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inhibitors_from_chembl.csv
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inhibitors_from_chembl.csv
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"Molecule ChEMBL ID";"Molecule Name";"Molecule Max Phase";"Molecular Weight";"#RO5 Violations";"AlogP";"Compound Key";"Smiles";"Standard Type";"Standard Relation";"Standard Value";"Standard Units";"pChEMBL Value";"Data Validity Comment";"Comment";"Uo Units";"Ligand Efficiency BEI";"Ligand Efficiency LE";"Ligand Efficiency LLE";"Ligand Efficiency SEI";"Potential Duplicate";"Assay ChEMBL ID";"Assay Description";"Assay Type";"BAO Format ID";"BAO Label";"Assay Organism";"Assay Tissue ChEMBL ID";"Assay Tissue Name";"Assay Cell Type";"Assay Subcellular Fraction";"Assay Parameters";"Assay Variant Accession";"Assay Variant Mutation";"Target ChEMBL ID";"Target Name";"Target Organism";"Target Type";"Document ChEMBL ID";"Source ID";"Source Description";"Document Journal";"Document Year";"Cell ChEMBL ID";"Properties"
"CHEMBL1444844";"";"0";"429.56";"0";"4.60";"76";"CCN(CCCCOC(=O)c1ccc(OC)c(OC)c1)[C@@H](C)Cc1ccc(OC)cc1";"Inhibition";"'='";"45.2";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4043389";"Inhibition of NorA in Staphylococcus aureus SA1199B harboring GrlA A116E mutant assessed as inhibition of ethidium bromide efflux at 50 uM measured after 5 mins by fluorometric method relative to control";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4043064";"1";"Scientific Literature";"J Med Chem";"2017";"None";""
"CHEMBL1651022";"";"0";"343.40";"0";"3.67";"60";"CN1CC[C@H](c2ccc(F)cc2)[C@@H](COc2ccc3c(c2)OCO3)C1";"Inhibition";"'='";"85.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL4170063";"";"0";"434.58";"1";"5.95";"3c";"CCCOc1ccc(-c2cc(OCCN3CCCCCC3)c3cc(OC)ccc3n2)cc1";"Inhibition";"'='";"92.2";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL481947";"";"0";"225.32";"0";"3.91";"6a";"c1ccc(C2=Nc3ccccc3SC2)cc1";"Inhibition";"'='";"0.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1015715";"Inhibition of NorA pump-mediated ethidium bromide efflux in Staphylococcus aureus K1199B at 50 uM by fluorimetric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1155078";"1";"Scientific Literature";"J. Med. Chem.";"2008";"None";""
"CHEMBL1651194";"";"0";"496.63";"0";"4.25";"111";"CCOC(=O)c1cn(C2CC2)c2c(C)c(N3CCC4=C(C3)/C(=N/OC)C(C)CS4)c(N)cc2c1=O";"Inhibition";"'='";"21.4";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL94739";"FEMOXETINE";"0";"311.43";"0";"3.81";"58";"COc1ccc(OC[C@H]2CN(C)CC[C@@H]2c2ccccc2)cc1";"Inhibition";"'='";"47.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL3774806";"";"0";"406.53";"0";"4.95";"76";"Cc1c(C(=O)O)c2cc(OCCCN3CCCCC3)ccc2n1Cc1ccccc1";"Inhibition";"'='";"0.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL482125";"";"0";"293.31";"0";"4.93";"7a";"FC(F)(F)c1ccc2c(c1)N=C(c1ccccc1)CS2";"Inhibition";"'='";"8.4";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL1015715";"Inhibition of NorA pump-mediated ethidium bromide efflux in Staphylococcus aureus K1199B at 50 uM by fluorimetric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1155078";"1";"Scientific Literature";"J. Med. Chem.";"2008";"None";""
"CHEMBL3775841";"";"0";"366.46";"0";"3.90";"6c";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCCN)cc12";"Inhibition";"'='";"100.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3879153";"Inhibition of Staphylococcus aureus 1199B NorA assessed as inhibition of ethidium bromide efflux at 50 uM measured after 5 mins by fluorometric method relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3877305";"1";"Scientific Literature";"J Med Chem";"2017";"None";""
"CHEMBL3922059";"";"0";"341.37";"0";"1.55";"5";"COc1cc(CNCCO)ccc1Oc1nnnn1-c1ccccc1";"Inhibition";"'<'";"10.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3879153";"Inhibition of Staphylococcus aureus 1199B NorA assessed as inhibition of ethidium bromide efflux at 50 uM measured after 5 mins by fluorometric method relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3877305";"1";"Scientific Literature";"J Med Chem";"2017";"None";""
"CHEMBL3774548";"";"0";"464.61";"1";"5.44";"53";"CCOC(=O)c1c(C)n(Cc2ccccc2OC)c2ccc(OCCCN3CCCCC3)cc12";"Inhibition";"'='";"87.9";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL3775611";"";"0";"344.46";"0";"3.91";"47";"CCOC(=O)c1c(C)[nH]c2ccc(OCCCN3CCCCC3)cc12";"Inhibition";"'='";"34.2";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL2385681";"";"0";"400.95";"1";"5.02";"3i";"CCCOc1ccc(-c2cc(OCCCN(C)C)c3ccccc3n2)cc1.Cl";"Inhibition";"'='";"90.6";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2390114";"Inhibition of NorA in Staphylococcus aureus 1199B harboring grlA A116E mutant assessed as inhibition of ethidium bromide efflux at 50 uM measured for 5 mins by fluorometric analysis relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL3775726";"";"0";"464.61";"1";"5.44";"55";"CCOC(=O)c1c(C)n(Cc2ccc(OC)cc2)c2ccc(OCCCN3CCCCC3)cc12";"Inhibition";"'='";"77.7";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL3948087";"";"0";"504.60";"2";"5.88";"16";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCCNCc3ccc(F)c(OC)c3)cc12";"Inhibition";"'='";"67.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3879153";"Inhibition of Staphylococcus aureus 1199B NorA assessed as inhibition of ethidium bromide efflux at 50 uM measured after 5 mins by fluorometric method relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3877305";"1";"Scientific Literature";"J Med Chem";"2017";"None";""
"CHEMBL2385672";"";"0";"370.45";"1";"5.66";"3j";"CCCOc1ccc(-c2cc(OCc3ccccn3)c3ccccc3n2)cc1";"Inhibition";"'='";"19.6";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2390114";"Inhibition of NorA in Staphylococcus aureus 1199B harboring grlA A116E mutant assessed as inhibition of ethidium bromide efflux at 50 uM measured for 5 mins by fluorometric analysis relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL2385677";"";"0";"400.95";"1";"5.02";"3e";"CCCOc1ccc(-c2cc(OCC(C)N(C)C)c3ccccc3n2)cc1.Cl";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL2390107";"Inhibition of NorA in Staphylococcus aureus ATCC 25923 assessed as reduction of ciprofloxacin MIC at 0.78 to 100 ug/mL";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL1075";"MORICIZINE";"4";"427.53";"0";"4.11";"72";"CCOC(=O)Nc1ccc2c(c1)N(C(=O)CCN1CCOCC1)c1ccccc1S2";"Inhibition";"'='";"23.7";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4043389";"Inhibition of NorA in Staphylococcus aureus SA1199B harboring GrlA A116E mutant assessed as inhibition of ethidium bromide efflux at 50 uM measured after 5 mins by fluorometric method relative to control";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4043064";"1";"Scientific Literature";"J Med Chem";"2017";"None";""
"CHEMBL4170063";"";"0";"434.58";"1";"5.95";"3c";"CCCOc1ccc(-c2cc(OCCN3CCCCCC3)c3cc(OC)ccc3n2)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4151517";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as synergistic potentiation of ciprofloxacin-induced antimicrobial activity at 0.78 to 100 ug/ml by microdilution method based Checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4168315";"";"0";"511.67";"2";"5.90";"4f";"CCCOc1ccc(-c2cc(OCCN3CCN(Cc4ccccc4)CC3)c3ccc(OC)cc3n2)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4151517";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as synergistic potentiation of ciprofloxacin-induced antimicrobial activity at 0.78 to 100 ug/ml by microdilution method based Checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL2385691";"";"0";"434.62";"1";"6.97";"3u";"CCCCN(CCCC)CCOc1cc(-c2ccc(OCCC)cc2)nc2ccccc12";"Inhibition";"'='";"88.6";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2390114";"Inhibition of NorA in Staphylococcus aureus 1199B harboring grlA A116E mutant assessed as inhibition of ethidium bromide efflux at 50 uM measured for 5 mins by fluorometric analysis relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL2158996";"";"0";"338.36";"0";"3.61";"7";"C=CCOc1ccccc1C(=O)/C=C/c1ccc(OCC(=O)O)cc1";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL2162039";"Inhibition of norA in Staphylococcus aureus ATCC 29213 overexpressing norA assessed as fold reduction in ciprofloxacin MIC by checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL708";"ZIPRASIDONE";"4";"412.95";"0";"3.81";"10";"O=C1Cc2cc(CCN3CCN(c4nsc5ccccc45)CC3)c(Cl)cc2N1";"Inhibition";"'='";"86.6";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2049765";"Inhibition of norA-mediated ethidium bromide efflux in Staphylococcus aureus SA-1199B harboring grlA A116E mutant at 50 uM after 5 mins by fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2046272";"1";"Scientific Literature";"ACS Med. Chem. Lett.";"2012";"None";""
"CHEMBL2158997";"";"0";"313.37";"0";"3.66";"8";"CN(C)CCOc1ccc(C(=O)/C=C/c2ccccc2F)cc1";"Inhibition";"'='";"48.5";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2162041";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 5 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL358518";"";"0";"284.31";"0";"3.31";"5";"COc1cc(O)cc(C)c1/C=C/C(=O)c1ccc(O)cc1";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL2162038";"Inhibition of norA in Staphylococcus aureus SA-1199B overexpressing norA assessed as fold reduction in ciprofloxacin MIC by checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL3920269";"";"0";"524.63";"1";"4.71";"15";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCCNCc3nnnn3-c3ccccc3)cc12";"Inhibition";"'='";"22.8";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3879153";"Inhibition of Staphylococcus aureus 1199B NorA assessed as inhibition of ethidium bromide efflux at 50 uM measured after 5 mins by fluorometric method relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3877305";"1";"Scientific Literature";"J Med Chem";"2017";"None";""
"CHEMBL3775416";"";"0";"456.59";"1";"5.73";"6a";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCCNCc3ccccc3)cc12";"Inhibition";"'='";"45.5";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3879153";"Inhibition of Staphylococcus aureus 1199B NorA assessed as inhibition of ethidium bromide efflux at 50 uM measured after 5 mins by fluorometric method relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3877305";"1";"Scientific Literature";"J Med Chem";"2017";"None";""
"CHEMBL1484";"NICARDIPINE";"4";"479.53";"0";"3.68";"77";"COC(=O)C1=C(C)NC(C)=C(C(=O)OCCN(C)Cc2ccccc2)C1c1cccc([N+](=O)[O-])c1";"Inhibition";"'='";"77.1";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4043389";"Inhibition of NorA in Staphylococcus aureus SA1199B harboring GrlA A116E mutant assessed as inhibition of ethidium bromide efflux at 50 uM measured after 5 mins by fluorometric method relative to control";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4043064";"1";"Scientific Literature";"J Med Chem";"2017";"None";""
"CHEMBL3938230";"";"0";"587.74";"2";"6.17";"11";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCCN3CCN(CCCOc4ccc(F)cc4)CC3)cc12";"Inhibition";"'='";"53.7";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3879153";"Inhibition of Staphylococcus aureus 1199B NorA assessed as inhibition of ethidium bromide efflux at 50 uM measured after 5 mins by fluorometric method relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3877305";"1";"Scientific Literature";"J Med Chem";"2017";"None";""
"CHEMBL772";"RESERPINE";"4";"608.69";"1";"4.17";"Reserpine";"COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC";"Inhibition";"'='";"84.8";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL1651014";"";"0";"428.44";"1";"5.55";"49";"N#Cc1c(C(F)(F)F)cc(Cc2ccccc2)nc1SCc1ccc(C(=O)O)cc1";"Inhibition";"'='";"41.8";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL4161736";"";"0";"420.55";"1";"5.56";"4b";"CCCOc1ccc(-c2cc(OCCN3CCCCC3)c3ccc(OC)cc3n2)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4151517";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as synergistic potentiation of ciprofloxacin-induced antimicrobial activity at 0.78 to 100 ug/ml by microdilution method based Checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4164750";"";"0";"491.68";"1";"5.89";"11d";"CCCOc1ccc(-c2cc(OCCN3CCCCC3)c3cc(OCCCN(C)C)ccc3n2)cc1";"Inhibition";"'='";"92.5";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4155967";"Inhibition of Staphylococcus aureus SA-1199B NorA assessed as reduction in EtBr efflux at 50 uM measured over 5 mins by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4152305";"1";"Scientific Literature";"Eur J Med Chem";"2018";"None";""
"CHEMBL458207";"";"0";"502.50";"2";"5.05";"14";"CC1COc2c(NCc3ccc(NC(=O)Nc4ccccc4)cc3)c(F)cc3c(=O)c(C(=O)O)cn1c23";"Inhibition";"'='";"96.4";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1017715";"Inhibition of NorA efflux pump in Staphylococcus aureus K2361 assessed as reduction of ethidium bromide efflux at 10 uM for 5 mins";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1154468";"1";"Scientific Literature";"Eur. J. Med. Chem.";"2008";"None";""
"CHEMBL4177330";"";"0";"510.63";"2";"6.77";"7";"CCCOc1ccc(-c2cc(OCCN3CCCCC3)c3cc(OC(=O)c4ccccc4)ccc3n2)cc1";"Inhibition";"'='";"76.3";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4155967";"Inhibition of Staphylococcus aureus SA-1199B NorA assessed as reduction in EtBr efflux at 50 uM measured over 5 mins by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4152305";"1";"Scientific Literature";"Eur J Med Chem";"2018";"None";""
"CHEMBL480166";"";"0";"315.39";"0";"3.94";"71";"COc1cc(C2=Nc3ccccc3SC2)cc(OC)c1OC";"Inhibition";"'='";"23.6";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1630217";"";"0";"622.08";"2";"6.74";"SS14-M";"COc1ccc2c(Cc3cccc(-c4cc5cc([N+](=O)[O-])ccc5[nH]4)c3)c3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2.[Cl-]";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL1638737";"Inhibition of NorA in Staphylococcus aureus K2378 overexpressing NorA assessed as increase in ethidium bromide uptake at 3 uM by fluorescence assay in presence of INF55";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1629702";"1";"Scientific Literature";"Antimicrob. Agents Chemother.";"2010";"None";""
"CHEMBL1651175";"";"0";"353.42";"0";"4.01";"23f";"CCCOc1ccc(-c2cc(=O)c3cc(OC)c(OC)cc3n2C)cc1";"Inhibition";"'='";"0.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1817147";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as inhibition of ethidium bromide efflux at 50 uM by fluorimetry";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1811797";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651178";"";"0";"283.28";"0";"2.32";"26c";"Cn1c(-c2ccc(O)cc2)cc(=O)c2cc(O)c(O)cc21";"Inhibition";"'='";"0.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1817147";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as inhibition of ethidium bromide efflux at 50 uM by fluorimetry";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1811797";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651162";"";"0";"378.52";"0";"4.80";"24f";"CCCOc1ccc(-c2cc(=O)c3ccccc3n2CCN(CC)CC)cc1";"Inhibition";"'='";"57.3";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1817147";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as inhibition of ethidium bromide efflux at 50 uM by fluorimetry";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1811797";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651163";"";"0";"390.53";"0";"4.94";"25f";"CCCOc1ccc(-c2cc(=O)c3ccccc3n2CCN2CCCCC2)cc1";"Inhibition";"'='";"75.1";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1817147";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as inhibition of ethidium bromide efflux at 50 uM by fluorimetry";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1811797";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL3741903";"";"0";"560.70";"1";"4.97";"C18";"CCCCC(=O)NC1(CC(=O)NNc2ccccc2)CCN(C(=O)/C=C/C(=C/c2ccc3c(c2)OCO3)CC)CC1";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL4480154";"Inhibition of NorA efflux pump overexpressed in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux measured over 30 mins by fluorescence analysis";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4477264";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2016";"None";""
"CHEMBL841";"LOPERAMIDE";"4";"477.05";"1";"5.09";"LOPERAMIDE";"CN(C)C(=O)C(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1";"Inhibition";"'='";"77.7";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2049765";"Inhibition of norA-mediated ethidium bromide efflux in Staphylococcus aureus SA-1199B harboring grlA A116E mutant at 50 uM after 5 mins by fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2046272";"1";"Scientific Literature";"ACS Med. Chem. Lett.";"2012";"None";""
"CHEMBL2385692";"";"0";"440.59";"1";"6.59";"3v";"CCCOc1ccc(-c2cc(OCCN(CC)Cc3ccccc3)c3ccccc3n2)cc1";"Inhibition";"'='";"72.5";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2390114";"Inhibition of NorA in Staphylococcus aureus 1199B harboring grlA A116E mutant assessed as inhibition of ethidium bromide efflux at 50 uM measured for 5 mins by fluorometric analysis relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL144721";"";"0";"298.34";"0";"3.61";"15";"COc1ccc(/C=C/C(=O)c2ccccc2OC)c(OC)c1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL2162181";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml after 150 to 160 secs by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL1651185";"";"0";"468.58";"0";"3.77";"102";"CCOC(=O)c1cn(C2CC2)c2cc(N3CCC4=C(C3)/C(=N/O)C(C)CS4)c(N)cc2c1=O";"Inhibition";"'='";"91.2";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651174";"";"0";"311.34";"0";"2.93";"89";"COc1cc2c(=O)cc(-c3ccc(O)cc3)n(C)c2cc1OC";"Inhibition";"'='";"0.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651001";"";"0";"461.52";"0";"4.59";"31, specs codeAM-807/42946590";"N#Cc1c(-c2ccc(F)cc2)cc(-c2ccccc2)nc1SCC(=O)N1CCC[C@@H]1C(=O)O";"Inhibition";"'='";"36.3";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651009";"";"0";"353.40";"0";"3.93";"44";"Cc1ccc(S(=O)(=O)Nc2ccc3[nH]c(-c4ccco4)nc3c2)cc1";"Inhibition";"'='";"67.5";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651010";"";"0";"333.43";"0";"4.09";"45";"OC(CNCc1cccc(OCc2ccccc2)c1)c1ccccc1";"Inhibition";"'='";"92.4";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL6966";"VERAPAMIL";"4";"454.61";"1";"5.09";"Verapamil";"COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL2162198";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL1642586";"";"0";"724.67";"3";"4.72";"NP";"C[C@@H]1O[C@@H](Oc2c(-c3ccc(O)cc3)oc3cc(O)cc(O)c3c2=O)[C@H](OC(=O)/C=C/c2ccc(O)cc2)[C@H](O)[C@H]1OC(=O)/C=C/c1ccc(O)cc1";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL2162198";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL4455615";"";"0";"387.91";"0";"4.52";"10";"COC(=O)CC1(NC(=O)/C=C/C2=C(Cl)c3ccccc3CC2)CCCCC1";"Inhibition";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL4311538";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM measured after 5 mins by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4308903";"1";"Scientific Literature";"Bioorg Med Chem";"2019";"None";""
"CHEMBL148216";"";"0";"358.39";"0";"3.63";"13";"COc1cc(/C=C/C(=O)c2ccc(OC)c(OC)c2OC)cc(OC)c1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL2162181";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml after 150 to 160 secs by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL148216";"";"0";"358.39";"0";"3.63";"13";"COc1cc(/C=C/C(=O)c2ccc(OC)c(OC)c2OC)cc(OC)c1";"Inhibition";"";"";"";"";"";"tde";"";"";"";"";"";"False";"CHEMBL2162184";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL422481";"";"0";"284.31";"0";"3.31";"6";"COc1ccc(OC)c(/C=C/C(=O)c2ccc(O)cc2)c1";"Inhibition";"";"";"";"";"";"tde";"";"";"";"";"";"False";"CHEMBL2162184";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL4171147";"";"0";"558.68";"2";"6.16";"7d";"CCCOc1ccc(-c2cc(OCCN3CCc4cc(OC)c(OC)cc4C3)c3cc(OC)c(OC)cc3n2)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4151517";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as synergistic potentiation of ciprofloxacin-induced antimicrobial activity at 0.78 to 100 ug/ml by microdilution method based Checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL1651007";"";"0";"363.44";"0";"4.13";"42";"Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)ncn3-c2ccccc2)cc1";"Inhibition";"'='";"0.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL2385680";"";"0";"406.57";"1";"6.19";"3h";"CCCOc1ccc(-c2cc(OCCN(C(C)C)C(C)C)c3ccccc3n2)cc1";"Inhibition";"'='";"88.2";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2390114";"Inhibition of NorA in Staphylococcus aureus 1199B harboring grlA A116E mutant assessed as inhibition of ethidium bromide efflux at 50 uM measured for 5 mins by fluorometric analysis relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL3775693";"";"0";"382.46";"0";"2.87";"42";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCC(N)CO)cc12";"Inhibition";"'='";"100.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL3775207";"";"0";"448.61";"1";"5.74";"50";"CCOC(=O)c1c(C)n(Cc2ccccc2C)c2ccc(OCCCN3CCCCC3)cc12";"Inhibition";"'='";"54.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL3774886";"";"0";"448.61";"1";"5.74";"51";"CCOC(=O)c1c(C)n(Cc2cccc(C)c2)c2ccc(OCCCN3CCCCC3)cc12";"Inhibition";"'='";"70.9";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL3774527";"";"0";"435.57";"0";"3.80";"24";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCN3CCN(C)CC3)cc12";"Inhibition";"'='";"99.7";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL1509012";"";"0";"265.31";"0";"3.21";"22d";"COc1ccc(-c2cc(=O)c3ccccc3n2C)cc1";"Inhibition";"'='";"0.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1817147";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as inhibition of ethidium bromide efflux at 50 uM by fluorimetry";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1811797";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651171";"";"0";"322.41";"0";"3.15";"22h";"CN(C)CCOc1ccc(-c2cc(=O)c3ccccc3n2C)cc1";"Inhibition";"'='";"4.4";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1817147";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as inhibition of ethidium bromide efflux at 50 uM by fluorimetry";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1811797";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL772";"RESERPINE";"4";"608.69";"1";"4.17";"Reserpine";"COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC";"Inhibition";"'='";"85.1";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL2162179";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 20 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL3219951";"";"0";"436.53";"0";"0.84";"18";"CCOC(=O)C1(C)C(=O)c2cc(N)c(N3CCN(C)CC3)cc2N(C2CC2)S1(=O)=O";"Inhibition";"'='";"25.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3226388";"Inhibition of NorA efflux pump in Staphylococcus aureus SA-1199B assessed as inhibition of EtBr efflux at 50 uM";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3217728";"1";"Scientific Literature";"MedChemComm";"2012";"None";""
"CHEMBL358518";"";"0";"284.31";"0";"3.31";"5";"COc1cc(O)cc(C)c1/C=C/C(=O)c1ccc(O)cc1";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL2162039";"Inhibition of norA in Staphylococcus aureus ATCC 29213 overexpressing norA assessed as fold reduction in ciprofloxacin MIC by checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL3956740";"";"0";"660.77";"3";"6.90";"14";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCCCNCc3ccc(Oc4nnnn4-c4ccccc4)c(OC)c3)cc12";"Inhibition";"'='";"100.8";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3879153";"Inhibition of Staphylococcus aureus 1199B NorA assessed as inhibition of ethidium bromide efflux at 50 uM measured after 5 mins by fluorometric method relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3877305";"1";"Scientific Literature";"J Med Chem";"2017";"None";""
"CHEMBL3775507";"";"0";"382.46";"0";"2.87";"2";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCC(O)CN)cc12";"Inhibition";"'='";"100.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3879153";"Inhibition of Staphylococcus aureus 1199B NorA assessed as inhibition of ethidium bromide efflux at 50 uM measured after 5 mins by fluorometric method relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3877305";"1";"Scientific Literature";"J Med Chem";"2017";"None";""
"CHEMBL118";"CELECOXIB";"4";"381.38";"0";"3.51";"Celecoxib";"Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1";"Inhibition";"'='";"64.5";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2051680";"Inhibition of norA-mediated EtBr efflux in Staphylococcus aureus SA1199B overexpressing norA and expressing A116E GrlA mutation at 50 uM by fluorometry";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2046274";"1";"Scientific Literature";"J. Med. Chem.";"2012";"None";""
"CHEMBL474759";"";"0";"313.40";"0";"3.78";"SK-20";"CCC(/C=C/C(=O)N1CCCCC1)=C\c1ccc2c(c1)OCO2";"Inhibition";"'='";"68.85";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4311539";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM measured over 5 mins interval for 30 mins by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4308903";"1";"Scientific Literature";"Bioorg Med Chem";"2019";"None";""
"CHEMBL1630218";"";"0";"622.08";"2";"6.74";"SS14-P";"COc1ccc2c(Cc3ccc(-c4cc5cc([N+](=O)[O-])ccc5[nH]4)cc3)c3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2.[Cl-]";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL1638735";"Inhibition of NorA in Staphylococcus aureus K2378 overexpressing NorA assessed as ethidium bromide uptake at 3 uM by fluorescence assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1629702";"1";"Scientific Literature";"Antimicrob. Agents Chemother.";"2010";"None";""
"CHEMBL2159001";"";"0";"320.39";"0";"3.39";"17";"CN(C)CCOc1ccc(C(=O)/C=C/c2ccc(C#N)cc2)cc1";"Inhibition";"";"";"";"";"";"tde";"";"";"";"";"";"False";"CHEMBL2162184";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL2159002";"";"0";"313.37";"0";"3.66";"18";"CN(C)CCOc1ccc(C(=O)/C=C/c2cccc(F)c2)cc1";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL2162198";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL1630218";"";"0";"622.08";"2";"6.74";"SS14-P";"COc1ccc2c(Cc3ccc(-c4cc5cc([N+](=O)[O-])ccc5[nH]4)cc3)c3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2.[Cl-]";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL1638734";"Inhibition of NorA in Staphylococcus aureus 8325-4 assessed as ethidium bromide uptake at 3 uM by fluorescence assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1629702";"1";"Scientific Literature";"Antimicrob. Agents Chemother.";"2010";"None";""
"CHEMBL141664";"";"0";"324.38";"0";"4.16";"14";"C=CCOc1ccc(C(=O)/C=C/c2cccc(OC)c2OC)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL2162181";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml after 150 to 160 secs by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL1650993";"";"0";"345.44";"0";"4.90";"25, specs codeAO-548/43242435";"C[C@H](O)c1cccc(NC(=O)CC(c2ccccc2)c2ccccc2)c1";"Inhibition";"'='";"31.4";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL490";"PAROXETINE";"4";"329.37";"0";"3.33";"Paroxetine";"Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1";"Inhibition";"'='";"73.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2390114";"Inhibition of NorA in Staphylococcus aureus 1199B harboring grlA A116E mutant assessed as inhibition of ethidium bromide efflux at 50 uM measured for 5 mins by fluorometric analysis relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL2048632";"";"0";"452.88";"0";"4.88";"3g";"O=[N+]([O-])c1ccc(-n2nc(-c3ccc(Cl)cc3)c3c2-c2ccccc2S(=O)(=O)N3)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL2051687";"Inhibition of norA overexpressed in Staphylococcus aureus SA1199B coexpressing A116E GrlA mutation assessed as potentiation of ciprofloxacin MIC by checkerboard assay";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2046274";"1";"Scientific Literature";"J. Med. Chem.";"2012";"None";""
"CHEMBL248779";"";"0";"350.42";"0";"3.56";"2";"COc1ccc(/C=C/C(=O)NCCc2c[nH]c3ccccc23)cc1OC";"Inhibition";"'='";"84.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL2385689";"";"0";"405.54";"0";"4.32";"3r";"CCCOc1ccc(-c2cc(OCCN3CCN(C)CC3)c3ccccc3n2)cc1";"Inhibition";"'='";"91.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2390114";"Inhibition of NorA in Staphylococcus aureus 1199B harboring grlA A116E mutant assessed as inhibition of ethidium bromide efflux at 50 uM measured for 5 mins by fluorometric analysis relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL2158993";"";"0";"385.46";"0";"3.55";"20";"COc1ccc(C(=O)/C=C/c2cccc(OCCN(C)C)c2)c(OC)c1OC";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL2162198";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL1651180";"";"0";"378.52";"1";"5.41";"28f";"CCCOc1ccc(-c2cc(OCCN(CC)CC)c3ccccc3n2)cc1";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL1817275";"Inhibition of wild-type norA expressing Staphylococcus aureus 1199 assessed as reduction in ciprofloxacin MIC";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1811797";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1542151";"";"0";"349.75";"0";"3.62";"53";"O=C1NC(=O)/C(=C/c2ccc(-c3cc(C(=O)O)ccc3Cl)o2)S1";"Inhibition";"'='";"15.5";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL2048633";"";"0";"500.99";"1";"4.35";"3i";"CS(=O)(=O)Nc1ccc(-n2nc(-c3ccc(Cl)cc3)c3c2-c2ccccc2S(=O)(=O)N3)cc1";"Inhibition";"'='";"19.2";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2051680";"Inhibition of norA-mediated EtBr efflux in Staphylococcus aureus SA1199B overexpressing norA and expressing A116E GrlA mutation at 50 uM by fluorometry";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2046274";"1";"Scientific Literature";"J. Med. Chem.";"2012";"None";""
"CHEMBL490";"PAROXETINE";"4";"329.37";"0";"3.33";"paroxetine";"Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1";"Inhibition";"'='";"89.7";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2051680";"Inhibition of norA-mediated EtBr efflux in Staphylococcus aureus SA1199B overexpressing norA and expressing A116E GrlA mutation at 50 uM by fluorometry";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2046274";"1";"Scientific Literature";"J. Med. Chem.";"2012";"None";""
"CHEMBL772";"RESERPINE";"4";"608.69";"1";"4.17";"reserpine";"COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL1817275";"Inhibition of wild-type norA expressing Staphylococcus aureus 1199 assessed as reduction in ciprofloxacin MIC";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1811797";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL2158999";"";"0";"338.45";"0";"3.59";"10";"CN(C)CCOc1ccc(C(=O)/C=C/c2ccc(N(C)C)cc2)cc1";"Inhibition";"'='";"97.4";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2162042";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 10 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL422481";"";"0";"284.31";"0";"3.31";"6";"COc1ccc(OC)c(/C=C/C(=O)c2ccc(O)cc2)c1";"Inhibition";"'='";"56.6";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2162041";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 5 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL422481";"";"0";"284.31";"0";"3.31";"6";"COc1ccc(OC)c(/C=C/C(=O)c2ccc(O)cc2)c1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL2162181";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml after 150 to 160 secs by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL4563966";"";"0";"345.83";"0";"3.30";"6";"COC(=O)[C@@H]1CCCN1C(=O)/C=C/C1=C(Cl)c2ccccc2CC1";"Inhibition";"'='";"80.33";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4311538";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM measured after 5 mins by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4308903";"1";"Scientific Literature";"Bioorg Med Chem";"2019";"None";""
"CHEMBL2385690";"";"0";"481.64";"1";"5.89";"3s";"CCCOc1ccc(-c2cc(OCCN3CCN(Cc4ccccc4)CC3)c3ccccc3n2)cc1";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL2390107";"Inhibition of NorA in Staphylococcus aureus ATCC 25923 assessed as reduction of ciprofloxacin MIC at 0.78 to 100 ug/mL";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL1651169";"";"0";"362.47";"0";"4.07";"22j";"Cn1c(-c2ccc(OCCN3CCCCC3)cc2)cc(=O)c2ccccc21";"Inhibition";"'='";"19.8";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1817147";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as inhibition of ethidium bromide efflux at 50 uM by fluorimetry";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1811797";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL4169284";"";"0";"450.58";"1";"5.57";"8b";"CCCOc1ccc(-c2cc(OCCN3CCCCC3)c3cc(OC)cc(OC)c3n2)cc1";"Inhibition";"'='";"93.8";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL2385669";"";"0";"349.47";"1";"6.12";"3a";"CCCOc1ccc(-c2cc(OCCC(C)C)c3ccccc3n2)cc1";"Inhibition";"'='";"33.2";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2390114";"Inhibition of NorA in Staphylococcus aureus 1199B harboring grlA A116E mutant assessed as inhibition of ethidium bromide efflux at 50 uM measured for 5 mins by fluorometric analysis relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL2385677";"";"0";"400.95";"1";"5.02";"3e";"CCCOc1ccc(-c2cc(OCC(C)N(C)C)c3ccccc3n2)cc1.Cl";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL2390106";"Inhibition of wild type NorA in Staphylococcus aureus 1199 assessed as reduction of ciprofloxacin MIC at 0.78 to 100 ug/mL";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL2385667";"";"0";"448.56";"0";"4.91";"3x";"CCCOc1ccc(-c2cc(OCCN3CCC4(CC3)OCCO4)c3ccccc3n2)cc1";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL2390107";"Inhibition of NorA in Staphylococcus aureus ATCC 25923 assessed as reduction of ciprofloxacin MIC at 0.78 to 100 ug/mL";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL3775105";"";"0";"434.58";"1";"5.43";"6f";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCCN3CCCCC3)cc12";"Inhibition";"'='";"98.5";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3879153";"Inhibition of Staphylococcus aureus 1199B NorA assessed as inhibition of ethidium bromide efflux at 50 uM measured after 5 mins by fluorometric method relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3877305";"1";"Scientific Literature";"J Med Chem";"2017";"None";""
"CHEMBL3929187";"";"0";"646.75";"3";"6.51";"13";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCCNCc3ccc(Oc4nnnn4-c4ccccc4)c(OC)c3)cc12";"Inhibition";"'='";"95.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3879153";"Inhibition of Staphylococcus aureus 1199B NorA assessed as inhibition of ethidium bromide efflux at 50 uM measured after 5 mins by fluorometric method relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3877305";"1";"Scientific Literature";"J Med Chem";"2017";"None";""
"CHEMBL2159001";"";"0";"320.39";"0";"3.39";"17";"CN(C)CCOc1ccc(C(=O)/C=C/c2ccc(C#N)cc2)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL2162181";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml after 150 to 160 secs by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL1651186";"";"0";"468.58";"0";"3.70";"103";"CCOC(=O)c1cn(C2CC2)c2cc(N3CCC4=C(C3)/C(=N/OC)CCS4)c(N)cc2c1=O";"Inhibition";"'='";"74.5";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL145666";"";"0";"314.34";"0";"3.31";"16";"COc1cc(OC)c(/C=C/C(=O)c2ccc(O)cc2)c(OC)c1";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL2162198";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL2158999";"";"0";"338.45";"0";"3.59";"10";"CN(C)CCOc1ccc(C(=O)/C=C/c2ccc(N(C)C)cc2)cc1";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL2162198";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL145203";"";"0";"341.41";"0";"3.67";"12";"COc1ccc(C(=O)/C=C/c2cccc(N(C)C)c2)c(OC)c1OC";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL2162181";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml after 150 to 160 secs by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL1651163";"";"0";"390.53";"0";"4.94";"25f";"CCCOc1ccc(-c2cc(=O)c3ccccc3n2CCN2CCCCC2)cc1";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL1817275";"Inhibition of wild-type norA expressing Staphylococcus aureus 1199 assessed as reduction in ciprofloxacin MIC";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1811797";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL276760";"";"0";"251.29";"0";"2.91";"9";"Cn1c(-c2ccc(O)cc2)cc(=O)c2ccccc21";"Inhibition";"'='";"0.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL4161736";"";"0";"420.55";"1";"5.56";"4b";"CCCOc1ccc(-c2cc(OCCN3CCCCC3)c3ccc(OC)cc3n2)cc1";"Inhibition";"'='";"100.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL2158995";"";"0";"284.31";"0";"3.31";"3";"COc1ccc(/C=C/C(=O)c2ccc(O)cc2)cc1OC";"Inhibition";"'='";"38.3";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2162041";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 5 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL1272";"REPAGLINIDE";"4";"452.60";"1";"5.22";"repaglinide";"CCOc1cc(CC(=O)N[C@@H](CC(C)C)c2ccccc2N2CCCCC2)ccc1C(=O)O";"Inhibition";"'='";"14.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2049765";"Inhibition of norA-mediated ethidium bromide efflux in Staphylococcus aureus SA-1199B harboring grlA A116E mutant at 50 uM after 5 mins by fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2046272";"1";"Scientific Literature";"ACS Med. Chem. Lett.";"2012";"None";""
"CHEMBL1294";"QUINIDINE";"4";"324.42";"0";"3.17";"6";"C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12";"Inhibition";"'='";"31.5";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2049765";"Inhibition of norA-mediated ethidium bromide efflux in Staphylococcus aureus SA-1199B harboring grlA A116E mutant at 50 uM after 5 mins by fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2046272";"1";"Scientific Literature";"ACS Med. Chem. Lett.";"2012";"None";""
"CHEMBL932";"DIPYRIDAMOLE";"4";"504.64";"2";"-0.02";"DIPYRIDAMOLE";"OCCN(CCO)c1nc(N2CCCCC2)c2nc(N(CCO)CCO)nc(N3CCCCC3)c2n1";"Inhibition";"'='";"42.3";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2049765";"Inhibition of norA-mediated ethidium bromide efflux in Staphylococcus aureus SA-1199B harboring grlA A116E mutant at 50 uM after 5 mins by fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2046272";"1";"Scientific Literature";"ACS Med. Chem. Lett.";"2012";"None";""
"CHEMBL1368161";"";"0";"284.27";"0";"2.07";"11, specs codeAG-205/11317135";"Cc1ccc([C@H]2C(C#N)=C(N)Oc3cc(C)oc(=O)c32)o1";"Inhibition";"'='";"0.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651168";"";"0";"293.37";"0";"3.99";"83";"CC(C)Oc1ccc(-c2cc(=O)c3ccccc3n2C)cc1";"Inhibition";"'='";"10.3";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL457110";"";"0";"241.29";"0";"2.79";"26";"NCc1ccc(NC(=O)Nc2ccccc2)cc1";"Inhibition";"'='";"20.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1017717";"Inhibition of NorA efflux pump in Staphylococcus aureus K2361 assessed as reduction of ethidium bromide efflux at 0.5 uM for 5 mins";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1154468";"1";"Scientific Literature";"Eur. J. Med. Chem.";"2008";"None";""
"CHEMBL2385680";"";"0";"406.57";"1";"6.19";"3h";"CCCOc1ccc(-c2cc(OCCN(C(C)C)C(C)C)c3ccccc3n2)cc1";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL2390106";"Inhibition of wild type NorA in Staphylococcus aureus 1199 assessed as reduction of ciprofloxacin MIC at 0.78 to 100 ug/mL";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL1651166";"";"0";"279.34";"0";"3.60";"22e";"CCOc1ccc(-c2cc(=O)c3ccccc3n2C)cc1";"Inhibition";"'='";"10.8";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1817147";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as inhibition of ethidium bromide efflux at 50 uM by fluorimetry";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1811797";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL3775271";"";"0";"452.55";"0";"3.25";"39";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCC(O)CN3CCOCC3)cc12";"Inhibition";"'='";"99.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL3774689";"";"0";"452.57";"1";"5.38";"43";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCC(F)CN3CCCCC3)cc12";"Inhibition";"'='";"96.7";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL3774968";"";"0";"462.63";"1";"5.75";"69";"CCOC(=O)Cc1c(C)n(Cc2ccccc2)c2ccc(OCCCN3CCCCCC3)cc12";"Inhibition";"'='";"98.4";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL1650985";"";"0";"361.40";"0";"2.42";"17, specs codeAG-205/36565028";"Cc1c(NS(=O)(=O)c2ccc(F)cc2)c(=O)n(-c2ccccc2)n1C";"Inhibition";"'='";"3.2";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL490";"PAROXETINE";"4";"329.37";"0";"3.33";"59";"Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1";"Inhibition";"'='";"73.0";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651182";"";"0";"471.55";"0";"4.33";"99";"CCOC(=O)c1cn(C2CC2)c2cc(N3CCC4=C(C3)/C(=N/O)C(C)CS4)c(F)cc2c1=O";"Inhibition";"'='";"22.5";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL12089";"BERBERINE CHLORIDE";"1";"371.82";"0";"3.10";"Berberine";"COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2.[Cl-]";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL1638730";"Inhibition of NorA in Staphylococcus aureus 8325-4 assessed as accumulation of Berberine at 3 uM by fluorescence assay in presence of INF55";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1629702";"1";"Scientific Literature";"Antimicrob. Agents Chemother.";"2010";"None";""
"CHEMBL12089";"BERBERINE CHLORIDE";"1";"371.82";"0";"3.10";"Berberine";"COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2.[Cl-]";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL1638732";"Inhibition of NorA in Staphylococcus aureus 8325-4 assessed as assessed as accumulation of compound at 3 uM by fluorescence assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1629702";"1";"Scientific Literature";"Antimicrob. Agents Chemother.";"2010";"None";""
"CHEMBL4572180";"";"0";"361.87";"0";"3.84";"5";"CC[C@@H](C)[C@H](NC(=O)/C=C/C1=C(Cl)c2ccccc2CC1)C(=O)OC";"Inhibition";"'='";"58.24";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4311538";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM measured after 5 mins by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4308903";"1";"Scientific Literature";"Bioorg Med Chem";"2019";"None";""
"CHEMBL2158996";"";"0";"338.36";"0";"3.61";"7";"C=CCOc1ccccc1C(=O)/C=C/c1ccc(OCC(=O)O)cc1";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL2162198";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL772";"RESERPINE";"4";"608.69";"1";"4.17";"Reserpine";"COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC";"Inhibition";"'='";"30.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2162040";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 2.5 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL4171147";"";"0";"558.68";"2";"6.16";"7d";"CCCOc1ccc(-c2cc(OCCN3CCc4cc(OC)c(OC)cc4C3)c3cc(OC)c(OC)cc3n2)cc1";"Inhibition";"'='";"94.1";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4176869";"";"0";"421.54";"0";"3.98";"3g";"CCCOc1ccc(-c2cc(OCCN3CCNCC3)c3cc(OC)ccc3n2)cc1";"Inhibition";"'='";"84.4";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL2385677";"";"0";"400.95";"1";"5.02";"3e";"CCCOc1ccc(-c2cc(OCC(C)N(C)C)c3ccccc3n2)cc1.Cl";"Inhibition";"'='";"90.4";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2390114";"Inhibition of NorA in Staphylococcus aureus 1199B harboring grlA A116E mutant assessed as inhibition of ethidium bromide efflux at 50 uM measured for 5 mins by fluorometric analysis relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL1651176";"";"0";"339.39";"0";"3.71";"27f";"CCCOc1ccc(-c2cc(=O)c3cc(OC)c(O)cc3n2C)cc1";"Inhibition";"'='";"9.1";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1817147";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as inhibition of ethidium bromide efflux at 50 uM by fluorimetry";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1811797";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL358518";"";"0";"284.31";"0";"3.31";"5";"COc1cc(O)cc(C)c1/C=C/C(=O)c1ccc(O)cc1";"Inhibition";"";"";"";"";"";"tde";"";"";"";"";"";"False";"CHEMBL2162184";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL1651188";"";"0";"441.55";"0";"3.06";"105";"CCOC(=O)c1cn(C2CC2)c2cc(N3CCC4=C(C3)C(O)CCS4)c(N)cc2c1=O";"Inhibition";"'='";"26.3";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651189";"";"0";"453.56";"0";"3.57";"106";"CCOC(=O)c1cn(C2CC2)c2c(C)c(N3CCC4=C(C3)C(=O)CCS4)c(N)cc2c1=O";"Inhibition";"'='";"36.8";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651191";"";"0";"468.58";"0";"3.84";"108";"CCOC(=O)c1cn(C2CC2)c2c(C)c(N3CCC4=C(C3)/C(=N/O)CCS4)c(N)cc2c1=O";"Inhibition";"'='";"36.2";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1650995";"";"0";"476.35";"1";"5.17";"27, specs codeAH-487/41184581";"CC(C)N1C(=O)S/C(=C/c2cc(Br)ccc2OCc2ccc(C(=O)O)cc2)C1=O";"Inhibition";"'='";"3.1";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1650987";"";"0";"402.40";"0";"3.38";"19, specs codeAP-828/41001984";"COc1cc(/C=C2/SC(Nc3ccccc3F)=NC2=O)ccc1OCC(=O)O";"Inhibition";"'='";"11.9";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651179";"";"0";"447.62";"1";"5.49";"96";"CCN(CC)CCOc1cc(-c2ccc(OCCN3CCCCC3)cc2)nc2ccccc12";"Inhibition";"'='";"65.6";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL728";"PROCHLORPERAZINE";"4";"373.95";"0";"4.58";"63";"CN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1";"Inhibition";"'>='";"78.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL2385678";"";"0";"376.50";"1";"5.16";"3f";"CCCOc1ccc(-c2cc(OC3CCCN(C)C3)c3ccccc3n2)cc1";"Inhibition";"'='";"88.2";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2390114";"Inhibition of NorA in Staphylococcus aureus 1199B harboring grlA A116E mutant assessed as inhibition of ethidium bromide efflux at 50 uM measured for 5 mins by fluorometric analysis relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL4174235";"";"0";"493.69";"1";"6.13";"10a";"CCCOc1ccc(-c2cc(OCCN(CC)CC)c3cc(OCCN(CC)CC)ccc3n2)cc1";"Inhibition";"'='";"81.4";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4155967";"Inhibition of Staphylococcus aureus SA-1199B NorA assessed as reduction in EtBr efflux at 50 uM measured over 5 mins by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4152305";"1";"Scientific Literature";"Eur J Med Chem";"2018";"None";""
"CHEMBL1630218";"";"0";"622.08";"2";"6.74";"SS14-P";"COc1ccc2c(Cc3ccc(-c4cc5cc([N+](=O)[O-])ccc5[nH]4)cc3)c3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2.[Cl-]";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL1638736";"Inhibition of NorA in Staphylococcus aureus 8325-4 assessed as increase in ethidium bromide uptake at 3 uM by fluorescence assay in presence of INF55";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1629702";"1";"Scientific Literature";"Antimicrob. Agents Chemother.";"2010";"None";""
"CHEMBL1650997";"";"0";"499.43";"1";"5.85";"29, specs codeAK-968/41016976";"Cc1sc([C@@H]2C(C#N)=C(N)OC3=C2C(=O)CC(C)(C)C3)cc1COc1ccc(Br)cc1";"Inhibition";"'='";"0.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL4169284";"";"0";"450.58";"1";"5.57";"8b";"CCCOc1ccc(-c2cc(OCCN3CCCCC3)c3cc(OC)cc(OC)c3n2)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4151517";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as synergistic potentiation of ciprofloxacin-induced antimicrobial activity at 0.78 to 100 ug/ml by microdilution method based Checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL772";"RESERPINE";"4";"608.69";"1";"4.17";"Reserpine";"COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4311546";"Inhibition of NorA Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 6.25 to 50 uM measured at 5 mins interval for 30 mins by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4308903";"1";"Scientific Literature";"Bioorg Med Chem";"2019";"None";""
"CHEMBL1651181";"";"0";"390.53";"1";"5.56";"29f";"CCCOc1ccc(-c2cc(OCCN3CCCCC3)c3ccccc3n2)cc1";"Inhibition";"'='";"88.5";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL1817147";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as inhibition of ethidium bromide efflux at 50 uM by fluorimetry";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1811797";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL772";"RESERPINE";"4";"608.69";"1";"4.17";"reserpine";"COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC";"Inhibition";"'='";"84.8";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL1817147";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as inhibition of ethidium bromide efflux at 50 uM by fluorimetry";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1811797";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL3945575";"";"0";"747.89";"3";"6.43";"3";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCC(O)CNCC(O)COc3ccc4c(c3)c(C(=O)OCC)c(C)n4Cc3ccccc3)cc12";"Inhibition";"'='";"78.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3879153";"Inhibition of Staphylococcus aureus 1199B NorA assessed as inhibition of ethidium bromide efflux at 50 uM measured after 5 mins by fluorometric method relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3877305";"1";"Scientific Literature";"J Med Chem";"2017";"None";""
"CHEMBL434066";"";"0";"284.31";"0";"3.31";"4";"COc1ccc(/C=C/C(=O)c2ccc(O)cc2)c(OC)c1";"Inhibition";"";"";"";"";"";"tde";"";"";"";"";"";"False";"CHEMBL2162184";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL772";"RESERPINE";"4";"608.69";"1";"4.17";"Reserpine";"COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC";"Inhibition";"'='";"82.0";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL4155967";"Inhibition of Staphylococcus aureus SA-1199B NorA assessed as reduction in EtBr efflux at 50 uM measured over 5 mins by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4152305";"1";"Scientific Literature";"Eur J Med Chem";"2018";"None";""
"CHEMBL2385673";"";"0";"502.66";"2";"7.77";"3t";"CCCOc1ccc(-c2cc(OCCN(Cc3ccccc3)Cc3ccccc3)c3ccccc3n2)cc1";"Inhibition";"'='";"0.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2390114";"Inhibition of NorA in Staphylococcus aureus 1199B harboring grlA A116E mutant assessed as inhibition of ethidium bromide efflux at 50 uM measured for 5 mins by fluorometric analysis relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL3775114";"";"0";"380.49";"0";"4.12";"12";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCN(C)C)cc12";"Inhibition";"'='";"98.2";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL3775842";"";"0";"422.53";"0";"3.89";"22";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCN3CCOCC3)cc12";"Inhibition";"'='";"90.9";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL482124";"";"0";"311.45";"1";"5.34";"6l";"CC(C)CCOc1ccc(C2=Nc3ccccc3SC2)cc1";"Inhibition";"'='";"16.9";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL1015715";"Inhibition of NorA pump-mediated ethidium bromide efflux in Staphylococcus aureus K1199B at 50 uM by fluorimetric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1155078";"1";"Scientific Literature";"J. Med. Chem.";"2008";"None";""
"CHEMBL454789";"";"0";"255.34";"0";"3.92";"6e";"COc1ccccc1C1=Nc2ccccc2SC1";"Inhibition";"'='";"0.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1015715";"Inhibition of NorA pump-mediated ethidium bromide efflux in Staphylococcus aureus K1199B at 50 uM by fluorimetric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1155078";"1";"Scientific Literature";"J. Med. Chem.";"2008";"None";""
"CHEMBL2385688";"";"0";"391.52";"0";"3.97";"3q";"CCCOc1ccc(-c2cc(OCCN3CCNCC3)c3ccccc3n2)cc1";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL2390106";"Inhibition of wild type NorA in Staphylococcus aureus 1199 assessed as reduction of ciprofloxacin MIC at 0.78 to 100 ug/mL";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL2385684";"";"0";"404.55";"1";"5.95";"3m";"CCCOc1ccc(-c2cc(OCCN3CCCCCC3)c3ccccc3n2)cc1";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL2390107";"Inhibition of NorA in Staphylococcus aureus ATCC 25923 assessed as reduction of ciprofloxacin MIC at 0.78 to 100 ug/mL";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL1651165";"";"0";"279.34";"0";"4.40";"20f";"CCCOc1ccc(-c2cc(O)c3ccccc3n2)cc1";"Inhibition";"'='";"0.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1817147";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as inhibition of ethidium bromide efflux at 50 uM by fluorimetry";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1811797";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651173";"";"0";"295.34";"0";"3.22";"23a";"COc1cc2c(=O)cc(-c3ccccc3)n(C)c2cc1OC";"Inhibition";"'='";"9.4";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1817147";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as inhibition of ethidium bromide efflux at 50 uM by fluorimetry";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1811797";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1630218";"";"0";"622.08";"2";"6.74";"SS14-P";"COc1ccc2c(Cc3ccc(-c4cc5cc([N+](=O)[O-])ccc5[nH]4)cc3)c3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2.[Cl-]";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL1638737";"Inhibition of NorA in Staphylococcus aureus K2378 overexpressing NorA assessed as increase in ethidium bromide uptake at 3 uM by fluorescence assay in presence of INF55";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1629702";"1";"Scientific Literature";"Antimicrob. Agents Chemother.";"2010";"None";""
"CHEMBL2158999";"";"0";"338.45";"0";"3.59";"10";"CN(C)CCOc1ccc(C(=O)/C=C/c2ccc(N(C)C)cc2)cc1";"Inhibition";"'='";"48.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2162040";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 2.5 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL2158994";"";"0";"295.38";"0";"3.52";"1";"CN(C)CCOc1ccc(C(=O)/C=C/c2ccccc2)cc1";"Inhibition";"'='";"21.8";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2162040";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 2.5 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL2385667";"";"0";"448.56";"0";"4.91";"3x";"CCCOc1ccc(-c2cc(OCCN3CCC4(CC3)OCCO4)c3ccccc3n2)cc1";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL2390106";"Inhibition of wild type NorA in Staphylococcus aureus 1199 assessed as reduction of ciprofloxacin MIC at 0.78 to 100 ug/mL";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL1651008";"";"0";"391.50";"0";"4.50";"43";"Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)nc(C)n3Cc2ccccc2)cc1";"Inhibition";"'='";"30.6";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651163";"";"0";"390.53";"0";"4.94";"25f";"CCCOc1ccc(-c2cc(=O)c3ccccc3n2CCN2CCCCC2)cc1";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL1817270";"Inhibition of NorA in Staphylococcus aureus 1199B norA++ and A116E GrlA mutation assessed as reduction in ciprofloxacin MIC at 50 ug/mL";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1811797";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL490";"PAROXETINE";"4";"329.37";"0";"3.33";"paroxetine";"Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL1817268";"Inhibition of NorA in Staphylococcus aureus 1199B norA++ and A116E GrlA mutation assessed as reduction in ciprofloxacin MIC at 25 ug/mL";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1811797";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL422481";"";"0";"284.31";"0";"3.31";"6";"COc1ccc(OC)c(/C=C/C(=O)c2ccc(O)cc2)c1";"Inhibition";"'='";"23.3";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2162040";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 2.5 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL482124";"";"0";"311.45";"1";"5.34";"75";"CC(C)CCOc1ccc(C2=Nc3ccccc3SC2)cc1";"Inhibition";"'='";"16.9";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651177";"";"0";"267.28";"0";"2.62";"92";"Cn1c(-c2ccccc2)cc(=O)c2cc(O)c(O)cc21";"Inhibition";"'='";"0.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL2385678";"";"0";"376.50";"1";"5.16";"3f";"CCCOc1ccc(-c2cc(OC3CCCN(C)C3)c3ccccc3n2)cc1";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL2390106";"Inhibition of wild type NorA in Staphylococcus aureus 1199 assessed as reduction of ciprofloxacin MIC at 0.78 to 100 ug/mL";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL2385680";"";"0";"406.57";"1";"6.19";"3h";"CCCOc1ccc(-c2cc(OCCN(C(C)C)C(C)C)c3ccccc3n2)cc1";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL2390107";"Inhibition of NorA in Staphylococcus aureus ATCC 25923 assessed as reduction of ciprofloxacin MIC at 0.78 to 100 ug/mL";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL445769";"";"0";"255.34";"0";"3.92";"68";"COc1ccc(C2=Nc3ccccc3SC2)cc1";"Inhibition";"'='";"19.5";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL2385679";"";"0";"388.51";"1";"5.16";"3g";"CCCOc1ccc(-c2cc(OC3CN4CCC3CC4)c3ccccc3n2)cc1";"Inhibition";"'='";"91.3";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2390114";"Inhibition of NorA in Staphylococcus aureus 1199B harboring grlA A116E mutant assessed as inhibition of ethidium bromide efflux at 50 uM measured for 5 mins by fluorometric analysis relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL772";"RESERPINE";"4";"608.69";"1";"4.17";"Reserpine";"COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL2390106";"Inhibition of wild type NorA in Staphylococcus aureus 1199 assessed as reduction of ciprofloxacin MIC at 0.78 to 100 ug/mL";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL6966";"VERAPAMIL";"4";"454.61";"1";"5.09";"verapamil";"COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC";"Inhibition";"";"";"";"";"";"tde";"";"";"";"";"";"False";"CHEMBL2162184";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL2158997";"";"0";"313.37";"0";"3.66";"8";"CN(C)CCOc1ccc(C(=O)/C=C/c2ccccc2F)cc1";"Inhibition";"";"";"";"";"";"tde";"";"";"";"";"";"False";"CHEMBL2162184";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL2158995";"";"0";"284.31";"0";"3.31";"3";"COc1ccc(/C=C/C(=O)c2ccc(O)cc2)cc1OC";"Inhibition";"'='";"14.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2162040";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 2.5 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL223643";"VALINOMYCIN";"0";"1111.34";"None";"None";"Valinomycin";"CC(C)[C@@H]1NC(=O)[C@H](C)OC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C(C)C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](C)OC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C(C)C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](C)OC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C(C)C)OC1=O";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL2162183";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 10 uM by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL2158994";"";"0";"295.38";"0";"3.52";"1";"CN(C)CCOc1ccc(C(=O)/C=C/c2ccccc2)cc1";"Inhibition";"";"";"";"";"";"tde";"";"";"";"";"";"False";"CHEMBL2162184";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL2159000";"";"0";"388.42";"0";"4.82";"11";"COc1cc(/C=C/C(=O)c2cccc(OC(=O)c3ccccc3)c2)cc(OC)c1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL2162181";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml after 150 to 160 secs by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL1651167";"";"0";"293.37";"0";"3.99";"22f";"CCCOc1ccc(-c2cc(=O)c3ccccc3n2C)cc1";"Inhibition";"'='";"33.9";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1817147";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as inhibition of ethidium bromide efflux at 50 uM by fluorimetry";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1811797";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL276760";"";"0";"251.29";"0";"2.91";"22c";"Cn1c(-c2ccc(O)cc2)cc(=O)c2ccccc21";"Inhibition";"'='";"0.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1817147";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as inhibition of ethidium bromide efflux at 50 uM by fluorimetry";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1811797";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1814795";"";"0";"293.37";"0";"4.70";"21f";"CCCOc1ccc(-c2cc(OC)c3ccccc3n2)cc1";"Inhibition";"'='";"63.7";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1817147";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as inhibition of ethidium bromide efflux at 50 uM by fluorimetry";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1811797";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651193";"";"0";"482.61";"0";"4.01";"110";"CCOC(=O)c1cn(C2CC2)c2c(C)c(N3CCC4=C(C3)/C(=N/OC)CCS4)c(N)cc2c1=O";"Inhibition";"'='";"54.4";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651175";"";"0";"353.42";"0";"4.01";"90";"CCCOc1ccc(-c2cc(=O)c3cc(OC)c(OC)cc3n2C)cc1";"Inhibition";"'='";"0.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651170";"";"0";"350.46";"0";"3.93";"22i";"CCN(CC)CCOc1ccc(-c2cc(=O)c3ccccc3n2C)cc1";"Inhibition";"'='";"1.7";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1817147";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as inhibition of ethidium bromide efflux at 50 uM by fluorimetry";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1811797";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL358518";"";"0";"284.31";"0";"3.31";"5";"COc1cc(O)cc(C)c1/C=C/C(=O)c1ccc(O)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL2162181";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml after 150 to 160 secs by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL434066";"";"0";"284.31";"0";"3.31";"4";"COc1ccc(/C=C/C(=O)c2ccc(O)cc2)c(OC)c1";"Inhibition";"'='";"89.6";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2162179";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 20 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL1651168";"";"0";"293.37";"0";"3.99";"22g";"CC(C)Oc1ccc(-c2cc(=O)c3ccccc3n2C)cc1";"Inhibition";"'='";"10.3";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1817147";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as inhibition of ethidium bromide efflux at 50 uM by fluorimetry";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1811797";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1630217";"";"0";"622.08";"2";"6.74";"SS14-M";"COc1ccc2c(Cc3cccc(-c4cc5cc([N+](=O)[O-])ccc5[nH]4)c3)c3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2.[Cl-]";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL1638734";"Inhibition of NorA in Staphylococcus aureus 8325-4 assessed as ethidium bromide uptake at 3 uM by fluorescence assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1629702";"1";"Scientific Literature";"Antimicrob. Agents Chemother.";"2010";"None";""
"CHEMBL42055";"E-FLUPENTIXOL";"2";"434.53";"0";"4.60";"65";"OCCN1CCN(CC/C=C2\c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1";"Inhibition";"'='";"72.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL3219738";"";"0";"350.44";"0";"0.52";"8";"CN1CCN(c2cc3c(cc2N)C(=O)CS(=O)(=O)N3C2CC2)CC1";"Inhibition";"'='";"7.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3226388";"Inhibition of NorA efflux pump in Staphylococcus aureus SA-1199B assessed as inhibition of EtBr efflux at 50 uM";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3217728";"1";"Scientific Literature";"MedChemComm";"2012";"None";""
"CHEMBL772";"RESERPINE";"4";"608.69";"1";"4.17";"Reserpine";"COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC";"Inhibition";"'='";"85.0";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL3226388";"Inhibition of NorA efflux pump in Staphylococcus aureus SA-1199B assessed as inhibition of EtBr efflux at 50 uM";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3217728";"1";"Scientific Literature";"MedChemComm";"2012";"None";""
"CHEMBL3775416";"";"0";"456.59";"1";"5.73";"31";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCCNCc3ccccc3)cc12";"Inhibition";"'='";"45.4";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL71";"CHLORPROMAZINE";"4";"318.87";"0";"4.89";"chlorpromazine";"CN(C)CCCN1c2ccccc2Sc2ccc(Cl)cc21";"Inhibition";"'='";"81.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1015715";"Inhibition of NorA pump-mediated ethidium bromide efflux in Staphylococcus aureus K1199B at 50 uM by fluorimetric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1155078";"1";"Scientific Literature";"J. Med. Chem.";"2008";"None";""
"CHEMBL480166";"";"0";"315.39";"0";"3.94";"6h";"COc1cc(C2=Nc3ccccc3SC2)cc(OC)c1OC";"Inhibition";"'='";"23.6";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL1015715";"Inhibition of NorA pump-mediated ethidium bromide efflux in Staphylococcus aureus K1199B at 50 uM by fluorimetric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1155078";"1";"Scientific Literature";"J. Med. Chem.";"2008";"None";""
"CHEMBL3775619";"";"0";"413.52";"1";"5.80";"11";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCc3ccccc3)cc12";"Inhibition";"'='";"4.7";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL3775147";"";"0";"338.36";"0";"4.08";"7";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc([N+](=O)[O-])cc12";"Inhibition";"'='";"9.1";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL3775841";"";"0";"366.46";"0";"3.90";"34";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCCN)cc12";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL3778150";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199 assessed as potentiation of ciprofloxacin-mediated antibacterial activity";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL3775871";"";"0";"502.58";"2";"6.45";"60";"CCOC(=O)c1c(C)n(Cc2ccc(C(F)(F)F)cc2)c2ccc(OCCCN3CCCCC3)cc12";"Inhibition";"'='";"77.7";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL3774520";"";"0";"452.57";"1";"5.57";"56";"CCOC(=O)c1c(C)n(Cc2ccccc2F)c2ccc(OCCCN3CCCCC3)cc12";"Inhibition";"'='";"89.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL118";"CELECOXIB";"4";"381.38";"0";"3.51";"Celecoxib";"Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL2051687";"Inhibition of norA overexpressed in Staphylococcus aureus SA1199B coexpressing A116E GrlA mutation assessed as potentiation of ciprofloxacin MIC by checkerboard assay";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2046274";"1";"Scientific Literature";"J. Med. Chem.";"2012";"None";""
"CHEMBL296419";"ASTEMIZOLE";"4";"458.58";"1";"5.35";"3";"COc1ccc(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1";"Inhibition";"'='";"80.6";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL2049765";"Inhibition of norA-mediated ethidium bromide efflux in Staphylococcus aureus SA-1199B harboring grlA A116E mutant at 50 uM after 5 mins by fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2046272";"1";"Scientific Literature";"ACS Med. Chem. Lett.";"2012";"None";""
"CHEMBL12713";"SERTINDOLE";"4";"440.95";"0";"4.63";"9";"O=C1NCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(Cl)cc23)CC1";"Inhibition";"'='";"81.8";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2049765";"Inhibition of norA-mediated ethidium bromide efflux in Staphylococcus aureus SA-1199B harboring grlA A116E mutant at 50 uM after 5 mins by fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2046272";"1";"Scientific Literature";"ACS Med. Chem. Lett.";"2012";"None";""
"CHEMBL12089";"BERBERINE CHLORIDE";"1";"371.82";"0";"3.10";"Berberine";"COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2.[Cl-]";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL1638728";"Inhibition of NorA in Staphylococcus aureus 8325-4 assessed as accumulation of compound at 3 uM by fluorescence assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1629702";"1";"Scientific Literature";"Antimicrob. Agents Chemother.";"2010";"None";""
"CHEMBL4164737";"";"0";"408.54";"1";"5.42";"3a";"CCCOc1ccc(-c2cc(OCCN(CC)CC)c3cc(OC)ccc3n2)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4151517";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as synergistic potentiation of ciprofloxacin-induced antimicrobial activity at 0.78 to 100 ug/ml by microdilution method based Checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL1650991";"";"0";"420.46";"1";"5.48";"23, specs codeAM-807/41624543";"CC[C@H]1CCc2nc(SCc3ccc(C(=O)O)cc3)c(C#N)c(C(F)(F)F)c2C1";"Inhibition";"'='";"71.7";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL54661";"FLUPENTIXOL";"3";"434.53";"0";"4.60";"64";"OCCN1CCN(CC/C=C2/c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1";"Inhibition";"'='";"82.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL454789";"";"0";"255.34";"0";"3.92";"74";"COc1ccccc1C1=Nc2ccccc2SC1";"Inhibition";"'='";"0.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL575569";"CIPROFLOXACIN ETHYL ESTER";"0";"359.40";"0";"2.06";"113, Ciprofloxacin ethyl ester";"CCOC(=O)c1cn(C2CC2)c2cc(N3CCNCC3)c(F)cc2c1=O";"Inhibition";"'='";"20.8";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL2158995";"";"0";"284.31";"0";"3.31";"3";"COc1ccc(/C=C/C(=O)c2ccc(O)cc2)cc1OC";"Inhibition";"'='";"87.9";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2162179";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 20 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL2385675";"";"0";"322.41";"0";"4.03";"3y";"CCCOc1ccc(-c2cc(OCCN)c3ccccc3n2)cc1";"Inhibition";"'='";"96.1";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2390114";"Inhibition of NorA in Staphylococcus aureus 1199B harboring grlA A116E mutant assessed as inhibition of ethidium bromide efflux at 50 uM measured for 5 mins by fluorometric analysis relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL3774891";"";"0";"464.61";"1";"5.44";"54";"CCOC(=O)c1c(C)n(Cc2cccc(OC)c2)c2ccc(OCCCN3CCCCC3)cc12";"Inhibition";"'='";"77.1";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL2158999";"";"0";"338.45";"0";"3.59";"10";"CN(C)CCOc1ccc(C(=O)/C=C/c2ccc(N(C)C)cc2)cc1";"Inhibition";"'='";"96.5";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2162041";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 5 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL223643";"VALINOMYCIN";"0";"1111.34";"None";"None";"Valinomycin";"CC(C)[C@@H]1NC(=O)[C@H](C)OC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C(C)C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](C)OC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C(C)C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](C)OC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C(C)C)OC1=O";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL2162182";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 10 uM after 150 to 160 secs by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL2158992";"";"0";"313.37";"0";"3.66";"19";"CN(C)CCOc1ccc(C(=O)/C=C/c2ccc(F)cc2)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL2162181";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml after 150 to 160 secs by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL142493";"";"0";"284.31";"0";"3.31";"2";"COc1cccc(/C=C/C(=O)c2ccc(O)cc2)c1OC";"Inhibition";"'='";"90.8";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2162179";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 20 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL358518";"";"0";"284.31";"0";"3.31";"5";"COc1cc(O)cc(C)c1/C=C/C(=O)c1ccc(O)cc1";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL2162198";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL4175374";"";"0";"533.71";"2";"5.66";"11c";"CCCOc1ccc(-c2cc(OCCN3CCCCC3)c3cc(OCCCN4CCOCC4)ccc3n2)cc1";"Inhibition";"'='";"93.2";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4155967";"Inhibition of Staphylococcus aureus SA-1199B NorA assessed as reduction in EtBr efflux at 50 uM measured over 5 mins by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4152305";"1";"Scientific Literature";"Eur J Med Chem";"2018";"None";""
"CHEMBL4175014";"";"0";"558.68";"2";"6.16";"6d";"CCCOc1ccc(-c2cc(OCCN3CCc4cc(OC)c(OC)cc4C3)c3c(OC)cc(OC)cc3n2)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4151517";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as synergistic potentiation of ciprofloxacin-induced antimicrobial activity at 0.78 to 100 ug/ml by microdilution method based Checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4172225";"";"0";"464.61";"1";"5.96";"8c";"CCCOc1ccc(-c2cc(OCCN3CCCCCC3)c3cc(OC)cc(OC)c3n2)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4151518";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as synergistic potentiation of ciprofloxacin-induced antimicrobial activity at 0.78 ug/ml by microdilution method based Checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL2158998";"";"0";"387.48";"1";"5.32";"9";"CN(C)CCOc1ccc(C(=O)/C=C/c2ccc(Oc3ccccc3)cc2)cc1";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL2162198";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL2158995";"";"0";"284.31";"0";"3.31";"3";"COc1ccc(/C=C/C(=O)c2ccc(O)cc2)cc1OC";"Inhibition";"'='";"64.3";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2162042";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 10 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL2158995";"";"0";"284.31";"0";"3.31";"3";"COc1ccc(/C=C/C(=O)c2ccc(O)cc2)cc1OC";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL2162198";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL1642586";"";"0";"724.67";"3";"4.72";"NP";"C[C@@H]1O[C@@H](Oc2c(-c3ccc(O)cc3)oc3cc(O)cc(O)c3c2=O)[C@H](OC(=O)/C=C/c2ccc(O)cc2)[C@H](O)[C@H]1OC(=O)/C=C/c1ccc(O)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL2162181";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml after 150 to 160 secs by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL2158992";"";"0";"313.37";"0";"3.66";"19";"CN(C)CCOc1ccc(C(=O)/C=C/c2ccc(F)cc2)cc1";"Inhibition";"";"";"";"";"";"tde";"";"";"";"";"";"False";"CHEMBL2162184";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL2385676";"";"0";"400.95";"1";"5.02";"3d";"CCCOc1ccc(-c2cc(OC(C)CN(C)C)c3ccccc3n2)cc1.Cl";"Inhibition";"'='";"86.2";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2390114";"Inhibition of NorA in Staphylococcus aureus 1199B harboring grlA A116E mutant assessed as inhibition of ethidium bromide efflux at 50 uM measured for 5 mins by fluorometric analysis relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL772";"RESERPINE";"4";"608.69";"1";"4.17";"14";"COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4043398";"Inhibition of NorA in Staphylococcus aureus SA1199B harboring GrlA A116E mutant assessed as potentiation of CPX-induced antimicrobial activity up to 100 ug/ml by checkerboard assay";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4043064";"1";"Scientific Literature";"J Med Chem";"2017";"None";""
"CHEMBL3967791";"";"0";"632.72";"3";"6.12";"12";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCNCc3ccc(Oc4nnnn4-c4ccccc4)c(OC)c3)cc12";"Inhibition";"'='";"50.3";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3879153";"Inhibition of Staphylococcus aureus 1199B NorA assessed as inhibition of ethidium bromide efflux at 50 uM measured after 5 mins by fluorometric method relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3877305";"1";"Scientific Literature";"J Med Chem";"2017";"None";""
"CHEMBL3899241";"";"0";"645.84";"2";"7.70";"7";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCCN3CCN(CCCOc4ccccc4-c4ccccc4)CC3)cc12";"Inhibition";"'='";"12.1";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3879153";"Inhibition of Staphylococcus aureus 1199B NorA assessed as inhibition of ethidium bromide efflux at 50 uM measured after 5 mins by fluorometric method relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3877305";"1";"Scientific Literature";"J Med Chem";"2017";"None";""
"CHEMBL2385681";"";"0";"400.95";"1";"5.02";"3i";"CCCOc1ccc(-c2cc(OCCCN(C)C)c3ccccc3n2)cc1.Cl";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL2390106";"Inhibition of wild type NorA in Staphylococcus aureus 1199 assessed as reduction of ciprofloxacin MIC at 0.78 to 100 ug/mL";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL2158995";"";"0";"284.31";"0";"3.31";"3";"COc1ccc(/C=C/C(=O)c2ccc(O)cc2)cc1OC";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL2162181";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml after 150 to 160 secs by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL772";"RESERPINE";"4";"608.69";"1";"4.17";"Reserpine";"COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL2390107";"Inhibition of NorA in Staphylococcus aureus ATCC 25923 assessed as reduction of ciprofloxacin MIC at 0.78 to 100 ug/mL";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL445769";"";"0";"255.34";"0";"3.92";"6d";"COc1ccc(C2=Nc3ccccc3SC2)cc1";"Inhibition";"'='";"19.5";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL1015715";"Inhibition of NorA pump-mediated ethidium bromide efflux in Staphylococcus aureus K1199B at 50 uM by fluorimetric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1155078";"1";"Scientific Literature";"J. Med. Chem.";"2008";"None";""
"CHEMBL4172633";"";"0";"434.58";"1";"5.95";"2c";"CCCOc1ccc(-c2cc(OCCN3CCCCCC3)c3c(OC)cccc3n2)cc1";"Inhibition";"'='";"74.8";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4172781";"";"0";"421.54";"0";"3.98";"4g";"CCCOc1ccc(-c2cc(OCCN3CCNCC3)c3ccc(OC)cc3n2)cc1";"Inhibition";"'='";"100.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4164881";"";"0";"408.54";"1";"5.42";"5a";"CCCOc1ccc(-c2cc(OCCN(CC)CC)c3cccc(OC)c3n2)cc1";"Inhibition";"'='";"83.1";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL772";"RESERPINE";"4";"608.69";"1";"4.17";"reserpine";"COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC";"Inhibition";"'='";"81.6";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL1015715";"Inhibition of NorA pump-mediated ethidium bromide efflux in Staphylococcus aureus K1199B at 50 uM by fluorimetric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1155078";"1";"Scientific Literature";"J. Med. Chem.";"2008";"None";""
"CHEMBL4466235";"";"0";"444.02";"1";"5.79";"11";"COC(=O)CC1(NC(=O)/C=C/C2=C(Cl)c3ccccc3CC2)CCC(C(C)(C)C)CC1";"Inhibition";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL4311538";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM measured after 5 mins by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4308903";"1";"Scientific Literature";"Bioorg Med Chem";"2019";"None";""
"CHEMBL1651179";"";"0";"447.62";"1";"5.49";"28j";"CCN(CC)CCOc1cc(-c2ccc(OCCN3CCCCC3)cc2)nc2ccccc12";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL1817275";"Inhibition of wild-type norA expressing Staphylococcus aureus 1199 assessed as reduction in ciprofloxacin MIC";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1811797";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL422481";"";"0";"284.31";"0";"3.31";"6";"COc1ccc(OC)c(/C=C/C(=O)c2ccc(O)cc2)c1";"Inhibition";"'='";"91.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2162179";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 20 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL434066";"";"0";"284.31";"0";"3.31";"4";"COc1ccc(/C=C/C(=O)c2ccc(O)cc2)c(OC)c1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL2162181";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml after 150 to 160 secs by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL103667";"DORAMAPIMOD";"2";"527.67";"2";"5.99";"78; BIRB 796";"Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1";"Inhibition";"'='";"47.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4043389";"Inhibition of NorA in Staphylococcus aureus SA1199B harboring GrlA A116E mutant assessed as inhibition of ethidium bromide efflux at 50 uM measured after 5 mins by fluorometric method relative to control";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4043064";"1";"Scientific Literature";"J Med Chem";"2017";"None";""
"CHEMBL1651179";"";"0";"447.62";"1";"5.49";"28j";"CCN(CC)CCOc1cc(-c2ccc(OCCN3CCCCC3)cc2)nc2ccccc12";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL1817269";"Inhibition of NorA in Staphylococcus aureus 1199B norA++ and A116E GrlA mutation assessed as reduction in ciprofloxacin MIC at 100 ug/mL";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1811797";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL482125";"";"0";"293.31";"0";"4.93";"77";"FC(F)(F)c1ccc2c(c1)N=C(c1ccccc1)CS2";"Inhibition";"'='";"8.4";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651173";"";"0";"295.34";"0";"3.22";"88";"COc1cc2c(=O)cc(-c3ccccc3)n(C)c2cc1OC";"Inhibition";"'='";"9.4";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651183";"";"0";"485.58";"0";"4.50";"100";"CCOC(=O)c1cn(C2CC2)c2cc(N3CCC4=C(C3)/C(=N/OC)C(C)CS4)c(F)cc2c1=O";"Inhibition";"'='";"86.9";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651165";"";"0";"279.34";"0";"4.40";"6";"CCCOc1ccc(-c2cc(O)c3ccccc3n2)cc1";"Inhibition";"'='";"0.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL772";"RESERPINE";"4";"608.69";"1";"4.17";"Reserpine";"COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC";"Inhibition";"'='";"73.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3419628";"Inhibition of NorA in fluoroquinolone-resistant Staphylococcus aureus 1199B assessed as increase in ethidium bromide uptake at 5 to 20 ug/ml after 20 mins by fluorimetry";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3414455";"1";"Scientific Literature";"Eur. J. Med. Chem.";"2015";"None";""
"CHEMBL2158994";"";"0";"295.38";"0";"3.52";"1";"CN(C)CCOc1ccc(C(=O)/C=C/c2ccccc2)cc1";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL2162198";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL2158994";"";"0";"295.38";"0";"3.52";"1";"CN(C)CCOc1ccc(C(=O)/C=C/c2ccccc2)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL2162181";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml after 150 to 160 secs by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL444694";"";"0";"243.31";"0";"4.05";"6i";"Fc1ccc(C2=Nc3ccccc3SC2)cc1";"Inhibition";"'='";"0.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1015715";"Inhibition of NorA pump-mediated ethidium bromide efflux in Staphylococcus aureus K1199B at 50 uM by fluorimetric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1155078";"1";"Scientific Literature";"J. Med. Chem.";"2008";"None";""
"CHEMBL3775236";"";"0";"449.60";"0";"4.24";"30";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCCCN3CCNCC3)cc12";"Inhibition";"'='";"71.9";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL2385671";"";"0";"372.47";"1";"5.57";"3c";"CCCOc1ccc(-c2cc(OCCn3cccc3)c3ccccc3n2)cc1";"Inhibition";"'='";"4.1";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2390114";"Inhibition of NorA in Staphylococcus aureus 1199B harboring grlA A116E mutant assessed as inhibition of ethidium bromide efflux at 50 uM measured for 5 mins by fluorometric analysis relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL1651166";"";"0";"279.34";"0";"3.60";"81";"CCOc1ccc(-c2cc(=O)c3ccccc3n2C)cc1";"Inhibition";"'='";"10.8";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL3774582";"";"0";"448.61";"1";"5.62";"48";"CCOC(=O)c1c(C)n(CCc2ccccc2)c2ccc(OCCCN3CCCCC3)cc12";"Inhibition";"'='";"99.3";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL2158997";"";"0";"313.37";"0";"3.66";"8";"CN(C)CCOc1ccc(C(=O)/C=C/c2ccccc2F)cc1";"Inhibition";"'='";"97.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2162179";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 20 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL142493";"";"0";"284.31";"0";"3.31";"2";"COc1cccc(/C=C/C(=O)c2ccc(O)cc2)c1OC";"Inhibition";"'='";"11.7";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2162040";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 2.5 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL1642586";"";"0";"724.67";"3";"4.72";"NP";"C[C@@H]1O[C@@H](Oc2c(-c3ccc(O)cc3)oc3cc(O)cc(O)c3c2=O)[C@H](OC(=O)/C=C/c2ccc(O)cc2)[C@H](O)[C@H]1OC(=O)/C=C/c1ccc(O)cc1";"Inhibition";"";"";"";"";"";"tde";"";"";"";"";"";"False";"CHEMBL2162184";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL2158996";"";"0";"338.36";"0";"3.61";"7";"C=CCOc1ccccc1C(=O)/C=C/c1ccc(OCC(=O)O)cc1";"Inhibition";"'='";"14.7";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2162040";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 2.5 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL434066";"";"0";"284.31";"0";"3.31";"4";"COc1ccc(/C=C/C(=O)c2ccc(O)cc2)c(OC)c1";"Inhibition";"'='";"17.3";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2162040";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 2.5 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL4516749";"";"0";"347.84";"0";"3.45";"4";"COC(=O)[C@@H](NC(=O)/C=C/C1=C(Cl)c2ccccc2CC1)C(C)C";"Inhibition";"'>'";"80.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4311545";"Inhibition of NorA Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 6.25 to 50 uM measured after 5 mins by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4308903";"1";"Scientific Literature";"Bioorg Med Chem";"2019";"None";""
"CHEMBL145203";"";"0";"341.41";"0";"3.67";"12";"COc1ccc(C(=O)/C=C/c2cccc(N(C)C)c2)c(OC)c1OC";"Inhibition";"";"";"";"";"";"tde";"";"";"";"";"";"False";"CHEMBL2162184";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL2158999";"";"0";"338.45";"0";"3.59";"10";"CN(C)CCOc1ccc(C(=O)/C=C/c2ccc(N(C)C)cc2)cc1";"Inhibition";"";"";"";"";"";"tde";"";"";"";"";"";"False";"CHEMBL2162184";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL2158995";"";"0";"284.31";"0";"3.31";"3";"COc1ccc(/C=C/C(=O)c2ccc(O)cc2)cc1OC";"Inhibition";"";"";"";"";"";"tde";"";"";"";"";"";"False";"CHEMBL2162184";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL2158996";"";"0";"338.36";"0";"3.61";"7";"C=CCOc1ccccc1C(=O)/C=C/c1ccc(OCC(=O)O)cc1";"Inhibition";"'='";"79.9";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2162042";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 10 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL4172225";"";"0";"464.61";"1";"5.96";"8c";"CCCOc1ccc(-c2cc(OCCN3CCCCCC3)c3cc(OC)cc(OC)c3n2)cc1";"Inhibition";"'='";"80.3";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4167074";"";"0";"434.58";"1";"5.95";"4c";"CCCOc1ccc(-c2cc(OCCN3CCCCCC3)c3ccc(OC)cc3n2)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4151518";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as synergistic potentiation of ciprofloxacin-induced antimicrobial activity at 0.78 ug/ml by microdilution method based Checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL1651181";"";"0";"390.53";"1";"5.56";"2";"CCCOc1ccc(-c2cc(OCCN3CCCCC3)c3ccccc3n2)cc1";"Inhibition";"'='";"88.6";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4155967";"Inhibition of Staphylococcus aureus SA-1199B NorA assessed as reduction in EtBr efflux at 50 uM measured over 5 mins by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4152305";"1";"Scientific Literature";"Eur J Med Chem";"2018";"None";""
"CHEMBL1517085";"";"0";"464.55";"1";"5.74";"34, specs codeAG-690/40702076";"O=C(CSc1nnc(CNc2ccc(F)cc2)o1)N1c2ccccc2Sc2ccccc21";"Inhibition";"'='";"11.5";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1650994";"";"0";"580.38";"2";"5.40";"26, specs codeAP-970/41128510";"C=CCOc1c(I)cc(/C=C2\C(=O)N(c3ccc(C(=O)O)cc3)N=C2c2ccccc2)cc1OC";"Inhibition";"'='";"3.8";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1509012";"";"0";"265.31";"0";"3.21";"80";"COc1ccc(-c2cc(=O)c3ccccc3n2C)cc1";"Inhibition";"'='";"0.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL2158996";"";"0";"338.36";"0";"3.61";"7";"C=CCOc1ccccc1C(=O)/C=C/c1ccc(OCC(=O)O)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL2162181";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml after 150 to 160 secs by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL1651164";"";"0";"296.39";"0";"4.72";"79";"CCCOc1ccc(-c2cc(=O)c3ccccc3s2)cc1";"Inhibition";"'='";"6.3";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1630217";"";"0";"622.08";"2";"6.74";"SS14-M";"COc1ccc2c(Cc3cccc(-c4cc5cc([N+](=O)[O-])ccc5[nH]4)c3)c3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2.[Cl-]";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL1638733";"Inhibition of NorA in Staphylococcus aureus K2378 overexpressing NorA assessed as ethidium bromide uptake at 3 uM by fluorescence assay in presence of INF55";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1629702";"1";"Scientific Literature";"Antimicrob. Agents Chemother.";"2010";"None";""
"CHEMBL12089";"BERBERINE CHLORIDE";"1";"371.82";"0";"3.10";"Berberine";"COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2.[Cl-]";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL1638731";"Inhibition of NorA in Staphylococcus aureus K2378 overexpressing NorA assessed as accumulation of Berberine at 3 uM by fluorescence assay in presence of INF55";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1629702";"1";"Scientific Literature";"Antimicrob. Agents Chemother.";"2010";"None";""
"CHEMBL2158997";"";"0";"313.37";"0";"3.66";"8";"CN(C)CCOc1ccc(C(=O)/C=C/c2ccccc2F)cc1";"Inhibition";"'='";"70.3";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2162042";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 10 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL145203";"";"0";"341.41";"0";"3.67";"12";"COc1ccc(C(=O)/C=C/c2cccc(N(C)C)c2)c(OC)c1OC";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL2162198";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL1492652";"";"0";"366.45";"0";"3.68";"10";"Cc1ccc(S(=O)(=O)Nc2ccc3[nH]c(-c4cccn4C)nc3c2)cc1";"Inhibition";"'='";"88.2";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2390114";"Inhibition of NorA in Staphylococcus aureus 1199B harboring grlA A116E mutant assessed as inhibition of ethidium bromide efflux at 50 uM measured for 5 mins by fluorometric analysis relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL90145";"";"0";"280.32";"0";"4.25";"4";"CCCOc1ccc(-c2cc(=O)c3ccccc3o2)cc1";"Inhibition";"'='";"32.4";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL481679";"";"0";"273.43";"0";"4.67";"73";"CSc1ccc(C2CSc3ccccc3N2)cc1";"Inhibition";"'='";"28.2";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL3219737";"";"0";"422.51";"0";"1.12";"7";"CCOC(=O)C1=C(O)c2cc(N)c(N3CCN(C)CC3)cc2N(C2CC2)S1(=O)=O";"Inhibition";"'='";"0.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3226388";"Inhibition of NorA efflux pump in Staphylococcus aureus SA-1199B assessed as inhibition of EtBr efflux at 50 uM";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3217728";"1";"Scientific Literature";"MedChemComm";"2012";"None";""
"CHEMBL1651006";"";"0";"445.50";"0";"4.55";"38, specs codeAG-205/36712046";"O=C(O)c1ccc(N2C(=O)C[C@@H](S/C(=N\c3ccccc3)Nc3ccccc3)C2=O)cc1";"Inhibition";"'='";"0.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1650984";"";"0";"362.44";"0";"2.38";"14, specs codeAG-205/13056088";"CCc1c(O)nc(SCC(=O)Nc2nc3ccccc3s2)[nH]c1=O";"Inhibition";"'='";"19.1";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL445589";"";"0";"257.36";"0";"3.95";"72";"COc1ccc(C2CSc3ccccc3N2)cc1";"Inhibition";"'='";"10.4";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL305660";"EBASTINE";"3";"469.67";"1";"7.22";"8";"CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1";"Inhibition";"'='";"88.3";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2049765";"Inhibition of norA-mediated ethidium bromide efflux in Staphylococcus aureus SA-1199B harboring grlA A116E mutant at 50 uM after 5 mins by fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2046272";"1";"Scientific Literature";"ACS Med. Chem. Lett.";"2012";"None";""
"CHEMBL1491";"AMLODIPINE";"4";"408.88";"0";"2.27";"2";"CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl";"Inhibition";"'='";"60.6";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2049765";"Inhibition of norA-mediated ethidium bromide efflux in Staphylococcus aureus SA-1199B harboring grlA A116E mutant at 50 uM after 5 mins by fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2046272";"1";"Scientific Literature";"ACS Med. Chem. Lett.";"2012";"None";""
"CHEMBL2385674";"";"0";"452.51";"1";"5.37";"3w";"CCCOc1ccc(-c2cc(OCCN3C(=O)c4ccccc4C3=O)c3ccccc3n2)cc1";"Inhibition";"'='";"8.3";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2390114";"Inhibition of NorA in Staphylococcus aureus 1199B harboring grlA A116E mutant assessed as inhibition of ethidium bromide efflux at 50 uM measured for 5 mins by fluorometric analysis relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL104677";"";"0";"329.37";"0";"3.33";"paroxetine-isomer";"Fc1ccc([C@H]2CCNC[C@@H]2COc2ccc3c(c2)OCO3)cc1";"Inhibition";"'='";"85.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2390114";"Inhibition of NorA in Staphylococcus aureus 1199B harboring grlA A116E mutant assessed as inhibition of ethidium bromide efflux at 50 uM measured for 5 mins by fluorometric analysis relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL2048632";"";"0";"452.88";"0";"4.88";"3g";"O=[N+]([O-])c1ccc(-n2nc(-c3ccc(Cl)cc3)c3c2-c2ccccc2S(=O)(=O)N3)cc1";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL2051686";"Inhibition of norA in wild type Staphylococcus aureus SA1199 expressing assessed as potentiation of ciprofloxacin MIC by checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2046274";"1";"Scientific Literature";"J. Med. Chem.";"2012";"None";""
