diff --git a/src/sentry/search/events/datasets/spans_metrics.py b/src/sentry/search/events/datasets/spans_metrics.py
index 50f41e4be6b4a3..37a0aa5eeafb54 100644
--- a/src/sentry/search/events/datasets/spans_metrics.py
+++ b/src/sentry/search/events/datasets/spans_metrics.py
@@ -27,7 +27,10 @@ class Args(TypedDict):
 
 class SpansMetricsDatasetConfig(DatasetConfig):
     missing_function_error = IncompatibleMetricsQuery
-    nullable_metrics = {constants.SPAN_MESSAGING_LATENCY}
+    nullable_metrics = {
+        constants.SPAN_MESSAGING_LATENCY,
+        constants.SPAN_METRICS_MAP["cache.item_size"],
+    }
 
     def __init__(self, builder: spans_metrics.SpansMetricsQueryBuilder):
         self.builder = builder
diff --git a/tests/snuba/api/endpoints/test_organization_events_span_metrics.py b/tests/snuba/api/endpoints/test_organization_events_span_metrics.py
index 96d13a97d5c921..b1a20dd2845adb 100644
--- a/tests/snuba/api/endpoints/test_organization_events_span_metrics.py
+++ b/tests/snuba/api/endpoints/test_organization_events_span_metrics.py
@@ -1741,6 +1741,37 @@ def test_messaging_does_not_exist_as_metric(self):
         meta = response.data["meta"]
         assert meta["fields"]["avg(messaging.message.receive.latency)"] == "null"
 
+    def test_cache_item_size_does_not_exist_as_metric(self):
+        self.store_span_metric(
+            100,
+            internal_metric=constants.SPAN_METRICS_MAP["span.duration"],
+            tags={"cache.item": "true"},
+            timestamp=self.min_ago,
+        )
+        response = self.do_request(
+            {
+                "field": [
+                    "avg(cache.item_size)",
+                    "avg(span.duration)",
+                ],
+                "query": "",
+                "project": self.project.id,
+                "dataset": "spansMetrics",
+                "statsPeriod": "1h",
+            }
+        )
+
+        assert response.status_code == 200, response.content
+        data = response.data["data"]
+        assert data == [
+            {
+                "avg(cache.item_size)": None,
+                "avg(span.duration)": 100,
+            },
+        ]
+        meta = response.data["meta"]
+        assert meta["fields"]["avg(cache.item_size)"] == "null"
+
     def test_trace_status_rate(self):
         self.store_span_metric(
             1,