diff --git a/src/ontology/go-edit.obo b/src/ontology/go-edit.obo
index 98554b39e9..ddd26a2cd7 100644
--- a/src/ontology/go-edit.obo
+++ b/src/ontology/go-edit.obo
@@ -89293,7 +89293,7 @@ synonym: "GDP-mannose formation" EXACT []
 synonym: "GDP-mannose synthesis" EXACT []
 xref: MetaCyc:PWY-5659
 intersection_of: GO:0009058 ! biosynthetic process
-intersection_of: has_primary_output CHEBI:21168 ! GDP-mannose
+intersection_of: has_primary_output CHEBI:57527 ! GDP-alpha-D-mannose(2-)
 relationship: has_part GO:0004615 ! phosphomannomutase activity
 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/23283" xsd:anyURI
 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27107" xsd:anyURI
@@ -359195,7 +359195,7 @@ namespace: biological_process
 def: "The chemical reactions and pathways resulting in the formation of GDP-mannose from mannose." [GOC:dph, PMID:16339137, PMID:24218558]
 intersection_of: GO:0009058 ! biosynthetic process
 intersection_of: has_primary_input CHEBI:37684 ! mannose
-intersection_of: has_primary_output CHEBI:21168 ! GDP-mannose
+intersection_of: has_primary_output CHEBI:57527 ! GDP-alpha-D-mannose(2-)
 relationship: starts_with GO:0019158 ! mannokinase activity
 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27683" xsd:anyURI
 created_by: dph
@@ -359209,7 +359209,7 @@ def: "The chemical reactions and pathways resulting in the formation of GDP-mann
 xref: Reactome:R-HSA-446205 "Synthesis of GDP-mannose, Homo sapiens"
 intersection_of: GO:0009058 ! biosynthetic process
 intersection_of: has_primary_input CHEBI:78697 ! D-fructose 6-phosphate
-intersection_of: has_primary_output CHEBI:21168 ! GDP-mannose
+intersection_of: has_primary_output CHEBI:57527 ! GDP-alpha-D-mannose(2-)
 relationship: starts_with GO:0004476 ! mannose-6-phosphate isomerase activity
 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27683" xsd:anyURI
 created_by: dph
@@ -459262,7 +459262,7 @@ def: "The chemical reactions and pathways resulting in the formation of GDP-mann
 xref: MetaCyc:PWY-5659
 intersection_of: GO:0009058 ! biosynthetic process
 intersection_of: has_primary_input CHEBI:4167 ! D-glucopyranose
-intersection_of: has_primary_output CHEBI:21168 ! GDP-mannose
+intersection_of: has_primary_output CHEBI:57527 ! GDP-alpha-D-mannose(2-)
 relationship: starts_with GO:0004347 ! glucose-6-phosphate isomerase activity
 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27683" xsd:anyURI
 created_by: pg