diff --git a/packages/browser-integration-tests/suites/replay/slowClick/template.html b/packages/browser-integration-tests/suites/replay/slowClick/template.html
index 1cf757f7b974..763a24430b71 100644
--- a/packages/browser-integration-tests/suites/replay/slowClick/template.html
+++ b/packages/browser-integration-tests/suites/replay/slowClick/template.html
@@ -18,6 +18,7 @@
     <button id="scrollButton">Trigger scroll</button>
     <button id="scrollLateButton">Trigger scroll late</button>
     <button id="mutationIgnoreButton" class="ignore-class">Trigger scroll late</button>
+    <button id="windowOpenButton">Window open</button>
 
     <a href="#" id="link">Link</a>
     <a href="#" target="_blank" id="linkExternal">Link external</a>
@@ -69,6 +70,11 @@ <h1 id="h2">Bottom</h1>
           console.log('DONE');
         }, 3001);
       });
+      document.getElementById('windowOpenButton').addEventListener('click', () => {
+        setTimeout(() => {
+          window.open('.');
+        }, 3001);
+      });
 
       // Do nothing on these elements
       document
diff --git a/packages/browser-integration-tests/suites/replay/slowClick/windowOpen/test.ts b/packages/browser-integration-tests/suites/replay/slowClick/windowOpen/test.ts
new file mode 100644
index 000000000000..d4cc0ae7de5a
--- /dev/null
+++ b/packages/browser-integration-tests/suites/replay/slowClick/windowOpen/test.ts
@@ -0,0 +1,62 @@
+import { expect } from '@playwright/test';
+
+import { sentryTest } from '../../../../utils/fixtures';
+import { getCustomRecordingEvents, shouldSkipReplayTest, waitForReplayRequest } from '../../../../utils/replayHelpers';
+
+sentryTest('window.open() is considered for slow click', async ({ getLocalTestUrl, page }) => {
+  if (shouldSkipReplayTest()) {
+    sentryTest.skip();
+  }
+
+  const reqPromise0 = waitForReplayRequest(page, 0);
+
+  await page.route('https://dsn.ingest.sentry.io/**/*', route => {
+    return route.fulfill({
+      status: 200,
+      contentType: 'application/json',
+      body: JSON.stringify({ id: 'test-id' }),
+    });
+  });
+
+  const url = await getLocalTestUrl({ testDir: __dirname });
+
+  await page.goto(url);
+  await reqPromise0;
+
+  const reqPromise1 = waitForReplayRequest(page, (event, res) => {
+    const { breadcrumbs } = getCustomRecordingEvents(res);
+
+    return breadcrumbs.some(breadcrumb => breadcrumb.category === 'ui.slowClickDetected');
+  });
+
+  await page.click('#windowOpenButton');
+
+  const { breadcrumbs } = getCustomRecordingEvents(await reqPromise1);
+
+  const slowClickBreadcrumbs = breadcrumbs.filter(breadcrumb => breadcrumb.category === 'ui.slowClickDetected');
+
+  expect(slowClickBreadcrumbs).toEqual([
+    {
+      category: 'ui.slowClickDetected',
+      data: {
+        endReason: 'window.open',
+        node: {
+          attributes: {
+            id: 'windowOpenButton',
+          },
+          id: expect.any(Number),
+          tagName: 'button',
+          textContent: '****** ****',
+        },
+        nodeId: expect.any(Number),
+        timeAfterClickMs: expect.any(Number),
+        url: 'http://sentry-test.io/index.html',
+      },
+      message: 'body > button#windowOpenButton',
+      timestamp: expect.any(Number),
+    },
+  ]);
+
+  expect(slowClickBreadcrumbs[0]?.data?.timeAfterClickMs).toBeGreaterThan(3000);
+  expect(slowClickBreadcrumbs[0]?.data?.timeAfterClickMs).toBeLessThan(3100);
+});
diff --git a/packages/replay/src/coreHandlers/handleSlowClick.ts b/packages/replay/src/coreHandlers/handleSlowClick.ts
index c939a990f87a..9e486a060706 100644
--- a/packages/replay/src/coreHandlers/handleSlowClick.ts
+++ b/packages/replay/src/coreHandlers/handleSlowClick.ts
@@ -3,6 +3,7 @@ import type { Breadcrumb } from '@sentry/types';
 import { WINDOW } from '../constants';
 import type { ReplayContainer, SlowClickConfig } from '../types';
 import { addBreadcrumbEvent } from './util/addBreadcrumbEvent';
+import { onWindowOpen } from './util/onWindowOpen';
 
 type ClickBreadcrumb = Breadcrumb & {
   timestamp: number;
@@ -61,6 +62,11 @@ export function detectSlowClick(
 
   WINDOW.addEventListener('scroll', scrollHandler);
 
+  const cleanupWindowOpen = onWindowOpen(() => {
+    maybeHandleSlowClick(replay, clickBreadcrumb, config.threshold, config.timeout, 'window.open');
+    cleanup();
+  });
+
   // Stop listening to scroll timeouts early
   const scrollTimeout = setTimeout(() => {
     WINDOW.removeEventListener('scroll', scrollHandler);
@@ -71,6 +77,7 @@ export function detectSlowClick(
     clearTimeout(scrollTimeout);
     obs.disconnect();
     WINDOW.removeEventListener('scroll', scrollHandler);
+    cleanupWindowOpen();
   };
 }
 
diff --git a/packages/replay/src/coreHandlers/util/onWindowOpen.ts b/packages/replay/src/coreHandlers/util/onWindowOpen.ts
new file mode 100644
index 000000000000..e3b6b7ac92ed
--- /dev/null
+++ b/packages/replay/src/coreHandlers/util/onWindowOpen.ts
@@ -0,0 +1,44 @@
+import { fill } from '@sentry/utils';
+
+import { WINDOW } from '../../constants';
+
+type WindowOpenHandler = () => void;
+
+let handlers: undefined | WindowOpenHandler[];
+
+/**
+ * Register a handler to be called when `window.open()` is called.
+ * Returns a cleanup function.
+ */
+export function onWindowOpen(cb: WindowOpenHandler): () => void {
+  // Ensure to only register this once
+  if (!handlers) {
+    handlers = [];
+    monkeyPatchWindowOpen();
+  }
+
+  handlers.push(cb);
+
+  return () => {
+    const pos = handlers ? handlers.indexOf(cb) : -1;
+    if (pos > -1) {
+      (handlers as WindowOpenHandler[]).splice(pos, 1);
+    }
+  };
+}
+
+function monkeyPatchWindowOpen(): void {
+  fill(WINDOW, 'open', function (originalWindowOpen: () => void): () => void {
+    return function (...args: unknown[]): void {
+      if (handlers) {
+        try {
+          handlers.forEach(handler => handler());
+        } catch (e) {
+          // ignore errors in here
+        }
+      }
+
+      return originalWindowOpen.apply(WINDOW, args);
+    };
+  });
+}