"CHEMBL2048632";"";"0";"452.88";"0";"4.88";"3g";"O=[N+]([O-])c1ccc(-n2nc(-c3ccc(Cl)cc3)c3c2-c2ccccc2S(=O)(=O)N3)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL2051692";"Inhibition of norA overexpressed in Staphylococcus aureus SAK2378 assessed as potentiation of CPX MIC by checkerboard assay";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2046274";"1";"Scientific Literature";"J. Med. Chem.";"2012";"None";""
"CHEMBL1650989";"";"0";"347.46";"0";"4.48";"21, specs codeAN-465/42885978";"C[C@@H](NCc1cccc(OCc2ccccc2)c1)[C@@H](O)c1ccccc1";"Inhibition";"'='";"86.6";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL2158996";"";"0";"338.36";"0";"3.61";"7";"C=CCOc1ccccc1C(=O)/C=C/c1ccc(OCC(=O)O)cc1";"Inhibition";"'='";"87.1";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2162179";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 20 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL2158994";"";"0";"295.38";"0";"3.52";"1";"CN(C)CCOc1ccc(C(=O)/C=C/c2ccccc2)cc1";"Inhibition";"'='";"56.9";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2162042";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 10 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL1650992";"";"0";"456.52";"0";"3.80";"24, specs codeAH-487/41138989";"COCCN1C(=O)/C(=C/c2ccc(O[C@@H](C)C(=O)O)c(OC)c2)S/C1=N\c1ccccc1";"Inhibition";"'='";"10.6";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL2158998";"";"0";"387.48";"1";"5.32";"9";"CN(C)CCOc1ccc(C(=O)/C=C/c2ccc(Oc3ccccc3)cc2)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL2162181";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml after 150 to 160 secs by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL2158994";"";"0";"295.38";"0";"3.52";"1";"CN(C)CCOc1ccc(C(=O)/C=C/c2ccccc2)cc1";"Inhibition";"'='";"36.1";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2162041";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 5 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL358518";"";"0";"284.31";"0";"3.31";"5";"COc1cc(O)cc(C)c1/C=C/C(=O)c1ccc(O)cc1";"Inhibition";"'='";"63.7";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2162041";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 5 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL726";"FLUPHENAZINE";"4";"437.53";"0";"4.31";"61";"OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1";"Inhibition";"'='";"75.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651002";"";"0";"435.94";"1";"5.89";"32, specs codeAG-690/40751424";"Cc1ccc(-n2c(SCc3ccc(C(=O)O)cc3)nnc2-c2ccc(Cl)cc2)cc1";"Inhibition";"'='";"1.3";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1650999";"";"0";"456.57";"1";"6.43";"37, specs codeAN-655/13869026";"Cc1cc(C)cc(/N=C2\S/C(=C\c3ccc(C(=O)O)cc3)C(=O)N2c2cc(C)cc(C)c2)c1";"Inhibition";"'='";"55.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL772";"RESERPINE";"4";"608.69";"1";"4.17";"Reserpine";"COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL2051686";"Inhibition of norA in wild type Staphylococcus aureus SA1199 expressing assessed as potentiation of ciprofloxacin MIC by checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2046274";"1";"Scientific Literature";"J. Med. Chem.";"2012";"None";""
"CHEMBL1630218";"";"0";"622.08";"2";"6.74";"SS14-P";"COc1ccc2c(Cc3ccc(-c4cc5cc([N+](=O)[O-])ccc5[nH]4)cc3)c3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2.[Cl-]";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL1638733";"Inhibition of NorA in Staphylococcus aureus K2378 overexpressing NorA assessed as ethidium bromide uptake at 3 uM by fluorescence assay in presence of INF55";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1629702";"1";"Scientific Literature";"Antimicrob. Agents Chemother.";"2010";"None";""
"CHEMBL4172225";"";"0";"464.61";"1";"5.96";"8c";"CCCOc1ccc(-c2cc(OCCN3CCCCCC3)c3cc(OC)cc(OC)c3n2)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4151517";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as synergistic potentiation of ciprofloxacin-induced antimicrobial activity at 0.78 to 100 ug/ml by microdilution method based Checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL1651179";"";"0";"447.62";"1";"5.49";"28j";"CCN(CC)CCOc1cc(-c2ccc(OCCN3CCCCC3)cc2)nc2ccccc12";"Inhibition";"'='";"65.6";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1817147";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as inhibition of ethidium bromide efflux at 50 uM by fluorimetry";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1811797";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL772";"RESERPINE";"4";"608.69";"1";"4.17";"Reserpine";"COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC";"Inhibition";"'='";"81.0";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL1017714";"Inhibition of NorA efflux pump in Staphylococcus aureus K2361 assessed as reduction of ethidium bromide efflux at 30 uM for 5 mins";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1154468";"1";"Scientific Literature";"Eur. J. Med. Chem.";"2008";"None";""
"CHEMBL4172781";"";"0";"421.54";"0";"3.98";"4g";"CCCOc1ccc(-c2cc(OCCN3CCNCC3)c3ccc(OC)cc3n2)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4151517";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as synergistic potentiation of ciprofloxacin-induced antimicrobial activity at 0.78 to 100 ug/ml by microdilution method based Checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL445549";"";"0";"270.31";"0";"3.82";"76";"O=[N+]([O-])c1ccc(C2=Nc3ccccc3SC2)cc1";"Inhibition";"'='";"19.6";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651180";"";"0";"378.52";"1";"5.41";"1";"CCCOc1ccc(-c2cc(OCCN(CC)CC)c3ccccc3n2)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4043397";"Inhibition of Staphylococcus aureus SAK2378 norA assessed as potentiation of CPX-induced antimicrobial activity up to 100 ug/ml by checkerboard assay";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4043064";"1";"Scientific Literature";"J Med Chem";"2017";"None";""
"CHEMBL4176571";"";"0";"394.52";"1";"5.03";"5e";"CCCOc1ccc(-c2cc(OCCCN(C)C)c3cccc(OC)c3n2)cc1";"Inhibition";"'='";"64.7";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4171219";"";"0";"450.58";"1";"5.57";"6b";"CCCOc1ccc(-c2cc(OCCN3CCCCC3)c3c(OC)cc(OC)cc3n2)cc1";"Inhibition";"'='";"49.7";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL141664";"";"0";"324.38";"0";"4.16";"14";"C=CCOc1ccc(C(=O)/C=C/c2cccc(OC)c2OC)cc1";"Inhibition";"";"";"";"";"";"tde";"";"";"";"";"";"False";"CHEMBL2162184";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL6966";"VERAPAMIL";"4";"454.61";"1";"5.09";"verapamil";"COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL2162181";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml after 150 to 160 secs by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL3417346";"";"0";"257.10";"None";"None";"3i";"OB(O)c1ccc(OCCCc2ccccc2)nc1";"Inhibition";"'='";"43.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3419438";"Inhibition of NorA in fluoroquinolone-resistant Staphylococcus aureus 1199B assessed as increase in ethidium bromide uptake at 20 ug/ml after 20 mins by fluorimetry relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3414455";"1";"Scientific Literature";"Eur. J. Med. Chem.";"2015";"None";""
"CHEMBL3417347";"";"0";"271.12";"None";"None";"3j";"OB(O)c1ccc(OCCCCc2ccccc2)nc1";"Inhibition";"'='";"42.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3419438";"Inhibition of NorA in fluoroquinolone-resistant Staphylococcus aureus 1199B assessed as increase in ethidium bromide uptake at 20 ug/ml after 20 mins by fluorimetry relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3414455";"1";"Scientific Literature";"Eur. J. Med. Chem.";"2015";"None";""
"CHEMBL4173927";"";"0";"309.37";"0";"4.40";"30";"CCCOc1ccc(-c2cc(O)c3ccc(OC)cc3n2)cc1";"Inhibition";"'='";"55.7";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4164737";"";"0";"408.54";"1";"5.42";"3a";"CCCOc1ccc(-c2cc(OCCN(CC)CC)c3cc(OC)ccc3n2)cc1";"Inhibition";"'='";"99.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4162146";"";"0";"309.37";"0";"4.40";"13";"CCCOc1ccc(-c2cc(O)c3c(OC)cccc3n2)cc1";"Inhibition";"'='";"91.4";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4170494";"";"0";"394.52";"1";"5.12";"8";"CCCOc1ccc(-c2cc(OCCN(CC)CC)c3cc(O)ccc3n2)cc1";"Inhibition";"'='";"95.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4155967";"Inhibition of Staphylococcus aureus SA-1199B NorA assessed as reduction in EtBr efflux at 50 uM measured over 5 mins by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4152305";"1";"Scientific Literature";"Eur J Med Chem";"2018";"None";""
"CHEMBL1650998";"";"0";"420.44";"0";"4.05";"30, specs codeAP-964/40915300";"CCOc1cc([C@@H]2C(C#N)=C(N)Oc3[nH]nc(C)c32)ccc1OCc1cccc(F)c1";"Inhibition";"'='";"4.9";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651162";"";"0";"378.52";"0";"4.80";"8";"CCCOc1ccc(-c2cc(=O)c3ccccc3n2CCN(CC)CC)cc1";"Inhibition";"'='";"57.3";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651195";"";"0";"455.58";"0";"3.37";"112";"CCOC(=O)c1cn(C2CC2)c2c(C)c(N3CCC4=C(C3)C(O)CCS4)c(N)cc2c1=O";"Inhibition";"'='";"47.3";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1650988";"";"0";"403.91";"1";"5.65";"20, specs codeAQ-360/41402277";"Cc1ccc(N2CCN(C3=Nc4cc(Cl)ccc4Oc4ccccc43)CC2)cc1";"Inhibition";"'='";"35.1";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL444726";"";"0";"283.40";"0";"4.70";"67";"CCCOc1ccc(C2=Nc3ccccc3SC2)cc1";"Inhibition";"'='";"84.5";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL444694";"";"0";"243.31";"0";"4.05";"69";"Fc1ccc(C2=Nc3ccccc3SC2)cc1";"Inhibition";"'='";"0.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL3774832";"";"0";"352.43";"0";"3.51";"33";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCN)cc12";"Inhibition";"'='";"67.7";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL3774853";"";"0";"448.61";"1";"5.82";"26";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCCN3CCCCCC3)cc12";"Inhibition";"'='";"77.4";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL3774928";"";"0";"361.36";"1";"5.19";"8";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(C(F)(F)F)cc12";"Inhibition";"'='";"36.6";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL3775857";"";"0";"502.58";"2";"6.45";"59";"CCOC(=O)c1c(C)n(Cc2cccc(C(F)(F)F)c2)c2ccc(OCCCN3CCCCC3)cc12";"Inhibition";"'='";"12.9";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL3775575";"";"0";"479.58";"1";"5.34";"62";"CCOC(=O)c1c(C)n(Cc2cccc([N+](=O)[O-])c2)c2ccc(OCCCN3CCCCC3)cc12";"Inhibition";"'='";"85.1";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL3775722";"";"0";"362.52";"1";"5.25";"73";"Cc1cc2cc(OCCCN3CCCCC3)ccc2n1Cc1ccccc1";"Inhibition";"'='";"95.6";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL1650986";"";"0";"295.30";"0";"4.00";"18, specs codeAG-690/11822559";"COc1ccccc1CNCc1cccc(C(F)(F)F)c1";"Inhibition";"'='";"30.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1650983";"";"0";"351.45";"0";"1.71";"13, specs codeAF-886/31411042";"CCOC(=O)C1SC(NC(=S)NC(=O)c2ccccc2)=NC1C";"Inhibition";"'='";"23.2";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651170";"";"0";"350.46";"0";"3.93";"85";"CCN(CC)CCOc1ccc(-c2cc(=O)c3ccccc3n2C)cc1";"Inhibition";"'='";"1.7";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651012";"";"0";"271.36";"0";"2.91";"47";"COc1cccc(CNC(C)C(O)c2ccccc2)c1";"Inhibition";"'='";"2.8";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL2158996";"";"0";"338.36";"0";"3.61";"7";"C=CCOc1ccccc1C(=O)/C=C/c1ccc(OCC(=O)O)cc1";"Inhibition";"";"";"";"";"";"tde";"";"";"";"";"";"False";"CHEMBL2162184";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL142493";"";"0";"284.31";"0";"3.31";"2";"COc1cccc(/C=C/C(=O)c2ccc(O)cc2)c1OC";"Inhibition";"";"";"";"";"";"tde";"";"";"";"";"";"False";"CHEMBL2162184";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL3775852";"";"0";"450.58";"0";"4.40";"37";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCC(O)CN3CCCCC3)cc12";"Inhibition";"'='";"99.3";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL1619158";"";"0";"466.58";"0";"3.02";"40, specs codeAI-020/37162014";"CCOC(=O)Nc1ccc2c(c1)N(C(=O)CCN1CCN(CCO)CC1)c1ccccc1CC2";"Inhibition";"'='";"0.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1478329";"";"0";"316.36";"0";"3.82";"41";"Cn1cccc1-c1nc2cc(NC(=O)c3ccccc3)ccc2[nH]1";"Inhibition";"'='";"88.4";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651016";"";"0";"414.49";"1";"5.17";"51";"CCOC(=O)CCSc1nc2c(c(C(F)(F)F)c1C#N)CC(C(C)(C)C)CC2";"Inhibition";"'='";"25.2";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651017";"";"0";"386.44";"0";"4.53";"52";"CCOC(=O)CCCSc1nc2c(c(C(F)(F)F)c1C#N)CC(C)CC2";"Inhibition";"'='";"48.6";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL4516749";"";"0";"347.84";"0";"3.45";"4";"COC(=O)[C@@H](NC(=O)/C=C/C1=C(Cl)c2ccccc2CC1)C(C)C";"Inhibition";"'='";"67.21";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4311538";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM measured after 5 mins by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4308903";"1";"Scientific Literature";"Bioorg Med Chem";"2019";"None";""
"CHEMBL3775445";"";"0";"421.54";"0";"3.46";"23";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCN3CCNCC3)cc12";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL3778150";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199 assessed as potentiation of ciprofloxacin-mediated antibacterial activity";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL481678";"";"0";"297.42";"1";"5.02";"8k";"CCCOc1ccc(C2=CSc3ccccc3N2C)cc1";"Inhibition";"'='";"0.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1015715";"Inhibition of NorA pump-mediated ethidium bromide efflux in Staphylococcus aureus K1199B at 50 uM by fluorimetric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1155078";"1";"Scientific Literature";"J. Med. Chem.";"2008";"None";""
"CHEMBL3774675";"";"0";"449.60";"0";"4.19";"28";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCCN3CCN(C)CC3)cc12";"Inhibition";"'='";"100.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL1651021";"";"0";"320.41";"0";"3.71";"57";"CCC(C)N1C(=O)S/C(=C\c2ccc(N3CCCC3)o2)C1=O";"Inhibition";"'='";"0.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651172";"";"0";"364.45";"0";"2.92";"22k";"Cn1c(-c2ccc(OCCN3CCOCC3)cc2)cc(=O)c2ccccc21";"Inhibition";"'='";"0.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1817147";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as inhibition of ethidium bromide efflux at 50 uM by fluorimetry";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1811797";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651180";"";"0";"378.52";"1";"5.41";"97";"CCCOc1ccc(-c2cc(OCCN(CC)CC)c3ccccc3n2)cc1";"Inhibition";"'='";"93.4";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651187";"";"0";"482.61";"0";"3.94";"104";"CCOC(=O)c1cn(C2CC2)c2cc(N3CCC4=C(C3)/C(=N/OC)C(C)CS4)c(N)cc2c1=O";"Inhibition";"'='";"19.7";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL3219951";"";"0";"436.53";"0";"0.84";"18";"CCOC(=O)C1(C)C(=O)c2cc(N)c(N3CCN(C)CC3)cc2N(C2CC2)S1(=O)=O";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL3226394";"Inhibition of NorA efflux pump in norA-overexpressing Staphylococcus aureus SA-K2378 assessed as reduction in ciprofloxacin MIC at 0.78 to 100 ug/ml by isobologram based checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3217728";"1";"Scientific Literature";"MedChemComm";"2012";"None";""
"CHEMBL4171147";"";"0";"558.68";"2";"6.16";"7d";"CCCOc1ccc(-c2cc(OCCN3CCc4cc(OC)c(OC)cc4C3)c3cc(OC)c(OC)cc3n2)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4151520";"Inhibition of NorA in Staphylococcus aureus SA-K2378 assessed as synergistic potentiation of ciprofloxacin-induced antimicrobial activity at 0.78 to 100 ug/ml by microdilution method based Checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4483762";"";"0";"357.41";"0";"2.93";"C6";"CCC(/C=C/C(=O)N1CCC[C@@H]1C(=O)OC)=C\c1ccc2c(c1)OCO2";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL4480154";"Inhibition of NorA efflux pump overexpressed in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux measured over 30 mins by fluorescence analysis";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4477264";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2016";"None";""
"CHEMBL490";"PAROXETINE";"4";"329.37";"0";"3.33";"paroxetine";"Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1";"Inhibition";"'='";"89.7";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL1817147";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as inhibition of ethidium bromide efflux at 50 uM by fluorimetry";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1811797";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL434066";"";"0";"284.31";"0";"3.31";"4";"COc1ccc(/C=C/C(=O)c2ccc(O)cc2)c(OC)c1";"Inhibition";"'='";"24.1";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2162041";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 5 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL1651003";"";"0";"480.59";"1";"5.34";"33, specs codeAH-487/15277106";"COc1cc(/C=C2\S/C(=N\c3ccccc3)N([C@@H]3CCCC[C@@H]3C)C2=O)ccc1OCC(=O)O";"Inhibition";"'='";"32.6";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651005";"";"0";"437.52";"0";"3.24";"36, specs codeAN-988/41721006";"Cc1ccc(N(CC(=O)Nc2ccc(C(N)=O)cc2)S(=O)(=O)c2ccccc2)cc1C";"Inhibition";"'='";"0.6";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL4161319";"";"0";"420.55";"1";"5.56";"2b";"CCCOc1ccc(-c2cc(OCCN3CCCCC3)c3c(OC)cccc3n2)cc1";"Inhibition";"'='";"83.4";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4167074";"";"0";"434.58";"1";"5.95";"4c";"CCCOc1ccc(-c2cc(OCCN3CCCCCC3)c3ccc(OC)cc3n2)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4151517";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as synergistic potentiation of ciprofloxacin-induced antimicrobial activity at 0.78 to 100 ug/ml by microdilution method based Checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4170066";"";"0";"558.68";"2";"6.16";"8d";"CCCOc1ccc(-c2cc(OCCN3CCc4cc(OC)c(OC)cc4C3)c3cc(OC)cc(OC)c3n2)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4151517";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as synergistic potentiation of ciprofloxacin-induced antimicrobial activity at 0.78 to 100 ug/ml by microdilution method based Checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4162139";"";"0";"420.55";"1";"5.56";"3b";"CCCOc1ccc(-c2cc(OCCN3CCCCC3)c3cc(OC)ccc3n2)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4151517";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as synergistic potentiation of ciprofloxacin-induced antimicrobial activity at 0.78 to 100 ug/ml by microdilution method based Checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL458207";"";"0";"502.50";"2";"5.05";"14";"CC1COc2c(NCc3ccc(NC(=O)Nc4ccccc4)cc3)c(F)cc3c(=O)c(C(=O)O)cn1c23";"Inhibition";"'='";"85.6";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1017716";"Inhibition of NorA efflux pump in Staphylococcus aureus K2361 assessed as reduction of ethidium bromide efflux at 2 uM for 5 mins";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1154468";"1";"Scientific Literature";"Eur. J. Med. Chem.";"2008";"None";""
"CHEMBL2385681";"";"0";"400.95";"1";"5.02";"3i";"CCCOc1ccc(-c2cc(OCCCN(C)C)c3ccccc3n2)cc1.Cl";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL2390107";"Inhibition of NorA in Staphylococcus aureus ATCC 25923 assessed as reduction of ciprofloxacin MIC at 0.78 to 100 ug/mL";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL4172372";"";"0";"408.54";"1";"5.42";"4a";"CCCOc1ccc(-c2cc(OCCN(CC)CC)c3ccc(OC)cc3n2)cc1";"Inhibition";"'='";"100.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4167074";"";"0";"434.58";"1";"5.95";"4c";"CCCOc1ccc(-c2cc(OCCN3CCCCCC3)c3ccc(OC)cc3n2)cc1";"Inhibition";"'='";"91.3";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL2158998";"";"0";"387.48";"1";"5.32";"9";"CN(C)CCOc1ccc(C(=O)/C=C/c2ccc(Oc3ccccc3)cc2)cc1";"Inhibition";"";"";"";"";"";"tde";"";"";"";"";"";"False";"CHEMBL2162184";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL1651174";"";"0";"311.34";"0";"2.93";"23c";"COc1cc2c(=O)cc(-c3ccc(O)cc3)n(C)c2cc1OC";"Inhibition";"'='";"0.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1817147";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as inhibition of ethidium bromide efflux at 50 uM by fluorimetry";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1811797";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL772";"RESERPINE";"4";"608.69";"1";"4.17";"Reserpine";"COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC";"Inhibition";"'='";"48.1";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2162041";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 5 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL2158997";"";"0";"313.37";"0";"3.66";"8";"CN(C)CCOc1ccc(C(=O)/C=C/c2ccccc2F)cc1";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL2162198";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL447756";"";"0";"338.31";"0";"4.84";"7j";"O=[N+]([O-])c1ccc(C2=Nc3cc(C(F)(F)F)ccc3SC2)cc1";"Inhibition";"'='";"69.7";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL1015715";"Inhibition of NorA pump-mediated ethidium bromide efflux in Staphylococcus aureus K1199B at 50 uM by fluorimetric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1155078";"1";"Scientific Literature";"J. Med. Chem.";"2008";"None";""
"CHEMBL2158999";"";"0";"338.45";"0";"3.59";"10";"CN(C)CCOc1ccc(C(=O)/C=C/c2ccc(N(C)C)cc2)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL2162181";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml after 150 to 160 secs by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL358518";"";"0";"284.31";"0";"3.31";"5";"COc1cc(O)cc(C)c1/C=C/C(=O)c1ccc(O)cc1";"Inhibition";"'='";"91.7";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2162179";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 20 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL4161465";"";"0";"434.58";"1";"5.95";"5c";"CCCOc1ccc(-c2cc(OCCN3CCCCCC3)c3cccc(OC)c3n2)cc1";"Inhibition";"'='";"72.8";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4163342";"";"0";"438.57";"1";"5.43";"6a";"CCCOc1ccc(-c2cc(OCCN(CC)CC)c3c(OC)cc(OC)cc3n2)cc1";"Inhibition";"'='";"93.1";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4167087";"";"0";"505.70";"2";"6.28";"11a";"CCCOc1ccc(-c2cc(OCCN3CCCCC3)c3cc(OCCN(CC)CC)ccc3n2)cc1";"Inhibition";"'='";"91.4";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4155967";"Inhibition of Staphylococcus aureus SA-1199B NorA assessed as reduction in EtBr efflux at 50 uM measured over 5 mins by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4152305";"1";"Scientific Literature";"Eur J Med Chem";"2018";"None";""
"CHEMBL4176162";"";"0";"394.52";"1";"5.03";"4e";"CCCOc1ccc(-c2cc(OCCCN(C)C)c3ccc(OC)cc3n2)cc1";"Inhibition";"'='";"100.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4163206";"";"0";"335.40";"1";"5.22";"21";"C=COc1cc(-c2ccc(OCCC)cc2)nc2c(OC)cccc12";"Inhibition";"'='";"13.3";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL142493";"";"0";"284.31";"0";"3.31";"2";"COc1cccc(/C=C/C(=O)c2ccc(O)cc2)c1OC";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL2162181";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml after 150 to 160 secs by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL481947";"";"0";"225.32";"0";"3.91";"7";"c1ccc(C2=Nc3ccccc3SC2)cc1";"Inhibition";"'='";"0.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL2048634";"";"0";"489.91";"1";"6.02";"4d";"CN1c2c(-c3ccc(Cl)cc3)nn(-c3cccc(C(F)(F)F)c3)c2-c2ccccc2S1(=O)=O";"Inhibition";"'='";"0.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2051680";"Inhibition of norA-mediated EtBr efflux in Staphylococcus aureus SA1199B overexpressing norA and expressing A116E GrlA mutation at 50 uM by fluorometry";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2046274";"1";"Scientific Literature";"J. Med. Chem.";"2012";"None";""
