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Is your feature request related to a problem? Please describe.
We have suboptimal implementation of PP3 and BP4 VCEPs.
Describe the solution you'd like
Optimize the implementation:
Combine methods such as _is_splice_variant_is_inframe_indel, _is_missense_variant, _is_synonymous_variant, _is_intron_variant, _is_utr_variant. They all share same logic, so they can be combined in 1 supermethod with additional parameter(s).
Improve _affect_spliceAI method by providing one threshold for all spliceAI scores. This threshold is the "delta" score of spliceAI. Change it also in AutoBP7._spliceai_impact and AutoPS1PM5._affect_splicing.
Change the VCEPs as needed.
Update unit tests
Describe alternatives you've considered
N/A
Additional context
N/A
The text was updated successfully, but these errors were encountered:
Is your feature request related to a problem? Please describe.
We have suboptimal implementation of PP3 and BP4 VCEPs.
Describe the solution you'd like
Optimize the implementation:
_is_splice_variant
_is_inframe_indel
,_is_missense_variant
,_is_synonymous_variant
,_is_intron_variant
,_is_utr_variant
. They all share same logic, so they can be combined in 1 supermethod with additional parameter(s)._affect_spliceAI
method by providing one threshold for all spliceAI scores. This threshold is the "delta" score of spliceAI. Change it also inAutoBP7._spliceai_impact
andAutoPS1PM5._affect_splicing
.Describe alternatives you've considered
N/A
Additional context
N/A
The text was updated successfully, but these errors were encountered: