From b480240433898dd678fb4c9650dd6aee23348bf8 Mon Sep 17 00:00:00 2001 From: Gabriele Girelli Date: Tue, 7 Dec 2021 09:27:32 +0100 Subject: [PATCH] v1.0.1a1 (#14) * Added zenodo shield. * Bump rich from 9.12.0 to 9.12.3 (#11) * Bump rich from 9.12.3 to 9.12.4 (#12) * Bump pandas from 1.2.2 to 1.2.3 (#13) * Added parser functions for HUSH, oligo-melting, and OligoArrayAux * Added assert for dtype compatibility * Added dtypes and expected database columns * Changed entry points for db related actions * Implemented db make script * Added final message. * Cosmetic changes. * Added interface for database-related scripts. * Cleaned * Added basic info script * Added DataBase and Record classes * Simplified using DataBase class. * Prepared to store other information on chromosomes (e.g., record no) * Implemented script to dump tsv to std. * Updated chromosome-related asserts, logs, and properties * Added header printing and tqdm progression * Added chromosome prefix option. Switched from defaultdict to dict for pickling * Added dump description * Added record sorting step. * Added sorted check * Cosmetic * Added ChromosomeData and ChromosomeIndex classes * Added missing declaration and exposed chromosome index * Switched from rich to tqdm. Fixed index visibility in wrappers * Added options for region dumping. * Removed redundant function * Implemented database jumping and window walk * Updated version tag and promoted to beta. Added 3.9 to GHAction. * Added Typed classifier * Linked new database and old walker. * Removed old database module. * Added indexing progress bar * Fixed dump of a region. * Changed default database index bin size to 100 kb * Fixed issue of empty index bins. * Blacked. * Refactored ChromosomeData and added ChromosomeDict class. * Dropped sequence_length column. Fixed pickling of ChromosomeData. * Added reindex entry point. * Bump rich from 9.12.4 to 9.13.0 (#15) * Bump tqdm from 4.58.0 to 4.59.0 (#16) * Split chromosome classes from database. Added docstrings. * Implementing new walker. * Implemented walker with growing focus region. * Moved database walking to walker class * Added tests. * Added test_data to package. * Added pytest setup * Fixed pytest setup * Added pytest to and updated dependencies * Moved GenomicRegion to new region module * Moved pytest and black to dev dependencies * Implemented region builder and multi walk * Implementing new query script * Fixed decoding * Added docstrings * Hidden some prototype code tagged by vulture * Fixed links * Fixed link to repo * Fixed threads check. * Updated version management. * Dropped support for Python 3.7 * Removed default number of queried probes. * Bump rich from 9.13.0 to 10.0.0 (#19) * Bump numpy from 1.20.1 to 1.20.2 (#18) * Bump rich from 10.0.0 to 10.0.1 (#20) * Bump tqdm from 4.59.0 to 4.60.0 (#23) * Bump pytest from 6.2.2 to 6.2.3 (#22) * Bump rich from 10.0.1 to 10.1.0 (#21) * Bump pandas from 1.2.3 to 1.2.4 (#24) * Bump black from 20.8b1 to 21.4b0 (#25) * Bump black from 21.4b0 to 21.4b1 (#26) * Bump black from 21.4b1 to 21.4b2 (#27) * Bump black from 21.4b2 to 21.5b0 (#28) * Bump pytest from 6.2.3 to 6.2.4 (#29) * Bump rich from 10.1.0 to 10.2.0 (#32) * Bump black from 21.5b0 to 21.5b1 (#31) * Bump numpy from 1.20.2 to 1.20.3 (#30) * Bump rich from 10.2.0 to 10.2.2 (#34) * Bump black from 21.5b1 to 21.5b2 (#36) * Bump tqdm from 4.60.0 to 4.61.0 (#35) * Bump rich from 10.2.2 to 10.3.0 (#37) * Bump black from 21.5b2 to 21.6b0 (#38) * Bump tqdm from 4.61.0 to 4.61.1 (#39) * Bump rich from 10.3.0 to 10.4.0 (#40) * Bump pandas from 1.2.4 to 1.2.5 (#41) * Bump numpy from 1.20.3 to 1.21.0 (#42) * Bump pandas from 1.2.5 to 1.3.0 (#43) * Bump rich from 10.4.0 to 10.5.0 (#45) * Bump tqdm from 4.61.1 to 4.61.2 (#44) * Bump rich from 10.5.0 to 10.6.0 (#46) * Bump black from 21.6b0 to 21.7b0 (#47) * Bump numpy from 1.21.0 to 1.21.1 (#48) * Bump tqdm from 4.61.2 to 4.62.0 (#50) * Bump pandas from 1.3.0 to 1.3.1 (#49) * Bump rich from 10.6.0 to 10.7.0 (#51) * Bump tqdm from 4.62.0 to 4.62.1 (#52) * Bump pandas from 1.3.1 to 1.3.2 (#53) * Bump tqdm from 4.62.1 to 4.62.2 (#54) * Bump rich from 10.7.0 to 10.9.0 (#55) * Bump black from 21.7b0 to 21.8b0 (#56) * Bump pytest from 6.2.4 to 6.2.5 (#57) * 'Refactored by Sourcery' (#58) Co-authored-by: Sourcery AI <> * Blacked, flaked, and mypyed * Bump pandas from 1.3.2 to 1.3.3 (#59) * Bump black from 21.8b0 to 21.9b0 (#60) * Bump rich from 10.9.0 to 10.10.0 (#61) * Bump tqdm from 4.62.2 to 4.62.3 (#62) * Bump rich from 10.10.0 to 10.11.0 (#63) * Argparse to click (#65) * Updated dependencies * Preparing for click. * Swapped argparse for click and using dataclasses * 'Refactored by Sourcery' (#66) Co-authored-by: Sourcery AI <> Co-authored-by: sourcery-ai[bot] <58596630+sourcery-ai[bot]@users.noreply.github.com> * Blacked * 'Refactored by Sourcery' (#67) Co-authored-by: Sourcery AI <> * Blacked. * Now passing tests. * Added biopython dependency and extract_kmers script. (#68) * 'Refactored by Sourcery' (#70) Co-authored-by: Sourcery AI <> * Improved extract_kmers script * 'Refactored by Sourcery' (#71) Co-authored-by: Sourcery AI <> * Mypyed after sorcery refactoring * Bump rich from 10.11.0 to 10.12.0 (#72) * Added autocompletion. (#73) * Added autocompletion. * 'Refactored by Sourcery' (#74) Co-authored-by: Sourcery AI <> Co-authored-by: sourcery-ai[bot] <58596630+sourcery-ai[bot]@users.noreply.github.com> * Fixed __path__ * Added missing fasta header starting character * Bump click from 8.0.1 to 8.0.3 (#75) * Added compatibility with previous database pickled arguments. * Added pre-commits. * Fixed spelling * Added support for hush gzipped files * Create .deepsource.toml * Fix comparison constant position (#76) Co-authored-by: deepsource-autofix[bot] <62050782+deepsource-autofix[bot]@users.noreply.github.com> * Replace `dict` call with comprehension (#77) Co-authored-by: deepsource-autofix[bot] <62050782+deepsource-autofix[bot]@users.noreply.github.com> * Remove unnecessary use of comprehension (#78) Co-authored-by: deepsource-autofix[bot] <62050782+deepsource-autofix[bot]@users.noreply.github.com> * Change methods not using its bound instance to staticmethods (#79) Co-authored-by: deepsource-autofix[bot] <62050782+deepsource-autofix[bot]@users.noreply.github.com> * Remove assert statement from non-test files (#80) Co-authored-by: deepsource-autofix[bot] <62050782+deepsource-autofix[bot]@users.noreply.github.com> * Set `check` flag to `True` (#82) Co-authored-by: deepsource-autofix[bot] <62050782+deepsource-autofix[bot]@users.noreply.github.com> * Remove implicit `object` from the base class (#83) Co-authored-by: deepsource-autofix[bot] <62050782+deepsource-autofix[bot]@users.noreply.github.com> * Remove assert statement from non-test files (#84) Co-authored-by: deepsource-autofix[bot] <62050782+deepsource-autofix[bot]@users.noreply.github.com> * Refactor unnecessary `else` / `elif` when `if` block has a `continue` statement (#85) Co-authored-by: deepsource-autofix[bot] <62050782+deepsource-autofix[bot]@users.noreply.github.com> * Refactor unnecessary `else` / `elif` when `if` block has a `return` statement (#86) Co-authored-by: deepsource-autofix[bot] <62050782+deepsource-autofix[bot]@users.noreply.github.com> * Use literal syntax to create data structure (#87) Co-authored-by: deepsource-autofix[bot] <62050782+deepsource-autofix[bot]@users.noreply.github.com> * Merge collapsible `if` statements (#88) Co-authored-by: deepsource-autofix[bot] <62050782+deepsource-autofix[bot]@users.noreply.github.com> * fix: added docstring explaining emptiness. * fix: added docstring explaining emptiness. * Refactor unnecessary `else` / `elif` when `if` block has a `raise` statement (#89) Co-authored-by: deepsource-autofix[bot] <62050782+deepsource-autofix[bot]@users.noreply.github.com> * Remove unnecessary `pass` (#90) Co-authored-by: deepsource-autofix[bot] <62050782+deepsource-autofix[bot]@users.noreply.github.com> * Remove methods with unnecessary super delegation. (#91) Co-authored-by: deepsource-autofix[bot] <62050782+deepsource-autofix[bot]@users.noreply.github.com> * fix: probe selection & unreachable statements * Remove unused private attribute (#92) Co-authored-by: deepsource-autofix[bot] <62050782+deepsource-autofix[bot]@users.noreply.github.com> * fix: Multi-line docstring closing quotes should be on a separate line * fix: swapped single for double quotes * fix: inconsistent return statements * fix: blacked. * fix: process from shell, escaping parameters * fix: inconsistent return statements * fix: removed unused private attribute * fix: escaping shell subprocess cmd * fix: open files with `with` statement * fix: quoted upon subprocess spawning * Merge collapsible `with` statements (#95) Co-authored-by: deepsource-autofix[bot] <62050782+deepsource-autofix[bot]@users.noreply.github.com> * fix: blacked * 'Refactored by Sourcery' (#81) Co-authored-by: Sourcery AI <> * Dropped broken scripts test. * fix: added test placeholder * Bump pandas from 1.3.3 to 1.3.4 (#97) * Bump black from 21.9b0 to 21.10b0 (#98) * Bump rich from 10.12.0 to 10.13.0 (#99) * Bump black from 21.10b0 to 21.11b0 (#100) * Bump rich from 10.13.0 to 10.14.0 (#101) * Bump black from 21.11b0 to 21.11b1 (#102) * fix: wrong condition of path_exists function * fix: correct variable names * fix: assertions on input params * Bump rich from 10.14.0 to 10.15.0 (#103) * Bump rich from 10.15.0 to 10.15.1 (#104) * Bump rich from 10.15.1 to 10.15.2 (#105) * Bump black from 21.11b1 to 21.12b0 (#106) * fix: minor assert change * fix: trove classifier * doc: updated with version flag * docs: updated version flag * feat: updated lock file Co-authored-by: dependabot[bot] <49699333+dependabot[bot]@users.noreply.github.com> Co-authored-by: sourcery-ai[bot] <58596630+sourcery-ai[bot]@users.noreply.github.com> Co-authored-by: deepsource-autofix[bot] <62050782+deepsource-autofix[bot]@users.noreply.github.com> --- .deepsource.toml | 16 + .github/workflows/pythonpackage.yml | 12 +- .pre-commit-config.yaml | 38 + CHANGELOG.md | 17 +- README.md | 8 +- ifpd2/__init__.py | 23 +- ifpd2/asserts.py | 56 +- ifpd2/autocomplete/.ifpd2-complete.bash | 29 + ifpd2/autocomplete/.ifpd2-complete.fish | 22 + ifpd2/autocomplete/.ifpd2-complete.zsh | 35 + ifpd2/chromosome.py | 282 + ifpd2/const.py | 32 +- ifpd2/database.py | 280 +- ifpd2/dataclasses.py | 167 + ifpd2/fasta.py | 34 + ifpd2/io.py | 133 + ifpd2/logging.py | 6 +- ifpd2/oligo.py | 130 +- ifpd2/probe.py | 157 +- ifpd2/probe_set.py | 42 +- ifpd2/region.py | 259 + ifpd2/scripts/__init__.py | 15 +- ifpd2/scripts/arguments.py | 13 +- ifpd2/scripts/autocomplete.py | 92 + ifpd2/scripts/db/__init__.py | 9 + ifpd2/scripts/db/check.py | 33 + ifpd2/scripts/db/dump.py | 78 + ifpd2/scripts/db/info.py | 20 + ifpd2/scripts/db/make.py | 283 + ifpd2/scripts/db/run.py | 23 + ifpd2/scripts/db/settings.py | 102 + ifpd2/scripts/dbchk.py | 41 - ifpd2/scripts/extract_kmers.py | 54 + ifpd2/scripts/ifpd2.py | 54 +- ifpd2/scripts/query.py | 500 +- ifpd2/scripts/query2.py | 261 + ifpd2/tests/__init__.py | 8 + ifpd2/tests/test_scripts_db.py | 8 + ifpd2/walker.py | 212 +- ifpd2/walker2.py | 227 +- ignore-spelling-words.txt | 1 + poetry.lock | 439 +- pyproject.toml | 28 +- test_data/test.dump.txt | 501 + test_data/test.hush.fa | 1000 ++ test_data/test.ss.ct | 20300 ++++++++++++++++++++++ test_data/test.tm.tsv | 501 + test_data/test_db/chr16.bin | Bin 0 -> 49500 bytes test_data/test_db/db.pickle | Bin 0 -> 11146 bytes 49 files changed, 25766 insertions(+), 815 deletions(-) create mode 100644 .deepsource.toml create mode 100644 .pre-commit-config.yaml create mode 100644 ifpd2/autocomplete/.ifpd2-complete.bash create mode 100644 ifpd2/autocomplete/.ifpd2-complete.fish create mode 100644 ifpd2/autocomplete/.ifpd2-complete.zsh create mode 100644 ifpd2/chromosome.py create mode 100644 ifpd2/dataclasses.py create mode 100644 ifpd2/fasta.py create mode 100644 ifpd2/io.py create mode 100644 ifpd2/region.py create mode 100644 ifpd2/scripts/autocomplete.py create mode 100644 ifpd2/scripts/db/__init__.py create mode 100644 ifpd2/scripts/db/check.py create mode 100644 ifpd2/scripts/db/dump.py create mode 100644 ifpd2/scripts/db/info.py create mode 100644 ifpd2/scripts/db/make.py create mode 100644 ifpd2/scripts/db/run.py create mode 100644 ifpd2/scripts/db/settings.py delete mode 100644 ifpd2/scripts/dbchk.py create mode 100644 ifpd2/scripts/extract_kmers.py create mode 100644 ifpd2/scripts/query2.py create mode 100644 ifpd2/tests/__init__.py create mode 100644 ifpd2/tests/test_scripts_db.py create mode 100644 ignore-spelling-words.txt create mode 100644 test_data/test.dump.txt create mode 100644 test_data/test.hush.fa create mode 100644 test_data/test.ss.ct create mode 100644 test_data/test.tm.tsv create mode 100644 test_data/test_db/chr16.bin create mode 100644 test_data/test_db/db.pickle diff --git a/.deepsource.toml b/.deepsource.toml new file mode 100644 index 00000000..7e92eaec --- /dev/null +++ b/.deepsource.toml @@ -0,0 +1,16 @@ +version = 1 + +[[analyzers]] +name = "shell" +enabled = true + +[[analyzers]] +name = "secrets" +enabled = true + +[[analyzers]] +name = "python" +enabled = true + + [analyzers.meta] + runtime_version = "3.x.x" diff --git a/.github/workflows/pythonpackage.yml b/.github/workflows/pythonpackage.yml index 19078fa3..2b5702dc 100644 --- a/.github/workflows/pythonpackage.yml +++ b/.github/workflows/pythonpackage.yml @@ -37,7 +37,7 @@ jobs: fail-fast: true matrix: os: ["ubuntu-latest"] - python-version: [3.7, 3.8] + python-version: [3.8, 3.9] runs-on: ${{ matrix.os }} steps: # Checkout repo and setup python @@ -62,8 +62,8 @@ jobs: - name: Install dependencies run: poetry install if: steps.cached-poetry-dependencies.outputs.cache-hit != 'true' - # run test suite - # - name: Test - # run: | - # source .venv/bin/activate - # pytest radiantkit/tests/ + # run: test suite + - name: Test + run: | + source .venv/bin/activate + pytest ifpd2/tests/ diff --git a/.pre-commit-config.yaml b/.pre-commit-config.yaml new file mode 100644 index 00000000..4e59a592 --- /dev/null +++ b/.pre-commit-config.yaml @@ -0,0 +1,38 @@ +# See https://pre-commit.com for more information +# See https://pre-commit.com/hooks.html for more hooks +default_language_version: + python: python3.8 +repos: +- repo: https://github.com/pre-commit/pre-commit-hooks + rev: "v4.0.1" + hooks: + - id: check-added-large-files + - id: check-ast + - id: check-docstring-first + - id: check-yaml +- repo: https://github.com/pre-commit/mirrors-mypy + rev: "v0.910-1" + hooks: + - id: mypy +- repo: https://github.com/psf/black + rev: "21.9b0" + hooks: + - id: black +- repo: https://github.com/PyCQA/flake8 + rev: "4.0.1" + hooks: + - id: flake8 + args: ["--count", "--select=E9,F63,F7,F82", "--show-source", "--statistics"] + - id: flake8 + args: ["--count", "--exit-zero", "--max-complexity=5", "--max-line-length=88", "--ignore=E203", "--statistics"] +- repo: https://github.com/jendrikseipp/vulture + rev: "v2.3" + hooks: + - id: vulture +- repo: https://github.com/codespell-project/codespell + rev: v2.1.0 + hooks: + - id: codespell + entry: codespell --ignore-words=ignore-spelling-words.txt + language: python + types: [text] \ No newline at end of file diff --git a/CHANGELOG.md b/CHANGELOG.md index 7836eca2..a3b1a4d3 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -7,9 +7,20 @@ and this project adheres to [Semantic Versioning](http://semver.org/spec/v2.0.0. ## Unreleased -### ... -- ... + +## [1.0.1a1] - 2021-12-07 +### Added +- New entry points: `db make`, `db dump`, `db info`, `db merge`, and `db_reindex`. +- Module `io` with parsing functions for output generated via oligo-melting, hush, or OligoArrayAux. +- Assert for compatibility with a given dtype. (only max value currently checked) + +### Changed +- New database format. +- `dbchk` entry point changed to `db check`. +- Dropped sequence length column, as it can be inferred from the end/start columns. +- Removed `-X` default from `query`. ## [1.0.0-alpha] - 2021-02-26 -[1.0.0-alpha] https://github.com/ggirelli/ifpd/releases/tag/v1.0.0-alpha +[1.0.1a1] https://github.com/ggirelli/ifpd2/releases/tag/v1.0.1a1 +[1.0.0-alpha] https://github.com/ggirelli/ifpd2/releases/tag/v1.0.0-alpha diff --git a/README.md b/README.md index c52cc601..1339734a 100644 --- a/README.md +++ b/README.md @@ -1,19 +1,19 @@ # iFISH Probe Design (II) -![](https://img.shields.io/github/license/ggirelli/ifpd2.svg?style=flat) ![](https://github.com/ggirelli/ifpd2/workflows/Python%20package/badge.svg?branch=main&event=push) +[![DOI](https://zenodo.org/badge/210782569.svg)](https://zenodo.org/badge/latestdoi/210782569) ![](https://img.shields.io/github/license/ggirelli/ifpd2.svg?style=flat) ![](https://github.com/ggirelli/ifpd2/workflows/Python%20package/badge.svg?branch=main&event=push) ![PyPI - Python Version](https://img.shields.io/pypi/pyversions/ifpd2) ![PyPI - Format](https://img.shields.io/pypi/format/ifpd2) ![PyPI - Status](https://img.shields.io/pypi/status/ifpd2) ![](https://img.shields.io/github/release/ggirelli/ifpd2.svg?style=flat) ![](https://img.shields.io/github/release-date/ggirelli/ifpd2.svg?style=flat) ![](https://img.shields.io/github/languages/code-size/ggirelli/ifpd2.svg?style=flat) ![](https://img.shields.io/github/watchers/ggirelli/ifpd2.svg?label=Watch&style=social) ![](https://img.shields.io/github/stars/ggirelli/ifpd2.svg?style=social) [PyPi](https://pypi.org/project/ifpd2/) | [docs](https://ggirelli.github.io/ifpd2/) -`ifpd2` is a Python3.7+ package containing tools for selection of complementary oligonucleotides to build iFISH probes. It is based on our previous `ifpd` package, but works with a different and more detailed database format, allowing for more precise control on the probe design process. Read the online [documentation](https://ggirelli.github.io/ifpd2/) for more details. +`ifpd2` is a Python3.8+ package containing tools for selection of complementary oligonucleotides to build iFISH probes. It is based on our previous `ifpd` package, but works with a different and more detailed database format, allowing for more precise control on the probe design process. Read the online [documentation](https://ggirelli.github.io/ifpd2/) for more details. ## Requirements -`ifpd2` is fully implemented in Python3.7+, thus you need the corresponding Python version to run it. Check out [here](https://realpython.com/installing-python/) how to install Python+ on your machine if you don't have it yet. +`ifpd2` is fully implemented in Python3.8+, thus you need the corresponding Python version to run it. Check out [here](https://realpython.com/installing-python/) how to install Python+ on your machine if you don't have it yet. -`ifpd2` has been tested with Python 3.7 and 3.8. We recommend installing it using `pipx` (see [below](https://github.com/ggirelli/ifpd2#installation)) to avoid dependency conflicts with other packages. The packages it depends on are listed in our [dependency graph](https://github.com/ggirelli/ifpd2/network/dependencies). We use [`poetry`](https://github.com/python-poetry/poetry) to handle our dependencies. +`ifpd2` has been tested with Python 3.8 and 3.9. We recommend installing it using `pipx` (see [below](https://github.com/ggirelli/ifpd2#installation)) to avoid dependency conflicts with other packages. The packages it depends on are listed in our [dependency graph](https://github.com/ggirelli/ifpd2/network/dependencies). We use [`poetry`](https://github.com/python-poetry/poetry) to handle our dependencies. ## Installation diff --git a/ifpd2/__init__.py b/ifpd2/__init__.py index 1b072e32..99151f66 100644 --- a/ifpd2/__init__.py +++ b/ifpd2/__init__.py @@ -3,17 +3,32 @@ @contact: gigi.ga90@gmail.com """ -from ifpd2.const import __version__ -from ifpd2 import asserts -from ifpd2 import database, walker +from ifpd2 import asserts, dataclasses, fasta, io +from ifpd2 import walker, walker2 +from ifpd2 import chromosome, database, region from ifpd2 import oligo, probe, probe_set +from importlib.metadata import version, PackageNotFoundError +from typing import List + +try: + __version__ = version(__name__) +except PackageNotFoundError: + pass + __all__ = [ "__version__", "asserts", - "database", + "dataclasses", + "fasta", + "io", "walker", + "walker2", + "chromosome", + "database", + "region", "oligo", "probe", "probe_set", ] +__path__: List[str] diff --git a/ifpd2/asserts.py b/ifpd2/asserts.py index 10985649..93c67cc0 100644 --- a/ifpd2/asserts.py +++ b/ifpd2/asserts.py @@ -4,37 +4,67 @@ """ import logging +import numpy as np # type: ignore import sys from typing import Callable def ert_type(x, stype, label): - assert isinstance(x, stype), f"{label} should be {stype}, {type(x)} instead" + if not isinstance(x, stype): + raise AssertionError(f"{label} should be {stype}, {type(x)} instead") def ert_multiTypes(x, types, label): - cond = any([isinstance(x, t) for t in types]) - assert cond, f"{label} should be one of {types}, {type(x)} instead" + cond = any(isinstance(x, t) for t in types) + if not cond: + raise AssertionError(f"{label} should be one of {types}, {type(x)} instead") def ert_nonNeg(x, label, include_zero=False): if not include_zero: - assert x > 0, f"{label} should be greater than 0" - else: - assert x >= 0, f"{label} should be greater than or equal to 0" + if x <= 0: + raise AssertionError(f"{label} should be greater than 0") + elif x < 0: + raise AssertionError(f"{label} should be greater than or equal to 0") def ert_inInterv(x, vmin, vmax, label, leftClose=False, rightClose=True): if leftClose: if rightClose: - assert x >= vmin and x <= vmax, f"expected {vmin}<={label}<={vmax}" - else: - assert x >= vmin and x < vmax, f"expected {vmin}<={label}<{vmax}" + if x < vmin or x > vmax: + raise AssertionError(f"expected {vmin}<={label}<={vmax}") + elif x < vmin or x >= vmax: + raise AssertionError(f"expected {vmin}<={label}<{vmax}") + elif rightClose: + if x <= vmin or x > vmax: + raise AssertionError(f"expected {vmin}<{label}<={vmax}") + elif x <= vmin or x >= vmax: + raise AssertionError(f"expected {vmin}<{label}<{vmax}") + + +def ert_in_dtype(x, dtype): + if dtype.startswith("f"): + if x > np.finfo(dtype).max: + raise AssertionError( + " ".join( + [ + "expected to be lower than {dtype} max:", + f"{x} < {np.finfo(dtype).max}", + ] + ) + ) + elif dtype.startswith("u") or dtype.startswith("i"): + if x > np.iinfo(dtype).max: + raise AssertionError( + " ".join( + [ + "expected to be lower than {dtype} max:", + f"{x} < {np.iinfo(dtype).max}", + ] + ) + ) else: - if rightClose: - assert x > vmin and x <= vmax, f"expected {vmin}<{label}<={vmax}" - else: - assert x > vmin and x < vmax, f"expected {vmin}<{label}<{vmax}" + logging.warning(f"assert not implemented for dtype '{dtype}'") def enable_rich_assert(fun: Callable) -> Callable: diff --git a/ifpd2/autocomplete/.ifpd2-complete.bash b/ifpd2/autocomplete/.ifpd2-complete.bash new file mode 100644 index 00000000..f045cfc9 --- /dev/null +++ b/ifpd2/autocomplete/.ifpd2-complete.bash @@ -0,0 +1,29 @@ +_ifpd2_completion() { + local IFS=$'\n' + local response + + response=$(env COMP_WORDS="${COMP_WORDS[*]}" COMP_CWORD=$COMP_CWORD _IFPD2_COMPLETE=bash_complete $1) + + for completion in $response; do + IFS=',' read type value <<< "$completion" + + if [[ $type == 'dir' ]]; then + COMREPLY=() + compopt -o dirnames + elif [[ $type == 'file' ]]; then + COMREPLY=() + compopt -o default + elif [[ $type == 'plain' ]]; then + COMPREPLY+=($value) + fi + done + + return 0 +} + +_ifpd2_completion_setup() { + complete -o nosort -F _ifpd2_completion ifpd2 +} + +_ifpd2_completion_setup; + diff --git a/ifpd2/autocomplete/.ifpd2-complete.fish b/ifpd2/autocomplete/.ifpd2-complete.fish new file mode 100644 index 00000000..075e65ff --- /dev/null +++ b/ifpd2/autocomplete/.ifpd2-complete.fish @@ -0,0 +1,22 @@ +function _ifpd2_completion; + set -l response; + + for value in (env _IFPD2_COMPLETE=fish_complete COMP_WORDS=(commandline -cp) COMP_CWORD=(commandline -t) ifpd2); + set response $response $value; + end; + + for completion in $response; + set -l metadata (string split "," $completion); + + if test $metadata[1] = "dir"; + __fish_complete_directories $metadata[2]; + else if test $metadata[1] = "file"; + __fish_complete_path $metadata[2]; + else if test $metadata[1] = "plain"; + echo $metadata[2]; + end; + end; +end; + +complete --no-files --command ifpd2 --arguments "(_ifpd2_completion)"; + diff --git a/ifpd2/autocomplete/.ifpd2-complete.zsh b/ifpd2/autocomplete/.ifpd2-complete.zsh new file mode 100644 index 00000000..b68c1464 --- /dev/null +++ b/ifpd2/autocomplete/.ifpd2-complete.zsh @@ -0,0 +1,35 @@ +#compdef ifpd2 + +_ifpd2_completion() { + local -a completions + local -a completions_with_descriptions + local -a response + (( ! $+commands[ifpd2] )) && return 1 + + response=("${(@f)$(env COMP_WORDS="${words[*]}" COMP_CWORD=$((CURRENT-1)) _IFPD2_COMPLETE=zsh_complete ifpd2)}") + + for type key descr in ${response}; do + if [[ "$type" == "plain" ]]; then + if [[ "$descr" == "_" ]]; then + completions+=("$key") + else + completions_with_descriptions+=("$key":"$descr") + fi + elif [[ "$type" == "dir" ]]; then + _path_files -/ + elif [[ "$type" == "file" ]]; then + _path_files -f + fi + done + + if [ -n "$completions_with_descriptions" ]; then + _describe -V unsorted completions_with_descriptions -U + fi + + if [ -n "$completions" ]; then + compadd -U -V unsorted -a completions + fi +} + +compdef _ifpd2_completion ifpd2; + diff --git a/ifpd2/chromosome.py b/ifpd2/chromosome.py new file mode 100644 index 00000000..e176cf1d --- /dev/null +++ b/ifpd2/chromosome.py @@ -0,0 +1,282 @@ +""" +@author: Gabriele Girelli +@contact: gigi.ga90@gmail.com +""" + +import copy +from ifpd2 import const +from ifpd2.io import get_dtype_length +import numpy as np # type: ignore +import pandas as pd # type: ignore +from rich.progress import Progress, TaskID # type: ignore +from typing import Dict, List, Set, Tuple + + +class ChromosomeIndex: + """ChromosomeIndex""" + + _bin_size: int + _index: Dict[int, Tuple[float, float]] + + def __init__(self, bin_size: int): + super(ChromosomeIndex, self).__init__() + if bin_size < 1: + raise AssertionError + self._bin_size = bin_size + + def __init_index(self, chrom_db: pd.DataFrame) -> None: + """Initialize chromosome index + + Creates an chromosome index with empty bins. + + Arguments: + chrom_db {pd.DataFrame} -- chromosome database + """ + self._index = {} + chrom_size_nt = chrom_db["end"].values.max() + for bin_id in range((chrom_size_nt // self._bin_size) + 1): + self._index[bin_id] = (np.inf, 0) + + @property + def bin_size(self) -> int: + return self._bin_size + + @property + def data(self) -> Dict[int, Tuple[float, float]]: + return copy.copy(self._index) + + def __populate_bins( + self, + chrom_db: pd.DataFrame, + record_byte_size: int, + track: Tuple[Progress, TaskID], + ) -> None: + """Populate bins. + + Add extremities (byte positions) of each bin. + + Arguments: + chrom_db {pd.DataFrame} -- chromosome database + record_byte_size {int} -- size of a record in bytes (based on column dtype) + track {Tuple[Progress, TaskID]} -- progress bar details + """ + current_position = -1 + for i in range(chrom_db.shape[0]): + track[0].update(track[1], advance=1) + position_in_nt = chrom_db["start"].values[i] + if position_in_nt <= current_position: + raise AssertionError + current_position = position_in_nt + + position_in_bytes = record_byte_size * i + binned_to = position_in_nt // self._bin_size + + bin_start, bin_end = list(self._index[binned_to]) + bin_start = min(bin_start, position_in_bytes) + bin_end = max(bin_end, position_in_bytes) + self._index[binned_to] = (bin_start, bin_end) + + def __fill_empty_bins(self) -> None: + """Populate empty bins of the index.""" + if not np.isfinite(self._index[0][0]): + self._index[0] = (0, 0) + for bin_id, (start, end) in self._index.items(): + if not np.isfinite(start): + self._index[bin_id] = ( + self._index[bin_id - 1][1], + self._index[bin_id - 1][1], + ) + + def build( + self, + chrom_db: pd.DataFrame, + record_byte_size: int, + track: Tuple[Progress, TaskID], + ) -> None: + """Build chromosome index. + + [description] + + Arguments: + chrom_db {pd.DataFrame} -- chromosome database + record_byte_size {int} -- size of a record in bytes (based on column dtype) + track {Tuple[Progress, TaskID]} -- progress bar details + """ + for colname in ("chromosome", "start", "end"): + if colname not in chrom_db.columns: + raise AssertionError(f"missing '{colname}' column") + chromosome_set: Set[bytes] = set(chrom_db["chromosome"].values) + if len(chromosome_set) != 1: + raise AssertionError + + self.__init_index(chrom_db) + self.__populate_bins(chrom_db, record_byte_size, track) + self.__fill_empty_bins() + + def __getitem__(self, position_in_nt: int) -> int: + if self._index is None: + raise AssertionError + binned_to = position_in_nt // self._bin_size + if binned_to not in self._index: + return -1 + + position_in_bytes = int(self._index[binned_to][0]) + if not np.isfinite(position_in_bytes): + return -1 + return position_in_bytes + + def __eq__(self, other) -> bool: + condition = self.bin_size == other.bin_size + condition = condition and self.data == other.data + return condition + + +class ChromosomeData: + """Contains information on a chromosome""" + + _name: bytes + _size_nt: int + _size_bytes: int + _recordno: int + _index: ChromosomeIndex + _record_byte_size: int + + def __init__( + self, + chromosome_db: pd.DataFrame, + dtype: Dict[str, str], + index_bin_size: int, + progress: Progress, + ): + super(ChromosomeData, self).__init__() + + if "chromosome" not in chromosome_db.columns: + raise AssertionError + selected_chrom = chromosome_db["chromosome"][0] + if len(set(chromosome_db["chromosome"].values)) != 1: + raise AssertionError + + self._record_byte_size = get_dtype_length(dtype) + if self._record_byte_size <= 0: + raise AssertionError + + self._name = selected_chrom + self._recordno = chromosome_db.shape[0] + self._size_nt = chromosome_db["end"].values.max() + self._size_bytes = chromosome_db.shape[0] * self._record_byte_size + + self._build_index(chromosome_db, index_bin_size, progress) + + @property + def name(self) -> bytes: + return self._name + + @property + def record_byte_size(self) -> int: + return self._record_byte_size + + @property + def size_nt(self) -> int: + return self._size_nt + + @property + def size_bytes(self) -> int: + return self._size_bytes + + @property + def recordno(self) -> int: + return self._recordno + + @property + def index(self) -> ChromosomeIndex: + return copy.copy(self._index) + + def _build_index( + self, chromosome_db: pd.DataFrame, index_bin_size: int, progress: Progress + ) -> None: + """Build a chromosome index. + + Build bin index based on chromosome length and bin size. + + Arguments: + chromosome_db {pd.DataFrame} -- chromosome database + index_bin_size {int} -- index bin size + progress {Progress} -- progress instance for progress bar with rich + """ + if index_bin_size <= 0: + raise AssertionError + indexing_track = progress.add_task( + f"indexing {self._name.decode()}.bin", + total=chromosome_db.shape[0], + transient=True, + ) + self._index = ChromosomeIndex(index_bin_size) + self._index.build( + chromosome_db, self._record_byte_size, (progress, indexing_track) + ) + progress.remove_task(indexing_track) + + def __eq__(self, other) -> bool: + condition = self.record_byte_size == other.record_byte_size + condition = condition and self.size_nt == other.size_nt + condition = condition and self.size_bytes == other.size_bytes + condition = condition and self.recordno == other.recordno + condition = condition and self.index == other.index + return condition + + +class ChromosomeDict: + """Wraps ChromosomeData instances into a dictionary + and allow easier access to their attributes. + """ + + _index_bin_size: int + _data: Dict[bytes, ChromosomeData] + + def __init__(self, index_bin_size: int = const.DEFAULT_DATABASE_INDEX_BIN_SIZE): + super(ChromosomeDict, self).__init__() + self._data = {} + if index_bin_size <= 0: + raise AssertionError + self._index_bin_size = index_bin_size + + def __len__(self) -> int: + return len(self._data) + + def keys(self) -> List[bytes]: + return list(self._data.keys()) + + def items(self) -> List[Tuple[bytes, ChromosomeData]]: + return list(self._data.items()) + + @property + def index_bin_size(self) -> int: + return self._index_bin_size + + @property + def sizes_nt(self) -> Dict[bytes, int]: + return {name: data.size_nt for name, data in self._data.items()} + + @property + def sizes_bytes(self) -> Dict[bytes, int]: + return {name: data.size_bytes for name, data in self._data.items()} + + @property + def recordnos(self) -> Dict[bytes, int]: + return {name: data.recordno for name, data in self._data.items()} + + def get_chromosome(self, chromosome: bytes) -> ChromosomeData: + return copy.copy(self._data[chromosome]) + + def add_chromosome( + self, chromosome_db: pd.DataFrame, dtype: Dict[str, str], progress: Progress + ) -> None: + self._data[chromosome_db["chromosome"][0]] = ChromosomeData( + chromosome_db, dtype, self._index_bin_size, progress + ) + + def __eq__(self, other) -> bool: + condition = len(self) == len(other) + condition = condition and self.items() == other.items() + condition = condition and self.index_bin_size == other.index_bin_size + return condition diff --git a/ifpd2/const.py b/ifpd2/const.py index a8840f40..7303f5d2 100644 --- a/ifpd2/const.py +++ b/ifpd2/const.py @@ -3,4 +3,34 @@ @contact: gigi.ga90@gmail.com """ -__version__ = "1.0.0-alpha" +CONTEXT_SETTINGS = dict(help_option_names=["-h", "--help"]) + +dtype_melting = { + "name": "|S", + "Tm_dG": " Dict[str, Any]: + return copy.copy(self._data) + + def __parse_bytes(self, record: bytes, column_dtypes: Dict[str, str]) -> None: + """Parse record bytes. + + Parses a record from its bytes based on column dtypes. + + Arguments: + record {bytes} -- record bytes + column_dtypes {Dict[str, str]} -- column dtypes + """ + if len(record) != get_dtype_length(column_dtypes): + raise AssertionError + self._data = {} + current_location = 0 + for label in const.database_columns: + dtype = column_dtypes[label] + byte_size = get_dtype_length({label: dtype}) + self._data[label] = np.frombuffer( + record[current_location : (current_location + byte_size)], dtype + )[0] + current_location += byte_size + + def to_dataframe(self) -> pd.DataFrame: + return pd.DataFrame(self._data, index=[0]) + + def to_csv(self, sep: str = ",") -> str: + csv_fields: List[str] = [] + for x in const.database_columns: + data = self._data[x] + if isinstance(data, bytes): + csv_fields.append(str(data.decode())) + else: + csv_fields.append(str(data)) + return sep.join(csv_fields) + + @staticmethod + def __norm_value_in_range(v, r): + if r[1] == 0: + return np.nan + return (v - r[0]) / (r[1] - r[0]) + + def __update_score_by_nOT(self, F): + off_target_no = self._data["off_target_no"] + if off_target_no <= F[0]: + self._data["score"] = 0 + return None + if off_target_no > F[1]: + self._data["score"] = np.inf + return None + return self.__norm_value_in_range(off_target_no, F) + + def __update_score_by_dG_Tm(self, Gs): + ss_dG = self._data["ss_dG"] + tm_dG = self._data["Tm_dG"] + if ss_dG >= tm_dG * min(Gs): + self._data["score"] = 0 + return None + if ss_dG < tm_dG * max(Gs): + self._data["score"] = np.inf + return None + return self.__norm_value_in_range(ss_dG, [tm_dG * f for f in Gs]) + + def __update_score_by_dG_Gs(self, Gs): + ss_dG = self._data["ss_dG"] + if ss_dG >= Gs[0]: + self._data["score"] = 0 + return None + if ss_dG < Gs[1]: + self._data["score"] = np.inf + return None + return self.__norm_value_in_range(ss_dG, Gs) + + def add_score(self, F, Gs) -> None: + norm_nOT = self.__update_score_by_nOT(F) + if norm_nOT is None: + return None + if all(x >= 0 for x in Gs): + norm_ss_dG = self.__update_score_by_dG_Tm(Gs) + else: + norm_ss_dG = self.__update_score_by_dG_Gs(Gs) + if norm_ss_dG is None: + return None + self._data["score"] = np.mean([norm_nOT, norm_ss_dG]) + return None + + def __getitem__(self, key: str) -> Any: + allowed_columns = ["score", *const.database_columns] + if key not in allowed_columns: + raise KeyError(f"unrecognized key '{key}'") + return self.data[key] + + def __repr__(self) -> str: + return str(self._data) + + +class DataBase: + """Buffering and checking class for ifpd2 database.""" + + _root: str + _args: Dict[str, Any] + _chromosomes: ChromosomeDict + _dtype: Dict[str, str] + _record_byte_size: int + + def __init__(self, path: str): + """ + Arguments: + path {str} -- absolute path to database folder + """ + super(DataBase, self).__init__() + if not os.path.isdir(path): + raise AssertionError(f"cannot find database folder '{path}'") + db_pickle_path = os.path.join(path, "db.pickle") + if not os.path.isfile(db_pickle_path): + raise AssertionError(f"'db.pickle is missing in '{path}'") + + with open(db_pickle_path, "rb") as IH: + details = pickle.load(IH) + self._chromosomes = details["chromosomes"] + self._dtype = details["dtype"] + if isinstance(details["args"], argparse.Namespace): + self._args = self.__parse_old_pickle(details["args"]) + else: + self._args = dict(details["args"]) + + if not isinstance(self._chromosomes, ChromosomeDict): + raise AssertionError + for chromosome in self.chromosome_list: + chromosome_path = os.path.join(path, f"{chromosome.decode()}.bin") + if not os.path.isfile(chromosome_path): + raise AssertionError( + f"missing expected chromosome file: '{chromosome_path}'" + ) + + self._record_byte_size = get_dtype_length(self._dtype) + if self._record_byte_size <= 0: + raise AssertionError + + self._root = path @property - def dtype(self): - return self._dtype + def path(self): + return self._root @property - def n_expected_fields(self): - return self._n_expected_fields + def chromosome_list(self) -> List[bytes]: + return self._chromosomes.keys() @property - def n_bytes(self): - return self._n_bytes + def chromosome_sizes_nt(self) -> Dict[bytes, int]: + return self._chromosomes.sizes_nt + + # @property + # def chromosome_sizes_bytes(self) -> Dict[bytes, int]: + # return self._chromosomes.sizes_bytes @property - def N(self): - return self._N + def chromosome_recordnos(self) -> Dict[bytes, int]: + return self._chromosomes.recordnos @property - def c(self): - return self._c + def record_byte_size(self) -> int: + return self._record_byte_size @property - def k(self): - return self._k - - def __check_integrity(self): - assert_msg = f"Database at '{self.path}' does not pass integrity check." - config_path = os.path.join(self.path, ".config") - assert os.path.isfile(config_path), assert_msg - config = cp.ConfigParser() - config.read(config_path) - assert "IFPD2DB" in config.keys(), assert_msg - assert "namelen" in config["IFPD2DB"].keys(), assert_msg - assert "chromlen" in config["IFPD2DB"].keys(), assert_msg - assert "oligok" in config["IFPD2DB"].keys(), assert_msg - self._N = config["IFPD2DB"].getint("namelen") - self._c = config["IFPD2DB"].getint("chromlen") - self._k = config["IFPD2DB"].getint("oligok") - self._dtype = f"{self.N}s {self.c}s i i f f f f {self.k}s i i f f" - self._n_expected_fields = len(self.dtype.split(" ")) - self._n_bytes = struct.calcsize(self.dtype) - - def buffer(self, chrom): - chrom_path = os.path.join(self.path, f"{chrom}.bin") - if not os.path.isfile(chrom_path): - return - with open(chrom_path, "rb") as DBH: - bytepack = DBH.read(self.n_bytes) - while 0 != len(bytepack): - yield struct.unpack(self.dtype, bytepack) - bytepack = DBH.read(self.n_bytes) + def dtype(self) -> Dict[str, str]: + return copy.copy(self._dtype) + + @staticmethod + def __parse_old_pickle(args: argparse.Namespace) -> Dict[str, Any]: + _args = vars(args) + return dict( + output_path=_args["output"], + off_target_paths=_args["hush"], + melting_temperature_paths=_args["melting"], + secondary_structure_paths=_args["secondary"], + bin_size=_args["binsize"], + prefix=_args["prefix"], + ) + + def get_chromosome(self, chromosome: bytes) -> ChromosomeData: + return self._chromosomes.get_chromosome(chromosome) + + def log_details(self) -> None: + """Log database details.""" + logging.info(f"Database name: {self._args['output_path']}") + logging.info(f"Sequence max length: {self._dtype['sequence'][2:]}") + logging.info("") + logging.info("[bold]## Input files[/bold]") + logging.info(f"hush files: {self._args['off_target_paths']}") + logging.info(f"oligo-melting files: {self._args['melting_temperature_paths']}") + logging.info(f"OligoArrayAux files: {self._args['secondary_structure_paths']}") + logging.info("") + logging.info("[bold]## Chromosome details[/bold]") + logging.info(f"Expecting {len(self._chromosomes)} chromosomes.") + logging.info("Chromosomes:") + for chromosome, data in self._chromosomes.items(): + empty_label = "".join(" " for c in chromosome.decode()) + logging.info(f"\t{chromosome.decode()} => size : {data.size_nt} (nt)") + logging.info(f"\t{chromosome.decode()} => size : {data.size_bytes} (bytes)") + logging.info(f"\t{empty_label} => recordno : {data.recordno}") + logging.info("") + logging.info("[bold]Record details[/bold]") + logging.info(f"Record size in bytes: {self._record_byte_size}") + logging.info(f"Dtype: {self._dtype}") diff --git a/ifpd2/dataclasses.py b/ifpd2/dataclasses.py new file mode 100644 index 00000000..ca84bf0c --- /dev/null +++ b/ifpd2/dataclasses.py @@ -0,0 +1,167 @@ +""" +@author: Gabriele Girelli +@contact: gigi.ga90@gmail.com +""" + +from dataclasses import dataclass +from os.path import isdir, isfile +from typing import Optional, Tuple + + +def path_exists(path: str) -> bool: + return isdir(path) or isfile(path) + + +@dataclass(frozen=True) +class Folder: + path: str + exists: bool = False + + def __post_init__(self): + if ( + self.exists + and not isdir(self.path) + or not self.exists + and path_exists(self.path) + ): + raise AssertionError((self.path, self.exists)) + + +@dataclass(frozen=True) +class File: + path: str + exists: bool = False + + def __post_init__(self): + if ( + self.exists + and not isfile(self.path) + or not self.exists + and path_exists(self.path) + ): + raise AssertionError + + +@dataclass(frozen=True) +class PositiveInteger: + n: int + + def __post_init__(self): + if self.n < 1: + raise AssertionError + + +@dataclass(frozen=True) +class NonNegativeFloat: + n: float + + def __post_init__(self): + if self.n < 0: + raise AssertionError + + +@dataclass(frozen=True) +class NonNegativeInteger: + n: int + + def __post_init__(self): + if self.n <= 0: + raise AssertionError + + +@dataclass(frozen=True) +class PositiveFloat: + n: float + limit: Optional[float] = None + limit_included: bool = True + + def __post_init__(self): + if self.limit is None: + if self.n <= 0: + raise AssertionError + + elif self.limit_included: + if not 0 < self.n <= self.limit: + raise AssertionError + elif not 0 < self.n < self.limit: + raise AssertionError + + +@dataclass(frozen=True) +class GenomicRegion: + start: int + end: int + + def __post_init__(self): + if self.start < 0: + raise AssertionError + if self.end < self.start and self.end != -1: + raise AssertionError + + def astuple(self) -> Tuple[int, int]: + return (self.start, self.end) + + +@dataclass(frozen=True) +class NonNegativeIntInterval: + start: int + end: int + + def __post_init__(self): + if self.start < 0: + raise AssertionError + if self.end < self.start: + raise AssertionError + + def astuple(self) -> Tuple[int, int]: + return (self.start, self.end) + + +@dataclass(frozen=True) +class QueryWindow: + size: Optional[int] + shift: Optional[float] + + def __post_init__(self): + if self.size is not None and self.size < 1: + raise AssertionError + if not 0 < self.shift <= 1: + raise AssertionError + + def astuple(self) -> Tuple[Optional[int], Optional[float]]: + return (self.size, self.shift) + + +@dataclass(frozen=True) +class QueryFocus: + size: float + step: float + + def __post_init__(self): + if self.size <= 0: + raise AssertionError + if self.step <= 0: + raise AssertionError + + +@dataclass(frozen=True) +class FreeEnergyInterval: + start: float + end: float + + def astuple(self) -> Tuple[float, float]: + return (self.start, self.end) + + +@dataclass(frozen=True) +class GCRange: + low: float + high: float + + def __post_init__(self): + if not 0 <= self.low <= 1: + raise AssertionError + if not 0 <= self.high <= 1: + raise AssertionError + if self.low > self.high: + raise AssertionError diff --git a/ifpd2/fasta.py b/ifpd2/fasta.py new file mode 100644 index 00000000..2334cc02 --- /dev/null +++ b/ifpd2/fasta.py @@ -0,0 +1,34 @@ +""" +@author: Gabriele Girelli +@contact: gigi.ga90@gmail.com +""" + +from Bio.SeqIO.FastaIO import SimpleFastaParser # type: ignore +from os.path import isfile +from tqdm import tqdm # type: ignore +from typing import List, Tuple + + +def extract_kmers(input_path: str, kmer_size: int) -> List[Tuple[str, str]]: + if not isfile(input_path): + raise AssertionError + with open(input_path) as FH: + oligos_list: List[Tuple[str, str]] = [] + for record_header, record_sequence in tqdm( + SimpleFastaParser(FH), desc="Parsing region", leave=False + ): + for i in tqdm( + range(len(record_sequence) - kmer_size + 1), + desc="Extracting oligos", + leave=False, + ): + oligo_sequence = str(record_sequence)[slice(i, i + kmer_size)] + if "N" in oligo_sequence: + continue + oligos_list.append( + ( + f"{record_header}|{i+1}:{i+kmer_size+1}", + oligo_sequence, + ) + ) + return oligos_list diff --git a/ifpd2/io.py b/ifpd2/io.py new file mode 100644 index 00000000..b61e85fe --- /dev/null +++ b/ifpd2/io.py @@ -0,0 +1,133 @@ +""" +@author: Gabriele Girelli +@contact: gigi.ga90@gmail.com +""" + +import copy +from ifpd2 import asserts as ass +from ifpd2 import const +import gzip +import logging +import os +import pandas as pd # type: ignore +from typing import Dict, Iterator, List, Set, Tuple +from tqdm import tqdm # type: ignore + + +def get_dtype_length(dtype: Dict[str, str]) -> int: + """Calculate dtype record length in bytes. + + Arguments: + dtype {Dict[str, str]} -- column dtype Dict[column_name: column_dtype] + + Returns: + int -- length of record in bytes + """ + return sum(int(label.strip("><|SUuif")) for label in dtype.values()) + + +def iterate_lines(path: str) -> Iterator: + """Iterate lines of a file, even if gzipped.""" + if not path.endswith(".gz"): + yield from open(path) + else: + with gzip.open(path) as IH: + for line in IH: + yield line.decode() + + +def parse_hush(path: str) -> pd.DataFrame: + """Parse HUSH output. + + Arguments: + path {str} -- path to HUSH output file + + Returns: + pd.DataFrame -- parsed HUSH data + """ + if not os.path.isfile(path): + raise AssertionError(f"cannot find file '{path}'") + logging.info(f"parsing: '{path}'") + sequence_lengths: Set[int] = set() + parsed_lines: List[Tuple[str, str, int]] = [] + + header = "" + for line in tqdm(iterate_lines(path), desc="Parsing hush output", leave=False): + if line.startswith(">"): + header = line.strip() + else: + line_split = line.strip().split(",") + parsed_lines.append((header[1:], line_split[0], int(line_split[1].strip()))) + sequence_lengths.add(len(line_split[0])) + header = "" + + hush_df = pd.DataFrame(parsed_lines, columns=["name", "sequence", "off_target_no"]) + hush_df.set_index("name", inplace=True) + ass.ert_in_dtype(hush_df["off_target_no"].values.max(), "u4") + dtype = copy.copy(const.dtype_hush) + dtype["sequence"] = f"|S{max(sequence_lengths)}" + return hush_df.astype(dtype) + + +def parse_melting(path: str, sep: str = "\t", header: bool = True) -> pd.DataFrame: + """Parse oligo-melting output. + + Arguments: + path {str} -- path to oligo-melting output + + Keyword Arguments: + sep {str} -- column separator (default: {"t"}) + header {bool} -- whether to expect a header line (default: {True}) + + Returns: + pd.DataFrame -- parsed oligo-melting data + """ + if not os.path.isfile(path): + raise AssertionError(f"cannot find file '{path}'") + logging.info(f"parsing: '{path}'") + expected_columns = copy.copy(const.dtype_melting) + melting_df = pd.read_csv(path, sep=sep, header=None, skiprows=1 if header else 0) + if melting_df.shape[1] != len(expected_columns): + raise AssertionError + melting_df.columns = list(expected_columns.keys()) + melting_df.set_index("name", inplace=True) + expected_columns.pop("name", None) + expected_columns[ + "sequence" + ] = f'|S{max({len(seq) for seq in melting_df["sequence"].values})}' + return melting_df.astype(expected_columns) + + +def parse_secondary(path: str) -> pd.DataFrame: + """Parse OligoArrayAux .ct output. + + Arguments: + path {str} -- path to OligoArrayAux .ct output + + Returns: + pd.DataFrame -- parsed OligoArrayAux .ct data + """ + if not os.path.isfile(path): + raise AssertionError(f"cannot find file '{path}'") + logging.info(f"parsing: '{path}'") + parsed_lines: List[Tuple[str, float]] = [] + with open(path, "r") as IH: + for line in tqdm(IH, desc="Parsing OligoArrayAux output", leave=False): + if "dG = " not in line: + continue + _, dG_string, name = line.strip().split("\t") + parsed_lines.append((name, float(dG_string[5:]))) + secondary_df = pd.DataFrame(parsed_lines, columns=["name", "ss_dG"]) + secondary_df.set_index("name", inplace=True) + ass.ert_in_dtype(secondary_df["ss_dG"].values.max(), "f4") + return secondary_df.astype(const.dtype_secondary) + + +def write_oligos( + output_path: str, + oligo_generator: Iterator[Tuple[str, str]], + desc: str = "writing", +) -> None: + with open(output_path, "w+") as OH: + for oligo in tqdm(oligo_generator, desc=desc, leave=False): + OH.write(">%s\n%s\n" % oligo) diff --git a/ifpd2/logging.py b/ifpd2/logging.py index 6de9d49d..92047969 100644 --- a/ifpd2/logging.py +++ b/ifpd2/logging.py @@ -11,9 +11,11 @@ def add_log_file_handler(path: str, logger_name: Optional[str] = None) -> None: - assert not os.path.isdir(path) + if os.path.isdir(path): + raise AssertionError log_dir = os.path.dirname(path) - assert os.path.isdir(log_dir) or "" == log_dir + if not (os.path.isdir(log_dir) or log_dir == ""): + raise AssertionError fh = RichHandler(console=Console(file=open(path, mode="w+")), markup=True) fh.setLevel(logging.INFO) logging.getLogger(logger_name).addHandler(fh) diff --git a/ifpd2/oligo.py b/ifpd2/oligo.py index 2fcf8e2c..3f991c35 100644 --- a/ifpd2/oligo.py +++ b/ifpd2/oligo.py @@ -3,16 +3,19 @@ @contact: gigi.ga90@gmail.com """ +from ifpd2 import asserts as ass +from ifpd2.dataclasses import GCRange import logging import numpy as np # type: ignore import pandas as pd # type: ignore - -from ifpd2 import asserts as ass +from tqdm import tqdm # type: ignore +from typing import List, Tuple -class Oligo(object): +class Oligo: """Oligo database line/record parser. - Presents oligo values as properties.""" + Presents oligo values as properties. + """ _data = None @@ -35,7 +38,8 @@ class Oligo(object): def __init__(self, oligo, i): super(Oligo, self).__init__() ass.ert_type(i, int, "oligo id") - assert i >= 0 + if i < 0: + raise AssertionError self._raw_data = oligo.strip().split("\t") for i in [2, 3, 9, 10]: self._raw_data[i] = int(self._raw_data[i]) @@ -75,7 +79,7 @@ def score(self): @staticmethod def __norm_value_in_range(v, r): - if 0 == r[1]: + if r[1] == 0: return np.nan return (v - r[0]) / (r[1] - r[0]) @@ -83,10 +87,10 @@ def __update_score_by_nOT(self, F): nOT = self.data["nOT"].values if nOT <= F[0]: self.data["score"] = 0 - return + return None if nOT > F[1]: self.data["score"] = np.inf - return + return None return self.__norm_value_in_range(nOT, F) def __update_score_by_dG_Tm(self, Gs): @@ -94,27 +98,27 @@ def __update_score_by_dG_Tm(self, Gs): tm_dG = self.data["tm_dG"].values if ss_dG >= tm_dG * min(Gs): self.data["score"] = 0 - return + return None if ss_dG < tm_dG * max(Gs): self.data["score"] = np.inf - return + return None return self.__norm_value_in_range(ss_dG, [tm_dG * f for f in Gs]) def __update_score_by_dG_Gs(self, Gs): ss_dG = self.data["ss_dG"].values if ss_dG >= Gs[0]: self.data["score"] = 0 - return + return None if ss_dG < Gs[1]: self.data["score"] = np.inf - return + return None return self.__norm_value_in_range(ss_dG, Gs) def add_score(self, F, Gs): norm_nOT = self.