diff --git a/include/tquic.h b/include/tquic.h
index d09c2231..68029152 100644
--- a/include/tquic.h
+++ b/include/tquic.h
@@ -966,6 +966,21 @@ void quic_conn_session(struct quic_conn_t *conn, const uint8_t **out, size_t *ou
  */
 int quic_conn_early_data_reason(struct quic_conn_t *conn, const uint8_t **out, size_t *out_len);
 
+/**
+ * Send a Ping frame on the active path(s) for keep-alive.
+ */
+int quic_conn_ping(struct quic_conn_t *conn);
+
+/**
+ * Send a Ping frame on the specified path for keep-alive.
+ * The API is only applicable to multipath quic connections.
+ */
+int quic_conn_ping_path(struct quic_conn_t *conn,
+                        const struct sockaddr *local,
+                        socklen_t local_len,
+                        const struct sockaddr *remote,
+                        socklen_t remote_len);
+
 /**
  * Add a new path on the client connection.
  */
diff --git a/src/connection/connection.rs b/src/connection/connection.rs
index 5679aafd..d3c2000d 100644
--- a/src/connection/connection.rs
+++ b/src/connection/connection.rs
@@ -1843,11 +1843,15 @@ impl Connection {
         self.try_write_new_token_frame(out, st, pkt_type, path_id)?;
 
         // Write a PING frame
-        if st.ack_elicit_required && !st.ack_eliciting && !self.is_closing() {
+        if ((st.ack_elicit_required && !st.ack_eliciting)
+            || self.paths.get_mut(path_id)?.need_send_ping)
+            && !self.is_closing()
+        {
             let frame = Frame::Ping { pmtu_probe: None };
             Connection::write_frame_to_packet(frame, out, st)?;
             st.ack_eliciting = true;
             st.in_flight = true;
+            self.paths.get_mut(path_id)?.need_send_ping = false;
         }
 
         // No frames to be sent
@@ -2832,6 +2836,9 @@ impl Connection {
                         if space.need_send_buffered_frames() && path.recovery.can_send() {
                             return Ok(pid);
                         }
+                        if path.need_send_ping {
+                            return Ok(pid);
+                        }
                         continue;
                     }
                     None => continue,
@@ -2924,6 +2931,7 @@ impl Connection {
                 || self.local_error.as_ref().map_or(false, |e| e.is_app)
                 || path.need_send_validation_frames(self.is_server)
                 || path.dplpmtud.should_probe()
+                || path.need_send_ping
                 || self.cids.need_send_cid_control_frames()
                 || self.streams.need_send_stream_frames()
                 || self.spaces.need_send_buffered_frames())
@@ -3499,6 +3507,14 @@ impl Connection {
         })
     }
 
+    /// Send a Ping frame for keep-alive.
+    ///
+    /// If `path_addr` is `None`, a Ping frame will be sent on each active path.
+    /// Otherwise, a Ping frame will be on the specified path.
+    pub fn ping(&mut self, path_addr: Option<FourTuple>) -> Result<()> {
+        self.paths.mark_ping(path_addr)
+    }
+
     /// Client add a new path on the connection.
     pub fn add_path(&mut self, local_addr: SocketAddr, remote_addr: SocketAddr) -> Result<u64> {
         if self.is_server {
@@ -5940,6 +5956,46 @@ pub(crate) mod tests {
         Ok(())
     }
 
