diff --git a/Makefile b/Makefile
index d35afc79..223df2e7 100644
--- a/Makefile
+++ b/Makefile
@@ -68,12 +68,11 @@ install-frontend:
 
 # Install Python dependencies.
 install-python:
-	python3 -m venv env
-	. env/bin/activate; pip install --upgrade pip
-	. env/bin/activate; pip install -r requirements.txt
+	uv venv env
+	. env/bin/activate && uv pip install --upgrade pip && uv pip install -r requirements.txt
 
 # Fetch and build all i18n files.
-install-i18n: py-venv-check
+install-i18n:
 	python -m ambuda.scripts.fetch_i18n_files
 	# Force a build with `-f`. Transifex files have a `fuzzy` annotation, so if
 	# we build without this flag, then all of the files will be skipped with:
@@ -87,7 +86,7 @@ install-i18n: py-venv-check
 # Upgrade an existing setup.
 upgrade:
 	make install-frontend install-python
-	. env/bin/activate; make install-i18n
+	./activate.sh install-i18n
 	. env/bin/activate; alembic upgrade head
 	. env/bin/activate; python -m ambuda.seed.lookup
 
diff --git a/README.md b/README.md
index 1096a56e..47c22f33 100644
--- a/README.md
+++ b/README.md
@@ -15,20 +15,23 @@ database.
 Quickstart
 ----------
 
-(This setup process requires Docker. If you don't have Docker installed on your
-machine, you can install it [here][docker].)
+(This setup process requires Docker and UV. If you don't have Docker installed on your
+machine, you can install it [here][docker] and [here][uv].)
 
 To install and run Ambuda locally, please run the commands below:
 
 ```
 $ git clone https://github.com/ambuda-org/ambuda.git
 $ cd ambuda
+$ uv venv env
+$ source env/bin/activate && uv pip install --upgrade pip && uv pip install -r requirements.txt
 $ make devserver
 ```
 
 Then, navigate to `http://localhost:5000` in your web browser.
 
 [docker]: https://docs.docker.com/get-docker/
+[uv]: https://github.com/astral-sh/uv
 
 
 Documentation
diff --git a/activate.sh b/activate.sh
new file mode 100755
index 00000000..c5182571
--- /dev/null
+++ b/activate.sh
@@ -0,0 +1,9 @@
+#!/bin/bash
+set -euo pipefail
+
+# Activate the virtual environment.
+source env/bin/activate
+
+# "$@" expands to all arguments passed to the script
+make "$@"
+deactivate
diff --git a/requirements.txt b/requirements.txt
index ffb68c72..6a4bd747 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -4,7 +4,7 @@ babel==2.12.1
 backports-functools-lru-cache==1.6.4
 bcrypt==4.0.0
 black==22.12.0
-celery==5.2.7
+celery==5.4.0
 click==8.1.3
 conllu==4.5.2
 cryptography==38.0.1
@@ -23,19 +23,19 @@ google-api-core[grpc]==2.8.2
 google-auth==2.9.0
 google-cloud-vision==3.1.1
 googleapis-common-protos==1.56.3
-greenlet==1.1.2
+greenlet==3.1.1
 gunicorn==20.1.0
 indic-transliteration==2.3.31
 jinja2==3.1.2
-kombu==5.2.4
+kombu==5.4.2
 linkify-it-py==2.0.0
-lxml==4.9.1
+lxml==5.3.0
 mako==1.2.2
 markdown-it-py==2.1.0
 markupsafe==2.1.1
 mypy-extensions==0.4.3
 pillow==9.1.1
-pymupdf==1.20.2
+pymupdf==1.25.0
 pytest==7.2.2
 pytest-cov==4.0.0
 python-dateutil==2.8.2
@@ -46,7 +46,7 @@ redis==4.3.4
 regex==2022.6.2
 requests==2.27.1
 ruff==0.0.260
-sentry-sdk==1.6.0
+sentry-sdk==2.19.2
 sphinx-rtd-theme==1.0.0
 sphinx==5.0.2
 sphinxcontrib-applehelp==1.0.2
@@ -57,5 +57,5 @@ sphinxcontrib-qthelp==1.0.3
 sphinxcontrib-serializinghtml==1.1.5
 sqlalchemy==1.4.37
 werkzeug==2.1.2
-wtforms==3.0.1
-wtforms-sqlalchemy==0.3
+wtforms==3.2.1
+wtforms-sqlalchemy==0.4.2