"CHEMBL1651177";"";"0";"267.28";"0";"2.62";"26a";"Cn1c(-c2ccccc2)cc(=O)c2cc(O)c(O)cc21";"Inhibition";"'='";"0.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1817147";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as inhibition of ethidium bromide efflux at 50 uM by fluorimetry";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1811797";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651180";"";"0";"378.52";"1";"5.41";"28f";"CCCOc1ccc(-c2cc(OCCN(CC)CC)c3ccccc3n2)cc1";"Inhibition";"'='";"93.4";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL1817147";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as inhibition of ethidium bromide efflux at 50 uM by fluorimetry";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1811797";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL2158998";"";"0";"387.48";"1";"5.32";"9";"CN(C)CCOc1ccc(C(=O)/C=C/c2ccc(Oc3ccccc3)cc2)cc1";"Inhibition";"'='";"43.4";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2162040";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 2.5 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL358518";"";"0";"284.31";"0";"3.31";"5";"COc1cc(O)cc(C)c1/C=C/C(=O)c1ccc(O)cc1";"Inhibition";"'='";"36.6";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2162040";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 2.5 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL144721";"";"0";"298.34";"0";"3.61";"15";"COc1ccc(/C=C/C(=O)c2ccccc2OC)c(OC)c1";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL2162198";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL445589";"";"0";"257.36";"0";"3.95";"15d";"COc1ccc(C2CSc3ccccc3N2)cc1";"Inhibition";"'='";"10.4";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL1015715";"Inhibition of NorA pump-mediated ethidium bromide efflux in Staphylococcus aureus K1199B at 50 uM by fluorimetric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1155078";"1";"Scientific Literature";"J. Med. Chem.";"2008";"None";""
"CHEMBL1492652";"";"0";"366.45";"0";"3.68";"16, specs codeAE-848/42434549";"Cc1ccc(S(=O)(=O)Nc2ccc3[nH]c(-c4cccn4C)nc3c2)cc1";"Inhibition";"'='";"88.2";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1429416";"";"0";"292.34";"0";"3.17";"15, specs codeAE-406/41056622";"CCc1c(O)cc(-c2cccnc2)n(-c2ccccc2)c1=O";"Inhibition";"'='";"30.7";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651192";"";"0";"482.61";"0";"4.08";"109";"CCOC(=O)c1cn(C2CC2)c2c(C)c(N3CCC4=C(C3)/C(=N/O)C(C)CS4)c(N)cc2c1=O";"Inhibition";"'='";"90.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651167";"";"0";"293.37";"0";"3.99";"82";"CCCOc1ccc(-c2cc(=O)c3ccccc3n2C)cc1";"Inhibition";"'='";"3.9";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651018";"";"0";"363.78";"0";"3.96";"54";"CN1C(=O)S/C(=C/c2ccc(-c3cc(C(=O)O)ccc3Cl)o2)C1=O";"Inhibition";"'='";"20.9";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL444726";"";"0";"283.40";"0";"4.70";"6k";"CCCOc1ccc(C2=Nc3ccccc3SC2)cc1";"Inhibition";"'='";"84.7";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL1015715";"Inhibition of NorA pump-mediated ethidium bromide efflux in Staphylococcus aureus K1199B at 50 uM by fluorimetric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1155078";"1";"Scientific Literature";"J. Med. Chem.";"2008";"None";""
"CHEMBL480007";"";"0";"285.37";"0";"3.93";"6g";"COc1ccc(C2=Nc3ccccc3SC2)cc1OC";"Inhibition";"'='";"22.8";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL1015715";"Inhibition of NorA pump-mediated ethidium bromide efflux in Staphylococcus aureus K1199B at 50 uM by fluorimetric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1155078";"1";"Scientific Literature";"J. Med. Chem.";"2008";"None";""
"CHEMBL481679";"";"0";"273.43";"0";"4.67";"15m";"CSc1ccc(C2CSc3ccccc3N2)cc1";"Inhibition";"'='";"28.2";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL1015715";"Inhibition of NorA pump-mediated ethidium bromide efflux in Staphylococcus aureus K1199B at 50 uM by fluorimetric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1155078";"1";"Scientific Literature";"J. Med. Chem.";"2008";"None";""
"CHEMBL445549";"";"0";"270.31";"0";"3.82";"6j";"O=[N+]([O-])c1ccc(C2=Nc3ccccc3SC2)cc1";"Inhibition";"'='";"19.6";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL1015715";"Inhibition of NorA pump-mediated ethidium bromide efflux in Staphylococcus aureus K1199B at 50 uM by fluorimetric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1155078";"1";"Scientific Literature";"J. Med. Chem.";"2008";"None";""
"CHEMBL90145";"";"0";"280.32";"0";"4.25";"4";"CCCOc1ccc(-c2cc(=O)c3ccccc3o2)cc1";"Inhibition";"'='";"32.4";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1817147";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as inhibition of ethidium bromide efflux at 50 uM by fluorimetry";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1811797";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651180";"";"0";"378.52";"1";"5.41";"1";"CCCOc1ccc(-c2cc(OCCN(CC)CC)c3ccccc3n2)cc1";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL2390106";"Inhibition of wild type NorA in Staphylococcus aureus 1199 assessed as reduction of ciprofloxacin MIC at 0.78 to 100 ug/mL";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL2385668";"";"0";"404.51";"0";"4.73";"3z";"CCCOc1ccc(-c2cc(OCCN3CCC(=O)CC3)c3ccccc3n2)cc1";"Inhibition";"'='";"71.7";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2390114";"Inhibition of NorA in Staphylococcus aureus 1199B harboring grlA A116E mutant assessed as inhibition of ethidium bromide efflux at 50 uM measured for 5 mins by fluorometric analysis relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL2158999";"";"0";"338.45";"0";"3.59";"10";"CN(C)CCOc1ccc(C(=O)/C=C/c2ccc(N(C)C)cc2)cc1";"Inhibition";"'='";"98.7";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2162179";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 20 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL354676";"DIPHENYLUREA";"0";"212.25";"0";"3.33";"27";"O=C(Nc1ccccc1)Nc1ccccc1";"Inhibition";"'='";"20.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1017717";"Inhibition of NorA efflux pump in Staphylococcus aureus K2361 assessed as reduction of ethidium bromide efflux at 0.5 uM for 5 mins";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1154468";"1";"Scientific Literature";"Eur. J. Med. Chem.";"2008";"None";""
"CHEMBL772";"RESERPINE";"4";"608.69";"1";"4.17";"Reserpine";"COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4311549";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide accumulation at 25 uM measured at 5 mins interval for 60 mins by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4308903";"1";"Scientific Literature";"Bioorg Med Chem";"2019";"None";""
"CHEMBL1112";"ARIPIPRAZOLE";"4";"448.39";"0";"4.86";"7";"O=C1CCc2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2N1";"Inhibition";"'='";"92.3";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2049765";"Inhibition of norA-mediated ethidium bromide efflux in Staphylococcus aureus SA-1199B harboring grlA A116E mutant at 50 uM after 5 mins by fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2046272";"1";"Scientific Literature";"ACS Med. Chem. Lett.";"2012";"None";""
"CHEMBL939";"GEFITINIB";"4";"446.91";"0";"4.28";"74";"COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1";"Inhibition";"'='";"94.2";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4043389";"Inhibition of NorA in Staphylococcus aureus SA1199B harboring GrlA A116E mutant assessed as inhibition of ethidium bromide efflux at 50 uM measured after 5 mins by fluorometric method relative to control";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4043064";"1";"Scientific Literature";"J Med Chem";"2017";"None";""
"CHEMBL490";"PAROXETINE";"4";"329.37";"0";"3.33";"Paroxetine";"Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1";"Inhibition";"'='";"90.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3226388";"Inhibition of NorA efflux pump in Staphylococcus aureus SA-1199B assessed as inhibition of EtBr efflux at 50 uM";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3217728";"1";"Scientific Literature";"MedChemComm";"2012";"None";""
"CHEMBL2158993";"";"0";"385.46";"0";"3.55";"20";"COc1ccc(C(=O)/C=C/c2cccc(OCCN(C)C)c2)c(OC)c1OC";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL2162185";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 10 uM by spectrofluorometric analysis in absence of Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL145666";"";"0";"314.34";"0";"3.31";"16";"COc1cc(OC)c(/C=C/C(=O)c2ccc(O)cc2)c(OC)c1";"Inhibition";"";"";"";"";"";"tde";"";"";"";"";"";"False";"CHEMBL2162184";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL144721";"";"0";"298.34";"0";"3.61";"15";"COc1ccc(/C=C/C(=O)c2ccccc2OC)c(OC)c1";"Inhibition";"";"";"";"";"";"tde";"";"";"";"";"";"False";"CHEMBL2162184";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL2158996";"";"0";"338.36";"0";"3.61";"7";"C=CCOc1ccccc1C(=O)/C=C/c1ccc(OCC(=O)O)cc1";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL2162038";"Inhibition of norA in Staphylococcus aureus SA-1199B overexpressing norA assessed as fold reduction in ciprofloxacin MIC by checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL2158994";"";"0";"295.38";"0";"3.52";"1";"CN(C)CCOc1ccc(C(=O)/C=C/c2ccccc2)cc1";"Inhibition";"'='";"83.6";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2162179";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 20 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL772";"RESERPINE";"4";"608.69";"1";"4.17";"Reserpine";"COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC";"Inhibition";"'='";"71.8";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2162042";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 10 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL2158997";"";"0";"313.37";"0";"3.66";"8";"CN(C)CCOc1ccc(C(=O)/C=C/c2ccccc2F)cc1";"Inhibition";"'='";"33.7";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2162040";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 2.5 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL2385685";"";"0";"438.57";"1";"6.13";"3n";"CCCOc1ccc(-c2cc(OCCN3CCc4ccccc4C3)c3ccccc3n2)cc1";"Inhibition";"'='";"67.9";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2390114";"Inhibition of NorA in Staphylococcus aureus 1199B harboring grlA A116E mutant assessed as inhibition of ethidium bromide efflux at 50 uM measured for 5 mins by fluorometric analysis relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL772";"RESERPINE";"4";"608.69";"1";"4.17";"Reserpine";"COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4151520";"Inhibition of NorA in Staphylococcus aureus SA-K2378 assessed as synergistic potentiation of ciprofloxacin-induced antimicrobial activity at 0.78 to 100 ug/ml by microdilution method based Checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL296419";"ASTEMIZOLE";"4";"458.58";"1";"5.35";"Astemizole";"COc1ccc(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1";"Inhibition";"'='";"81.1";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2390114";"Inhibition of NorA in Staphylococcus aureus 1199B harboring grlA A116E mutant assessed as inhibition of ethidium bromide efflux at 50 uM measured for 5 mins by fluorometric analysis relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL1650982";"";"0";"329.36";"0";"0.22";"12, specs codeAP-906/42288162";"NS(=O)(=O)c1ccc(NC2=NC(=O)C(CC(=O)O)S2)cc1";"Inhibition";"'='";"0.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL71";"CHLORPROMAZINE";"4";"318.87";"0";"4.89";"5";"CN(C)CCCN1c2ccccc2Sc2ccc(Cl)cc21";"Inhibition";"'='";"76.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1087296";"TRICHOSTACHINE";"0";"271.32";"0";"2.61";"Piperine";"O=C(/C=C/C=C/c1ccc2c(c1)OCO2)N1CCCC1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4311549";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide accumulation at 25 uM measured at 5 mins interval for 60 mins by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4308903";"1";"Scientific Literature";"Bioorg Med Chem";"2019";"None";""
"CHEMBL1651181";"";"0";"390.53";"1";"5.56";"29f";"CCCOc1ccc(-c2cc(OCCN3CCCCC3)c3ccccc3n2)cc1";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL1817275";"Inhibition of wild-type norA expressing Staphylococcus aureus 1199 assessed as reduction in ciprofloxacin MIC";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1811797";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL3775390";"";"0";"470.56";"1";"5.67";"45";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCCN3CCC(F)(F)CC3)cc12";"Inhibition";"'='";"25.9";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL3775173";"";"0";"479.58";"1";"5.34";"61";"CCOC(=O)c1c(C)n(Cc2ccccc2[N+](=O)[O-])c2ccc(OCCCN3CCCCC3)cc12";"Inhibition";"'='";"91.8";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL3775819";"";"0";"479.58";"1";"5.34";"63";"CCOC(=O)c1c(C)n(Cc2ccc([N+](=O)[O-])cc2)c2ccc(OCCCN3CCCCC3)cc12";"Inhibition";"'='";"89.9";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL3774716";"";"0";"381.47";"0";"4.32";"13";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCC(O)CC)cc12";"Inhibition";"'='";"71.1";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL3775445";"";"0";"421.54";"0";"3.46";"23";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCN3CCNCC3)cc12";"Inhibition";"'='";"99.2";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL4530442";"";"0";"411.89";"0";"3.75";"8";"COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)/C=C/C1=C(Cl)c2ccccc2CC1";"Inhibition";"'>'";"80.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4311546";"Inhibition of NorA Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 6.25 to 50 uM measured at 5 mins interval for 30 mins by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4308903";"1";"Scientific Literature";"Bioorg Med Chem";"2019";"None";""
"CHEMBL1651013";"";"0";"406.43";"1";"5.23";"48";"N#Cc1c(SCc2ccc(C(=O)O)cc2)nc2c(c1C(F)(F)F)CCCCC2";"Inhibition";"'='";"67.1";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL3947018";"";"0";"631.82";"2";"7.31";"9";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCN3CCN(CCCOc4ccccc4-c4ccccc4)CC3)cc12";"Inhibition";"'='";"27.1";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3879153";"Inhibition of Staphylococcus aureus 1199B NorA assessed as inhibition of ethidium bromide efflux at 50 uM measured after 5 mins by fluorometric method relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3877305";"1";"Scientific Literature";"J Med Chem";"2017";"None";""
"CHEMBL3963526";"";"0";"617.79";"2";"6.92";"8";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCN3CCN(CCOc4ccccc4-c4ccccc4)CC3)cc12";"Inhibition";"'='";"24.3";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3879153";"Inhibition of Staphylococcus aureus 1199B NorA assessed as inhibition of ethidium bromide efflux at 50 uM measured after 5 mins by fluorometric method relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3877305";"1";"Scientific Literature";"J Med Chem";"2017";"None";""
"CHEMBL2159000";"";"0";"388.42";"0";"4.82";"11";"COc1cc(/C=C/C(=O)c2cccc(OC(=O)c3ccccc3)c2)cc(OC)c1";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL2162198";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL2158998";"";"0";"387.48";"1";"5.32";"9";"CN(C)CCOc1ccc(C(=O)/C=C/c2ccc(Oc3ccccc3)cc2)cc1";"Inhibition";"'='";"97.5";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2162042";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 10 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL422481";"";"0";"284.31";"0";"3.31";"6";"COc1ccc(OC)c(/C=C/C(=O)c2ccc(O)cc2)c1";"Inhibition";"'='";"82.7";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2162042";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 10 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL2158997";"";"0";"313.37";"0";"3.66";"8";"CN(C)CCOc1ccc(C(=O)/C=C/c2ccccc2F)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL2162181";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml after 150 to 160 secs by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL2158996";"";"0";"338.36";"0";"3.61";"7";"C=CCOc1ccccc1C(=O)/C=C/c1ccc(OCC(=O)O)cc1";"Inhibition";"'='";"46.2";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2162041";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 5 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL142493";"";"0";"284.31";"0";"3.31";"2";"COc1cccc(/C=C/C(=O)c2ccc(O)cc2)c1OC";"Inhibition";"'='";"38.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2162041";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 5 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL118";"CELECOXIB";"4";"381.38";"0";"3.51";"Celecoxib";"Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL2051686";"Inhibition of norA in wild type Staphylococcus aureus SA1199 expressing assessed as potentiation of ciprofloxacin MIC by checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2046274";"1";"Scientific Literature";"J. Med. Chem.";"2012";"None";""
"CHEMBL490";"PAROXETINE";"4";"329.37";"0";"3.33";"paroxetine";"Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL2051687";"Inhibition of norA overexpressed in Staphylococcus aureus SA1199B coexpressing A116E GrlA mutation assessed as potentiation of ciprofloxacin MIC by checkerboard assay";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2046274";"1";"Scientific Literature";"J. Med. Chem.";"2012";"None";""
"CHEMBL1651164";"";"0";"296.39";"0";"4.72";"6";"CCCOc1ccc(-c2cc(=O)c3ccccc3s2)cc1";"Inhibition";"'='";"6.3";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1817147";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as inhibition of ethidium bromide efflux at 50 uM by fluorimetry";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1811797";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL772";"RESERPINE";"4";"608.69";"1";"4.17";"14";"COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4043397";"Inhibition of Staphylococcus aureus SAK2378 norA assessed as potentiation of CPX-induced antimicrobial activity up to 100 ug/ml by checkerboard assay";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4043064";"1";"Scientific Literature";"J Med Chem";"2017";"None";""
"CHEMBL490";"PAROXETINE";"4";"329.37";"0";"3.33";"paroxetine";"Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL1817275";"Inhibition of wild-type norA expressing Staphylococcus aureus 1199 assessed as reduction in ciprofloxacin MIC";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1811797";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL3976297";"";"0";"631.82";"2";"7.31";"10";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCCN3CCN(CCOc4cccc(-c5ccccc5)c4)CC3)cc12";"Inhibition";"'='";"23.9";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3879153";"Inhibition of Staphylococcus aureus 1199B NorA assessed as inhibition of ethidium bromide efflux at 50 uM measured after 5 mins by fluorometric method relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3877305";"1";"Scientific Literature";"J Med Chem";"2017";"None";""
"CHEMBL1617533";"";"0";"354.49";"0";"3.12";"4";"OCCCN1CCN(CCCOc2ccccc2-c2ccccc2)CC1";"Inhibition";"'<'";"10.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3879153";"Inhibition of Staphylococcus aureus 1199B NorA assessed as inhibition of ethidium bromide efflux at 50 uM measured after 5 mins by fluorometric method relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3877305";"1";"Scientific Literature";"J Med Chem";"2017";"None";""
"CHEMBL318551";"";"0";"311.43";"0";"3.81";"3";"COc1ccc(OC[C@@H]2CN(C)CC[C@H]2c2ccccc2)cc1";"Inhibition";"'='";"50.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1650996";"";"0";"405.86";"1";"5.13";"28, specs codeAH-487/41139966";"CC[C@H](C)N1C(=O)S/C(=C/c2ccc(-c3cc(C(=O)O)ccc3Cl)o2)C1=O";"Inhibition";"'='";"81.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL2048631";"";"0";"486.96";"0";"3.62";"3f";"NS(=O)(=O)c1ccc(-n2nc(-c3ccc(Cl)cc3)c3c2-c2ccccc2S(=O)(=O)N3)cc1";"Inhibition";"'='";"29.8";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2051680";"Inhibition of norA-mediated EtBr efflux in Staphylococcus aureus SA1199B overexpressing norA and expressing A116E GrlA mutation at 50 uM by fluorometry";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2046274";"1";"Scientific Literature";"J. Med. Chem.";"2012";"None";""
"CHEMBL3219950";"";"0";"364.47";"0";"0.90";"17";"CC1C(=O)c2cc(N)c(N3CCN(C)CC3)cc2N(C2CC2)S1(=O)=O";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL3226394";"Inhibition of NorA efflux pump in norA-overexpressing Staphylococcus aureus SA-K2378 assessed as reduction in ciprofloxacin MIC at 0.78 to 100 ug/ml by isobologram based checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3217728";"1";"Scientific Literature";"MedChemComm";"2012";"None";""
"CHEMBL4174957";"";"0";"528.65";"2";"6.15";"4d";"CCCOc1ccc(-c2cc(OCCN3CCc4cc(OC)c(OC)cc4C3)c3ccc(OC)cc3n2)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4151518";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as synergistic potentiation of ciprofloxacin-induced antimicrobial activity at 0.78 ug/ml by microdilution method based Checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL2385687";"";"0";"408.57";"1";"5.12";"3p";"CCCOc1ccc(-c2cc(OCCN3CCSCC3)c3ccccc3n2)cc1";"Inhibition";"'='";"57.7";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2390114";"Inhibition of NorA in Staphylococcus aureus 1199B harboring grlA A116E mutant assessed as inhibition of ethidium bromide efflux at 50 uM measured for 5 mins by fluorometric analysis relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL3219950";"";"0";"364.47";"0";"0.90";"17";"CC1C(=O)c2cc(N)c(N3CCN(C)CC3)cc2N(C2CC2)S1(=O)=O";"Inhibition";"'='";"27.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3226388";"Inhibition of NorA efflux pump in Staphylococcus aureus SA-1199B assessed as inhibition of EtBr efflux at 50 uM";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3217728";"1";"Scientific Literature";"MedChemComm";"2012";"None";""
"CHEMBL772";"RESERPINE";"4";"608.69";"1";"4.17";"Reserpine";"COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL2051687";"Inhibition of norA overexpressed in Staphylococcus aureus SA1199B coexpressing A116E GrlA mutation assessed as potentiation of ciprofloxacin MIC by checkerboard assay";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2046274";"1";"Scientific Literature";"J. Med. Chem.";"2012";"None";""
"CHEMBL118";"CELECOXIB";"4";"381.38";"0";"3.51";"7 Celecoxib";"Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL2051690";"Inhibition of norA overexpressed in Staphylococcus aureus SA1199B coexpressing A116E GrlA mutation potentiation of EtBr MIC at >6.25 ug/mL by checkerboard assay";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2046274";"1";"Scientific Literature";"J. Med. Chem.";"2012";"None";""