+    #[test]
+    fn ping() -> Result<()> {
+        let mut client_config = TestPair::new_test_config(false)?;
+        client_config.enable_dplpmtud(false);
+        client_config.local_transport_params = TransportParams {
+            max_idle_timeout: 15000,
+            ..TransportParams::default()
+        };
+        let mut server_config = TestPair::new_test_config(true)?;
+        server_config.enable_dplpmtud(false);
+        server_config.local_transport_params = TransportParams {
+            max_idle_timeout: 15000,
+            ..TransportParams::default()
+        };
+        let mut test_pair = TestPair::new(&mut client_config, &mut server_config)?;
+        test_pair.handshake()?;
+
+        // Move both connections to idle state
+        test_pair.move_forward()?;
+
+        // Enable qlog for Server
+        let slog = NamedTempFile::new().unwrap();
+        let mut sfile = slog.reopen().unwrap();
+        test_pair
+            .server
+            .set_qlog(Box::new(slog), "title".into(), "desc".into());
+
+        // Client send a Ping frame
+        test_pair.client.ping(None)?;
+        let packets = TestPair::conn_packets_out(&mut test_pair.client)?;
+        TestPair::conn_packets_in(&mut test_pair.server, packets.clone())?;
+
+        let mut slog_content = String::new();
+        sfile.read_to_string(&mut slog_content).unwrap();
+        assert_eq!(slog_content.contains("quic:packet_received"), true);
+        assert_eq!(slog_content.contains("frame_type\":\"ping"), true);
+
+        Ok(())
+    }
+
     #[test]
     fn conn_basic_operations() -> Result<()> {
         let mut test_pair = TestPair::new_with_zero_cid()?;
diff --git a/src/connection/path.rs b/src/connection/path.rs
index 87c8a9aa..c5238f63 100644
--- a/src/connection/path.rs
+++ b/src/connection/path.rs
@@ -28,6 +28,7 @@ use super::timer;
 use crate::connection::SpaceId;
 use crate::error::Error;
 use crate::multipath_scheduler::MultipathScheduler;
+use crate::FourTuple;
 use crate::PathStats;
 use crate::RecoveryConfig;
 use crate::Result;
@@ -92,6 +93,9 @@ pub struct Path {
     /// The current pmtu probing state of the path.
     pub(super) dplpmtud: Dplpmtud,
 
+    /// Whether a Ping frame should be sent on the path.
+    pub(super) need_send_ping: bool,
+
     /// Trace id.
     trace_id: String,
 
@@ -140,6 +144,7 @@ impl Path {
             peer_verified_local_address: false,
             anti_ampl_limit: 0,
             dplpmtud,
+            need_send_ping: false,
             trace_id: trace_id.to_string(),
             space_id: SpaceId::Data,
             is_abandon: false,
@@ -607,6 +612,33 @@ impl PathMap {
         left
     }
 
+    /// Schedule a Ping frame on the specified path or all active paths.
+    pub fn mark_ping(&mut self, path_addr: Option<FourTuple>) -> Result<()> {
+        // If multipath is not enabled, schedule a Ping frame on the current
+        // active path.
+        if !self.is_multipath {
+            self.get_active_mut()?.need_send_ping = true;
+            return Ok(());
+        }
+
+        // If multipath is enabled, schedule a Ping frame on the specified path
+        // or all the active paths.
+        if let Some(a) = path_addr {
+            let pid = match self.get_path_id(&(a.local, a.remote)) {
+                Some(pid) => pid,
+                None => return Ok(()),
+            };
+            self.get_mut(pid)?.need_send_ping = true;
+            return Ok(());
+        }
+        for (_, path) in self.paths.iter_mut() {
+            if path.active() {
+                path.need_send_ping = true;
+            }
+        }
+        Ok(())
+    }
+
     /// Promote to multipath mode.
     pub fn enable_multipath(&mut self) {
         self.is_multipath = true;
diff --git a/src/ffi.rs b/src/ffi.rs
index 987e01d0..d9fda126 100644
--- a/src/ffi.rs
+++ b/src/ffi.rs
@@ -1048,6 +1048,35 @@ pub extern "C" fn quic_conn_early_data_reason(
     }
 }
 
+/// Send a Ping frame on the active path(s) for keep-alive.
+#[no_mangle]
+pub extern "C" fn quic_conn_ping(conn: &mut Connection) -> c_int {
+    match conn.ping(None) {
+        Ok(_) => return 0,
+        Err(e) => return e.to_errno() as c_int,
+    }
+}
+
+/// Send a Ping frame on the specified path for keep-alive.
+/// The API is only applicable to multipath quic connections.
+#[no_mangle]
+pub extern "C" fn quic_conn_ping_path(
+    conn: &mut Connection,
+    local: &sockaddr,
+    local_len: socklen_t,
+    remote: &sockaddr,
+    remote_len: socklen_t,
+) -> c_int {
+    let addr = FourTuple {
+        local: sock_addr_from_c(local, local_len),
+        remote: sock_addr_from_c(remote, remote_len),
+    };
+    match conn.ping(Some(addr)) {
+        Ok(_) => return 0,
+        Err(e) => return e.to_errno() as c_int,
+    }
+}
+
 /// Add a new path on the client connection.
 #[no_mangle]
 pub extern "C" fn quic_conn_add_path(