diff --git a/constraints.txt b/constraints.txt
deleted file mode 100644
index 697aca1388..0000000000
--- a/constraints.txt
+++ /dev/null
@@ -1,3 +0,0 @@
-# Workaround for https://github.com/pypa/setuptools/issues/4519.
-# Applies only for Django tests.
-setuptools<72.0.0
diff --git a/tox.ini b/tox.ini
index 2b5ef6d8d2..771144208d 100644
--- a/tox.ini
+++ b/tox.ini
@@ -646,7 +646,6 @@ setenv =
     OBJC_DISABLE_INITIALIZE_FORK_SAFETY=YES
     COVERAGE_FILE=.coverage-{envname}
     django: DJANGO_SETTINGS_MODULE=tests.integrations.django.myapp.settings
-    py3.12-django: PIP_CONSTRAINT=constraints.txt
 
     common: TESTPATH=tests
     gevent: TESTPATH=tests