"CHEMBL458207";"";"0";"502.50";"2";"5.05";"14";"CC1COc2c(NCc3ccc(NC(=O)Nc4ccccc4)cc3)c(F)cc3c(=O)c(C(=O)O)cn1c23";"Inhibition";"'='";"73.6";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1017717";"Inhibition of NorA efflux pump in Staphylococcus aureus K2361 assessed as reduction of ethidium bromide efflux at 0.5 uM for 5 mins";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1154468";"1";"Scientific Literature";"Eur. J. Med. Chem.";"2008";"None";""
"CHEMBL4162139";"";"0";"420.55";"1";"5.56";"3b";"CCCOc1ccc(-c2cc(OCCN3CCCCC3)c3cc(OC)ccc3n2)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4151520";"Inhibition of NorA in Staphylococcus aureus SA-K2378 assessed as synergistic potentiation of ciprofloxacin-induced antimicrobial activity at 0.78 to 100 ug/ml by microdilution method based Checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4171010";"";"0";"498.62";"1";"6.63";"6";"CCCOc1ccc(-c2cc(OCCN(CC)CC)c3cc(OC(=O)c4ccccc4)ccc3n2)cc1";"Inhibition";"'='";"91.1";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4155967";"Inhibition of Staphylococcus aureus SA-1199B NorA assessed as reduction in EtBr efflux at 50 uM measured over 5 mins by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4152305";"1";"Scientific Literature";"Eur J Med Chem";"2018";"None";""
"CHEMBL4467715";"";"0";"333.82";"0";"3.21";"9";"COC(=O)CCCNC(=O)/C=C/C1=C(Cl)c2ccccc2CC1";"Inhibition";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL4311538";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM measured after 5 mins by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4308903";"1";"Scientific Literature";"Bioorg Med Chem";"2019";"None";""
"CHEMBL4530442";"";"0";"411.89";"0";"3.75";"8";"COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)/C=C/C1=C(Cl)c2ccccc2CC1";"Inhibition";"'='";"85.24";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4311539";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM measured over 5 mins interval for 30 mins by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4308903";"1";"Scientific Literature";"Bioorg Med Chem";"2019";"None";""
"CHEMBL358518";"";"0";"284.31";"0";"3.31";"5";"COc1cc(O)cc(C)c1/C=C/C(=O)c1ccc(O)cc1";"Inhibition";"'='";"84.3";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2162042";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 10 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL142493";"";"0";"284.31";"0";"3.31";"2";"COc1cccc(/C=C/C(=O)c2ccc(O)cc2)c1OC";"Inhibition";"'='";"73.3";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2162042";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 10 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL3775322";"";"0";"420.55";"1";"5.04";"21";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCN3CCCCC3)cc12";"Inhibition";"'='";"100.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL3775062";"";"0";"435.57";"0";"3.85";"29";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCCN3CCNCC3)cc12";"Inhibition";"'='";"100.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL3775841";"";"0";"366.46";"0";"3.90";"34";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCCN)cc12";"Inhibition";"'='";"100.0";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL3774995";"";"0";"464.61";"0";"4.79";"38";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCC(O)CN3CCCCCC3)cc12";"Inhibition";"'='";"92.8";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL1651180";"";"0";"378.52";"1";"5.41";"1";"CCCOc1ccc(-c2cc(OCCN(CC)CC)c3ccccc3n2)cc1";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL2390107";"Inhibition of NorA in Staphylococcus aureus ATCC 25923 assessed as reduction of ciprofloxacin MIC at 0.78 to 100 ug/mL";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL2385678";"";"0";"376.50";"1";"5.16";"3f";"CCCOc1ccc(-c2cc(OC3CCCN(C)C3)c3ccccc3n2)cc1";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL2390107";"Inhibition of NorA in Staphylococcus aureus ATCC 25923 assessed as reduction of ciprofloxacin MIC at 0.78 to 100 ug/mL";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL434066";"";"0";"284.31";"0";"3.31";"4";"COc1ccc(/C=C/C(=O)c2ccc(O)cc2)c(OC)c1";"Inhibition";"'='";"62.7";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2162042";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 10 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL2158998";"";"0";"387.48";"1";"5.32";"9";"CN(C)CCOc1ccc(C(=O)/C=C/c2ccc(Oc3ccccc3)cc2)cc1";"Inhibition";"'='";"68.8";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2162041";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 5 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL1651015";"";"0";"383.83";"1";"5.19";"50";"N#Cc1c(SCc2ccc(Cl)nc2)nc2c(c1C(F)(F)F)CCCC2";"Inhibition";"'='";"41.3";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL4165585";"";"0";"371.86";"1";"5.32";"20";"CCCOc1ccc(-c2cc(OCCCl)c3cccc(OC)c3n2)cc1";"Inhibition";"'='";"6.8";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4169390";"";"0";"420.55";"1";"5.56";"5b";"CCCOc1ccc(-c2cc(OCCN3CCCCC3)c3cccc(OC)c3n2)cc1";"Inhibition";"'='";"88.7";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4173506";"";"0";"394.52";"1";"5.03";"3e";"CCCOc1ccc(-c2cc(OCCCN(C)C)c3cc(OC)ccc3n2)cc1";"Inhibition";"'='";"79.5";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4539308";"";"0";"434.92";"0";"4.52";"7";"COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)/C=C/C1=C(Cl)c2ccccc2CC1";"Inhibition";"'>'";"80.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4311546";"Inhibition of NorA Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 6.25 to 50 uM measured at 5 mins interval for 30 mins by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4308903";"1";"Scientific Literature";"Bioorg Med Chem";"2019";"None";""
"CHEMBL4168315";"";"0";"511.67";"2";"5.90";"4f";"CCCOc1ccc(-c2cc(OCCN3CCN(Cc4ccccc4)CC3)c3ccc(OC)cc3n2)cc1";"Inhibition";"'='";"92.1";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4175717";"";"0";"438.57";"1";"5.43";"7a";"CCCOc1ccc(-c2cc(OCCN(CC)CC)c3cc(OC)c(OC)cc3n2)cc1";"Inhibition";"'='";"95.4";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL3219739";"";"0";"407.50";"0";"0.31";"10";"CNC(=O)C1=C(O)c2cc(N)c(N3CCN(C)CC3)cc2N(C2CC2)S1(=O)=O";"Inhibition";"'='";"2.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3226388";"Inhibition of NorA efflux pump in Staphylococcus aureus SA-1199B assessed as inhibition of EtBr efflux at 50 uM";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3217728";"1";"Scientific Literature";"MedChemComm";"2012";"None";""
"CHEMBL2048629";"";"0";"425.87";"1";"5.11";"3b";"O=S1(=O)Nc2c(-c3ccc(Cl)cc3)nn(-c3cccc(F)c3)c2-c2ccccc21";"Inhibition";"'='";"33.9";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2051680";"Inhibition of norA-mediated EtBr efflux in Staphylococcus aureus SA1199B overexpressing norA and expressing A116E GrlA mutation at 50 uM by fluorometry";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2046274";"1";"Scientific Literature";"J. Med. Chem.";"2012";"None";""
"CHEMBL772";"RESERPINE";"4";"608.69";"1";"4.17";"Reserpine";"COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC";"Inhibition";"'='";"84.8";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL2051680";"Inhibition of norA-mediated EtBr efflux in Staphylococcus aureus SA1199B overexpressing norA and expressing A116E GrlA mutation at 50 uM by fluorometry";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2046274";"1";"Scientific Literature";"J. Med. Chem.";"2012";"None";""
"CHEMBL2385684";"";"0";"404.55";"1";"5.95";"3m";"CCCOc1ccc(-c2cc(OCCN3CCCCCC3)c3ccccc3n2)cc1";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL2390106";"Inhibition of wild type NorA in Staphylococcus aureus 1199 assessed as reduction of ciprofloxacin MIC at 0.78 to 100 ug/mL";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL4175717";"";"0";"438.57";"1";"5.43";"7a";"CCCOc1ccc(-c2cc(OCCN(CC)CC)c3cc(OC)c(OC)cc3n2)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4151517";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as synergistic potentiation of ciprofloxacin-induced antimicrobial activity at 0.78 to 100 ug/ml by microdilution method based Checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL1651181";"";"0";"390.53";"1";"5.56";"98";"CCCOc1ccc(-c2cc(OCCN3CCCCC3)c3ccccc3n2)cc1";"Inhibition";"'='";"88.5";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL12089";"BERBERINE CHLORIDE";"1";"371.82";"0";"3.10";"Berberine";"COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2.[Cl-]";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL1638729";"Inhibition of NorA in Staphylococcus aureus K2378 overexpressing NorA assessed as accumulation of compound at 3 uM by fluorescence assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1629702";"1";"Scientific Literature";"Antimicrob. Agents Chemother.";"2010";"None";""
"CHEMBL1651019";"";"0";"405.86";"1";"5.13";"55";"CCC(C)N1C(=O)S/C(=C\c2ccc(-c3cc(C(=O)O)ccc3Cl)o2)C1=O";"Inhibition";"'='";"74.7";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL772";"RESERPINE";"4";"608.69";"1";"4.17";"1";"COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC";"Inhibition";"'='";"84.8";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL4171241";"";"0";"421.54";"0";"3.98";"5g";"CCCOc1ccc(-c2cc(OCCN3CCNCC3)c3cccc(OC)c3n2)cc1";"Inhibition";"'='";"100.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL1651171";"";"0";"322.41";"0";"3.15";"86";"CN(C)CCOc1ccc(-c2cc(=O)c3ccccc3n2C)cc1";"Inhibition";"'='";"4.4";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651178";"";"0";"283.28";"0";"2.32";"93";"Cn1c(-c2ccc(O)cc2)cc(=O)c2cc(O)c(O)cc21";"Inhibition";"'='";"0.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651190";"";"0";"467.59";"0";"3.82";"107";"CCOC(=O)c1cn(C2CC2)c2c(C)c(N3CCC4=C(C3)C(=O)C(C)CS4)c(N)cc2c1=O";"Inhibition";"'='";"50.5";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651172";"";"0";"364.45";"0";"2.92";"87";"Cn1c(-c2ccc(OCCN3CCOCC3)cc2)cc(=O)c2ccccc21";"Inhibition";"'='";"0.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL4175014";"";"0";"558.68";"2";"6.16";"6d";"CCCOc1ccc(-c2cc(OCCN3CCc4cc(OC)c(OC)cc4C3)c3c(OC)cc(OC)cc3n2)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4151520";"Inhibition of NorA in Staphylococcus aureus SA-K2378 assessed as synergistic potentiation of ciprofloxacin-induced antimicrobial activity at 0.78 to 100 ug/ml by microdilution method based Checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4168471";"";"0";"521.70";"2";"5.51";"10c";"CCCOc1ccc(-c2cc(OCCN(CC)CC)c3cc(OCCCN4CCOCC4)ccc3n2)cc1";"Inhibition";"'='";"91.1";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4155967";"Inhibition of Staphylococcus aureus SA-1199B NorA assessed as reduction in EtBr efflux at 50 uM measured over 5 mins by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4152305";"1";"Scientific Literature";"Eur J Med Chem";"2018";"None";""
"CHEMBL2385682";"";"0";"392.50";"0";"4.40";"3k";"CCCOc1ccc(-c2cc(OCCN3CCOCC3)c3ccccc3n2)cc1";"Inhibition";"'='";"86.9";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2390114";"Inhibition of NorA in Staphylococcus aureus 1199B harboring grlA A116E mutant assessed as inhibition of ethidium bromide efflux at 50 uM measured for 5 mins by fluorometric analysis relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL772";"RESERPINE";"4";"608.69";"1";"4.17";"Reserpine";"COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC";"Inhibition";"'='";"82.0";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL2390114";"Inhibition of NorA in Staphylococcus aureus 1199B harboring grlA A116E mutant assessed as inhibition of ethidium bromide efflux at 50 uM measured for 5 mins by fluorometric analysis relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL772";"RESERPINE";"4";"608.69";"1";"4.17";"Reserpine";"COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL3226394";"Inhibition of NorA efflux pump in norA-overexpressing Staphylococcus aureus SA-K2378 assessed as reduction in ciprofloxacin MIC at 0.78 to 100 ug/ml by isobologram based checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3217728";"1";"Scientific Literature";"MedChemComm";"2012";"None";""
"CHEMBL490";"PAROXETINE";"4";"329.37";"0";"3.33";"Paroxetine";"Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL3226394";"Inhibition of NorA efflux pump in norA-overexpressing Staphylococcus aureus SA-K2378 assessed as reduction in ciprofloxacin MIC at 0.78 to 100 ug/ml by isobologram based checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3217728";"1";"Scientific Literature";"MedChemComm";"2012";"None";""
"CHEMBL3955315";"";"0";"662.75";"3";"5.48";"17";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCC(O)CNCc3ccc(Oc4nnnn4-c4ccccc4)c(OC)c3)cc12";"Inhibition";"'='";"96.9";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3879153";"Inhibition of Staphylococcus aureus 1199B NorA assessed as inhibition of ethidium bromide efflux at 50 uM measured after 5 mins by fluorometric method relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3877305";"1";"Scientific Literature";"J Med Chem";"2017";"None";""
"CHEMBL4483762";"";"0";"357.41";"0";"2.93";"C6";"CCC(/C=C/C(=O)N1CCC[C@@H]1C(=O)OC)=C\c1ccc2c(c1)OCO2";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4480155";"Inhibition of NorA efflux pump overexpressed in Staphylococcus aureus 1199B assessed as increase in EtBr accumulation at 50 ug/ml measured after 30 mins by fluorescence analysis";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4477264";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2016";"None";""
"CHEMBL4169246";"";"0";"408.54";"1";"5.42";"2a";"CCCOc1ccc(-c2cc(OCCN(CC)CC)c3c(OC)cccc3n2)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4151518";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as synergistic potentiation of ciprofloxacin-induced antimicrobial activity at 0.78 ug/ml by microdilution method based Checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL2048632";"";"0";"452.88";"0";"4.88";"3g";"O=[N+]([O-])c1ccc(-n2nc(-c3ccc(Cl)cc3)c3c2-c2ccccc2S(=O)(=O)N3)cc1";"Inhibition";"'='";"76.9";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2051680";"Inhibition of norA-mediated EtBr efflux in Staphylococcus aureus SA1199B overexpressing norA and expressing A116E GrlA mutation at 50 uM by fluorometry";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2046274";"1";"Scientific Literature";"J. Med. Chem.";"2012";"None";""
"CHEMBL4165580";"";"0";"528.65";"2";"6.15";"3d";"CCCOc1ccc(-c2cc(OCCN3CCc4cc(OC)c(OC)cc4C3)c3cc(OC)ccc3n2)cc1";"Inhibition";"'='";"33.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL1421";"DASATINIB";"4";"488.02";"0";"3.31";"73";"Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1";"Inhibition";"'='";"95.8";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4043389";"Inhibition of NorA in Staphylococcus aureus SA1199B harboring GrlA A116E mutant assessed as inhibition of ethidium bromide efflux at 50 uM measured after 5 mins by fluorometric method relative to control";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4043064";"1";"Scientific Literature";"J Med Chem";"2017";"None";""
"CHEMBL2385686";"";"0";"535.08";"1";"6.14";"3o";"CCCOc1ccc(-c2cc(OCCN3CCc4cc(OC)c(OC)cc4C3)c3ccccc3n2)cc1.Cl";"Inhibition";"'='";"79.6";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2390114";"Inhibition of NorA in Staphylococcus aureus 1199B harboring grlA A116E mutant assessed as inhibition of ethidium bromide efflux at 50 uM measured for 5 mins by fluorometric analysis relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL3775483";"";"0";"436.55";"0";"4.28";"27";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCCN3CCOCC3)cc12";"Inhibition";"'='";"98.6";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL1567647";"";"0";"309.37";"0";"3.88";"9";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(O)cc12";"Inhibition";"'='";"1.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL1651020";"";"0";"305.36";"0";"3.22";"56";"CCC(C)N1C(=O)S/C(=C/c2ccc(C(=O)O)cc2)C1=O";"Inhibition";"'='";"0.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL480007";"";"0";"285.37";"0";"3.93";"70";"COc1ccc(C2=Nc3ccccc3SC2)cc1OC";"Inhibition";"'='";"22.8";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651180";"";"0";"378.52";"1";"5.41";"1";"CCCOc1ccc(-c2cc(OCCN(CC)CC)c3ccccc3n2)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4151520";"Inhibition of NorA in Staphylococcus aureus SA-K2378 assessed as synergistic potentiation of ciprofloxacin-induced antimicrobial activity at 0.78 to 100 ug/ml by microdilution method based Checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4530442";"";"0";"411.89";"0";"3.75";"8";"COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)/C=C/C1=C(Cl)c2ccccc2CC1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4311549";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide accumulation at 25 uM measured at 5 mins interval for 60 mins by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4308903";"1";"Scientific Literature";"Bioorg Med Chem";"2019";"None";""
"CHEMBL1630217";"";"0";"622.08";"2";"6.74";"SS14-M";"COc1ccc2c(Cc3cccc(-c4cc5cc([N+](=O)[O-])ccc5[nH]4)c3)c3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2.[Cl-]";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL1638735";"Inhibition of NorA in Staphylococcus aureus K2378 overexpressing NorA assessed as ethidium bromide uptake at 3 uM by fluorescence assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1629702";"1";"Scientific Literature";"Antimicrob. Agents Chemother.";"2010";"None";""
"CHEMBL1651000";"";"0";"391.52";"0";"4.93";"39, specs codeAG-205/33140042";"CCCCOc1ccc([C@H]2C(C#N)=C(N)Oc3cc(N(CC)CC)ccc32)cc1";"Inhibition";"'='";"20.5";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651011";"";"0";"407.56";"1";"6.51";"46";"c1ccc(CCN(Cc2ccccc2)Cc2cccc(OCc3ccccc3)c2)cc1";"Inhibition";"'='";"0.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL479";"THIORIDAZINE";"4";"370.59";"1";"5.89";"62";"CSc1ccc2c(c1)N(CCC1CCCCN1C)c1ccccc1S2";"Inhibition";"'>='";"88.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL3775062";"";"0";"435.57";"0";"3.85";"29";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCCN3CCNCC3)cc12";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL3778150";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199 assessed as potentiation of ciprofloxacin-mediated antibacterial activity";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL3775053";"";"0";"448.61";"1";"5.74";"52";"CCOC(=O)c1c(C)n(Cc2ccc(C)cc2)c2ccc(OCCCN3CCCCC3)cc12";"Inhibition";"'='";"58.3";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL447756";"";"0";"338.31";"0";"4.84";"66";"O=[N+]([O-])c1ccc(C2=Nc3cc(C(F)(F)F)ccc3SC2)cc1";"Inhibition";"'='";"67.9";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651004";"";"0";"493.97";"1";"5.02";"35, specs codeAN-465/15401006";"COc1cc(/C=C2\S/C(=N\c3ccccc3)N(c3ccccc3)C2=O)cc(Cl)c1OCC(N)=O";"Inhibition";"'='";"18.3";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651180";"";"0";"378.52";"1";"5.41";"1";"CCCOc1ccc(-c2cc(OCCN(CC)CC)c3ccccc3n2)cc1";"Inhibition";"'='";"93.4";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL4155967";"Inhibition of Staphylococcus aureus SA-1199B NorA assessed as reduction in EtBr efflux at 50 uM measured over 5 mins by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4152305";"1";"Scientific Literature";"Eur J Med Chem";"2018";"None";""
"CHEMBL1087296";"TRICHOSTACHINE";"0";"271.32";"0";"2.61";"Piperine";"O=C(/C=C/C=C/c1ccc2c(c1)OCO2)N1CCCC1";"Inhibition";"'='";"58.46";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4311539";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM measured over 5 mins interval for 30 mins by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4308903";"1";"Scientific Literature";"Bioorg Med Chem";"2019";"None";""
"CHEMBL4539308";"";"0";"434.92";"0";"4.52";"7";"COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)/C=C/C1=C(Cl)c2ccccc2CC1";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL4311549";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide accumulation at 25 uM measured at 5 mins interval for 60 mins by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4308903";"1";"Scientific Literature";"Bioorg Med Chem";"2019";"None";""
"CHEMBL2385690";"";"0";"481.64";"1";"5.89";"3s";"CCCOc1ccc(-c2cc(OCCN3CCN(Cc4ccccc4)CC3)c3ccccc3n2)cc1";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL2390106";"Inhibition of wild type NorA in Staphylococcus aureus 1199 assessed as reduction of ciprofloxacin MIC at 0.78 to 100 ug/mL";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL4172372";"";"0";"408.54";"1";"5.42";"4a";"CCCOc1ccc(-c2cc(OCCN(CC)CC)c3ccc(OC)cc3n2)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4151518";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as synergistic potentiation of ciprofloxacin-induced antimicrobial activity at 0.78 ug/ml by microdilution method based Checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL2385690";"";"0";"481.64";"1";"5.89";"3s";"CCCOc1ccc(-c2cc(OCCN3CCN(Cc4ccccc4)CC3)c3ccccc3n2)cc1";"Inhibition";"'='";"81.2";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2390114";"Inhibition of NorA in Staphylococcus aureus 1199B harboring grlA A116E mutant assessed as inhibition of ethidium bromide efflux at 50 uM measured for 5 mins by fluorometric analysis relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL2385667";"";"0";"448.56";"0";"4.91";"3x";"CCCOc1ccc(-c2cc(OCCN3CCC4(CC3)OCCO4)c3ccccc3n2)cc1";"Inhibition";"'='";"80.4";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2390114";"Inhibition of NorA in Staphylococcus aureus 1199B harboring grlA A116E mutant assessed as inhibition of ethidium bromide efflux at 50 uM measured for 5 mins by fluorometric analysis relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL4164426";"";"0";"450.58";"1";"5.57";"7b";"CCCOc1ccc(-c2cc(OCCN3CCCCC3)c3cc(OC)c(OC)cc3n2)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4151517";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as synergistic potentiation of ciprofloxacin-induced antimicrobial activity at 0.78 to 100 ug/ml by microdilution method based Checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4175014";"";"0";"558.68";"2";"6.16";"6d";"CCCOc1ccc(-c2cc(OCCN3CCc4cc(OC)c(OC)cc4C3)c3c(OC)cc(OC)cc3n2)cc1";"Inhibition";"'='";"86.5";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4164426";"";"0";"450.58";"1";"5.57";"7b";"CCCOc1ccc(-c2cc(OCCN3CCCCC3)c3cc(OC)c(OC)cc3n2)cc1";"Inhibition";"'='";"92.1";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4563966";"";"0";"345.83";"0";"3.30";"6";"COC(=O)[C@@H]1CCCN1C(=O)/C=C/C1=C(Cl)c2ccccc2CC1";"Inhibition";"'>'";"80.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4311545";"Inhibition of NorA Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 6.25 to 50 uM measured after 5 mins by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4308903";"1";"Scientific Literature";"Bioorg Med Chem";"2019";"None";""
"CHEMBL4468269";"";"0";"305.76";"0";"2.43";"15";"COC(=O)CNC(=O)/C=C/C1=C(Cl)c2ccccc2CC1";"Inhibition";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL4311538";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM measured after 5 mins by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4308903";"1";"Scientific Literature";"Bioorg Med Chem";"2019";"None";""