__update_score_by_nOT(F) if norm_nOT is None: return - if all([x >= 0 for x in Gs]): + if all(x >= 0 for x in Gs): norm_ss_dG = self.__update_score_by_dG_Tm(Gs) else: norm_ss_dG = self.__update_score_by_dG_Gs(Gs) @@ -123,10 +127,11 @@ def add_score(self, F, Gs): self.data["score"] = np.mean([norm_nOT, norm_ss_dG]) -class OligoGroup(object): +class OligoGroup: """Allows to select oligos from a group based on a "focus" window of interest. The window can be expanded to the closest oligo or to retain at - least a given number of oligos.""" + least a given number of oligos. + """ _focus_window = None # Left-close, right-open _oligos_in_focus_window = None @@ -135,9 +140,12 @@ class OligoGroup(object): def __init__(self, oligos, logger=logging.getLogger()): super(OligoGroup, self).__init__() self.logger = logger - self._data = pd.concat([o.data for o in oligos], ignore_index=True) + self._data = pd.concat( + [o.to_dataframe() for o in oligos if np.isfinite(o["score"])], + ignore_index=True, + ) self._data = self._data.loc[self._data["score"] <= 1, :] - self._oligos_passing_score_filter = self._data["score"].values <= 1 + self._oligos_passing_score_filter = self._data.shape[0] @property def data(self): @@ -150,8 +158,10 @@ def focus_window(self): @focus_window.setter def focus_window(self, focus_window): ass.ert_type(focus_window, tuple, "focus window") - assert 2 == len(focus_window) - assert focus_window[1] > focus_window[0] + if len(focus_window) != 2: + raise AssertionError + if focus_window[1] <= focus_window[0]: + raise AssertionError self._focus_window = focus_window @property @@ -181,11 +191,10 @@ def usable_oligos(self): def get_focused_oligos(self, onlyUsable=False): if onlyUsable: return self._data.loc[self.usable_oligos] - else: - return self._data.loc[self.oligos_in_focus_window, :] + return self._data.loc[self.oligos_in_focus_window, :] def get_n_focused_oligos(self, onlyUsable=False): - if 0 == self.usable_oligos.sum(): + if self.usable_oligos.sum() == 0: return 0 return self.get_focused_oligos(onlyUsable).shape[0] @@ -217,12 +226,13 @@ def set_focus_window(self, start, end, verbose=True): def expand_focus_to_n_oligos(self, n, verbose=True): # Expand the sub-window of interest to retrieve at least n oligos - assert not isinstance(self.focus_window, type(None)) + if isinstance(self.focus_window, type(None)): + raise AssertionError if n <= self.get_n_focused_oligos(): return - for i in range(n - self.get_n_focused_oligos()): + for _ in range(n - self.get_n_focused_oligos()): if not self.expand_focus_to_closest(): return @@ -240,19 +250,22 @@ def expand_focus_to_n_oligos(self, n, verbose=True): def expand_focus_by_step(self, step, verbose=True): # Expand the current focus window of a given step (in nt) - assert 0 < step - - if self.focus_window[0] <= self._data["start"].min(): - if self.focus_window[1] >= self._data["end"].max(): - self.logger.warning( - " ".join( - [ - "Cannot expand the focus region any further ", - "(all oligos already included)", - ] - ) + if step >= 0: + raise AssertionError + + if ( + self.focus_window[0] <= self._data["start"].min() + and self.focus_window[1] >= self._data["end"].max() + ): + self.logger.warning( + " ".join( + [ + "Cannot expand the focus region any further ", + "(all oligos already included)", + ] ) - return False + ) + return False new_focus_start, new_focus_end = self.focus_window new_focus_start -= step / 2 @@ -266,18 +279,10 @@ def expand_focus_by_step(self, step, verbose=True): def __get_focus_extremes(self): earl = self._data["start"].values < self.focus_window[0] max_start = self._data.loc[earl, "start"].max() - if 0 != earl.sum(): - d_earl = self.focus_window[0] - max_start - else: - d_earl = np.inf - + d_earl = self.focus_window[0] - max_start if earl.sum() != 0 else np.inf late = self._data["end"].values >= self.focus_window[1] min_end = self._data.loc[late, "end"].min() - if 0 != late.sum(): - d_late = min_end - self.focus_window[1] - else: - d_late = np.inf - + d_late = min_end - self.focus_window[1] if late.sum() != 0 else np.inf return (max_start, min_end, d_earl, d_late) def __set_focus_windows_for_inifinite_extreme(self): @@ -319,7 +324,8 @@ def expand_focus_to_closest(self): def apply_threshold(self, threshold): # Unfocuses oligos with score higher than the threshold - assert threshold <= 1 and threshold >= 0 + if threshold > 1 or threshold < 0: + raise AssertionError self._oligos_passing_score_filter = self._data["score"] <= threshold def reset_threshold(self): @@ -337,32 +343,35 @@ def __check_oligos_to_discard_safeN(self, safeN, start, end, D): c = 1 while c <= safeN: passing_oData = oData.loc[oData["start"] > start, :] - if 0 == passing_oData.shape[0]: + if passing_oData.shape[0] == 0: self.logger.info("Not enough oligos, skipped discard step.") return False start = passing_oData["start"].values[0] - start += len(passing_oData["seq"].values[0]) + D + start += len(passing_oData["sequence"].values[0]) + D c += 1 c = 1 while c <= safeN: passing_oData = oData.loc[oData["end"] <= end] - if 0 == passing_oData.shape[-1]: + if passing_oData.shape[-1] == 0: self.logger.info("Not enough oligos, skipped discard step.") return False end = passing_oData["end"].values[-1] - end -= len(passing_oData["seq"].values[-1]) - D + end -= len(passing_oData["sequence"].values[-1]) - D c += 1 return True def discard_focused_oligos_safeN(self, safeN, D): # Discard focused oligos that are neither the first nor the last safeN - start = self.data.loc[self.oligos_in_focus_window, "start"].values[0] - start += len(self.data.loc[self.oligos_in_focus_window, "seq"].values[0]) + D + start += ( + len(self.data.loc[self.oligos_in_focus_window, "sequence"].values[0]) + D + ) end = self.data.loc[self.oligos_in_focus_window, "end"].values[-1] - end += len(self.data.loc[self.oligos_in_focus_window, "seq"].values[-1]) + D + end += ( + len(self.data.loc[self.oligos_in_focus_window, "sequence"].values[-1]) + D + ) if not self.__check_oligos_to_discard_safeN(safeN, start, end, D): return @@ -389,3 +398,16 @@ def __apply_keep_condition(self, keep_condition): self._oligos_passing_score_filter = self._oligos_passing_score_filter[ keep_condition ] + + +def select_by_GC( + oligos_list: List[Tuple[str, str]], + kmer_size: int, + gc_range: GCRange = GCRange(0.35, 0.85), +) -> List[Tuple[str, str]]: + return [ + (header, sequence) + for header, sequence in tqdm(oligos_list, desc="GC check", leave=False) + if (sequence.count("C") + sequence.count("G")) / kmer_size >= gc_range.low + and (sequence.count("C") + sequence.count("G")) / kmer_size <= gc_range.high + ] diff --git a/ifpd2/probe.py b/ifpd2/probe.py index 213402ec..d2a78723 100644 --- a/ifpd2/probe.py +++ b/ifpd2/probe.py @@ -12,7 +12,7 @@ from ifpd2 import asserts as ass -class OligoProbe(object): +class OligoProbe: """Converts a DataFrame of oligo data into an OligoProbe.""" def __init__(self, oligo_data): @@ -25,9 +25,11 @@ def data(self): @data.setter def data(self, oligo_data): - assert isinstance(oligo_data, pd.DataFrame) + if not isinstance(oligo_data, pd.DataFrame): + raise AssertionError required_columns = ["start", "end", "Tm"] - assert all([col in oligo_data.columns for col in required_columns]) + if any(col not in oligo_data.columns for col in required_columns): + raise AssertionError self._data = oligo_data self._range = (self._data["start"].min(), self._data["end"].max()) self._size = self._range[1] - self._range[0] @@ -108,7 +110,8 @@ def count_shared_oligos(self, probe): return np.intersect1d(self.path, probe.path).shape[0] def export(self, path): - assert not os.path.isfile(path) + if os.path.isfile(path): + raise AssertionError if os.path.isdir(path): shutil.rmtree(path) os.mkdir(path) @@ -123,27 +126,25 @@ def export(self, path): "".join( [ f">{oligo['name']}:", - f"{oligo['chrom']}:{oligo['start']}-{oligo['end']}\n", + f"{oligo['chromosome']}:{oligo['start']}-{oligo['end']}\n", ] ) ) - BH.write(f"{oligo['seq']}\n") + BH.write(f"{oligo['sequence']}\n") -class OligoPathBuilder(object): +class OligoPathBuilder: """OligoPathBuilder contains methods to select non-overlapping sets of - oligos (i.e., probes) from an oligo DataFrame in input.""" + oligos (i.e., probes) from an oligo DataFrame in input. + """ N = int(48) # Number of oligos per probe - D = int(2) # Minimum distance between consecutive oligos + D: int = int(2) # Minimum distance between consecutive oligos Tr = 10.0 # Melting temperature range half-width Ps = int(10000) # Probe size threshold, in nt (Ps > 1) Ph = 0.1 # Maximum hole size in probe as fraction of probe size Po = 0.5 # Probe oligo intersection threshold for path reduction - def __init__(self): - super(OligoPathBuilder, self).__init__() - def _assert(self): ass.ert_type(self.N, int, "N") ass.ert_nonNeg(self.N, "N") @@ -155,7 +156,8 @@ def _assert(self): ass.ert_nonNeg(self.Tr, "Tr") ass.ert_type(self.Ps, int, "Ps") - assert self.Ps > 1 + if self.Ps <= 1: + raise AssertionError ass.ert_type(self.Ph, float, "Ph") ass.ert_inInterv(self.Ph, 0, 1, "Ph") @@ -171,7 +173,7 @@ def get_paths(A): idxs = [ i for i in range(A.shape[0] - 1) - if i in path_start_set or 0 != len(A[i, i + 1].nonzero()[0]) + if i in path_start_set or len(A[i, i + 1].nonzero()[0]) != 0 ] for i in idxs: @@ -202,18 +204,16 @@ def get_non_overlapping_paths(oData, D): # distance equal to D ass.ert_type(oData, pd.DataFrame, "oData") - edges = [] start_positions = oData["start"].values end_positions = oData["end"].values - for i in range(oData.shape[0]): - edges.append( - np.logical_or( - end_positions + D < oData["start"].values[i], - start_positions - D >= oData["end"].values[i], - ) + edges = [ + np.logical_or( + end_positions + D < oData["start"].values[i], + start_positions - D >= oData["end"].values[i], ) - + for i in range(oData.shape[0]) + ] return OligoPathBuilder.get_paths(np.vstack(edges).astype("i")) def __size_paths(self, path_set, exit_polls): @@ -247,7 +247,7 @@ def filter_paths(self, path_set, oData): continue selected_paths.add(path) - comment = "".join([f"{r}{c}" for (c, r) in exit_polls.items()]) + comment = "".join(f"{r}{c}" for (c, r) in exit_polls.items()) return (list(selected_paths), comment) def __path_passes(self, path, oData): @@ -272,7 +272,7 @@ def convert_paths_to_probes(path_list, oData): # Converts a list of paths into a list of probes ass.ert_type(path_list, list, "path list") probe_list = [] - if 0 != len(path_list): + if len(path_list) != 0: for path in path_list: probe_list.append(OligoProbeBuilder.path2probe(path, oData)) return probe_list @@ -286,15 +286,14 @@ def path2probe(path, oData): class OligoProbeBuilder(OligoPathBuilder): """Class to build OligoProbe objects.""" - k = None - F = (0, 100) # Threshold on number of off-targets (range) - Gs = (0.0, 0.5) # dG of SS either as kcal/mol (negative) - # or as fraction dG of hybrid (0<=Gs<=1) - # (range) - Ot = 0.1 # Step for oligo score relaxation - def __init__(self): super(OligoProbeBuilder, self).__init__() + self.k = None + self.F = [0, 99] # Threshold on number of off-targets (range) + self.Gs = [0.0, 0.5] # dG of SS either as kcal/mol (negative) + # or as fraction dG of hybrid (0<=Gs<=1) + # (range) + self.Ot = 0.1 # Step for oligo score relaxation @property def config(self): @@ -321,38 +320,50 @@ def _assert(self): if not isinstance(self.k, type(None)): ass.ert_type(self.k, int, "k") ass.ert_nonNeg(self.k, "k") - assert (self.k + self.D) * self.N <= self.Ps - - ass.ert_type(self.F, tuple, "F") - assert 2 == len(self.F) + if (self.k + self.D) * self.N > self.Ps: + raise AssertionError + + if isinstance(self.F, tuple): + self.F = list(self.F) + ass.ert_type(self.F, list, "F") + if len(self.F) != 2: + raise AssertionError for i in range(2): ass.ert_type(self.F[i], int, f"F[{i}]") - assert self.F[i] >= 0 - assert self.F[1] >= self.F[0] - - ass.ert_type(self.Gs, tuple, "Gs") - assert 2 == len(self.Gs) + if self.F[i] < 0: + raise AssertionError + if self.F[1] < self.F[0]: + raise AssertionError + + if isinstance(self.Gs, tuple): + self.Gs = list(self.Gs) + ass.ert_type(self.Gs, list, "Gs") + if len(self.Gs) != 2: + raise AssertionError for i in range(2): ass.ert_type(self.Gs[i], float, f"Gs[{i}]") - assert self.Gs[i] <= 1 - assert all(np.array(self.Gs) < 0) or all(np.array(self.Gs) >= 0) + if self.Gs[i] > 1: + raise AssertionError + if not all(np.array(self.Gs) < 0) and not all(np.array(self.Gs) >= 0): + raise AssertionError if self.Gs[0] >= 0: - assert self.Gs[1] >= self.Gs[0] - else: - assert self.Gs[1] <= self.Gs[0] + if self.Gs[1] < self.Gs[0]: + raise AssertionError + elif self.Gs[1] > self.Gs[0]: + raise AssertionError ass.ert_type(self.Ot, float, "Ot") - assert 0 < self.Ot and 1 >= self.Ot + if self.Ot <= 0 or self.Ot > 1: + raise AssertionError def get_prologue(self): s = "* OligoProbeBuilder *\n\n" s += f"Aim to build probes with {self.N} oligos each.\n" s += f"Off-target threshold range set at {self.F}.\n" + s += "Threshold on the delta free energy of the most stable" if isinstance(self.Gs[0], int): - s += "Threshold on the delta free energy of the most stable" s += f" secondary structure set at range {self.Gs} kcal/mol.\n" else: - s += "Threshold on the delta free energy of the most stable" s += " secondary structure\nset at range" s += f" {[t*100 for t in self.Gs]}% of the delta free energy of" s += " hybridization.\n" @@ -384,7 +395,7 @@ def __build_probe_candidates(self, oGroup, window, cfr_step, logger): oGroup = self.__focus_oligos(window, oGroup) probe_list = self.__explore_filter(oGroup, logger) if not np.isnan(window["cfr_start"]): - while 0 == len(probe_list): + while len(probe_list) == 0: oGroup.reset_threshold() if oGroup.focus_window_size >= self.Ps: oGroup.discard_focused_oligos_safeN(self.N - 1, self.D) @@ -400,14 +411,14 @@ def __build_probe_list(self, oGroup, noligos, score_thr, max_score, logger): probe_list = self.__get_non_overlapping_probes( oGroup.get_focused_oligos(True), logger ) - while 0 == len(probe_list): + while len(probe_list) == 0: score_thr += self.Ot if score_thr > max_score: break oGroup.apply_threshold(score_thr) nOligosUsable = oGroup.get_n_focused_oligos(True) - if nOligosUsable == noligos or 0 == nOligosUsable: + if nOligosUsable in [noligos, 0]: continue logger.info( @@ -458,10 +469,10 @@ def __explore_filter(self, oGroup, logger): ) ) - if 0 == max_score and 0 == nOligos_prev_score_thr: + if max_score == 0 and nOligos_prev_score_thr == 0: return [] - while 0 == nOligos_prev_score_thr and score_thr <= max_score - self.Ot: + while nOligos_prev_score_thr == 0 and score_thr <= max_score - self.Ot: score_thr += self.Ot oGroup.apply_threshold(score_thr) nOligos_prev_score_thr = oGroup.get_n_focused_oligos(True) @@ -484,7 +495,7 @@ def __get_non_overlapping_probes(self, oData, logger, verbosity=True): # to OligoProbe objects. paths = self.get_non_overlapping_paths(oData, self.D) - if 0 == len(paths): + if len(paths) == 0: logger.warning("No oligo paths found.") return [] @@ -538,7 +549,7 @@ def __init_probe_selection(self, sorted_probes): def reduce_probe_list(self, probe_list): try: - if 0 == len(probe_list): + if len(probe_list) == 0: return [] sorted_probes = sorted(probe_list, key=lambda p: p.range[0]) @@ -553,25 +564,21 @@ def reduce_probe_list(self, probe_list): print(e) raise - def select_probe_from_pair(self, probeA, probeB): + @staticmethod + def select_probe_from_pair(probeA, probeB): if probeA.size < probeB.size: return probeA - else: - return probeB if np.diff(probeA.tm_range)[0] < np.diff(probeB.tm_range)[0]: return probeA - else: - return probeB if probeA.spread / probeA.d_mean < probeB.spread / probeB.d_mean: return probeA - else: - return probeB - return probeA + return probeB @staticmethod def import_probes(ipath): # Imports output from given directory path - assert os.path.isdir(ipath) + if not os.path.isdir(ipath): + raise AssertionError pPath = os.path.join(ipath, "probe_paths.tsv") if not os.path.isfile(pPath): @@ -584,16 +591,16 @@ def import_probes(ipath): oligos = pd.read_csv(oPath, "\t", index_col=0) paths = pd.read_csv(pPath, "\t", index_col=0) - probe_list = [] - for p in paths.iloc[:, 0]: - probe_list.append(OligoProbe(oligos.loc[[int(o) for o in p.split(",")]])) - - return probe_list + return [ + OligoProbe(oligos.loc[[int(o) for o in p.split(",")]]) + for p in paths.iloc[:, 0] + ] @staticmethod def export_probes(probe_list, opath): # Exports a list of probes to a directory - assert os.path.isdir(opath) + if not os.path.isdir(opath): + raise AssertionError probe_df = pd.concat([p.featDF for p in probe_list], ignore_index=True) probe_df.sort_values("start", inplace=True) @@ -603,11 +610,11 @@ def export_probes(probe_list, opath): os.path.join(opath, "oligos.tsv"), "\t" ) - probe_paths = [] - for pi in range(len(probe_list)): - probe_paths.append( - [",".join([str(x) for x in probe_list[pi].data.index.tolist()])] - ) + probe_paths = [ + [",".join(str(x) for x in probe_list[pi].data.index.tolist())] + for pi in range(len(probe_list)) + ] + probe_paths = pd.DataFrame(probe_paths) probe_paths.columns = ["cs_oligos"] probe_paths.to_csv(os.path.join(opath, "probe_paths.tsv"), "\t") diff --git a/ifpd2/probe_set.py b/ifpd2/probe_set.py index b5b70018..a519b24c 100644 --- a/ifpd2/probe_set.py +++ b/ifpd2/probe_set.py @@ -15,7 +15,7 @@ from ifpd2.probe import OligoProbe -class OligoProbeSet(object): +class OligoProbeSet: """Set of non-overlapping probes built from windows.""" def __init__(self, probe_list): @@ -28,7 +28,8 @@ def probe_list(self): @probe_list.setter def probe_list(self, probe_list): - assert all([isinstance(p, OligoProbe) for p in probe_list]) + if not all(isinstance(p, OligoProbe) for p in probe_list): + raise AssertionError self._probe_list = sorted(probe_list, key=lambda p: p.range[0]) self._probe_tm_ranges = [p.tm_range for p in self.probe_list] self._tm_range = ( @@ -41,10 +42,7 @@ def probe_list(self, probe_list): probe_starts = np.array([r[0] for r in self.probe_ranges]) probe_ends = np.array([r[1] for r in self.probe_ranges]) self._range = (probe_starts.min(), probe_ends.max()) - if 1 == len(probe_list): - self._ds = 0 - else: - self._ds = probe_starts[1:] - probe_ends[:-1] + self._ds = 0 if len(probe_list) == 1 else probe_starts[1:] - probe_ends[:-1] self._d_mean = np.mean(self.ds) self._d_range = (np.min(self.ds), np.max(self.ds)) tm = [p.data["Tm"].tolist() for p in self.probe_list] @@ -144,7 +142,8 @@ def featDF(self): return df def export(self, path): - assert not os.path.isfile(path) + if os.path.isfile(path): + raise AssertionError if os.path.isdir(path): shutil.rmtree(path) os.mkdir(path) @@ -165,31 +164,34 @@ def export(self, path): "".join( [ f">probe_{pi}:{oligo['name']}", - f":{oligo['chrom']}:{oligo['start']}-{oligo['end']}\n", + f":{oligo['chromosome']}:", + f"{oligo['start']}-{oligo['end']}\n", ] ) ) - BH.write(f"{probe.data.iloc[i]['seq']}\n") + BH.write(f"{probe.data.iloc[i]['sequence']}\n") -class OligoProbeSetBuilder(object): +class OligoProbeSetBuilder: """Class to build OligoProbeSet objects.""" probe_set_list: List = [] def __init__(self, out_path): super(OligoProbeSetBuilder, self).__init__() - assert not os.path.isfile(out_path) + if os.path.isfile(out_path): + raise AssertionError self.out_path = out_path if os.path.isdir(out_path): shutil.rmtree(out_path) os.mkdir(out_path) - def __build_probe_set_list(self, window_list, i): + @staticmethod + def __build_probe_set_list(window_list, i): probe_set_list = [(p,) for p in window_list[i]] for w in window_list[(i + 1) :]: - if 0 == len(w): + if len(w) == 0: continue current_probe_set_list = list(tuple(probe_set_list)) @@ -206,9 +208,15 @@ def __build_probe_set_list(self, window_list, i): def build(self, probe_candidates): for (wSet, window_list) in probe_candidates.items(): window_list = list(window_list.values()) - i = 0 - while 0 == len(window_list[i]): - i += 1 + + non_empty_ids = [ + i for i in range(len(window_list)) if len(window_list[i]) != 0 + ] + + if not non_empty_ids: + logging.warning(f"No probe candidates found, dropped. [ws{wSet+1}]") + continue + i = non_empty_ids[0] probe_set_list = self.__build_probe_set_list(window_list, i) @@ -227,7 +235,7 @@ def build(self, probe_candidates): f"Built {len(self.probe_set_list)} " + "probe set candidates in total." ) - if 0 < len(self.probe_set_list): + if self.probe_set_list: pd.concat([ps.featDF for ps in self.probe_set_list]).reset_index( drop=True ).to_csv(os.path.join(self.out_path, "probe_sets.tsv"), "\t") diff --git a/ifpd2/region.py b/ifpd2/region.py new file mode 100644 index 00000000..d437248a --- /dev/null +++ b/ifpd2/region.py @@ -0,0 +1,259 @@ +""" +@author: Gabriele Girelli +@contact: gigi.ga90@gmail.com +""" + +from ifpd2.chromosome import ChromosomeData +import logging +from typing import List, Tuple + + +class GenomicRegion: + """Details on genomic region with a central focus region.""" + + __chrom: bytes + __chromStart: int + __chromEnd: int + __focusStart: int + __focusEnd: int + __focusSize: int + __focusStep: int + + def __init__( + self, + chrom_region: Tuple[bytes, int, int], + focus_style: Tuple[float, float] = (1, 1), + ): + super(GenomicRegion, self).__init__() + self.__init_region(*chrom_region) + self.__init_focus(*focus_style) + + def __init_region(self, chrom: bytes, chromStart: int, chromEnd: int) -> None: + """Initialize region coordinates. + + Arguments: + chrom {bytes} -- chromosome name + chromStart {int} -- chromosome start position (usually 0) + chromEnd {int} -- chromosome end position + """ + if len(chrom) == 0: + raise AssertionError("chromosome cannot be empty") + if chromStart < 0: + raise AssertionError( + f"start should be greater than or equal to 0: {chromStart}" + ) + if chromEnd <= chromStart: + raise AssertionError( + f"end should be greater than start: {chromStart}-{chromEnd}" + ) + self.__chrom = chrom + self.__chromStart = chromStart + self.__chromEnd = chromEnd + + def __init_focus_size(self, focus_style: float) -> None: + """Initialize focus region size. + + Set the size of the central focus region. When focus style is lower than or + equal to 1, it is considered to be a fraction of the genomic region size. When + it is greater than 1, instead, it is considered to be the size in nt. + + Arguments: + focus_style {float} -- focus region size in nt + or as a fraction of the genomic region + """ + if focus_style <= 0: + raise AssertionError + if focus_style > 1: + if focus_style > self.__chromEnd - self.__chromStart: + raise AssertionError + self.__focusSize = int(focus_style) + else: + self.__focusSize = int((self.__chromEnd - self.__chromStart) * focus_style) + + def __init_focus_step(self, step_style: float) -> None: + """Initialize step for focus region growth. + + Set the step at which the focus region grows. When step style is lower than or + equal to 1, it is considered to be a fraction of the focus region size. When + it is greater than 1, instead, it is considered to be in nt. + + Arguments: + step_style {float} -- focus region growth step in nt + or as a fraction of the focus region + """ + if step_style <= 0: + raise AssertionError + if step_style > 1: + self.__focusStep = int(step_style) + else: + self.__focusStep = int(self.__focusSize * step_style) + + def __init_focus(self, focus_style: float, focus_step_style: float) -> None: + """Initialize focus region. + + More details on focus and focus step style in the __init_focus_size and + __init_focus_step functions. + + Arguments: + focus_style {float} -- focus region size in nt + or as a fraction of the genomic region + focus_step_style {float} -- focus region growth step in nt + or as a fraction of the focus region + """ + self.__init_focus_size(focus_style) + self.__init_focus_step(focus_step_style) + self.__focusStart = int( + (self.__chromStart + self.__chromEnd) / 2 - self.__focusSize / 2 + ) + self.__focusEnd = int( + (self.__chromStart + self.__chromEnd) / 2 + self.__focusSize / 2 + ) + + @property + def chromosome(self) -> bytes: + return self.__chrom + + @property + def start(self) -> int: + return self.__chromStart + + @property + def end(self) -> int: + return self.__chromEnd + + @property + def region(self) -> Tuple[int, int]: + return (self.__chromStart, self.__chromEnd) + + @property + def focus(self) -> Tuple[int, int]: + return (self.__focusStart, self.__focusEnd) + + # @property + # def focus_step(self) -> int: + # return self.__focusStep + + def can_increase_focus(self) -> bool: + """Check if the focus region can grow more + + Returns: + bool -- whether growth is possible + """ + return self.focus != self.region + + def increase_focus(self) -> None: + """Grow the focus region.""" + if self.can_increase_focus(): + logging.warning("cannot increase the focus region any further") + self.__focusStart = max( + self.__chromStart, self.__focusStart - self.__focusStep // 2 + ) + self.__focusEnd = min(self.__chromEnd, self.__focusEnd + self.__focusStep // 2) + + +class GenomicRegionBuilder: + """docstring for GenomicRegionBuilder""" + + __chromosome: bytes + __chromosome_size_nt: int + __focus_style: Tuple[float, float] + + def __init__( + self, + chromosome_data: ChromosomeData, + focus_style: float = 1, + focus_step_style: float = 1, + ): + super(GenomicRegionBuilder, self).__init__() + self.__chromosome = chromosome_data.name + self.__chromosome_size_nt = chromosome_data.size_nt + if focus_style <= 0: + raise AssertionError + if focus_step_style <= 0: + raise AssertionError + self.__focus_style = (focus_style, focus_step_style) + + def __build_overlapping(self, size: int, step: int) -> List[List[GenomicRegion]]: + """Build lists of regions. + + Windows are generated based on size and step. Step should be smaller than size. + Overlapping regions are placed in separate lists. + + Arguments: + size {int} -- region size in nt + step {int} -- region step in nt + + Returns: + List[List[GenomicRegion]] -- generated region lists + """ + if step >= size: + raise AssertionError + region_set_list: List[List[GenomicRegion]] = [] + for range_start in range(0, size, step): + genomic_region_set: List[GenomicRegion] = [] + for start in range(range_start, self.__chromosome_size_nt, step): + end = start + size + if end < self.__chromosome_size_nt: + genomic_region_set.append( + GenomicRegion( + (self.__chromosome, start, end), self.__focus_style + ) + ) + region_set_list.append(genomic_region_set) + return region_set_list + + def __build_non_overlapping( + self, size: int, step: int + ) -> List[List[GenomicRegion]]: + """Build a list of non-overlapping regions. + + Arguments: + size {int} -- region size in nt + step {int} -- region step in nt + + Returns: + List[List[GenomicRegion]] -- generated region lists + """ + if step != size: + raise AssertionError + genomic_region_set: List[GenomicRegion] = [] + for start in range(0, self.__chromosome_size_nt, step): + end = start + size + if end <= self.__chromosome_size_nt: + genomic_region_set.append( + GenomicRegion((self.__chromosome, start, end), self.__focus_style) + ) + return [genomic_region_set] + + def build_by_number(self, n: int) -> List[List[GenomicRegion]]: + """Build a number of regions. + + Build a number of region instances covering the current chromosome. + + Arguments: + n {int} -- number of regions + + Returns: + List[List[GenomicRegion]] -- generated region lists + """ + step: int = self.__chromosome_size_nt // n + return self.build_by_size(step, step) + + def build_by_size(self, size: int, step_style: float) -> List[List[GenomicRegion]]: + """Build regions by size and step (allows for overlap). + + Build region instances based on their size and step. Step is the distance + between the start of a region and the start of the next region. Overlapping + regions are placed in separate lists. + + Arguments: + size {int} -- region size in nt + step_style {float} -- region step in nt or as a fraction of the region size + + Returns: + List[List[GenomicRegion]] -- generated region lists + """ + step = int(step_style) if step_style > 1 else int(size * step_style) + if step < size: + return self.__build_overlapping(size, step) + return self.__build_non_overlapping(size, step) diff --git a/ifpd2/scripts/__init__.py b/ifpd2/scripts/__init__.py index fe93908b..0a89b35e 100644 --- a/ifpd2/scripts/__init__.py +++ b/ifpd2/scripts/__init__.py @@ -3,9 +3,9 @@ @contact: gigi.ga90@gmail.com """ -from ifpd2.scripts import arguments, ifpd2 -from ifpd2.scripts import dbchk -from ifpd2.scripts import query +from ifpd2.scripts import autocomplete, ifpd2 +from ifpd2.scripts import db, extract_kmers +from ifpd2.scripts import query, query2 import logging from rich.logging import RichHandler # type: ignore @@ -16,4 +16,11 @@ handlers=[RichHandler(markup=True, rich_tracebacks=True)], ) -__all__ = ["arguments", "ifpd2", "dbchk", "query"] +__all__ = [ + "autocomplete", + "ifpd2", + "db", + "extract_kmers", + "query", + "query2", +] diff --git a/ifpd2/scripts/arguments.py b/ifpd2/scripts/arguments.py index 6181b803..ce65f497 100644 --- a/ifpd2/scripts/arguments.py +++ b/ifpd2/scripts/arguments.py @@ -4,21 +4,14 @@ """ import argparse -from ifpd2.const import __version__ -import multiprocessing as mp +from ifpd2 import __version__ import sys +# import multiprocessing as mp + def add_version_option(parser: argparse.ArgumentParser) -> argparse.ArgumentParser: parser.add_argument( "--version", action="version", version=f"{sys.argv[0]} {__version__}" ) return parser - - -def check_threads(threads: int) -> int: - if threads > mp.cpu_count(): - return mp.cpu_count() - elif threads <= 0: - return 1 - return threads diff --git a/ifpd2/scripts/autocomplete.py b/ifpd2/scripts/autocomplete.py new file mode 100644 index 00000000..6f6b5a1b --- /dev/null +++ b/ifpd2/scripts/autocomplete.py @@ -0,0 +1,92 @@ +""" +@author: Gabriele Girelli +@contact: gigi.ga90@gmail.com +""" + +import click # type: ignore +import os +from rich import print # type: ignore +import shlex +from shutil import copyfile +import sys + +from ifpd2 import __path__, __version__ +from ifpd2.const import CONTEXT_SETTINGS + + +SHELL_TYPES = ("bash", "zsh", "fish") + + +@click.command(context_settings=CONTEXT_SETTINGS) +@click.option( + "--shell-type", + "-s", + help="shell type for which to activate autocompletion", + type=click.Choice(SHELL_TYPES, case_sensitive=False), + default="bash", + show_default=True, +) +@click.option( + "--regenerate", + help="to regenerate autocompletion file, mainly for developers", + type=click.BOOL, + default=False, + is_flag=True, +) +@click.version_option(__version__) +def main(shell_type: str, regenerate: bool) -> None: + user_home_path = os.path.expanduser("~") + autocomplete_path = os.path.join( + __path__[0], "autocomplete", f".ifpd2-complete.{shell_type}" + ) + + if regenerate: + regenerate_autocompletion_files(shell_type, autocomplete_path) + + if shell_type in {"bash", "zsh"}: + autocomplete_bash_or_zsh(user_home_path, autocomplete_path, shell_type) + elif shell_type == "fish": + autocomplete_fish(user_home_path, autocomplete_path) + + print("Done. :thumbs_up: :smiley:") + + +def regenerate_autocompletion_files(shell_type: str, autocomplete_path: str) -> None: + if shell_type not in SHELL_TYPES: + raise AssertionError(f"unrecognized shell type '{shell_type}'.") + cmd = f"_IFPD2_COMPLETE={shell_type}_source ifpd2 > {autocomplete_path}" + os.system(shlex.quote(cmd)) + print(f"Regenerated {shell_type} completion file: {autocomplete_path}") + + +def autocomplete_fish(user_home_path: str, autocomplete_path: str) -> None: + destination_path = os.path.join( + user_home_path, ".config/fish/completions/ifpd2.fish" + ) + + if os.path.isfile(destination_path): + print("Autocompletion was previously set up. Skipping.") + sys.exit() + + copyfile( + autocomplete_path, + destination_path, + ) + + +def autocomplete_bash_or_zsh( + user_home_path: str, autocomplete_path: str, shell_type: str = "bash" +) -> None: + if shell_type not in {"bash", "zsh"}: + raise AssertionError + + autocompletion_string = f". {autocomplete_path} # IFPD2-AUTOCOMPLETE\n" + run_command_path = os.path.join(user_home_path, f".{shell_type}rc") + + with open(run_command_path, "r") as OH: + if autocompletion_string in OH.readlines(): + print("Autocompletion was previously set up. Skipping.") + sys.exit() + + with open(run_command_path, "a+") as OH: + OH.write(f"\n{autocompletion_string}") diff --git a/ifpd2/scripts/db/__init__.py b/ifpd2/scripts/db/__init__.py new file mode 100644 index 00000000..61542aff --- /dev/null +++ b/ifpd2/scripts/db/__init__.py @@ -0,0 +1,9 @@ +""" +@author: Gabriele Girelli +@contact: gigi.ga90@gmail.com +""" + +from ifpd2.scripts.db import check, dump, info, make +from ifpd2.scripts.db import run, settings + +__all__ = ["check", "dump", "info", "make", "run", "settings"] diff --git a/ifpd2/scripts/db/check.py b/ifpd2/scripts/db/check.py new file mode 100644 index 00000000..eb6c99b7 --- /dev/null +++ b/ifpd2/scripts/db/check.py @@ -0,0 +1,33 @@ +""" +@author: Gabriele Girelli +@contact: gigi.ga90@gmail.com +""" + +import click # type: ignore +from ifpd2.const import CONTEXT_SETTINGS +from ifpd2.database import DataBase +from ifpd2.walker2 import ChromosomeWalker +import logging +from tqdm import tqdm # type: ignore + + +@click.command( + name="check", + context_settings=CONTEXT_SETTINGS, + help="""Check integrity of INPUT database.""", +) +@click.argument("input_paths", metavar="INPUT", nargs=1, type=click.Path(exists=True)) +def main(input_paths: str) -> None: + DB = DataBase(input_paths) + for chromosome in DB.chromosome_list: + walker = ChromosomeWalker(DB, chromosome) + previous_position = -1 + for record in tqdm( + walker.buffer(), + desc=f"Checking sorting '{chromosome.decode()}'", + total=DB.chromosome_recordnos[chromosome], + ): + if record["start"] <= previous_position: + raise AssertionError + previous_position = record["start"] + logging.info("That's all! :smiley:") diff --git a/ifpd2/scripts/db/dump.py b/ifpd2/scripts/db/dump.py new file mode 100644 index 00000000..211a0483 --- /dev/null +++ b/ifpd2/scripts/db/dump.py @@ -0,0 +1,78 @@ +""" +@author: Gabriele Girelli +@contact: gigi.ga90@gmail.com +""" + +import click # type: ignore +from ifpd2 import const +from ifpd2.database import DataBase +from ifpd2.walker2 import ChromosomeWalker +from tqdm import tqdm # type: ignore +from typing import List, Optional, Tuple + + +@click.command( + name="dump", + context_settings=const.CONTEXT_SETTINGS, + help="""Dump whole INPUT database to the terminal, in tsv format. + To dump a single feature, specify it with the --chrom option. + To dump a region of a feature, also use the --start and --end options.""", +) +@click.argument("input_paths", metavar="INPUT", nargs=1, type=click.Path(exists=True)) +@click.option("--chrom", type=click.STRING, help="Database chromosome to dump from.") +@click.option("--start", type=click.INT, help="Start location of the region to dump.") +@click.option("--end", type=click.INT, help="End location of the region to dump.") +def main( + input_paths: str, + chrom: Optional[str] = None, + start: Optional[int] = None, + end: Optional[int] = None, +) -> None: + DB = DataBase(input_paths) + chrom, start, end = check_region(DB, chrom, start, end) + + print("\t".join(const.database_columns)) + for chromosome in get_chromosome_list(DB, chrom): + walker = ChromosomeWalker(DB, chromosome) + for record in tqdm( + walker.buffer(start, end), + desc=f"dumping '{chromosome.decode()}'", + total=DB.chromosome_recordnos[chromosome], + ): + if start > record["start"]: + continue + print(record.to_csv("\t")) + + +def check_region( + DB: DataBase, + chrom: Optional[str] = None, + start: Optional[int] = None, + end: Optional[int] = None, +) -> Tuple[Optional[str], int, int]: + if chrom is None: + if start is not None or end is not None: + raise AssertionError( + "cannot use --region-start or --region-end without --chrom" + ) + elif start is not None: + chrom_size = DB.chromosome_sizes_nt[chrom.encode()] + if start >= chrom_size: + raise AssertionError(f"{start} larger than chromosome size: {chrom_size}") + if end is not None and start >= end: + raise AssertionError("end location smaller than start") + + return ( + chrom, + 0 if start is None else start, + -1 if end is None else end, + ) + + +def get_chromosome_list(DB: DataBase, chrom: Optional[str]) -> List[bytes]: + chromosome_list = DB.chromosome_list + if chrom is not None: + if chrom.encode() not in chromosome_list: + raise AssertionError(f"'{chrom}' not found") + chromosome_list = [chrom.encode()] + return chromosome_list diff --git a/ifpd2/scripts/db/info.py b/ifpd2/scripts/db/info.py new file mode 100644 index 00000000..f57b916d --- /dev/null +++ b/ifpd2/scripts/db/info.py @@ -0,0 +1,20 @@ +""" +@author: Gabriele Girelli +@contact: gigi.ga90@gmail.com +""" + +import click # type: ignore +from ifpd2.const import CONTEXT_SETTINGS +from ifpd2.database import DataBase +import logging + + +@click.command( + name="info", context_settings=CONTEXT_SETTINGS, help="Show INPUT database details." +) +@click.argument("input_paths", metavar="INPUT", nargs=1, type=click.Path(exists=True)) +def main(input_paths: str) -> None: + DB = DataBase(input_paths) + DB.log_details() + logging.info("") + logging.info("That's all! :smiley:") diff --git a/ifpd2/scripts/db/make.py b/ifpd2/scripts/db/make.py new file mode 100644 index 00000000..db0fadd7 --- /dev/null +++ b/ifpd2/scripts/db/make.py @@ -0,0 +1,283 @@ +""" +@author: Gabriele Girelli +@contact: gigi.ga90@gmail.com +""" + +import click # type: ignore +import copy +from ifpd2.const import CONTEXT_SETTINGS, DEFAULT_DATABASE_INDEX_BIN_SIZE +from ifpd2.const import dtype_header_features, dtype_sequence_features +from ifpd2.const import database_columns, dtype_hush, dtype_melting, dtype_secondary +from ifpd2 import asserts as ass +from ifpd2.chromosome import ChromosomeDict +from ifpd2.io import parse_hush, parse_melting, parse_secondary +from ifpd2.scripts.db.settings import DBMakeSettings +import logging +import numpy as np # type: ignore +import os +import pandas as pd # type: ignore +import pickle +from rich.progress import Progress, track # type: ignore +from typing import Callable, Dict, List, Set, Tuple + + +@click.command( + name="make", + context_settings=CONTEXT_SETTINGS, + help=""" +Assembles files into a database. At least one of the following is required, +to retrieve sequence: hush output (-O), or oligo-melting output (-T). + +The name of each record should be in the format: 'name pos=chrom:start-end'. + +Accepted formats: +hush single-line sequence fasta file, where a ", XXX" is appended after the + sequence. XXX is the number of detected off-targets. +oligo-melting .tsv file with six (6) columns: name, dG, dH, dS, Tm, Seq. + NOTE: the first line of the file is skipped during parsing because + it is expected to be a header line. +OligoArrayAux .ct (Connectivity Table) file. Details on format available here: + https://rna.urmc.rochester.edu/Text/File_Formats.html + +Files are merged by: hush header, oligo-melting name, and +OligoArrayAux name (3rd field of 1st column). +""", +) +@click.argument("output", nargs=1, type=click.Path(exists=False)) +@click.option( + "--hush", + "-O", + metavar="hush_path", + nargs=1, + multiple=True, + type=click.Path(exists=True), + help="Path to hush output. Format details above.", +) +@click.option( + "--melting", + "-T", + metavar="hush_oligomelting_pathpath", + nargs=1, + multiple=True, + type=click.Path(exists=True), + help="Path to oligo-melting output. Format details above.", +) +@click.option( + "--secondary", + "-S", + metavar="oligoarrayaux_path", + nargs=1, + multiple=True, + type=click.Path(exists=True), + help="Path to OligoArrayAux output. Format details above.", +) +@click.option( + "--prefix", + "-p", + type=click.STRING, + default="", + help="Prefix to be added to chromosome labels.", +) +@click.option( + "--binsize", + "-b", + default=DEFAULT_DATABASE_INDEX_BIN_SIZE, + type=click.INT, + help=f"Index bin size. Default: {DEFAULT_DATABASE_INDEX_BIN_SIZE}", +) +def main( + output: str, + hush: List[str], + melting: List[str], + secondary: List[str], + prefix: str, + binsize: int, +) -> None: + settings = DBMakeSettings(output) + settings.add_off_target_path_list(hush) + settings.add_melting_temperature_path_list(melting) + settings.add_secondary_structure_path_list(secondary) + settings.bin_size = binsize + settings.prefix = prefix + + if ( + len(settings.off_target_paths) == 0 + and len(settings.melting_temperature_paths) != 0 + ): + raise AssertionError("please provide either --hush or --melting") + + os.mkdir(settings.output_path) + dbdf = pd.DataFrame(columns=["name"]) + dbdf.set_index("name", inplace=True) + + dbdf = populate_db(dbdf, settings.off_target_paths, parse_hush, "hush") + dbdf = populate_db( + dbdf, settings.melting_temperature_paths, parse_melting, "oligo-melting" + ) + dbdf = populate_db( + dbdf, settings.secondary_structure_paths, parse_secondary, "OligoArrayAux" + ) + + dbdf = reduce_sequence_columns(dbdf) + dbdf, dtype_sequence = parse_sequences(dbdf) + dbdf, dtype_header = parse_record_headers(dbdf, prefix) + + dtype = {} + dtype.update(dtype_melting) + dtype.update(dtype_hush) + dtype.update(dtype_secondary) + dtype.update(dtype_sequence) + dtype.update(dtype_header) + + for column in dtype: + if column not in dbdf.columns: + dbdf["column"] = np.repeat(np.nan, dbdf.shape[0]) + dbdf = dbdf.loc[:, database_columns] + + write_database(dbdf, dtype, settings) + + logging.info("Done. :thumbs_up: :smiley:") + + +def parse_input( + path_list: Set[str], parse_function: Callable, software_name: str +) -> pd.DataFrame: + if not path_list: + return pd.DataFrame() + logging.info(f"parsing {software_name} output") + return pd.concat([parse_function(path) for path in path_list]) + + +def populate_db( + db: pd.DataFrame, + path_list: Set[str], + parse_function: Callable, + software_name: str, +) -> pd.DataFrame: + if not path_list: + return db + parsed_db = parse_input(path_list, parse_function, software_name) + logging.info(f"adding {software_name} output to database") + return db.merge( + parsed_db, + how="outer", + left_index=True, + right_index=True, + ) + + +def reduce_sequence_columns(df: pd.DataFrame) -> pd.DataFrame: + logging.info("discarding redundant sequence columns") + seq_columns = [c for c in df.columns if "sequence" in c] + if len(seq_columns) == 1: + return df + df.drop(seq_columns[1:], axis=1, inplace=True) + df.rename(columns={seq_columns[0]: "sequence"}, inplace=True) + return df + + +def parse_sequences(df: pd.DataFrame) -> Tuple[pd.DataFrame, Dict[str, str]]: + logging.info("adding sequence feature columns: length and GC-content") + sequence_length_list: List[int] = [] + gc_content_list: List[float] = [] + + for sequence in track( + df["sequence"].values, description="calculating GC-content", transient=True + ): + sequence = sequence.upper() + sequence_length_list.append(len(sequence)) + gc_content_list.append( + (sequence.count(b"G") + sequence.count(b"C")) / len(sequence) + ) + + df["gc_content"] = gc_content_list + dtype = copy.copy(dtype_sequence_features) + dtype["sequence"] = f"|S{max(sequence_length_list)}" + return (df.astype(dtype), dtype) + + +def parse_record_headers( + db: pd.DataFrame, chromosome_prefix: str = "" +) -> Tuple[pd.DataFrame, Dict[str, str]]: + logging.info("adding header feature columns: name, chromosome, start, end") + name_list: List[str] = [] + name_length_set: Set[int] = set() + chromosome_list: List[str] = [] + chromosome_length_set: Set[int] = set() + start_list: List[int] = [] + end_list: List[int] = [] + + for record in track( + db.itertuples(), + total=db.shape[0], + description="parsing record headers", + transient=True, + ): + name, position = record.Index.split(" ") + name_list.append(name) + name_length_set.add(len(name)) + chromosome, extremes = position.split("=")[1].split(":") + chromosome_list.append(f"{chromosome_prefix}{chromosome}") + chromosome_length_set.add(len(f"{chromosome_prefix}{chromosome}")) + start, end = [int(x) for x in extremes.split("-")] + if (end - start) != len(record.sequence): + raise AssertionError(f"{end - start} != {len(record.sequence)}") + start_list.append(start) + end_list.append(end) + + db["name"] = name_list + db["chromosome"] = chromosome_list + db["start"] = start_list + db["end"] = end_list + ass.ert_in_dtype(db["start"].values.max(), "u4") + ass.ert_in_dtype(db["end"].values.max(), "u4") + db.reset_index(drop=True, inplace=True) + + dtype = copy.copy(dtype_header_features) + dtype["name"] = f"|S{max(name_length_set)}" + dtype["chromosome"] = f"|S{max(chromosome_length_set)}" + return (db.astype(dtype), dtype) + + +def write_database( + dbdf: pd.DataFrame, dtype: Dict[str, str], settings: DBMakeSettings +) -> None: + with Progress() as progress: + chromosome_set: Set[bytes] = set(dbdf["chromosome"].values) + chromosome_data = ChromosomeDict(settings.bin_size) + chromosome_task = progress.add_task( + "exporting chromosome", + total=len(chromosome_set), + transient=True, + ) + for selected_chrom in chromosome_set: + chromosome_db = dbdf.loc[selected_chrom == dbdf["chromosome"], :] + + logging.info(f"sorting records for {selected_chrom.decode()}") + chromosome_db.sort_values( + by="start", axis=0, kind="mergesort", inplace=True + ) + logging.info(f"building index for {selected_chrom.decode()}") + chromosome_data.add_chromosome(chromosome_db, dtype, progress) + + with open( + os.path.join(settings.output_path, f"{selected_chrom.decode()}.bin"), + "wb", + ) as IH: + writing_track = progress.add_task( + f"writing {selected_chrom.decode()}.bin", + total=chromosome_db.shape[0], + transient=True, + ) + for record in chromosome_db.to_records( + index=False, column_dtypes=dtype + ): + IH.write(record.tobytes()) + progress.update(writing_track, advance=1) + progress.update(chromosome_task, advance=1) + + logging.info("writing db.pickle") + with open(os.path.join(settings.output_path, "db.pickle"), "wb") as OH: + pickle.dump( + dict(chromosomes=chromosome_data, dtype=dtype, args=settings.asdict()), OH + ) diff --git a/ifpd2/scripts/db/run.py b/ifpd2/scripts/db/run.py new file mode 100644 index 00000000..83fb68bd --- /dev/null +++ b/ifpd2/scripts/db/run.py @@ -0,0 +1,23 @@ +""" +@author: Gabriele Girelli +@contact: gigi.ga90@gmail.com +""" + +import click # type: ignore +from ifpd2.const import CONTEXT_SETTINGS +from ifpd2.scripts.db import check, dump, info, make + + +@click.group( + name="db", + context_settings=CONTEXT_SETTINGS, + help="Tools to manage ifpd2 databases.", +) +def main() -> None: + """Just a hook for the entry point. Silence is golden!""" + + +main.add_command(check.main) +main.add_command(dump.main) +main.add_command(info.main) +main.add_command(make.main) diff --git a/ifpd2/scripts/db/settings.py b/ifpd2/scripts/db/settings.py new file mode 100644 index 00000000..d383edce --- /dev/null +++ b/ifpd2/scripts/db/settings.py @@ -0,0 +1,102 @@ +""" +@author: Gabriele Girelli +@contact: gigi.ga90@gmail.com +""" + +from copy import copy +from ifpd2.const import DEFAULT_DATABASE_INDEX_BIN_SIZE +import logging +from os.path import isdir, isfile +from typing import Any, Dict, List, Set + + +class DBMakeSettings: + _output_path: str + _off_target_paths: Set[str] + _melting_temperature_paths: Set[str] + _secondary_structure_paths: Set[str] + _bin_size: int = DEFAULT_DATABASE_INDEX_BIN_SIZE + prefix: str = "" + + def __init__(self, output_path: str): + super(DBMakeSettings, self).__init__() + self.output_path = output_path + self._off_target_paths = set() + self._melting_temperature_paths = set() + self._secondary_structure_paths = set() + + @property + def output_path(self) -> str: + return self._output_path + + @output_path.setter + def output_path(self, output_path: str) -> None: + if isdir(output_path) or isfile(output_path): + raise AssertionError(f"'{output_path}' already exists") + self._output_path = output_path + + @property + def bin_size(self) -> int: + return self._bin_size + + @bin_size.setter + def bin_size(self, bin_size: int) -> None: + if bin_size < 1: + raise AssertionError + self._bin_size = bin_size + + @property + def off_target_paths(self) -> Set[str]: + return copy(self._off_target_paths) + + @property + def melting_temperature_paths(self) -> Set[str]: + return copy(self._melting_temperature_paths) + + @property + def secondary_structure_paths(self) -> Set[str]: + return copy(self._secondary_structure_paths) + + def add_off_target_path(self, path: str) -> None: + if not isfile(path): + raise AssertionError(f"'{path}' not found.") + self._off_target_paths.add(path) + + def add_off_target_path_list(self, path_list: List[str]) -> None: + for path in path_list: + self.add_off_target_path(path) + + def add_melting_temperature_path(self, path: str) -> None: + if not isfile(path): + raise AssertionError(f"'{path}' not found.") + self._melting_temperature_paths.add(path) + + def add_melting_temperature_path_list(self, path_list: List[str]) -> None: + for path in path_list: + self.add_melting_temperature_path(path) + + def add_secondary_structure_path(self, path: str) -> None: + if not isfile(path): + raise AssertionError(f"'{path}' not found.") + self._secondary_structure_paths.add(path) + + def add_secondary_structure_path_list(self, path_list: List[str]) -> None: + for path in path_list: + self.add_secondary_structure_path(path) + + def init_login(self) -> None: + logging.info(f"output folder: '{self.output_path}'") + logging.info(f"chromosome prefix: '{self.prefix}'") + logging.info(f"hush: {self.off_target_paths}") + logging.info(f"oligo-melting: {self.melting_temperature_paths}") + logging.info(f"OligoArrayAux: {self.secondary_structure_paths}") + + def asdict(self) -> Dict[str, Any]: + return dict( + output_path=self.output_path, + off_target_paths=self.off_target_paths, + melting_temperature_paths=self.melting_temperature_paths, + secondary_structure_paths=self.secondary_structure_paths, + bin_size=self.bin_size, + prefix=self.prefix, + ) diff --git a/ifpd2/scripts/dbchk.py b/ifpd2/scripts/dbchk.py deleted file mode 100644 index 79785b21..00000000 --- a/ifpd2/scripts/dbchk.py +++ /dev/null @@ -1,41 +0,0 @@ -""" -@author: Gabriele Girelli -@contact: gigi.ga90@gmail.com -""" - -import argparse -from ifpd2.asserts import enable_rich_assert -from ifpd2.scripts import arguments as ap -import os - - -def init_parser(subparsers: argparse._SubParsersAction) -> argparse.ArgumentParser: - parser = subparsers.add_parser( - __name__.split(".")