 0 )
soma.gx1_IKx1 = 0.0008
xvalue("gx1_IKx1","soma.gx1_IKx1", 1,"", 0, 0 )
soma.Tauact_IKx1 = 1
xvalue("Tauact_IKx1","soma.Tauact_IKx1", 1,"", 0, 0 )
soma.ek = -87.2343
xvalue("ek","soma.ek", 1,"", 0, 0 )
xpanel(1000,0)
}
{
save_window_ = new Graph(0)
save_window_.size(4000,4600,0,1)
scene_vector_[4] = save_window_
{save_window_.view(4000, 0, 600, 1, 722, 268, 300.6, 200.8)}
graphList[2].append(save_window_)
save_window_.save_name("graphList[2].")
save_window_.addvar("soma.m_INa( 0.5 )", 2, 1, 0.8, 0.9, 2)
save_window_.addvar("soma.n_INa( 0.5 )", 1, 1, 0.8, 0.9, 2)
save_window_.addvar("soma.h_INa( 0.5 )", 3, 1, 0.8, 0.9, 2)
}
{
save_window_ = new Graph(0)
save_window_.size(4000,4600,0,1)
scene_vector_[5] = save_window_
{save_window_.view(4000, 0, 600, 1, 301, 267, 300.6, 200.8)}
graphList[2].append(save_window_)
save_window_.save_name("graphList[2].")
save_window_.addvar("soma.n_Is( 0.5 )", 3, 1, 0.8, 0.9, 2)
save_window_.addvar("soma.m_IKx1( 0.5 )", 2, 1, 0.8, 0.9, 2)
save_window_.addvar("soma.m_Is( 0.5 )", 1, 1, 0.8, 0.9, 2)
}
objectvar scene_vector_[1]
{doNotify()}