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polyadenylation-dependent catabolic process- relabel terms #26801

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ValWood opened this issue Jan 16, 2024 · 1 comment
Open

polyadenylation-dependent catabolic process- relabel terms #26801

ValWood opened this issue Jan 16, 2024 · 1 comment
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non-coding RNA RNA processes

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ValWood commented Jan 16, 2024 •
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Need to check this (I.e other annotations), but I'm pretty sure that this is referring to TRAMP-exosome dependent pathway. However the current labels are problematic because MOST other unrelated RNA decay is polyadenylation dependent.

In fact TRAMP really appears to degrade RNAs that are not polyadnylated by the CPF, but since exosome substrate recognition requires a polyA sequence TRAMP cid14 adds a short number of AAA's

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@ValWood ValWood self-assigned this Jan 16, 2024
@ValWood ValWood changed the title polyadenylation catabolic process polyadenylation catabolic process- relabel terms Jan 16, 2024
@ValWood ValWood changed the title polyadenylation catabolic process- relabel terms polyadenylation-dependent catabolic process- relabel terms Jan 16, 2024
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ValWood commented Feb 6, 2024

need to double check this, some are TRAMP/ Some are MTREC/NURS-exosome

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non-coding RNA RNA processes
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RNA processing reorganization
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