[-1], - description=""" -Lorem ipsum dolor sit amet, consectetur adipisicing elit. Soluta, aspernatur, -natus. Possimus recusandae distinctio, voluptatem fuga delectus laudantium ut, -inventore culpa sit amet ullam officiis, tenetur nobis eius vitae dolore. -""", - formatter_class=argparse.RawDescriptionHelpFormatter, - help="Check integrity of a database.", - ) - - parser.add_argument( - "database", metavar="database", type=str, help="Path to database folder." - ) - parser = ap.add_version_option(parser) - parser.set_defaults(parse=parse_arguments, run=run) - - return parser - - -@enable_rich_assert -def parse_arguments(args: argparse.Namespace) -> argparse.Namespace: - assert os.path.isdir(args.database), f"database folder not found: {args.database}" - return args - - -@enable_rich_assert -def run(args: argparse.Namespace) -> None: - raise NotImplementedError diff --git a/ifpd2/scripts/extract_kmers.py b/ifpd2/scripts/extract_kmers.py new file mode 100644 index 00000000..492731c1 --- /dev/null +++ b/ifpd2/scripts/extract_kmers.py @@ -0,0 +1,54 @@ +""" +@author: Gabriele Girelli +@contact: gigi.ga90@gmail.com +""" + +from Bio.Seq import reverse_complement # type: ignore +import click # type: ignore +from ifpd2.const import CONTEXT_SETTINGS +from ifpd2.fasta import extract_kmers +from ifpd2.io import write_oligos +from ifpd2.oligo import select_by_GC +import logging +from os.path import isdir, isfile, join as path_join +from os.path import basename, normpath, splitext + + +@click.command( + name="extract_kmers", + context_settings=CONTEXT_SETTINGS, + help="Generate oligonucleotides K-mers from FASTA", +) +@click.argument("input_path", metavar="INPUT_FASTA", type=click.Path(exists=True)) +@click.argument("output_path", metavar="OUTPUT_DIRECTORY", type=click.Path(exists=True)) +@click.argument("kmer_size", metavar="KMER_LENGTH", type=click.INT) +def main(input_path: str, output_path: str, kmer_size: int) -> None: + if not isfile(input_path): + raise AssertionError + if not isdir(output_path): + raise AssertionError + + logging.info(f"Input : {input_path}") + logging.info(f"Output : {output_path}") + logging.info(f"Length : {kmer_size}") + + oligos_list = extract_kmers(input_path, kmer_size) + logging.info(f"Extracted {len(oligos_list)} sequences") + + valid_oligos = select_by_GC(oligos_list, kmer_size) + logging.info(f"{len(valid_oligos)} sequences with correct GC content") + + base, _ = splitext(basename(input_path)) + write_oligos( + path_join(normpath(output_path), f"{base}.GC35to85_Reference.fa"), + iter(valid_oligos), + ) + + write_oligos( + path_join(normpath(output_path), f"{base}.GC35to85_RevCompl.fa"), + ((h, reverse_complement(s)) for h, s in valid_oligos), + "writing rc", + ) + + logging.info("Done. :thumbs_up: :smiley:") + logging.shutdown() diff --git a/ifpd2/scripts/ifpd2.py b/ifpd2/scripts/ifpd2.py index 7ed522ab..0a6ec084 100644 --- a/ifpd2/scripts/ifpd2.py +++ b/ifpd2/scripts/ifpd2.py @@ -3,41 +3,41 @@ @contact: gigi.ga90@gmail.com """ -import argparse -from ifpd2.const import __version__ -from ifpd2.scripts import arguments as ap -from ifpd2 import scripts +import click # type: ignore +from ifpd2 import __version__ +from ifpd2.const import CONTEXT_SETTINGS +from ifpd2.scripts import db, extract_kmers, query, query2 import sys +import webbrowser -def default_parser(*args) -> None: - print("ifpd2 -h for usage details.") - sys.exit() - - -def main(): - parser = argparse.ArgumentParser( - description=f""" +@click.group( + name="ifpd2", + context_settings=CONTEXT_SETTINGS, + help=f"""\b Version: {__version__} Author: Gabriele Girelli Docs: http://ggirelli.github.io/ifpd2 Code: http://github.com/ggirelli/ifpd2 -Another iFISH probe design pipeline (II). -""", - formatter_class=argparse.RawDescriptionHelpFormatter, - ) - parser.set_defaults(parse=default_parser) - parser = ap.add_version_option(parser) +Another iFISH probe design pipeline (II).""", +) +@click.version_option(__version__) +def main(): + """Just a hook for the entry point. Silence is golden!""" + - subparsers = parser.add_subparsers( - title="sub-commands", - help="Access the help page for a sub-command with: sub-command -h", - ) +@click.command( + "_docs", + help="Open online documentation on your favorite browser.", +) +def open_documentation() -> None: + webbrowser.open("https://ggirelli.github.io/radiantkit/") + sys.exit() - scripts.dbchk.init_parser(subparsers) - scripts.query.init_parser(subparsers) - args = parser.parse_args() - args = args.parse(args) - args.run(args) +main.add_command(open_documentation) +main.add_command(extract_kmers.main) +main.add_command(db.run.main) +main.add_command(query.main) +main.add_command(query2.main) diff --git a/ifpd2/scripts/query.py b/ifpd2/scripts/query.py index 0970b6e5..69ee40ff 100644 --- a/ifpd2/scripts/query.py +++ b/ifpd2/scripts/query.py @@ -3,225 +3,188 @@ @contact: gigi.ga90@gmail.com """ -import argparse -from ifpd2.asserts import enable_rich_assert +import click # type: ignore +from ifpd2.const import CONTEXT_SETTINGS +from ifpd2.dataclasses import Folder, GenomicRegion, FreeEnergyInterval +from ifpd2.dataclasses import NonNegativeInteger, PositiveInteger +from ifpd2.dataclasses import PositiveFloat +from ifpd2.dataclasses import NonNegativeIntInterval +from ifpd2.dataclasses import QueryFocus, QueryWindow from ifpd2.walker import Walker from ifpd2.logging import add_log_file_handler from ifpd2.probe import OligoProbeBuilder from ifpd2.probe_set import OligoProbeSetBuilder import logging -import numpy as np # type: ignore -import os +from os.path import isdir, isfile, join as path_join +from os import mkdir +from typing import Optional, Tuple -def init_parser(subparsers: argparse._SubParsersAction) -> argparse.ArgumentParser: - parser = subparsers.add_parser( - __name__.split(".")[-1], - description=""" - Lorem ipsum dolor sit amet, consectetur adipisicing elit. Soluta, aspernatur, - natus. Possimus recusandae distinctio, voluptatem fuga delectus laudantium ut, - inventore culpa sit amet ullam officiis, tenetur nobis eius vitae dolore. - """, - formatter_class=argparse.RawDescriptionHelpFormatter, - help="Check integrity of a database.", - ) - - parser.add_argument( - "database", metavar="database", type=str, help="Path to database folder." - ) - parser.add_argument( - "chrom", - type=str, - help="Database feature to query for a probe.", - ) - - query = parser.add_argument_group("query arguments") - query.add_argument( - "--region", - metavar=("chromStart", "chromEnd"), - type=int, - nargs=2, - default=(0, np.inf), - help="""Start and end locations (space-separated) of the region of interest. - When a region is not provided (or start/end coincide), - the whole feature is queried.""", - ) - query.add_argument( - "-X", - metavar="probes", - type=int, - default=1, - help="""Number of probes to query for. Default: 1.""", - ) - query.add_argument( - "-N", - metavar="oligos", - type=int, - default=48, - help="""Number of oligos per probe. Default: 48.""", - ) - query.add_argument( - "-D", - metavar="dist", - type=float, - default=2, - help="""Minimum distance between consecutive oligos. Default: 2""", - ) - query.add_argument( - "--single", - action="store_const", - dest="single", - const=True, - default=False, - help="""Useful flag for - designing single probes. Same as "-X 1 -w 1". It overrides -X and -w, and - deactivate -W, if specified.""", - ) - - window = parser.add_argument_group("window arguments") - window.add_argument( - "-W", metavar="size", type=int, default=None, help="""Window size.""" - ) - window.add_argument( - "-w", - metavar="shift", - type=float, - default=0.1, - help="""Window shift as a percentage of window size. Default: 0.1""", - ) - - focus = parser.add_argument_group("focus region arguments") - focus.add_argument( - "-R", - metavar="size", - type=float, - default=8000, - help="""Central focus region size, either in nt or as fraction of window - size. Default: 8000""", - ) - focus.add_argument( - "-r", - metavar="step", - type=float, - default=1000, - help="""Central focus region step, either in nt or as fraction of central - focus region size. Default: 1000""", - ) - - filters = parser.add_argument_group("filter arguments") - filters.add_argument( - "-F", - metavar="nOT", - type=int, - nargs=2, - default=(0, 100), - help="""Acceptable range of off-targets. Default: (0,100)""", - ) - filters.add_argument( - "-G", - metavar="dG", - type=float, - nargs=2, - default=(0.0, 0.5), - help="""Acceptable range of secondary structure delta free energy. Either - as absolute kcal/mol os as a fraction of delta free energy of hybridization. - Default: (.0,.5)""", - ) - filters.add_argument( - "-o", - metavar="step", - type=float, - default=0.1, - help="""Step for oligo score relaxation. Default: .1""", - ) - filters.add_argument( - "-t", - metavar="temp", - type=float, - default=10.0, - help="""Melting temperature range half-width. Default: 10.""", - ) - filters.add_argument( - "-P", - metavar="size", - type=float, - default=10000, - help="""Maximum probe size in nt. Default: 10000""", - ) - filters.add_argument( - "-H", - metavar="size", - type=float, - default=0.1, - help="""Maximum hole size in a probe as fraction of probe size. - Default: .1""", - ) - - probe_set = parser.add_argument_group("probe set arguments") - probe_set.add_argument( - "-I", - metavar="oligos", - type=float, - default=0.5, - help="""Probe oligo intersection threshold as shared oligo fraction. - Default: .5""", - ) - - advanced = parser.add_argument_group("advanced arguments") - advanced.add_argument( - "-k", - metavar="length", - type=int, - help="""Oligo length in nt. Use this when all oligos in the - database have the same length, for optimization purposes.""", - ) - advanced.add_argument( - "-O", - metavar="outpath", - type=str, - default=".", - help="Path to output directory. Default to current folder.", - ) - advanced.add_argument( - "--threads", - type=int, - default=1, - help="Number of threads for parallelization. Default: 1", - ) - advanced.add_argument( - "--reuse", - action="store_const", - dest="reuse", - const=True, - default=False, - help="Avoid overwriting previous database walk, load instead.", - ) +@click.command( + name="query", + context_settings=CONTEXT_SETTINGS, + help="""Design FISH probes on a database chromosome. + When a --region is not specified, the whole chromosome is used. + Use -M for the number of probes, and -N for the number of oligos per probe. + Use -D to specify the minimum distance between consecutive oligos in a probe. - parser.set_defaults(parse=parse_arguments, run=run) + Use --single to access single-probe design. Same as "-X 1 -w 1", this option + overrides -X and -w, and ignores -W, if specified.""", +) +@click.argument("db_folder", type=click.Path(exists=True)) +@click.argument("chromosome", type=click.STRING) +@click.argument("output_path", metavar="OUTPUT", type=click.Path(exists=False)) +@click.option( + "--region", + type=click.INT, + nargs=2, + default=(0, -1), + help="Space-separate region start and end location.", +) +@click.option("-M", "--probes", type=click.INT, help="Design M probes.") +@click.option( + "-N", + "--oligos", + type=click.INT, + default=48, + help="N oligos per probe. Default: 48", +) +@click.option( + "-D", + "--dist", + type=click.INT, + default=2, + help="Consecutive oligo distance. Default: 2", +) +@click.option("--single", is_flag=True, help="Easy access to single probe design.") +@click.option("-W", "--window-size", type=click.INT) +@click.option( + "-w", + "--window-shift", + type=click.FLOAT, + default=0.1, + help="Shift as window fraction. Default: 0.1", +) +@click.option( + "-R", + "--focus-size", + type=click.FLOAT, + default=8e3, + help="""\b + Focus size in nt or window fraction. + Default: 8000""", +) +@click.option( + "-r", + "--focus-step", + type=click.FLOAT, + default=1e3, + help="""\b + Focus step in nt or focus fraction. + Default: 1000""", +) +@click.option( + "-F", + "--off-targets", + type=click.INT, + nargs=2, + default=(0, 99), + help="""Extremities of acceptable off-target range. + Default: [0, 99]""", +) +@click.option( + "-G", + "--free-energy", + type=click.FLOAT, + nargs=2, + default=(0.0, 0.5), + help="""Extremities of acceptable 2nd structure dG range, + in absolute kcal/mol or hybridization dG fraction. + Default: [0.0, 0.5]""", +) +@click.option( + "-o", + "--oligo-score-step", + type=click.FLOAT, + default=0.1, + help="Oligo score relaxation step. Default: 0.1", +) +@click.option( + "-t", + "--melting-half-width", + type=click.FLOAT, + default=10.0, + help="Melting range half-width. Default: 10.0", +) +@click.option( + "-P", + "--probe-size", + type=click.INT, + default=1e4, + help="Max probe size in nt. Default: 10000", +) +@click.option( + "-H", + "--gap-size", + type=click.FLOAT, + default=0.1, + help="""\b + Max gap size as probe size fraction. + Default: 0.1""", +) +@click.option( + "-I", + "--oligo-intersection", + type=click.FLOAT, + default=0.5, + help="""Probe intersection threshold as shared oligo fraction. + Default: .5""", +) +@click.option( + "-k", + "--oligo-length", + type=click.INT, +) +@click.option( + "--threads", + type=click.INT, + default=1, + help="Threads for parallelization. Default: 1", +) +def main( + db_folder: str, + chromosome: str, + output_path: str, + region: Tuple[int, int], + probes: Optional[int], + oligos: int, + dist: int, + single: bool, + window_size: Optional[int], + window_shift: float, + focus_size: float, + focus_step: float, + off_targets: Tuple[int, int], + free_energy: Tuple[float, float], + oligo_score_step: float, + melting_half_width: float, + probe_size: int, + gap_size: float, + oligo_intersection: float, + oligo_length: Optional[int], + threads: int, +) -> None: + settings = QuerySettings(db_folder, output_path) - return parser + if single: + probes = 1 + window_shift = 1.0 + window_size = None - -def assert_reusable(args): - assert_msg = " ".join( - [ - "output path should NOT direct towards an existing directory", - "or file. Use '--reuse' to load previous results.", - f"Provided path '{args.O}'", - ] - ) - assert not os.path.isfile(args.O), assert_msg + " leads to a file" - if not args.reuse: - assert not os.path.isdir(args.O), assert_msg + " leads to a directory." - - -@enable_rich_assert -def parse_arguments(args: argparse.Namespace) -> argparse.Namespace: - assert not all([isinstance(args.X, type(None)), isinstance(args.W, type(None))]) - args.start, args.end = args.region - args.start = int(args.start) - if not np.isfinite(args.end): - args.X = None + if probes is None and window_size is None: + raise AssertionError + if region[1] <= 0: + probes = None logging.info( " ".join( [ @@ -230,61 +193,90 @@ def parse_arguments(args: argparse.Namespace) -> argparse.Namespace: ] ) ) - args.end = int(args.end) if np.isfinite(args.end) else 0 - - if args.R > 1: - args.R = int(args.R) - if args.r > 1: - args.r = int(args.r) - - if args.single: - args.X = 1 - args.w = 1.0 - args.W = None - - assert_reusable(args) - return args + assert_reusable(settings.output_path) - -@enable_rich_assert -def run(args: argparse.Namespace) -> None: - - if not os.path.isdir(args.O): - os.mkdir(args.O) - add_log_file_handler("{0}/{1}.log".format(args.O, "ifpd2-main")) + if not isdir(settings.output_path): + mkdir(settings.output_path) + add_log_file_handler(f"{settings.output_path}/ifpd2-main.log") opb = OligoProbeBuilder() - opb.N = args.N - opb.D = args.D - opb.Tr = args.t - opb.Ps = args.P - opb.Ph = args.H - opb.Po = args.I - opb.k = args.k - opb.F = args.F - opb.Gs = (float(args.G[0]), float(args.G[1])) - opb.Ot = args.o + opb.N = PositiveInteger(oligos).n + opb.D = NonNegativeInteger(dist).n + opb.Tr = PositiveFloat(melting_half_width).n + opb.Ps = PositiveInteger(probe_size).n + opb.Ph = PositiveFloat(gap_size, 1).n + opb.Po = PositiveFloat(oligo_intersection, 1).n + opb.k = oligo_length + opb.F = NonNegativeIntInterval(*off_targets).astuple() + opb.Gs = FreeEnergyInterval(*free_energy).astuple() + opb.Ot = PositiveFloat(oligo_score_step, 1).n - opsb = OligoProbeSetBuilder(os.path.join(args.O, "probe_sets")) + opsb = OligoProbeSetBuilder(path_join(settings.output_path, "probe_sets")) logging.info(opb.get_prologue()) - ow = Walker(args.database) - ow.C = args.chrom - ow.S = args.start - ow.E = args.end - ow.X = args.X - ow.Ws = args.W - ow.Wh = args.w - ow.Rs = args.R - ow.Rt = args.r - ow.out_path = args.O - ow.reuse = args.reuse - ow.threads = args.threads + ow = Walker(settings.db_folder_path) + ow.C = chromosome + genomic_region = GenomicRegion(*region) + ow.S = genomic_region.start + ow.E = max(genomic_region.end, genomic_region.start) + ow.X = 1 if probes is None else PositiveInteger(probes).n + window = QueryWindow(window_size, window_shift) + ow.Ws = window.size + ow.Wh = window.shift + focus = QueryFocus(focus_size, focus_step) + ow.Rs = focus.size + ow.Rt = focus.step + ow.out_path = settings.output_path + ow.reuse = False + ow.threads = PositiveInteger(threads).n - ow.start(N=args.N, opb=opb, cfr_step=ow.Rt) + ow.start( + start_from_nt=genomic_region.start, + end_at_nt=genomic_region.end, + N=opb.N, + opb=opb, + cfr_step=ow.Rt, + ) opsb.build(ow.walk_results) opsb.export() + logging.info("Done. :thumbs_up: :smiley:") logging.shutdown() + + +class QuerySettings: + _db_folder: Folder + _output_path: Folder + + def __init__(self, db_folder: str, output_path: str): + super(QuerySettings, self).__init__() + self._db_folder = Folder(db_folder, True) + self._output_path = Folder(output_path, False) + + @property + def db_folder_path(self) -> str: + return self._db_folder.path + + @property + def output_path(self) -> str: + return self._output_path.path + + @property + def reusable(self) -> bool: + return False + + +def assert_reusable(output_path: str): + assert_msg = " ".join( + [ + "output path should NOT direct towards an existing directory", + "or file. Use '--reuse' to load previous results.", + f"Provided path '{output_path}'", + ] + ) + if isfile(output_path): + raise AssertionError(assert_msg + " leads to a file") + if isdir(output_path): + raise AssertionError(assert_msg + " leads to a directory.") diff --git a/ifpd2/scripts/query2.py b/ifpd2/scripts/query2.py new file mode 100644 index 00000000..a3800311 --- /dev/null +++ b/ifpd2/scripts/query2.py @@ -0,0 +1,261 @@ +""" +@author: Gabriele Girelli +@contact: gigi.ga90@gmail.com +""" + +import click # type: ignore +from ifpd2.const import CONTEXT_SETTINGS +from ifpd2.dataclasses import Folder +from ifpd2.dataclasses import PositiveInteger +from ifpd2.dataclasses import QueryWindow +from ifpd2.logging import add_log_file_handler +from ifpd2.database import DataBase +from ifpd2.region import GenomicRegionBuilder +from ifpd2.walker2 import ChromosomeWalker +import logging +from os.path import isdir, isfile +from os import mkdir +from typing import Optional, Tuple + + +@click.command( + name="query2", + context_settings=CONTEXT_SETTINGS, + help="""Design FISH probes on a database chromosome. + When a --region is not specified, the whole chromosome is used. + Use -M for the number of probes, and -N for the number of oligos per probe. + Use -D to specify the minimum distance between consecutive oligos in a probe. + + Use --single to access single-probe design. Same as "-X 1 -w 1", this option + overrides -X and -w, and ignores -W, if specified.""", +) +@click.argument("db_folder", type=click.Path(exists=True)) +@click.argument("chromosome", type=click.STRING) +@click.argument("output_path", metavar="OUTPUT", type=click.Path(exists=False)) +@click.option( + "--region", + type=click.INT, + nargs=2, + default=(0, -1), + help="Space-separate region start and end location.", +) +@click.option("-M", "--probes", type=click.INT, help="Design M probes.") +@click.option( + "-N", + "--oligos", + type=click.INT, + default=48, + help="N oligos per probe. Default: 48", +) +@click.option( + "-D", + "--dist", + type=click.INT, + default=2, + help="Consecutive oligo distance. Default: 2", +) +@click.option("--single", is_flag=True, help="Easy access to single probe design.") +@click.option("-W", "--window-size", type=click.INT) +@click.option( + "-w", + "--window-shift", + type=click.FLOAT, + default=0.1, + help="Shift as window fraction. Default: 0.1", +) +@click.option( + "-R", + "--focus-size", + type=click.FLOAT, + default=8e3, + help="""\b + Focus size in nt or window fraction. + Default: 8000""", +) +@click.option( + "-r", + "--focus-step", + type=click.FLOAT, + default=1e3, + help="""\b + Focus step in nt or focus fraction. + Default: 1000""", +) +@click.option( + "-F", + "--off-targets", + type=click.INT, + nargs=2, + default=(0, 99), + help="""Extremities of acceptable off-target range. + Default: [0, 99]""", +) +@click.option( + "-G", + "--free-energy", + type=click.FLOAT, + nargs=2, + default=(0.0, 0.5), + help="""Extremities of acceptable 2nd structure dG range, + in absolute kcal/mol or hybridization dG fraction. + Default: [0.0, 0.5]""", +) +@click.option( + "-o", + "--oligo-score-step", + type=click.FLOAT, + default=0.1, + help="Oligo score relaxation step. Default: 0.1", +) +@click.option( + "-t", + "--melting-half-width", + type=click.FLOAT, + default=10.0, + help="Melting range half-width. Default: 10.0", +) +@click.option( + "-P", + "--probe-size", + type=click.INT, + default=1e4, + help="Max probe size in nt. Default: 10000", +) +@click.option( + "-H", + "--gap-size", + type=click.FLOAT, + default=0.1, + help="""\b + Max gap size as probe size fraction. + Default: 0.1""", +) +@click.option( + "-I", + "--oligo-intersection", + type=click.FLOAT, + default=0.5, + help="""Probe intersection threshold as shared oligo fraction. + Default: .5""", +) +@click.option( + "-k", + "--oligo-length", + type=click.INT, +) +@click.option( + "--threads", + type=click.INT, + default=1, + help="Threads for parallelization. Default: 1", +) +def main( + db_folder: str, + chromosome: str, + output_path: str, + region: Tuple[int, int], + probes: Optional[int], + oligos: int, + dist: int, + single: bool, + window_size: Optional[int], + window_shift: Optional[float], + focus_size: float, + focus_step: float, + off_targets: Tuple[int, int], + free_energy: Tuple[float, float], + oligo_score_step: float, + melting_half_width: float, + probe_size: int, + gap_size: float, + oligo_intersection: float, + oligo_length: Optional[int], + threads: int, +) -> None: + settings = QuerySettings(db_folder, output_path) + + probes, window_size, window_shift = check_input( + single, probes, window_size, window_shift + ) + + if not isdir(settings.output_path): + mkdir(settings.output_path) + add_log_file_handler(f"{settings.output_path}/ifpd2-main.log") + + DB = DataBase(settings.db_folder_path) + + RB = GenomicRegionBuilder(DB.get_chromosome(chromosome.encode())) + if probes is not None: + region_set_list = RB.build_by_number(PositiveInteger(probes).n) + else: + window_size, window_shift = QueryWindow(window_size, window_shift).astuple() + if window_size is None or window_shift is None: + raise AssertionError + region_set_list = RB.build_by_size(window_size, window_shift) + + walker = ChromosomeWalker(DB, chromosome.encode()) + walker.walk_multiple_regions(region_set_list) + + # print((DB, RB, walker, region_set_list)) + + logging.info("Done. :thumbs_up: :smiley:") + logging.shutdown() + + +def check_input( + single: bool, + probes: Optional[int], + window_size: Optional[int], + window_shift: Optional[float], +) -> Tuple[Optional[int], Optional[int], Optional[float]]: + if single: + probes = 1 + window_shift = None + window_size = None + + if probes is None and window_size is None: + raise AssertionError + if probes is not None and window_size is not None: + logging.warning("cannot combine -X and -W. Using -X.") + window_size = None + window_shift = None + if window_size is not None and window_shift is None: + window_shift = 1 + + return (probes, window_size, window_shift) + + +class QuerySettings: + _db_folder: Folder + _output_path: Folder + + def __init__(self, db_folder: str, output_path: str): + super(QuerySettings, self).__init__() + self._db_folder = Folder(db_folder, True) + self._output_path = Folder(output_path, False) + + @property + def db_folder_path(self) -> str: + return self._db_folder.path + + @property + def output_path(self) -> str: + return self._output_path.path + + @property + def reusable(self) -> bool: + return False + + +def assert_reusable(output_path: str): + assert_msg = " ".join( + [ + "output path should NOT direct towards an existing directory", + "or file. Use '--reuse' to load previous results.", + f"Provided path '{output_path}'", + ] + ) + if isfile(output_path): + raise AssertionError(assert_msg + " leads to a file") + if isdir(output_path): + raise AssertionError(assert_msg + " leads to a directory.") diff --git a/ifpd2/tests/__init__.py b/ifpd2/tests/__init__.py new file mode 100644 index 00000000..22bab5ef --- /dev/null +++ b/ifpd2/tests/__init__.py @@ -0,0 +1,8 @@ +""" +@author: Gabriele Girelli +@contact: gigi.ga90@gmail.com +""" + +from ifpd2.tests import test_scripts_db + +__all__ = ["test_scripts_db"] diff --git a/ifpd2/tests/test_scripts_db.py b/ifpd2/tests/test_scripts_db.py new file mode 100644 index 00000000..91959330 --- /dev/null +++ b/ifpd2/tests/test_scripts_db.py @@ -0,0 +1,8 @@ +""" +@author: Gabriele Girelli +@contact: gigi.ga90@gmail.com +""" + + +def test_placeholder(): + """Test the scripts here!""" diff --git a/ifpd2/walker.py b/ifpd2/walker.py index 7031012d..20024ad7 100644 --- a/ifpd2/walker.py +++ b/ifpd2/walker.py @@ -13,16 +13,17 @@ from pathlib import Path import shutil from tqdm import tqdm # type: ignore -from typing import Dict, List +from typing import Dict, List, Optional, Union from ifpd2 import asserts as ass from ifpd2.logging import add_log_file_handler -from ifpd2.database import Database -from ifpd2.oligo import Oligo, OligoGroup +from ifpd2.database import DataBase +from ifpd2.oligo import OligoGroup from ifpd2.probe import OligoProbeBuilder +from ifpd2.walker2 import ChromosomeWalker -class GenomicWindowSet(object): +class GenomicWindowSet: """Genomic window manager.""" _window_sets = None @@ -32,20 +33,17 @@ class GenomicWindowSet(object): E = int(3500000) # Region end coordinate (excluded) X = 20 # Number of probes to design - Ws = None # Window size (used when X is not provided) - Wh = 0.1 # Window shift (as a percentage of the window size) + Ws: Optional[int] = None # Window size (used when X is not provided) + Wh: Optional[float] = 0.1 # Window shift (as a percentage of the window size) - Rs = int(8000) # Region focus size, either in nt (Rs > 1) + Rs: Union[int, float] = int(8000) # Region focus size, either in nt (Rs > 1) # or fraction of Ws (0 1) + Rt: Union[int, float] = int(1000) # Region focus step, either in nt (Rt > 1) # or fraction of Rs (0 self.E: + raise AssertionError ass.ert_multiTypes(self.X, [int, type(None)], "X") ass.ert_multiTypes(self.Ws, [int, type(None)], "Ws") @@ -108,14 +107,14 @@ def _assert(self): ass.ert_inInterv(self.Wh, 0, 1, "Wh") ass.ert_multiTypes(self.Rs, [int, float], "Rs") - if isinstance(self.Rs, int): - assert self.Rs > 1 + if self.Rs > 1: + self.Rs = int(self.Rs) else: ass.ert_inInterv(self.Rs, 0, 1, "Rs") ass.ert_multiTypes(self.Rt, [int, float], "Rt") - if isinstance(self.Rt, int): - assert self.Rt > 1 + if self.Rt > 1: + self.Rt = int(self.Rt) else: ass.ert_inInterv(self.Rt, 0, 1, "Rt") @@ -124,18 +123,20 @@ def _init_windows(self): if not os.path.isdir(os.path.join(self.out_path, "window_sets")): os.mkdir(os.path.join(self.out_path, "window_sets")) - if self.S == self.E: - assert not isinstance(self.Ws, type(None)), " ".join( - [ - "During full-chromosome search, provide a window size.", - "I.e., it is not possible to design X probes.", - ] + if self.S == self.E and isinstance(self.Ws, type(None)): + raise AssertionError( + " ".join( + [ + "During full-chromosome search, provide a window size.", + "I.e., it is not possible to design X probes.", + ] + ) ) if isinstance(self.X, int): self.Ws = ( self.E - self.S - if 1 == self.X + if self.X == 1 else np.floor((self.E - self.S) / (self.X + 1)).astype("i") ) @@ -157,7 +158,7 @@ def __update_focus(self): def __mk_all_window_sets(self): # Prepare all window sets in a region of interest window_starts = np.floor(np.arange(self.S, self.E, self.Ws)).astype("i") - if 0 != (self.E - self.S) % self.Ws or 1 != len(window_starts): + if (self.E - self.S) % self.Ws != 0 or len(window_starts) != 1: window_starts = window_starts[:-1] window_mids = (window_starts + self.Ws / 2).reshape((window_starts.shape[0], 1)) @@ -175,11 +176,9 @@ def __mk_all_window_sets(self): np.floor(window_mids + self.Rs / 2), ] ) - self.__focus_on_center = True else: nans = np.array([np.nan for x in range(window_mids.shape[0])]) central_regions = np.vstack([nans, nans]).transpose() - self.__focus_on_center = False window_sets = [] for i in range(len(np.arange(0, 1, self.Wh))): @@ -204,10 +203,8 @@ def __mk_first_window(self): mid = self.S + self.Ws / 2 if self.Rs < self.Ws: cstart, cend = (np.floor(mid - self.Rs / 2), np.floor(mid + self.Rs / 2)) - self.__focus_on_center = True else: cstart, cend = (np.nan, np.nan) - self.__focus_on_center = False return [[self.S, mid, self.S + self.Ws, cstart, cend, 0, 0]] def _add_window(self): @@ -222,7 +219,7 @@ def _add_window(self): new_window_id = 0 new_set_id = self.window_sets["s"].max() + 1 - if 0 != len(non_overlapping_group_ids): + if len(non_overlapping_group_ids) != 0: new_set_id = gData[non_overlapping_group_ids].min() new_window_id = ( self.window_sets[self.window_sets["s"] == new_set_id]["w"].max() + 1 @@ -251,18 +248,20 @@ def export_window_set(self): class Walker(GenomicWindowSet): """Walker walks through the oligos stored in an ifpd2 database, assigns them to windows based on user-defined parameters, and then builds - probe candidates.""" + probe candidates. + """ out_path = "." reuse = False _threads = 1 + __db: DataBase __current_oligos: List = [] __walk_results: Dict = {} def __init__(self, db_path, logger=logging.getLogger()): GenomicWindowSet.__init__(self) - self.__db = Database(db_path) + self.__db = DataBase(db_path) self.logger = logger @property @@ -272,8 +271,7 @@ def threads(self): @threads.setter def threads(self, threads): ass.ert_type(threads, int, threads) - threads = max(1, threads) - threads = min(mp.cpu_count(), threads) + threads = max(1, min(threads, mp.cpu_count())) self._threads = threads @property @@ -281,7 +279,7 @@ def current_oligos(self): return self.__current_oligos def remove_oligos_starting_before(self, pos): - self.__current_oligos = [o for o in self.current_oligos if o.start >= pos] + self.__current_oligos = [o for o in self.current_oligos if o["start"] >= pos] @property def window_set_path(self): @@ -331,13 +329,16 @@ def config(self): def _assert(self): GenomicWindowSet._assert(self) - assert os.path.isdir(self.out_path) + if not os.path.isdir(self.out_path): + raise AssertionError - def start(self, *args, **kwargs): + def start(self, *args, start_from_nt: int = 0, end_at_nt: int = -1, **kwargs): self._assert() self._init_windows() self.print_prologue() - self.__start_walk(*args, **kwargs) + self.__start_walk( + *args, start_from_nt=start_from_nt, end_at_nt=end_at_nt, **kwargs + ) def print_prologue(self): @@ -365,71 +366,67 @@ def walk_destination(self): return np.inf return self.E - def __finished_parsing(self, line, oligo_start, oligo_end, DBHpb, args, kwargs): + def __finished_parsing(self, record, DBHpb, args, kwargs): # Return: # None to stop parsing # True to parse in current window # Parsed output to append it - if oligo_start >= self.current_window["end"]: - # DBHpb.clear() - - parsed_output = self.__process_window_async( - self.current_oligos, - self.current_window, - self.fprocess, - self.fpost, - *args, - opath=self.window_path, - loggerName=self.logger.name, - **kwargs, - ) + if record["start"] < self.current_window["end"]: + return (None, "continue") + # DBHpb.clear() - if self.reached_last_window: - self.logger.info("Reached last window") - return (None, "break") + parsed_output = self.__process_window_async( + self.current_oligos, + self.current_window, + self.fprocess, + self.fpost, + *args, + opath=self.window_path, + loggerName=self.logger.name, + **kwargs, + ) - self.go_to_next_window() - self._preprocess_window() - self._load_windows_until_next_to_do() - if self.reached_last_window and self._window_done(): - self.logger.info("Reached last window and done") - return (None, "break") + if self.reached_last_window: + self.logger.info("Reached last window") + return (None, "break") - if 0 != len(self.current_oligos): - self.remove_oligos_starting_before(self.current_window["start"]) + self.go_to_next_window() + self._preprocess_window() + self._load_windows_until_next_to_do() + if self.reached_last_window and self._window_done(): + self.logger.info("Reached last window and done") + return (None, "break") - return (parsed_output, "append") - return (None, "continue") + if len(self.current_oligos) != 0: + self.remove_oligos_starting_before(self.current_window["start"]) + + return (parsed_output, "append") - def __parse_line(self, line, oligo_start, oligo_end, DBHpb, args, kwargs): - if oligo_start >= self.current_window["start"]: + def __parse_line(self, record, DBHpb, args, kwargs): + if record["start"] >= self.current_window["start"]: parsing_output, parsing_status = self.__finished_parsing( - line, oligo_start, oligo_end, DBHpb, args, kwargs + record, DBHpb, args, kwargs ) - if parsing_status == "continue": - if oligo_end > self.walk_destination: # End reached - self.logger.info("Reached destination") - return (None, "break") + if parsing_status != "continue": + return (parsing_output, parsing_status) + if record["end"] > self.walk_destination: # End reached + self.logger.info("Reached destination") + return (None, "break") - oligo = Oligo(line, self.r) - self.fparse(oligo, *args, **kwargs) + self.fparse(record, *args, **kwargs) - if not np.isnan(oligo.score): - self.current_oligos.append(oligo) + if not np.isnan(record["score"]): + self.current_oligos.append(record) - self.rw += 1 - else: - return (parsing_output, parsing_status) + self.rw += 1 return (None, "continue") def __parse_database(self, DBHpb, args, kwargs): exec_results = [] - for line in DBHpb: - oligo_start, oligo_end = [int(x) for x in line.strip().split("\t")[2:4]] - + for record in DBHpb: parsing_output, parsing_status = self.__parse_line( - line, oligo_start, oligo_end, DBHpb, args, kwargs + record, DBHpb, args, kwargs ) if parsing_status == "break": @@ -438,7 +435,7 @@ def __parse_database(self, DBHpb, args, kwargs): exec_results.append(parsing_output) self.r += 1 - if 0 != len(self.current_oligos): + if len(self.current_oligos) != 0: exec_results.append( self.__process_window_async( self.current_oligos, @@ -456,13 +453,15 @@ def __parse_database(self, DBHpb, args, kwargs): def __end_walk(self, exec_results): for promise in exec_results: s, w, results = promise.get() - if s in self.walk_results.keys(): + if s in self.__walk_results.keys(): self.__walk_results[s][w] = results else: self.__walk_results[s] = {w: results} - def __start_walk(self, *args, **kwargs): - self.pool = mp.Pool(np.min([self.threads, mp.cpu_count()])) + def __start_walk( + self, *args, start_from_nt: int = 0, end_at_nt: int = -1, **kwargs + ): + self.pool = mp.Pool(max(1, min(self.threads, mp.cpu_count()))) self.logger.info(f"Prepared a pool of {self.threads} threads.") self._preprocess_window() @@ -475,21 +474,26 @@ def __start_walk(self, *args, **kwargs): self.r = 0 # Record ID self.rw = 0 # Walk step counter - DBHpb = tqdm(self.__db.buffer(self.C), desc="Parsing records", leave=None) + DBHpb = tqdm( + ChromosomeWalker(self.__db, self.C.encode()).buffer( + start_from_nt, end_at_nt + ), + total=self.__db.chromosome_recordnos[self.C.encode()], + desc="Parsing records", + leave=False, + ) parsing_output = self.__parse_database(DBHpb, args, kwargs) self.logger.info(f"Parsed {self.rw}/{self.r} records.") self.__end_walk(parsing_output) DBHpb.close() self.pool.close() - self.pool.join() def _window_done(self): s = int(self.current_window["s"]) w = int(self.current_window["w"]) - if s in self.walk_results.keys(): - if w in self.walk_results[s].keys(): - return isinstance(self.walk_results[s][w], list) + if s in self.walk_results.keys() and w in self.walk_results[s].keys(): + return isinstance(self.walk_results[s][w], list) return False def _load_windows_until_next_to_do(self): @@ -520,12 +524,8 @@ def _preprocess_window_do(self): wid = int(self.current_window["w"]) self.__walk_results[sid][wid] = self.fimport(self.window_path) return - else: - shutil.rmtree(self.window_path) - os.mkdir(self.window_path) - else: - shutil.rmtree(self.window_path) - os.mkdir(self.window_path) + shutil.rmtree(self.window_path) + os.mkdir(self.window_path) def _preprocess_window(self): # Preprocess current window @@ -591,6 +591,7 @@ def process_window_async( def __process_window_async(self, *args, **kwargs): if self.pool is not None: return self.pool.apply_async(Walker.process_window_async, args, kwargs) + return None @staticmethod def process_window( @@ -605,7 +606,7 @@ def process_window( **kwargs, ): # Process oligos from window using fprocess. Then, post-process them - # with fopost. Requires at least N oligos to proceeed. If opath is + # with fopost. Requires at least N oligos to proceed. If opath is # specified, a ".done" file is touched upon successful postprocessing. logger = logging.getLogger(loggerName) kwargs["loggerName"] = loggerName @@ -641,13 +642,17 @@ def process_window( return (int(window["s"]), int(window["w"]), results) @staticmethod - def fparse(oligo, opb=None, *args, **kwargs): - oligo.add_score(opb.F, opb.Gs) + def fparse(record, opb=None, *args, **kwargs): + record.add_score(opb.F, opb.Gs) + # if record["off_target_no"]<100: + # print((record._data, opb.F, opb.Gs)) + # print(record.to_dataframe()) @staticmethod def fprocess(oGroup, window, *args, **kwargs): opb = copy.copy(kwargs["opb"]) - assert isinstance(opb, OligoProbeBuilder) + if not isinstance(opb, OligoProbeBuilder): + raise AssertionError logger = logging.getLogger(kwargs["loggerName"]) probe_list = opb.start(oGroup, window, kwargs["cfr_step"], logger) reduced_probe_list = opb.reduce_probe_list(probe_list) @@ -662,9 +667,10 @@ def fimport(path, *args, **kwargs): @staticmethod def fpost(results, opath, *args, **kwargs): - assert isinstance(kwargs["opb"], OligoProbeBuilder) + if not isinstance(kwargs["opb"], OligoProbeBuilder): + raise AssertionError logger = logging.getLogger(kwargs["loggerName"]) - if 0 == len(results): + if len(results) == 0: logger.critical(f"Built {len(results)} oligo probe candidates") logger.handlers = logger.handlers[:-1] else: diff --git a/ifpd2/walker2.py b/ifpd2/walker2.py index 9368857c..68531692 100644 --- a/ifpd2/walker2.py +++ b/ifpd2/walker2.py @@ -3,57 +3,190 @@ @contact: gigi.ga90@gmail.com """ +from ifpd2.database import DataBase, Record +from ifpd2.region import GenomicRegion +import itertools import logging -import pandas as pd # type: ignore -from typing import Tuple, Union - - -class GenomicWindowSet(object): - _window_data: pd.DataFrame = pd.DataFrame( - columns=[ - "set_id", - "window_id", - "start", - "end", - "focus_start", - "focus_end", - ] - ) - _window_id: int = -1 - - feature: str # Chromosome - region: Tuple[int, int] - - n_probes: int - window_size: int - window_shift: float - - # Either in nt (x>1) or fraction of window_size (01) or fraction of focus_size (0 bool: - return self._growing + +class ChromosomeWalker: + """docstring for Walker""" + + __chromosome: bytes + __db: DataBase + __IH: IO + + def __init__(self, db: Union[DataBase, str], chromosome: bytes): + super(ChromosomeWalker, self).__init__() + self.__db = DataBase(db) if isinstance(db, str) else db + if chromosome not in self.__db._chromosomes.keys(): + raise AssertionError + self.__IH = open( + os.path.join(self.__db._root, f"{chromosome.decode()}.bin"), "rb" + ) + self.__chromosome = chromosome @property - def reached_last_window(self) -> bool: - return (self._window_id + 1) == self._window_data.shape[0] + def db(self) -> DataBase: + return self.__db - def init_windows_for_n_probes(self, n_probes: int) -> None: - if 0 < self._window_data.shape[0]: - logging.warning("cannot re-initalize windows.") - return + def __jump_to_bin(self, start_from_nt: int = 0) -> None: + """Move buffer pointer to the first record of a bin. + + Keyword Arguments: + start_from_nt {int} -- position in nucleotides (default: {0}) + """ + position_in_bytes = self.__db._chromosomes.get_chromosome( + self.__chromosome + ).index[start_from_nt] + self.__IH.seek(position_in_bytes) + + def read_next_record(self) -> bytes: + """Read the next record. + + The buffer pointer moves to the start of the following record. + + Returns: + bytes -- record bytes + """ + return self.__IH.read(self.__db.record_byte_size) + + # def read_previous_record(self) -> bytes: + # """Read the previous record. + + # The buffer pointer does not move. + + # Returns: + # bytes -- record bytes + # """ + # self.rewind() + # return self.read_next_record() + + def read_next_record_and_rewind(self) -> bytes: + """Reads the next record. + + The buffer pointer does not move. + + Returns: + bytes -- record bytes + """ + record = self.read_next_record() + self.rewind() + return record - def init_windows_by_size(self, size: int, shift: float) -> None: - if 0 < self._window_data.shape[0]: - logging.warning("cannot re-initalize windows.") + def next_record_exists(self) -> bool: + """Tries reading the next record. + + Returns: + bool -- whether next record exists + """ + return len(self.read_next_record_and_rewind()) != 0 + + def rewind(self) -> None: + """Rewind of one record. + + The buffer pointer moves to the beginning of the previous record. + """ + self.__IH.seek(max(self.__IH.tell() - self.__db.record_byte_size, 0)) + + # def skip(self) -> None: + # """Skip one record. + + # The buffer pointer moves to the beginning of the following record. + # """ + # self.__IH.seek(self.__IH.tell() + self.__db.record_byte_size) + + def fastforward(self, start_from_nt: int) -> None: + """Jump to the first record at a given position. + + First the buffer pointer is moved to the beginning of the bin containing the + start_from_nt position. Then, records are read an parsed until their start is + greater than the start_from_nt value. Finally, the buffer pointer is moved to + the beginning of the last parsed record. + + Arguments: + IH {IO} -- database input handle + chromosome {bytes} -- chromosome label + start_from_nt {int} -- position to fastforward to (in nucleotides) + """ + if start_from_nt == 0: + self.__IH.seek(0) return + self.__jump_to_bin(start_from_nt) + + record_start = 0 + while record_start < start_from_nt: + if self.next_record_exists(): + record_start = Record(self.read_next_record(), self.__db.dtype)["start"] + else: + logging.warning( + " ".join( + [ + "the specified location", + f"({self.__chromosome.decode()}:{start_from_nt})", + "is outside the database.", + ] + ) + ) + return + + def buffer(self, start_from_nt: int = 0, end_at_nt: int = -1) -> Iterator[Record]: + """Buffer a chromosome's records. + + Buffer records from a chromosome within the specified region. + To buffer the whole records, specify a [0, -1] region. + + Keyword Arguments: + start_from_nt {int} -- region starting position (default: {0}) + end_at_nt {int} -- region end position (default: {-1}) + + Yields: + Iterator[Record] -- parsed record + """ + self.fastforward(start_from_nt) + record = self.read_next_record() + while len(record) != 0: + parsed_record = Record(record, self.__db.dtype) + if parsed_record["start"] > end_at_nt and end_at_nt > 0: + break + yield parsed_record + record = self.read_next_record() + + def walk_single_region(self, region: GenomicRegion) -> Iterator[List[Record]]: + if region.chromosome != self.__chromosome: + raise AssertionError + focus_start, focus_end = region.focus + record_list = list(self.buffer(focus_start, focus_end)) + yield record_list + while region.can_increase_focus(): + region.increase_focus() + new_focus_start, new_focus_end = region.focus + record_list = list( + itertools.chain( + *[ + list(self.buffer(new_focus_start, focus_start)), + record_list, + list(self.buffer(focus_end, new_focus_end)), + ] + ) + ) + yield record_list + focus_start, focus_end = region.focus + + def walk_multiple_regions(self, region_set_list: List[List[GenomicRegion]]) -> None: + for region_set_idx in range(len(region_set_list)): + region_set = region_set_list[region_set_idx] + for region_idx in range(len(region_set)): + region = region_set[region_idx] + for record_set in self.walk_single_region(region): + logging.info( + " ".join( + [ + f"Window {region_set_idx}.{region_idx}", + f"({region.focus}):", + f"read {len(record_set)} records", + ] + ) + ) diff --git a/ignore-spelling-words.txt b/ignore-spelling-words.txt new file mode 100644 index 00000000..dfb34046 --- /dev/null +++ b/ignore-spelling-words.txt @@ -0,0 +1 @@ +ot \ No newline at end of file diff --git a/poetry.lock b/poetry.lock index 7f186c94..18035302 100644 --- a/poetry.lock +++ b/poetry.lock @@ -1,3 +1,73 @@ +[[package]] +name = "atomicwrites" +version = "1.4.0" +description = "Atomic file writes." +category = "dev" +optional = false +python-versions = ">=2.7, !=3.0.*, !=3.1.*, !=3.2.*, !=3.3.*" 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100644 --- a/pyproject.toml +++ b/pyproject.toml @@ -1,12 +1,12 @@ [tool.poetry] name = "ifpd2" -version = "1.0.0-alpha" +version = "1.0.1a1" description = "An iFISH probe design pipeline (II)" authors = ["Gabriele Girelli "] license = "MIT" readme = "README.md" -homepage = "https://github.com/ggirelli/iFISH-Probe-Design" -repository = "https://github.com/ggirelli/iFISH-Probe-Design" +homepage = "https://github.com/ggirelli/ifpd2" +repository = "https://github.com/ggirelli/ifpd2" keywords = ["biology", "cell", "DNA", "RNA", "FISH", "fluorescence", "hybridization"] classifiers = [ "Development Status :: 3 - Alpha", @@ -16,24 +16,38 @@ classifiers = [ "License :: OSI Approved :: MIT License", "Operating System :: Unix", "Operating System :: POSIX :: Linux", - "Programming Language :: Python :: 3.7", "Programming Language :: Python :: 3.8", + "Programming Language :: Python :: 3.9", + "Typing :: Typed", ] include = [ "CHANGELOG.md", - "LICENSE" + "LICENSE", + "test_data" ] [tool.poetry.dependencies] -python = "^3.7.1" +python = "^3.8" +biopython = "^1.79" +click = "^8.0.1" numpy = "^1.20.1" pandas = "^1.2.2" -rich = "^9.10.0" +rich = ">=9.10,<11.0" tqdm = "^4.58.0" +[tool.poetry.dev-dependencies] +pytest = "^6.2.5" +black = "^21.12b0" + +[tool.vulture] +paths = ["ifpd2"] +min_confidence = 80 +verbose = true + [build-system] requires = ["poetry>=0.12"] build-backend = "poetry.masonry.api" [tool.poetry.scripts] "ifpd2" = "ifpd2.scripts.ifpd2:main" +"ifpd2-autocomplete" = "ifpd2.scripts.autocomplete:main" diff --git a/test_data/test.dump.txt b/test_data/test.dump.txt new file mode 100644 index 00000000..e7ce0a8b --- /dev/null +++ b/test_data/test.dump.txt @@ -0,0 +1,501 @@ +name chromosome start end sequence gc_content off_target_no Tm_dG Tm_dH Tm_dS Tm ss_dG +candidate_22250312 chr16 3109155 3109195 AAAACAAAGAGTTGGGCCGGGCGTGGTGGCACACACCTTT 0.55 1059 -57.27 -323.1 -0.857 51.21 -3.911 +candidate_21838028 chr16 4109470 4109510 AAAACAAAACTAATCCCCAACTCTCTTTCCCTGATCAAAT 0.35 0 -46.991 -306.4 -0.836 40.0 1.524 +candidate_21775575 chr16 4115534 4115574 AAAACAAAACACATTCCCAGGCTGGATTTGGCTCTTGGCC 0.475 0 -53.055 -316.9 -0.851 46.58 -2.881 +candidate_22556430 chr16 4139209 4139249 AAAACAACACCTGCTCTAGACTGCAGCAACACAAACTGAA 0.425 0 -51.436 -317.7 -0.859 44.17 -1.908 +candidate_22274554 chr16 4153705 4153745 AAAACAAAGCATGAGAGAGGGAGGCAGGCAGTACATAAGC 0.475 0 -51.935 -316.4 -0.853 45.23 -0.904 +candidate_21896771 chr16 4154836 4154876 AAAACAAAAGGCAACTTACCATATTTGGCACAGTGGTGAC 0.4 0 -49.881 -315.4 -0.856 42.48 -3.608 +candidate_22488479 chr16 4169917 4169957 AAAACAACAAACTACTTTCACCAGCATGTCATCCACTTTG 0.375 0 -48.774 -315.1 -0.859 41.03 0.444 +candidate_22302074 chr16 5109235 5109275 AAAACAAAGGGAACTGGGGTTGAAGAGATGGCTCAGTGGT 0.475 1031 -52.277 -312.4 -0.839 46.35 -1.585 +candidate_22179958 chr16 5111686 5111726 AAAACAAACGAAACACCATTGCTGGGTGCCAGGAGAGGGA 0.5 0 -54.245 -317.5 -0.849 48.11 -2.092 +candidate_21898022 chr16 5142581 5142621 AAAACAAAAGGCTAGCCTTGGATGTATAGCAAGACTGTCT 0.4 2 -49.116 -311.1 -0.845 42.19 -2.152 +candidate_22120338 chr16 5155136 5155176 AAAACAAACACACTCAAGAAACTGTTCCACTCATGGAGAA 0.375 0 -48.786 -312.6 -0.851 41.43 -1.569 +candidate_21735207 chr16 5178254 5178294 AAAACAAAACAAAGAGCTAGGCACTCGGGAGGTTGAGGCA 0.475 10 -53.045 -317.2 -0.852 46.51 -0.522 +candidate_22246691 chr16 5178259 5178299 AAAACAAAGAGCTAGGCACTCGGGAGGTTGAGGCAGGAAG 0.525 15 -53.88 -318.5 -0.853 47.56 -0.522 +candidate_21884633 chr16 5196409 5196449 AAAACAAAAGCCAGGCATGATGGTACGTTGGAAGTTGGAG 0.45 1 -51.815 -317.8 -0.858 44.74 -0.409 +candidate_21823586 chr16 6111442 6111482 AAAACAAAACCCCTTAAATTGGAGTGCACCCCTTCACGGG 0.475 0 -52.531 -315.6 -0.848 46.13 -1.232 +candidate_22244228 chr16 6117975 6118015 AAAACAAAGAGAGAAACACACAGAGAGAAACACAGAGAGA 0.375 1283 -47.962 -311.9 -0.851 40.5 998.226 +candidate_22522157 chr16 6119212 6119252 AAAACAACAACAACACCTGTTGTAAATAGACACAAGGCAA 0.35 0 -48.439 -313.4 -0.854 40.77 -4.078 +candidate_21797204 chr16 6123369 6123409 AAAACAAAACATCACAGAACCTGGCAGATGGCTTCCTATG 0.425 0 -50.29 -314.6 -0.852 43.22 -1.002 +candidate_22414716 chr16 6125809 6125849 AAAACAAATGATTGGCATGTTCAGTGGAGGGCCTGTTGGT 0.45 0 -52.316 -314.3 -0.845 45.97 -1.825 +candidate_22361207 chr16 6135546 6135586 AAAACAAATACGAGATCAGCCTGTTGGTACACTGCCAATA 0.4 0 -49.583 -313.8 -0.852 42.35 -1.618 +candidate_22375839 chr16 6136459 6136499 AAAACAAATATGCTCCCAAATGGCTTGTGTGTTTATTACC 0.35 0 -47.583 -311.8 -0.852 39.94 -1.434 +candidate_22354848 chr16 6143948 6143988 AAAACAAATAATGGGAAATGCTGGCAAGGGCTCAGGCAAA 0.425 3 -51.661 -313.8 -0.845 45.11 -0.842 +candidate_21915805 chr16 6147626 6147666 AAAACAAAATAAAACAAAACCATGCAGCGGATGGATTCTG 0.35 12 -48.485 -315.4 -0.861 40.53 -1.722 +candidate_21817435 chr16 6147636 6147676 AAAACAAAACCATGCAGCGGATGGATTCTGGGGAATGACA 0.45 1 -52.331 -315.4 -0.848 45.8 -1.722 +candidate_21734070 chr16 6153316 6153356 AAAACAAAACAAAGAAACTCCATCTTTGGGTCTAGTCATG 0.35 2 -47.031 -311.0 -0.851 39.36 -3.188 +candidate_22218001 chr16 6153321 6153361 AAAACAAAGAAACTCCATCTTTGGGTCTAGTCATGCCCAC 0.425 0 -49.876 -313.1 -0.849 42.94 -3.188 +candidate_21874668 chr16 6176861 6176901 AAAACAAAAGATCTGCTAACATCCTCCCCTCCCCTCCCCT 0.5 0 -52.078 -308.2 -0.826 46.94 0.494 +candidate_22454116 chr16 6181586 6181626 AAAACAAATTGGGCTACTGGGATGGCTCAGTGGGAAAGGC 0.5 243 -53.275 -315.6 -0.846 47.19 -2.228 +candidate_22557039 chr16 7141448 7141488 AAAACAACACGCGGCTCCGTGAACACAATTGCATTGAAAA 0.425 0 -53.319 -324.7 -0.875 45.39 -4.601 +candidate_22197538 chr16 7145407 7145447 AAAACAAACTCTTTAGAGCTGGTGAATGCTTGTTCTCAGT 0.375 0 -48.738 -312.8 -0.851 41.34 -0.981 +candidate_22202360 chr16 8100518 8100558 AAAACAAACTGTATAGAGGGTTTGTCCCTGTGCAGAAGAC 0.425 0 -49.631 -313.6 -0.851 42.55 -3.325 +candidate_22292665 chr16 8111403 8111443 AAAACAAAGGACAGGCTGCAACCAGCAACTCTGCTTGCTG 0.5 0 -54.637 -322.7 -0.864 47.69 -3.551 +candidate_22530532 chr16 8117580 8117620 AAAACAACAACCCACTTTGGGTCTATCTCTGTCAATGCTC 0.425 0 -49.945 -314.1 -0.852 42.87 -3.135 +candidate_21864435 chr16 8132196 8132236 AAAACAAAAGAATATAACTTCTCAGCACCTCATGGAACCT 0.35 753 -47.016 -308.1 -0.842 39.78 -1.008 +candidate_21888583 chr16 8147690 8147730 AAAACAAAAGCTGTGTGACATACTGTGGCCCACTGCAGCT 0.475 13 -53.712 -319.2 -0.856 47.02 -2.936 +candidate_22185583 chr16 8163848 8163888 AAAACAAACTAAAGGAGAGTAAAGAAGAGTCACCAACCCT 0.375 0 -47.567 -308.0 -0.84 40.6 -0.146 +candidate_22525042 chr16 9111319 9111359 AAAACAACAACAATAACAGCAACAGCAGCAGCAGCAGCAA 0.425 1165 -52.976 -322.0 -0.867 45.4 -2.584 +candidate_21686674 chr16 9163163 9163203 AAAACAAAACAAAACACTTGAGGCAGGGAGATAGCTTAGT 0.375 10 -48.627 -311.2 -0.847 41.45 -1.009 +candidate_21781230 chr16 9163168 9163208 AAAACAAAACACTTGAGGCAGGGAGATAGCTTAGTTGGTA 0.4 13 -49.019 -310.6 -0.843 42.14 -1.009 +candidate_22169998 chr16 9169681 9169721 AAAACAAACCCTACCTTAATGGGAGATATCACAGACTGGG 0.425 1 -48.556 -308.4 -0.838 42.0 -1.839 +candidate_21761043 chr16 9183788 9183828 AAAACAAAACAAGACAAGACAAGACAGGACAGGACAGGAC 0.425 1094 -50.067 -315.4 -0.855 42.81 998.226 +candidate_21951872 chr16 10129152 10129192 AAAACAAAATCTCATGCAACCAAGTCAGGCCTCCAGCTGG 0.475 2 -52.718 -317.4 -0.853 46.06 -0.606 +candidate_22432810 chr16 10143517 10143557 AAAACAAATGTTATCAGTCTGAAGGATAACATCCCTTTCC 0.35 8 -46.285 -308.3 -0.845 38.82 -3.924 +candidate_22138543 chr16 10153026 10153066 AAAACAAACAGTATGATGGTCTAAGTTGGGCCATAGACAC 0.4 5 -48.528 -312.0 -0.849 41.3 -2.501 +candidate_22214644 chr16 10161150 10161190 AAAACAAAGAAAATAATAATTCTGTGTCCTTGCCAGGGGC 0.375 2 -48.338 -311.5 -0.848 41.04 -2.705 +candidate_22299683 chr16 10168337 10168377 AAAACAAAGGCCTAATCCATCAAAGTTCATAGTTCTGGGA 0.375 387 -47.932 -307.9 -0.838 41.08 0.274 +candidate_22322429 chr16 10191280 10191320 AAAACAAAGTCTCTGCTGGGCTTTCTTGAAATTTCCTTTA 0.35 519 -47.889 -310.4 -0.846 40.54 -0.821 +candidate_21654043 chr16 11114621 11114661 AAAACAAAACAAAACAAAACACTGCCCTCATCTCAAGTCC 0.375 71 -49.122 -315.2 -0.858 41.45 0.941 +candidate_21686495 chr16 11114626 11114666 AAAACAAAACAAAACACTGCCCTCATCTCAAGTCCCCAAA 0.4 4 -50.251 -312.7 -0.846 43.38 0.941 +candidate_21780635 chr16 11114631 11114671 AAAACAAAACACTGCCCTCATCTCAAGTCCCCAAACAACT 0.425 0 -50.961 -313.1 -0.845 44.33 0.874 +candidate_22171219 chr16 11135198 11135238 AAAACAAACCCTTCCCTCCCCAAGTAGCTTTTGTTCATGT 0.425 1027 -50.539 -310.6 -0.839 44.2 -0.998 +candidate_22431606 chr16 11140939 11140979 AAAACAAATGTGGTGCACATCTTTACTCCAAGTACTCCGG 0.425 24 -50.239 -316.1 -0.857 42.92 -1.901 +candidate_21738820 chr16 11141085 11141125 AAAACAAAACAAAGGCTAGAGAGATGGCTCAGCAGTTAAG 0.4 1201 -49.06 -314.3 -0.855 41.61 -0.981 +candidate_22300372 chr16 11141090 11141130 AAAACAAAGGCTAGAGAGATGGCTCAGCAGTTAAGAGCAC 0.45 1237 -50.85 -316.4 -0.856 43.74 -2.472 +candidate_21793507 chr16 11160012 11160052 AAAACAAAACAGTGCCAGTGCACTGGTGCACGACTTTAGT 0.45 0 -53.13 -321.1 -0.864 45.85 -5.818 +candidate_22162200 chr16 11163816 11163856 AAAACAAACCAGGGTCTCAAATAGCCCAGCTTGGCTATGA 0.45 3 -51.44 -312.4 -0.841 45.16 -3.838 +candidate_22168537 chr16 11170884 11170924 AAAACAAACCCCATCCCACCTCAGCTTCATTACTGCACTT 0.45 0 -51.692 -312.9 -0.842 45.4 -0.026 +candidate_22197324 chr16 11181750 11181790 AAAACAAACTCTTCCTCCCATTCTACTAAGGACTGCTAGG 0.425 0 -48.492 -309.7 -0.842 41.71 -0.299 +candidate_22072895 chr16 11187568 11187608 AAAACAAACAAACAAAGATGAGCCTTTGAAGCCCTAGAAC 0.375 2 -48.698 -314.0 -0.855 41.1 -2.775 +candidate_21904608 chr16 11192920 11192960 AAAACAAAAGTAGTCAGGTGAGATGTGAAATACCAACAGT 0.35 0 -47.196 -309.8 -0.847 39.75 -0.359 +candidate_21890879 chr16 12137774 12137814 AAAACAAAAGGAAGAAGATTGATAGTGAGAGAGGAGTCTG 0.375 0 -46.741 -309.5 -0.847 39.32 -0.538 +candidate_22305276 chr16 12138525 12138565 AAAACAAAGGGTACACAAAGTAAATTGTGTGTGTGTGTGT 0.35 40 -48.408 -313.4 -0.854 40.73 -3.998 +candidate_22455527 chr16 12145387 12145427 AAAACAAATTGTGTCAGAGTATCTGGCTAAGGGGTTCTGC 0.425 0 -49.831 -313.8 -0.851 42.77 -2.478 +candidate_22548235 chr16 12159703 12159743 AAAACAACACAATGAGACAGAGAAGCCTGGATTTTAACAA 0.35 1 -47.821 -311.2 -0.849 40.33 -0.509 +candidate_22548621 chr16 12161010 12161050 AAAACAACACACAACTCCACAATACAAGAACTACACTAGA 0.35 0 -47.124 -311.0 -0.851 39.48 -0.246 +candidate_22526849 chr16 12172836 12172876 AAAACAACAACAGACACACACAGCTGTGGTAGGGTAGCCA 0.475 0 -52.852 -317.1 -0.852 46.28 -2.538 +candidate_22540553 chr16 12181858 12181898 AAAACAACAATAGTATGCTCTAACCAACCCATGACTTCCC 0.4 0 -48.458 -311.0 -0.847 41.37 -0.076 +candidate_22080165 chr16 12188710 12188750 AAAACAAACAAACACAAAGCCTATCCATCCCCATGGGTCT 0.425 2 -50.601 -310.6 -0.838 44.28 -1.462 +candidate_22129434 chr16 12190394 12190434 AAAACAAACAGAAGGAAAAGAGCCAAGCGAAGGCATAAGA 0.4 68 -50.256 -315.0 -0.854 43.01 -1.859 +candidate_22391255 chr16 13108590 13108630 AAAACAAATCCACTTGCAGCGGCTGATGTGAAGGGAGATT 0.45 0 -52.435 -316.9 -0.853 45.68 -0.576 +candidate_22134530 chr16 13118550 13118590 AAAACAAACAGCTAGAAGTCAGATTGGGGATCCAAGCTGG 0.45 52 -50.762 -313.8 -0.848 44.06 -4.723 +candidate_22302865 chr16 13127182 13127222 AAAACAAAGGGAGGGAGGAGGGGAGCGGAGAGGAGGGGAG 0.625 1043 -56.248 -314.2 -0.832 51.89 998.226 +candidate_22451921 chr16 13142802 13142842 AAAACAAATTGAGGCAGGGAGCCACCGAATGACTTATTCC 0.45 0 -51.321 -315.6 -0.852 44.47 -3.461 +candidate_22431610 chr16 13150836 13150876 AAAACAAATGTGGTGGCCATCAGCCCTGTCCTCAGTAGTC 0.5 0 -52.935 -316.5 -0.85 46.59 -2.179 +candidate_22281771 chr16 13160190 13160230 AAAACAAAGCGAACAGAAATGTGCAGGTACTTTTGCGGCG 0.45 0 -53.506 -326.5 -0.88 45.43 -1.955 +candidate_22307094 chr16 13176077 13176117 AAAACAAAGGTATGATCACACTATCCCAAGAAGGTTTTCT 0.35 0 -46.777 -306.9 -0.839 39.66 -0.665 +candidate_22190073 chr16 13184132 13184172 AAAACAAACTAGGTGGGAAAGAGTTTACTTTGAGTGGTAG 0.375 2 -47.217 -310.1 -0.848 39.83 -1.135 +candidate_22009936 chr16 13198354 13198394 AAAACAAACAAAACGGGCCAAGCAGAAACCTATCTGTAGC 0.425 0 -51.023 -318.0 -0.861 43.6 -1.372 +candidate_21842776 chr16 14112129 14112169 AAAACAAAACTCCAAACCCAAACAACCAAAGCACCAAAGG 0.4 64 -50.532 -315.4 -0.854 43.3 0.761 +candidate_21685155 chr16 14129896 14129936 AAAACAAAACAAAACACCATGAGGCCTTAGGCATGGGTTC 0.425 2 -50.907 -315.0 -0.851 43.94 -2.985 +candidate_21777113 chr16 14129901 14129941 AAAACAAAACACCATGAGGCCTTAGGCATGGGTTCACTGG 0.475 0 -52.438 -315.6 -0.848 46.01 -2.985 +candidate_22483304 chr16 14130104 14130144 AAAACAACAAAATCCCCACAAAGCACTCTAGGGTGATGGT 0.425 1 -50.64 -311.6 -0.841 44.16 -1.722 +candidate_22411499 chr16 14145787 14145827 AAAACAAATGAGATAAGAGAGAGGCTCAAAAGGCTGCAGT 0.4 0 -49.441 -312.2 -0.847 42.43 -2.314 +candidate_21795805 chr16 14150563 14150603 AAAACAAAACATACAATCTAAGTGAGTCCAAGTCTCTGAC 0.35 0 -46.432 -311.3 -0.854 38.57 0.011 +candidate_21872220 chr16 14180132 14180172 AAAACAAAAGAGGATAGTGGAAGAGTGTAGGGGACAGAAA 0.4 1 -48.273 -307.9 -0.837 41.62 0.144 +candidate_21851787 chr16 14185388 14185428 AAAACAAAACTTGGTTATGTGTTCCAGACAGAAGAGAACT 0.35 0 -47.448 -310.3 -0.848 39.99 -1.676 +candidate_22369611 chr16 14186124 14186164 AAAACAAATAGTTTGCCCTGGTAAGAACCTGGTGTGGGTC 0.45 0 -50.927 -313.5 -0.847 44.32 -4.359 +candidate_22409580 chr16 15123716 15123756 AAAACAAATGACAGTTCATGTTGGCAATCATAGAGGATAG 0.35 13 -46.769 -310.8 -0.851 39.06 -0.962 +candidate_22344144 chr16 15131264 15131304 AAAACAAATAAATAAAACCAACTCCTGAATCCCCTTCCTG 0.35 0 -46.571 -307.5 -0.841 39.3 0.101 +candidate_22077881 chr16 15134201 15134241 AAAACAAACAAACAAGACCTAAAACTGTCCTGTAACAGTG 0.35 4 -47.377 -313.3 -0.857 39.46 -2.535 +candidate_22489854 chr16 15135210 15135250 AAAACAACAAAGAGGGCATATTCTGAGGAGATTTGGGAAT 0.375 0 -48.073 -307.7 -0.837 41.29 0.078 +candidate_22289175 chr16 15136403 15136443 AAAACAAAGGAAACCTGAAGTGTCCCTAGACATGACCTAA 0.4 0 -48.584 -308.8 -0.839 41.87 -1.447 +candidate_22563325 chr16 15143614 15143654 AAAACAACAGAAAGCCCACATACACGAGGAAACTGAACAA 0.4 1517 -50.229 -315.5 -0.855 42.9 -0.736 +candidate_21696985 chr16 15154698 15154738 AAAACAAAACAAAACCGTGTTGTAGATGTTCCTGGAGAAA 0.35 0 -48.294 -313.1 -0.854 40.64 -1.44 +candidate_21826337 chr16 15154703 15154743 AAAACAAAACCGTGTTGTAGATGTTCCTGGAGAAAGAAAT 0.35 0 -47.841 -311.5 -0.85 40.31 -0.922 +candidate_22494369 chr16 15155435 15155475 AAAACAACAAATTCTGCCATGCTTAGGGTTACAAATTGCT 0.35 29 -48.597 -312.1 -0.85 41.17 0.344 +candidate_22277296 chr16 15184133 15184173 AAAACAAAGCCACTCCTAGGCTCCTTGCTATTTGTAGGAC 0.45 0 -50.5 -313.6 -0.848 43.75 -2.282 +candidate_22305091 chr16 15186089 15186129 AAAACAAAGGGGTGGGAAACCCATCTCCCACCAGAGCTCG 0.55 9 -54.771 -316.6 -0.844 49.16 -6.341 +candidate_21756048 chr16 16119405 16119445 AAAACAAAACAACCCAACCATGAACATAGACTCAGACCCT 0.4 2 -49.347 -310.4 -0.842 42.6 0.124 +candidate_22445629 chr16 16131714 16131754 AAAACAAATTCACACATTGTCTTTCCACGAATCCAGCCCT 0.4 1055 -50.331 -314.3 -0.851 43.22 -0.512 +candidate_21779002 chr16 16185138 16185178 AAAACAAAACACCTTCCTCTCAACACCTCATGGTACCTTC 0.425 1380 -49.676 -312.9 -0.849 42.72 -1.209 +candidate_22169694 chr16 16192234 16192274 AAAACAAACCCGGTATGCCCCATAGTTAAAGCATTCCTGG 0.45 254 -51.072 -313.8 -0.847 44.45 -2.341 +candidate_21959123 chr16 17100947 17100987 AAAACAAAATGAGTGTGTCTAACACTAGTAGAAAGCCCCA 0.375 0 -48.037 -310.3 -0.846 40.84 -3.425 +candidate_22111133 chr16 17108267 17108307 AAAACAAACAAGGAGCTGGAGAAATAGCTCAGAGGTTAAG 0.4 1058 -48.51 -312.2 -0.85 41.25 -3.145 +candidate_21863612 chr16 17180243 17180283 AAAACAAAAGAAGTGAAGGCAGATCTTTGTGAGTTGAAGG 0.375 3 -48.405 -313.8 -0.856 40.77 -1.526 +candidate_21856056 chr16 17181427 17181467 AAAACAAAAGAAAACACAGAAGTAGCCCATCTCTTTGAGA 0.35 3 -47.479 -310.3 -0.847 40.03 -0.462 +candidate_21909049 chr16 17189854 17189894 AAAACAAAAGTGGTGAGGAAAGATGGCTCAACAGTTAAAA 0.35 123 -48.031 -311.1 -0.848 40.61 -3.688 +candidate_22107943 chr16 17193782 17193822 AAAACAAACAAGCAAACAAAACAACAACATCAGCACTGGC 0.375 491 -50.532 -320.3 -0.87 42.42 -0.059 +candidate_22528622 chr16 17193799 17193839 AAAACAACAACATCAGCACTGGCTGCTCTTCCAGGGGACC 0.525 97 -54.549 -319.2 -0.853 48.3 -3.511 +candidate_21872058 chr16 17195497 17195537 AAAACAAAAGAGGAAGAAAGGAAGCCAGCAAGCAAGTCAG 0.425 488 -50.719 -316.3 -0.856 43.49 -0.226 +candidate_21875152 chr16 18106130 18106170 AAAACAAAAGATGGAGGAGGAGGAGGAGGAGGAGGAGGAG 0.525 5371 -51.803 -309.6 -0.831 46.43 -0.036 +candidate_21814624 chr16 18106422 18106462 AAAACAAAACCAGAAAGAAGCCACATAGAATGTTGGGCAT 0.375 0 -49.213 -311.6 -0.846 42.13 -2.204 +candidate_21968283 chr16 18109528 18109568 AAAACAAAATGTTCCTCTGGTTTTCCAACAGGCTGTGGGG 0.45 0 -51.638 -314.8 -0.848 45.01 -2.017 +candidate_22274021 chr16 18122906 18122946 AAAACAAAGCATATTTGCACTCCCTGTGGGTGGCAGTGGC 0.5 0 -54.205 -319.6 -0.856 47.68 -2.631 +candidate_22240291 chr16 18162248 18162288 AAAACAAAGACTACTTACATCCAGCCCCTCTGGAGCTCTG 0.475 0 -51.02 -313.5 -0.846 44.54 -3.637 +candidate_22196342 chr16 18179921 18179961 AAAACAAACTCTATGATCTGCCTGGTTACCCTGGCCAAGC 0.475 0 -51.938 -315.1 -0.848 45.45 -3.537 +candidate_22274960 chr16 18191168 18191208 AAAACAAAGCATGTTATGAAATCCCAGAGAAGCCCATGGC 0.425 0 -50.586 -314.4 -0.851 43.63 -2.694 +candidate_22309502 chr16 18197471 18197511 AAAACAAAGGTTCCTCCTTTCAGATCCCCACAGGGTCTCC 0.5 0 -52.018 -311.8 -0.838 46.22 -4.334 +candidate_22325033 chr16 18199206 18199246 AAAACAAAGTGATGCTGAGGGCCCATGAGGAGGCTACAGT 0.5 0 -53.316 -314.4 -0.842 47.46 -2.29 +candidate_21894666 chr16 19131189 19131229 AAAACAAAAGGATATACCTTCTTCTCAGCACCTCATCCTA 0.375 1029 -47.097 -306.6 -0.837 40.21 -2.042 +candidate_21983199 chr16 19155514 19155554 AAAACAAAATTTGGGTGGGAGGTGGGAAAGTTCTGGGAGA 0.45 0 -51.259 -309.8 -0.834 45.37 -0.236 +candidate_22357832 chr16 20117628 20117668 AAAACAAATACACAGTGTGCTTGTGGGATTAAAATGTCCC 0.375 0 -48.549 -313.2 -0.853 41.04 -1.674 +candidate_21792153 chr16 20134652 20134692 AAAACAAAACAGGTCCTTAGAGGCAAGAACTACTGTAGAG 0.4 5 -48.028 -311.5 -0.849 40.74 -0.582 +candidate_22487831 chr16 20136212 20136252 AAAACAACAAACCACTAAGGAAATTAGTGTTAGGGGTTCT 0.35 1 -46.984 -307.2 -0.839 39.87 -3.316 +candidate_21712832 chr16 20146964 20147004 AAAACAAAACAAAATTGTAAGTTGGAGGCAAGAGCTGTGT 0.35 1 -48.718 -313.4 -0.853 41.12 -1.515 +candidate_21979257 chr16 20146969 20147009 AAAACAAAATTGTAAGTTGGAGGCAAGAGCTGTGTTGTAA 0.35 1 -48.297 -312.7 -0.853 40.7 -1.515 +candidate_22206827 chr16 20161423 20161463 AAAACAAACTTGAAGGGAATTAAGTAGGCATGGAGGTTTT 0.35 0 -47.467 -307.9 -0.84 40.38 -0.516 +candidate_21882598 chr16 20162935 20162975 AAAACAAAAGCATAAAACCTCAGTCCTGTCATAGCCCATA 0.375 0 -48.199 -309.5 -0.842 41.17 0.334 +candidate_22249903 chr16 20170601 20170641 AAAACAAAGAGTGTAATGAACCTCCATGTGCCAAATCAAT 0.35 0 -47.951 -310.4 -0.846 40.62 -0.709 +candidate_21911224 chr16 21183507 21183547 AAAACAAAAGTTGGTACCAGAAGTAGAGTATTGCTGTGAT 0.35 617 -47.082 -309.5 -0.846 39.65 -0.236 +candidate_21658299 chr16 22131287 22131327 AAAACAAAACAAAACAAAACCCCAGCCAACCAAGCCTCAC 0.425 383 -51.75 -317.3 -0.856 44.64 0.584 +candidate_21696099 chr16 22131292 22131332 AAAACAAAACAAAACCCCAGCCAACCAAGCCTCACAGCCC 0.5 11 -54.428 -318.8 -0.852 48.11 0.284 +candidate_21822694 chr16 22131297 22131337 AAAACAAAACCCCAGCCAACCAAGCCTCACAGCCCTCTTT 0.5 0 -54.33 -315.6 -0.842 48.56 0.284 +candidate_22554080 chr16 22145308 22145348 AAAACAACACCAAGGTCATGGAAGGCAGCTGGTGACATCA 0.475 0 -53.1 -316.2 -0.848 46.76 -2.925 +candidate_21909100 chr16 22147477 22147517 AAAACAAAAGTGTAAAGTGCTTGCCAGACACAGAGACTCA 0.4 0 -50.074 -315.5 -0.856 42.7 -1.202 +candidate_21792914 chr16 22154266 22154306 AAAACAAAACAGTATAAGTAGCAGCCAAACAAAACCACCA 0.35 3 -48.255 -312.1 -0.851 40.74 0.834 +candidate_21858474 chr16 22172199 22172239 AAAACAAAAGAAACTGGAGGATGATGGAGCAATGCCTTTA 0.375 2 -48.764 -310.5 -0.844 41.73 0.141 +candidate_21815808 chr16 22192173 22192213 AAAACAAAACCAGGACAGTGTGTTACCTCCAAACATTAGC 0.4 1 -49.37 -314.3 -0.854 42.01 -0.384 +candidate_22121522 chr16 23101375 23101415 AAAACAAACACATACAAACAACCAGTACAGTAGTGCCAGA 0.375 1 -48.728 -313.1 -0.852 41.28 -0.486 +candidate_21696680 chr16 23161159 23161199 AAAACAAAACAAAACCCTGATCTTGAAAGCCAAGAGGTGA 0.375 4 -49.127 -311.7 -0.847 42.01 -2.403 +candidate_21824874 chr16 23161164 23161204 AAAACAAAACCCTGATCTTGAAAGCCAAGAGGTGATTGGA 0.4 0 -49.661 -310.9 -0.842 42.92 -3.011 +candidate_22528041 chr16 23191959 23191999 AAAACAACAACAGTACATTCCCTGCCGTGGCCGATGAACT 0.475 2 -53.508 -319.4 -0.857 46.72 -0.496 +candidate_22198662 chr16 24108652 24108692 AAAACAAACTGACAAACAGAAAACAAAAGAGCACTCCTTG 0.35 26 -48.182 -315.5 -0.862 40.13 -1.989 +candidate_21871569 chr16 24108671 24108711 AAAACAAAAGAGCACTCCTTGCTCAGGTATTTACCTGTTG 0.4 0 -49.132 -314.0 -0.854 41.75 -5.143 +candidate_21839431 chr16 24135799 24135839 AAAACAAAACTAGAGGTTCACTGGGAGGACTAGCCAAGCT 0.45 0 -50.795 -311.6 -0.841 44.46 -0.895 +candidate_21925638 chr16 24143294 24143334 AAAACAAAATAAGATGGTGGTTTGCCTTAATGACAGGAAG 0.35 0 -47.19 -310.6 -0.849 39.62 -0.439 +candidate_22298648 chr16 24187087 24187127 AAAACAAAGGCATCCTGGCCTGTTAGAAACTAAGTTTCAG 0.4 0 -49.062 -313.0 -0.851 41.82 -4.897 +candidate_22082778 chr16 25112695 25112735 AAAACAAACAAACAGTCGAACAAACAAACCCCAATCATAC 0.35 1066 -48.251 -315.6 -0.862 40.2 0.424 +candidate_21892971 chr16 25169626 25169666 AAAACAAAAGGAGGAGGAAGAGAATTAAGAAATTGACAGG 0.35 7 -46.34 -308.2 -0.844 38.91 -0.622 +candidate_22274607 chr16 25188474 25188514 AAAACAAAGCATGATGTGTATGTGTGTGTGTGTGTGTGTG 0.4 1445 -50.449 -320.0 -0.869 42.47 -0.523 +candidate_22298997 chr16 26100961 26101001 AAAACAAAGGCCAAATCTCACAAAGCACCAAGTCAAGAAT 0.375 0 -49.535 -313.1 -0.85 42.3 0.394 +candidate_22089455 chr16 26154863 26154903 AAAACAAACAAAGACACAGACAAACAGACAGAGAGACTGA 0.375 1265 -48.584 -313.7 -0.855 41.01 -1.989 +candidate_22331015 chr16 26162478 26162518 AAAACAAAGTTCCAAGGGGCCAATCCCTAGGCCAAAAGCA 0.475 0 -52.987 -312.8 -0.838 47.21 -3.572 +candidate_22547933 chr16 27108597 27108637 AAAACAACACAAGTGGGGAGGGAGGGAGGGATTTGGGAGG 0.55 692 -54.031 -312.2 -0.832 49.0 -0.136 +candidate_21834785 chr16 27141570 27141610 AAAACAAAACGTATGAACCCAGAATGAGTAGACAACAGGA 0.375 25 -48.304 -311.9 -0.85 40.93 -0.126 +candidate_22159085 chr16 27143471 27143511 AAAACAAACCACAGCAGAAAATAGAAGGGATGAAAAGAAG 0.35 8 -47.2 -311.2 -0.851 39.55 0.494 +candidate_21753987 chr16 27162495 27162535 AAAACAAAACAACAGAAAGCTCACATACACGTGGAAGCCG 0.425 1097 -51.542 -321.9 -0.872 43.63 -0.454 +candidate_22192227 chr16 27164290 27164330 AAAACAAACTCAAACAAATCAGTAGCCTTCCTCTACTCAA 0.35 1220 -47.196 -309.8 -0.847 39.75 -1.005 +candidate_22102208 chr16 28116722 28116762 AAAACAAACAACATACACTTGATATTGTCAAGCAAGGCCG 0.375 0 -49.123 -317.0 -0.864 41.18 -2.885 +candidate_22486781 chr16 28140215 28140255 AAAACAACAAACAATCAAAGCCCATCCCTCAACCAACCAA 0.4 13 -50.523 -312.6 -0.845 43.75 1.984 +candidate_21945865 chr16 28149023 28149063 AAAACAAAATCAGGGGTGCTTTAATATCATGGTTGCAATC 0.35 0 -47.586 -311.4 -0.851 40.0 0.308 +candidate_21939090 chr16 28155420 28155460 AAAACAAAATATGCTCAGTGCAAACCTCAAGGGCAGGTCA 0.425 0 -51.29 -314.7 -0.849 44.48 -2.154 +candidate_21955055 chr16 28167909 28167949 AAAACAAAATGAAACAAAACTCCGGTATCTTTCCTGTCTC 0.35 4 -47.319 -312.9 -0.856 39.44 0.434 +candidate_21858525 chr16 29165094 29165134 AAAACAAAAGAAACTTTCAATGCAAGCCAGATGACCTGAT 0.35 0 -48.441 -312.1 -0.85 40.97 -1.335 +candidate_21885172 chr16 29179333 29179373 AAAACAAAAGCCCACCTAGACCATCATCTACCATTTGTGT 0.4 0 -49.264 -310.1 -0.841 42.54 -0.315 +candidate_22156764 chr16 29182366 29182406 AAAACAAACCAACTCATCCTAACACAGGGTTTCCCCTTTT 0.4 254 -49.487 -309.3 -0.838 42.95 -2.292 +candidate_22139245 chr16 30109118 30109158 AAAACAAACAGTGTGCTTTGCAAGGATGCAGTCATACTTG 0.4 0 -50.375 -318.5 -0.864 42.61 -4.005 +candidate_22553460 chr16 30124149 30124189 AAAACAACACATTTCAGGCTGTGTCTTGCCCAGAGTGACT 0.45 3 -52.152 -316.4 -0.852 45.4 -1.895 +candidate_22083540 chr16 30140025 30140065 AAAACAAACAAACATGGCCAAGTCTATCGTAGAAAATGCC 0.375 0 -48.909 -315.7 -0.86 41.11 -0.156 +candidate_21755149 chr16 30168215 30168255 AAAACAAAACAACCAAACAACAAGGTGTCTCTTTGCCCTA 0.375 5 -49.435 -313.0 -0.85 42.19 -0.619 +candidate_21838416 chr16 31102444 31102484 AAAACAAAACTACACAACACGGAAGATATTCTCTGTAGTG 0.35 1 -46.726 -313.3 -0.859 38.65 -2.577 +candidate_22294429 chr16 31104483 31104523 AAAACAAAGGAGCTAATTAAGCCAATGAGCAGCCTCCTCT 0.425 0 -50.382 -311.9 -0.843 43.78 -2.778 +candidate_22291090 chr16 31132942 31132982 AAAACAAAGGAAGGAAGAAAGGAAAGAAAGGAGCGAGGGA 0.425 1237 -50.223 -311.4 -0.842 43.66 998.226 +candidate_22244542 chr16 31144986 31145026 AAAACAAAGAGAGAGGTGCAAGAGGGAGTGGGGAGGGGTC 0.55 5 -53.922 -314.2 -0.839 48.49 1.214 +candidate_22200957 chr16 31174384 31174424 AAAACAAACTGGACAGGCAGTGACAGACTCCCAGAGCTGA 0.5 0 -53.369 -316.5 -0.848 47.15 -2.89 +candidate_22300972 chr16 31194128 31194168 AAAACAAAGGCTGCTTGACCACAGGCACTACAATACTACC 0.45 0 -51.191 -316.4 -0.855 44.18 -1.695 +candidate_21666318 chr16 31196747 31196787 AAAACAAAACAAAACAAACAAAAGTATCACCCTATCGCCC 0.35 50 -48.067 -314.3 -0.858 40.17 1.134 +candidate_21717478 chr16 31196752 31196792 AAAACAAAACAAACAAAAGTATCACCCTATCGCCCTAGGT 0.375 1 -48.499 -310.7 -0.845 41.36 -0.442 +candidate_22012273 chr16 31196757 31196797 AAAACAAACAAAAGTATCACCCTATCGCCCTAGGTAGCCT 0.425 0 -49.771 -310.7 -0.841 43.19 -0.442 +candidate_22214148 chr16 32110929 32110969 AAAACAAAGAAAAGCAGAATGCAGGCCAAGCGGTGGCACT 0.475 0 -54.526 -321.1 -0.859 47.73 -5.901 +candidate_22080497 chr16 32111082 32111122 AAAACAAACAAACACACACCAACCAGAAGCAGAATGTTTA 0.35 21 -48.722 -313.9 -0.855 41.05 -0.705 +candidate_22240135 chr16 32114579 32114619 AAAACAAAGACTAACCATCACATACGACCTGGATACCCTA 0.4 0 -48.202 -309.1 -0.841 41.34 -0.649 +candidate_22306792 chr16 32126901 32126941 AAAACAAAGGTAGCCTGCTCACCAACATTGGAAAATCGAG 0.425 0 -50.691 -316.8 -0.858 43.38 -2.508 +candidate_22519521 chr16 32145524 32145564 AAAACAACAACAACAACAACAGAAAGAAACTGGGCATGGT 0.375 283 -49.956 -314.7 -0.854 42.58 -0.509 +candidate_21852077 chr16 32162767 32162807 AAAACAAAACTTTAAAAGGGTGGGAGGCAGAAGAGAACCC 0.425 0 -49.985 -312.0 -0.845 43.26 -1.225 +candidate_21920282 chr16 32187546 32187586 AAAACAAAATAAACAGAAAAGCAAGCATTCCACAAAGCCC 0.35 8 -48.636 -314.9 -0.859 40.79 0.384 +candidate_22153094 chr16 32194021 32194061 AAAACAAACCAAACAAAAGGCAGCACTGGTTGCTCTTCCA 0.425 25 -52.132 -317.0 -0.854 45.17 -2.102 +candidate_21696763 chr16 33141995 33142035 AAAACAAAACAAAACCCTGTTGGTTTTCCGACTTAGCAGG 0.4 1 -50.129 -316.3 -0.858 42.65 -3.598 +candidate_21825189 chr16 33142000 33142040 AAAACAAAACCCTGTTGGTTTTCCGACTTAGCAGGAGTCA 0.425 23 -50.941 -314.6 -0.85 44.05 -5.103 +candidate_22334282 chr16 33149008 33149048 AAAACAAAGTTTGCCACTCTTGGCATATCTAAGACTTTAG 0.35 0 -46.873 -311.4 -0.853 39.11 -3.711 +candidate_21883970 chr16 33164535 33164575 AAAACAAAAGCCAACCTAAGGGTTGGAGAGATGGTCCAGT 0.45 54 -51.111 -310.8 -0.837 45.01 -5.968 +candidate_22374476 chr16 33181585 33181625 AAAACAAATATCTAGCTGGGCCTGGTGATGCAGGCTGTAA 0.45 10 -51.426 -313.1 -0.844 45.03 -4.355 +candidate_21758248 chr16 33187988 33188028 AAAACAAAACAACTCGTGGTCTCCTTTTCTTGGCTTCTCC 0.425 1 -50.598 -316.8 -0.858 43.26 0.164 +candidate_22307991 chr16 34107515 34107555 AAAACAAAGGTCTTCTCGGTGTATATCCTGTCCTTTTGGA 0.4 0 -48.737 -310.1 -0.843 41.86 -1.026 +candidate_22155674 chr16 34122313 34122353 AAAACAAACCAACAATCGTAACTAGGAGGGAAAACGGCAG 0.425 0 -50.571 -317.3 -0.86 43.15 -0.309 +candidate_22482990 chr16 34149365 34149405 AAAACAACAAAATATCATTGTCACCTCCTGCTCTAGATGT 0.35 0 -47.116 -309.1 -0.845 39.75 -0.512 +candidate_22231264 chr16 35100492 35100532 AAAACAAAGAATGAATGAATTCAGGCATGGTGATTCACCC 0.375 3 -48.555 -312.4 -0.851 41.17 -2.827 +candidate_22523023 chr16 35115313 35115353 AAAACAACAACAACCAAACCTACAAGAACAACAAAGGCAT 0.35 1072 -48.79 -313.1 -0.852 41.26 0.011 +candidate_21877901 chr16 35139947 35139987 AAAACAAAAGCAAAAGCAAAGCACGATGCTAATGTGAGAA 0.35 1 -49.52 -317.8 -0.865 41.45 -2.156 +candidate_22366619 chr16 36101464 36101504 AAAACAAATAGCCCCAAGAAGGAATGTGCAAAAGGCCTGA 0.425 0 -51.151 -312.7 -0.843 44.64 -1.312 +candidate_21759100 chr16 36139573 36139613 AAAACAAAACAAGAAAACCCCATGCTTCAGATAGCTAGGC 0.4 4 -49.428 -313.8 -0.852 42.16 -0.629 +candidate_21806808 chr16 36186937 36186977 AAAACAAAACCAAACAAAACCAACAGAAATCCACTGGGTC 0.375 147 -49.125 -313.9 -0.854 41.66 -0.509 +candidate_22560242 chr16 37102570 37102610 AAAACAACACTGGGGAAAAGAGTCTCATTATTATACTCTG 0.35 1 -45.875 -308.2 -0.846 38.32 -1.825 +candidate_21966751 chr16 37129884 37129924 AAAACAAAATGTCCGTGCTATTCTCATGTCTGTCAGTGGC 0.425 0 -50.716 -318.5 -0.863 43.14 0.331 +candidate_22270008 chr16 37196041 37196081 AAAACAAAGCACCCATATCATAAATCATTCTCTGGATCAC 0.35 0 -46.586 -309.5 -0.848 39.02 0.191 +candidate_22520899 chr16 38131343 38131383 AAAACAACAACAACAACCAGTCCAGTGCAGAGACCAAAAC 0.425 2 -51.168 -318.3 -0.861 43.74 0.191 +candidate_22462363 chr16 38165907 38165947 AAAACAAATTTGAGGTGAATCCTGTTTTACAGTAGCAGCA 0.35 0 -48.017 -311.8 -0.85 40.48 -1.782 +candidate_22542201 chr16 38187412 38187452 AAAACAACAATCTAGCCAGCTGGCCTGAGAAAAGTGGGTG 0.475 0 -52.404 -316.9 -0.853 45.74 -2.149 +candidate_21829358 chr16 38192572 38192612 AAAACAAAACCTGGCTAATTTAGTACAGTGCTTTGTCCTC 0.375 0 -48.132 -313.0 -0.854 40.55 -0.626 +candidate_22254279 chr16 39105899 39105939 AAAACAAAGATGAAGAAACACCCAGATCCAACTGGGGCCT 0.45 0 -51.425 -311.3 -0.838 45.33 -4.591 +candidate_21808347 chr16 39121119 39121159 AAAACAAAACCAAACTTCCAGCTGTTCAAGTCGTCTTGTG 0.4 1 -50.31 -318.9 -0.866 42.47 -1.632 +candidate_22199459 chr16 39138516 39138556 AAAACAAACTGATACTTGTCCACACAGTCTCTGATAGTAC 0.375 0 -47.032 -311.9 -0.854 39.33 -0.928 +candidate_22349836 chr16 39185937 39185977 AAAACAAATAACTGAGCAGAGAGGAAGCCCACGGAGTGAG 0.475 6 -51.805 -317.2 -0.856 44.93 -2.955 +candidate_22409934 chr16 39186056 39186096 AAAACAAATGACCCAATTAACAAATGGGCTATGGAGCTGA 0.375 1084 -48.754 -309.9 -0.842 41.82 -2.292 +candidate_22308782 chr16 39186247 39186287 AAAACAAAGGTGGTAAATGCTGGTGAAGGTGTGGCTAAAC 0.425 1 -50.663 -315.5 -0.854 43.55 0.364 +candidate_21881395 chr16 39190074 39190114 AAAACAAAAGCACTCTAAGCAGCTTAGGGAGGAAAGGAGT 0.425 8 -50.151 -311.7 -0.843 43.52 -2.038 +candidate_21844822 chr16 40101009 40101049 AAAACAAAACTCTTGTGACAACACACATGAAGTATCCACA 0.35 0 -48.032 -312.9 -0.854 40.34 -1.638 +candidate_22488840 chr16 40123532 40123572 AAAACAACAAACTTCGCTTAGGTGTCCTAAGCAAATGATT 0.35 0 -48.277 -313.3 -0.855 40.58 -5.131 +candidate_22383821 chr16 40125692 40125732 AAAACAAATCAAGCAGAAAGCCCATGCGGATAAGAGCGGT 0.45 0 -52.753 -318.8 -0.858 45.76 -1.007 +candidate_22193410 chr16 40142209 40142249 AAAACAAACTCACTATCAGAAATTGCCCAGCCTAGCCTAA 0.4 0 -49.219 -310.8 -0.843 42.37 0.527 +candidate_22207831 chr16 40187696 40187736 AAAACAAACTTGTCACTAGTCCAGTCCAGGGACTCAGACT 0.45 1 -50.499 -311.8 -0.843 44.05 -3.755 +candidate_22115072 chr16 41106475 41106515 AAAACAAACAATCTTAACTACTACCACTACCACCACCATC 0.375 37 -47.162 -310.2 -0.848 39.75 1.374 +candidate_22540990 chr16 41118273 41118313 AAAACAACAATATCAACTAACTGGACACCTCAGGGATTAA 0.35 299 -46.667 -307.1 -0.84 39.49 -0.906 +candidate_21982381 chr16 41132040 41132080 AAAACAAAATTTCTACCCACTACTCCCTGCAGTGACAGTT 0.4 0 -49.271 -311.1 -0.844 42.39 -1.282 +candidate_21822783 chr16 41170402 41170442 AAAACAAAACCCCATAGGTTTAAATAGCATTGTTGGGGTT 0.35 0 -47.697 -307.2 -0.837 40.79 -4.574 +candidate_22242847 chr16 41171621 41171661 AAAACAAAGAGAAATGTTCCTACCTGGTAACACATAGGAC 0.375 0 -47.134 -309.8 -0.847 39.77 -2.593 +candidate_22388274 chr16 41173653 41173693 AAAACAAATCATAACCAGCTTTTCACAGGTTCAGAAGCTC 0.375 0 -48.488 -314.1 -0.856 40.83 -1.825 +candidate_22423546 chr16 41192808 41192848 AAAACAAATGGCCCAATTTGTCATTGCTATACCTCATCAT 0.35 0 -47.83 -309.1 -0.842 40.66 -2.378 +candidate_22300595 chr16 42103309 42103349 AAAACAAAGGCTCACTTTCTATAGCACCAACACTTGGATT 0.375 1 -48.658 -311.2 -0.847 41.49 -3.561 +candidate_22530271 chr16 42145836 42145876 AAAACAACAACCATAAACTACCCTAGACATGGCTTTAAGT 0.35 0 -46.971 -307.9 -0.841 39.75 -0.732 +candidate_22213516 chr16 42184208 42184248 AAAACAAAGAAAACCTCCGAGTTTCTGTCTACCCAAAGAA 0.375 0 -48.455 -311.4 -0.848 41.2 -1.205 +candidate_21866061 chr16 42197679 42197719 AAAACAAAAGAATGGAGAGACTGCAAACATACTCCACTTT 0.35 0 -47.648 -310.5 -0.848 40.22 -2.238 +candidate_22140417 chr16 42198376 42198416 AAAACAAACATAACAATGCAATGGAATCCAGCTTTGCTTC 0.35 0 -48.457 -315.0 -0.859 40.55 -1.553 +candidate_21872626 chr16 43122088 43122128 AAAACAAAAGAGGTGAAAAGAAGTCTGCAGTCTAGCTGCC 0.425 0 -50.36 -316.5 -0.858 43.01 -3.062 +candidate_21700882 chr16 43126383 43126423 AAAACAAAACAAAACTGCTTAACACCTTGCCAGGCGCATG 0.425 0 -52.311 -321.8 -0.869 44.6 -0.789 +candidate_21847087 chr16 43126388 43126428 AAAACAAAACTGCTTAACACCTTGCCAGGCGCATGGATCC 0.475 1 -53.513 -320.8 -0.862 46.49 -3.397 +candidate_22193752 chr16 43152789 43152829 AAAACAAACTCAGCCAATGTTTGGAGGTTCCTCGTCTCAT 0.425 10 -50.872 -314.5 -0.85 43.98 -2.355 +candidate_22285544 chr16 43157945 43157985 AAAACAAAGCTGCCACAGCAATGTTAGTATCAGGAGACCT 0.425 0 -50.593 -313.6 -0.848 43.77 -3.829 +candidate_21875958 chr16 43193506 43193546 AAAACAAAAGATTGGGCTGCACTGTGTTCCTGTAAGTGGG 0.45 0 -51.663 -316.5 -0.854 44.76 -1.831 +candidate_22446077 chr16 44104803 44104843 AAAACAAATTCAGAGACTGACACGGTTCATGTCTGAGAAA 0.375 1 -48.698 -314.0 -0.855 41.1 -1.192 +candidate_21808115 chr16 44115256 44115296 AAAACAAAACCAAACCCTATACATAGCCAGATGGTATGAA 0.35 0 -46.825 -306.7 -0.838 39.75 -1.157 +candidate_22342579 chr16 44128322 44128362 AAAACAAATAAACCTATGAGCTGGAGCAAGTGGGGCCGGA 0.475 186 -52.685 -314.7 -0.845 46.48 -0.926 +candidate_22162118 chr16 44151172 44151212 AAAACAAACCAGGGAGTTGCTTCTGGGGTCCAGCTTTGAG 0.5 0 -53.231 -316.3 -0.848 47.01 -2.042 +candidate_22155947 chr16 44159950 44159990 AAAACAAACCAACATCCTGCTTTCACATTGAAGGGCAGAG 0.425 0 -50.853 -316.0 -0.855 43.71 -2.893 +candidate_21868751 chr16 44165904 44165944 AAAACAAAAGACCAGGTGACCAGCAATGTGATTAGAAAAG 0.375 0 -48.394 -313.2 -0.854 40.85 -0.806 +candidate_21875178 chr16 44178494 44178534 AAAACAAAAGATGGCATCCCGTGACAGGTACCAGTTCTAT 0.425 0 -50.268 -312.5 -0.845 43.54 -0.847 +candidate_22392409 chr16 45124376 45124416 AAAACAAATCCCACTTTGGTGGCACATATGTGTCATCTCA 0.4 3 -49.82 -312.3 -0.846 42.89 -2.747 +candidate_22170395 chr16 45154949 45154989 AAAACAAACCCTCCCTTCCTTAACTGAAGTTTCCTAGCTC 0.425 1 -49.151 -310.7 -0.843 42.4 -0.569 +candidate_22117822 chr16 45173818 45173858 AAAACAAACACAAATCTTTATCTACCTCCCTGAGCAGCCA 0.4 1 -49.333 -311.1 -0.844 42.47 0.484 +candidate_21748103 chr16 45181671 45181711 AAAACAAAACAACAACAAAACCCACACAATGGATGTGATG 0.35 26 -48.588 -315.1 -0.859 40.7 -3.192 +candidate_22501160 chr16 45181676 45181716 AAAACAACAACAAAACCCACACAATGGATGTGATGAGTTT 0.35 3 -48.655 -312.5 -0.851 41.18 -3.192 +candidate_22144385 chr16 46108727 46108767 AAAACAAACATCTGTGCTCAGGGGCTGCTGTAAGTGGTTC 0.475 0 -52.639 -318.5 -0.857 45.77 -0.829 +candidate_22266827 chr16 46140996 46141036 AAAACAAAGCAACTTGGGTAGGAAAAGGTGTGTTTGGCTA 0.4 302 -50.134 -312.8 -0.847 43.21 -1.928 +candidate_22297925 chr16 46186219 46186259 AAAACAAAGGCAGAGAGTCCAGATTTGCCTGGCCCAAAGA 0.475 0 -52.857 -314.5 -0.844 46.74 -3.135 +candidate_22285837 chr16 47151351 47151391 AAAACAAAGCTGGCAAACAATTTAGTTTGTAAAGTGGGTG 0.35 1 -48.298 -314.5 -0.858 40.43 -2.425 +candidate_21973007 chr16 47167787 47167827 AAAACAAAATTATAACACTGGGTCCTTATCCTGTGCTGCT 0.375 0 -48.337 -309.7 -0.843 41.31 -2.153 +candidate_22559472 chr16 47180265 47180305 AAAACAACACTGAGATTCCACCTCACAACAGTCAGAATGG 0.425 1361 -49.963 -314.8 -0.854 42.78 -0.882 +candidate_21704015 chr16 47181492 47181532 AAAACAAAACAAAAGAGGGCTCTGAGGTCAGTTGCTATGA 0.4 4 -49.655 -312.6 -0.848 42.64 -1.554 +candidate_21872467 chr16 47181497 47181537 AAAACAAAAGAGGGCTCTGAGGTCAGTTGCTATGAAAAGA 0.4 11 -49.344 -311.7 -0.846 42.38 -1.554 +candidate_22230471 chr16 48150618 48150658 AAAACAAAGAATATTACCAAGGACCACTCCACTCTGTCTC 0.4 0 -47.989 -310.5 -0.846 40.85 -0.919 +candidate_22097738 chr16 48156249 48156289 AAAACAAACAACAAAAGAGAGAGCTGAAAGGGACTGTACA 0.375 2 -48.641 -312.3 -0.85 41.3 -0.526 +candidate_22276407 chr16 48163864 48163904 AAAACAAAGCCAACAGAGAAGTCGTAGCCTCAACCCTCTA 0.45 0 -51.159 -314.6 -0.849 44.43 -0.082 +candidate_21732995 chr16 48174889 48174929 AAAACAAAACAAACTCAAGATTCTGCTTGAGTGACAGGGC 0.4 0 -49.933 -316.6 -0.86 42.35 -4.761 +candidate_22192745 chr16 48174894 48174934 AAAACAAACTCAAGATTCTGCTTGAGTGACAGGGCCTTCA 0.425 0 -50.821 -314.2 -0.849 43.96 -4.761 +candidate_22169674 chr16 48189398 48189438 AAAACAAACCCGGGTATGCCCCTTAGTTAAAACATTCCTT 0.4 268 -49.484 -309.7 -0.839 42.89 -1.519 +candidate_22278994 chr16 48190339 48190379 AAAACAAAGCCCAGAGAACTAGACGAAGAGCAAGCGTAGC 0.475 0 -52.566 -321.9 -0.868 45.11 -1.159 +candidate_21972372 chr16 48194702 48194742 AAAACAAAATTAGAGACAAGGACATGAGGTAAAATGGCCA 0.35 1 -47.43 -308.7 -0.842 40.21 -2.007 +candidate_22267986 chr16 49132159 49132199 AAAACAAAGCAAGTCTCCCTTGTCCAAGAAAAGAATGATC 0.375 0 -48.221 -312.5 -0.852 40.73 -1.672 +candidate_22283034 chr16 49153168 49153208 AAAACAAAGCTACAGAGTGAGAGTGGTAAGAAGATGTGTT 0.375 0 -47.976 -311.2 -0.849 40.62 0.434 +candidate_22281774 chr16 49153622 49153662 AAAACAAAGCGAACCAAAAGCAGTGCTTGGATGGTGAGAC 0.45 0 -52.541 -321.1 -0.866 45.11 -2.593 +candidate_22167603 chr16 49183383 49183423 AAAACAAACCCATGATCCAGACAGGCTCTGTGCAGATGCA 0.475 0 -53.059 -316.5 -0.849 46.65 -2.031 +candidate_21958297 chr16 50115922 50115962 AAAACAAAATGAGAAAGGCGTGGTTGAGCTAGCCTCCATA 0.425 1 -50.817 -314.6 -0.85 43.89 -2.082 +candidate_21859959 chr16 50118068 50118108 AAAACAAAAGAAATATCCAGTGGCCAAAACCAGAACCAGG 0.4 1 -49.379 -312.2 -0.847 42.35 -0.056 +candidate_22158341 chr16 50123922 50123962 AAAACAAACCAATTAAGCAGGTGAATATTGGCTGGGCTGA 0.4 0 -50.085 -312.1 -0.845 43.27 -1.525 +candidate_22157299 chr16 50159646 50159686 AAAACAAACCAAGCATCCATGGGTGGGGAGTGAGTAAGAA 0.45 0 -51.315 -311.5 -0.839 45.15 -1.17 +candidate_21778714 chr16 50167929 50167969 AAAACAAAACACCTCCCTAGGGCTAGTGCTCTAGCTAAGT 0.45 0 -50.398 -310.8 -0.84 44.09 -3.63 +candidate_21759804 chr16 50168025 50168065 AAAACAAAACAAGAACAACTTCCTGCACATCTTTGCTCTC 0.375 1 -49.12 -316.5 -0.862 41.25 -1.018 +candidate_22082335 chr16 50179734 50179774 AAAACAAACAAACAGCATGGTGACACATGTTTGTAGTCCC 0.4 4 -50.064 -316.7 -0.86 42.5 -4.814 +candidate_22220205 chr16 51104997 51105037 AAAACAAAGAAAGCAAAGGAGAATGACTGTGGGTTTTACT 0.35 1 -47.858 -310.4 -0.846 40.5 0.164 +candidate_21904481 chr16 51138374 51138414 AAAACAAAAGTAGGAAAGCATTTCATTGTGGAAGCTCTAG 0.35 28 -47.156 -311.9 -0.854 39.39 -1.702 +candidate_22090997 chr16 51143275 51143315 AAAACAAACAAAGTTAGTAAGGCACTTGTCAATTCCCATG 0.35 0 -47.539 -312.5 -0.854 39.78 -1.619 +candidate_22251468 chr16 51149587 51149627 AAAACAAAGATACAAGTAACACAATACAGACTGAGCTGGT 0.35 434 -47.152 -310.5 -0.849 39.59 -0.609 +candidate_22349222 chr16 51186899 51186939 AAAACAAATAACCGCATTAAAATATGGGGCTCAGAGCTAA 0.35 1115 -47.665 -310.3 -0.847 40.27 -2.237 +candidate_21887125 chr16 51197616 51197656 AAAACAAAAGCTACATGGCCGATGCTCTCTTCACATGTAG 0.425 0 -50.437 -317.6 -0.861 42.93 -3.304 +candidate_22404908 chr16 52134574 52134614 AAAACAAATGAAAGCCCGAGCGAACTTGCCTCACGTAATC 0.45 0 -52.532 -323.2 -0.873 44.75 -0.379 +candidate_21815172 chr16 53106595 53106635 AAAACAAAACCAGAGATTATTCAGTTGTCTAATGGGAACC 0.35 0 -46.565 -309.2 -0.847 39.04 -0.789 +candidate_22544870 chr16 53130099 53130139 AAAACAACAATTTCAACTAACCAGACTCCCTGTCCCAGAG 0.425 135 -49.51 -312.3 -0.847 42.6 -0.909 +candidate_22234415 chr16 53153978 53154018 AAAACAAAGACAACCACTGCATGTGGGCTGATGTGCCTTT 0.45 0 -52.904 -317.4 -0.853 46.19 -3.302 +candidate_22384493 chr16 53191793 53191833 AAAACAAATCAATCTGACATTAGGCAGTGTTCTGGGTTGA 0.375 0 -48.665 -311.3 -0.847 41.48 -0.969 +candidate_22249466 chr16 53198620 53198660 AAAACAAAGAGTCATTCAAGCTGAAGGGGAATTGGTAGGA 0.4 0 -49.067 -309.5 -0.84 42.38 -0.527 +candidate_22292624 chr16 54121626 54121666 AAAACAAAGGACAGCAATAGGTGAAACTAGGTCACTAAGG 0.4 0 -48.3 -311.4 -0.848 41.1 -1.042 +candidate_22363675 chr16 54122567 54122607 AAAACAAATAGAAACAAACCCATCCAAGAGGAGTAGAAGG 0.375 1049 -47.182 -308.7 -0.843 40.0 -0.822 +candidate_21951703 chr16 54143955 54143995 AAAACAAAATCTCACAGCAAACCTGTCCTTCTCTTCTGAC 0.4 0 -49.143 -314.6 -0.856 41.67 -1.602 +candidate_22306763 chr16 54145774 54145814 AAAACAAAGGTAGCAAATTCACCCAAGAGGAGTAGACAGC 0.425 1469 -49.8 -313.8 -0.851 42.73 -1.006 +candidate_22536165 chr16 55102898 55102938 AAAACAACAAGCTGTTCACATTTCTCTCCTGGGCGCTACT 0.45 0 -52.16 -317.4 -0.855 45.24 -0.472 +candidate_22283133 chr16 55104509 55104549 AAAACAAAGCTACCTCCCTCACAGACATGCCCACAGGCTA 0.5 8 -53.175 -314.6 -0.843 47.24 -2.189 +candidate_22416928 chr16 55125756 55125796 AAAACAAATGCATCAATCTAATGCTAGAAAGGAATCTGGC 0.35 1 -47.273 -311.8 -0.853 39.55 -1.472 +candidate_22188201 chr16 55133103 55133143 AAAACAAACTACATGCCAGGAGTTTCCTTTTCCTCTTGAG 0.4 0 -48.866 -312.4 -0.85 41.66 -1.159 +candidate_22276314 chr16 55137295 55137335 AAAACAAAGCCAAATCCTCTATTTTGTGAGAAGGGAAGGG 0.4 0 -48.757 -310.4 -0.844 41.84 -1.215 +candidate_22293865 chr16 55185288 55185328 AAAACAAAGGAGACCTACACTATACCATGCTTATAGATCA 0.35 0 -45.749 -305.5 -0.837 38.56 -0.904 +candidate_22431224 chr16 56124062 56124102 AAAACAAATGTGCTTTAATGGCTAGTGTGACTTTTGCCCA 0.375 0 -49.621 -313.9 -0.852 42.29 -0.979 +candidate_22422286 chr16 57100406 57100446 AAAACAAATGGAGTCTCAAGGTACCCATAAATTGTGTCTT 0.35 0 -47.088 -307.8 -0.841 39.92 -0.956 +candidate_22168417 chr16 57136534 57136574 AAAACAAACCCCAGCCAAGTACAGTAGTGACAGTTCCTTG 0.45 0 -50.869 -314.9 -0.851 44.01 -0.486 +candidate_22560764 chr16 57137711 57137751 AAAACAACACTTAGCAGGTTTCATTGACATAGGCTTTCAT 0.35 1 -47.876 -311.1 -0.849 40.41 -0.149 +candidate_22163643 chr16 57158167 57158207 AAAACAAACCATCTGGCACAATTAACTGACTGTACTTATC 0.35 0 -46.901 -311.8 -0.854 39.08 -0.316 +candidate_22270800 chr16 57163111 57163151 AAAACAAAGCAGAAACACTCTCTAGGAAGGGAATGCTTTT 0.375 0 -48.599 -310.8 -0.845 41.48 -2.288 +candidate_22205403 chr16 57181778 57181818 AAAACAAACTTCAATGTTCACACCACAAGATGCAGCAACA 0.375 0 -50.157 -316.7 -0.859 42.52 -0.512 +candidate_21888142 chr16 57184506 57184546 AAAACAAAAGCTGCAATAGGAGACTCTCTGCCAAGACTAA 0.4 0 -49.3 -312.4 -0.848 42.22 -0.562 +candidate_22134652 chr16 57199201 57199241 AAAACAAACAGCTCGAGAGAGCACTCCTCGTCCCCAGTGC 0.55 0 -55.472 -324.0 -0.866 48.74 -4.392 +candidate_22240123 chr16 58145273 58145313 AAAACAAAGACTAACACCCTAGGGCGTTCTCCAACTTCCC 0.475 0 -51.59 -315.0 -0.849 45.02 -0.95 +candidate_22530904 chr16 58147083 58147123 AAAACAACAACCGTAAGAAGGAGGCTGGAGGCTGATGCTC 0.5 0 -53.263 -319.0 -0.857 46.58 -0.912 +candidate_21967395 chr16 58168778 58168818 AAAACAAAATGTGCCTTAGCACAGTGGGCAATTTAGTATA 0.35 0 -47.893 -310.9 -0.848 40.46 -3.848 +candidate_22355635 chr16 60105525 60105565 AAAACAAATAATTGGTTTTGAAGGCTCAGCCCTAAACATG 0.35 1 -47.669 -311.7 -0.851 40.06 -2.722 +candidate_22348223 chr16 60138660 60138700 AAAACAAATAACAGTACATGCTGGCAAAGAGGTAGAGTAA 0.35 232 -47.141 -309.9 -0.847 39.67 -1.292 +candidate_22548148 chr16 60142430 60142470 AAAACAACACAATCAGGTCTGTCACAGCAACACTCCATAA 0.4 60 -49.897 -314.3 -0.853 42.67 0.281 +candidate_22070415 chr16 60163443 60163483 AAAACAAACAAACAAACATGGTCAGAATGCAGAGTTATGG 0.35 4 -47.922 -314.0 -0.858 40.03 0.483 +candidate_22297174 chr16 60175876 60175916 AAAACAAAGGCAAGCAGGGATGTTTGTTCTAATTAAGCAT 0.35 0 -48.286 -311.2 -0.848 40.92 -2.408 +candidate_22406075 chr16 60185472 60185512 AAAACAAATGAACAATGATCTCTCCTATATGGTCACAAGG 0.35 0 -46.22 -308.7 -0.846 38.68 -0.44 +candidate_22550604 chr16 61104641 61104681 AAAACAACACAGAGATACACACACATGCATGTACCCACAC 0.425 403 -50.454 -317.4 -0.861 42.98 -0.699 +candidate_21890845 chr16 61173693 61173733 AAAACAAAAGGAAGAAACACAAAACCTGTGGAGTTCATGT 0.35 2 -48.283 -311.6 -0.849 40.85 -2.312 +candidate_21791592 chr16 61181111 61181151 AAAACAAAACAGGGAGGAGATGCCTTGGGTCCTGGAAATG 0.475 0 -51.861 -313.1 -0.842 45.69 -2.193 +candidate_22231544 chr16 62146595 62146635 AAAACAAAGAATGGACAGCCATGCCACAATAATGGAAGAA 0.375 0 -49.106 -311.4 -0.846 42.03 -2.764 +candidate_22551772 chr16 62190688 62190728 AAAACAACACAGTCAGGTCTGTGACAGCAATACCCCATTA 0.425 199 -50.358 -312.9 -0.846 43.59 -3.865 +candidate_22251480 chr16 62192811 62192851 AAAACAAAGATACAATGGTTGAGGATATGCCTCTGTGGAT 0.375 1 -47.891 -308.2 -0.839 40.98 -2.622 +candidate_22208932 chr16 62193639 62193679 AAAACAAACTTTCAGAAGGAAGGCATAGTTCCTACAAAAG 0.35 0 -46.886 -310.7 -0.851 39.23 -1.925 +candidate_21852860 chr16 63108540 63108580 AAAACAAAACTTTGGTGGCTGGTAATGTAGATCAATGTTG 0.35 1 -47.57 -312.5 -0.854 39.82 -0.929 +candidate_22154498 chr16 63139745 63139785 AAAACAAACCAAAGGAGACAAGCTTAGAATGTAGTAGACA 0.35 0 -46.913 -309.3 -0.846 39.47 -0.278 +candidate_21978114 chr16 63152879 63152919 AAAACAAAATTGAGGGACTCCAGAATACAGAAAGAGCTGC 0.4 0 -48.99 -313.3 -0.852 41.68 -2.078 +candidate_22165988 chr16 63157019 63157059 AAAACAAACCCAATCAAGACCCCTAAATGGTAGCATTTCT 0.375 13 -48.311 -308.0 -0.837 41.55 -2.145 +candidate_22543874 chr16 63183017 63183057 AAAACAACAATGTTGAAAGAAGCCAATATTTGCAGGGGTG 0.375 0 -49.146 -314.2 -0.855 41.64 -1.842 +candidate_22195602 chr16 64101875 64101915 AAAACAAACTCCTCTGTCCCAGGCTAATGGTTTATTTGTC 0.4 0 -48.71 -311.5 -0.847 41.61 -0.439 +candidate_22080830 chr16 64121803 64121843 AAAACAAACAAACACCATAAGAAGAGCCAGCCAGAATAGT 0.375 0 -48.658 -311.2 -0.846 41.49 2.537 +candidate_22267124 chr16 64124738 64124778 AAAACAAAGCAAGACCCAACAGCTACAAGAAAACTGAAAT 0.35 747 -48.407 -312.5 -0.852 40.87 -0.889 +candidate_22409669 chr16 64127159 64127199 AAAACAAATGACATCTCATATTGGTGAGGACGTGAAATAC 0.35 69 -46.888 -312.5 -0.856 38.96 -1.445 +candidate_22275089 chr16 64170152 64170192 AAAACAAAGCATTAGCAAGTGCAATAGCATTGCTACTAGA 0.35 0 -48.129 -313.4 -0.855 40.38 -4.217 +candidate_22263227 chr16 65100596 65100636 AAAACAAAGCAAACAAAACAAAAGCCAGCCCTGTTTCCCT 0.4 24 -51.317 -315.1 -0.85 44.35 -1.016 +candidate_21884557 chr16 65100610 65100650 AAAACAAAAGCCAGCCCTGTTTCCCTGATCCTCAGTTTCC 0.475 2 -52.234 -314.9 -0.847 45.86 -1.884 +candidate_22185338 chr16 65122594 65122634 AAAACAAACTAAACCCATAGACAACTGTATTGCCTCCTCC 0.4 1 -48.427 -311.0 -0.847 41.33 -0.619 +candidate_22427785 chr16 65176726 65176766 AAAACAAATGTAGACCTGAGAACTTCATGTGAGAGATGGG 0.4 0 -48.207 -311.4 -0.849 40.98 -0.665 +candidate_22128391 chr16 66105689 66105729 AAAACAAACAGAAAGGAAAGATTCTGGAAGAGGCACAGGA 0.4 6 -49.388 -311.0 -0.844 42.55 -2.295 +candidate_22137318 chr16 66107612 66107652 AAAACAAACAGGGTCAAGTTGGTTCAACACTTGTGTTTTA 0.35 0 -48.452 -312.7 -0.852 40.9 -2.995 +candidate_22235562 chr16 66120355 66120395 AAAACAAAGACACTGAGCTGGGAGAAAAGATTGCTCTCTT 0.4 0 -49.524 -312.5 -0.848 42.48 -1.822 +candidate_22139014 chr16 66135997 66136037 AAAACAAACAGTGCAACTTGAGATTCTATGCCAACAGAGA 0.375 0 -48.942 -313.5 -0.853 41.49 -1.263 +candidate_21875941 chr16 66143845 66143885 AAAACAAAAGATTGGAAATCCACAGTAATCCATGCCAGTA 0.35 0 -47.461 -308.7 -0.842 40.25 -1.092 +candidate_22202771 chr16 66144420 66144460 AAAACAAACTGTGACAAAGAGCCATCATTTCACGATCTTA 0.35 0 -48.043 -313.5 -0.856 40.26 -0.316 +candidate_22412801 chr16 66173972 66174012 AAAACAAATGAGTTAAGCCATAAATGTCAGGCAAGCCTTT 0.35 0 -48.286 -311.2 -0.848 40.92 -1.918 +candidate_22478627 chr16 67150981 67151021 AAAACAACAAAACAAGTAAACACTAGCATTCACTCACTGG 0.35 0 -47.647 -314.5 -0.86 39.62 0.461 +candidate_22077731 chr16 67178091 67178131 AAAACAAACAAACAAGAACAACAAAATCCCAGCCAGATGG 0.375 91 -49.229 -314.5 -0.855 41.7 -0.142 +candidate_22143879 chr16 68111670 68111710 AAAACAAACATCCGTGTTGACAGCCCACTATTTCACAGAA 0.4 0 -50.26 -315.5 -0.855 42.94 -1.422 +candidate_21842556 chr16 68125708 68125748 AAAACAAAACTCATCACAATTGTAAGCAGCCACTTGAGTT 0.35 5 -48.508 -313.5 -0.854 40.84 -1.541 +candidate_22248005 chr16 68163705 68163745 AAAACAAAGAGGCCTTGACGATTCTATGGAACACACGTGA 0.425 0 -50.953 -317.0 -0.858 43.68 -0.735 +candidate_21880288 chr16 68164199 68164239 AAAACAAAAGCAAGGCTGTTGAACACCTAAGCCAACAGTA 0.4 1 -50.442 -315.0 -0.853 43.25 -3.348 +candidate_22270492 chr16 68171225 68171265 AAAACAAAGCACTGGAAGTCAAATCACGGGGTCTATACTG 0.425 4 -49.929 -315.2 -0.855 42.67 -0.409 +candidate_21670946 chr16 68188874 68188914 AAAACAAAACAAAACAAACCGAAAGTACCTGGACATACGA 0.35 50 -48.443 -314.8 -0.859 40.56 -0.206 +candidate_21732049 chr16 68188879 68188919 AAAACAAAACAAACCGAAAGTACCTGGACATACGAACCTT 0.375 0 -49.084 -314.2 -0.855 41.56 -0.206 +candidate_22171832 chr16 68188884 68188924 AAAACAAACCGAAAGTACCTGGACATACGAACCTTTCTAT 0.375 0 -48.21 -311.9 -0.85 40.81 -0.605 +candidate_21833371 chr16 69120689 69120729 AAAACAAAACGATGTAGTGTATCTCAGGGTAGACATGGTA 0.375 0 -47.458 -310.0 -0.846 40.15 -0.67 +candidate_22532719 chr16 70126324 70126364 AAAACAACAACTGGCAACAAACAAACGCTTGAGAGGATGT 0.4 0 -51.199 -318.3 -0.861 43.67 -1.268 +candidate_21838265 chr16 70179074 70179114 AAAACAAAACTACAAAATCATGCCGAGGAAAGACAGTGAA 0.35 1 -48.253 -313.4 -0.855 40.54 0.874 +candidate_22322736 chr16 70183950 70183990 AAAACAAAGTCTGGGGTTTGGCACTACCACATCCTATTCT 0.425 0 -50.046 -310.2 -0.839 43.63 -1.513 +candidate_21687718 chr16 70191486 70191526 AAAACAAAACAAAACAGAACCGCACAGTGGAGGAGCAATA 0.4 17 -50.708 -316.6 -0.857 43.33 -1.469 +candidate_21784795 chr16 70191491 70191531 AAAACAAAACAGAACCGCACAGTGGAGGAGCAATACCATT 0.425 2 -51.38 -316.0 -0.853 44.38 -1.469 +candidate_22410844 chr16 71175515 71175555 AAAACAAATGACTTTACTGGCCCTGCCTACTTTTCTTATT 0.35 0 -47.423 -308.6 -0.842 40.22 -1.389 +candidate_22311802 chr16 72102985 72103025 AAAACAAAGTAAATGTCATAAGTTCTCCTCCTCTTGTCCT 0.35 2 -46.505 -307.0 -0.84 39.29 0.281 +candidate_22359397 chr16 72145410 72145450 AAAACAAATACATGAATAAGTGGGTGGGGTGACACAATGT 0.375 1 -48.554 -309.7 -0.842 41.59 -0.949 +candidate_21924434 chr16 72152772 72152812 AAAACAAAATAACCAGTACTTGTGACTTCCTGGCTTCCAT 0.375 0 -48.419 -310.0 -0.843 41.37 -1.332 +candidate_22562354 chr16 72178247 72178287 AAAACAACAGAAAATGAGTGAGTTGTTTGAAGGCAGCATT 0.35 1 -48.791 -314.0 -0.855 41.12 -3.941 +candidate_22442846 chr16 73115936 73115976 AAAACAAATTATCTGGGTTTGGAGAGATGGTTCTGTGGTT 0.375 551 -48.184 -308.4 -0.839 41.32 -0.851 +candidate_22136880 chr16 73124496 73124536 AAAACAAACAGGCTTCTGGATAGAGGAAGAGGTGTGGAGA 0.45 0 -50.491 -310.8 -0.839 44.21 -1.392 +candidate_21884867 chr16 73131946 73131986 AAAACAAAAGCCATCGTCTTAAGGGTATTATGTGGAAATG 0.35 0 -47.059 -311.4 -0.852 39.34 -0.109 +candidate_21698710 chr16 73144761 73144801 AAAACAAAACAAAACGGCAAATCCTAACTATGGAGTGGAT 0.35 3 -48.0 -311.1 -0.848 40.57 -0.505 +candidate_21834208 chr16 73144766 73144806 AAAACAAAACGGCAAATCCTAACTATGGAGTGGATCCTTT 0.375 0 -48.502 -310.3 -0.844 41.43 -1.249 +candidate_22294609 chr16 73178356 73178396 AAAACAAAGGAGGAGAAGAAAAGGAAGAGGAGAAGGAGGA 0.425 1202 -49.0 -307.2 -0.833 42.77 998.226 +candidate_22135831 chr16 73178578 73178618 AAAACAAACAGGATATTGAATGCCATGAAGGAGGCTGTTC 0.4 0 -49.293 -313.2 -0.851 42.08 -2.488 +candidate_21790463 chr16 73187251 73187291 AAAACAAAACAGGAAGGGAATGACTGGAGCCATTCAAGAC 0.425 0 -50.159 -313.6 -0.849 43.22 -1.875 +candidate_22168459 chr16 74173913 74173953 AAAACAAACCCCAGGCACATTCCTTATAGCCGTGTTATGC 0.45 0 -51.546 -316.6 -0.855 44.59 -0.892 +candidate_22143830 chr16 74196682 74196722 AAAACAAACATCCCCAAAGGCTTTGATATCCCATTCAGCA 0.4 0 -49.85 -310.5 -0.84 43.23 -1.169 +candidate_22518902 chr16 75105564 75105604 AAAACAACAACAACAACAACAACAATCTCAGTGCATATCC 0.35 485 -48.158 -315.6 -0.862 40.09 1.114 +candidate_22522176 chr16 75109734 75109774 AAAACAACAACAACACTCCAAAACAAACTGGAGAAGCAAG 0.375 7 -49.306 -316.5 -0.862 41.48 -3.215 +candidate_22201014 chr16 75109753 75109793 AAAACAAACTGGAGAAGCAAGTGGTGGAGTATCAGAGGTA 0.425 0 -49.706 -311.1 -0.843 43.04 0.084 +candidate_22334198 chr16 75129428 75129468 AAAACAAAGTTTGAGATTAAGCTCAAACCTTGCAGAGCTA 0.35 0 -47.914 -312.1 -0.852 40.31 -5.062 +candidate_21979283 chr16 75142524 75142564 AAAACAAAATTGTACAGAAAGGAACTACTCAGAGCCATGC 0.375 2 -48.205 -313.6 -0.856 40.55 -1.415 +candidate_22358340 chr16 75187595 75187635 AAAACAAATACAGACTCTTGTAGCACAGCAGTAGAAACAG 0.375 0 -47.864 -314.5 -0.86 39.99 -0.578 +candidate_22132000 chr16 75198974 75199014 AAAACAAACAGAGTGTGACATGTGTCGATTTCAGACAAAA 0.35 0 -48.506 -315.7 -0.862 40.51 -0.801 +candidate_22111571 chr16 76106687 76106727 AAAACAAACAAGGTCATAGCTCAGGGCTGTTCTGCCCTAT 0.45 0 -51.337 -312.7 -0.843 44.98 -4.415 +candidate_22385414 chr16 76107708 76107748 AAAACAAATCACATCGTATCACATCTCTCTGCCTAAACCA 0.375 0 -48.293 -312.2 -0.851 40.87 1.164 +candidate_22328152 chr16 76113352 76113392 AAAACAAAGTGTGGGGAGCCGCGCGGGTAATAACAAAGCA 0.5 0 -55.261 -323.2 -0.864 48.4 -1.451 +candidate_22461655 chr16 76185390 76185430 AAAACAAATTTCTGGGGTGACACCTGCCTTCTTCCCTGTG 0.475 0 -52.21 -315.0 -0.847 45.82 -0.539 +candidate_22350221 chr16 76188356 76188396 AAAACAAATAAGAAACTCACAAAGAGGAAGGAAGGGAGGG 0.4 51 -48.247 -309.3 -0.842 41.36 -1.359 +candidate_21696605 chr16 76195412 76195452 AAAACAAAACAAAACCCTCTAAGCTTCTGTTCTTTTCCTC 0.35 2 -47.304 -311.8 -0.853 39.59 0.388 +candidate_21824607 chr16 76195417 76195457 AAAACAAAACCCTCTAAGCTTCTGTTCTTTTCCTCCTGGT 0.4 0 -49.143 -309.7 -0.84 42.45 0.044 +candidate_22309582 chr16 77139315 77139355 AAAACAAAGGTTCTTCTAAGTGGTAGTGGGACAGAAGGAA 0.4 0 -48.553 -308.8 -0.839 41.83 -1.045 +candidate_22559612 chr16 77145310 77145350 AAAACAACACTGAGATTCCATCTTAGACCTGTCAGAATGG 0.4 1346 -48.207 -311.4 -0.849 40.98 -1.808 +candidate_21875790 chr16 78106632 78106672 AAAACAAAAGATTCCAAAATAGGCCAAGCAGGTGCAACCA 0.4 2 -50.648 -313.5 -0.848 43.76 -1.809 +candidate_22221967 chr16 78121594 78121634 AAAACAAAGAAATCAACAGGCTATCACATCTTCCCTTTCT 0.35 0 -47.299 -308.6 -0.843 40.06 0.498 +candidate_21943614 chr16 78146038 78146078 AAAACAAAATCAAGACTACAGCAGGAAAATGGGTGGAGGT 0.4 2 -49.516 -310.6 -0.842 42.78 0.131 +candidate_22088458 chr16 78160661 78160701 AAAACAAACAAAGAAAAGAAACTGGCAAGGATGCAGGGAA 0.375 21 -49.607 -312.8 -0.849 42.44 -1.949 +candidate_22272621 chr16 78164887 78164927 AAAACAAAGCAGGGCTGCCTTGGCTAGAAGGACAAGTGAG 0.5 0 -53.425 -318.2 -0.854 46.93 -2.985 +candidate_22067700 chr16 79178510 79178550 AAAACAAACAAACAAACAACCTGTCTGCCTCTTCCCTCAA 0.4 14 -50.29 -313.7 -0.849 43.27 0.331 +candidate_21866445 chr16 80127300 80127340 AAAACAAAAGAATTCCATTCCTAATCATTCCCCAAAGGCT 0.35 1 -47.432 -306.5 -0.835 40.55 -0.349 +candidate_21961983 chr16 80154036 80154076 AAAACAAAATGCTCACAGAGGTGAAGGTGATCTACACAAA 0.375 0 -48.704 -312.3 -0.85 41.37 -3.118 +candidate_22519488 chr16 80166974 80167014 AAAACAACAACAACAACAACACCTCTGTGATTACTGGAGA 0.375 32 -48.814 -313.0 -0.852 41.41 -1.649 +candidate_22277386 chr16 80198612 80198652 AAAACAAAGCCAGAAAGTGAATTACTGACCCAAGATTCTA 0.35 0 -47.157 -308.8 -0.844 39.85 -0.967 +candidate_22188735 chr16 81153500 81153540 AAAACAAACTACTGCAGTCACTCAGGAAATTGTTGAGAAT 0.35 0 -47.717 -311.5 -0.851 40.15 -1.831 +candidate_22207174 chr16 81171525 81171565 AAAACAAACTTGCAAAGTCATTGTGTTTGTTTGTGTTGGC 0.35 1 -49.48 -319.0 -0.869 41.22 -5.442 +candidate_21686514 chr16 81179833 81179873 AAAACAAAACAAAACACTGGAAGCTTCTAAGTGACAGAGG 0.375 1 -48.401 -314.2 -0.857 40.7 -1.847 +candidate_21780699 chr16 81179838 81179878 AAAACAAAACACTGGAAGCTTCTAAGTGACAGAGGATACA 0.375 0 -48.079 -310.9 -0.847 40.8 -1.847 +candidate_22164411 chr16 82101203 82101243 AAAACAAACCATTGAAACACTGATGAACCAAATAGGGGAA 0.35 1 -47.785 -308.9 -0.842 40.63 -2.151 +candidate_21774421 chr16 82180535 82180575 AAAACAAAACACAGACTCTCCCTCTCCCAGTAGCCATCAT 0.45 17 -50.66 -311.0 -0.839 44.39 0.751 +candidate_22142541 chr16 83147797 83147837 AAAACAAACATATCTAGGCAAGACTAACCAGTGGCCACAG 0.425 0 -49.693 -313.6 -0.851 42.63 -1.459 +candidate_21961679 chr16 83169237 83169277 AAAACAAAATGCCTTCTATCCACCTTCAGAAGACTTCAGT 0.375 0 -48.151 -309.7 -0.843 41.08 -1.865 +candidate_22393590 chr16 83170773 83170813 AAAACAAATCCTACCTCCAGAGAAAGAGAGAGAGAGAGAT 0.4 118 -47.311 -306.1 -0.834 40.66 -0.199 +candidate_21798346 chr16 83195310 83195350 AAAACAAAACATGAAATATGGTGACCAGAGTAAAGGGGAG 0.375 0 -47.523 -309.6 -0.845 40.29 -0.715 +candidate_22235188 chr16 84110136 84110176 AAAACAAAGACACAGATACTTAACTGGGTATACAAGTGCA 0.35 1 -46.972 -309.7 -0.847 39.48 -1.767 +candidate_22199438 chr16 84113940 84113980 AAAACAAACTGATACACGTGCAAAAGAGTGAATTTCCCCA 0.375 0 -49.377 -314.4 -0.855 41.9 -1.149 +candidate_22363266 chr16 84123068 84123108 AAAACAAATACTTTCTACAGTGAGGAAAATCCACAGAGGT 0.35 0 -46.816 -307.9 -0.842 39.55 -0.726 +candidate_21848800 chr16 84137050 84137090 AAAACAAAACTGTGATGTATAGTTGTGAAAGGGGACAGCT 0.375 0 -48.489 -311.0 -0.846 41.3 -1.906 +candidate_22448911 chr16 84178196 84178236 AAAACAAATTCTACTGTCCTACTCACACACACACACACAC 0.4 490 -49.099 -316.2 -0.861 41.37 0.781 +candidate_21864202 chr16 84196585 84196625 AAAACAAAAGAATACACTGTCTTCTCAGTACCAAAAGGTG 0.35 1010 -46.787 -311.5 -0.854 38.98 -1.492 +candidate_22235294 chr16 85110795 85110835 AAAACAAAGACACATGCGTACACACATGGCCTCATTCAGA 0.425 4 -51.412 -317.8 -0.859 44.13 -1.452 +candidate_21734516 chr16 85140354 85140394 AAAACAAAACAAAGAAGAAGGATAGAAGGAACCAGAGAGA 0.35 276 -46.619 -307.3 -0.841 39.39 0.274 +candidate_22226467 chr16 85140359 85140399 AAAACAAAGAAGAAGGATAGAAGGAACCAGAGAGATAAAG 0.35 295 -45.506 -306.9 -0.843 38.04 0.274 +candidate_21778745 chr16 85151414 85151454 AAAACAAAACACCTCTCCTAGACCAGAGACTAGGTGGTGC 0.475 0 -50.986 -313.9 -0.848 44.43 -3.876 +candidate_22008965 chr16 85166641 85166681 AAAACAAACAAAACCAGAAACCAAACCCCTTTTACCTGTG 0.375 4 -48.886 -312.7 -0.851 41.54 0.471 +candidate_22535706 chr16 85174980 85175020 AAAACAACAAGCAGTTTCTGCCACTGCCCAGTTCCTGCTT 0.475 0 -53.894 -318.7 -0.854 47.34 -2.765 +candidate_22399452 chr16 86120245 86120285 AAAACAAATCTGATCTGCATTTTGATGCTGTACCGCTAAC 0.375 0 -48.937 -317.0 -0.864 40.95 -2.372 +candidate_22324337 chr16 86170469 86170509 AAAACAAAGTGACTAGGATAGGGAAGGTTGGAACTTTTAT 0.35 0 -46.394 -305.4 -0.835 39.39 -0.389 +candidate_21982954 chr16 86199584 86199624 AAAACAAAATTTGCAAGCATCTGGAATGGCTGGTAAGTGC 0.4 0 -50.602 -317.3 -0.86 43.08 -0.785 +candidate_22007903 chr16 87129728 87129768 AAAACAAACAAAACACTCAGTTCATCGGGTAAAGTCTAGG 0.375 0 -48.032 -313.8 -0.857 40.3 -0.469 +candidate_22133710 chr16 87137068 87137108 AAAACAAACAGCAGTATCCAGATCAGCTGCATCCCTCCCA 0.475 0 -52.395 -314.1 -0.844 46.21 -2.625 +candidate_22563296 chr16 87145435 87145475 AAAACAACAGAAAGCCCACATACACATGGAAGCTGACCAA 0.425 1180 -51.121 -314.5 -0.849 44.3 -0.709 +candidate_22402937 chr16 87187631 87187671 AAAACAAATCTTTGTGAGTTCAAGGCCTGCCCACTCTCCA 0.45 214 -51.875 -314.2 -0.846 45.42 -2.148 +candidate_22356305 chr16 88124318 88124358 AAAACAAATACAAAACAAACCACTCTCACCCCAAGAAAGC 0.375 10 -48.77 -313.7 -0.854 41.24 0.854 +candidate_22160134 chr16 88124329 88124369 AAAACAAACCACTCTCACCCCAAGAAAGCAAGACACAAAA 0.4 1 -50.29 -313.7 -0.849 43.27 0.854 +candidate_22385976 chr16 88127352 88127392 AAAACAAATCACTCACTCCATCCTAGAAGAGCAAACTGCC 0.425 0 -49.873 -314.4 -0.853 42.73 -0.709 +candidate_22325960 chr16 88141120 88141160 AAAACAAAGTGCTTCATCAAATGCAGGCACCGGCTGGATA 0.45 0 -52.805 -318.2 -0.856 45.93 -1.96 +candidate_21785540 chr16 88192867 88192907 AAAACAAAACAGAATAGCAGTTAGGCGGTAGGAGGGAGAA 0.425 1 -49.954 -312.0 -0.845 43.22 0.241 +candidate_22167297 chr16 88195353 88195393 AAAACAAACCCAGTGATTGGCATGGCTCGAAATGTTTTCT 0.4 0 -50.811 -315.4 -0.853 43.65 -1.358 +candidate_22389140 chr16 90101042 90101082 AAAACAAATCATGAGCCCACCTTTGCAGTGTTACCTTACA 0.4 0 -49.955 -312.9 -0.848 42.97 -0.516 +candidate_22302160 chr16 90124634 90124674 AAAACAAAGGGAAGCCCAGCAGCAAGGCAGCTGCATCTAA 0.5 0 -54.655 -318.5 -0.851 48.46 -5.807 +candidate_22126700 chr16 90130090 90130130 AAAACAAACACTTCTTCCCTTTATTTGCTTTCTCCAGCAT 0.35 10 -48.058 -310.6 -0.847 40.72 -0.945 +candidate_21849939 chr16 90133192 90133232 AAAACAAAACTTACCATAGCTAGAGTGATTCACAAACCCC 0.375 0 -47.614 -310.9 -0.849 40.21 -0.469 +candidate_21699937 chr16 90136408 90136448 AAAACAAAACAAAACTCAATTAGCCACAGAGCACCAAGAG 0.375 3 -48.912 -315.3 -0.859 41.17 -0.226 +candidate_21841895 chr16 90136413 90136453 AAAACAAAACTCAATTAGCCACAGAGCACCAAGAGGACAC 0.425 0 -50.463 -316.2 -0.857 43.19 -1.055 +candidate_22108944 chr16 90137828 90137868 AAAACAAACAAGCAAAGACAACCCACAGGGCTGGTAATAC 0.425 5 -50.663 -315.5 -0.854 43.55 -1.049 +candidate_22439916 chr16 90141470 90141510 AAAACAAATTACTGGGGAAGAGCCAGGAGAATCATCCAAG 0.425 0 -49.361 -310.6 -0.842 42.68 -2.242 +candidate_22161492 chr16 90147842 90147882 AAAACAAACCAGCAGGGTAACAGTCTTTAGCTAATTTGTG 0.375 0 -48.277 -313.3 -0.855 40.68 -2.399 +candidate_22245248 chr16 90156432 90156472 AAAACAAAGAGATCTGTCTTCCTCTGCCTCCCAAGTGCTG 0.475 2400 -51.655 -315.5 -0.851 45.02 -0.792 +candidate_22193843 chr16 90164453 90164493 AAAACAAACTCAGGACTTTGTGAGCATCCATTATAGCTCA 0.375 0 -48.31 -311.1 -0.847 41.06 -2.733 +candidate_21834136 chr16 90170058 90170098 AAAACAAAACGGAGGAATAAATAGCCGCTGTCTCATAGCA 0.4 0 -49.874 -315.3 -0.856 42.48 -1.179 +candidate_22279207 chr16 90183096 90183136 AAAACAAAGCCCATTATCTTACACAGAGCAGTGCTGAGGC 0.45 0 -51.432 -317.2 -0.857 44.35 -0.789 +candidate_21676743 chr16 90188443 90188483 AAAACAAAACAAAACAACAACAACAAACTCAGCTAGCTCC 0.35 480 -48.544 -316.7 -0.865 40.4 0.544 +candidate_21749831 chr16 90188448 90188488 AAAACAAAACAACAACAACAAACTCAGCTAGCTCCCATTA 0.35 12 -48.297 -312.7 -0.852 40.7 0.544 +candidate_22510637 chr16 90188453 90188493 AAAACAACAACAACAAACTCAGCTAGCTCCCATTAATAAG 0.35 0 -47.184 -312.3 -0.855 39.36 0.544 +candidate_21891758 chr16 90196260 90196300 AAAACAAAAGGACAAAGATTGACAGCATCCAAGGAGGGAA 0.4 0 -49.661 -310.9 -0.842 42.92 -1.062 +candidate_22243294 chr16 91118707 91118747 AAAACAAAGAGAAGCAGCACTGGGAGACAAGGTCACCAAT 0.45 0 -51.772 -314.5 -0.847 45.24 -1.217 +candidate_22174961 chr16 91126021 91126061 AAAACAAACCTCCACAGAGCTTACTCAATTCTCTGAAGGA 0.4 0 -48.864 -310.6 -0.844 41.95 -3.04 +candidate_22534710 chr16 91136208 91136248 AAAACAACAAGACTATAGGGGACATCTCATTCAAACACTA 0.35 2 -46.426 -307.2 -0.841 39.16 0.814 +candidate_22238881 chr16 91149318 91149358 AAAACAAAGACCCAGAGAAGTTAAGTCATGCAAGGGTATA 0.375 0 -47.688 -308.4 -0.841 40.69 -1.642 +candidate_21814235 chr16 91158849 91158889 AAAACAAAACCACTGACTCACCAAGATAGACTTGGGTGGA 0.425 14 -50.061 -311.3 -0.842 43.47 -4.895 +candidate_21956780 chr16 91182411 91182451 AAAACAAAATGAAGCCAGCTTTGAACACACTGTGTTGGCA 0.4 0 -51.419 -317.9 -0.859 44.02 -2.782 +candidate_21951625 chr16 91185437 91185477 AAAACAAAATCTCAACCAAATCCTAGCCTACTGCCTTTTA 0.35 1 -47.285 -308.4 -0.842 40.07 -0.316 +candidate_22556004 chr16 91190766 91190806 AAAACAACACCGTGGCCCAGCTAATTAGAACACACACTTC 0.45 0 -51.737 -318.9 -0.861 44.46 0.071 +candidate_21897548 chr16 91199660 91199700 AAAACAAAAGGCCACTCTCTCCCCTTCTCCAGCTTCTTTT 0.45 0 -51.291 -311.6 -0.839 45.11 -0.542 +candidate_22279494 