Contrast agents fMRI #83
SjoerdMurris
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Hi Sjoerd,
We use BioPal as well (and also used to use Feraheme).
Best,
~Theresa
—
Theresa M. Desrochers, Ph.D.
Rosenberg Assistant Professor of Brain Science
Department of Neuroscience
Department of Psychiatry and Human Behavior (courtesy)
Carney Institute for Brain Science
Brown University
http://neuroscience.brown.edu/desrochers
… On Jan 12, 2024, at 3:48 AM, 'SjoerdMurris' via NHP-MRI ***@***.***> wrote:
Hi everyone,
We're planning to start fMRI experiments soon-ish here in Amsterdam. We previously have only done BOLD scans here, but I've done CBV scans before in Leuven, injecting a contrast agent (MION) before scanning. We have an old batch of Feraheme lying around, which has expired. We're a bit hesitant in using it, since Feraheme is advising against it (even after emphasizing it's not for clinical purposes). I was always under the impression that these contrast agents do not expire, but something to do with particle size and microbiological purity, who knows..
In any case, we're thinking of ordering new vials through BioPal, which I know they also order from at my old group in Leuven. But before I do so, I thought it would be nice to reach out and see what other people are using these days?
All the best,
Sjoerd
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You may want to check with your vets. Here in the US it is not permitted to use expired drugs in monkeys or any animals .Michele On Jan 12, 2024, at 3:48 AM, 'SjoerdMurris' via NHP-MRI ***@***.***> wrote:
Hi everyone,
We're planning to start fMRI experiments soon-ish here in Amsterdam. We previously have only done BOLD scans here, but I've done CBV scans before in Leuven, injecting a contrast agent (MION) before scanning. We have an old batch of Feraheme lying around, which has expired. We're a bit hesitant in using it, since Feraheme is advising against it (even after emphasizing it's not for clinical purposes). I was always under the impression that these contrast agents do not expire, but something to do with particle size and microbiological purity, who knows..
In any case, we're thinking of ordering new vials through BioPal, which I know they also order from at my old group in Leuven. But before I do so, I thought it would be nice to reach out and see what other people are using these days?
All the best,
Sjoerd
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Hi Sjeord, As with Theresa, I've used both Feraheme and MOLDAY. my best understanding is that because Feraheme is/was designed as an clinical iron supplement not just a contrast agent it more easily binds to tissue and sticks around. I have seen this first hand where we see significant dropout after only a few sessions with Feraheme, whereas MOLDAY appears to clear much more quickly and thoroughly. If you have the option to switch to Biopal's MOLDAY I would recommend it. Otherwise you may want to pay even greater attention to changes in signal across sessions. |
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Hi everyone,
We're planning to start fMRI experiments soon-ish here in Amsterdam. We previously have only done BOLD scans here, but I've done CBV scans before in Leuven, injecting a contrast agent (MION) before scanning. We have an old batch of Feraheme lying around, which has expired. We're a bit hesitant in using it, since Feraheme is advising against it (even after emphasizing it's not for clinical purposes). I was always under the impression that these contrast agents do not expire, but something to do with particle size and microbiological purity, who knows..
In any case, we're thinking of ordering new vials through BioPal, which I know they also order from at my old group in Leuven. But before I do so, I thought it would be nice to reach out and see what other people are using these days?
All the best,
Sjoerd
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