diff --git a/src/sentry/profiles/profile_chunks.py b/src/sentry/profiles/profile_chunks.py
index 65e3e7cf04f8e1..a89e423e0af246 100644
--- a/src/sentry/profiles/profile_chunks.py
+++ b/src/sentry/profiles/profile_chunks.py
@@ -1,4 +1,6 @@
-from snuba_sdk import Column, Condition, Direction, Op, OrderBy, Query, Request, Storage
+from datetime import datetime
+
+from snuba_sdk import Column, Condition, Direction, Function, Op, OrderBy, Query, Request, Storage
 
 from sentry import options
 from sentry.search.events.types import ParamsType
@@ -20,8 +22,16 @@ def get_chunk_ids(
             Column("chunk_id"),
         ],
         where=[
-            Condition(Column("end_timestamp"), Op.GTE, params.get("start")),
-            Condition(Column("start_timestamp"), Op.LT, params.get("end")),
+            Condition(
+                Column("end_timestamp"),
+                Op.GTE,
+                resolve_datetime64(params.get("start")),
+            ),
+            Condition(
+                Column("start_timestamp"),
+                Op.LT,
+                resolve_datetime64(params.get("end")),
+            ),
             Condition(Column("project_id"), Op.EQ, project_id),
             Condition(Column("profiler_id"), Op.EQ, profiler_id),
         ],
@@ -44,3 +54,23 @@ def get_chunk_ids(
     )
 
     return [row["chunk_id"] for row in result["data"]]
+
+
+def resolve_datetime64(value: datetime | None, precision: int = 6) -> Function | None:
+    # This is normally handled by the snuba-sdk but it assumes that the underlying
+    # table uses DateTime. Because we use DateTime64(6) as the underlying column,
+    # we need to cast to the same type or we risk truncating the timestamp which
+    # can lead to subtle errors.
+
+    if value is None:
+        return None
+
+    if isinstance(value, datetime) and value.tzinfo is not None:
+        # This is adapted from snuba-sdk
+        # See https://github.com/getsentry/snuba-sdk/blob/2f7f014920b4f527a87f18c05b6aa818212bec6e/snuba_sdk/visitors.py#L168-L172
+        delta = value.utcoffset()
+        assert delta is not None
+        value -= delta
+        value.replace(tzinfo=None)
+
+    return Function("toDateTime64", [value.isoformat(), precision])