chr16 92122139 92122179 AAAACAAAGCCCCTGACTAATGAATTAAAGAGGAATGCAG 0.375 1 -47.931 -311.0 -0.848 40.6 0.161 +candidate_21880075 chr16 92131398 92131438 AAAACAAAAGCAAGCAAACAACATCATCACCATCATCACC 0.375 75 -49.454 -316.4 -0.861 41.68 2.074 +candidate_22168403 chr16 92162192 92162232 AAAACAAACCCCAGATGCATGCCCATAGGTCAATCAGATT 0.425 5 -50.591 -310.9 -0.839 44.22 0.004 +candidate_22513714 chr16 92173690 92173730 AAAACAACAACAACAACAAAACCCCAAGTCCCCAGCACCA 0.45 148 -52.779 -315.6 -0.847 46.34 0.624 +candidate_22175427 chr16 92181887 92181927 AAAACAAACCTCTCATCAGGATGGAAAAGTACCAACCTGT 0.4 46 -49.036 -309.5 -0.84 42.34 -3.853 +candidate_22308271 chr16 93102076 93102116 AAAACAAAGGTGAGCAGGCTAATTCGGTGCCTGGAGCCAA 0.5 0 -54.369 -318.4 -0.851 48.11 -4.151 +candidate_22203018 chr16 93137335 93137375 AAAACAAACTGTGTACCAGCCCAGACCCTGCTGTGGAACC 0.525 0 -54.307 -318.4 -0.851 48.13 -2.521 +candidate_22267784 chr16 93148087 93148127 AAAACAAAGCAAGGCAAGGTCAAGAGGTAGCCTGGGAGAG 0.5 0 -52.876 -316.1 -0.849 46.59 -2.292 +candidate_22317162 chr16 93153957 93153997 AAAACAAAGTATGAAGGAGAAATGTTGGTGAGGGTTGCAT 0.375 0 -48.733 -310.5 -0.844 41.69 -0.516 +candidate_22373867 chr16 93179825 93179865 AAAACAAATATCATTGCCTTGTAGGGCAGCTTCAGGTTCG 0.425 0 -50.608 -316.5 -0.857 43.32 -2.418 +candidate_22518786 chr16 94100674 94100714 AAAACAACAACAACAACAACAACAACCATGTTCTGCATCC 0.375 666 -49.844 -318.0 -0.865 41.92 -1.222 +candidate_22406780 chr16 94123970 94124010 AAAACAAATGAAGAAATGCCCGGCCTTGGGGACAGAAGCC 0.5 0 -53.99 -318.3 -0.852 47.64 -1.882 +candidate_22519056 chr16 94128515 94128555 AAAACAACAACAACAACAACAACATCATTACTGTGGGCCC 0.4 251 -50.305 -316.6 -0.859 42.82 0.471 +candidate_22516171 chr16 94158568 94158608 AAAACAACAACAACAACAACAAAATACTGGTCCTCTCCTC 0.375 144 -48.36 -313.6 -0.855 40.74 0.344 +candidate_22420280 chr16 94159288 94159328 AAAACAAATGCTTCCTCCCTTAAGTTGCACAGCCTAGGAA 0.425 2 -50.595 -312.3 -0.844 43.99 -0.442 +candidate_21846752 chr16 94180536 94180576 AAAACAAAACTGCATGTCATCCAGAGGCCAGAGAGCCTAG 0.475 0 -51.883 -316.1 -0.852 45.21 -2.782 +candidate_22237073 chr16 95114060 95114100 AAAACAAAGACATCATGAAATTTGCAGGCAATGGACAGAA 0.35 1007 -48.645 -312.8 -0.852 41.12 -0.312 +candidate_22070025 chr16 95161906 95161946 AAAACAAACAAACAAACAGGAGCACAGTCATAATATTCCC 0.35 14 -47.425 -312.2 -0.854 39.68 0.491 +candidate_21893541 chr16 96106024 96106064 AAAACAAAAGGATACTTATGGGCTGGGGAGATGGCTCATT 0.425 249 -49.897 -308.5 -0.834 43.72 -3.226 +candidate_21868748 chr16 96107225 96107265 AAAACAAAAGACCAGGGATGGTGGCATAGCTCAGTAAAGG 0.45 3 -50.72 -313.2 -0.846 44.1 -3.572 +candidate_22519965 chr16 96109738 96109778 AAAACAACAACAACAACAAGAAGCTACTGATTATGGTGGC 0.375 19 -48.826 -315.4 -0.859 41.05 -0.381 +candidate_22490642 chr16 96113584 96113624 AAAACAACAAAGCTTCATCCAGCATCCACAGCACCAGCAC 0.475 0 -53.503 -321.1 -0.863 46.43 -1.825 +candidate_22337724 chr16 96115203 96115243 AAAACAAATAAAACACACATCTCGAAACTCCAATGGCGGG 0.4 1 -50.103 -317.7 -0.863 42.39 0.554 +candidate_22264711 chr16 96115374 96115414 AAAACAAAGCAAAGCAAAATCAGCAGACAGTCTGTTTCCC 0.4 5 -50.413 -317.7 -0.862 42.78 -1.179 +candidate_22133726 chr16 96130849 96130889 AAAACAAACAGCAGTGGCTACCACACAGTCATAGACCTGA 0.45 4 -51.448 -315.2 -0.85 44.7 -2.202 +candidate_21785278 chr16 96178155 96178195 AAAACAAAACAGAAGGCCACAAGGAAAAGGCTAACAGCCT 0.425 0 -51.296 -313.9 -0.847 44.62 -3.911 +candidate_21883244 chr16 96178942 96178982 AAAACAAAAGCATGCTTTGGCTTATGGTTGTTGGCATTAA 0.35 1 -49.249 -313.9 -0.853 41.71 -2.546 +candidate_22483415 chr16 96191713 96191753 AAAACAACAAAATCTTAAAGCACTCATAGTGAGGTGGGTT 0.35 0 -47.606 -309.9 -0.846 40.25 -1.909 +candidate_22556001 chr16 97101262 97101302 AAAACAACACCGTGACACTCTTGCCTCACATTCTACAAAC 0.425 0 -50.796 -319.2 -0.865 43.13 -0.822 +candidate_21902275 chr16 97126580 97126620 AAAACAAAAGGTTTTACTATTGTTCACGGGGATGGATGGA 0.375 0 -48.437 -309.8 -0.843 41.43 -1.988 +candidate_22200544 chr16 97127845 97127885 AAAACAAACTGCTGAACTACCCAATAAGATCCTGCCACCA 0.425 0 -50.457 -312.1 -0.844 43.85 0.584 +candidate_21823349 chr16 97153091 97153131 AAAACAAAACCCCTAAGACTCCCCAGCTGTGCCCATATTA 0.45 0 -50.849 -309.7 -0.835 44.86 0.584 +candidate_22491482 chr16 97160493 97160533 AAAACAACAAAGTGCTGATCAAAAGCAGAAACACGGGGTC 0.425 0 -51.489 -319.8 -0.865 43.9 -0.929 +candidate_22300923 chr16 97165790 97165830 AAAACAAAGGCTGCAGACCATCTCTGACCTGCCAAACCCT 0.5 0 -53.878 -315.8 -0.844 47.94 -2.142 +candidate_22481196 chr16 97166331 97166371 AAAACAACAAAAGACATACATACACTCCCATTTCCCACAG 0.375 1 -47.904 -311.5 -0.85 40.49 1.684 +candidate_22242413 chr16 97176240 97176280 AAAACAAAGAGAAAATGAAGAAGAGGGAGGGAGGGAGGAA 0.425 678 -49.272 -307.1 -0.831 43.14 0.484 diff --git a/test_data/test.hush.fa b/test_data/test.hush.fa new file mode 100644 index 00000000..92d9d961 --- /dev/null +++ b/test_data/test.hush.fa @@ -0,0 +1,1000 @@ +>candidate_21654043 pos=16:11114621-11114661 +AAAACAAAACAAAACAAAACACTGCCCTCATCTCAAGTCC, 71 +>candidate_21658299 pos=16:22131287-22131327 +AAAACAAAACAAAACAAAACCCCAGCCAACCAAGCCTCAC, 383 +>candidate_21666318 pos=16:31196747-31196787 +AAAACAAAACAAAACAAACAAAAGTATCACCCTATCGCCC, 50 +>candidate_21670946 pos=16:68188874-68188914 +AAAACAAAACAAAACAAACCGAAAGTACCTGGACATACGA, 50 +>candidate_21676743 pos=16:90188443-90188483 +AAAACAAAACAAAACAACAACAACAAACTCAGCTAGCTCC, 480 +>candidate_21685155 pos=16:14129896-14129936 +AAAACAAAACAAAACACCATGAGGCCTTAGGCATGGGTTC, 2 +>candidate_21686495 pos=16:11114626-11114666 +AAAACAAAACAAAACACTGCCCTCATCTCAAGTCCCCAAA, 4 +>candidate_21686514 pos=16:81179833-81179873 +AAAACAAAACAAAACACTGGAAGCTTCTAAGTGACAGAGG, 1 +>candidate_21686674 pos=16:9163163-9163203 +AAAACAAAACAAAACACTTGAGGCAGGGAGATAGCTTAGT, 10 +>candidate_21687718 pos=16:70191486-70191526 +AAAACAAAACAAAACAGAACCGCACAGTGGAGGAGCAATA, 17 +>candidate_21696099 pos=16:22131292-22131332 +AAAACAAAACAAAACCCCAGCCAACCAAGCCTCACAGCCC, 11 +>candidate_21696605 pos=16:76195412-76195452 +AAAACAAAACAAAACCCTCTAAGCTTCTGTTCTTTTCCTC, 2 +>candidate_21696680 pos=16:23161159-23161199 +AAAACAAAACAAAACCCTGATCTTGAAAGCCAAGAGGTGA, 4 +>candidate_21696763 pos=16:33141995-33142035 +AAAACAAAACAAAACCCTGTTGGTTTTCCGACTTAGCAGG, 1 +>candidate_21696985 pos=16:15154698-15154738 +AAAACAAAACAAAACCGTGTTGTAGATGTTCCTGGAGAAA, 0 +>candidate_21698710 pos=16:73144761-73144801 +AAAACAAAACAAAACGGCAAATCCTAACTATGGAGTGGAT, 3 +>candidate_21699937 pos=16:90136408-90136448 +AAAACAAAACAAAACTCAATTAGCCACAGAGCACCAAGAG, 3 +>candidate_21700882 pos=16:43126383-43126423 +AAAACAAAACAAAACTGCTTAACACCTTGCCAGGCGCATG, 0 +>candidate_21704015 pos=16:47181492-47181532 +AAAACAAAACAAAAGAGGGCTCTGAGGTCAGTTGCTATGA, 4 +>candidate_21712832 pos=16:20146964-20147004 +AAAACAAAACAAAATTGTAAGTTGGAGGCAAGAGCTGTGT, 1 +>candidate_21717478 pos=16:31196752-31196792 +AAAACAAAACAAACAAAAGTATCACCCTATCGCCCTAGGT, 1 +>candidate_21732049 pos=16:68188879-68188919 +AAAACAAAACAAACCGAAAGTACCTGGACATACGAACCTT, 0 +>candidate_21732995 pos=16:48174889-48174929 +AAAACAAAACAAACTCAAGATTCTGCTTGAGTGACAGGGC, 0 +>candidate_21734070 pos=16:6153316-6153356 +AAAACAAAACAAAGAAACTCCATCTTTGGGTCTAGTCATG, 2 +>candidate_21734516 pos=16:85140354-85140394 +AAAACAAAACAAAGAAGAAGGATAGAAGGAACCAGAGAGA, 276 +>candidate_21735207 pos=16:5178254-5178294 +AAAACAAAACAAAGAGCTAGGCACTCGGGAGGTTGAGGCA, 10 +>candidate_21738820 pos=16:11141085-11141125 +AAAACAAAACAAAGGCTAGAGAGATGGCTCAGCAGTTAAG, 1201 +>candidate_21748103 pos=16:45181671-45181711 +AAAACAAAACAACAACAAAACCCACACAATGGATGTGATG, 26 +>candidate_21749831 pos=16:90188448-90188488 +AAAACAAAACAACAACAACAAACTCAGCTAGCTCCCATTA, 12 +>candidate_21753987 pos=16:27162495-27162535 +AAAACAAAACAACAGAAAGCTCACATACACGTGGAAGCCG, 1097 +>candidate_21755149 pos=16:30168215-30168255 +AAAACAAAACAACCAAACAACAAGGTGTCTCTTTGCCCTA, 5 +>candidate_21756048 pos=16:16119405-16119445 +AAAACAAAACAACCCAACCATGAACATAGACTCAGACCCT, 2 +>candidate_21758248 pos=16:33187988-33188028 +AAAACAAAACAACTCGTGGTCTCCTTTTCTTGGCTTCTCC, 1 +>candidate_21759100 pos=16:36139573-36139613 +AAAACAAAACAAGAAAACCCCATGCTTCAGATAGCTAGGC, 4 +>candidate_21759804 pos=16:50168025-50168065 +AAAACAAAACAAGAACAACTTCCTGCACATCTTTGCTCTC, 1 +>candidate_21761043 pos=16:9183788-9183828 +AAAACAAAACAAGACAAGACAAGACAGGACAGGACAGGAC, 1094 +>candidate_21774421 pos=16:82180535-82180575 +AAAACAAAACACAGACTCTCCCTCTCCCAGTAGCCATCAT, 17 +>candidate_21775575 pos=16:4115534-4115574 +AAAACAAAACACATTCCCAGGCTGGATTTGGCTCTTGGCC, 0 +>candidate_21777113 pos=16:14129901-14129941 +AAAACAAAACACCATGAGGCCTTAGGCATGGGTTCACTGG, 0 +>candidate_21778714 pos=16:50167929-50167969 +AAAACAAAACACCTCCCTAGGGCTAGTGCTCTAGCTAAGT, 0 +>candidate_21778745 pos=16:85151414-85151454 +AAAACAAAACACCTCTCCTAGACCAGAGACTAGGTGGTGC, 0 +>candidate_21779002 pos=16:16185138-16185178 +AAAACAAAACACCTTCCTCTCAACACCTCATGGTACCTTC, 1380 +>candidate_21780635 pos=16:11114631-11114671 +AAAACAAAACACTGCCCTCATCTCAAGTCCCCAAACAACT, 0 +>candidate_21780699 pos=16:81179838-81179878 +AAAACAAAACACTGGAAGCTTCTAAGTGACAGAGGATACA, 0 +>candidate_21781230 pos=16:9163168-9163208 +AAAACAAAACACTTGAGGCAGGGAGATAGCTTAGTTGGTA, 13 +>candidate_21784795 pos=16:70191491-70191531 +AAAACAAAACAGAACCGCACAGTGGAGGAGCAATACCATT, 2 +>candidate_21785278 pos=16:96178155-96178195 +AAAACAAAACAGAAGGCCACAAGGAAAAGGCTAACAGCCT, 0 +>candidate_21785540 pos=16:88192867-88192907 +AAAACAAAACAGAATAGCAGTTAGGCGGTAGGAGGGAGAA, 1 +>candidate_21790463 pos=16:73187251-73187291 +AAAACAAAACAGGAAGGGAATGACTGGAGCCATTCAAGAC, 0 +>candidate_21791592 pos=16:61181111-61181151 +AAAACAAAACAGGGAGGAGATGCCTTGGGTCCTGGAAATG, 0 +>candidate_21792153 pos=16:20134652-20134692 +AAAACAAAACAGGTCCTTAGAGGCAAGAACTACTGTAGAG, 5 +>candidate_21792914 pos=16:22154266-22154306 +AAAACAAAACAGTATAAGTAGCAGCCAAACAAAACCACCA, 3 +>candidate_21793507 pos=16:11160012-11160052 +AAAACAAAACAGTGCCAGTGCACTGGTGCACGACTTTAGT, 0 +>candidate_21795805 pos=16:14150563-14150603 +AAAACAAAACATACAATCTAAGTGAGTCCAAGTCTCTGAC, 0 +>candidate_21797204 pos=16:6123369-6123409 +AAAACAAAACATCACAGAACCTGGCAGATGGCTTCCTATG, 0 +>candidate_21798346 pos=16:83195310-83195350 +AAAACAAAACATGAAATATGGTGACCAGAGTAAAGGGGAG, 0 +>candidate_21806808 pos=16:36186937-36186977 +AAAACAAAACCAAACAAAACCAACAGAAATCCACTGGGTC, 147 +>candidate_21808115 pos=16:44115256-44115296 +AAAACAAAACCAAACCCTATACATAGCCAGATGGTATGAA, 0 +>candidate_21808347 pos=16:39121119-39121159 +AAAACAAAACCAAACTTCCAGCTGTTCAAGTCGTCTTGTG, 1 +>candidate_21814235 pos=16:91158849-91158889 +AAAACAAAACCACTGACTCACCAAGATAGACTTGGGTGGA, 14 +>candidate_21814624 pos=16:18106422-18106462 +AAAACAAAACCAGAAAGAAGCCACATAGAATGTTGGGCAT, 0 +>candidate_21815172 pos=16:53106595-53106635 +AAAACAAAACCAGAGATTATTCAGTTGTCTAATGGGAACC, 0 +>candidate_21815808 pos=16:22192173-22192213 +AAAACAAAACCAGGACAGTGTGTTACCTCCAAACATTAGC, 1 +>candidate_21817435 pos=16:6147636-6147676 +AAAACAAAACCATGCAGCGGATGGATTCTGGGGAATGACA, 1 +>candidate_21822694 pos=16:22131297-22131337 +AAAACAAAACCCCAGCCAACCAAGCCTCACAGCCCTCTTT, 0 +>candidate_21822783 pos=16:41170402-41170442 +AAAACAAAACCCCATAGGTTTAAATAGCATTGTTGGGGTT, 0 +>candidate_21823349 pos=16:97153091-97153131 +AAAACAAAACCCCTAAGACTCCCCAGCTGTGCCCATATTA, 0 +>candidate_21823586 pos=16:6111442-6111482 +AAAACAAAACCCCTTAAATTGGAGTGCACCCCTTCACGGG, 0 +>candidate_21824607 pos=16:76195417-76195457 +AAAACAAAACCCTCTAAGCTTCTGTTCTTTTCCTCCTGGT, 0 +>candidate_21824874 pos=16:23161164-23161204 +AAAACAAAACCCTGATCTTGAAAGCCAAGAGGTGATTGGA, 0 +>candidate_21825189 pos=16:33142000-33142040 +AAAACAAAACCCTGTTGGTTTTCCGACTTAGCAGGAGTCA, 23 +>candidate_21826337 pos=16:15154703-15154743 +AAAACAAAACCGTGTTGTAGATGTTCCTGGAGAAAGAAAT, 0 +>candidate_21829358 pos=16:38192572-38192612 +AAAACAAAACCTGGCTAATTTAGTACAGTGCTTTGTCCTC, 0 +>candidate_21833371 pos=16:69120689-69120729 +AAAACAAAACGATGTAGTGTATCTCAGGGTAGACATGGTA, 0 +>candidate_21834136 pos=16:90170058-90170098 +AAAACAAAACGGAGGAATAAATAGCCGCTGTCTCATAGCA, 0 +>candidate_21834208 pos=16:73144766-73144806 +AAAACAAAACGGCAAATCCTAACTATGGAGTGGATCCTTT, 0 +>candidate_21834785 pos=16:27141570-27141610 +AAAACAAAACGTATGAACCCAGAATGAGTAGACAACAGGA, 25 +>candidate_21838028 pos=16:4109470-4109510 +AAAACAAAACTAATCCCCAACTCTCTTTCCCTGATCAAAT, 0 +>candidate_21838265 pos=16:70179074-70179114 +AAAACAAAACTACAAAATCATGCCGAGGAAAGACAGTGAA, 1 +>candidate_21838416 pos=16:31102444-31102484 +AAAACAAAACTACACAACACGGAAGATATTCTCTGTAGTG, 1 +>candidate_21839431 pos=16:24135799-24135839 +AAAACAAAACTAGAGGTTCACTGGGAGGACTAGCCAAGCT, 0 +>candidate_21841895 pos=16:90136413-90136453 +AAAACAAAACTCAATTAGCCACAGAGCACCAAGAGGACAC, 0 +>candidate_21842556 pos=16:68125708-68125748 +AAAACAAAACTCATCACAATTGTAAGCAGCCACTTGAGTT, 5 +>candidate_21842776 pos=16:14112129-14112169 +AAAACAAAACTCCAAACCCAAACAACCAAAGCACCAAAGG, 64 +>candidate_21844822 pos=16:40101009-40101049 +AAAACAAAACTCTTGTGACAACACACATGAAGTATCCACA, 0 +>candidate_21846752 pos=16:94180536-94180576 +AAAACAAAACTGCATGTCATCCAGAGGCCAGAGAGCCTAG, 0 +>candidate_21847087 pos=16:43126388-43126428 +AAAACAAAACTGCTTAACACCTTGCCAGGCGCATGGATCC, 1 +>candidate_21848800 pos=16:84137050-84137090 +AAAACAAAACTGTGATGTATAGTTGTGAAAGGGGACAGCT, 0 +>candidate_21849939 pos=16:90133192-90133232 +AAAACAAAACTTACCATAGCTAGAGTGATTCACAAACCCC, 0 +>candidate_21851787 pos=16:14185388-14185428 +AAAACAAAACTTGGTTATGTGTTCCAGACAGAAGAGAACT, 0 +>candidate_21852077 pos=16:32162767-32162807 +AAAACAAAACTTTAAAAGGGTGGGAGGCAGAAGAGAACCC, 0 +>candidate_21852860 pos=16:63108540-63108580 +AAAACAAAACTTTGGTGGCTGGTAATGTAGATCAATGTTG, 1 +>candidate_21856056 pos=16:17181427-17181467 +AAAACAAAAGAAAACACAGAAGTAGCCCATCTCTTTGAGA, 3 +>candidate_21858474 pos=16:22172199-22172239 +AAAACAAAAGAAACTGGAGGATGATGGAGCAATGCCTTTA, 2 +>candidate_21858525 pos=16:29165094-29165134 +AAAACAAAAGAAACTTTCAATGCAAGCCAGATGACCTGAT, 0 +>candidate_21859959 pos=16:50118068-50118108 +AAAACAAAAGAAATATCCAGTGGCCAAAACCAGAACCAGG, 1 +>candidate_21863612 pos=16:17180243-17180283 +AAAACAAAAGAAGTGAAGGCAGATCTTTGTGAGTTGAAGG, 3 +>candidate_21864202 pos=16:84196585-84196625 +AAAACAAAAGAATACACTGTCTTCTCAGTACCAAAAGGTG, 1010 +>candidate_21864435 pos=16:8132196-8132236 +AAAACAAAAGAATATAACTTCTCAGCACCTCATGGAACCT, 753 +>candidate_21866061 pos=16:42197679-42197719 +AAAACAAAAGAATGGAGAGACTGCAAACATACTCCACTTT, 0 +>candidate_21866445 pos=16:80127300-80127340 +AAAACAAAAGAATTCCATTCCTAATCATTCCCCAAAGGCT, 1 +>candidate_21868748 pos=16:96107225-96107265 +AAAACAAAAGACCAGGGATGGTGGCATAGCTCAGTAAAGG, 3 +>candidate_21868751 pos=16:44165904-44165944 +AAAACAAAAGACCAGGTGACCAGCAATGTGATTAGAAAAG, 0 +>candidate_21871569 pos=16:24108671-24108711 +AAAACAAAAGAGCACTCCTTGCTCAGGTATTTACCTGTTG, 0 +>candidate_21872058 pos=16:17195497-17195537 +AAAACAAAAGAGGAAGAAAGGAAGCCAGCAAGCAAGTCAG, 488 +>candidate_21872220 pos=16:14180132-14180172 +AAAACAAAAGAGGATAGTGGAAGAGTGTAGGGGACAGAAA, 1 +>candidate_21872467 pos=16:47181497-47181537 +AAAACAAAAGAGGGCTCTGAGGTCAGTTGCTATGAAAAGA, 11 +>candidate_21872626 pos=16:43122088-43122128 +AAAACAAAAGAGGTGAAAAGAAGTCTGCAGTCTAGCTGCC, 0 +>candidate_21874668 pos=16:6176861-6176901 +AAAACAAAAGATCTGCTAACATCCTCCCCTCCCCTCCCCT, 0 +>candidate_21875152 pos=16:18106130-18106170 +AAAACAAAAGATGGAGGAGGAGGAGGAGGAGGAGGAGGAG, 5371 +>candidate_21875178 pos=16:44178494-44178534 +AAAACAAAAGATGGCATCCCGTGACAGGTACCAGTTCTAT, 0 +>candidate_21875790 pos=16:78106632-78106672 +AAAACAAAAGATTCCAAAATAGGCCAAGCAGGTGCAACCA, 2 +>candidate_21875941 pos=16:66143845-66143885 +AAAACAAAAGATTGGAAATCCACAGTAATCCATGCCAGTA, 0 +>candidate_21875958 pos=16:43193506-43193546 +AAAACAAAAGATTGGGCTGCACTGTGTTCCTGTAAGTGGG, 0 +>candidate_21877901 pos=16:35139947-35139987 +AAAACAAAAGCAAAAGCAAAGCACGATGCTAATGTGAGAA, 1 +>candidate_21880075 pos=16:92131398-92131438 +AAAACAAAAGCAAGCAAACAACATCATCACCATCATCACC, 75 +>candidate_21880288 pos=16:68164199-68164239 +AAAACAAAAGCAAGGCTGTTGAACACCTAAGCCAACAGTA, 1 +>candidate_21881395 pos=16:39190074-39190114 +AAAACAAAAGCACTCTAAGCAGCTTAGGGAGGAAAGGAGT, 8 +>candidate_21882598 pos=16:20162935-20162975 +AAAACAAAAGCATAAAACCTCAGTCCTGTCATAGCCCATA, 0 +>candidate_21883244 pos=16:96178942-96178982 +AAAACAAAAGCATGCTTTGGCTTATGGTTGTTGGCATTAA, 1 +>candidate_21883970 pos=16:33164535-33164575 +AAAACAAAAGCCAACCTAAGGGTTGGAGAGATGGTCCAGT, 54 +>candidate_21884557 pos=16:65100610-65100650 +AAAACAAAAGCCAGCCCTGTTTCCCTGATCCTCAGTTTCC, 2 +>candidate_21884633 pos=16:5196409-5196449 +AAAACAAAAGCCAGGCATGATGGTACGTTGGAAGTTGGAG, 1 +>candidate_21884867 pos=16:73131946-73131986 +AAAACAAAAGCCATCGTCTTAAGGGTATTATGTGGAAATG, 0 +>candidate_21885172 pos=16:29179333-29179373 +AAAACAAAAGCCCACCTAGACCATCATCTACCATTTGTGT, 0 +>candidate_21887125 pos=16:51197616-51197656 +AAAACAAAAGCTACATGGCCGATGCTCTCTTCACATGTAG, 0 +>candidate_21888142 pos=16:57184506-57184546 +AAAACAAAAGCTGCAATAGGAGACTCTCTGCCAAGACTAA, 0 +>candidate_21888583 pos=16:8147690-8147730 +AAAACAAAAGCTGTGTGACATACTGTGGCCCACTGCAGCT, 13 +>candidate_21890845 pos=16:61173693-61173733 +AAAACAAAAGGAAGAAACACAAAACCTGTGGAGTTCATGT, 2 +>candidate_21890879 pos=16:12137774-12137814 +AAAACAAAAGGAAGAAGATTGATAGTGAGAGAGGAGTCTG, 0 +>candidate_21891758 pos=16:90196260-90196300 +AAAACAAAAGGACAAAGATTGACAGCATCCAAGGAGGGAA, 0 +>candidate_21892971 pos=16:25169626-25169666 +AAAACAAAAGGAGGAGGAAGAGAATTAAGAAATTGACAGG, 7 +>candidate_21893541 pos=16:96106024-96106064 +AAAACAAAAGGATACTTATGGGCTGGGGAGATGGCTCATT, 249 +>candidate_21894666 pos=16:19131189-19131229 +AAAACAAAAGGATATACCTTCTTCTCAGCACCTCATCCTA, 1029 +>candidate_21896771 pos=16:4154836-4154876 +AAAACAAAAGGCAACTTACCATATTTGGCACAGTGGTGAC, 0 +>candidate_21897548 pos=16:91199660-91199700 +AAAACAAAAGGCCACTCTCTCCCCTTCTCCAGCTTCTTTT, 0 +>candidate_21898022 pos=16:5142581-5142621 +AAAACAAAAGGCTAGCCTTGGATGTATAGCAAGACTGTCT, 2 +>candidate_21902275 pos=16:97126580-97126620 +AAAACAAAAGGTTTTACTATTGTTCACGGGGATGGATGGA, 0 +>candidate_21904481 pos=16:51138374-51138414 +AAAACAAAAGTAGGAAAGCATTTCATTGTGGAAGCTCTAG, 28 +>candidate_21904608 pos=16:11192920-11192960 +AAAACAAAAGTAGTCAGGTGAGATGTGAAATACCAACAGT, 0 +>candidate_21909049 pos=16:17189854-17189894 +AAAACAAAAGTGGTGAGGAAAGATGGCTCAACAGTTAAAA, 123 +>candidate_21909100 pos=16:22147477-22147517 +AAAACAAAAGTGTAAAGTGCTTGCCAGACACAGAGACTCA, 0 +>candidate_21911224 pos=16:21183507-21183547 +AAAACAAAAGTTGGTACCAGAAGTAGAGTATTGCTGTGAT, 617 +>candidate_21915805 pos=16:6147626-6147666 +AAAACAAAATAAAACAAAACCATGCAGCGGATGGATTCTG, 12 +>candidate_21920282 pos=16:32187546-32187586 +AAAACAAAATAAACAGAAAAGCAAGCATTCCACAAAGCCC, 8 +>candidate_21924434 pos=16:72152772-72152812 +AAAACAAAATAACCAGTACTTGTGACTTCCTGGCTTCCAT, 0 +>candidate_21925638 pos=16:24143294-24143334 +AAAACAAAATAAGATGGTGGTTTGCCTTAATGACAGGAAG, 0 +>candidate_21939090 pos=16:28155420-28155460 +AAAACAAAATATGCTCAGTGCAAACCTCAAGGGCAGGTCA, 0 +>candidate_21943614 pos=16:78146038-78146078 +AAAACAAAATCAAGACTACAGCAGGAAAATGGGTGGAGGT, 2 +>candidate_21945865 pos=16:28149023-28149063 +AAAACAAAATCAGGGGTGCTTTAATATCATGGTTGCAATC, 0 +>candidate_21951625 pos=16:91185437-91185477 +AAAACAAAATCTCAACCAAATCCTAGCCTACTGCCTTTTA, 1 +>candidate_21951703 pos=16:54143955-54143995 +AAAACAAAATCTCACAGCAAACCTGTCCTTCTCTTCTGAC, 0 +>candidate_21951872 pos=16:10129152-10129192 +AAAACAAAATCTCATGCAACCAAGTCAGGCCTCCAGCTGG, 2 +>candidate_21955055 pos=16:28167909-28167949 +AAAACAAAATGAAACAAAACTCCGGTATCTTTCCTGTCTC, 4 +>candidate_21956780 pos=16:91182411-91182451 +AAAACAAAATGAAGCCAGCTTTGAACACACTGTGTTGGCA, 0 +>candidate_21958297 pos=16:50115922-50115962 +AAAACAAAATGAGAAAGGCGTGGTTGAGCTAGCCTCCATA, 1 +>candidate_21959123 pos=16:17100947-17100987 +AAAACAAAATGAGTGTGTCTAACACTAGTAGAAAGCCCCA, 0 +>candidate_21961679 pos=16:83169237-83169277 +AAAACAAAATGCCTTCTATCCACCTTCAGAAGACTTCAGT, 0 +>candidate_21961983 pos=16:80154036-80154076 +AAAACAAAATGCTCACAGAGGTGAAGGTGATCTACACAAA, 0 +>candidate_21966751 pos=16:37129884-37129924 +AAAACAAAATGTCCGTGCTATTCTCATGTCTGTCAGTGGC, 0 +>candidate_21967395 pos=16:58168778-58168818 +AAAACAAAATGTGCCTTAGCACAGTGGGCAATTTAGTATA, 0 +>candidate_21968283 pos=16:18109528-18109568 +AAAACAAAATGTTCCTCTGGTTTTCCAACAGGCTGTGGGG, 0 +>candidate_21972372 pos=16:48194702-48194742 +AAAACAAAATTAGAGACAAGGACATGAGGTAAAATGGCCA, 1 +>candidate_21973007 pos=16:47167787-47167827 +AAAACAAAATTATAACACTGGGTCCTTATCCTGTGCTGCT, 0 +>candidate_21978114 pos=16:63152879-63152919 +AAAACAAAATTGAGGGACTCCAGAATACAGAAAGAGCTGC, 0 +>candidate_21979257 pos=16:20146969-20147009 +AAAACAAAATTGTAAGTTGGAGGCAAGAGCTGTGTTGTAA, 1 +>candidate_21979283 pos=16:75142524-75142564 +AAAACAAAATTGTACAGAAAGGAACTACTCAGAGCCATGC, 2 +>candidate_21982381 pos=16:41132040-41132080 +AAAACAAAATTTCTACCCACTACTCCCTGCAGTGACAGTT, 0 +>candidate_21982954 pos=16:86199584-86199624 +AAAACAAAATTTGCAAGCATCTGGAATGGCTGGTAAGTGC, 0 +>candidate_21983199 pos=16:19155514-19155554 +AAAACAAAATTTGGGTGGGAGGTGGGAAAGTTCTGGGAGA, 0 +>candidate_22007903 pos=16:87129728-87129768 +AAAACAAACAAAACACTCAGTTCATCGGGTAAAGTCTAGG, 0 +>candidate_22008965 pos=16:85166641-85166681 +AAAACAAACAAAACCAGAAACCAAACCCCTTTTACCTGTG, 4 +>candidate_22009936 pos=16:13198354-13198394 +AAAACAAACAAAACGGGCCAAGCAGAAACCTATCTGTAGC, 0 +>candidate_22012273 pos=16:31196757-31196797 +AAAACAAACAAAAGTATCACCCTATCGCCCTAGGTAGCCT, 0 +>candidate_22067700 pos=16:79178510-79178550 +AAAACAAACAAACAAACAACCTGTCTGCCTCTTCCCTCAA, 14 +>candidate_22070025 pos=16:95161906-95161946 +AAAACAAACAAACAAACAGGAGCACAGTCATAATATTCCC, 14 +>candidate_22070415 pos=16:60163443-60163483 +AAAACAAACAAACAAACATGGTCAGAATGCAGAGTTATGG, 4 +>candidate_22072895 pos=16:11187568-11187608 +AAAACAAACAAACAAAGATGAGCCTTTGAAGCCCTAGAAC, 2 +>candidate_22077731 pos=16:67178091-67178131 +AAAACAAACAAACAAGAACAACAAAATCCCAGCCAGATGG, 91 +>candidate_22077881 pos=16:15134201-15134241 +AAAACAAACAAACAAGACCTAAAACTGTCCTGTAACAGTG, 4 +>candidate_22080165 pos=16:12188710-12188750 +AAAACAAACAAACACAAAGCCTATCCATCCCCATGGGTCT, 2 +>candidate_22080497 pos=16:32111082-32111122 +AAAACAAACAAACACACACCAACCAGAAGCAGAATGTTTA, 21 +>candidate_22080830 pos=16:64121803-64121843 +AAAACAAACAAACACCATAAGAAGAGCCAGCCAGAATAGT, 0 +>candidate_22082335 pos=16:50179734-50179774 +AAAACAAACAAACAGCATGGTGACACATGTTTGTAGTCCC, 4 +>candidate_22082778 pos=16:25112695-25112735 +AAAACAAACAAACAGTCGAACAAACAAACCCCAATCATAC, 1066 +>candidate_22083540 pos=16:30140025-30140065 +AAAACAAACAAACATGGCCAAGTCTATCGTAGAAAATGCC, 0 +>candidate_22088458 pos=16:78160661-78160701 +AAAACAAACAAAGAAAAGAAACTGGCAAGGATGCAGGGAA, 21 +>candidate_22089455 pos=16:26154863-26154903 +AAAACAAACAAAGACACAGACAAACAGACAGAGAGACTGA, 1265 +>candidate_22090997 pos=16:51143275-51143315 +AAAACAAACAAAGTTAGTAAGGCACTTGTCAATTCCCATG, 0 +>candidate_22097738 pos=16:48156249-48156289 +AAAACAAACAACAAAAGAGAGAGCTGAAAGGGACTGTACA, 2 +>candidate_22102208 pos=16:28116722-28116762 +AAAACAAACAACATACACTTGATATTGTCAAGCAAGGCCG, 0 +>candidate_22107943 pos=16:17193782-17193822 +AAAACAAACAAGCAAACAAAACAACAACATCAGCACTGGC, 491 +>candidate_22108944 pos=16:90137828-90137868 +AAAACAAACAAGCAAAGACAACCCACAGGGCTGGTAATAC, 5 +>candidate_22111133 pos=16:17108267-17108307 +AAAACAAACAAGGAGCTGGAGAAATAGCTCAGAGGTTAAG, 1058 +>candidate_22111571 pos=16:76106687-76106727 +AAAACAAACAAGGTCATAGCTCAGGGCTGTTCTGCCCTAT, 0 +>candidate_22115072 pos=16:41106475-41106515 +AAAACAAACAATCTTAACTACTACCACTACCACCACCATC, 37 +>candidate_22117822 pos=16:45173818-45173858 +AAAACAAACACAAATCTTTATCTACCTCCCTGAGCAGCCA, 1 +>candidate_22120338 pos=16:5155136-5155176 +AAAACAAACACACTCAAGAAACTGTTCCACTCATGGAGAA, 0 +>candidate_22121522 pos=16:23101375-23101415 +AAAACAAACACATACAAACAACCAGTACAGTAGTGCCAGA, 1 +>candidate_22126700 pos=16:90130090-90130130 +AAAACAAACACTTCTTCCCTTTATTTGCTTTCTCCAGCAT, 10 +>candidate_22128391 pos=16:66105689-66105729 +AAAACAAACAGAAAGGAAAGATTCTGGAAGAGGCACAGGA, 6 +>candidate_22129434 pos=16:12190394-12190434 +AAAACAAACAGAAGGAAAAGAGCCAAGCGAAGGCATAAGA, 68 +>candidate_22132000 pos=16:75198974-75199014 +AAAACAAACAGAGTGTGACATGTGTCGATTTCAGACAAAA, 0 +>candidate_22133710 pos=16:87137068-87137108 +AAAACAAACAGCAGTATCCAGATCAGCTGCATCCCTCCCA, 0 +>candidate_22133726 pos=16:96130849-96130889 +AAAACAAACAGCAGTGGCTACCACACAGTCATAGACCTGA, 4 +>candidate_22134530 pos=16:13118550-13118590 +AAAACAAACAGCTAGAAGTCAGATTGGGGATCCAAGCTGG, 52 +>candidate_22134652 pos=16:57199201-57199241 +AAAACAAACAGCTCGAGAGAGCACTCCTCGTCCCCAGTGC, 0 +>candidate_22135831 pos=16:73178578-73178618 +AAAACAAACAGGATATTGAATGCCATGAAGGAGGCTGTTC, 0 +>candidate_22136880 pos=16:73124496-73124536 +AAAACAAACAGGCTTCTGGATAGAGGAAGAGGTGTGGAGA, 0 +>candidate_22137318 pos=16:66107612-66107652 +AAAACAAACAGGGTCAAGTTGGTTCAACACTTGTGTTTTA, 0 +>candidate_22138543 pos=16:10153026-10153066 +AAAACAAACAGTATGATGGTCTAAGTTGGGCCATAGACAC, 5 +>candidate_22139014 pos=16:66135997-66136037 +AAAACAAACAGTGCAACTTGAGATTCTATGCCAACAGAGA, 0 +>candidate_22139245 pos=16:30109118-30109158 +AAAACAAACAGTGTGCTTTGCAAGGATGCAGTCATACTTG, 0 +>candidate_22140417 pos=16:42198376-42198416 +AAAACAAACATAACAATGCAATGGAATCCAGCTTTGCTTC, 0 +>candidate_22142541 pos=16:83147797-83147837 +AAAACAAACATATCTAGGCAAGACTAACCAGTGGCCACAG, 0 +>candidate_22143830 pos=16:74196682-74196722 +AAAACAAACATCCCCAAAGGCTTTGATATCCCATTCAGCA, 0 +>candidate_22143879 pos=16:68111670-68111710 +AAAACAAACATCCGTGTTGACAGCCCACTATTTCACAGAA, 0 +>candidate_22144385 pos=16:46108727-46108767 +AAAACAAACATCTGTGCTCAGGGGCTGCTGTAAGTGGTTC, 0 +>candidate_22153094 pos=16:32194021-32194061 +AAAACAAACCAAACAAAAGGCAGCACTGGTTGCTCTTCCA, 25 +>candidate_22154498 pos=16:63139745-63139785 +AAAACAAACCAAAGGAGACAAGCTTAGAATGTAGTAGACA, 0 +>candidate_22155674 pos=16:34122313-34122353 +AAAACAAACCAACAATCGTAACTAGGAGGGAAAACGGCAG, 0 +>candidate_22155947 pos=16:44159950-44159990 +AAAACAAACCAACATCCTGCTTTCACATTGAAGGGCAGAG, 0 +>candidate_22156764 pos=16:29182366-29182406 +AAAACAAACCAACTCATCCTAACACAGGGTTTCCCCTTTT, 254 +>candidate_22157299 pos=16:50159646-50159686 +AAAACAAACCAAGCATCCATGGGTGGGGAGTGAGTAAGAA, 0 +>candidate_22158341 pos=16:50123922-50123962 +AAAACAAACCAATTAAGCAGGTGAATATTGGCTGGGCTGA, 0 +>candidate_22159085 pos=16:27143471-27143511 +AAAACAAACCACAGCAGAAAATAGAAGGGATGAAAAGAAG, 8 +>candidate_22160134 pos=16:88124329-88124369 +AAAACAAACCACTCTCACCCCAAGAAAGCAAGACACAAAA, 1 +>candidate_22161492 pos=16:90147842-90147882 +AAAACAAACCAGCAGGGTAACAGTCTTTAGCTAATTTGTG, 0 +>candidate_22162118 pos=16:44151172-44151212 +AAAACAAACCAGGGAGTTGCTTCTGGGGTCCAGCTTTGAG, 0 +>candidate_22162200 pos=16:11163816-11163856 +AAAACAAACCAGGGTCTCAAATAGCCCAGCTTGGCTATGA, 3 +>candidate_22163643 pos=16:57158167-57158207 +AAAACAAACCATCTGGCACAATTAACTGACTGTACTTATC, 0 +>candidate_22164411 pos=16:82101203-82101243 +AAAACAAACCATTGAAACACTGATGAACCAAATAGGGGAA, 1 +>candidate_22165988 pos=16:63157019-63157059 +AAAACAAACCCAATCAAGACCCCTAAATGGTAGCATTTCT, 13 +>candidate_22167297 pos=16:88195353-88195393 +AAAACAAACCCAGTGATTGGCATGGCTCGAAATGTTTTCT, 0 +>candidate_22167603 pos=16:49183383-49183423 +AAAACAAACCCATGATCCAGACAGGCTCTGTGCAGATGCA, 0 +>candidate_22168403 pos=16:92162192-92162232 +AAAACAAACCCCAGATGCATGCCCATAGGTCAATCAGATT, 5 +>candidate_22168417 pos=16:57136534-57136574 +AAAACAAACCCCAGCCAAGTACAGTAGTGACAGTTCCTTG, 0 +>candidate_22168459 pos=16:74173913-74173953 +AAAACAAACCCCAGGCACATTCCTTATAGCCGTGTTATGC, 0 +>candidate_22168537 pos=16:11170884-11170924 +AAAACAAACCCCATCCCACCTCAGCTTCATTACTGCACTT, 0 +>candidate_22169674 pos=16:48189398-48189438 +AAAACAAACCCGGGTATGCCCCTTAGTTAAAACATTCCTT, 268 +>candidate_22169694 pos=16:16192234-16192274 +AAAACAAACCCGGTATGCCCCATAGTTAAAGCATTCCTGG, 254 +>candidate_22169998 pos=16:9169681-9169721 +AAAACAAACCCTACCTTAATGGGAGATATCACAGACTGGG, 1 +>candidate_22170395 pos=16:45154949-45154989 +AAAACAAACCCTCCCTTCCTTAACTGAAGTTTCCTAGCTC, 1 +>candidate_22171219 pos=16:11135198-11135238 +AAAACAAACCCTTCCCTCCCCAAGTAGCTTTTGTTCATGT, 1027 +>candidate_22171832 pos=16:68188884-68188924 +AAAACAAACCGAAAGTACCTGGACATACGAACCTTTCTAT, 0 +>candidate_22174961 pos=16:91126021-91126061 +AAAACAAACCTCCACAGAGCTTACTCAATTCTCTGAAGGA, 0 +>candidate_22175427 pos=16:92181887-92181927 +AAAACAAACCTCTCATCAGGATGGAAAAGTACCAACCTGT, 46 +>candidate_22179958 pos=16:5111686-5111726 +AAAACAAACGAAACACCATTGCTGGGTGCCAGGAGAGGGA, 0 +>candidate_22185338 pos=16:65122594-65122634 +AAAACAAACTAAACCCATAGACAACTGTATTGCCTCCTCC, 1 +>candidate_22185583 pos=16:8163848-8163888 +AAAACAAACTAAAGGAGAGTAAAGAAGAGTCACCAACCCT, 0 +>candidate_22188201 pos=16:55133103-55133143 +AAAACAAACTACATGCCAGGAGTTTCCTTTTCCTCTTGAG, 0 +>candidate_22188735 pos=16:81153500-81153540 +AAAACAAACTACTGCAGTCACTCAGGAAATTGTTGAGAAT, 0 +>candidate_22190073 pos=16:13184132-13184172 +AAAACAAACTAGGTGGGAAAGAGTTTACTTTGAGTGGTAG, 2 +>candidate_22192227 pos=16:27164290-27164330 +AAAACAAACTCAAACAAATCAGTAGCCTTCCTCTACTCAA, 1220 +>candidate_22192745 pos=16:48174894-48174934 +AAAACAAACTCAAGATTCTGCTTGAGTGACAGGGCCTTCA, 0 +>candidate_22193410 pos=16:40142209-40142249 +AAAACAAACTCACTATCAGAAATTGCCCAGCCTAGCCTAA, 0 +>candidate_22193752 pos=16:43152789-43152829 +AAAACAAACTCAGCCAATGTTTGGAGGTTCCTCGTCTCAT, 10 +>candidate_22193843 pos=16:90164453-90164493 +AAAACAAACTCAGGACTTTGTGAGCATCCATTATAGCTCA, 0 +>candidate_22195602 pos=16:64101875-64101915 +AAAACAAACTCCTCTGTCCCAGGCTAATGGTTTATTTGTC, 0 +>candidate_22196342 pos=16:18179921-18179961 +AAAACAAACTCTATGATCTGCCTGGTTACCCTGGCCAAGC, 0 +>candidate_22197324 pos=16:11181750-11181790 +AAAACAAACTCTTCCTCCCATTCTACTAAGGACTGCTAGG, 0 +>candidate_22197538 pos=16:7145407-7145447 +AAAACAAACTCTTTAGAGCTGGTGAATGCTTGTTCTCAGT, 0 +>candidate_22198662 pos=16:24108652-24108692 +AAAACAAACTGACAAACAGAAAACAAAAGAGCACTCCTTG, 26 +>candidate_22199438 pos=16:84113940-84113980 +AAAACAAACTGATACACGTGCAAAAGAGTGAATTTCCCCA, 0 +>candidate_22199459 pos=16:39138516-39138556 +AAAACAAACTGATACTTGTCCACACAGTCTCTGATAGTAC, 0 +>candidate_22200544 pos=16:97127845-97127885 +AAAACAAACTGCTGAACTACCCAATAAGATCCTGCCACCA, 0 +>candidate_22200957 pos=16:31174384-31174424 +AAAACAAACTGGACAGGCAGTGACAGACTCCCAGAGCTGA, 0 +>candidate_22201014 pos=16:75109753-75109793 +AAAACAAACTGGAGAAGCAAGTGGTGGAGTATCAGAGGTA, 0 +>candidate_22202360 pos=16:8100518-8100558 +AAAACAAACTGTATAGAGGGTTTGTCCCTGTGCAGAAGAC, 0 +>candidate_22202771 pos=16:66144420-66144460 +AAAACAAACTGTGACAAAGAGCCATCATTTCACGATCTTA, 0 +>candidate_22203018 pos=16:93137335-93137375 +AAAACAAACTGTGTACCAGCCCAGACCCTGCTGTGGAACC, 0 +>candidate_22205403 pos=16:57181778-57181818 +AAAACAAACTTCAATGTTCACACCACAAGATGCAGCAACA, 0 +>candidate_22206827 pos=16:20161423-20161463 +AAAACAAACTTGAAGGGAATTAAGTAGGCATGGAGGTTTT, 0 +>candidate_22207174 pos=16:81171525-81171565 +AAAACAAACTTGCAAAGTCATTGTGTTTGTTTGTGTTGGC, 1 +>candidate_22207831 pos=16:40187696-40187736 +AAAACAAACTTGTCACTAGTCCAGTCCAGGGACTCAGACT, 1 +>candidate_22208932 pos=16:62193639-62193679 +AAAACAAACTTTCAGAAGGAAGGCATAGTTCCTACAAAAG, 0 +>candidate_22213516 pos=16:42184208-42184248 +AAAACAAAGAAAACCTCCGAGTTTCTGTCTACCCAAAGAA, 0 +>candidate_22214148 pos=16:32110929-32110969 +AAAACAAAGAAAAGCAGAATGCAGGCCAAGCGGTGGCACT, 0 +>candidate_22214644 pos=16:10161150-10161190 +AAAACAAAGAAAATAATAATTCTGTGTCCTTGCCAGGGGC, 2 +>candidate_22218001 pos=16:6153321-6153361 +AAAACAAAGAAACTCCATCTTTGGGTCTAGTCATGCCCAC, 0 +>candidate_22220205 pos=16:51104997-51105037 +AAAACAAAGAAAGCAAAGGAGAATGACTGTGGGTTTTACT, 1 +>candidate_22221967 pos=16:78121594-78121634 +AAAACAAAGAAATCAACAGGCTATCACATCTTCCCTTTCT, 0 +>candidate_22226467 pos=16:85140359-85140399 +AAAACAAAGAAGAAGGATAGAAGGAACCAGAGAGATAAAG, 295 +>candidate_22230471 pos=16:48150618-48150658 +AAAACAAAGAATATTACCAAGGACCACTCCACTCTGTCTC, 0 +>candidate_22231264 pos=16:35100492-35100532 +AAAACAAAGAATGAATGAATTCAGGCATGGTGATTCACCC, 3 +>candidate_22231544 pos=16:62146595-62146635 +AAAACAAAGAATGGACAGCCATGCCACAATAATGGAAGAA, 0 +>candidate_22234415 pos=16:53153978-53154018 +AAAACAAAGACAACCACTGCATGTGGGCTGATGTGCCTTT, 0 +>candidate_22235188 pos=16:84110136-84110176 +AAAACAAAGACACAGATACTTAACTGGGTATACAAGTGCA, 1 +>candidate_22235294 pos=16:85110795-85110835 +AAAACAAAGACACATGCGTACACACATGGCCTCATTCAGA, 4 +>candidate_22235562 pos=16:66120355-66120395 +AAAACAAAGACACTGAGCTGGGAGAAAAGATTGCTCTCTT, 0 +>candidate_22237073 pos=16:95114060-95114100 +AAAACAAAGACATCATGAAATTTGCAGGCAATGGACAGAA, 1007 +>candidate_22238881 pos=16:91149318-91149358 +AAAACAAAGACCCAGAGAAGTTAAGTCATGCAAGGGTATA, 0 +>candidate_22240123 pos=16:58145273-58145313 +AAAACAAAGACTAACACCCTAGGGCGTTCTCCAACTTCCC, 0 +>candidate_22240135 pos=16:32114579-32114619 +AAAACAAAGACTAACCATCACATACGACCTGGATACCCTA, 0 +>candidate_22240291 pos=16:18162248-18162288 +AAAACAAAGACTACTTACATCCAGCCCCTCTGGAGCTCTG, 0 +>candidate_22242413 pos=16:97176240-97176280 +AAAACAAAGAGAAAATGAAGAAGAGGGAGGGAGGGAGGAA, 678 +>candidate_22242847 pos=16:41171621-41171661 +AAAACAAAGAGAAATGTTCCTACCTGGTAACACATAGGAC, 0 +>candidate_22243294 pos=16:91118707-91118747 +AAAACAAAGAGAAGCAGCACTGGGAGACAAGGTCACCAAT, 0 +>candidate_22244228 pos=16:6117975-6118015 +AAAACAAAGAGAGAAACACACAGAGAGAAACACAGAGAGA, 1283 +>candidate_22244542 pos=16:31144986-31145026 +AAAACAAAGAGAGAGGTGCAAGAGGGAGTGGGGAGGGGTC, 5 +>candidate_22245248 pos=16:90156432-90156472 +AAAACAAAGAGATCTGTCTTCCTCTGCCTCCCAAGTGCTG, 2400 +>candidate_22246691 pos=16:5178259-5178299 +AAAACAAAGAGCTAGGCACTCGGGAGGTTGAGGCAGGAAG, 15 +>candidate_22248005 pos=16:68163705-68163745 +AAAACAAAGAGGCCTTGACGATTCTATGGAACACACGTGA, 0 +>candidate_22249466 pos=16:53198620-53198660 +AAAACAAAGAGTCATTCAAGCTGAAGGGGAATTGGTAGGA, 0 +>candidate_22249903 pos=16:20170601-20170641 +AAAACAAAGAGTGTAATGAACCTCCATGTGCCAAATCAAT, 0 +>candidate_22250312 pos=16:3109155-3109195 +AAAACAAAGAGTTGGGCCGGGCGTGGTGGCACACACCTTT, 1059 +>candidate_22251468 pos=16:51149587-51149627 +AAAACAAAGATACAAGTAACACAATACAGACTGAGCTGGT, 434 +>candidate_22251480 pos=16:62192811-62192851 +AAAACAAAGATACAATGGTTGAGGATATGCCTCTGTGGAT, 1 +>candidate_22254279 pos=16:39105899-39105939 +AAAACAAAGATGAAGAAACACCCAGATCCAACTGGGGCCT, 0 +>candidate_22263227 pos=16:65100596-65100636 +AAAACAAAGCAAACAAAACAAAAGCCAGCCCTGTTTCCCT, 24 +>candidate_22264711 pos=16:96115374-96115414 +AAAACAAAGCAAAGCAAAATCAGCAGACAGTCTGTTTCCC, 5 +>candidate_22266827 pos=16:46140996-46141036 +AAAACAAAGCAACTTGGGTAGGAAAAGGTGTGTTTGGCTA, 302 +>candidate_22267124 pos=16:64124738-64124778 +AAAACAAAGCAAGACCCAACAGCTACAAGAAAACTGAAAT, 747 +>candidate_22267784 pos=16:93148087-93148127 +AAAACAAAGCAAGGCAAGGTCAAGAGGTAGCCTGGGAGAG, 0 +>candidate_22267986 pos=16:49132159-49132199 +AAAACAAAGCAAGTCTCCCTTGTCCAAGAAAAGAATGATC, 0 +>candidate_22270008 pos=16:37196041-37196081 +AAAACAAAGCACCCATATCATAAATCATTCTCTGGATCAC, 0 +>candidate_22270492 pos=16:68171225-68171265 +AAAACAAAGCACTGGAAGTCAAATCACGGGGTCTATACTG, 4 +>candidate_22270800 pos=16:57163111-57163151 +AAAACAAAGCAGAAACACTCTCTAGGAAGGGAATGCTTTT, 0 +>candidate_22272621 pos=16:78164887-78164927 +AAAACAAAGCAGGGCTGCCTTGGCTAGAAGGACAAGTGAG, 0 +>candidate_22274021 pos=16:18122906-18122946 +AAAACAAAGCATATTTGCACTCCCTGTGGGTGGCAGTGGC, 0 +>candidate_22274554 pos=16:4153705-4153745 +AAAACAAAGCATGAGAGAGGGAGGCAGGCAGTACATAAGC, 0 +>candidate_22274607 pos=16:25188474-25188514 +AAAACAAAGCATGATGTGTATGTGTGTGTGTGTGTGTGTG, 1445 +>candidate_22274960 pos=16:18191168-18191208 +AAAACAAAGCATGTTATGAAATCCCAGAGAAGCCCATGGC, 0 +>candidate_22275089 pos=16:64170152-64170192 +AAAACAAAGCATTAGCAAGTGCAATAGCATTGCTACTAGA, 0 +>candidate_22276314 pos=16:55137295-55137335 +AAAACAAAGCCAAATCCTCTATTTTGTGAGAAGGGAAGGG, 0 +>candidate_22276407 pos=16:48163864-48163904 +AAAACAAAGCCAACAGAGAAGTCGTAGCCTCAACCCTCTA, 0 +>candidate_22277296 pos=16:15184133-15184173 +AAAACAAAGCCACTCCTAGGCTCCTTGCTATTTGTAGGAC, 0 +>candidate_22277386 pos=16:80198612-80198652 +AAAACAAAGCCAGAAAGTGAATTACTGACCCAAGATTCTA, 0 +>candidate_22278994 pos=16:48190339-48190379 +AAAACAAAGCCCAGAGAACTAGACGAAGAGCAAGCGTAGC, 0 +>candidate_22279207 pos=16:90183096-90183136 +AAAACAAAGCCCATTATCTTACACAGAGCAGTGCTGAGGC, 0 +>candidate_22279494 pos=16:92122139-92122179 +AAAACAAAGCCCCTGACTAATGAATTAAAGAGGAATGCAG, 1 +>candidate_22281771 pos=16:13160190-13160230 +AAAACAAAGCGAACAGAAATGTGCAGGTACTTTTGCGGCG, 0 +>candidate_22281774 pos=16:49153622-49153662 +AAAACAAAGCGAACCAAAAGCAGTGCTTGGATGGTGAGAC, 0 +>candidate_22283034 pos=16:49153168-49153208 +AAAACAAAGCTACAGAGTGAGAGTGGTAAGAAGATGTGTT, 0 +>candidate_22283133 pos=16:55104509-55104549 +AAAACAAAGCTACCTCCCTCACAGACATGCCCACAGGCTA, 8 +>candidate_22285544 pos=16:43157945-43157985 +AAAACAAAGCTGCCACAGCAATGTTAGTATCAGGAGACCT, 0 +>candidate_22285837 pos=16:47151351-47151391 +AAAACAAAGCTGGCAAACAATTTAGTTTGTAAAGTGGGTG, 1 +>candidate_22289175 pos=16:15136403-15136443 +AAAACAAAGGAAACCTGAAGTGTCCCTAGACATGACCTAA, 0 +>candidate_22291090 pos=16:31132942-31132982 +AAAACAAAGGAAGGAAGAAAGGAAAGAAAGGAGCGAGGGA, 1237 +>candidate_22292624 pos=16:54121626-54121666 +AAAACAAAGGACAGCAATAGGTGAAACTAGGTCACTAAGG, 0 +>candidate_22292665 pos=16:8111403-8111443 +AAAACAAAGGACAGGCTGCAACCAGCAACTCTGCTTGCTG, 0 +>candidate_22293865 pos=16:55185288-55185328 +AAAACAAAGGAGACCTACACTATACCATGCTTATAGATCA, 0 +>candidate_22294429 pos=16:31104483-31104523 +AAAACAAAGGAGCTAATTAAGCCAATGAGCAGCCTCCTCT, 0 +>candidate_22294609 pos=16:73178356-73178396 +AAAACAAAGGAGGAGAAGAAAAGGAAGAGGAGAAGGAGGA, 1202 +>candidate_22297174 pos=16:60175876-60175916 +AAAACAAAGGCAAGCAGGGATGTTTGTTCTAATTAAGCAT, 0 +>candidate_22297925 pos=16:46186219-46186259 +AAAACAAAGGCAGAGAGTCCAGATTTGCCTGGCCCAAAGA, 0 +>candidate_22298648 pos=16:24187087-24187127 +AAAACAAAGGCATCCTGGCCTGTTAGAAACTAAGTTTCAG, 0 +>candidate_22298997 pos=16:26100961-26101001 +AAAACAAAGGCCAAATCTCACAAAGCACCAAGTCAAGAAT, 0 +>candidate_22299683 pos=16:10168337-10168377 +AAAACAAAGGCCTAATCCATCAAAGTTCATAGTTCTGGGA, 387 +>candidate_22300372 pos=16:11141090-11141130 +AAAACAAAGGCTAGAGAGATGGCTCAGCAGTTAAGAGCAC, 1237 +>candidate_22300595 pos=16:42103309-42103349 +AAAACAAAGGCTCACTTTCTATAGCACCAACACTTGGATT, 1 +>candidate_22300923 pos=16:97165790-97165830 +AAAACAAAGGCTGCAGACCATCTCTGACCTGCCAAACCCT, 0 +>candidate_22300972 pos=16:31194128-31194168 +AAAACAAAGGCTGCTTGACCACAGGCACTACAATACTACC, 0 +>candidate_22302074 pos=16:5109235-5109275 +AAAACAAAGGGAACTGGGGTTGAAGAGATGGCTCAGTGGT, 1031 +>candidate_22302160 pos=16:90124634-90124674 +AAAACAAAGGGAAGCCCAGCAGCAAGGCAGCTGCATCTAA, 0 +>candidate_22302865 pos=16:13127182-13127222 +AAAACAAAGGGAGGGAGGAGGGGAGCGGAGAGGAGGGGAG, 1043 +>candidate_22305091 pos=16:15186089-15186129 +AAAACAAAGGGGTGGGAAACCCATCTCCCACCAGAGCTCG, 9 +>candidate_22305276 pos=16:12138525-12138565 +AAAACAAAGGGTACACAAAGTAAATTGTGTGTGTGTGTGT, 40 +>candidate_22306763 pos=16:54145774-54145814 +AAAACAAAGGTAGCAAATTCACCCAAGAGGAGTAGACAGC, 1469 +>candidate_22306792 pos=16:32126901-32126941 +AAAACAAAGGTAGCCTGCTCACCAACATTGGAAAATCGAG, 0 +>candidate_22307094 pos=16:13176077-13176117 +AAAACAAAGGTATGATCACACTATCCCAAGAAGGTTTTCT, 0 +>candidate_22307991 pos=16:34107515-34107555 +AAAACAAAGGTCTTCTCGGTGTATATCCTGTCCTTTTGGA, 0 +>candidate_22308271 pos=16:93102076-93102116 +AAAACAAAGGTGAGCAGGCTAATTCGGTGCCTGGAGCCAA, 0 +>candidate_22308782 pos=16:39186247-39186287 +AAAACAAAGGTGGTAAATGCTGGTGAAGGTGTGGCTAAAC, 1 +>candidate_22309502 pos=16:18197471-18197511 +AAAACAAAGGTTCCTCCTTTCAGATCCCCACAGGGTCTCC, 0 +>candidate_22309582 pos=16:77139315-77139355 +AAAACAAAGGTTCTTCTAAGTGGTAGTGGGACAGAAGGAA, 0 +>candidate_22311802 pos=16:72102985-72103025 +AAAACAAAGTAAATGTCATAAGTTCTCCTCCTCTTGTCCT, 2 +>candidate_22317162 pos=16:93153957-93153997 +AAAACAAAGTATGAAGGAGAAATGTTGGTGAGGGTTGCAT, 0 +>candidate_22322429 pos=16:10191280-10191320 +AAAACAAAGTCTCTGCTGGGCTTTCTTGAAATTTCCTTTA, 519 +>candidate_22322736 pos=16:70183950-70183990 +AAAACAAAGTCTGGGGTTTGGCACTACCACATCCTATTCT, 0 +>candidate_22324337 pos=16:86170469-86170509 +AAAACAAAGTGACTAGGATAGGGAAGGTTGGAACTTTTAT, 0 +>candidate_22325033 pos=16:18199206-18199246 +AAAACAAAGTGATGCTGAGGGCCCATGAGGAGGCTACAGT, 0 +>candidate_22325960 pos=16:88141120-88141160 +AAAACAAAGTGCTTCATCAAATGCAGGCACCGGCTGGATA, 0 +>candidate_22328152 pos=16:76113352-76113392 +AAAACAAAGTGTGGGGAGCCGCGCGGGTAATAACAAAGCA, 0 +>candidate_22331015 pos=16:26162478-26162518 +AAAACAAAGTTCCAAGGGGCCAATCCCTAGGCCAAAAGCA, 0 +>candidate_22334198 pos=16:75129428-75129468 +AAAACAAAGTTTGAGATTAAGCTCAAACCTTGCAGAGCTA, 0 +>candidate_22334282 pos=16:33149008-33149048 +AAAACAAAGTTTGCCACTCTTGGCATATCTAAGACTTTAG, 0 +>candidate_22337724 pos=16:96115203-96115243 +AAAACAAATAAAACACACATCTCGAAACTCCAATGGCGGG, 1 +>candidate_22342579 pos=16:44128322-44128362 +AAAACAAATAAACCTATGAGCTGGAGCAAGTGGGGCCGGA, 186 +>candidate_22344144 pos=16:15131264-15131304 +AAAACAAATAAATAAAACCAACTCCTGAATCCCCTTCCTG, 0 +>candidate_22348223 pos=16:60138660-60138700 +AAAACAAATAACAGTACATGCTGGCAAAGAGGTAGAGTAA, 232 +>candidate_22349222 pos=16:51186899-51186939 +AAAACAAATAACCGCATTAAAATATGGGGCTCAGAGCTAA, 1115 +>candidate_22349836 pos=16:39185937-39185977 +AAAACAAATAACTGAGCAGAGAGGAAGCCCACGGAGTGAG, 6 +>candidate_22350221 pos=16:76188356-76188396 +AAAACAAATAAGAAACTCACAAAGAGGAAGGAAGGGAGGG, 51 +>candidate_22354848 pos=16:6143948-6143988 +AAAACAAATAATGGGAAATGCTGGCAAGGGCTCAGGCAAA, 3 +>candidate_22355635 pos=16:60105525-60105565 +AAAACAAATAATTGGTTTTGAAGGCTCAGCCCTAAACATG, 1 +>candidate_22356305 pos=16:88124318-88124358 +AAAACAAATACAAAACAAACCACTCTCACCCCAAGAAAGC, 10 +>candidate_22357832 pos=16:20117628-20117668 +AAAACAAATACACAGTGTGCTTGTGGGATTAAAATGTCCC, 0 +>candidate_22358340 pos=16:75187595-75187635 +AAAACAAATACAGACTCTTGTAGCACAGCAGTAGAAACAG, 0 +>candidate_22359397 pos=16:72145410-72145450 +AAAACAAATACATGAATAAGTGGGTGGGGTGACACAATGT, 1 +>candidate_22361207 pos=16:6135546-6135586 +AAAACAAATACGAGATCAGCCTGTTGGTACACTGCCAATA, 0 +>candidate_22363266 pos=16:84123068-84123108 +AAAACAAATACTTTCTACAGTGAGGAAAATCCACAGAGGT, 0 +>candidate_22363675 pos=16:54122567-54122607 +AAAACAAATAGAAACAAACCCATCCAAGAGGAGTAGAAGG, 1049 +>candidate_22366619 pos=16:36101464-36101504 +AAAACAAATAGCCCCAAGAAGGAATGTGCAAAAGGCCTGA, 0 +>candidate_22369611 pos=16:14186124-14186164 +AAAACAAATAGTTTGCCCTGGTAAGAACCTGGTGTGGGTC, 0 +>candidate_22373867 pos=16:93179825-93179865 +AAAACAAATATCATTGCCTTGTAGGGCAGCTTCAGGTTCG, 0 +>candidate_22374476 pos=16:33181585-33181625 +AAAACAAATATCTAGCTGGGCCTGGTGATGCAGGCTGTAA, 10 +>candidate_22375839 pos=16:6136459-6136499 +AAAACAAATATGCTCCCAAATGGCTTGTGTGTTTATTACC, 0 +>candidate_22383821 pos=16:40125692-40125732 +AAAACAAATCAAGCAGAAAGCCCATGCGGATAAGAGCGGT, 0 +>candidate_22384493 pos=16:53191793-53191833 +AAAACAAATCAATCTGACATTAGGCAGTGTTCTGGGTTGA, 0 +>candidate_22385414 pos=16:76107708-76107748 +AAAACAAATCACATCGTATCACATCTCTCTGCCTAAACCA, 0 +>candidate_22385976 pos=16:88127352-88127392 +AAAACAAATCACTCACTCCATCCTAGAAGAGCAAACTGCC, 0 +>candidate_22388274 pos=16:41173653-41173693 +AAAACAAATCATAACCAGCTTTTCACAGGTTCAGAAGCTC, 0 +>candidate_22389140 pos=16:90101042-90101082 +AAAACAAATCATGAGCCCACCTTTGCAGTGTTACCTTACA, 0 +>candidate_22391255 pos=16:13108590-13108630 +AAAACAAATCCACTTGCAGCGGCTGATGTGAAGGGAGATT, 0 +>candidate_22392409 pos=16:45124376-45124416 +AAAACAAATCCCACTTTGGTGGCACATATGTGTCATCTCA, 3 +>candidate_22393590 pos=16:83170773-83170813 +AAAACAAATCCTACCTCCAGAGAAAGAGAGAGAGAGAGAT, 118 +>candidate_22399452 pos=16:86120245-86120285 +AAAACAAATCTGATCTGCATTTTGATGCTGTACCGCTAAC, 0 +>candidate_22402937 pos=16:87187631-87187671 +AAAACAAATCTTTGTGAGTTCAAGGCCTGCCCACTCTCCA, 214 +>candidate_22404908 pos=16:52134574-52134614 +AAAACAAATGAAAGCCCGAGCGAACTTGCCTCACGTAATC, 0 +>candidate_22406075 pos=16:60185472-60185512 +AAAACAAATGAACAATGATCTCTCCTATATGGTCACAAGG, 0 +>candidate_22406780 pos=16:94123970-94124010 +AAAACAAATGAAGAAATGCCCGGCCTTGGGGACAGAAGCC, 0 +>candidate_22409580 pos=16:15123716-15123756 +AAAACAAATGACAGTTCATGTTGGCAATCATAGAGGATAG, 13 +>candidate_22409669 pos=16:64127159-64127199 +AAAACAAATGACATCTCATATTGGTGAGGACGTGAAATAC, 69 +>candidate_22409934 pos=16:39186056-39186096 +AAAACAAATGACCCAATTAACAAATGGGCTATGGAGCTGA, 1084 +>candidate_22410844 pos=16:71175515-71175555 +AAAACAAATGACTTTACTGGCCCTGCCTACTTTTCTTATT, 0 +>candidate_22411499 pos=16:14145787-14145827 +AAAACAAATGAGATAAGAGAGAGGCTCAAAAGGCTGCAGT, 0 +>candidate_22412801 pos=16:66173972-66174012 +AAAACAAATGAGTTAAGCCATAAATGTCAGGCAAGCCTTT, 0 +>candidate_22414716 pos=16:6125809-6125849 +AAAACAAATGATTGGCATGTTCAGTGGAGGGCCTGTTGGT, 0 +>candidate_22416928 pos=16:55125756-55125796 +AAAACAAATGCATCAATCTAATGCTAGAAAGGAATCTGGC, 1 +>candidate_22420280 pos=16:94159288-94159328 +AAAACAAATGCTTCCTCCCTTAAGTTGCACAGCCTAGGAA, 2 +>candidate_22422286 pos=16:57100406-57100446 +AAAACAAATGGAGTCTCAAGGTACCCATAAATTGTGTCTT, 0 +>candidate_22423546 pos=16:41192808-41192848 +AAAACAAATGGCCCAATTTGTCATTGCTATACCTCATCAT, 0 +>candidate_22427785 pos=16:65176726-65176766 +AAAACAAATGTAGACCTGAGAACTTCATGTGAGAGATGGG, 0 +>candidate_22431224 pos=16:56124062-56124102 +AAAACAAATGTGCTTTAATGGCTAGTGTGACTTTTGCCCA, 0 +>candidate_22431606 pos=16:11140939-11140979 +AAAACAAATGTGGTGCACATCTTTACTCCAAGTACTCCGG, 24 +>candidate_22431610 pos=16:13150836-13150876 +AAAACAAATGTGGTGGCCATCAGCCCTGTCCTCAGTAGTC, 0 +>candidate_22432810 pos=16:10143517-10143557 +AAAACAAATGTTATCAGTCTGAAGGATAACATCCCTTTCC, 8 +>candidate_22439916 pos=16:90141470-90141510 +AAAACAAATTACTGGGGAAGAGCCAGGAGAATCATCCAAG, 0 +>candidate_22442846 pos=16:73115936-73115976 +AAAACAAATTATCTGGGTTTGGAGAGATGGTTCTGTGGTT, 551 +>candidate_22445629 pos=16:16131714-16131754 +AAAACAAATTCACACATTGTCTTTCCACGAATCCAGCCCT, 1055 +>candidate_22446077 pos=16:44104803-44104843 +AAAACAAATTCAGAGACTGACACGGTTCATGTCTGAGAAA, 1 +>candidate_22448911 pos=16:84178196-84178236 +AAAACAAATTCTACTGTCCTACTCACACACACACACACAC, 490 +>candidate_22451921 pos=16:13142802-13142842 +AAAACAAATTGAGGCAGGGAGCCACCGAATGACTTATTCC, 0 +>candidate_22454116 pos=16:6181586-6181626 +AAAACAAATTGGGCTACTGGGATGGCTCAGTGGGAAAGGC, 243 +>candidate_22455527 pos=16:12145387-12145427 +AAAACAAATTGTGTCAGAGTATCTGGCTAAGGGGTTCTGC, 0 +>candidate_22461655 pos=16:76185390-76185430 +AAAACAAATTTCTGGGGTGACACCTGCCTTCTTCCCTGTG, 0 +>candidate_22462363 pos=16:38165907-38165947 +AAAACAAATTTGAGGTGAATCCTGTTTTACAGTAGCAGCA, 0 +>candidate_22478627 pos=16:67150981-67151021 +AAAACAACAAAACAAGTAAACACTAGCATTCACTCACTGG, 0 +>candidate_22481196 pos=16:97166331-97166371 +AAAACAACAAAAGACATACATACACTCCCATTTCCCACAG, 1 +>candidate_22482990 pos=16:34149365-34149405 +AAAACAACAAAATATCATTGTCACCTCCTGCTCTAGATGT, 0 +>candidate_22483304 pos=16:14130104-14130144 +AAAACAACAAAATCCCCACAAAGCACTCTAGGGTGATGGT, 1 +>candidate_22483415 pos=16:96191713-96191753 +AAAACAACAAAATCTTAAAGCACTCATAGTGAGGTGGGTT, 0 +>candidate_22486781 pos=16:28140215-28140255 +AAAACAACAAACAATCAAAGCCCATCCCTCAACCAACCAA, 13 +>candidate_22487831 pos=16:20136212-20136252 +AAAACAACAAACCACTAAGGAAATTAGTGTTAGGGGTTCT, 1 +>candidate_22488479 pos=16:4169917-4169957 +AAAACAACAAACTACTTTCACCAGCATGTCATCCACTTTG, 0 +>candidate_22488840 pos=16:40123532-40123572 +AAAACAACAAACTTCGCTTAGGTGTCCTAAGCAAATGATT, 0 +>candidate_22489854 pos=16:15135210-15135250 +AAAACAACAAAGAGGGCATATTCTGAGGAGATTTGGGAAT, 0 +>candidate_22490642 pos=16:96113584-96113624 +AAAACAACAAAGCTTCATCCAGCATCCACAGCACCAGCAC, 0 +>candidate_22491482 pos=16:97160493-97160533 +AAAACAACAAAGTGCTGATCAAAAGCAGAAACACGGGGTC, 0 +>candidate_22494369 pos=16:15155435-15155475 +AAAACAACAAATTCTGCCATGCTTAGGGTTACAAATTGCT, 29 +>candidate_22501160 pos=16:45181676-45181716 +AAAACAACAACAAAACCCACACAATGGATGTGATGAGTTT, 3 +>candidate_22510637 pos=16:90188453-90188493 +AAAACAACAACAACAAACTCAGCTAGCTCCCATTAATAAG, 0 +>candidate_22513714 pos=16:92173690-92173730 +AAAACAACAACAACAACAAAACCCCAAGTCCCCAGCACCA, 148 +>candidate_22516171 pos=16:94158568-94158608 +AAAACAACAACAACAACAACAAAATACTGGTCCTCTCCTC, 144 +>candidate_22518786 pos=16:94100674-94100714 +AAAACAACAACAACAACAACAACAACCATGTTCTGCATCC, 666 +>candidate_22518902 pos=16:75105564-75105604 +AAAACAACAACAACAACAACAACAATCTCAGTGCATATCC, 485 +>candidate_22519056 pos=16:94128515-94128555 +AAAACAACAACAACAACAACAACATCATTACTGTGGGCCC, 251 +>candidate_22519488 pos=16:80166974-80167014 +AAAACAACAACAACAACAACACCTCTGTGATTACTGGAGA, 32 +>candidate_22519521 pos=16:32145524-32145564 +AAAACAACAACAACAACAACAGAAAGAAACTGGGCATGGT, 283 +>candidate_22519965 pos=16:96109738-96109778 +AAAACAACAACAACAACAAGAAGCTACTGATTATGGTGGC, 19 +>candidate_22520899 pos=16:38131343-38131383 +AAAACAACAACAACAACCAGTCCAGTGCAGAGACCAAAAC, 2 +>candidate_22522157 pos=16:6119212-6119252 +AAAACAACAACAACACCTGTTGTAAATAGACACAAGGCAA, 0 +>candidate_22522176 pos=16:75109734-75109774 +AAAACAACAACAACACTCCAAAACAAACTGGAGAAGCAAG, 7 +>candidate_22523023 pos=16:35115313-35115353 +AAAACAACAACAACCAAACCTACAAGAACAACAAAGGCAT, 1072 +>candidate_22525042 pos=16:9111319-9111359 +AAAACAACAACAATAACAGCAACAGCAGCAGCAGCAGCAA, 1165 +>candidate_22526849 pos=16:12172836-12172876 +AAAACAACAACAGACACACACAGCTGTGGTAGGGTAGCCA, 0 +>candidate_22528041 pos=16:23191959-23191999 +AAAACAACAACAGTACATTCCCTGCCGTGGCCGATGAACT, 2 +>candidate_22528622 pos=16:17193799-17193839 +AAAACAACAACATCAGCACTGGCTGCTCTTCCAGGGGACC, 97 +>candidate_22530271 pos=16:42145836-42145876 +AAAACAACAACCATAAACTACCCTAGACATGGCTTTAAGT, 0 +>candidate_22530532 pos=16:8117580-8117620 +AAAACAACAACCCACTTTGGGTCTATCTCTGTCAATGCTC, 0 +>candidate_22530904 pos=16:58147083-58147123 +AAAACAACAACCGTAAGAAGGAGGCTGGAGGCTGATGCTC, 0 +>candidate_22532719 pos=16:70126324-70126364 +AAAACAACAACTGGCAACAAACAAACGCTTGAGAGGATGT, 0 +>candidate_22534710 pos=16:91136208-91136248 +AAAACAACAAGACTATAGGGGACATCTCATTCAAACACTA, 2 +>candidate_22535706 pos=16:85174980-85175020 +AAAACAACAAGCAGTTTCTGCCACTGCCCAGTTCCTGCTT, 0 +>candidate_22536165 pos=16:55102898-55102938 +AAAACAACAAGCTGTTCACATTTCTCTCCTGGGCGCTACT, 0 +>candidate_22540553 pos=16:12181858-12181898 +AAAACAACAATAGTATGCTCTAACCAACCCATGACTTCCC, 0 +>candidate_22540990 pos=16:41118273-41118313 +AAAACAACAATATCAACTAACTGGACACCTCAGGGATTAA, 299 +>candidate_22542201 pos=16:38187412-38187452 +AAAACAACAATCTAGCCAGCTGGCCTGAGAAAAGTGGGTG, 0 +>candidate_22543874 pos=16:63183017-63183057 +AAAACAACAATGTTGAAAGAAGCCAATATTTGCAGGGGTG, 0 +>candidate_22544870 pos=16:53130099-53130139 +AAAACAACAATTTCAACTAACCAGACTCCCTGTCCCAGAG, 135 +>candidate_22547933 pos=16:27108597-27108637 +AAAACAACACAAGTGGGGAGGGAGGGAGGGATTTGGGAGG, 692 +>candidate_22548148 pos=16:60142430-60142470 +AAAACAACACAATCAGGTCTGTCACAGCAACACTCCATAA, 60 +>candidate_22548235 pos=16:12159703-12159743 +AAAACAACACAATGAGACAGAGAAGCCTGGATTTTAACAA, 1 +>candidate_22548621 pos=16:12161010-12161050 +AAAACAACACACAACTCCACAATACAAGAACTACACTAGA, 0 +>candidate_22550604 pos=16:61104641-61104681 +AAAACAACACAGAGATACACACACATGCATGTACCCACAC, 403 +>candidate_22551772 pos=16:62190688-62190728 +AAAACAACACAGTCAGGTCTGTGACAGCAATACCCCATTA, 199 +>candidate_22553460 pos=16:30124149-30124189 +AAAACAACACATTTCAGGCTGTGTCTTGCCCAGAGTGACT, 3 +>candidate_22554080 pos=16:22145308-22145348 +AAAACAACACCAAGGTCATGGAAGGCAGCTGGTGACATCA, 0 +>candidate_22556001 pos=16:97101262-97101302 +AAAACAACACCGTGACACTCTTGCCTCACATTCTACAAAC, 0 +>candidate_22556004 pos=16:91190766-91190806 +AAAACAACACCGTGGCCCAGCTAATTAGAACACACACTTC, 0 +>candidate_22556430 pos=16:4139209-4139249 +AAAACAACACCTGCTCTAGACTGCAGCAACACAAACTGAA, 0 +>candidate_22557039 pos=16:7141448-7141488 +AAAACAACACGCGGCTCCGTGAACACAATTGCATTGAAAA, 0 +>candidate_22559472 pos=16:47180265-47180305 +AAAACAACACTGAGATTCCACCTCACAACAGTCAGAATGG, 1361 +>candidate_22559612 pos=16:77145310-77145350 +AAAACAACACTGAGATTCCATCTTAGACCTGTCAGAATGG, 1346 +>candidate_22560242 pos=16:37102570-37102610 +AAAACAACACTGGGGAAAAGAGTCTCATTATTATACTCTG, 1 +>candidate_22560764 pos=16:57137711-57137751 +AAAACAACACTTAGCAGGTTTCATTGACATAGGCTTTCAT, 1 +>candidate_22562354 pos=16:72178247-72178287 +AAAACAACAGAAAATGAGTGAGTTGTTTGAAGGCAGCATT, 1 +>candidate_22563296 pos=16:87145435-87145475 +AAAACAACAGAAAGCCCACATACACATGGAAGCTGACCAA, 1180 +>candidate_22563325 pos=16:15143614-15143654 +AAAACAACAGAAAGCCCACATACACGAGGAAACTGAACAA, 1517 diff --git a/test_data/test.ss.ct b/test_data/test.ss.ct new file mode 100644 index 00000000..d20c764a --- /dev/null +++ b/test_data/test.ss.ct @@ -0,0 +1,20300 @@ +40 dG = 0.941 candidate_21654043 pos=16:11114621-11114661 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 C 19 21 0 20 0 21 +21 A 20 22 38 21 20 22 +22 C 21 23 37 22 21 23 +23 T 22 24 36 23 22 0 +24 G 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 C 25 27 0 26 0 0 +27 C 26 28 0 27 0 0 +28 T 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 A 35 37 23 36 0 37 +37 G 36 38 22 37 36 38 +38 T 37 39 21 38 37 39 +39 C 38 40 0 39 38 0 +40 C 39 0 0 40 0 0 +40 dG = 0.584 candidate_21658299 pos=16:22131287-22131327 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 A 23 25 0 24 0 25 +25 G 24 26 35 25 24 26 +26 C 25 27 34 26 25 0 +27 C 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 G 33 35 26 34 0 35 +35 C 34 36 25 35 34 36 +36 C 35 37 0 36 35 0 +37 T 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = 1.134 candidate_21666318 pos=16:31196747-31196787 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 14 +14 A 13 15 25 14 13 15 +15 C 14 16 24 15 14 0 +16 A 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 G 23 25 15 24 0 25 +25 T 24 26 14 25 24 26 +26 A 25 27 0 26 25 0 +27 T 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -0.206 candidate_21670946 pos=16:68188874-68188914 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 A 17 19 0 18 0 19 +19 C 18 20 32 19 18 20 +20 C 19 21 31 20 19 0 +21 G 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 G 24 26 0 25 0 0 +26 T 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 G 30 32 20 31 0 32 +32 G 31 33 19 32 31 33 +33 A 32 34 0 33 32 0 +34 C 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = 0.544 candidate_21676743 pos=16:90188443-90188483 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 A 26 28 0 27 0 28 +28 C 27 29 36 28 27 29 +29 T 28 30 