diff --git a/packages/aws-cdk-lib/region-info/build-tools/fact-tables.ts b/packages/aws-cdk-lib/region-info/build-tools/fact-tables.ts
index 4e147d0ab3eff..9f88ddaa1fea6 100644
--- a/packages/aws-cdk-lib/region-info/build-tools/fact-tables.ts
+++ b/packages/aws-cdk-lib/region-info/build-tools/fact-tables.ts
@@ -78,6 +78,8 @@ enum Partition {
   UsGov = 'aws-us-gov',
   UsIso = 'aws-iso',
   UsIsoB = 'aws-iso-b',
+  UsIsoF = 'aws-iso-f',
+  EuIsoE = 'aws-iso-e',
 }
 
 interface Region { partition: Partition; domainSuffix: string }
@@ -88,6 +90,31 @@ export const PARTITION_MAP: { [region: string]: Region } = {
   'us-gov-': { partition: Partition.UsGov, domainSuffix: 'amazonaws.com' },
   'us-iso-': { partition: Partition.UsIso, domainSuffix: 'c2s.ic.gov' },
   'us-isob-': { partition: Partition.UsIsoB, domainSuffix: 'sc2s.sgov.gov' },
+  'us-isof-': { partition: Partition.UsIsoF, domainSuffix: 'csp.hci.ic.gov' },
+  'eu-isoe-': { partition: Partition.EuIsoE, domainSuffix: 'cloud.adc-e.uk' },
+};
+
+export const PARTITION_SAML_SIGN_ON_URL: Partial<Record<Partition, string>> = {
+  [Partition.Default]: 'https://signin.aws.amazon.com/saml',
+  [Partition.Cn]: 'https://signin.amazonaws.cn/saml',
+  [Partition.UsGov]: 'https://signin.amazonaws-us-gov.com/saml',
+  [Partition.UsIso]: 'https://signin.c2shome.ic.gov/saml',
+  [Partition.UsIsoB]: 'https://signin.sc2shome.sgov.gov/saml',
+};
+
+enum Runtime {
+  NODE_18 = 'nodejs18.x',
+  NODE_20 = 'nodejs20.x'
+}
+
+export const LATEST_NODE_RUNTIME_MAP: Record<Partition, string> = {
+  [Partition.Default]: Runtime.NODE_20,
+  [Partition.Cn]: Runtime.NODE_18,
+  [Partition.UsGov]: Runtime.NODE_18,
+  [Partition.UsIso]: Runtime.NODE_18,
+  [Partition.UsIsoB]: Runtime.NODE_18,
+  [Partition.UsIsoF]: Runtime.NODE_18,
+  [Partition.EuIsoE]: Runtime.NODE_18,
 };
 
 // https://docs.aws.amazon.com/elasticloadbalancing/latest/application/load-balancer-access-logs.html#access-logging-bucket-permissions
@@ -3693,19 +3720,3 @@ export const ADOT_LAMBDA_LAYER_ARNS: { [key: string]: any } = {
   PYTHON_SDK: ADOT_LAMBDA_LAYER_PYTHON_SDK_ARNS,
   GENERIC: ADOT_LAMBDA_LAYER_GENERIC_ARNS,
 };
-
-export const PARTITION_SAML_SIGN_ON_URL: Record<Partition, string> = {
-  [Partition.Default]: 'https://signin.aws.amazon.com/saml',
-  [Partition.Cn]: 'https://signin.amazonaws.cn/saml',
-  [Partition.UsGov]: 'https://signin.amazonaws-us-gov.com/saml',
-  [Partition.UsIso]: 'https://signin.c2shome.ic.gov/saml',
-  [Partition.UsIsoB]: 'https://signin.sc2shome.sgov.gov/saml',
-};
-
-export const LATEST_NODE_RUNTIME_MAP: Record<Partition, string> = {
-  [Partition.Default]: 'nodejs20.x',
-  [Partition.Cn]: 'nodejs18.x',
-  [Partition.UsGov]: 'nodejs18.x',
-  [Partition.UsIso]: 'nodejs18.x',
-  [Partition.UsIsoB]: 'nodejs18.x',
-};
diff --git a/packages/aws-cdk-lib/region-info/build-tools/generate-static-data.ts b/packages/aws-cdk-lib/region-info/build-tools/generate-static-data.ts
index 9adba22c9b92d..43f01925e6640 100644
--- a/packages/aws-cdk-lib/region-info/build-tools/generate-static-data.ts
+++ b/packages/aws-cdk-lib/region-info/build-tools/generate-static-data.ts
@@ -140,9 +140,11 @@ export async function main(): Promise<void> {
 
