diff --git a/src/dxtbx/format/FormatCBFMiniPilatusSPring8_1MSN163.py b/src/dxtbx/format/FormatCBFMiniPilatusSPring8_1MSN163.py
new file mode 100644
index 000000000..549d7565f
--- /dev/null
+++ b/src/dxtbx/format/FormatCBFMiniPilatusSPring8_1MSN163.py
@@ -0,0 +1,51 @@
+from __future__ import annotations
+
+import dxtbx.flumpy as flumpy
+from dxtbx.format.FormatCBFMiniPilatus import FormatCBFMiniPilatus
+from dxtbx.model import Detector
+
+
+class FormatCBFMiniPilatusSPring8_1MSN163(FormatCBFMiniPilatus):
+    """A class for reading mini CBF format Pilatus images for 6M SN 125, normally
+    at Spring8 BL41XU"""
+
+    @staticmethod
+    def understand(image_file):
+        """Check to see if this looks like an Pilatus mini CBF format image,
+        i.e. we can make sense of it."""
+
+        header = FormatCBFMiniPilatus.get_cbf_header(image_file)
+
+        for record in header.split("\n"):
+            if (
+                "# Detector" in record
+                and "PILATUS" in record
+                and "S/N 10-0163" in header
+            ):
+                return True
+
+        return False
+
+    def __init__(self, image_file, **kwargs):
+        self._inverted = False
+        super().__init__(image_file, **kwargs)
+
+    def _detector(self) -> Detector:
+        # Do inversion of header dictionary here... is intialised in
+        # _start so we have to intercept afterwards
+        if not self._inverted:
+            self._inverted = True
+            (
+                self._cif_header_dictionary["X-Binary-Size-Fastest-Dimension"],
+                self._cif_header_dictionary["X-Binary-Size-Second-Dimension"],
+            ) = (
+                self._cif_header_dictionary["X-Binary-Size-Second-Dimension"],
+                self._cif_header_dictionary["X-Binary-Size-Fastest-Dimension"],
+            )
+        return super()._detector()
+
+    def get_raw_data(self):
+        data = super().get_raw_data()
+        # Transpose the data
+        ndata = flumpy.from_numpy(flumpy.to_numpy(data).transpose().copy())
+        return ndata