diff --git a/include/dmlc/build_config_default.h b/include/dmlc/build_config_default.h
index 210e0550a..20e603d4e 100644
--- a/include/dmlc/build_config_default.h
+++ b/include/dmlc/build_config_default.h
@@ -21,7 +21,8 @@
      && !defined(__sun) && !defined(__SVR4)\
      && !(defined __MINGW64__) && !(defined __ANDROID__))\
      && !defined(__CYGWIN__) && !defined(__EMSCRIPTEN__)\
-     && !defined(__RISCV__) && !defined(__hexagon__)
+     && !defined(__RISCV__) && !defined(__hexagon__)\
+     && !defined(__QNX__)
   #if !defined(DMLC_LOG_STACK_TRACE)
     #define DMLC_LOG_STACK_TRACE 1
     #define DMLC_EXECINFO_H <execinfo.h>
diff --git a/include/dmlc/endian.h b/include/dmlc/endian.h
index c72739e76..868709b00 100644
--- a/include/dmlc/endian.h
+++ b/include/dmlc/endian.h
@@ -21,6 +21,9 @@
   #elif defined(__FreeBSD__) || defined(__OpenBSD__)
     #include <sys/endian.h>
     #define DMLC_LITTLE_ENDIAN (_BYTE_ORDER == _LITTLE_ENDIAN)
+  #elif defined(__QNX__)
+    #include <sys/param.h>
+    #define DMLC_LITTLE_ENDIAN (BYTE_ORDER == LITTLE_ENDIAN)
   #elif defined(__EMSCRIPTEN__) || defined(__hexagon__)
     #define DMLC_LITTLE_ENDIAN 1
   #elif defined(__sun) || defined(sun)