-
Notifications
You must be signed in to change notification settings - Fork 19
New issue
Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.
By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.
Already on GitHub? Sign in to your account
Improve distance estimation #130
Comments
Comparing equation 3 in the paper to the current Monte Carlo method and/or using this method for drawing the tree? |
Sorry if I was unclear - rather than correcting for false positive matches, it would be a correction for multiple substitutions occurring at the same site - this should not change small distances, but would increase larger distances (which are systematically underestimated), which might help separate within & between strain distances where Hamming distances are large. But at a simpler level, it might improve the phylogenies. |
It may be worth testing whether corrections to the pairwise distances could be employed as described in https://gitlab.pasteur.fr/GIPhy/JolyTree, as we are now observing core Hamming distances >0.1; as an initial test, it could be employed in the tree visualisation, but may even be helpful in resolving within strain/between strain distances.
The text was updated successfully, but these errors were encountered: