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what about fold change? #12

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colin986 opened this issue Apr 6, 2024 · 0 comments

colin986 commented Apr 6, 2024

Hi,

Thanks for producing this code, it's very useful.

When assessing the different classes of regulation a change is considered significant if the adjusted p < 0.05.

But what about biological significance? Is there a reason why fold change isn't incorporated?

It is possible that that genes could be significant based on the p-value but the fold change is e.g. < log2(1.2) or log2(1.5)

Any input here is appreciated,
Colin

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