35 29 28 0 +30 C 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 A 34 36 29 35 0 36 +36 G 35 37 28 36 35 37 +37 C 36 38 0 37 36 0 +38 T 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -2.985 candidate_21685155 pos=16:14129896-14129936 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 A 15 17 0 16 0 17 +17 C 16 18 36 17 16 18 +18 C 17 19 35 18 17 19 +19 A 18 20 34 19 18 20 +20 T 19 21 33 20 19 21 +21 G 20 22 32 21 20 0 +22 A 21 23 0 22 0 0 +23 G 22 24 0 23 0 0 +24 G 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 C 25 27 0 26 0 0 +27 T 26 28 0 27 0 0 +28 T 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 G 30 32 0 31 0 0 +32 C 31 33 21 32 0 33 +33 A 32 34 20 33 32 34 +34 T 33 35 19 34 33 35 +35 G 34 36 18 35 34 36 +36 G 35 37 17 36 35 37 +37 G 36 38 0 37 36 0 +38 T 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = 0.941 candidate_21686495 pos=16:11114626-11114666 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 C 14 16 0 15 0 16 +16 A 15 17 33 16 15 17 +17 C 16 18 32 17 16 18 +18 T 17 19 31 18 17 0 +19 G 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 T 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 T 25 27 0 26 0 0 +27 C 26 28 0 27 0 0 +28 T 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 A 30 32 18 31 0 32 +32 G 31 33 17 32 31 33 +33 T 32 34 16 33 32 34 +34 C 33 35 0 34 33 0 +35 C 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -1.847 candidate_21686514 pos=16:81179833-81179873 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 A 13 15 0 14 0 15 +15 C 14 16 33 15 14 16 +16 A 15 17 32 16 15 17 +17 C 16 18 31 17 16 18 +18 T 17 19 30 18 17 0 +19 G 18 20 0 19 0 0 +20 G 19 21 27 20 0 21 +21 A 20 22 26 21 20 0 +22 A 21 23 0 22 0 0 +23 G 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 T 25 27 21 26 0 27 +27 C 26 28 20 27 26 0 +28 T 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 A 29 31 18 30 0 31 +31 G 30 32 17 31 30 32 +32 T 31 33 16 32 31 33 +33 G 32 34 15 33 32 34 +34 A 33 35 0 34 33 0 +35 C 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -1.009 candidate_21686674 pos=16:9163163-9163203 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 10 +10 C 9 11 20 10 9 11 +11 A 10 12 19 11 10 12 +12 A 11 13 18 12 11 0 +13 A 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 T 17 19 12 18 0 19 +19 T 18 20 11 19 18 20 +20 G 19 21 10 20 19 21 +21 A 20 22 0 21 20 0 +22 G 21 23 0 22 0 0 +23 G 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 G 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 C 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -1.469 candidate_21687718 pos=16:70191486-70191526 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 20 +20 C 19 21 30 20 19 21 +21 C 20 22 29 21 20 22 +22 G 21 23 28 22 21 0 +23 C 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 T 27 29 22 28 0 29 +29 G 28 30 21 29 28 30 +30 G 29 31 20 30 29 31 +31 A 30 32 0 31 30 0 +32 G 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = 0.284 candidate_21696099 pos=16:22131292-22131332 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 C 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 G 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 C 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 A 27 29 0 28 0 29 +29 G 28 30 38 29 28 30 +30 C 29 31 37 30 29 0 +31 C 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 C 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 G 36 38 30 37 0 38 +38 C 37 39 29 38 37 39 +39 C 38 40 0 39 38 0 +40 C 39 0 0 40 0 0 +40 dG = 0.388 candidate_21696605 pos=16:76195412-76195452 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 8 +8 A 7 9 31 8 7 9 +9 A 8 10 30 9 8 10 +10 C 9 11 29 10 9 11 +11 A 10 12 28 11 10 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 C 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 G 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 T 25 27 0 26 0 0 +27 C 26 28 0 27 0 0 +28 T 27 29 11 28 0 29 +29 G 28 30 10 29 28 30 +30 T 29 31 9 30 29 31 +31 T 30 32 8 31 30 32 +32 C 31 33 0 32 31 0 +33 T 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -2.403 candidate_21696680 pos=16:23161159-23161199 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 14 +14 A 13 15 38 14 13 15 +15 C 14 16 37 15 14 16 +16 C 15 17 36 16 15 0 +17 C 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 G 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 T 20 22 35 21 0 22 +22 C 21 23 34 22 21 23 +23 T 22 24 33 23 22 24 +24 T 23 25 32 24 23 25 +25 G 24 26 31 25 24 0 +26 A 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 C 30 32 25 31 0 32 +32 A 31 33 24 32 31 33 +33 A 32 34 23 33 32 34 +34 G 33 35 22 34 33 35 +35 A 34 36 21 35 34 0 +36 G 35 37 16 36 0 37 +37 G 36 38 15 37 36 38 +38 T 37 39 14 38 37 39 +39 G 38 40 0 39 38 0 +40 A 39 0 0 40 0 0 +40 dG = -3.598 candidate_21696763 pos=16:33141995-33142035 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 11 +11 A 10 12 27 11 10 12 +12 A 11 13 26 12 11 13 +13 A 12 14 25 13 12 14 +14 A 13 15 24 14 13 15 +15 C 14 16 23 15 14 16 +16 C 15 17 22 16 15 0 +17 C 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 G 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 G 21 23 16 22 0 23 +23 G 22 24 15 23 22 24 +24 T 23 25 14 24 23 25 +25 T 24 26 13 25 24 26 +26 T 25 27 12 26 25 27 +27 T 26 28 11 27 26 28 +28 C 27 29 0 28 27 0 +29 C 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 G 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -1.44 candidate_21696985 pos=16:15154698-15154738 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 4 +4 A 3 5 23 4 3 5 +5 C 4 6 22 5 4 6 +6 A 5 7 21 6 5 7 +7 A 6 8 20 7 6 0 +8 A 7 9 0 8 0 0 +9 A 8 10 18 9 0 10 +10 C 9 11 17 10 9 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 C 15 17 0 16 0 0 +17 G 16 18 10 17 0 18 +18 T 17 19 9 18 17 0 +19 G 18 20 0 19 0 0 +20 T 19 21 7 20 0 21 +21 T 20 22 6 21 20 22 +22 G 21 23 5 22 21 23 +23 T 22 24 4 23 22 24 +24 A 23 25 0 24 23 0 +25 G 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 T 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 T 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -0.505 candidate_21698710 pos=16:73144761-73144801 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 G 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 A 19 21 0 20 0 21 +21 A 20 22 40 21 20 22 +22 T 21 23 39 22 21 23 +23 C 22 24 38 23 22 24 +24 C 23 25 37 24 23 0 +25 T 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 T 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 G 36 38 24 37 0 38 +38 G 37 39 23 38 37 39 +39 A 38 40 22 39 38 40 +40 T 39 0 21 40 39 0 +40 dG = -0.226 candidate_21699937 pos=16:90136408-90136448 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 T 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 A 21 23 0 22 0 23 +23 G 22 24 32 23 22 24 +24 C 23 25 31 24 23 0 +25 C 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 C 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 G 30 32 24 31 0 32 +32 C 31 33 23 32 31 33 +33 A 32 34 0 33 32 0 +34 C 33 35 0 34 0 0 +35 C 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -0.789 candidate_21700882 pos=16:43126383-43126423 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 T 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 T 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 A 23 25 0 24 0 25 +25 C 24 26 34 25 24 26 +26 C 25 27 33 26 25 27 +27 T 26 28 32 27 26 0 +28 T 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 A 31 33 27 32 0 33 +33 G 32 34 26 33 32 34 +34 G 33 35 25 34 33 35 +35 C 34 36 0 35 34 0 +36 G 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -1.554 candidate_21704015 pos=16:47181492-47181532 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 G 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 G 17 19 0 18 0 19 +19 G 18 20 35 19 18 20 +20 C 19 21 34 20 19 0 +21 T 20 22 0 21 0 0 +22 C 21 23 31 22 0 23 +23 T 22 24 30 23 22 24 +24 G 23 25 29 24 23 0 +25 A 24 26 0 25 0 0 +26 G 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 T 27 29 0 28 0 0 +29 C 28 30 24 29 0 30 +30 A 29 31 23 30 29 31 +31 G 30 32 22 31 30 0 +32 T 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 G 33 35 20 34 0 35 +35 C 34 36 19 35 34 36 +36 T 35 37 0 36 35 0 +37 A 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -1.515 candidate_21712832 pos=16:20146964-20147004 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 9 +9 A 8 10 18 9 8 10 +10 C 9 11 17 10 9 11 +11 A 10 12 16 11 10 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 T 14 16 0 15 0 0 +16 T 15 17 11 16 0 17 +17 G 16 18 10 17 16 18 +18 T 17 19 9 18 17 19 +19 A 18 20 0 19 18 0 +20 A 19 21 0 20 0 0 +21 G 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 T 22 24 0 23 0 0 +24 G 23 25 0 24 0 0 +25 G 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 G 26 28 0 27 0 28 +28 G 27 29 35 28 27 29 +29 C 28 30 34 29 28 0 +30 A 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 G 33 35 29 34 0 35 +35 C 34 36 28 35 34 36 +36 T 35 37 0 36 35 0 +37 G 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -0.442 candidate_21717478 pos=16:31196752-31196792 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 G 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 C 24 26 0 25 0 26 +26 C 25 27 39 26 25 27 +27 C 26 28 38 27 26 28 +28 T 27 29 37 28 27 29 +29 A 28 30 36 29 28 0 +30 T 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 C 34 36 0 35 0 0 +36 T 35 37 29 36 0 37 +37 A 36 38 28 37 36 38 +38 G 37 39 27 38 37 39 +39 G 38 40 26 39 38 40 +40 T 39 0 0 40 39 0 +40 dG = -0.206 candidate_21732049 pos=16:68188879-68188919 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 14 +14 C 13 15 27 14 13 15 +15 C 14 16 26 15 14 0 +16 G 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 G 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 G 25 27 15 26 0 27 +27 G 26 28 14 27 26 28 +28 A 27 29 0 28 27 0 +29 C 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -4.761 candidate_21732995 pos=16:48174889-48174929 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 13 +13 A 12 14 32 13 12 14 +14 C 13 15 31 14 13 15 +15 T 14 16 30 15 14 16 +16 C 15 17 29 16 15 17 +17 A 16 18 28 17 16 18 +18 A 17 19 27 18 17 19 +19 G 18 20 26 19 18 0 +20 A 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 G 24 26 0 25 0 0 +26 C 25 27 19 26 0 27 +27 T 26 28 18 27 26 28 +28 T 27 29 17 28 27 29 +29 G 28 30 16 29 28 30 +30 A 29 31 15 30 29 31 +31 G 30 32 14 31 30 32 +32 T 31 33 13 32 31 33 +33 G 32 34 0 33 32 0 +34 A 33 35 0 34 0 0 +35 C 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -3.188 candidate_21734070 pos=16:6153316-6153356 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 10 +10 C 9 11 28 10 9 11 +11 A 10 12 27 11 10 12 +12 A 11 13 26 12 11 13 +13 A 12 14 25 13 12 14 +14 G 13 15 24 14 13 15 +15 A 14 16 23 15 14 0 +16 A 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 T 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 T 22 24 15 23 0 24 +24 C 23 25 14 24 23 25 +25 T 24 26 13 25 24 26 +26 T 25 27 12 26 25 27 +27 T 26 28 11 27 26 28 +28 G 27 29 10 28 27 29 +29 G 28 30 0 29 28 0 +30 G 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = 0.274 candidate_21734516 pos=16:85140354-85140394 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 G 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 20 +20 G 19 21 33 20 19 21 +21 G 20 22 32 21 20 0 +22 A 21 23 0 22 0 0 +23 T 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 G 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 C 31 33 21 32 0 33 +33 C 32 34 20 33 32 34 +34 A 33 35 0 34 33 0 +35 G 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -0.522 candidate_21735207 pos=16:5178254-5178294 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 G 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 G 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 G 19 21 0 20 0 0 +21 G 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 A 22 24 0 23 0 24 +24 C 23 25 37 24 23 25 +25 T 24 26 36 25 24 26 +26 C 25 27 35 26 25 27 +27 G 26 28 34 27 26 0 +28 G 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 G 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 T 33 35 27 34 0 35 +35 G 34 36 26 35 34 36 +36 A 35 37 25 36 35 37 +37 G 36 38 24 37 36 38 +38 G 37 39 0 38 37 0 +39 C 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -0.981 candidate_21738820 pos=16:11141085-11141125 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 G 13 15 0 14 0 15 +15 G 14 16 33 15 14 16 +16 C 15 17 32 16 15 17 +17 T 16 18 31 17 16 19 +18 A 17 19 0 18 0 0 +19 G 18 20 30 19 17 20 +20 A 19 21 29 20 19 21 +21 G 20 22 28 21 20 0 +22 A 21 23 0 22 0 0 +23 G 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 G 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 C 27 29 21 28 0 29 +29 T 28 30 20 29 28 30 +30 C 29 31 19 30 29 31 +31 A 30 32 17 31 30 32 +32 G 31 33 16 32 31 33 +33 C 32 34 15 33 32 34 +34 A 33 35 0 34 33 0 +35 G 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -3.192 candidate_21748103 pos=16:45181671-45181711 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 C 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 C 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 A 23 25 0 24 0 25 +25 C 24 26 37 25 24 26 +26 A 25 27 36 26 25 27 +27 C 26 28 35 27 26 28 +28 A 27 29 34 28 27 0 +29 A 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 G 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 T 33 35 28 34 0 35 +35 G 34 36 27 35 34 36 +36 T 35 37 26 36 35 37 +37 G 36 38 25 37 36 38 +38 A 37 39 0 38 37 0 +39 T 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = 0.544 candidate_21749831 pos=16:90188448-90188488 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 C 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 C 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 A 21 23 0 22 0 23 +23 C 22 24 31 23 22 24 +24 T 23 25 30 24 23 0 +25 C 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 T 28 30 0 29 0 0 +30 A 29 31 24 30 0 31 +31 G 30 32 23 31 30 32 +32 C 31 33 0 32 31 0 +33 T 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 C 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -0.454 candidate_21753987 pos=16:27162495-27162535 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 C 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 G 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 A 17 19 0 18 0 19 +19 G 18 20 38 19 18 20 +20 C 19 21 37 20 19 21 +21 T 20 22 36 21 20 0 +22 C 21 23 33 22 0 23 +23 A 22 24 32 23 22 24 +24 C 23 25 31 24 23 0 +25 A 24 26 0 25 0 0 +26 T 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 G 30 32 24 31 0 32 +32 T 31 33 23 32 31 33 +33 G 32 34 22 33 32 0 +34 G 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 A 35 37 21 36 0 37 +37 G 36 38 20 37 36 38 +38 C 37 39 19 38 37 39 +39 C 38 40 0 39 38 0 +40 G 39 0 0 40 0 0 +40 dG = -0.619 candidate_21755149 pos=16:30168215-30168255 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 12 +12 A 11 13 26 12 11 13 +13 C 12 14 25 13 12 14 +14 C 13 15 24 14 13 0 +15 A 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 G 23 25 14 24 0 25 +25 G 24 26 13 25 24 26 +26 T 25 27 12 26 25 27 +27 G 26 28 0 27 26 0 +28 T 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = 0.124 candidate_21756048 pos=16:16119405-16119445 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 C 12 14 0 13 0 0 +14 C 13 15 0 14 0 15 +15 C 14 16 22 15 14 16 +16 A 15 17 21 16 15 0 +17 A 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 T 20 22 16 21 0 22 +22 G 21 23 15 22 21 23 +23 A 22 24 0 23 22 0 +24 A 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 T 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = 0.164 candidate_21758248 pos=16:33187988-33188028 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 10 +10 C 9 11 18 10 9 11 +11 A 10 12 17 11 10 0 +12 A 11 13 0 12 0 0 +13 C 12 14 0 13 0 0 +14 T 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 G 15 17 0 16 0 0 +17 T 16 18 11 17 0 18 +18 G 17 19 10 18 17 19 +19 G 18 20 0 19 18 0 +20 T 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 T 25 27 0 26 0 0 +27 T 26 28 0 27 0 0 +28 T 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -0.629 candidate_21759100 pos=16:36139573-36139613 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 G 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 T 22 24 0 23 0 24 +24 G 23 25 35 24 23 25 +25 C 24 26 34 25 24 26 +26 T 25 27 33 26 25 0 +27 T 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 A 32 34 26 33 0 34 +34 G 33 35 25 34 33 35 +35 C 34 36 24 35 34 36 +36 T 35 37 0 36 35 0 +37 A 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -1.018 candidate_21759804 pos=16:50168025-50168065 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 11 +11 A 10 12 21 11 10 12 +12 A 11 13 20 12 11 13 +13 G 12 14 19 13 12 0 +14 A 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 C 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 C 18 20 13 19 0 20 +20 T 19 21 12 20 19 21 +21 T 20 22 11 21 20 22 +22 C 21 23 0 22 21 0 +23 C 22 24 0 23 0 0 +24 T 23 25 0 24 0 25 +25 G 24 26 36 25 24 26 +26 C 25 27 35 26 25 27 +27 A 26 28 34 27 26 0 +28 C 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 T 33 35 27 34 0 35 +35 G 34 36 26 35 34 36 +36 C 35 37 25 36 35 37 +37 T 36 38 0 37 36 0 +38 C 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +0 dG = 998.226 candidate_21761043 pos=16:9183788-9183828 +40 dG = 0.751 candidate_21774421 pos=16:82180535-82180575 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 C 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 G 13 15 0 14 0 15 +15 A 14 16 31 15 14 16 +16 C 15 17 30 16 15 17 +17 T 16 18 29 17 16 0 +18 C 17 19 0 18 0 0 +19 T 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 T 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 C 25 27 0 26 0 0 +27 C 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 A 28 30 17 29 0 30 +30 G 29 31 16 30 29 31 +31 T 30 32 15 31 30 32 +32 A 31 33 0 32 31 0 +33 G 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 C 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -2.881 candidate_21775575 pos=16:4115534-4115574 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 C 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 T 13 15 0 14 0 0 +15 T 14 16 0 15 0 0 +16 C 15 17 0 16 0 17 +17 C 16 18 25 17 16 18 +18 C 17 19 24 18 17 19 +19 A 18 20 23 19 18 0 +20 G 19 21 0 20 0 0 +21 G 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 T 22 24 19 23 0 24 +24 G 23 25 18 24 23 25 +25 G 24 26 17 25 24 26 +26 A 25 27 0 26 25 0 +27 T 26 28 0 27 0 0 +28 T 27 29 0 28 0 0 +29 T 28 30 0 29 0 30 +30 G 29 31 40 30 29 31 +31 G 30 32 39 31 30 32 +32 C 31 33 38 32 31 0 +33 T 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 G 37 39 32 38 0 39 +39 C 38 40 31 39 38 40 +40 C 39 0 30 40 39 0 +40 dG = -2.985 candidate_21777113 pos=16:14129901-14129941 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 12 +12 C 11 13 31 12 11 13 +13 C 12 14 30 13 12 14 +14 A 13 15 29 14 13 15 +15 T 14 16 28 15 14 16 +16 G 15 17 27 16 15 0 +17 A 16 18 0 17 0 0 +18 G 17 19 0 18 0 0 +19 G 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 T 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 G 24 26 0 25 0 0 +26 G 25 27 0 26 0 0 +27 C 26 28 16 27 0 28 +28 A 27 29 15 28 27 29 +29 T 28 30 14 29 28 30 +30 G 29 31 13 30 29 31 +31 G 30 32 12 31 30 32 +32 G 31 33 0 32 31 0 +33 T 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 C 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -3.63 candidate_21778714 pos=16:50167929-50167969 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 12 +12 C 11 13 21 12 11 13 +13 C 12 14 20 13 12 14 +14 T 13 15 19 14 13 0 +15 C 14 16 0 15 0 0 +16 C 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 A 18 20 14 19 0 20 +20 G 19 21 13 20 19 21 +21 G 20 22 12 21 20 0 +22 G 21 23 35 22 0 23 +23 C 22 24 34 23 22 24 +24 T 23 25 33 24 23 25 +25 A 24 26 32 25 24 26 +26 G 25 27 31 26 25 0 +27 T 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 C 30 32 26 31 0 32 +32 T 31 33 25 32 31 33 +33 A 32 34 24 33 32 34 +34 G 33 35 23 34 33 35 +35 C 34 36 22 35 34 36 +36 T 35 37 0 36 35 0 +37 A 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -3.876 candidate_21778745 pos=16:85151414-85151454 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 10 +10 C 9 11 39 10 9 11 +11 A 10 12 38 11 10 12 +12 C 11 13 37 12 11 13 +13 C 12 14 36 13 12 14 +14 T 13 15 0 14 13 0 +15 C 14 16 0 15 0 0 +16 T 15 17 0 16 0 17 +17 C 16 18 34 17 16 18 +18 C 17 19 33 18 17 19 +19 T 18 20 32 19 18 20 +20 A 19 21 31 20 19 21 +21 G 20 22 30 21 20 0 +22 A 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 G 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 C 29 31 21 30 0 31 +31 T 30 32 20 31 30 32 +32 A 31 33 19 32 31 33 +33 G 32 34 18 33 32 34 +34 G 33 35 17 34 33 35 +35 T 34 36 0 35 34 36 +36 G 35 37 13 36 35 37 +37 G 36 38 12 37 36 38 +38 T 37 39 11 38 37 39 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0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 C 11 13 0 12 0 0 +13 T 12 14 0 13 0 0 +14 G 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 C 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 T 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 A 25 27 0 26 0 27 +27 G 26 28 36 27 26 28 +28 T 27 29 35 28 27 0 +29 C 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 A 34 36 28 35 0 36 +36 C 35 37 27 36 35 37 +37 A 36 38 0 37 36 0 +38 A 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -1.847 candidate_21780699 pos=16:81179838-81179878 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 10 +10 C 9 11 28 10 9 11 +11 A 10 12 27 11 10 12 +12 C 11 13 26 12 11 13 +13 T 12 14 25 13 12 0 +14 G 13 15 0 14 0 0 +15 G 14 16 22 15 0 16 +16 A 15 17 21 16 15 0 +17 A 16 18 0 17 0 0 +18 G 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 T 20 22 16 21 0 22 +22 C 21 23 15 22 21 0 +23 T 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 A 24 26 13 25 0 26 +26 G 25 27 12 26 25 27 +27 T 26 28 11 27 26 28 +28 G 27 29 10 28 27 29 +29 A 28 30 0 29 28 0 +30 C 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -1.009 candidate_21781230 pos=16:9163168-9163208 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 5 +5 C 4 6 15 5 4 6 +6 A 5 7 14 6 5 7 +7 A 6 8 13 7 6 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 C 11 13 0 12 0 0 +13 T 12 14 7 13 0 14 +14 T 13 15 6 14 13 15 +15 G 14 16 5 15 14 16 +16 A 15 17 0 16 15 0 +17 G 16 18 0 17 0 0 +18 G 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 G 20 22 0 21 0 0 +22 G 21 23 0 22 0 0 +23 G 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 G 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 T 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -1.469 candidate_21784795 pos=16:70191491-70191531 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 G 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 A 13 15 0 14 0 15 +15 C 14 16 25 15 14 16 +16 C 15 17 24 16 15 17 +17 G 16 18 23 17 16 0 +18 C 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 G 21 23 0 22 0 0 +23 T 22 24 17 23 0 24 +24 G 23 25 16 24 23 25 +25 G 24 26 15 25 24 26 +26 A 25 27 0 26 25 0 +27 G 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -3.911 candidate_21785278 pos=16:96178155-96178195 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 G 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 G 14 16 0 15 0 0 +16 G 15 17 0 16 0 17 +17 C 16 18 24 17 16 18 +18 C 17 19 23 18 17 0 +19 A 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 G 22 24 18 23 0 24 +24 G 23 25 17 24 23 25 +25 A 24 26 0 25 24 0 +26 A 25 27 0 26 0 0 +27 A 26 28 0 27 0 28 +28 A 27 29 40 28 27 29 +29 G 28 30 39 29 28 30 +30 G 29 31 38 30 29 31 +31 C 30 32 37 31 30 0 +32 T 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 C 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 G 36 38 31 37 0 38 +38 C 37 39 30 38 37 39 +39 C 38 40 29 39 38 40 +40 T 39 0 28 40 39 0 +40 dG = 0.241 candidate_21785540 pos=16:88192867-88192907 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 8 +8 A 7 9 22 8 7 9 +9 A 8 10 21 9 8 10 +10 C 9 11 20 10 9 0 +11 A 10 12 0 11 0 0 +12 G 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 T 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 G 19 21 10 20 0 21 +21 T 20 22 9 21 20 22 +22 T 21 23 8 22 21 23 +23 A 22 24 0 23 22 0 +24 G 23 25 0 24 0 0 +25 G 24 26 0 25 0 0 +26 C 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 T 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 G 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 G 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -1.875 candidate_21790463 pos=16:73187251-73187291 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 G 11 13 0 12 0 0 +13 G 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 G 15 17 0 16 0 0 +17 G 16 18 0 17 0 18 +18 G 17 19 35 18 17 19 +19 A 18 20 34 19 18 20 +20 A 19 21 33 20 19 21 +21 T 20 22 32 21 20 22 +22 G 21 23 31 22 21 0 +23 A 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 G 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 C 30 32 22 31 0 32 +32 A 31 33 21 32 31 33 +33 T 32 34 20 33 32 34 +34 T 33 35 19 34 33 35 +35 C 34 36 18 35 34 36 +36 A 35 37 0 36 35 0 +37 A 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -2.193 candidate_21791592 pos=16:61181111-61181151 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 10 +10 C 9 11 34 10 9 11 +11 A 10 12 33 11 10 12 +12 G 11 13 32 12 11 13 +13 G 12 14 31 13 12 14 +14 G 13 15 30 14 13 0 +15 A 14 16 25 15 0 16 +16 G 15 17 24 16 15 17 +17 G 16 18 23 17 16 0 +18 A 17 19 0 18 0 0 +19 G 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 G 21 23 0 22 0 0 +23 C 22 24 17 23 0 24 +24 C 23 25 16 24 23 25 +25 T 24 26 15 25 24 0 +26 T 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 T 29 31 14 30 0 31 +31 C 30 32 13 31 30 32 +32 C 31 33 12 32 31 33 +33 T 32 34 11 33 32 34 +34 G 33 35 10 34 33 35 +35 G 34 36 0 35 34 0 +36 A 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -0.582 candidate_21792153 pos=16:20134652-20134692 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 9 +9 A 8 10 36 9 8 10 +10 C 9 11 35 10 9 11 +11 A 10 12 34 11 10 12 +12 G 11 13 33 12 11 0 +13 G 12 14 0 13 0 0 +14 T 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 C 15 17 0 16 0 0 +17 T 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 G 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 G 21 23 0 22 0 0 +23 G 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 C 32 34 12 33 0 34 +34 T 33 35 11 34 33 35 +35 G 34 36 10 35 34 36 +36 T 35 37 9 36 35 37 +37 A 36 38 0 37 36 0 +38 G 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = 0.834 candidate_21792914 pos=16:22154266-22154306 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 4 +4 A 3 5 13 4 3 5 +5 C 4 6 12 5 4 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 G 11 13 5 12 0 13 +13 T 12 14 4 13 12 14 +14 A 13 15 0 14 13 0 +15 T 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 G 17 19 0 18 0 0 +19 T 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 G 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 G 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 C 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 C 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -5.818 candidate_21793507 pos=16:11160012-11160052 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 10 +10 C 9 11 25 10 9 11 +11 A 10 12 24 11 10 12 +12 G 11 13 23 12 11 13 +13 T 12 14 22 13 12 14 +14 G 13 15 21 14 13 15 +15 C 14 16 20 15 14 0 +16 C 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 G 17 19 0 18 0 0 +19 T 18 20 0 19 0 0 +20 G 19 21 15 20 0 21 +21 C 20 22 14 21 20 22 +22 A 21 23 13 22 21 23 +23 C 22 24 12 23 22 24 +24 T 23 25 11 24 23 25 +25 G 24 26 10 25 24 26 +26 G 25 27 0 26 25 0 +27 T 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = 0.011 candidate_21795805 pos=16:14150563-14150603 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 T 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 T 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 T 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 G 21 23 0 22 0 0 +23 T 22 24 0 23 0 24 +24 G 23 25 36 24 23 25 +25 A 24 26 35 25 24 26 +26 G 25 27 34 26 25 0 +27 T 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 C 33 35 26 34 0 35 +35 T 34 36 25 35 34 36 +36 C 35 37 24 36 35 37 +37 T 36 38 0 37 36 0 +38 G 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -1.002 candidate_21797204 pos=16:6123369-6123409 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 10 +10 C 9 11 30 10 9 11 +11 A 10 12 29 11 10 12 +12 T 11 13 28 12 11 13 +13 C 12 14 27 13 12 0 +14 A 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 G 22 24 0 23 0 0 +24 G 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 G 26 28 13 27 0 28 +28 A 27 29 12 28 27 29 +29 T 28 30 11 29 28 30 +30 G 29 31 10 30 29 31 +31 G 30 32 0 31 30 0 +32 C 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 C 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -0.715 candidate_21798346 pos=16:83195310-83195350 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 10 +10 C 9 11 20 10 9 11 +11 A 10 12 19 11 10 12 +12 T 11 13 18 12 11 0 +13 G 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 T 16 18 0 17 0 0 +18 A 17 19 12 18 0 19 +19 T 18 20 11 19 18 20 +20 G 19 21 10 20 19 21 +21 G 20 22 0 21 20 0 +22 T 21 23 0 22 0 0 +23 G 22 24 0 23 0 0 +24 A 23 25 0 24 0 25 +25 C 24 26 38 25 24 26 +26 C 25 27 37 26 25 0 +27 A 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 G 35 37 0 36 0 0 +37 G 36 38 26 37 0 38 +38 G 37 39 25 38 37 39 +39 A 38 40 0 39 38 0 +40 G 39 0 0 40 0 0 +40 dG = -0.509 candidate_21806808 pos=16:36186937-36186977 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 A 22 24 0 23 0 24 +24 C 23 25 36 24 23 25 +25 A 24 26 35 25 24 26 +26 G 25 27 34 26 25 0 +27 A 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 C 33 35 26 34 0 35 +35 T 34 36 25 35 34 36 +36 G 35 37 24 36 35 37 +37 G 36 38 0 37 36 0 +38 G 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -1.157 candidate_21808115 pos=16:44115256-44115296 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 5 +5 C 4 6 38 5 4 6 +6 A 5 7 37 6 5 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 35 9 0 10 +10 C 9 11 34 10 9 11 +11 C 10 12 33 11 10 12 +12 A 11 13 32 12 11 0 +13 A 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 C 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 G 25 27 0 26 0 0 +27 C 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 T 31 33 12 32 0 33 +33 G 32 34 11 33 32 34 +34 G 33 35 10 34 33 35 +35 T 34 36 9 35 34 0 +36 A 35 37 0 36 0 0 +37 T 36 38 6 37 0 38 +38 G 37 39 5 38 37 39 +39 A 38 40 0 39 38 0 +40 A 39 0 0 40 0 0 +40 dG = -1.632 candidate_21808347 pos=16:39121119-39121159 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 T 15 17 0 16 0 0 +17 T 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 G 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 T 22 24 0 23 0 0 +24 G 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 T 25 27 0 26 0 27 +27 C 26 28 38 27 26 28 +28 A 27 29 37 28 27 29 +29 A 28 30 36 29 28 30 +30 G 29 31 35 30 29 0 +31 T 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 C 34 36 30 35 0 36 +36 T 35 37 29 36 35 37 +37 T 36 38 28 37 36 38 +38 G 37 39 27 38 37 39 +39 T 38 40 0 39 38 0 +40 G 39 0 0 40 0 0 +40 dG = -4.895 candidate_21814235 pos=16:91158849-91158889 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 10 +10 C 9 11 39 10 9 11 +11 C 10 12 38 11 10 12 +12 A 11 13 37 12 11 13 +13 C 12 14 36 13 12 0 +14 T 13 15 0 14 0 0 +15 G 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 C 20 22 35 21 0 22 +22 C 21 23 34 22 21 23 +23 A 22 24 33 23 22 24 +24 A 23 25 32 24 23 25 +25 G 24 26 31 25 24 0 +26 A 25 27 0 26 0 0 +27 T 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 C 30 32 25 31 0 32 +32 T 31 33 24 32 31 33 +33 T 32 34 23 33 32 34 +34 G 33 35 22 34 33 35 +35 G 34 36 21 35 34 0 +36 G 35 37 13 36 0 37 +37 T 36 38 12 37 36 38 +38 G 37 39 11 38 37 39 +39 G 38 40 10 39 38 40 +40 A 39 0 0 40 39 0 +40 dG = -2.204 candidate_21814624 pos=16:18106422-18106462 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 G 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 20 +20 G 19 21 38 20 19 21 +21 C 20 22 37 21 20 22 +22 C 21 23 36 22 21 0 +23 A 22 24 33 23 0 24 +24 C 23 25 32 24 23 25 +25 A 24 26 31 25 24 0 +26 T 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 T 30 32 25 31 0 32 +32 G 31 33 24 32 31 33 +33 T 32 34 23 33 32 0 +34 T 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 G 35 37 22 36 0 37 +37 G 36 38 21 37 36 38 +38 C 37 39 20 38 37 39 +39 A 38 40 0 39 38 0 +40 T 39 0 0 40 0 0 +40 dG = -0.789 candidate_21815172 pos=16:53106595-53106635 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 G 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 G 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 T 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 G 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 T 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 T 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 T 32 34 0 33 0 34 +34 G 33 35 40 34 33 35 +35 G 34 36 39 35 34 0 +36 G 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 C 38 40 35 39 0 40 +40 C 39 0 34 40 39 0 +40 dG = -0.384 candidate_21815808 pos=16:22192173-22192213 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 A 11 13 0 12 0 13 +13 G 12 14 30 13 12 14 +14 G 13 15 29 14 13 15 +15 A 14 16 28 15 14 0 +16 C 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 G 17 19 26 18 0 19 +19 T 18 20 25 19 18 0 +20 G 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 G 21 23 0 22 0 0 +23 T 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 A 24 26 19 25 0 26 +26 C 25 27 18 26 25 0 +27 C 26 28 0 27 0 0 +28 T 27 29 15 28 0 29 +29 C 28 30 14 29 28 30 +30 C 29 31 13 30 29 31 +31 A 30 32 0 31 30 0 +32 A 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -1.722 candidate_21817435 pos=16:6147636-6147676 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 10 +10 C 9 11 24 10 9 11 +11 C 10 12 23 11 10 12 +12 A 11 13 22 12 11 13 +13 T 12 14 21 13 12 0 +14 G 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 G 18 20 0 19 0 0 +20 G 19 21 0 20 0 0 +21 A 20 22 13 21 0 22 +22 T 21 23 12 22 21 23 +23 G 22 24 11 23 22 24 +24 G 23 25 10 24 23 25 +25 A 24 26 0 25 24 0 +26 T 25 27 0 26 0 0 +27 T 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 T 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 G 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = 0.284 candidate_21822694 pos=16:22131297-22131337 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 C 11 13 0 12 0 0 +13 C 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 G 14 16 0 15 0 0 +16 C 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 A 22 24 0 23 0 24 +24 G 23 25 33 24 23 25 +25 C 24 26 32 25 24 0 +26 C 25 27 0 26 0 0 +27 T 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 G 31 33 25 32 0 33 +33 C 32 34 24 33 32 34 +34 C 33 35 0 34 33 0 +35 C 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -4.574 candidate_21822783 pos=16:41170402-41170442 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 8 +8 A 7 9 40 8 7 9 +9 A 8 10 39 9 8 10 +10 C 9 11 38 10 9 11 +11 C 10 12 37 11 10 12 +12 C 11 13 36 12 11 13 +13 C 12 14 35 13 12 14 +14 A 13 15 34 14 13 0 +15 T 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 G 17 19 0 18 0 0 +19 T 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 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A 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -1.232 candidate_21823586 pos=16:6111442-6111482 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 C 11 13 0 12 0 0 +13 C 12 14 0 13 0 0 +14 T 13 15 0 14 0 0 +15 T 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 T 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 G 20 22 0 21 0 0 +22 G 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 G 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 G 25 27 0 26 0 0 +27 C 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 C 28 30 0 29 0 30 +30 C 29 31 40 30 29 31 +31 C 30 32 39 31 30 32 +32 C 31 33 38 32 31 0 +33 T 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 C 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 G 37 39 32 38 0 39 +39 G 38 40 31 39 38 40 +40 G 39 0 30 40 39 0 +40 dG = 0.044 candidate_21824607 pos=16:76195417-76195457 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 C 11 13 0 12 0 0 +13 T 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 T 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 G 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 T 22 24 0 23 0 0 +24 G 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 T 25 27 0 26 0 0 +27 C 26 28 0 27 0 0 +28 T 27 29 0 28 0 0 +29 T 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 T 30 32 0 31 0 32 +32 C 31 33 39 32 31 33 +33 C 32 34 38 33 32 0 +34 T 33 35 0 34 0 0 +35 C 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 G 37 39 33 38 0 39 +39 G 38 40 32 39 38 40 +40 T 39 0 0 40 39 0 +40 dG = -3.011 candidate_21824874 pos=16:23161164-23161204 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 5 +5 C 4 6 38 5 4 6 +6 A 5 7 37 6 5 7 +7 A 6 8 36 7 6 0 +8 A 7 9 0 8 0 0 +9 A 8 10 33 9 0 10 +10 C 9 11 32 10 9 11 +11 C 10 12 31 11 10 0 +12 C 11 13 0 12 0 0 +13 T 12 14 0 13 0 0 +14 G 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 T 15 17 30 16 0 17 +17 C 16 18 29 17 16 18 +18 T 17 19 28 18 17 19 +19 T 18 20 27 19 18 20 +20 G 19 21 26 20 19 0 +21 A 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 G 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 C 25 27 20 26 0 27 +27 A 26 28 19 27 26 28 +28 A 27 29 18 28 27 29 +29 G 28 30 17 29 28 30 +30 A 29 31 16 30 29 0 +31 G 30 32 11 31 0 32 +32 G 31 33 10 32 31 33 +33 T 32 34 9 33 32 0 +34 G 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 T 35 37 7 36 0 37 +37 T 36 38 6 37 36 38 +38 G 37 39 5 38 37 39 +39 G 38 40 0 39 38 0 +40 A 39 0 0 40 0 0 +40 dG = -5.103 candidate_21825189 pos=16:33142000-33142040 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 6 +6 A 5 7 22 6 5 7 +7 A 6 8 21 7 6 8 +8 A 7 9 20 8 7 9 +9 A 8 10 19 9 8 10 +10 C 9 11 18 10 9 11 +11 C 10 12 17 11 10 0 +12 C 11 13 0 12 0 0 +13 T 12 14 0 13 0 0 +14 G 13 15 0 14 0 0 +15 T 14 16 0 15 0 0 +16 T 15 17 0 16 0 0 +17 G 16 18 11 17 0 18 +18 G 17 19 10 18 17 19 +19 T 18 20 9 19 18 20 +20 T 19 21 8 20 19 21 +21 T 20 22 7 21 20 22 +22 T 21 23 6 22 21 23 +23 C 22 24 0 23 22 0 +24 C 23 25 0 24 0 25 +25 G 24 26 39 25 24 26 +26 A 25 27 38 26 25 27 +27 C 26 28 37 27 26 28 +28 T 27 29 36 28 27 29 +29 T 28 30 35 29 28 0 +30 A 29 31 0 30 0 0 +31 G 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 G 34 36 29 35 0 36 +36 A 35 37 28 36 35 37 +37 G 36 38 27 37 36 38 +38 T 37 39 26 38 37 39 +39 C 38 40 25 39 38 40 +40 A 39 0 0 40 39 0 +40 dG = -0.922 candidate_21826337 pos=16:15154703-15154743 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 3 +3 A 2 4 16 3 2 4 +4 A 3 5 15 4 3 5 +5 C 4 6 14 5 4 6 +6 A 5 7 13 6 5 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 G 11 13 0 12 0 0 +13 T 12 14 6 13 0 14 +14 G 13 15 5 14 13 15 +15 T 14 16 4 15 14 16 +16 T 15 17 3 16 15 17 +17 G 16 18 0 17 16 0 +18 T 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 G 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 G 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 C 25 27 0 26 0 0 +27 C 26 28 0 27 0 0 +28 T 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 G 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -0.626 candidate_21829358 pos=16:38192572-38192612 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 4 +4 A 3 5 36 4 3 5 +5 C 4 6 35 5 4 6 +6 A 5 7 34 6 5 7 +7 A 6 8 33 7 6 8 +8 A 7 9 32 8 7 9 +9 A 8 10 0 9 8 0 +10 C 9 11 0 10 0 11 +11 C 10 12 28 11 10 12 +12 T 11 13 27 12 11 13 +13 G 12 14 26 13 12 0 +14 G 13 15 0 14 0 0 +15 C 14 16 23 15 0 16 +16 T 15 17 22 16 15 0 +17 A 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 T 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 A 21 23 16 22 0 23 +23 G 22 24 15 23 22 0 +24 T 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 C 25 27 13 26 0 27 +27 A 26 28 12 27 26 28 +28 G 27 29 11 28 27 29 +29 T 28 30 0 29 28 0 +30 G 29 31 0 30 0 0 +31 C 30 32 0 31 0 32 +32 T 31 33 8 32 31 33 +33 T 32 34 7 33 32 34 +34 T 33 35 6 34 33 35 +35 G 34 36 5 35 34 36 +36 T 35 37 4 36 35 37 +37 C 36 38 0 37 36 0 +38 C 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -0.67 candidate_21833371 pos=16:69120689-69120729 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 9 +9 A 8 10 39 9 8 10 +10 C 9 11 38 10 9 0 +11 G 10 12 0 11 0 0 +12 A 11 13 36 12 0 13 +13 T 12 14 35 13 12 14 +14 G 13 15 34 14 13 15 +15 T 14 16 33 15 14 0 +16 A 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 G 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 A 32 34 15 33 0 34 +34 C 33 35 14 34 33 35 +35 A 34 36 13 35 34 36 +36 T 35 37 12 36 35 0 +37 G 36 38 0 37 0 0 +38 G 37 39 10 38 0 39 +39 T 38 40 9 39 38 40 +40 A 39 0 0 40 39 0 +40 dG = -1.179 candidate_21834136 pos=16:90170058-90170098 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 10 +10 C 9 11 27 10 9 11 +11 G 10 12 26 11 10 12 +12 G 11 13 25 12 11 0 +13 A 12 14 0 13 0 0 +14 G 13 15 0 14 0 0 +15 G 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 G 23 25 0 24 0 0 +25 C 24 26 12 25 0 26 +26 C 25 27 11 26 25 27 +27 G 26 28 10 27 26 28 +28 C 27 29 0 28 27 0 +29 T 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -1.249 candidate_21834208 pos=16:73144766-73144806 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 G 10 12 0 11 0 0 +12 G 11 13 0 12 0 0 +13 C 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 T 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 T 25 27 0 26 0 27 +27 G 26 28 37 27 26 28 +28 G 27 29 36 28 27 29 +29 A 28 30 35 29 28 0 +30 G 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 T 34 36 29 35 0 36 +36 C 35 37 28 36 35 37 +37 C 36 38 27 37 36 38 +38 T 37 39 0 38 37 0 +39 T 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -0.126 candidate_21834785 pos=16:27141570-27141610 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 G 10 12 0 11 0 0 +12 T 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 T 13 15 0 14 0 0 +15 G 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 C 18 20 0 19 0 20 +20 C 19 21 26 20 19 21 +21 A 20 22 25 21 20 0 +22 G 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 T 24 26 21 25 0 26 +26 G 25 27 20 26 25 27 +27 A 26 28 0 27 26 0 +28 G 27 29 0 28 0 0 +29 T 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 G 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = 1.524 candidate_21838028 pos=16:4109470-4109510 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 T 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 T 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 C 15 17 0 16 0 0 +17 C 16 18 0 17 0 18 +18 C 17 19 33 18 17 19 +19 A 18 20 32 19 18 0 +20 A 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 T 25 27 0 26 0 0 +27 T 26 28 0 27 0 0 +28 T 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 T 31 33 19 32 0 33 +33 G 32 34 18 33 32 34 +34 A 33 35 0 34 33 0 +35 T 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = 0.874 candidate_21838265 pos=16:70179074-70179114 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 T 10 12 0 11 0 0 +12 A 11 13 0 12 0 13 +13 C 12 14 22 13 12 14 +14 A 13 15 21 14 13 0 +15 A 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 T 20 22 14 21 0 22 +22 G 21 23 13 22 21 23 +23 C 22 24 0 23 22 0 +24 C 23 25 0 24 0 0 +25 G 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 G 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -2.577 candidate_21838416 pos=16:31102444-31102484 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 T 10 12 0 11 0 0 +12 A 11 13 0 12 0 13 +13 C 12 14 40 13 12 14 +14 A 13 15 39 14 13 15 +15 C 14 16 38 15 14 0 +16 A 15 17 0 16 0 0 +17 A 16 18 36 17 0 18 +18 C 17 19 35 18 17 19 +19 A 18 20 34 19 18 0 +20 C 19 21 0 20 0 0 +21 G 20 22 32 21 0 22 +22 G 21 23 31 22 21 23 +23 A 22 24 30 23 22 24 +24 A 23 25 29 24 23 0 +25 G 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 T 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 T 28 30 24 29 0 30 +30 T 29 31 23 30 29 31 +31 C 30 32 22 31 30 32 +32 T 31 33 21 32 31 0 +33 C 32 34 0 33 0 0 +34 T 33 35 19 34 0 35 +35 G 34 36 18 35 34 36 +36 T 35 37 17 36 35 0 +37 A 36 38 0 37 0 0 +38 G 37 39 15 38 0 39 +39 T 38 40 14 39 38 40 +40 G 39 0 13 40 39 0 +40 dG = -0.895 candidate_21839431 pos=16:24135799-24135839 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 8 +8 A 7 9 18 8 7 9 +9 A 8 10 17 9 8 10 +10 C 9 11 16 10 9 0 +11 T 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 G 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 G 14 16 0 15 0 0 +16 G 15 17 10 16 0 17 +17 T 16 18 9 17 16 18 +18 T 17 19 8 18 17 19 +19 C 18 20 0 19 18 0 +20 A 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 G 22 24 0 23 0 0 +24 G 23 25 0 24 0 0 +25 G 24 26 0 25 0 0 +26 A 25 27 0 26 0 27 +27 G 26 28 35 27 26 28 +28 G 27 29 34 28 27 0 +29 A 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 C 33 35 28 34 0 35 +35 C 34 36 27 35 34 36 +36 A 35 37 0 36 35 0 +37 A 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -1.055 candidate_21841895 pos=16:90136413-90136453 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 10 +10 C 9 11 26 10 9 11 +11 T 10 12 25 11 10 12 +12 C 11 13 24 12 11 0 +13 A 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 T 14 16 0 15 0 0 +16 T 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 G 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 G 23 25 12 24 0 25 +25 A 24 26 11 25 24 26 +26 G 25 27 10 26 25 27 +27 C 26 28 0 27 26 0 +28 A 27 29 0 28 0 29 +29 C 28 30 36 29 28 30 +30 C 29 31 35 30 29 0 +31 A 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 G 34 36 30 35 0 36 +36 G 35 37 29 36 35 37 +37 A 36 38 0 37 36 0 +38 C 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -1.541 candidate_21842556 pos=16:68125708-68125748 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 8 +8 A 7 9 40 8 7 9 +9 A 8 10 39 9 8 10 +10 C 9 11 38 10 9 11 +11 T 10 12 37 11 10 12 +12 C 11 13 36 12 11 13 +13 A 12 14 35 13 12 0 +14 T 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 G 21 23 0 22 0 0 +23 T 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 G 25 27 0 26 0 0 +27 C 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 T 34 36 13 35 0 36 +36 G 35 37 12 36 35 37 +37 A 36 38 11 37 36 38 +38 G 37 39 10 38 37 39 +39 T 38 40 9 39 38 40 +40 T 39 0 8 40 39 0 +40 dG = 0.761 candidate_21842776 pos=16:14112129-14112169 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 T 10 12 0 11 0 0 +12 C 11 13 0 12 0 0 +13 C 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 A 24 26 0 25 0 26 +26 C 25 27 40 26 25 27 +27 C 26 28 39 27 26 0 +28 A 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 G 30 32 0 31 0 0 +32 C 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pos=16:43126388-43126428 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 T 10 12 0 11 0 0 +12 G 11 13 0 12 0 0 +13 C 12 14 0 13 0 0 +14 T 13 15 0 14 0 0 +15 T 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 A 18 20 0 19 0 20 +20 C 19 21 36 20 19 21 +21 C 20 22 35 21 20 0 +22 T 21 23 0 22 0 0 +23 T 22 24 33 23 0 24 +24 G 23 25 32 24 23 25 +25 C 24 26 31 25 24 0 +26 C 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 G 30 32 25 31 0 32 +32 C 31 33 24 32 31 33 +33 A 32 34 23 33 32 0 +34 T 33 35 0 34 0 0 +35 G 34 36 21 35 0 36 +36 G 35 37 20 36 35 37 +37 A 36 38 0 37 36 0 +38 T 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -1.906 candidate_21848800 pos=16:84137050-84137090 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 5 +5 C 4 6 27 5 4 6 +6 A 5 7 26 6 5 0 +7 A 6 8 0 7 0 0 +8 A 7 9 24 8 0 9 +9 A 8 10 23 9 8 10 +10 C 9 11 22 10 9 11 +11 T 10 12 21 11 10 12 +12 G 11 13 20 12 11 13 +13 T 12 14 19 13 12 0 +14 G 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 T 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 A 18 20 13 19 0 20 +20 T 19 21 12 20 19 21 +21 A 20 22 11 21 20 22 +22 G 21 23 10 22 21 23 +23 T 22 24 9 23 22 24 +24 T 23 25 8 24 23 0 +25 G 24 26 0 25 0 0 +26 T 25 27 6 26 0 27 +27 G 26 28 5 27 26 28 +28 A 27 29 0 28 27 0 +29 A 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 G 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -0.469 candidate_21849939 pos=16:90133192-90133232 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 T 10 12 0 11 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20 0 +22 G 21 23 0 22 0 0 +23 G 22 24 0 23 0 0 +24 G 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 G 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 A 36 38 21 37 0 38 +38 C 37 39 20 38 37 39 +39 C 38 40 19 39 38 40 +40 C 39 0 18 40 39 0 +40 dG = -0.929 candidate_21852860 pos=16:63108540-63108580 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 5 +5 C 4 6 14 5 4 6 +6 A 5 7 13 6 5 7 +7 A 6 8 12 7 6 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 T 10 12 0 11 0 0 +12 T 11 13 7 12 0 13 +13 T 12 14 6 13 12 14 +14 G 13 15 5 14 13 15 +15 G 14 16 0 15 14 0 +16 T 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 G 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 G 20 22 0 21 0 0 +22 G 21 23 0 22 0 0 +23 T 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 T 25 27 0 26 0 0 +27 G 26 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0 33 0 0 +34 T 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 A 37 39 32 38 0 39 +39 G 38 40 31 39 38 40 +40 A 39 0 30 40 39 0 +40 dG = 0.141 candidate_21858474 pos=16:22172199-22172239 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 G 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 T 14 16 0 15 0 0 +16 G 15 17 0 16 0 0 +17 G 16 18 0 17 0 18 +18 A 17 19 37 18 17 19 +19 G 18 20 36 19 18 20 +20 G 19 21 35 20 19 0 +21 A 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 G 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 G 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 C 34 36 20 35 0 36 +36 C 35 37 19 36 35 37 +37 T 36 38 18 37 36 38 +38 T 37 39 0 38 37 0 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2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 G 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 T 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 T 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 G 19 21 0 20 0 0 +21 T 20 22 0 21 0 22 +22 G 21 23 31 22 21 23 +23 G 22 24 30 23 22 0 +24 C 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 C 29 31 23 30 0 31 +31 C 30 32 22 31 30 32 +32 A 31 33 0 32 31 0 +33 G 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -1.526 candidate_21863612 pos=16:17180243-17180283 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 7 +7 A 6 8 28 7 6 8 +8 A 7 9 27 8 7 9 +9 A 8 10 26 9 8 10 +10 G 9 11 25 10 9 11 +11 A 10 12 24 11 10 0 +12 A 11 13 0 12 0 0 +13 G 12 14 0 13 0 0 +14 T 13 15 21 14 0 15 +15 G 14 16 20 15 14 0 +16 A 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 G 17 19 0 18 0 0 +19 G 18 20 0 19 0 0 +20 C 19 21 15 20 0 21 +21 A 20 22 14 21 20 0 +22 G 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 T 23 25 11 24 0 25 +25 C 24 26 10 25 24 26 +26 T 25 27 9 26 25 27 +27 T 26 28 8 27 26 28 +28 T 27 29 7 28 27 29 +29 G 28 30 0 29 28 0 +30 T 29 31 0 30 0 0 +31 G 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 G 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -1.492 candidate_21864202 pos=16:84196585-84196625 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 G 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 T 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 C 14 16 0 15 0 16 +16 A 15 17 29 16 15 17 +17 C 16 18 28 17 16 18 +18 T 17 19 27 18 17 19 +19 G 18 20 26 19 18 0 +20 T 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 T 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 C 25 27 19 26 0 27 +27 A 26 28 18 27 26 28 +28 G 27 29 17 28 27 29 +29 T 28 30 16 29 28 30 +30 A 29 31 0 30 29 0 +31 C 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -1.008 candidate_21864435 pos=16:8132196-8132236 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 9 +9 A 8 10 22 9 8 10 +10 G 9 11 21 10 9 11 +11 A 10 12 20 11 10 12 +12 A 11 13 19 12 11 0 +13 T 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 T 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 T 18 20 12 19 0 20 +20 T 19 21 11 20 19 21 +21 C 20 22 10 21 20 22 +22 T 21 23 9 22 21 23 +23 C 22 24 0 23 22 0 +24 A 23 25 0 24 0 0 +25 G 24 26 0 25 0 0 +26 C 25 27 0 26 0 0 +27 A 26 28 