   await fs.writeFile(path.resolve(__dirname, '..', 'lib', 'built-ins.generated.ts'), lines.join('\n'));
 
-  function registerFact(region: string, name: string | string[], value: string) {
-    const factName = typeof name === 'string' ? name : `${name[0]}(${name.slice(1).map(s => JSON.stringify(s)).join(', ')})`;
-    lines.push(`    Fact.register({ region: ${JSON.stringify(region)}, name: FactName.${factName}, value: ${JSON.stringify(value)} });`);
+  function registerFact(region: string, name: string | string[], value?: string) {
+    if (value) {
+      const factName = typeof name === 'string' ? name : `${name[0]}(${name.slice(1).map(s => JSON.stringify(s)).join(', ')})`;
+      lines.push(`    Fact.register({ region: ${JSON.stringify(region)}, name: FactName.${factName}, value: ${JSON.stringify(value)} });`);
+    }
   }
 }
 
diff --git a/packages/aws-cdk-lib/region-info/lib/aws-entities.ts b/packages/aws-cdk-lib/region-info/lib/aws-entities.ts
index 614c04a4f427e..d291d46bc1d41 100644
--- a/packages/aws-cdk-lib/region-info/lib/aws-entities.ts
+++ b/packages/aws-cdk-lib/region-info/lib/aws-entities.ts
@@ -52,16 +52,21 @@ export const AWS_REGIONS_AND_RULES: readonly (string | symbol)[] = [
   RULE_CLASSIC_PARTITION_BECOMES_OPT_IN,
   'ap-east-1', // Asia Pacific (Hong Kong)
   'me-south-1', // Middle East (Bahrain)
-  'eu-south-1', // Europe (Milan)
   'af-south-1', // Africa (Cape Town)
+  'eu-south-1', // Europe (Milan)
   'us-iso-west-1', // US ISO West
-  'eu-south-2', // Europe (Spain)
   'ap-southeast-3', // Asia Pacific (Jakarta)
   'me-central-1', // Middle East (UAE)
-  'ap-south-2', // Asia Pacific (Hyderabad)
   'eu-central-2', // Europe (Zurich)
-  'il-central-1', // Israel (Tel Aviv)
+  'eu-south-2', // Europe (Spain)
+  'ap-south-2', // Asia Pacific (Hyderabad)
   'ap-southeast-4', // Asia Pacific (Melbourne)
+  'il-central-1', // Israel (Tel Aviv)
+  'ca-west-1', // Canada West (Calgary)
+  'ap-southeast-5', // Asia Pacific (Malaysia)
+  'ap-southeast-7', // Asia Pacific (Thailand)
+  'mx-central-1', // Mexico (Central)
+  'eu-isoe-west-1', // EU ISO-E West
 ];
 
 /**
@@ -128,6 +133,8 @@ const PARTITION_MAP: {readonly [region: string]: Region } = {
   'us-gov-': { partition: 'aws-us-gov', domainSuffix: 'amazonaws.com' },
   'us-iso-': { partition: 'aws-iso', domainSuffix: 'c2s.ic.gov' },
   'us-isob-': { partition: 'aws-iso-b', domainSuffix: 'sc2s.sgov.gov' },
+  'us-isof-': { partition: 'aws-iso-f', domainSuffix: 'csp.hci.ic.gov' },
+  'eu-isoe-': { partition: 'aws-iso-e', domainSuffix: 'cloud.adc-e.uk' },
 };
 
 export function partitionInformation(region: string): Region {