"CHEMBL4560759";"";"0";"345.83";"0";"3.30";"16";"COC(=O)[C@H]1CCCN1C(=O)/C=C/C1=C(Cl)c2ccccc2CC1";"Inhibition";"'='";"52.59";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4311538";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM measured after 5 mins by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4308903";"1";"Scientific Literature";"Bioorg Med Chem";"2019";"None";""
"CHEMBL1651176";"";"0";"339.39";"0";"3.71";"91";"CCCOc1ccc(-c2cc(=O)c3cc(OC)c(O)cc3n2C)cc1";"Inhibition";"'='";"9.1";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651163";"";"0";"390.53";"0";"4.94";"95";"CCCOc1ccc(-c2cc(=O)c3ccccc3n2CCN2CCCCC2)cc1";"Inhibition";"'='";"75.1";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1649602";"";"0";"453.56";"0";"3.51";"101";"CCOC(=O)c1cn(C2CC2)c2cc(N3CCC4=C(C3)C(=O)C(C)CS4)c(N)cc2c1=O";"Inhibition";"'='";"63.5";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651169";"";"0";"362.47";"0";"4.07";"84";"Cn1c(-c2ccc(OCCN3CCCCC3)cc2)cc(=O)c2ccccc21";"Inhibition";"'='";"19.8";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL4437595";"";"0";"319.79";"0";"2.82";"13";"COC(=O)CCNC(=O)/C=C/C1=C(Cl)c2ccccc2CC1";"Inhibition";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL4311538";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM measured after 5 mins by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4308903";"1";"Scientific Literature";"Bioorg Med Chem";"2019";"None";""
"CHEMBL4475256";"";"0";"319.79";"0";"2.82";"18";"COC(=O)[C@H](C)NC(=O)/C=C/C1=C(Cl)c2ccccc2CC1";"Inhibition";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL4311538";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM measured after 5 mins by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4308903";"1";"Scientific Literature";"Bioorg Med Chem";"2019";"None";""
"CHEMBL4539308";"";"0";"434.92";"0";"4.52";"7";"COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)/C=C/C1=C(Cl)c2ccccc2CC1";"Inhibition";"'='";"83.87";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4311539";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM measured over 5 mins interval for 30 mins by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4308903";"1";"Scientific Literature";"Bioorg Med Chem";"2019";"None";""
"CHEMBL1650990";"";"0";"464.53";"0";"2.93";"22, specs codeAP-906/41638445";"CCOc1ccc(C2C(C(=O)Nc3cccnc3)=C(C)Nc3nc(CCCO)nn32)cc1OC";"Inhibition";"'='";"14.8";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1630217";"";"0";"622.08";"2";"6.74";"SS14-M";"COc1ccc2c(Cc3cccc(-c4cc5cc([N+](=O)[O-])ccc5[nH]4)c3)c3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2.[Cl-]";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL1638736";"Inhibition of NorA in Staphylococcus aureus 8325-4 assessed as increase in ethidium bromide uptake at 3 uM by fluorescence assay in presence of INF55";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1629702";"1";"Scientific Literature";"Antimicrob. Agents Chemother.";"2010";"None";""
"CHEMBL4175014";"";"0";"558.68";"2";"6.16";"6d";"CCCOc1ccc(-c2cc(OCCN3CCc4cc(OC)c(OC)cc4C3)c3c(OC)cc(OC)cc3n2)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4151518";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as synergistic potentiation of ciprofloxacin-induced antimicrobial activity at 0.78 ug/ml by microdilution method based Checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL2159001";"";"0";"320.39";"0";"3.39";"17";"CN(C)CCOc1ccc(C(=O)/C=C/c2ccc(C#N)cc2)cc1";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL2162198";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL4525263";"";"0";"333.82";"0";"3.21";"12";"COC(=O)C(C)(C)NC(=O)/C=C/C1=C(Cl)c2ccccc2CC1";"Inhibition";"'='";"41.35";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4311538";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM measured after 5 mins by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4308903";"1";"Scientific Literature";"Bioorg Med Chem";"2019";"None";""
"CHEMBL422481";"";"0";"284.31";"0";"3.31";"6";"COc1ccc(OC)c(/C=C/C(=O)c2ccc(O)cc2)c1";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL2162198";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL142493";"";"0";"284.31";"0";"3.31";"2";"COc1cccc(/C=C/C(=O)c2ccc(O)cc2)c1OC";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL2162198";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL2159002";"";"0";"313.37";"0";"3.66";"18";"CN(C)CCOc1ccc(C(=O)/C=C/c2cccc(F)c2)cc1";"Inhibition";"";"";"";"";"";"tde";"";"";"";"";"";"False";"CHEMBL2162184";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL141664";"";"0";"324.38";"0";"4.16";"14";"C=CCOc1ccc(C(=O)/C=C/c2cccc(OC)c2OC)cc1";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL2162198";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL148216";"";"0";"358.39";"0";"3.63";"13";"COc1cc(/C=C/C(=O)c2ccc(OC)c(OC)c2OC)cc(OC)c1";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL2162198";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL2159000";"";"0";"388.42";"0";"4.82";"11";"COc1cc(/C=C/C(=O)c2cccc(OC(=O)c3ccccc3)c2)cc(OC)c1";"Inhibition";"";"";"";"";"";"tde";"";"";"";"";"";"False";"CHEMBL2162184";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL772";"RESERPINE";"4";"608.69";"1";"4.17";"Reserpine";"COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC";"Inhibition";"'='";"83.06";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4311539";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM measured over 5 mins interval for 30 mins by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4308903";"1";"Scientific Literature";"Bioorg Med Chem";"2019";"None";""
"CHEMBL4162139";"";"0";"420.55";"1";"5.56";"3b";"CCCOc1ccc(-c2cc(OCCN3CCCCC3)c3cc(OC)ccc3n2)cc1";"Inhibition";"'='";"97.6";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4174957";"";"0";"528.65";"2";"6.15";"4d";"CCCOc1ccc(-c2cc(OCCN3CCc4cc(OC)c(OC)cc4C3)c3ccc(OC)cc3n2)cc1";"Inhibition";"'='";"91.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4165958";"";"0";"528.65";"2";"6.15";"5d";"CCCOc1ccc(-c2cc(OCCN3CCc4cc(OC)c(OC)cc4C3)c3cccc(OC)c3n2)cc1";"Inhibition";"'='";"65.5";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4160603";"";"0";"464.61";"1";"5.96";"6c";"CCCOc1ccc(-c2cc(OCCN3CCCCCC3)c3c(OC)cc(OC)cc3n2)cc1";"Inhibition";"'='";"74.1";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4170066";"";"0";"558.68";"2";"6.16";"8d";"CCCOc1ccc(-c2cc(OCCN3CCc4cc(OC)c(OC)cc4C3)c3cc(OC)cc(OC)c3n2)cc1";"Inhibition";"'='";"86.7";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4173512";"";"0";"371.86";"1";"5.32";"19";"CCCOc1ccc(-c2cc(OCCCl)c3cc(OC)ccc3n2)cc1";"Inhibition";"'='";"10.5";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4176162";"";"0";"394.52";"1";"5.03";"4e";"CCCOc1ccc(-c2cc(OCCCN(C)C)c3ccc(OC)cc3n2)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4151517";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as synergistic potentiation of ciprofloxacin-induced antimicrobial activity at 0.78 to 100 ug/ml by microdilution method based Checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4171241";"";"0";"421.54";"0";"3.98";"5g";"CCCOc1ccc(-c2cc(OCCN3CCNCC3)c3cccc(OC)c3n2)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4151517";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as synergistic potentiation of ciprofloxacin-induced antimicrobial activity at 0.78 to 100 ug/ml by microdilution method based Checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4172302";"";"0";"464.61";"1";"5.96";"7c";"CCCOc1ccc(-c2cc(OCCN3CCCCCC3)c3cc(OC)c(OC)cc3n2)cc1";"Inhibition";"'='";"67.9";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4168943";"";"0";"438.57";"1";"5.43";"8a";"CCCOc1ccc(-c2cc(OCCN(CC)CC)c3cc(OC)cc(OC)c3n2)cc1";"Inhibition";"'='";"92.4";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4172372";"";"0";"408.54";"1";"5.42";"4a";"CCCOc1ccc(-c2cc(OCCN(CC)CC)c3ccc(OC)cc3n2)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4151520";"Inhibition of NorA in Staphylococcus aureus SA-K2378 assessed as synergistic potentiation of ciprofloxacin-induced antimicrobial activity at 0.78 to 100 ug/ml by microdilution method based Checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL2158993";"";"0";"385.46";"0";"3.55";"20";"COc1ccc(C(=O)/C=C/c2cccc(OCCN(C)C)c2)c(OC)c1OC";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL2162181";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml after 150 to 160 secs by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL2159002";"";"0";"313.37";"0";"3.66";"18";"CN(C)CCOc1ccc(C(=O)/C=C/c2cccc(F)c2)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL2162181";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml after 150 to 160 secs by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL145666";"";"0";"314.34";"0";"3.31";"16";"COc1cc(OC)c(/C=C/C(=O)c2ccc(O)cc2)c(OC)c1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL2162181";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml after 150 to 160 secs by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL2158993";"";"0";"385.46";"0";"3.55";"20";"COc1ccc(C(=O)/C=C/c2cccc(OCCN(C)C)c2)c(OC)c1OC";"Inhibition";"";"";"";"";"";"tde";"";"";"";"";"";"False";"CHEMBL2162184";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux at 2 ug/ml by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL2385688";"";"0";"391.52";"0";"3.97";"3q";"CCCOc1ccc(-c2cc(OCCN3CCNCC3)c3ccccc3n2)cc1";"Inhibition";"'='";"93.4";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2390114";"Inhibition of NorA in Staphylococcus aureus 1199B harboring grlA A116E mutant assessed as inhibition of ethidium bromide efflux at 50 uM measured for 5 mins by fluorometric analysis relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL2385688";"";"0";"391.52";"0";"3.97";"3q";"CCCOc1ccc(-c2cc(OCCN3CCNCC3)c3ccccc3n2)cc1";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL2390107";"Inhibition of NorA in Staphylococcus aureus ATCC 25923 assessed as reduction of ciprofloxacin MIC at 0.78 to 100 ug/mL";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL2048630";"";"0";"425.87";"1";"5.11";"3c";"O=S1(=O)Nc2c(-c3ccc(Cl)cc3)nn(-c3ccc(F)cc3)c2-c2ccccc21";"Inhibition";"'='";"15.5";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2051680";"Inhibition of norA-mediated EtBr efflux in Staphylococcus aureus SA1199B overexpressing norA and expressing A116E GrlA mutation at 50 uM by fluorometry";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2046274";"1";"Scientific Literature";"J. Med. Chem.";"2012";"None";""
"CHEMBL2385683";"";"0";"376.50";"1";"5.17";"3l";"CCCOc1ccc(-c2cc(OCCN3CCCC3)c3ccccc3n2)cc1";"Inhibition";"'='";"94.2";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2390114";"Inhibition of NorA in Staphylococcus aureus 1199B harboring grlA A116E mutant assessed as inhibition of ethidium bromide efflux at 50 uM measured for 5 mins by fluorometric analysis relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL192";"SILDENAFIL";"4";"474.59";"0";"1.61";"75";"CCCc1nn(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCN(C)CC4)ccc3OCC)nc12";"Inhibition";"'='";"22.9";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4043389";"Inhibition of NorA in Staphylococcus aureus SA1199B harboring GrlA A116E mutant assessed as inhibition of ethidium bromide efflux at 50 uM measured after 5 mins by fluorometric method relative to control";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4043064";"1";"Scientific Literature";"J Med Chem";"2017";"None";""
"CHEMBL1651180";"";"0";"378.52";"1";"5.41";"1";"CCCOc1ccc(-c2cc(OCCN(CC)CC)c3ccccc3n2)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4043398";"Inhibition of NorA in Staphylococcus aureus SA1199B harboring GrlA A116E mutant assessed as potentiation of CPX-induced antimicrobial activity up to 100 ug/ml by checkerboard assay";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4043064";"1";"Scientific Literature";"J Med Chem";"2017";"None";""
"CHEMBL2158998";"";"0";"387.48";"1";"5.32";"9";"CN(C)CCOc1ccc(C(=O)/C=C/c2ccc(Oc3ccccc3)cc2)cc1";"Inhibition";"'='";"99.1";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2162179";"Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B at 20 ug/ml by spectrofluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL434066";"";"0";"284.31";"0";"3.31";"4";"COc1ccc(/C=C/C(=O)c2ccc(O)cc2)c(OC)c1";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL2162198";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL490";"PAROXETINE";"4";"329.37";"0";"3.33";"paroxetine";"Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL2051686";"Inhibition of norA in wild type Staphylococcus aureus SA1199 expressing assessed as potentiation of ciprofloxacin MIC by checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2046274";"1";"Scientific Literature";"J. Med. Chem.";"2012";"None";""
"CHEMBL4166649";"";"0";"339.39";"0";"4.41";"32";"CCCOc1ccc(-c2cc(O)c3cc(OC)c(OC)cc3n2)cc1";"Inhibition";"'='";"79.2";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL2158992";"";"0";"313.37";"0";"3.66";"19";"CN(C)CCOc1ccc(C(=O)/C=C/c2ccc(F)cc2)cc1";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL2162198";"Inhibition of Staphylococcus aureus SA-1199B NorA expressed in Escherichia coli DH10B assessed as inhibition of Hoechst 33342 dye efflux by spectrofluorometric analysis in presence of 50 uM Mg2+";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2157969";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None";""
"CHEMBL457109";"";"0";"275.74";"0";"3.44";"25";"NCc1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1";"Inhibition";"'='";"20.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1017717";"Inhibition of NorA efflux pump in Staphylococcus aureus K2361 assessed as reduction of ethidium bromide efflux at 0.5 uM for 5 mins";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1154468";"1";"Scientific Literature";"Eur. J. Med. Chem.";"2008";"None";""
"CHEMBL3774842";"";"0";"351.40";"0";"4.10";"10";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OC(C)=O)cc12";"Inhibition";"'='";"20.4";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL3775105";"";"0";"434.58";"1";"5.43";"25";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCCN3CCCCC3)cc12";"Inhibition";"'='";"98.5";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL3774445";"";"0";"380.49";"0";"4.29";"35";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCCCN)cc12";"Inhibition";"'='";"93.7";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL3775507";"";"0";"382.46";"0";"2.87";"41";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCC(O)CN)cc12";"Inhibition";"'='";"100.0";"%";"";"";"";"UO_0000187";"";"";"";"";"True";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL3774776";"";"0";"452.57";"1";"5.38";"44";"CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCC(CF)N3CCCCC3)cc12";"Inhibition";"'='";"38.5";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL2385684";"";"0";"404.55";"1";"5.95";"3m";"CCCOc1ccc(-c2cc(OCCN3CCCCCC3)c3ccccc3n2)cc1";"Inhibition";"'='";"86.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2390114";"Inhibition of NorA in Staphylococcus aureus 1199B harboring grlA A116E mutant assessed as inhibition of ethidium bromide efflux at 50 uM measured for 5 mins by fluorometric analysis relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL2385670";"";"0";"386.92";"0";"4.63";"3b";"CCCOc1ccc(-c2cc(OCCN(C)C)c3ccccc3n2)cc1.Cl";"Inhibition";"'='";"92.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2390114";"Inhibition of NorA in Staphylococcus aureus 1199B harboring grlA A116E mutant assessed as inhibition of ethidium bromide efflux at 50 uM measured for 5 mins by fluorometric analysis relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2384986";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None";""
"CHEMBL1213033";"APRINDINE";"0";"322.50";"0";"4.39";"11";"CCN(CC)CCCN(c1ccccc1)C1Cc2ccccc2C1";"Inhibition";"'='";"51.6";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2049765";"Inhibition of norA-mediated ethidium bromide efflux in Staphylococcus aureus SA-1199B harboring grlA A116E mutant at 50 uM after 5 mins by fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL2046272";"1";"Scientific Literature";"ACS Med. Chem. Lett.";"2012";"None";""
"CHEMBL4531323";"";"0";"395.89";"0";"4.04";"14";"COC(=O)[C@H](Cc1ccccc1)NC(=O)/C=C/C1=C(Cl)c2ccccc2CC1";"Inhibition";"'='";"48.04";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4311538";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM measured after 5 mins by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4308903";"1";"Scientific Literature";"Bioorg Med Chem";"2019";"None";""
"CHEMBL4466225";"";"0";"361.87";"0";"3.84";"17";"COC(=O)[C@H](CC(C)C)NC(=O)/C=C/C1=C(Cl)c2ccccc2CC1";"Inhibition";"'='";"56.23";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4311538";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM measured after 5 mins by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4308903";"1";"Scientific Literature";"Bioorg Med Chem";"2019";"None";""
"CHEMBL481678";"";"0";"297.42";"1";"5.02";"78";"CCCOc1ccc(C2=CSc3ccccc3N2C)cc1";"Inhibition";"'='";"0.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL3775401";"";"0";"452.57";"1";"5.57";"57";"CCOC(=O)c1c(C)n(Cc2cccc(F)c2)c2ccc(OCCCN3CCCCC3)cc12";"Inhibition";"'='";"89.7";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL3775789";"";"0";"452.57";"1";"5.57";"58";"CCOC(=O)c1c(C)n(Cc2ccc(F)cc2)c2ccc(OCCCN3CCCCC3)cc12";"Inhibition";"'='";"91.1";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3777946";"Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux at 50 uM incubated for 20 mins measured for 5 mins by real-time fluorometric analysis";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL3774342";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None";""
"CHEMBL4172372";"";"0";"408.54";"1";"5.42";"4a";"CCCOc1ccc(-c2cc(OCCN(CC)CC)c3ccc(OC)cc3n2)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4151517";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as synergistic potentiation of ciprofloxacin-induced antimicrobial activity at 0.78 to 100 ug/ml by microdilution method based Checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL1651184";"";"0";"439.54";"0";"3.27";"10";"CCOC(=O)c1cn(C2CC2)c2cc(N3CCC4=C(C3)C(=O)CCS4)c(N)cc2c1=O";"Inhibition";"'='";"35.7";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL1657423";"Inhibition of NorA in Staphylococcus aureus 1199B assessed as reduction in ethidium bromide efflux at 50 uM by fluorimetry after 5 mins";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL1649083";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None";""
"CHEMBL1651180";"";"0";"378.52";"1";"5.41";"1";"CCCOc1ccc(-c2cc(OCCN(CC)CC)c3ccccc3n2)cc1";"Inhibition";"'='";"93.4";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4168943";"";"0";"438.57";"1";"5.43";"8a";"CCCOc1ccc(-c2cc(OCCN(CC)CC)c3cc(OC)cc(OC)c3n2)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4151517";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as synergistic potentiation of ciprofloxacin-induced antimicrobial activity at 0.78 to 100 ug/ml by microdilution method based Checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4177278";"";"0";"371.86";"1";"5.32";"33";"CCCOc1ccc(-c2cc(OCCCl)c3ccc(OC)cc3n2)cc1";"Inhibition";"'='";"57.5";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4174957";"";"0";"528.65";"2";"6.15";"4d";"CCCOc1ccc(-c2cc(OCCN3CCc4cc(OC)c(OC)cc4C3)c3ccc(OC)cc3n2)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4151517";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as synergistic potentiation of ciprofloxacin-induced antimicrobial activity at 0.78 to 100 ug/ml by microdilution method based Checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4170066";"";"0";"558.68";"2";"6.16";"8d";"CCCOc1ccc(-c2cc(OCCN3CCc4cc(OC)c(OC)cc4C3)c3cc(OC)cc(OC)c3n2)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4151518";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as synergistic potentiation of ciprofloxacin-induced antimicrobial activity at 0.78 ug/ml by microdilution method based Checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4169246";"";"0";"408.54";"1";"5.42";"2a";"CCCOc1ccc(-c2cc(OCCN(CC)CC)c3c(OC)cccc3n2)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4151517";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as synergistic potentiation of ciprofloxacin-induced antimicrobial activity at 0.78 to 100 ug/ml by microdilution method based Checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4164053";"";"0";"406.53";"1";"5.26";"9";"CCCOc1ccc(-c2cc(OCCN3CCCCC3)c3cc(O)ccc3n2)cc1";"Inhibition";"'='";"87.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4155967";"Inhibition of Staphylococcus aureus SA-1199B NorA assessed as reduction in EtBr efflux at 50 uM measured over 5 mins by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4152305";"1";"Scientific Literature";"Eur J Med Chem";"2018";"None";""
"CHEMBL4160250";"";"0";"479.67";"1";"5.74";"10d";"CCCOc1ccc(-c2cc(OCCN(CC)CC)c3cc(OCCCN(C)C)ccc3n2)cc1";"Inhibition";"'='";"80.9";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4155967";"Inhibition of Staphylococcus aureus SA-1199B NorA assessed as reduction in EtBr efflux at 50 uM measured over 5 mins by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4152305";"1";"Scientific Literature";"Eur J Med Chem";"2018";"None";""
"CHEMBL4163342";"";"0";"438.57";"1";"5.43";"6a";"CCCOc1ccc(-c2cc(OCCN(CC)CC)c3c(OC)cc(OC)cc3n2)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4151517";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as synergistic potentiation of ciprofloxacin-induced antimicrobial activity at 0.78 to 100 ug/ml by microdilution method based Checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4169005";"";"0";"511.67";"2";"5.90";"3f";"CCCOc1ccc(-c2cc(OCCN3CCN(Cc4ccccc4)CC3)c3cc(OC)ccc3n2)cc1";"Inhibition";"'='";"32.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4169246";"";"0";"408.54";"1";"5.42";"2a";"CCCOc1ccc(-c2cc(OCCN(CC)CC)c3c(OC)cccc3n2)cc1";"Inhibition";"'='";"96.5";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4151511";"Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL4170066";"";"0";"558.68";"2";"6.16";"8d";"CCCOc1ccc(-c2cc(OCCN3CCc4cc(OC)c(OC)cc4C3)c3cc(OC)cc(OC)c3n2)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4151520";"Inhibition of NorA in Staphylococcus aureus SA-K2378 assessed as synergistic potentiation of ciprofloxacin-induced antimicrobial activity at 0.78 to 100 ug/ml by microdilution method based Checkerboard assay";"B";"BAO_0000357";"single protein format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4145675";"1";"Scientific Literature";"J Med Chem";"2018";"None";""
"CHEMBL3741903";"";"0";"560.70";"1";"4.97";"C18";"CCCCC(=O)NC1(CC(=O)NNc2ccccc2)CCN(C(=O)/C=C/C(=C/c2ccc3c(c2)OCO3)CC)CC1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4480155";"Inhibition of NorA efflux pump overexpressed in Staphylococcus aureus 1199B assessed as increase in EtBr accumulation at 50 ug/ml measured after 30 mins by fluorescence analysis";"B";"BAO_0000019";"assay format";"Staphylococcus aureus";"None";"None";"None";"None";"";"";"";"CHEMBL5114";"Quinolone resistance protein norA";"Staphylococcus aureus";"SINGLE PROTEIN";"CHEMBL4477264";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2016";"None";""