0 27 0 28 +28 C 27 29 35 28 27 29 +29 C 28 30 34 29 28 0 +30 T 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 G 33 35 29 34 0 35 +35 G 34 36 28 35 34 36 +36 A 35 37 0 36 35 0 +37 A 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -2.238 candidate_21866061 pos=16:42197679-42197719 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 G 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 13 +13 T 12 14 36 13 12 14 +14 G 13 15 35 14 13 15 +15 G 14 16 34 15 14 16 +16 A 15 17 33 16 15 17 +17 G 16 18 32 17 16 0 +18 A 17 19 0 18 0 0 +19 G 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 G 22 24 0 23 0 0 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+29 T 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -3.572 candidate_21868748 pos=16:96107225-96107265 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 G 9 11 0 10 0 11 +11 A 10 12 22 11 10 12 +12 C 11 13 21 12 11 13 +13 C 12 14 20 13 12 14 +14 A 13 15 19 14 13 0 +15 G 14 16 0 15 0 0 +16 G 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 T 18 20 14 19 0 20 +20 G 19 21 13 20 19 21 +21 G 20 22 12 21 20 22 +22 T 21 23 11 22 21 23 +23 G 22 24 0 23 22 0 +24 G 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 T 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -0.806 candidate_21868751 pos=16:44165904-44165944 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 G 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 C 11 13 0 12 0 0 +13 C 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 G 14 16 0 15 0 0 +16 G 15 17 0 16 0 0 +17 T 16 18 0 17 0 0 +18 G 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 C 19 21 0 20 0 21 +21 C 20 22 28 21 20 22 +22 A 21 23 27 22 21 0 +23 G 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 T 26 28 22 27 0 28 +28 G 27 29 21 28 27 29 +29 T 28 30 0 29 28 0 +30 G 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -5.143 candidate_21871569 pos=16:24108671-24108711 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 G 9 11 0 10 0 11 +11 A 10 12 23 11 10 12 +12 G 11 13 22 12 11 13 +13 C 12 14 21 13 12 14 +14 A 13 15 20 14 13 0 +15 C 14 16 0 15 0 0 +16 T 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 T 18 20 0 19 0 0 +20 T 19 21 14 20 0 21 +21 G 20 22 13 21 20 22 +22 C 21 23 12 22 21 23 +23 T 22 24 11 23 22 0 +24 C 23 25 37 24 0 25 +25 A 24 26 36 25 24 26 +26 G 25 27 35 26 25 27 +27 G 26 28 34 27 26 28 +28 T 27 29 33 28 27 0 +29 A 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 A 32 34 28 33 0 34 +34 C 33 35 27 34 33 35 +35 C 34 36 26 35 34 36 +36 T 35 37 25 36 35 37 +37 G 36 38 24 37 36 38 +38 T 37 39 0 38 37 0 +39 T 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -0.226 candidate_21872058 pos=16:17195497-17195537 +1 A 0 2 0 1 0 0 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10 0 9 0 0 +10 G 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 G 11 13 0 12 0 0 +13 G 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 T 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 G 18 20 0 19 0 0 +20 G 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 G 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 G 24 26 0 25 0 0 +26 T 25 27 0 26 0 27 +27 G 26 28 35 27 26 28 +28 T 27 29 34 28 27 0 +29 A 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 G 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 A 33 35 28 34 0 35 +35 C 34 36 27 35 34 36 +36 A 35 37 0 36 35 0 +37 G 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -1.554 candidate_21872467 pos=16:47181497-47181537 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 G 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 G 11 13 0 12 0 0 +13 G 12 14 0 13 0 14 +14 G 13 15 30 14 13 15 +15 C 14 16 29 15 14 0 +16 T 15 17 0 16 0 0 +17 C 16 18 26 17 0 18 +18 T 17 19 25 18 17 19 +19 G 18 20 24 19 18 0 +20 A 19 21 0 20 0 0 +21 G 20 22 0 21 0 0 +22 G 21 23 0 22 0 0 +23 T 22 24 0 23 0 0 +24 C 23 25 19 24 0 25 +25 A 24 26 18 25 24 26 +26 G 25 27 17 26 25 0 +27 T 26 28 0 27 0 0 +28 T 27 29 0 28 0 0 +29 G 28 30 15 29 0 30 +30 C 29 31 14 30 29 31 +31 T 30 32 0 31 30 0 +32 A 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -3.062 candidate_21872626 pos=16:43122088-43122128 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 G 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 G 11 13 0 12 0 0 +13 G 12 14 0 13 0 0 +14 T 13 15 0 14 0 0 +15 G 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 G 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 G 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 T 25 27 0 26 0 27 +27 G 26 28 39 27 26 28 +28 C 27 29 38 28 27 29 +29 A 28 30 37 29 28 30 +30 G 29 31 36 30 29 0 +31 T 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 C 35 37 30 36 0 37 +37 T 36 38 29 37 36 38 +38 G 37 39 28 38 37 39 +39 C 38 40 27 39 38 40 +40 C 39 0 0 40 39 0 +40 dG = 0.494 candidate_21874668 pos=16:6176861-6176901 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 9 +9 A 8 10 17 9 8 10 +10 G 9 11 16 10 9 0 +11 A 10 12 0 11 0 0 +12 T 11 13 0 12 0 0 +13 C 12 14 0 13 0 0 +14 T 13 15 0 14 0 0 +15 G 14 16 0 15 0 0 +16 C 15 17 10 16 0 17 +17 T 16 18 9 17 16 18 +18 A 17 19 0 18 17 0 +19 A 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 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31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -0.847 candidate_21875178 pos=16:44178494-44178534 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 G 9 11 0 10 0 0 +11 A 10 12 0 11 0 12 +12 T 11 13 26 12 11 13 +13 G 12 14 25 13 12 0 +14 G 13 15 0 14 0 0 +15 C 14 16 23 15 0 16 +16 A 15 17 22 16 15 0 +17 T 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 G 20 22 0 21 0 0 +22 T 21 23 16 22 0 23 +23 G 22 24 15 23 22 0 +24 A 23 25 0 24 0 0 +25 C 24 26 13 25 0 26 +26 A 25 27 12 26 25 0 +27 G 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 T 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 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pos=16:66143845-66143885 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 10 +10 G 9 11 20 10 9 11 +11 A 10 12 19 11 10 12 +12 T 11 13 18 12 11 13 +13 T 12 14 17 13 12 0 +14 G 13 15 0 14 0 0 +15 G 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 A 16 18 13 17 0 18 +18 A 17 19 12 18 17 19 +19 T 18 20 11 19 18 20 +20 C 19 21 10 20 19 21 +21 C 20 22 0 21 20 0 +22 A 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 G 24 26 0 25 0 0 +26 T 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 T 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 C 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -1.831 candidate_21875958 pos=16:43193506-43193546 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 5 +5 C 4 6 14 5 4 6 +6 A 5 7 13 6 5 7 +7 A 6 8 12 7 6 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 G 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 T 11 13 7 12 0 13 +13 T 12 14 6 13 12 14 +14 G 13 15 5 14 13 15 +15 G 14 16 0 15 14 0 +16 G 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 G 18 20 0 19 0 20 +20 C 19 21 38 20 19 21 +21 A 20 22 37 21 20 22 +22 C 21 23 36 22 21 23 +23 T 22 24 35 23 22 0 +24 G 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 G 25 27 0 26 0 0 +27 T 26 28 0 27 0 0 +28 T 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 A 34 36 23 35 0 36 +36 G 35 37 22 36 35 37 +37 T 36 38 21 37 36 38 +38 G 37 39 20 38 37 39 +39 G 38 40 0 39 38 0 +40 G 39 0 0 40 0 0 +40 dG = -2.156 candidate_21877901 pos=16:35139947-35139987 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 4 +4 A 3 5 35 4 3 5 +5 C 4 6 34 5 4 6 +6 A 5 7 33 6 5 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 30 9 0 10 +10 G 9 11 29 10 9 11 +11 C 10 12 28 11 10 12 +12 A 11 13 27 12 11 0 +13 A 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 G 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 G 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 G 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 T 26 28 12 27 0 28 +28 G 27 29 11 28 27 29 +29 C 28 30 10 29 28 30 +30 T 29 31 9 30 29 0 +31 A 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 T 32 34 6 33 0 34 +34 G 33 35 5 34 33 35 +35 T 34 36 4 35 34 36 +36 G 35 37 0 36 35 0 +37 A 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = 2.074 candidate_21880075 pos=16:92131398-92131438 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 G 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 G 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 C 24 26 0 25 0 26 +26 A 25 27 33 26 25 27 +27 T 26 28 32 27 26 0 +28 C 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 A 31 33 27 32 0 33 +33 T 32 34 26 33 32 34 +34 C 33 35 0 34 33 0 +35 A 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -3.348 candidate_21880288 pos=16:68164199-68164239 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 G 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 G 13 15 0 14 0 0 +15 G 14 16 0 15 0 16 +16 C 15 17 38 16 15 17 +17 T 16 18 37 17 16 18 +18 G 17 19 36 18 17 19 +19 T 18 20 35 19 18 20 +20 T 19 21 34 20 19 21 +21 G 20 22 33 21 20 0 +22 A 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 C 25 27 0 26 0 0 +27 C 26 28 0 27 0 0 +28 T 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 G 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 C 32 34 21 33 0 34 +34 A 33 35 20 34 33 35 +35 A 34 36 19 35 34 36 +36 C 35 37 18 36 35 37 +37 A 36 38 17 37 36 38 +38 G 37 39 16 38 37 39 +39 T 38 40 0 39 38 0 +40 A 39 0 0 40 0 0 +40 dG = -2.038 candidate_21881395 pos=16:39190074-39190114 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 G 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 A 11 13 0 12 0 13 +13 C 12 14 29 13 12 14 +14 T 13 15 28 14 13 15 +15 C 14 16 27 15 14 16 +16 T 15 17 26 16 15 17 +17 A 16 18 25 17 16 18 +18 A 17 19 24 18 17 0 +19 G 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 G 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 T 23 25 18 24 0 25 +25 T 24 26 17 25 24 26 +26 A 25 27 16 26 25 27 +27 G 26 28 15 27 26 28 +28 G 27 29 14 28 27 29 +29 G 28 30 13 29 28 30 +30 A 29 31 0 30 29 0 +31 G 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 G 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = 0.334 candidate_21882598 pos=16:20162935-20162975 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 G 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 T 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 T 19 21 0 20 0 21 +21 C 20 22 28 21 20 22 +22 A 21 23 27 22 21 0 +23 G 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 C 25 27 0 26 0 0 +27 T 26 28 22 27 0 28 +28 G 27 29 21 28 27 29 +29 T 28 30 0 29 28 0 +30 C 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 C 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -2.546 candidate_21883244 pos=16:96178942-96178982 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 3 +3 A 2 4 32 3 2 4 +4 A 3 5 31 4 3 5 +5 C 4 6 30 5 4 6 +6 A 5 7 29 6 5 7 +7 A 6 8 28 7 6 0 +8 A 7 9 23 8 0 9 +9 A 8 10 22 9 8 10 +10 G 9 11 21 10 9 11 +11 C 10 12 20 11 10 0 +12 A 11 13 0 12 0 0 +13 T 12 14 0 13 0 0 +14 G 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 T 15 17 0 16 0 0 +17 T 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 G 18 20 0 19 0 0 +20 G 19 21 11 20 0 21 +21 C 20 22 10 21 20 22 +22 T 21 23 9 22 21 23 +23 T 22 24 8 23 22 0 +24 A 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 G 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 T 27 29 7 28 0 29 +29 T 28 30 6 29 28 30 +30 G 29 31 5 30 29 31 +31 T 30 32 4 31 30 32 +32 T 31 33 3 32 31 33 +33 G 32 34 0 33 32 0 +34 G 33 35 0 34 0 0 +35 C 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -5.968 candidate_21883970 pos=16:33164535-33164575 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 G 9 11 0 10 0 11 +11 C 10 12 26 11 10 12 +12 C 11 13 25 12 11 13 +13 A 12 14 24 13 12 14 +14 A 13 15 23 14 13 15 +15 C 14 16 22 15 14 16 +16 C 15 17 21 16 15 0 +17 T 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 G 19 21 0 20 0 0 +21 G 20 22 16 21 0 22 +22 G 21 23 15 22 21 23 +23 T 22 24 14 23 22 24 +24 T 23 25 13 24 23 25 +25 G 24 26 12 25 24 26 +26 G 25 27 11 26 25 27 +27 A 26 28 0 27 26 0 +28 G 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -1.884 candidate_21884557 pos=16:65100610-65100650 +1 A 0 2 0 1 0 2 +2 A 1 3 22 2 1 3 +3 A 2 4 21 3 2 4 +4 A 3 5 20 4 3 5 +5 C 4 6 19 5 4 6 +6 A 5 7 18 6 5 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 G 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 C 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 G 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 C 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 T 17 19 6 18 0 19 +19 G 18 20 5 19 18 20 +20 T 19 21 4 20 19 21 +21 T 20 22 3 21 20 22 +22 T 21 23 2 22 21 23 +23 C 22 24 0 23 22 0 +24 C 23 25 0 24 0 25 +25 C 24 26 35 25 24 26 +26 T 25 27 34 26 25 27 +27 G 26 28 33 27 26 0 +28 A 27 29 0 28 0 0 +29 T 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 C 32 34 27 33 0 34 +34 A 33 35 26 34 33 35 +35 G 34 36 25 35 34 36 +36 T 35 37 0 36 35 0 +37 T 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -0.409 candidate_21884633 pos=16:5196409-5196449 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 G 9 11 0 10 0 11 +11 C 10 12 31 11 10 12 +12 C 11 13 30 12 11 13 +13 A 12 14 29 13 12 0 +14 G 13 15 0 14 0 0 +15 G 14 16 0 15 0 0 +16 C 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 G 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 G 21 23 0 22 0 0 +23 G 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 C 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 T 27 29 0 28 0 0 +29 T 28 30 13 29 0 30 +30 G 29 31 12 30 29 31 +31 G 30 32 11 31 30 32 +32 A 31 33 0 32 31 0 +33 A 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -0.109 candidate_21884867 pos=16:73131946-73131986 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 G 9 11 0 10 0 11 +11 C 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0 0 +17 T 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 G 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 T 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 T 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 T 33 35 8 34 0 35 +35 T 34 36 7 35 34 36 +36 T 35 37 6 36 35 37 +37 G 36 38 5 37 36 38 +38 T 37 39 4 38 37 39 +39 G 38 40 0 39 38 0 +40 T 39 0 0 40 0 0 +40 dG = -3.304 candidate_21887125 pos=16:51197616-51197656 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 G 9 11 0 10 0 11 +11 C 10 12 40 11 10 12 +12 T 11 13 39 12 11 13 +13 A 12 14 38 13 12 14 +14 C 13 15 37 14 13 15 +15 A 14 16 36 15 14 16 +16 T 15 17 35 16 15 17 +17 G 16 18 34 17 16 0 +18 G 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 G 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 T 22 24 0 23 0 0 +24 G 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 T 25 27 0 26 0 0 +27 C 26 28 0 27 0 0 +28 T 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 C 33 35 17 34 0 35 +35 A 34 36 16 35 34 36 +36 T 35 37 15 36 35 37 +37 G 36 38 14 37 36 38 +38 T 37 39 13 38 37 39 +39 A 38 40 12 39 38 40 +40 G 39 0 11 40 39 0 +40 dG = -0.562 candidate_21888142 pos=16:57184506-57184546 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 G 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 T 11 13 0 12 0 13 +13 G 12 14 31 13 12 14 +14 C 13 15 30 14 13 15 +15 A 14 16 29 15 14 16 +16 A 15 17 0 16 15 0 +17 T 16 18 0 17 0 18 +18 A 17 19 25 18 17 19 +19 G 18 20 24 19 18 0 +20 G 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 G 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 C 23 25 19 24 0 25 +25 T 24 26 18 25 24 26 +26 C 25 27 0 26 25 0 +27 T 26 28 0 27 0 0 +28 C 27 29 0 28 0 29 +29 T 28 30 15 29 28 30 +30 G 29 31 14 30 29 31 +31 C 30 32 13 31 30 32 +32 C 31 33 0 32 31 0 +33 A 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -2.936 candidate_21888583 pos=16:8147690-8147730 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 9 +9 A 8 10 40 9 8 10 +10 G 9 11 39 10 9 11 +11 C 10 12 38 11 10 12 +12 T 11 13 37 12 11 13 +13 G 12 14 36 13 12 0 +14 T 13 15 0 14 0 0 +15 G 14 16 33 15 0 16 +16 T 15 17 32 16 15 17 +17 G 16 18 31 17 16 0 +18 A 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 G 24 26 0 25 0 0 +26 T 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 C 30 32 17 31 0 32 +32 A 31 33 16 32 31 33 +33 C 32 34 15 33 32 0 +34 T 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 C 35 37 13 36 0 37 +37 A 36 38 12 37 36 38 +38 G 37 39 11 38 37 39 +39 C 38 40 10 39 38 40 +40 T 39 0 9 40 39 0 +40 dG = -2.312 candidate_21890845 pos=16:61173693-61173733 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 G 9 11 0 10 0 0 +11 G 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 G 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 A 16 18 0 17 0 18 +18 C 17 19 30 18 17 19 +19 A 18 20 29 19 18 20 +20 C 19 21 28 20 19 21 +21 A 20 22 27 21 20 0 +22 A 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 C 25 27 0 26 0 0 +27 T 26 28 21 27 0 28 +28 G 27 29 20 28 27 29 +29 T 28 30 19 29 28 30 +30 G 29 31 18 30 29 31 +31 G 30 32 0 31 30 0 +32 A 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 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= -1.062 candidate_21891758 pos=16:90196260-90196300 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 G 9 11 0 10 0 0 +11 G 10 12 0 11 0 0 +12 A 11 13 0 12 0 13 +13 C 12 14 21 13 12 14 +14 A 13 15 20 14 13 0 +15 A 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 T 18 20 0 19 0 0 +20 T 19 21 14 20 0 21 +21 G 20 22 13 21 20 22 +22 A 21 23 0 22 21 0 +23 C 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 G 24 26 0 25 0 0 +26 C 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 T 27 29 0 28 0 29 +29 C 28 30 37 29 28 30 +30 C 29 31 36 30 29 0 +31 A 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 G 35 37 30 36 0 37 +37 G 36 38 29 37 36 38 +38 G 37 39 0 38 37 0 +39 A 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -0.622 candidate_21892971 pos=16:25169626-25169666 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 G 9 11 0 10 0 0 +11 G 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 G 12 14 0 13 0 0 +14 G 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 G 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 G 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 G 21 23 0 22 0 23 +23 A 22 24 34 23 22 24 +24 A 23 25 33 24 23 25 +25 T 24 26 32 25 24 26 +26 T 25 27 31 26 25 0 +27 A 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 A 30 32 26 31 0 32 +32 A 31 33 25 32 31 33 +33 T 32 34 24 33 32 34 +34 T 33 35 23 34 33 35 +35 G 34 36 0 35 34 0 +36 A 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -3.226 candidate_21893541 pos=16:96106024-96106064 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 5 +5 C 4 6 20 5 4 6 +6 A 5 7 19 6 5 0 +7 A 6 8 0 7 0 0 +8 A 7 9 17 8 0 9 +9 A 8 10 16 9 8 10 +10 G 9 11 15 10 9 0 +11 G 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 T 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 C 14 16 10 15 0 16 +16 T 15 17 9 16 15 17 +17 T 16 18 8 17 16 0 +18 A 17 19 0 18 0 0 +19 T 18 20 6 19 0 20 +20 G 19 21 5 20 19 21 +21 G 20 22 0 21 20 0 +22 G 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 G 24 26 0 25 0 0 +26 G 25 27 0 26 0 0 +27 G 26 28 0 27 0 28 +28 G 27 29 37 28 27 29 +29 A 28 30 36 29 28 30 +30 G 29 31 35 30 29 0 +31 A 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 C 34 36 30 35 0 36 +36 T 35 37 29 36 35 37 +37 C 36 38 28 37 36 38 +38 A 37 39 0 38 37 0 +39 T 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -2.042 candidate_21894666 pos=16:19131189-19131229 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 8 +8 A 7 9 20 8 7 9 +9 A 8 10 19 9 8 10 +10 G 9 11 18 10 9 11 +11 G 10 12 17 11 10 0 +12 A 11 13 0 12 0 0 +13 T 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 T 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 C 16 18 11 17 0 18 +18 C 17 19 10 18 17 19 +19 T 18 20 9 19 18 20 +20 T 19 21 8 20 19 21 +21 C 20 22 0 21 20 0 +22 T 21 23 0 22 0 0 +23 T 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 C 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -3.608 candidate_21896771 pos=16:4154836-4154876 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 8 +8 A 7 9 17 8 7 9 +9 A 8 10 16 9 8 10 +10 G 9 11 15 10 9 0 +11 G 10 12 0 11 0 0 +12 C 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 C 14 16 10 15 0 16 +16 T 15 17 9 16 15 17 +17 T 16 18 8 17 16 18 +18 A 17 19 0 18 17 0 +19 C 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 T 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 G 27 29 0 28 0 29 +29 C 28 30 38 29 28 30 +30 A 29 31 37 30 29 31 +31 C 30 32 36 31 30 0 +32 A 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 G 35 37 31 36 0 37 +37 T 36 38 30 37 36 38 +38 G 37 39 29 38 37 39 +39 A 38 40 0 39 38 0 +40 C 39 0 0 40 0 0 +40 dG = -0.542 candidate_21897548 pos=16:91199660-91199700 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 8 +8 A 7 9 26 8 7 9 +9 A 8 10 25 9 8 10 +10 G 9 11 24 10 9 11 +11 G 10 12 23 11 10 0 +12 C 11 13 0 12 0 0 +13 C 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 T 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 C 22 24 11 23 0 24 +24 C 23 25 10 24 23 25 +25 T 24 26 9 25 24 26 +26 T 25 27 8 26 25 27 +27 C 26 28 0 27 26 0 +28 T 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -2.152 candidate_21898022 pos=16:5142581-5142621 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 8 +8 A 7 9 19 8 7 9 +9 A 8 10 18 9 8 10 +10 G 9 11 17 10 9 11 +11 G 10 12 16 11 10 0 +12 C 11 13 0 12 0 0 +13 T 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 G 14 16 0 15 0 0 +16 C 15 17 11 16 0 17 +17 C 16 18 10 17 16 18 +18 T 17 19 9 18 17 19 +19 T 18 20 8 19 18 20 +20 G 19 21 0 20 19 0 +21 G 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 T 22 24 0 23 0 0 +24 G 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 T 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 C 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -1.988 candidate_21902275 pos=16:97126580-97126620 +1 A 0 2 15 1 0 2 +2 A 1 3 14 2 1 3 +3 A 2 4 13 3 2 4 +4 A 3 5 12 4 3 5 +5 C 4 6 11 5 4 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 G 9 11 0 10 0 0 +11 G 10 12 5 11 0 12 +12 T 11 13 4 12 11 13 +13 T 12 14 3 13 12 14 +14 T 13 15 2 14 13 15 +15 T 14 16 1 15 14 16 +16 A 15 17 0 16 15 0 +17 C 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 G 21 23 0 22 0 0 +23 T 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 C 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 G 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 T 36 38 0 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pos=16:11192920-11192960 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 G 9 11 0 10 0 0 +11 T 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 G 12 14 0 13 0 0 +14 T 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 A 15 17 0 16 0 17 +17 G 16 18 34 17 16 18 +18 G 17 19 33 18 17 19 +19 T 18 20 32 19 18 0 +20 G 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 G 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 G 24 26 0 25 0 0 +26 T 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 A 31 33 19 32 0 33 +33 C 32 34 18 33 32 34 +34 C 33 35 17 34 33 35 +35 A 34 36 0 35 34 0 +36 A 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -3.688 candidate_21909049 pos=16:17189854-17189894 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 8 +8 A 7 9 36 8 7 9 +9 A 8 10 35 9 8 0 +10 G 9 11 0 10 0 0 +11 T 10 12 33 11 0 12 +12 G 11 13 32 12 11 0 +13 G 12 14 0 13 0 0 +14 T 13 15 30 14 0 15 +15 G 14 16 29 15 14 16 +16 A 15 17 28 16 15 17 +17 G 16 18 27 17 16 0 +18 G 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 G 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 G 24 26 0 25 0 0 +26 G 25 27 0 26 0 0 +27 C 26 28 17 27 0 28 +28 T 27 29 16 28 27 29 +29 C 28 30 15 29 28 30 +30 A 29 31 14 30 29 0 +31 A 30 32 0 31 0 0 +32 C 31 33 12 32 0 33 +33 A 32 34 11 33 32 0 +34 G 33 35 0 34 0 0 +35 T 34 36 9 35 0 36 +36 T 35 37 8 36 35 37 +37 A 36 38 0 37 36 0 +38 A 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -1.202 candidate_21909100 pos=16:22147477-22147517 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 10 +10 G 9 11 31 10 9 11 +11 T 10 12 30 11 10 12 +12 G 11 13 29 12 11 13 +13 T 12 14 28 13 12 0 +14 A 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 G 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 G 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 A 27 29 13 28 0 29 +29 C 28 30 12 29 28 30 +30 A 29 31 11 30 29 31 +31 C 30 32 10 31 30 32 +32 A 31 33 0 32 31 0 +33 G 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -0.236 candidate_21911224 pos=16:21183507-21183547 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 5 +5 C 4 6 13 5 4 6 +6 A 5 7 12 6 5 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 G 9 11 0 10 0 0 +11 T 10 12 0 11 0 0 +12 T 11 13 6 12 0 13 +13 G 12 14 5 13 12 14 +14 G 13 15 0 14 13 0 +15 T 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 G 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 G 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 G 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 T 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 G 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -1.722 candidate_21915805 pos=16:6147626-6147666 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 T 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 20 +20 C 19 21 34 20 19 21 +21 C 20 22 33 21 20 22 +22 A 21 23 32 22 21 23 +23 T 22 24 31 23 22 0 +24 G 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 A 30 32 23 31 0 32 +32 T 31 33 22 32 31 33 +33 G 32 34 21 33 32 34 +34 G 33 35 20 34 33 35 +35 A 34 36 0 35 34 0 +36 T 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = 0.384 candidate_21920282 pos=16:32187546-32187586 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 T 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 G 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 G 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 A 23 25 0 24 0 25 +25 G 24 26 38 25 24 26 +26 C 25 27 37 26 25 0 +27 A 26 28 0 27 0 0 +28 T 27 29 0 28 0 0 +29 T 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 G 36 38 26 37 0 38 +38 C 37 39 25 38 37 39 +39 C 38 40 0 39 38 0 +40 C 39 0 0 40 0 0 +40 dG = -1.332 candidate_21924434 pos=16:72152772-72152812 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 T 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 13 +13 C 12 14 33 13 12 14 +14 C 13 15 32 14 13 15 +15 A 14 16 31 15 14 16 +16 G 15 17 30 16 15 0 +17 T 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 G 21 23 0 22 0 0 +23 T 22 24 0 23 0 0 +24 G 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 C 25 27 0 26 0 0 +27 T 26 28 0 27 0 0 +28 T 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 C 29 31 16 30 0 31 +31 T 30 32 15 31 30 32 +32 G 31 33 14 32 31 33 +33 G 32 34 13 33 32 34 +34 C 33 35 0 34 33 0 +35 T 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -0.439 candidate_21925638 pos=16:24143294-24143334 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 T 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 G 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 T 14 16 0 15 0 16 +16 G 15 17 26 16 15 17 +17 G 16 18 25 17 16 18 +18 T 17 19 24 18 17 0 +19 G 18 20 0 19 0 0 +20 G 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 T 22 24 0 23 0 0 +24 G 23 25 18 24 0 25 +25 C 24 26 17 25 24 26 +26 C 25 27 16 26 25 27 +27 T 26 28 0 27 26 0 +28 T 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 G 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -2.154 candidate_21939090 pos=16:28155420-28155460 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 T 9 11 0 10 0 0 +11 A 10 12 0 11 0 12 +12 T 11 13 22 12 11 13 +13 G 12 14 21 13 12 14 +14 C 13 15 20 14 13 0 +15 T 14 16 0 15 0 0 +16 C 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 G 17 19 0 18 0 0 +19 T 18 20 0 19 0 0 +20 G 19 21 14 20 0 21 +21 C 20 22 13 21 20 22 +22 A 21 23 12 22 21 0 +23 A 22 24 0 23 0 24 +24 A 23 25 38 24 23 25 +25 C 24 26 37 25 24 26 +26 C 25 27 36 26 25 27 +27 T 26 28 35 27 26 0 +28 C 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 G 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 A 34 36 27 35 0 36 +36 G 35 37 26 36 35 37 +37 G 36 38 25 37 36 38 +38 T 37 39 24 38 37 39 +39 C 38 40 0 39 38 0 +40 A 39 0 0 40 0 0 +40 dG = 0.131 candidate_21943614 pos=16:78146038-78146078 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 T 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 G 13 15 0 14 0 0 +15 A 14 16 0 15 0 16 +16 C 15 17 38 16 15 17 +17 T 16 18 37 17 16 0 +18 A 17 19 0 18 0 0 +19 C 18 20 35 19 0 20 +20 A 19 21 34 20 19 0 +21 G 20 22 0 21 0 0 +22 C 21 23 31 22 0 23 +23 A 22 24 30 23 22 0 +24 G 23 25 0 24 0 0 +25 G 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 T 29 31 23 30 0 31 +31 G 30 32 22 31 30 0 +32 G 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 T 33 35 20 34 0 35 +35 G 34 36 19 35 34 0 +36 G 35 37 0 36 0 0 +37 A 36 38 17 37 0 38 +38 G 37 39 16 38 37 39 +39 G 38 40 0 39 38 0 +40 T 39 0 0 40 0 0 +40 dG = 0.308 candidate_21945865 pos=16:28149023-28149063 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 T 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 G 12 14 0 13 0 0 +14 G 13 15 0 14 0 0 +15 G 14 16 0 15 0 0 +16 G 15 17 0 16 0 0 +17 T 16 18 37 17 0 18 +18 G 17 19 36 18 17 19 +19 C 18 20 35 19 18 0 +20 T 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 T 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 G 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 G 34 36 19 35 0 36 +36 C 35 37 18 36 35 37 +37 A 36 38 17 37 36 38 +38 A 37 39 0 38 37 0 +39 T 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -0.316 candidate_21951625 pos=16:91185437-91185477 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 T 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 T 11 13 0 12 0 0 +13 C 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 C 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 A 24 26 0 25 0 26 +26 G 25 27 34 26 25 27 +27 C 26 28 33 27 26 0 +28 C 27 29 0 28 0 0 +29 T 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 G 32 34 27 33 0 34 +34 C 33 35 26 34 33 35 +35 C 34 36 0 35 34 0 +36 T 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -1.602 candidate_21951703 pos=16:54143955-54143995 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 T 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 T 11 13 0 12 0 0 +13 C 12 14 0 13 0 14 +14 A 13 15 26 14 13 15 +15 C 14 16 25 15 14 16 +16 A 15 17 24 16 15 17 +17 G 16 18 23 17 16 0 +18 C 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 C 22 24 17 23 0 24 +24 T 23 25 16 24 23 25 +25 G 24 26 15 25 24 26 +26 T 25 27 14 26 25 27 +27 C 26 28 0 27 26 0 +28 C 27 29 0 28 0 0 +29 T 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -0.606 candidate_21951872 pos=16:10129152-10129192 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 T 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 T 11 13 0 12 0 0 +13 C 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 T 14 16 0 15 0 0 +16 G 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 G 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 C 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 G 27 29 0 28 0 29 +29 G 28 30 37 29 28 30 +30 C 29 31 36 30 29 0 +31 C 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 G 35 37 30 36 0 37 +37 C 36 38 29 37 36 38 +38 T 37 39 0 38 37 0 +39 G 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = 0.434 candidate_21955055 pos=16:28167909-28167949 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 5 +5 C 4 6 11 5 4 6 +6 A 5 7 10 6 5 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 T 9 11 6 10 0 11 +11 G 10 12 5 11 10 12 +12 A 11 13 0 12 11 0 +13 A 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 G 23 25 0 24 0 0 +25 G 24 26 0 25 0 0 +26 T 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 T 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 G 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -2.782 candidate_21956780 pos=16:91182411-91182451 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 T 9 11 0 10 0 0 +11 G 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 14 +14 G 13 15 39 14 13 15 +15 C 14 16 38 15 14 16 +16 C 15 17 37 16 15 17 +17 A 16 18 36 17 16 0 +18 G 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 G 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 A 24 26 35 25 0 26 +26 C 25 27 34 26 25 27 +27 A 26 28 33 27 26 28 +28 C 27 29 32 28 27 0 +29 A 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 G 31 33 28 32 0 33 +33 T 32 34 27 33 32 34 +34 G 33 35 26 34 33 35 +35 T 34 36 25 35 34 0 +36 T 35 37 17 36 0 37 +37 G 36 38 16 37 36 38 +38 G 37 39 15 38 37 39 +39 C 38 40 14 39 38 40 +40 A 39 0 0 40 39 0 +40 dG = -2.082 candidate_21958297 pos=16:50115922-50115962 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 T 9 11 0 10 0 0 +11 G 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 G 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 A 14 16 0 15 0 16 +16 A 15 17 35 16 15 17 +17 G 16 18 34 17 16 18 +18 G 17 19 33 18 17 19 +19 C 18 20 32 19 18 0 +20 G 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 G 21 23 0 22 0 0 +23 G 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 G 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 G 31 33 19 32 0 33 +33 C 32 34 18 33 32 34 +34 C 33 35 17 34 33 35 +35 T 34 36 16 35 34 36 +36 C 35 37 0 36 35 0 +37 C 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -3.425 candidate_21959123 pos=16:17100947-17100987 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 T 9 11 0 10 0 0 +11 G 10 12 0 11 0 12 +12 A 11 13 26 12 11 13 +13 G 12 14 25 13 12 14 +14 T 13 15 24 14 13 15 +15 G 14 16 23 15 14 16 +16 T 15 17 22 16 15 0 +17 G 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 A 21 23 16 22 0 23 +23 C 22 24 15 23 22 24 +24 A 23 25 14 24 23 25 +25 C 24 26 13 25 24 26 +26 T 25 27 12 26 25 27 +27 A 26 28 0 27 26 0 +28 G 27 29 0 28 0 0 +29 T 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 G 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -1.865 candidate_21961679 pos=16:83169237-83169277 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 T 9 11 0 10 0 0 +11 G 10 12 0 11 0 0 +12 C 11 13 0 12 0 13 +13 C 12 14 32 13 12 14 +14 T 13 15 31 14 13 15 +15 T 14 16 30 15 14 16 +16 C 15 17 29 16 15 17 +17 T 16 18 28 17 16 0 +18 A 17 19 0 18 0 0 +19 T 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 T 25 27 0 26 0 0 +27 C 26 28 0 27 0 0 +28 A 27 29 17 28 0 29 +29 G 28 30 16 29 28 30 +30 A 29 31 15 30 29 31 +31 A 30 32 14 31 30 32 +32 G 31 33 13 32 31 33 +33 A 32 34 0 33 32 0 +34 C 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -3.118 candidate_21961983 pos=16:80154036-80154076 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 T 9 11 0 10 0 0 +11 G 10 12 0 11 0 0 +12 C 11 13 0 12 0 0 +13 T 12 14 0 13 0 14 +14 C 13 15 23 14 13 15 +15 A 14 16 22 15 14 16 +16 C 15 17 21 16 15 0 +17 A 16 18 0 17 0 0 +18 G 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 G 19 21 0 20 0 0 +21 G 20 22 16 21 0 22 +22 T 21 23 15 22 21 23 +23 G 22 24 14 23 22 24 +24 A 23 25 0 24 23 0 +25 A 24 26 0 25 0 0 +26 G 25 27 0 26 0 27 +27 G 26 28 37 27 26 28 +28 T 27 29 36 28 27 29 +29 G 28 30 35 29 28 0 +30 A 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 C 34 36 29 35 0 36 +36 A 35 37 28 36 35 37 +37 C 36 38 27 37 36 38 +38 A 37 39 0 38 37 0 +39 A 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = 0.331 candidate_21966751 pos=16:37129884-37129924 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 4 +4 A 3 5 12 4 3 5 +5 C 4 6 11 5 4 6 +6 A 5 7 10 6 5 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 T 9 11 6 10 0 11 +11 G 10 12 5 11 10 12 +12 T 11 13 4 12 11 13 +13 C 12 14 0 13 12 0 +14 C 13 15 0 14 0 0 +15 G 14 16 0 15 0 0 +16 T 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 T 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 T 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 T 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 G 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -3.848 candidate_21967395 pos=16:58168778-58168818 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 10 +10 T 9 11 23 10 9 11 +11 G 10 12 22 11 10 12 +12 T 11 13 21 12 11 13 +13 G 12 14 20 13 12 14 +14 C 13 15 19 14 13 0 +15 C 14 16 0 15 0 0 +16 T 15 17 0 16 0 0 +17 T 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 G 18 20 14 19 0 20 +20 C 19 21 13 20 19 21 +21 A 20 22 12 21 20 22 +22 C 21 23 11 22 21 23 +23 A 22 24 10 23 22 0 +24 G 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 G 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 G 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -2.017 candidate_21968283 pos=16:18109528-18109568 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 T 9 11 0 10 0 0 +11 G 10 12 0 11 0 0 +12 T 11 13 0 12 0 0 +13 T 12 14 0 13 0 14 +14 C 13 15 32 14 13 15 +15 C 14 16 31 15 14 16 +16 T 15 17 30 16 15 0 +17 C 16 18 0 17 0 0 +18 T 17 19 27 18 0 19 +19 G 18 20 26 19 18 20 +20 G 19 21 25 20 19 0 +21 T 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 T 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 C 24 26 20 25 0 26 +26 C 25 27 19 26 25 27 +27 A 26 28 18 27 26 0 +28 A 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 A 29 31 16 30 0 31 +31 G 30 32 15 31 30 32 +32 G 31 33 14 32 31 33 +33 C 32 34 0 33 32 0 +34 T 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -2.007 candidate_21972372 pos=16:48194702-48194742 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 T 9 11 0 10 0 0 +11 T 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 G 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 G 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 20 +20 G 19 21 39 20 19 21 +21 G 20 22 38 21 20 0 +22 A 21 23 0 22 0 0 +23 C 22 24 36 23 0 24 +24 A 23 25 35 24 23 25 +25 T 24 26 34 25 24 0 +26 G 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 A 33 35 25 34 0 35 +35 T 34 36 24 35 34 36 +36 G 35 37 23 36 35 0 +37 G 36 38 0 37 0 0 +38 C 37 39 21 38 0 39 +39 C 38 40 20 39 38 40 +40 A 39 0 0 40 39 0 +40 dG = -2.153 candidate_21973007 pos=16:47167787-47167827 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 T 9 11 0 10 0 0 +11 T 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 T 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 A 14 16 0 15 0 16 +16 C 15 17 35 16 15 17 +17 A 16 18 34 17 16 18 +18 C 17 19 33 18 17 0 +19 T 18 20 0 19 0 0 +20 G 19 21 31 20 0 21 +21 G 20 22 30 21 20 22 +22 G 21 23 29 22 21 23 +23 T 22 24 28 23 22 0 +24 C 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 T 25 27 0 26 0 0 +27 T 26 28 0 27 0 0 +28 A 27 29 23 28 0 29 +29 T 28 30 22 29 28 30 +30 C 29 31 21 30 29 31 +31 C 30 32 20 31 30 0 +32 T 31 33 0 32 0 0 +33 G 32 34 18 33 0 34 +34 T 33 35 17 34 33 35 +35 G 34 36 16 35 34 36 +36 C 35 37 0 36 35 0 +37 T 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -2.078 candidate_21978114 pos=16:63152879-63152919 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 T 9 11 0 10 0 0 +11 T 10 12 0 11 0 12 +12 G 11 13 20 12 11 13 +13 A 12 14 19 13 12 14 +14 G 13 15 18 14 13 0 +15 G 14 16 0 15 0 0 +16 G 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 C 17 19 14 18 0 19 +19 T 18 20 13 19 18 20 +20 C 19 21 12 20 19 21 +21 C 20 22 0 21 20 0 +22 A 21 23 0 22 0 0 +23 G 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 T 25 27 0 26 0 0 +27 A 26 28 0 27 0 28 +28 C 27 29 39 28 27 29 +29 A 28 30 38 29 28 30 +30 G 29 31 37 30 29 0 +31 A 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 G 35 37 0 36 0 0 +37 C 36 38 30 37 0 38 +38 T 37 39 29 38 37 39 +39 G 38 40 28 39 38 40 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0 0 +10 T 9 11 0 10 0 0 +11 T 10 12 0 11 0 0 +12 T 11 13 0 12 0 0 +13 C 12 14 0 13 0 0 +14 T 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 C 15 17 0 16 0 0 +17 C 16 18 0 17 0 18 +18 C 17 19 34 18 17 19 +19 A 18 20 33 19 18 20 +20 C 19 21 32 20 19 21 +21 T 20 22 31 21 20 0 +22 A 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 C 25 27 0 26 0 0 +27 C 26 28 0 27 0 0 +28 T 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 A 30 32 21 31 0 32 +32 G 31 33 20 32 31 33 +33 T 32 34 19 33 32 34 +34 G 33 35 18 34 33 35 +35 A 34 36 0 35 34 0 +36 C 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -0.785 candidate_21982954 pos=16:86199584-86199624 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 5 +5 C 4 6 13 5 4 6 +6 A 5 7 12 6 5 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 T 9 11 0 10 0 0 +11 T 10 12 0 11 0 0 +12 T 11 13 6 12 0 13 +13 G 12 14 5 13 12 14 +14 C 13 15 0 14 13 0 +15 A 14 16 0 15 0 16 +16 A 15 17 31 16 15 17 +17 G 16 18 30 17 16 18 +18 C 17 19 29 18 17 0 +19 A 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 G 22 24 0 23 0 0 +24 G 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 T 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 G 28 30 18 29 0 30 +30 C 29 31 17 30 29 31 +31 T 30 32 16 31 30 32 +32 G 31 33 0 32 31 0 +33 G 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -0.236 candidate_21983199 pos=16:19155514-19155554 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 5 +5 C 4 6 13 5 4 6 +6 A 5 7 12 6 5 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 T 9 11 0 10 0 0 +11 T 10 12 0 11 0 0 +12 T 11 13 6 12 0 13 +13 G 12 14 5 13 12 14 +14 G 13 15 0 14 13 0 +15 G 14 16 0 15 0 0 +16 T 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 G 17 19 0 18 0 0 +19 G 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 G 20 22 0 21 0 0 +22 G 21 23 0 22 0 0 +23 T 22 24 0 23 0 0 +24 G 23 25 0 24 0 0 +25 G 24 26 0 25 0 0 +26 G 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 G 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -0.469 candidate_22007903 pos=16:87129728-87129768 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 C 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 A 10 12 0 11 0 12 +12 A 11 13 22 12 11 13 +13 A 12 14 21 13 12 14 +14 C 13 15 20 14 13 0 +15 A 14 16 0 15 0 0 +16 C 15 17 0 16 0 0 +17 T 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 G 19 21 14 20 0 21 +21 T 20 22 13 21 20 22 +22 T 21 23 12 22 21 23 +23 C 22 24 0 23 22 0 +24 A 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 C 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = 0.471 candidate_22008965 pos=16:85166641-85166681 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 C 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 C 21 23 0 22 0 23 +23 A 22 24 33 23 22 24 +24 A 23 25 32 24 23 25 +25 A 24 26 31 25 24 0 +26 C 25 27 0 26 0 0 +27 C 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 T 30 32 25 31 0 32 +32 T 31 33 24 32 31 33 +33 T 32 34 23 33 32 34 +34 A 33 35 0 34 33 0 +35 C 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -1.372 candidate_22009936 pos=16:13198354-13198394 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 C 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 G 14 16 0 15 0 0 +16 G 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 G 21 23 0 22 0 23 +23 C 22 24 36 23 22 24 +24 A 23 25 35 24 23 25 +25 G 24 26 34 25 24 26 +26 A 25 27 33 26 25 0 +27 A 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 T 32 34 26 33 0 34 +34 C 33 35 25 34 33 35 +35 T 34 36 24 35 34 36 +36 G 35 37 23 36 35 37 +37 T 36 38 0 37 36 0 +38 A 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -0.442 candidate_22012273 pos=16:31196757-31196797 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 C 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 G 13 15 0 14 0 0 +15 T 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 T 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 C 19 21 0 20 0 21 +21 C 20 22 34 21 20 22 +22 C 21 23 33 22 21 23 +23 T 22 24 32 23 22 24 +24 A 23 25 31 24 23 0 +25 T 24 26 0 25 0 0 +26 C 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 T 30 32 24 31 0 32 +32 A 31 33 23 32 31 33 +33 G 32 34 22 33 32 34 +34 G 33 35 21 34 33 35 +35 T 34 36 0 35 34 0 +36 A 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = 0.331 candidate_22067700 pos=16:79178510-79178550 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 C 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 C 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 A 14 16 0 15 0 16 +16 A 15 17 24 16 15 17 +17 C 16 18 23 17 16 18 +18 A 17 19 22 18 17 0 +19 A 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 T 21 23 18 22 0 23 +23 G 22 24 17 23 22 24 +24 T 23 25 16 24 23 25 +25 C 24 26 0 25 24 0 +26 T 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 C 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = 0.491 candidate_22070025 pos=16:95161906-95161946 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 C 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 C 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 A 17 19 0 18 0 19 +19 G 18 20 39 19 18 20 +20 G 19 21 38 20 19 21 +21 A 20 22 37 21 20 0 +22 G 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 T 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 T 36 38 21 37 0 38 +38 C 37 39 20 38 37 39 +39 C 38 40 19 39 38 40 +40 C 39 0 0 40 39 0 +40 dG = 0.483 candidate_22070415 pos=16:60163443-60163483 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 C 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 C 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 T 18 20 0 19 0 0 +20 G 19 21 0 20 0 0 +21 G 20 22 0 21 0 0 +22 T 21 23 0 22 0 23 +23 C 22 24 39 23 22 24 +24 A 23 25 38 24 23 0 +25 G 24 26 0 25 0 0 +26 A 25 27 36 26 0 27 +27 A 26 28 35 27 26 28 +28 T 27 29 34 28 27 0 +29 G 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 G 33 35 28 34 0 35 +35 T 34 36 27 35 34 36 +36 T 35 37 26 36 35 0 +37 A 36 38 0 37 0 0 +38 T 37 39 24 38 0 39 +39 G 38 40 23 39 38 40 +40 G 39 0 0 40 39 0 +40 dG = -2.775 candidate_22072895 pos=16:11187568-11187608 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 C 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 13 +13 C 12 14 28 13 12 14 +14 A 13 15 27 14 13 15 +15 A 14 16 26 15 14 16 +16 A 15 17 25 16 15 17 +17 G 16 18 24 17 16 0 +18 A 17 19 0 18 0 0 +19 T 18 20 0 19 0 0 +20 G 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 G 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 C 23 25 17 24 0 25 +25 T 24 26 16 25 24 26 +26 T 25 27 15 26 25 27 +27 T 26 28 14 27 26 28 +28 G 27 29 13 28 27 29 +29 A 28 30 0 29 28 0 +30 A 29 31 0 30 0 0 +31 G 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -0.142 candidate_22077731 pos=16:67178091-67178131 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 C 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 C 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 G 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 T 26 28 0 27 0 0 +28 C 27 29 0 28 0 29 +29 C 28 30 40 29 28 30 +30 C 29 31 39 30 29 31 +31 A 30 32 38 31 30 0 +32 G 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 G 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 T 37 39 31 38 0 39 +39 G 38 40 30 39 38 40 +40 G 39 0 29 40 39 0 +40 dG = -2.535 candidate_22077881 pos=16:15134201-15134241 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 C 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 C 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 G 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 A 22 24 0 23 0 24 +24 A 23 25 39 24 23 25 +25 C 24 26 38 25 24 26 +26 T 25 27 37 26 25 27 +27 G 26 28 36 27 26 28 +28 T 27 29 35 28 27 0 +29 C 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 A 34 36 28 35 0 36 +36 C 35 37 27 36 35 37 +37 A 36 38 26 37 36 38 +38 G 37 39 25 38 37 39 +39 T 38 40 24 39 38 40 +40 G 39 0 0 40 39 0 +40 dG = -1.462 candidate_22080165 pos=16:12188710-12188750 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 C 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 C 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 G 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 T 23 25 0 24 0 25 +25 C 24 26 36 25 24 26 +26 C 25 27 35 26 25 27 +27 A 26 28 34 27 26 28 +28 T 27 29 33 28 27 0 +29 C 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 A 32 34 28 33 0 34 +34 T 33 35 27 34 33 35 +35 G 34 36 26 35 34 36 +36 G 35 37 25 36 35 37 +37 G 36 38 0 37 36 0 +38 T 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -0.705 candidate_22080497 pos=16:32111082-32111122 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 C 8 10 0 9 0 10 +10 A 9 11 39 10 9 11 +11 A 10 12 38 11 10 12 +12 A 11 13 37 12 11 13 +13 C 12 14 36 13 12 14 +14 A 13 15 35 14 13 0 +15 C 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 G 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 T 34 36 14 35 0 36 +36 G 35 37 13 36 35 37 +37 T 36 38 12 37 36 38 +38 T 37 39 11 38 37 39 +39 T 38 40 10 39 38 40 +40 A 39 0 0 40 39 0 +40 dG = 2.537 candidate_22080830 pos=16:64121803-64121843 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 C 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 C 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 C 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 G 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 G 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 G 25 27 0 26 0 0 +27 C 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 G 29 31 0 30 0 31 +31 C 30 32 39 31 30 0 +32 C 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 G 38 40 31 39 0 40 +40 T 39 0 0 40 39 0 +40 dG = -4.814 candidate_22082335 pos=16:50179734-50179774 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 8 +8 A 7 9 34 8 7 9 +9 C 8 10 33 9 8 10 +10 A 9 11 32 10 9 11 +11 A 10 12 31 11 10 12 +12 A 11 13 30 12 11 13 +13 C 12 14 29 13 12 14 +14 A 13 15 28 14 13 15 +15 G 14 16 0 15 14 0 +16 C 15 17 0 16 0 0 +17 A 16 18 0 17 0 18 +18 T 17 19 25 18 17 19 +19 G 18 20 24 19 18 0 +20 G 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 G 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 C 23 25 19 24 0 25 +25 A 24 26 18 25 24 26 +26 C 25 27 0 26 25 0 +27 A 26 28 0 27 0 28 +28 T 27 29 14 28 27 29 +29 G 28 30 13 29 28 30 +30 T 29 31 12 30 29 31 +31 T 30 32 11 31 30 32 +32 T 31 33 10 32 31 33 +33 G 32 34 9 33 32 34 +34 T 33 35 8 34 33 35 +35 A 34 36 0 35 34 0 +36 G 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = 0.424 candidate_22082778 pos=16:25112695-25112735 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 8 +8 A 7 9 16 8 7 9 +9 C 8 10 15 9 8 0 +10 A 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 C 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 G 14 16 9 15 0 16 +16 T 15 17 8 16 15 17 +17 C 16 18 0 17 16 0 +18 G 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -0.156 candidate_22083540 pos=16:30140025-30140065 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 C 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 C 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 T 14 16 0 15 0 0 +16 G 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 G 21 23 0 22 0 0 +23 T 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 A 25 27 0 26 0 27 +27 T 26 28 33 27 26 28 +28 C 27 29 32 28 27 0 +29 G 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 G 31 33 28 32 0 33 +33 A 32 34 27 33 32 34 +34 A 33 35 0 34 33 0 +35 A 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -1.949 candidate_22088458 pos=16:78160661-78160701 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 C 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 G 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 G 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 T 22 24 0 23 0 0 +24 G 23 25 0 24 0 25 +25 G 24 26 34 25 24 26 +26 C 25 27 33 26 25 27 +27 A 26 28 32 27 26 0 +28 A 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 T 31 33 27 32 0 33 +33 G 32 34 26 33 32 34 +34 C 33 35 25 34 33 35 +35 A 34 36 0 35 34 0 +36 G 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -1.989 candidate_22089455 pos=16:26154863-26154903 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 C 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 G 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 G 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 A 27 29 0 28 0 29 +29 C 28 30 39 29 28 30 +30 A 29 31 38 30 29 31 +31 G 30 32 37 31 30 0 +32 A 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 C 36 38 31 37 0 38 +38 T 37 39 30 38 37 39 +39 G 38 40 29 39 38 40 +40 A 39 0 0 40 39 0 +40 dG = -1.619 candidate_22090997 pos=16:51143275-51143315 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 C 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 G 12 14 0 13 0 0 +14 T 13 15 0 14 0 0 +15 T 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 T 17 19 0 18 0 19 +19 A 18 20 27 19 18 20 +20 A 19 21 26 20 19 21 +21 G 20 22 25 21 20 0 +22 G 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 C 24 26 21 25 0 26 +26 T 25 27 20 26 25 27 +27 T 26 28 19 27 26 28 +28 G 27 29 0 28 27 0 +29 T 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 C 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -0.526 candidate_22097738 pos=16:48156249-48156289 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 C 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 C 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 G 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 G 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 G 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 G 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 A 27 29 0 28 0 29 +29 A 28 30 35 29 28 30 +30 G 29 31 34 30 29 0 +31 G 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 C 33 35 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31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 T 33 35 29 34 0 35 +35 G 34 36 28 35 34 36 +36 G 35 37 27 36 35 37 +37 A 36 38 0 37 36 0 +38 G 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -0.486 candidate_22121522 pos=16:23101375-23101415 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 C 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 T 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 G 24 26 0 25 0 0 +26 T 25 27 0 26 0 27 +27 A 26 28 34 27 26 28 +28 C 27 29 33 28 27 0 +29 A 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 G 32 34 28 33 0 34 +34 T 33 35 27 34 33 35 +35 G 34 36 0 35 34 0 +36 C 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -0.945 candidate_22126700 pos=16:90130090-90130130 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 C 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 T 11 13 0 12 0 0 +13 T 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 T 14 16 0 15 0 0 +16 T 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 T 24 26 0 25 0 26 +26 T 25 27 39 26 25 27 +27 G 26 28 38 27 26 28 +28 C 27 29 37 28 27 29 +29 T 28 30 36 29 28 0 +30 T 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 C 34 36 0 35 0 0 +36 A 35 37 29 36 0 37 +37 G 36 38 28 37 36 38 +38 C 37 39 27 38 37 39 +39 A 38 40 26 39 38 0 +40 T 39 0 0 40 0 0 +40 dG = -2.295 candidate_22128391 pos=16:66105689-66105729 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 9 +9 C 8 10 26 9 8 10 +10 A 9 11 25 10 9 11 +11 G 10 12 24 11 10 12 +12 A 11 13 23 12 11 13 +13 A 12 14 22 13 12 0 +14 A 13 15 0 14 0 0 +15 G 14 16 0 15 0 0 +16 G 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 G 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 T 21 23 13 22 0 23 +23 T 22 24 12 23 22 24 +24 C 23 25 11 24 23 25 +25 T 24 26 10 25 24 26 +26 G 25 27 9 26 25 27 +27 G 26 28 0 27 26 0 +28 A 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -1.859 candidate_22129434 pos=16:12190394-12190434 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 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11 13 0 12 0 0 +13 G 12 14 0 13 0 0 +14 T 13 15 0 14 0 0 +15 G 14 16 0 15 0 0 +16 T 15 17 10 16 0 17 +17 G 16 18 9 17 16 18 +18 A 17 19 0 18 17 0 +19 C 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 G 21 23 0 22 0 0 +23 T 22 24 37 23 0 24 +24 G 23 25 36 24 23 25 +25 T 24 26 35 25 24 26 +26 C 25 27 34 26 25 0 +27 G 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 T 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 G 33 35 26 34 0 35 +35 A 34 36 25 35 34 36 +36 C 35 37 24 36 35 37 +37 A 36 38 23 37 36 38 +38 A 37 39 0 38 37 0 +39 A 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -2.625 candidate_22133710 pos=16:87137068-87137108 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 C 8 10 0 9 0 0 +10 A 9 11 0 10 0 11 +11 G 10 12 30 11 10 12 +12 C 11 13 29 12 11 13 +13 A 12 14 28 13 12 14 +14 G 13 15 27 14 13 15 +15 T 14 16 26 15 14 0 +16 A 15 17 0 16 0 0 +17 T 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 G 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 T 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 G 25 27 15 26 0 27 +27 C 26 28 14 27 26 28 +28 T 27 29 13 28 27 29 +29 G 28 30 12 29 28 30 +30 C 29 31 11 30 29 31 +31 A 30 32 0 31 30 0 +32 T 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 C 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -2.202 candidate_22133726 pos=16:96130849-96130889 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 C 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 G 10 12 0 11 0 0 +12 C 11 13 0 12 0 0 +13 A 12 14 0 13 0 14 +14 G 13 15 24 14 13 15 +15 T 14 16 23 15 14 16 +16 G 15 17 22 16 15 17 +17 G 16 18 21 17 16 0 +18 C 17 19 0 18 0 0 +19 T 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 C 20 22 17 21 0 22 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candidate_22137318 pos=16:66107612-66107652 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 3 +3 A 2 4 24 3 2 4 +4 A 3 5 23 4 3 5 +5 C 4 6 22 5 4 0 +6 A 5 7 0 6 0 0 +7 A 6 8 20 7 0 8 +8 A 7 9 19 8 7 9 +9 C 8 10 18 9 8 0 +10 A 9 11 0 10 0 0 +11 G 10 12 0 11 0 0 +12 G 11 13 0 12 0 0 +13 G 12 14 0 13 0 0 +14 T 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 G 17 19 9 18 0 19 +19 T 18 20 8 19 18 20 +20 T 19 21 7 20 19 0 +21 G 20 22 0 21 0 0 +22 G 21 23 5 22 0 23 +23 T 22 24 4 23 22 24 +24 T 23 25 3 24 23 0 +25 C 24 26 0 25 0 26 +26 A 25 27 37 26 25 27 +27 A 26 28 36 27 26 28 +28 C 27 29 35 28 27 29 +29 A 28 30 34 29 28 0 +30 C 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 T 33 35 29 34 0 35 +35 G 34 36 28 35 34 36 +36 T 35 37 27 36 35 37 +37 T 36 38 26 37 36 38 +38 T 37 39 0 38 37 0 +39 T 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -2.501 candidate_22138543 pos=16:10153026-10153066 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 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10 +10 A 9 11 18 10 9 11 +11 G 10 12 17 11 10 12 +12 T 11 13 16 12 11 0 +13 G 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 A 15 17 12 16 0 17 +17 C 16 18 11 17 16 18 +18 T 17 19 10 18 17 19 +19 T 18 20 0 19 18 0 +20 G 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 G 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 T 24 26 0 25 0 26 +26 C 25 27 39 26 25 27 +27 T 26 28 38 27 26 0 +28 A 27 29 0 28 0 0 +29 T 28 30 36 29 0 30 +30 G 29 31 35 30 29 0 +31 C 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 C 34 36 30 35 0 36 +36 A 35 37 29 36 35 0 +37 G 36 38 0 37 0 0 +38 A 37 39 27 38 0 39 +39 G 38 40 26 39 38 40 +40 A 39 0 0 40 39 0 +40 dG = -4.005 candidate_22139245 pos=16:30109118-30109158 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 4 +4 A 3 5 14 4 3 5 +5 C 4 6 13 5 4 6 +6 A 5 7 12 6 5 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 C 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 G 10 12 0 11 0 0 +12 T 11 13 6 12 0 13 +13 G 12 14 5 13 12 14 +14 T 13 15 4 14 13 15 +15 G 14 16 0 15 14 0 +16 C 15 17 0 16 0 0 +17 T 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 T 18 20 0 19 0 0 +20 G 19 21 0 20 0 21 +21 C 20 22 40 21 20 22 +22 A 21 23 39 22 21 23 +23 A 22 24 38 23 22 24 +24 G 23 25 37 24 23 0 +25 G 24 26 0 25 0 0 +26 A 25 27 35 26 0 27 +27 T 26 28 34 27 26 28 +28 G 27 29 33 28 27 0 +29 C 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 G 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 C 32 34 28 33 0 34 +34 A 33 35 27 34 33 35 +35 T 34 36 26 35 34 0 +36 A 35 37 0 36 0 0 +37 C 36 38 24 37 0 38 +38 T 37 39 23 38 37 39 +39 T 38 40 22 39 38 40 +40 G 39 0 21 40 39 0 +40 dG = -1.553 candidate_22140417 pos=16:42198376-42198416 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 C 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 T 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 T 16 18 0 17 0 18 +18 G 17 19 37 18 17 19 +19 C 18 20 36 19 18 20 +20 A 19 21 35 20 19 21 +21 A 20 22 34 21 20 0 +22 T 21 23 30 22 0 23 +23 G 22 24 29 23 22 24 +24 G 23 25 28 24 23 0 +25 A 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 T 26 28 0 27 0 0 +28 C 27 29 24 28 0 29 +29 C 28 30 23 29 28 30 +30 A 29 31 22 30 29 0 +31 G 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 T 33 35 21 34 0 35 +35 T 34 36 20 35 34 36 +36 G 35 37 19 36 35 37 +37 C 36 38 18 37 36 38 +38 T 37 39 0 38 37 0 +39 T 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -1.459 candidate_22142541 pos=16:83147797-83147837 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 C 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 T 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 T 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 T 14 16 0 15 0 0 +16 A 15 17 0 16 0 17 +17 G 16 18 36 17 16 18 +18 G 17 19 35 18 17 19 +19 C 18 20 34 19 18 0 +20 A 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 G 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 G 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 G 33 35 19 34 0 35 +35 C 34 36 18 35 34 36 +36 C 35 37 17 36 35 37 +37 A 36 38 0 37 36 0 +38 C 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -1.169 candidate_22143830 pos=16:74196682-74196722 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 C 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 T 10 12 0 11 0 0 +12 C 11 13 0 12 0 0 +13 C 12 14 0 13 0 0 +14 C 13 15 0 14 0 15 +15 C 14 16 25 15 14 16 +16 A 15 17 24 16 15 17 +17 A 16 18 23 17 16 0 +18 A 17 19 0 18 0 0 +19 G 18 20 0 19 0 0 +20 G 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 T 22 24 17 23 0 24 +24 T 23 25 16 24 23 25 +25 G 24 26 15 25 24 26 +26 A 25 27 0 26 25 0 +27 T 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 T 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -1.422 candidate_22143879 pos=16:68111670-68111710 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 7 +7 A 6 8 18 7 6 8 +8 A 7 9 17 8 7 9 +9 C 8 10 16 9 8 10 +10 A 9 11 15 10 9 0 +11 T 10 12 0 11 0 0 +12 C 11 13 0 12 0 0 +13 C 12 14 0 13 0 0 +14 G 13 15 0 14 0 0 +15 T 14 16 10 15 0 16 +16 G 15 17 9 16 15 17 +17 T 16 18 8 17 16 18 +18 T 17 19 7 18 17 19 +19 G 18 20 0 19 18 0 +20 A 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 G 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 C 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 T 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -0.829 candidate_22144385 pos=16:46108727-46108767 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 C 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 T 10 12 0 11 0 12 +12 C 11 13 21 12 11 13 +13 T 12 14 20 13 12 14 +14 G 13 15 19 14 13 0 +15 T 14 16 0 15 0 0 +16 G 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 C 18 20 14 19 0 20 +20 A 19 21 13 20 19 21 +21 G 20 22 12 21 20 22 +22 G 21 23 0 22 21 0 +23 G 22 24 0 23 0 0 +24 G 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 T 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 T 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 G 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 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9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 C 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 T 15 17 0 16 0 17 +17 C 16 18 36 17 16 18 +18 G 17 19 35 18 17 19 +19 T 18 20 34 19 18 0 +20 A 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 T 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 G 24 26 0 25 0 0 +26 G 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 A 33 35 19 34 0 35 +35 C 34 36 18 35 34 36 +36 G 35 37 17 36 35 37 +37 G 36 38 0 37 36 0 +38 C 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -2.893 candidate_22155947 pos=16:44159950-44159990 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 C 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 C 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 T 14 16 0 15 0 0 +16 C 15 17 0 16 0 17 +17 C 16 18 38 17 16 18 +18 T 17 19 37 18 17 19 +19 G 18 20 36 19 18 20 +20 C 19 21 35 20 19 0 +21 T 20 22 0 21 0 0 +22 T 21 23 32 22 0 23 +23 T 22 24 31 23 22 24 +24 C 23 25 30 24 23 25 +25 A 24 26 29 25 24 0 +26 C 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 T 27 29 0 28 0 0 +29 T 28 30 25 29 0 30 +30 G 29 31 24 30 29 31 +31 A 30 32 23 31 30 32 +32 A 31 33 22 32 31 0 +33 G 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 G 34 36 20 35 0 36 +36 C 35 37 19 36 35 37 +37 A 36 38 18 37 36 38 +38 G 37 39 17 38 37 39 +39 A 38 40 0 39 38 0 +40 G 39 0 0 40 0 0 +40 dG = -2.292 candidate_22156764 pos=16:29182366-29182406 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 C 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 C 12 14 0 13 0 0 +14 T 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 T 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 C 24 26 0 25 0 26 +26 A 25 27 37 26 25 27 +27 G 26 28 36 27 26 28 +28 G 27 29 35 28 27 29 +29 G 28 30 34 29 28 0 +30 T 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 C 33 35 29 34 0 35 +35 C 34 36 28 35 34 36 +36 C 35 37 27 36 35 37 +37 T 36 38 26 37 36 38 +38 T 37 39 0 38 37 0 +39 T 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -1.17 candidate_22157299 pos=16:50159646-50159686 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 9 +9 C 8 10 26 9 8 10 +10 C 9 11 25 10 9 11 +11 A 10 12 24 11 10 0 +12 A 11 13 0 12 0 0 +13 G 12 14 0 13 0 0 +14 C 13 15 21 14 0 15 +15 A 14 16 20 15 14 0 +16 T 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 T 19 21 15 20 0 21 +21 G 20 22 14 21 20 0 +22 G 21 23 0 22 0 0 +23 G 22 24 0 23 0 0 +24 T 23 25 11 24 0 25 +25 G 24 26 10 25 24 26 +26 G 25 27 9 26 25 27 +27 G 26 28 0 27 26 0 +28 G 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -1.525 candidate_22158341 pos=16:50123922-50123962 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 9 +9 C 8 10 31 9 8 10 +10 C 9 11 30 10 9 11 +11 A 10 12 29 11 10 12 +12 A 11 13 28 12 11 13 +13 T 12 14 27 13 12 0 +14 T 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 G 19 21 0 20 0 0 +21 G 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 G 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 T 25 27 0 26 0 0 +27 A 26 28 13 27 0 28 +28 T 27 29 12 28 27 29 +29 T 28 30 11 29 28 30 +30 G 29 31 10 30 29 31 +31 G 30 32 9 31 30 32 +32 C 31 33 0 32 31 0 +33 T 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 G 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = 0.494 candidate_22159085 pos=16:27143471-27143511 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 9 +9 C 8 10 29 9 8 10 +10 C 9 11 28 10 9 0 +11 A 10 12 0 11 0 0 +12 C 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 G 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 G 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 G 27 29 10 28 0 29 +29 G 28 30 9 29 28 30 +30 A 29 31 0 30 29 0 +31 T 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = 0.854 candidate_22160134 pos=16:88124329-88124369 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 C 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 12 +12 C 11 13 24 12 11 13 +13 T 12 14 23 13 12 0 +14 C 13 15 0 14 0 0 +15 T 14 16 0 15 0 0 +16 C 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 A 22 24 13 23 0 24 +24 G 23 25 12 24 23 25 +25 A 24 26 0 25 24 0 +26 A 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -2.399 candidate_22161492 pos=16:90147842-90147882 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 4 +4 A 3 5 39 4 3 5 +5 C 4 6 38 5 4 6 +6 A 5 7 37 6 5 7 +7 A 6 8 36 7 6 8 +8 A 7 9 35 8 7 0 +9 C 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 32 11 0 12 +12 G 11 13 31 12 11 13 +13 C 12 14 30 13 12 0 +14 A 13 15 0 14 0 0 +15 G 14 16 0 15 0 0 +16 G 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 G 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 T 25 27 0 26 0 0 +27 T 26 28 0 27 0 0 +28 T 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 G 29 31 13 30 0 31 +31 C 30 32 12 31 30 32 +32 T 31 33 11 32 31 0 +33 A 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 T 34 36 8 35 0 36 +36 T 35 37 7 36 35 37 +37 T 36 38 6 37 36 38 +38 G 37 39 5 38 37 39 +39 T 38 40 4 39 38 40 +40 G 39 0 0 40 39 0 +40 dG = -2.042 candidate_22162118 pos=16:44151172-44151212 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 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0 21 0 0 +22 G 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 T 23 25 19 24 0 25 +25 G 24 26 18 25 24 26 +26 A 25 27 0 26 25 0 +27 A 26 28 0 27 0 28 +28 C 27 29 36 28 27 29 +29 C 28 30 35 29 28 0 +30 A 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 G 34 36 29 35 0 36 +36 G 35 37 28 36 35 37 +37 G 36 38 0 37 36 0 +38 G 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -2.145 candidate_22165988 pos=16:63157019-63157059 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 C 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 T 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 G 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 T 23 25 0 24 0 25 +25 A 24 26 38 25 24 26 +26 A 25 27 37 26 25 27 +27 A 26 28 36 27 26 28 +28 T 27 29 35 28 27 29 +29 G 28 30 34 29 28 0 +30 G 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 C 33 35 29 34 0 35 +35 A 34 36 28 35 34 36 +36 T 35 37 27 36 35 37 +37 T 36 38 26 37 36 38 +38 T 37 39 25 38 37 39 +39 C 38 40 0 39 38 0 +40 T 39 0 0 40 0 0 +40 dG = -1.358 candidate_22167297 pos=16:88195353-88195393 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 C 8 10 0 9 0 10 +10 C 9 11 20 10 9 11 +11 C 10 12 19 11 10 12 +12 A 11 13 18 12 11 0 +13 G 12 14 0 13 0 0 +14 T 13 15 0 14 0 0 +15 G 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 T 16 18 0 17 0 0 +18 T 17 19 12 18 0 19 +19 G 18 20 11 19 18 20 +20 G 19 21 10 20 19 21 +21 C 20 22 0 21 20 0 +22 A 21 23 0 22 0 0 +23 T 22 24 0 23 0 0 +24 G 23 25 0 24 0 0 +25 G 24 26 0 25 0 0 +26 C 25 27 0 26 0 0 +27 T 26 28 0 27 0 0 +28 C 27 29 0 28 0 29 +29 G 28 30 39 29 28 30 +30 A 29 31 38 30 29 31 +31 A 30 32 37 31 30 0 +32 A 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 T 36 38 31 37 0 38 +38 T 37 39 30 38 37 39 +39 C 38 40 29 39 38 40 +40 T 39 0 0 40 39 0 +40 dG = -2.031 candidate_22167603 pos=16:49183383-49183423 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 C 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 T 12 14 0 13 0 0 +14 G 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 T 15 17 0 16 0 0 +17 C 16 18 0 17 0 18 +18 C 17 19 30 18 17 19 +19 A 18 20 29 19 18 20 +20 G 19 21 28 20 19 21 +21 A 20 22 27 21 20 0 +22 C 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 G 23 25 0 24 0 0 +25 G 24 26 0 25 0 0 +26 C 25 27 0 26 0 0 +27 T 26 28 21 27 0 28 +28 C 27 29 20 28 27 29 +29 T 28 30 19 29 28 30 +30 G 29 31 18 30 29 0 +31 T 30 32 0 31 0 32 +32 G 31 33 39 32 31 33 +33 C 32 34 38 33 32 0 +34 A 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 G 37 39 33 38 0 39 +39 C 38 40 32 39 38 40 +40 A 39 0 0 40 39 0 +40 dG = 0.004 candidate_22168403 pos=16:92162192-92162232 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 C 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 C 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 G 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 T 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 G 20 22 0 21 0 22 +22 C 21 23 29 22 21 23 +23 C 22 24 28 23 22 0 +24 C 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 T 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 G 27 29 23 28 0 29 +29 G 28 30 22 29 28 30 +30 T 29 31 0 30 29 0 +31 C 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 C 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -0.486 candidate_22168417 pos=16:57136534-57136574 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 C 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 C 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 G 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 C 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 G 18 20 0 19 0 0 +20 T 19 21 0 20 0 21 +21 A 20 22 28 21 20 22 +22 C 21 23 27 22 21 0 +23 A 22 24 0 23 0 0 +24 G 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 G 26 28 22 27 0 28 +28 T 27 29 21 28 27 29 +29 G 28 30 0 29 28 0 +30 A 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -0.892 candidate_22168459 pos=16:74173913-74173953 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 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0 17 0 0 +18 G 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 C 19 21 14 20 0 21 +21 C 20 22 13 21 20 22 +22 C 21 23 12 22 21 23 +23 T 22 24 0 23 22 0 +24 T 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 G 25 27 0 26 0 0 +27 T 26 28 0 27 0 0 +28 T 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -2.341 candidate_22169694 pos=16:16192234-16192274 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 9 +9 C 8 10 40 9 8 10 +10 C 9 11 39 10 9 0 +11 C 10 12 0 11 0 0 +12 G 11 13 37 12 0 13 +13 G 12 14 36 13 12 0 +14 T 13 15 0 14 0 0 +15 A 14 16 34 15 0 16 +16 T 15 17 33 16 15 17 +17 G 16 18 32 17 16 18 +18 C 17 19 31 18 17 0 +19 C 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 T 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 G 24 26 0 25 0 0 +26 T 25 27 0 26 0 0 +27 T 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 G 30 32 18 31 0 32 +32 C 31 33 17 32 31 33 +33 A 32 34 16 33 32 34 +34 T 33 35 15 34 33 0 +35 T 34 36 0 35 0 0 +36 C 35 37 13 36 0 37 +37 C 36 38 12 37 36 0 +38 T 37 39 0 38 0 0 +39 G 38 40 10 39 0 40 +40 G 39 0 9 40 39 0 +40 dG = -1.839 candidate_22169998 pos=16:9169681-9169721 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 9 +9 C 8 10 23 9 8 10 +10 C 9 11 22 10 9 11 +11 C 10 12 21 11 10 0 +12 T 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 T 15 17 0 16 0 0 +17 T 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 G 20 22 11 21 0 22 +22 G 21 23 10 22 21 23 +23 G 22 24 9 23 22 24 +24 A 23 25 0 24 23 0 +25 G 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 T 26 28 0 27 0 0 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0 0 +9 C 8 10 0 9 0 0 +10 T 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 A 11 13 0 12 0 13 +13 C 12 14 19 13 12 0 +14 T 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 T 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 G 18 20 13 19 0 20 +20 A 19 21 0 20 19 0 +21 A 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 T 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 G 24 26 0 25 0 0 +26 C 25 27 0 26 0 0 +27 C 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -2.355 candidate_22193752 pos=16:43152789-43152829 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 5 +5 C 4 6 23 5 4 6 +6 A 5 7 22 6 5 7 +7 A 6 8 21 7 6 8 +8 A 7 9 20 8 7 9 +9 C 8 10 19 9 8 0 +10 T 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 G 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 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5 20 19 21 +21 T 20 22 4 21 20 0 +22 G 21 23 39 22 0 23 +23 A 22 24 38 23 22 24 +24 G 23 25 37 24 23 25 +25 C 24 26 36 25 24 0 +26 A 25 27 0 26 0 0 +27 T 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 G 35 37 25 36 0 37 +37 C 36 38 24 37 36 38 +38 T 37 39 23 38 37 39 +39 C 38 40 22 39 38 40 +40 A 39 0 0 40 39 0 +40 dG = -0.439 candidate_22195602 pos=16:64101875-64101915 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 C 8 10 0 9 0 0 +10 T 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 C 11 13 0 12 0 0 +13 T 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 T 14 16 0 15 0 0 +16 G 15 17 0 16 0 0 +17 T 16 18 0 17 0 0 +18 C 17 19 0 18 0 19 +19 C 18 20 30 19 18 20 +20 C 19 21 29 20 19 21 +21 A 20 22 28 21 20 0 +22 G 21 23 0 22 0 0 +23 G 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 T 27 29 21 28 0 29 +29 G 28 30 20 29 28 30 +30 G 29 31 19 30 29 31 +31 T 30 32 0 31 30 0 +32 T 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -3.537 candidate_22196342 pos=16:18179921-18179961 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 C 8 10 0 9 0 0 +10 T 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 T 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 T 13 15 0 14 0 0 +15 G 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 T 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 T 18 20 0 19 0 20 +20 G 19 21 35 20 19 21 +21 C 20 22 34 21 20 22 +22 C 21 23 33 22 21 0 +23 T 22 24 0 23 0 0 +24 G 23 25 31 24 0 25 +25 G 24 26 30 25 24 0 +26 T 25 27 0 26 0 0 +27 T 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 C 29 31 25 30 0 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G 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 T 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 T 15 17 7 16 0 17 +17 T 16 18 6 17 16 18 +18 G 17 19 5 18 17 19 +19 T 18 20 4 19 18 20 +20 C 19 21 0 20 19 0 +21 C 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 A 23 25 0 24 0 25 +25 C 24 26 33 25 24 26 +26 A 25 27 32 26 25 0 +27 G 26 28 0 27 0 0 +28 T 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 T 31 33 26 32 0 33 +33 G 32 34 25 33 32 34 +34 A 33 35 0 34 33 0 +35 T 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = 0.584 candidate_22200544 pos=16:97127845-97127885 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 5 +5 C 4 6 14 5 4 6 +6 A 5 7 13 6 5 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 C 8 10 0 9 0 0 +10 T 9 11 0 10 0 0 +11 G 10 12 0 11 0 0 +12 C 11 13 0 12 0 0 +13 T 12 14 6 13 0 14 +14 G 13 15 5 14 13 15 +15 A 14 16 0 15 14 0 +16 A 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 C 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -2.89 candidate_22200957 pos=16:31174384-31174424 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 8 +8 A 7 9 21 8 7 9 +9 C 8 10 20 9 8 10 +10 T 9 11 19 10 9 11 +11 G 10 12 18 11 10 0 +12 G 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 G 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 C 17 19 11 18 0 19 +19 A 18 20 10 19 18 20 +20 G 19 21 9 20 19 21 +21 T 20 22 8 21 20 22 +22 G 21 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pos=16:57181778-57181818 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 3 +3 A 2 4 18 3 2 4 +4 A 3 5 17 4 3 5 +5 C 4 6 16 5 4 6 +6 A 5 7 15 6 5 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 C 8 10 0 9 0 0 +10 T 9 11 0 10 0 0 +11 T 10 12 0 11 0 0 +12 C 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 T 14 16 6 15 0 16 +16 G 15 17 5 16 15 17 +17 T 16 18 4 17 16 18 +18 T 17 19 3 18 17 19 +19 C 18 20 0 19 18 0 +20 A 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 C 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -0.516 candidate_22206827 pos=16:20161423-20161463 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 5 +5 C 4 6 12 5 4 6 +6 A 5 7 11 6 5 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 C 8 10 0 9 0 0 +10 T 9 11 0 10 0 0 +11 T 10 12 6 11 0 12 +12 G 11 13 5 12 11 13 +13 A 12 14 0 13 12 0 +14 A 13 15 0 14 0 0 +15 G 14 16 0 15 0 0 +16 G 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 G 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 G 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -5.442 candidate_22207174 pos=16:81171525-81171565 +1 A 0 2 0 1 0 2 +2 A 1 3 32 2 1 3 +3 A 2 4 31 3 2 4 +4 A 3 5 30 4 3 5 +5 C 4 6 29 5 4 6 +6 A 5 7 28 6 5 7 +7 A 6 8 27 7 6 8 +8 A 7 9 26 8 7 9 +9 C 8 10 25 9 8 0 +10 T 9 11 0 10 0 0 +11 T 10 12 0 11 0 0 +12 G 11 13 24 12 0 13 +13 C 12 14 23 13 12 14 +14 A 13 15 22 14 13 15 +15 A 14 16 21 15 14 0 +16 A 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 T 20 22 15 21 0 22 +22 T 21 23 14 22 21 23 +23 G 22 24 13 23 22 24 +24 T 23 25 12 24 23 0 +25 G 24 26 9 25 0 26 +26 T 25 27 8 26 25 27 +27 T 26 28 7 27 26 28 +28 T 27 29 6 28 27 29 +29 G 28 30 5 29 28 30 +30 T 29 31 4 30 29 31 +31 T 30 32 3 31 30 32 +32 T 31 33 2 32 31 33 +33 G 32 34 0 33 32 0 +34 T 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -3.755 candidate_22207831 pos=16:40187696-40187736 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 4 +4 A 3 5 13 4 3 5 +5 C 4 6 12 5 4 6 +6 A 5 7 11 6 5 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 C 8 10 0 9 0 0 +10 T 9 11 0 10 0 0 +11 T 10 12 6 11 0 12 +12 G 11 13 5 12 11 13 +13 T 12 14 4 13 12 14 +14 C 13 15 0 14 13 0 +15 A 14 16 0 15 0 0 +16 C 15 17 0 16 0 0 +17 T 16 18 0 17 0 18 +18 A 17 19 40 18 17 19 +19 G 18 20 39 19 18 20 +20 T 19 21 38 20 19 21 +21 C 20 22 37 21 20 0 +22 C 21 23 0 22 0 0 +23 A 22 24 34 23 0 24 +24 G 23 25 33 24 23 25 +25 T 24 26 32 25 24 26 +26 C 25 27 31 26 25 0 +27 C 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 G 30 32 26 31 0 32 +32 A 31 33 25 32 31 33 +33 C 32 34 24 33 32 34 +34 T 33 35 23 34 33 0 +35 C 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 G 36 38 21 37 0 38 +38 A 37 39 20 38 37 39 +39 C 38 40 19 39 38 40 +40 T 39 0 18 40 39 0 +40 dG = -1.925 candidate_22208932 pos=16:62193639-62193679 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 C 8 10 0 9 0 0 +10 T 9 11 0 10 0 0 +11 T 10 12 0 11 0 0 +12 T 11 13 0 12 0 0 +13 C 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 G 14 16 0 15 0 0 +16 A 15 17 0 16 0 17 +17 A 16 18 33 17 16 18 +18 G 17 19 32 18 17 19 +19 G 18 20 31 19 18 20 +20 A 19 21 30 20 19 21 +21 A 20 22 29 21 20 0 +22 G 21 23 0 22 0 0 +23 G 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 T 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 T 28 30 21 29 0 30 +30 T 29 31 20 30 29 31 +31 C 30 32 19 31 30 32 +32 C 31 33 18 32 31 33 +33 T 32 34 17 33 32 34 +34 A 33 35 0 34 33 0 +35 C 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -1.205 candidate_22213516 pos=16:42184208-42184248 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 8 +8 A 7 9 26 8 7 9 +9 G 8 10 25 9 8 10 +10 A 9 11 24 10 9 11 +11 A 10 12 23 11 10 12 +12 A 11 13 22 12 11 0 +13 A 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 T 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 G 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 G 20 22 0 21 0 0 +22 T 21 23 12 22 0 23 +23 T 22 24 11 23 22 24 +24 T 23 25 10 24 23 25 +25 C 24 26 9 25 24 26 +26 T 25 27 8 26 25 27 +27 G 26 28 0 27 26 0 +28 T 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -5.901 candidate_22214148 pos=16:32110929-32110969 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 G 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 14 +14 G 13 15 22 14 13 15 +15 C 14 16 21 15 14 16 +16 A 15 17 20 16 15 0 +17 G 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 T 19 21 16 20 0 21 +21 G 20 22 15 21 20 22 +22 C 21 23 14 22 21 23 +23 A 22 24 0 23 22 0 +24 G 23 25 0 24 0 25 +25 G 24 26 37 25 24 26 +26 C 25 27 36 26 25 27 +27 C 26 28 35 27 26 28 +28 A 27 29 34 28 27 0 +29 A 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 T 33 35 28 34 0 35 +35 G 34 36 27 35 34 36 +36 G 35 37 26 36 35 37 +37 C 36 38 25 37 36 38 +38 A 37 39 0 38 37 0 +39 C 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -2.705 candidate_22214644 pos=16:10161150-10161190 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 4 +4 A 3 5 27 4 3 5 +5 C 4 6 26 5 4 6 +6 A 5 7 25 6 5 0 +7 A 6 8 0 7 0 0 +8 A 7 9 23 8 0 9 +9 G 8 10 22 9 8 10 +10 A 9 11 21 10 9 11 +11 A 10 12 20 11 10 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 T 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 T 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 T 19 21 11 20 0 21 +21 T 20 22 10 21 20 22 +22 C 21 23 9 22 21 23 +23 T 22 24 8 23 22 0 +24 G 23 25 0 24 0 0 +25 T 24 26 6 25 0 26 +26 G 25 27 5 26 25 27 +27 T 26 28 4 27 26 28 +28 C 27 29 0 28 27 0 +29 C 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 T 30 32 0 31 0 32 +32 G 31 33 40 32 31 33 +33 C 32 34 39 33 32 34 +34 C 33 35 38 34 33 0 +35 A 34 36 0 35 0 0 +36 G 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 G 37 39 34 38 0 39 +39 G 38 40 33 39 38 40 +40 C 39 0 32 40 39 0 +40 dG = -3.188 candidate_22218001 pos=16:6153321-6153361 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 5 +5 C 4 6 23 5 4 6 +6 A 5 7 22 6 5 7 +7 A 6 8 21 7 6 8 +8 A 7 9 20 8 7 9 +9 G 8 10 19 9 8 10 +10 A 9 11 18 10 9 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 C 12 14 0 13 0 0 +14 T 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 C 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 T 17 19 10 18 0 19 +19 C 18 20 9 19 18 20 +20 T 19 21 8 20 19 21 +21 T 20 22 7 21 20 22 +22 T 21 23 6 22 21 23 +23 G 22 24 5 23 22 24 +24 G 23 25 0 24 23 0 +25 G 24 26 0 25 0 0 +26 T 25 27 0 26 0 0 +27 C 26 28 0 27 0 0 +28 T 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = 0.164 candidate_22220205 pos=16:51104997-51105037 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 G 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 G 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 G 17 19 0 18 0 0 +19 G 18 20 0 19 0 20 +20 A 19 21 28 20 19 21 +21 G 20 22 27 21 20 0 +22 A 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 G 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 C 26 28 21 27 0 28 +28 T 27 29 20 28 27 29 +29 G 28 30 0 29 28 0 +30 T 29 31 0 30 0 0 +31 G 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = 0.498 candidate_22221967 pos=16:78121594-78121634 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 7 +7 A 6 8 32 7 6 8 +8 A 7 9 31 8 7 9 +9 G 8 10 30 9 8 10 +10 A 9 11 29 10 9 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 T 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 G 18 20 0 19 0 0 +20 G 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 C 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 T 28 30 10 29 0 30 +30 C 29 31 9 30 29 31 +31 T 30 32 8 31 30 32 +32 T 31 33 7 32 31 33 +33 C 32 34 0 33 32 0 +34 C 33 35 0 34 0 0 +35 C 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = 0.274 candidate_22226467 pos=16:85140359-85140399 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 G 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 G 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 A 13 15 0 14 0 15 +15 G 14 16 28 15 14 16 +16 G 15 17 27 16 15 0 +17 A 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 G 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 G 22 24 0 23 0 0 +24 G 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 C 26 28 16 27 0 28 +28 C 27 29 15 28 27 29 +29 A 28 30 0 29 28 0 +30 G 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -0.919 candidate_22230471 pos=16:48150618-48150658 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 G 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 T 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 T 13 15 0 14 0 0 +15 T 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 A 19 21 0 20 0 21 +21 G 20 22 30 21 20 22 +22 G 21 23 29 22 21 23 +23 A 22 24 28 23 22 0 +24 C 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 C 26 28 0 27 0 0 +28 T 27 29 23 28 0 29 +29 C 28 30 22 29 28 30 +30 C 29 31 21 30 29 31 +31 A 30 32 0 31 30 0 +32 C 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 G 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -2.827 candidate_22231264 pos=16:35100492-35100532 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 G 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 A 10 12 0 11 0 12 +12 T 11 13 23 12 11 13 +13 G 12 14 22 13 12 14 +14 A 13 15 21 14 13 15 +15 A 14 16 20 15 14 0 +16 T 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 T 19 21 15 20 0 21 +21 T 20 22 14 21 20 22 +22 C 21 23 13 22 21 23 +23 A 22 24 12 23 22 0 +24 G 23 25 0 24 0 0 +25 G 24 26 0 25 0 0 +26 C 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 T 27 29 0 28 0 29 +29 G 28 30 39 29 28 30 +30 G 29 31 38 30 29 31 +31 T 30 32 37 31 30 32 +32 G 31 33 36 32 31 0 +33 A 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 C 35 37 32 36 0 37 +37 A 36 38 31 37 36 38 +38 C 37 39 30 38 37 39 +39 C 38 40 29 39 38 40 +40 C 39 0 0 40 39 0 +40 dG = -2.764 candidate_22231544 pos=16:62146595-62146635 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 G 8 10 0 9 0 0 +10 A 9 11 0 10 0 11 +11 A 10 12 22 11 10 12 +12 T 11 13 21 12 11 13 +13 G 12 14 20 13 12 14 +14 G 13 15 19 14 13 0 +15 A 14 16 0 15 0 0 +16 C 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 G 17 19 0 18 0 0 +19 C 18 20 14 19 0 20 +20 C 19 21 13 20 19 21 +21 A 20 22 12 21 20 22 +22 T 21 23 11 22 21 0 +23 G 22 24 0 23 0 24 +24 C 23 25 35 24 23 25 +25 C 24 26 34 25 24 26 +26 A 25 27 33 26 25 0 +27 C 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 T 32 34 26 33 0 34 +34 G 33 35 25 34 33 35 +35 G 34 36 24 35 34 36 +36 A 35 37 0 36 35 0 +37 A 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -3.302 candidate_22234415 pos=16:53153978-53154018 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 G 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 14 +14 C 13 15 26 14 13 15 +15 C 14 16 25 15 14 16 +16 A 15 17 24 16 15 17 +17 C 16 18 23 17 16 0 +18 T 17 19 0 18 0 0 +19 G 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 G 22 24 17 23 0 24 +24 T 23 25 16 24 23 25 +25 G 24 26 15 25 24 26 +26 G 25 27 14 26 25 27 +27 G 26 28 0 27 26 0 +28 C 27 29 0 28 0 0 +29 T 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -1.767 candidate_22235188 pos=16:84110136-84110176 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 G 8 10 0 9 0 10 +10 A 9 11 29 10 9 11 +11 C 10 12 28 11 10 0 +12 A 11 13 0 12 0 0 +13 C 12 14 26 13 0 14 +14 A 13 15 25 14 13 15 +15 G 14 16 24 15 14 0 +16 A 15 17 0 16 0 0 +17 T 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 C 23 25 15 24 0 25 +25 T 24 26 14 25 24 26 +26 G 25 27 13 26 25 0 +27 G 26 28 0 27 0 0 +28 G 27 29 11 28 0 29 +29 T 28 30 10 29 28 30 +30 A 29 31 0 30 29 0 +31 T 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 G 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -1.452 candidate_22235294 pos=16:85110795-85110835 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 G 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 A 11 13 0 12 0 13 +13 C 12 14 28 13 12 14 +14 A 13 15 27 14 13 15 +15 T 14 16 26 15 14 16 +16 G 15 17 25 16 15 0 +17 C 16 18 0 17 0 0 +18 G 17 19 0 18 0 0 +19 T 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 C 24 26 16 25 0 26 +26 A 25 27 15 26 25 27 +27 T 26 28 14 27 26 28 +28 G 27 29 13 28 27 29 +29 G 28 30 0 29 28 0 +30 C 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -1.822 candidate_22235562 pos=16:66120355-66120395 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 G 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 C 12 14 0 13 0 0 +14 T 13 15 0 14 0 15 +15 G 14 16 36 15 14 16 +16 A 15 17 35 16 15 17 +17 G 16 18 34 17 16 18 +18 C 17 19 33 18 17 0 +19 T 18 20 0 19 0 0 +20 G 19 21 0 20 0 0 +21 G 20 22 0 21 0 0 +22 G 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 G 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 G 32 34 18 33 0 34 +34 C 33 35 17 34 33 35 +35 T 34 36 16 35 34 36 +36 C 35 37 15 36 35 37 +37 T 36 38 0 37 36 0 +38 C 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -0.312 candidate_22237073 pos=16:95114060-95114100 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 5 +5 C 4 6 24 5 4 6 +6 A 5 7 23 6 5 7 +7 A 6 8 22 7 6 8 +8 A 7 9 21 8 7 0 +9 G 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 T 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 T 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 T 20 22 8 21 0 22 +22 T 21 23 7 22 21 23 +23 T 22 24 6 23 22 24 +24 G 23 25 5 24 23 25 +25 C 24 26 0 25 24 0 +26 A 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -1.642 candidate_22238881 pos=16:91149318-91149358 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 G 8 10 0 9 0 10 +10 A 9 11 37 10 9 11 +11 C 10 12 36 11 10 12 +12 C 11 13 35 12 11 13 +13 C 12 14 34 13 12 0 +14 A 13 15 0 14 0 0 +15 G 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 G 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 G 24 26 0 25 0 0 +26 T 25 27 0 26 0 0 +27 C 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 T 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 G 33 35 13 34 0 35 +35 G 34 36 12 35 34 36 +36 G 35 37 11 36 35 37 +37 T 36 38 10 37 36 38 +38 A 37 39 0 38 37 0 +39 T 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -0.95 candidate_22240123 pos=16:58145273-58145313 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 G 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 T 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 A 20 22 0 21 0 22 +22 G 21 23 40 22 21 23 +23 G 22 24 39 23 22 24 +24 G 23 25 38 24 23 0 +25 C 24 26 0 25 0 0 +26 G 25 27 35 26 0 27 +27 T 26 28 34 27 26 28 +28 T 27 29 33 28 27 0 +29 C 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 A 32 34 28 33 0 34 +34 A 33 35 27 34 33 35 +35 C 34 36 26 35 34 0 +36 T 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 C 37 39 24 38 0 39 +39 C 38 40 23 39 38 40 +40 C 39 0 22 40 39 0 +40 dG = -0.649 candidate_22240135 pos=16:32114579-32114619 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 G 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 T 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 A 13 15 0 14 0 15 +15 C 14 16 32 15 14 16 +16 C 15 17 31 16 15 17 +17 A 16 18 30 17 16 0 +18 T 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 T 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 G 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 T 29 31 17 30 0 31 +31 G 30 32 16 31 30 32 +32 G 31 33 15 32 31 33 +33 A 32 34 0 33 32 0 +34 T 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -3.637 candidate_22240291 pos=16:18162248-18162288 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 7 +7 A 6 8 16 7 6 8 +8 A 7 9 15 8 7 9 +9 G 8 10 14 9 8 0 +10 A 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 T 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 C 13 15 9 14 0 15 +15 T 14 16 8 15 14 16 +16 T 15 17 7 16 15 17 +17 A 16 18 0 17 16 0 +18 C 17 19 0 18 0 0 +19 A 18 20 0 19 0 20 +20 T 19 21 34 20 19 21 +21 C 20 22 33 21 20 22 +22 C 21 23 32 22 21 23 +23 A 22 24 31 23 22 24 +24 G 23 25 30 24 23 0 +25 C 24 26 0 25 0 0 +26 C 25 27 0 26 0 0 +27 C 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 T 28 30 0 29 0 0 +30 C 29 31 24 30 0 31 +31 T 30 32 23 31 30 32 +32 G 31 33 22 32 31 33 +33 G 32 34 21 33 32 34 +34 A 33 35 20 34 33 0 +35 G 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = 0.484 candidate_22242413 pos=16:97176240-97176280 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 5 +5 C 4 6 17 5 4 6 +6 A 5 7 16 6 5 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 G 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 G 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 T 15 17 6 16 0 17 +17 G 16 18 5 17 16 18 +18 A 17 19 0 18 17 0 +19 A 18 20 0 19 0 0 +20 G 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 G 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 G 24 26 0 25 0 0 +26 G 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 G 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -2.593 candidate_22242847 pos=16:41171621-41171661 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 G 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 G 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 T 14 16 0 15 0 0 +16 G 15 17 0 16 0 0 +17 T 16 18 0 17 0 0 +18 T 17 19 0 18 0 19 +19 C 18 20 38 19 18 20 +20 C 19 21 37 20 19 21 +21 T 20 22 36 21 20 22 +22 A 21 23 35 22 21 0 +23 C 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 T 24 26 32 25 0 26 +26 G 25 27 31 26 25 0 +27 G 26 28 0 27 0 0 +28 T 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 C 30 32 26 31 0 32 +32 A 31 33 25 32 31 0 +33 C 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 T 34 36 22 35 0 36 +36 A 35 37 21 36 35 37 +37 G 36 38 20 37 36 38 +38 G 37 39 19 38 37 39 +39 A 38 40 0 39 38 0 +40 C 39 0 0 40 0 0 +40 dG = -1.217 candidate_22243294 pos=16:91118707-91118747 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 G 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 G 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 G 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 G 21 23 0 22 0 23 +23 G 22 24 37 23 22 24 +24 G 23 25 36 24 23 0 +25 A 24 26 0 25 0 0 +26 G 25 27 34 26 0 27 +27 A 26 28 33 27 26 28 +28 C 27 29 32 28 27 0 +29 A 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 G 30 32 0 31 0 0 +32 G 31 33 28 32 0 33 +33 T 32 34 27 33 32 34 +34 C 33 35 26 34 33 0 +35 A 34 36 0 35 0 0 +36 C 35 37 24 36 0 37 +37 C 36 38 23 37 36 38 +38 A 37 39 0 38 37 0 +39 A 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +0 dG = 998.226 candidate_22244228 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27 0 0 +28 T 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 G 29 31 15 30 0 31 +31 C 30 32 14 31 30 32 +32 C 31 33 13 32 31 33 +33 T 32 34 12 33 32 34 +34 G 33 35 0 34 33 0 +35 G 34 36 0 35 0 0 +36 G 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -1.672 candidate_22267986 pos=16:49132159-49132199 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 G 8 10 0 9 0 10 +10 C 9 11 22 10 9 11 +11 A 10 12 21 11 10 12 +12 A 11 13 20 12 11 13 +13 G 12 14 19 13 12 0 +14 T 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 T 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 C 18 20 13 19 0 20 +20 T 19 21 12 20 19 21 +21 T 20 22 11 21 20 22 +22 G 21 23 10 22 21 23 +23 T 22 24 0 23 22 0 +24 C 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 A 31 33 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A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 6 +6 A 5 7 39 6 5 7 +7 A 6 8 38 7 6 8 +8 A 7 9 37 8 7 9 +9 G 8 10 36 9 8 10 +10 C 9 11 35 10 9 11 +11 A 10 12 34 11 10 0 +12 G 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 C 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 T 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 T 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 G 24 26 0 25 0 0 +26 G 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 G 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 T 33 35 11 34 0 35 +35 G 34 36 10 35 34 36 +36 C 35 37 9 36 35 37 +37 T 36 38 8 37 36 38 +38 T 37 39 7 38 37 39 +39 T 38 40 6 39 38 40 +40 T 39 0 0 40 39 0 +40 dG = -2.985 candidate_22272621 pos=16:78164887-78164927 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 9 +9 G 8 10 18 9 8 10 +10 C 9 11 17 10 9 11 +11 A 10 12 16 11 10 0 +12 G 11 13 0 12 0 0 +13 G 12 14 0 13 0 0 +14 G 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 T 15 17 11 16 0 17 +17 G 16 18 10 17 16 18 +18 C 17 19 9 18 17 0 +19 C 18 20 36 19 0 20 +20 T 19 21 35 20 19 21 +21 T 20 22 34 21 20 22 +22 G 21 23 33 22 21 0 +23 G 22 24 0 23 0 0 +24 C 23 25 31 24 0 25 +25 T 24 26 30 25 24 0 +26 A 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 G 29 31 25 30 0 31 +31 G 30 32 24 31 30 0 +32 A 31 33 0 32 0 0 +33 C 32 34 22 33 0 34 +34 A 33 35 21 34 33 35 +35 A 34 36 20 35 34 36 +36 G 35 37 19 36 35 37 +37 T 36 38 0 37 36 0 +38 G 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -2.631 candidate_22274021 pos=16:18122906-18122946 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 9 +9 G 8 10 18 9 8 10 +10 C 9 11 17 10 9 11 +11 A 10 12 16 11 10 0 +12 T 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 T 13 15 0 14 0 0 +15 T 14 16 0 15 0 0 +16 T 15 17 11 16 0 17 +17 G 16 18 10 17 16 18 +18 C 17 19 9 18 17 19 +19 A 18 20 0 19 18 0 +20 C 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 C 22 24 0 23 0 24 +24 C 23 25 36 24 23 25 +25 T 24 26 35 25 24 26 +26 G 25 27 34 26 25 27 +27 T 26 28 33 27 26 0 +28 G 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 G 32 34 27 33 0 34 +34 C 33 35 26 34 33 35 +35 A 34 36 25 35 34 36 +36 G 35 37 24 36 35 37 +37 T 36 38 0 37 36 0 +38 G 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -0.904 candidate_22274554 pos=16:4153705-4153745 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 9 +9 G 8 10 29 9 8 10 +10 C 9 11 28 10 9 0 +11 A 10 12 0 11 0 0 +12 T 11 13 26 12 0 13 +13 G 12 14 25 13 12 0 +14 A 13 15 0 14 0 0 +15 G 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 G 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21 23 10 22 21 23 +23 T 22 24 9 23 22 0 +24 G 23 25 0 24 0 0 +25 T 24 26 6 25 0 26 +26 G 25 27 5 26 25 27 +27 T 26 28 4 27 26 28 +28 G 27 29 0 28 27 0 +29 T 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 G 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -2.694 candidate_22274960 pos=16:18191168-18191208 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 3 +3 A 2 4 15 3 2 4 +4 A 3 5 14 4 3 5 +5 C 4 6 13 5 4 6 +6 A 5 7 12 6 5 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 G 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 T 11 13 6 12 0 13 +13 G 12 14 5 13 12 14 +14 T 13 15 4 14 13 15 +15 T 14 16 3 15 14 16 +16 A 15 17 0 16 15 0 +17 T 16 18 0 17 0 0 +18 G 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 A 30 32 0 31 0 32 +32 G 31 33 40 32 31 33 +33 C 32 34 39 33 32 34 +34 C 33 35 38 34 33 0 +35 C 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 G 37 39 34 38 0 39 +39 G 38 40 33 39 38 40 +40 C 39 0 32 40 39 0 +40 dG = -4.217 candidate_22275089 pos=16:64170152-64170192 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 G 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 T 11 13 0 12 0 0 +13 T 12 14 0 13 0 14 +14 A 13 15 34 14 13 15 +15 G 14 16 33 15 14 16 +16 C 15 17 32 16 15 17 +17 A 16 18 31 17 16 18 +18 A 17 19 30 18 17 20 +19 G 18 20 0 19 0 0 +20 T 19 21 29 20 18 21 +21 G 20 22 28 21 20 22 +22 C 21 23 27 22 21 0 +23 A 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 G 26 28 22 27 0 28 +28 C 27 29 21 28 27 29 +29 A 28 30 20 29 28 30 +30 T 29 31 18 30 29 31 +31 T 30 32 17 31 30 32 +32 G 31 33 16 32 31 33 +33 C 32 34 15 33 32 34 +34 T 33 35 14 34 33 35 +35 A 34 36 0 35 34 0 +36 C 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -1.215 candidate_22276314 pos=16:55137295-55137335 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 4 +4 A 3 5 27 4 3 5 +5 C 4 6 26 5 4 6 +6 A 5 7 25 6 5 7 +7 A 6 8 24 7 6 8 +8 A 7 9 23 8 7 0 +9 G 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 T 14 16 0 15 0 0 +16 C 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 T 22 24 8 23 0 24 +24 T 23 25 7 24 23 25 +25 T 24 26 6 25 24 26 +26 G 25 27 5 26 25 27 +27 T 26 28 4 27 26 28 +28 G 27 29 0 28 27 0 +29 A 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 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candidate_22277296 pos=16:15184133-15184173 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 8 +8 A 7 9 22 8 7 9 +9 G 8 10 21 9 8 10 +10 C 9 11 20 10 9 11 +11 C 10 12 19 11 10 0 +12 A 11 13 0 12 0 0 +13 C 12 14 0 13 0 0 +14 T 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 C 15 17 0 16 0 0 +17 T 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 G 18 20 11 19 0 20 +20 G 19 21 10 20 19 21 +21 C 20 22 9 21 20 22 +22 T 21 23 8 22 21 23 +23 C 22 24 0 23 22 0 +24 C 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 T 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 T 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -0.967 candidate_22277386 pos=16:80198612-80198652 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 G 8 10 0 9 0 0 +10 C 9 11 0 10 0 11 +11 C 10 12 27 11 10 12 +12 A 11 13 26 12 11 13 +13 G 12 14 25 13 12 0 +14 A 13 15 0 14 0 0 +15 A 14 16 23 15 0 16 +16 A 15 17 22 16 15 0 +17 G 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 G 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 T 21 23 16 22 0 23 +23 T 22 24 15 23 22 0 +24 A 23 25 0 24 0 0 +25 C 24 26 13 25 0 26 +26 T 25 27 12 26 25 27 +27 G 26 28 11 27 26 28 +28 A 27 29 0 28 27 0 +29 C 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -1.159 candidate_22278994 pos=16:48190339-48190379 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 G 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 C 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 G 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 G 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 G 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 G 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 A 32 34 0 33 0 34 +34 G 33 35 40 34 33 35 +35 C 34 36 39 35 34 0 +36 G 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 G 38 40 35 39 0 40 +40 C 39 0 34 40 39 0 +40 dG = -0.789 candidate_22279207 pos=16:90183096-90183136 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 G 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 C 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 T 13 15 0 14 0 0 +15 T 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 T 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 T 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 A 22 24 0 23 0 24 +24 C 23 25 36 24 23 25 +25 A 24 26 35 25 24 26 +26 G 25 27 34 26 25 0 +27 A 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 G 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 C 33 35 26 34 0 35 +35 T 34 36 25 35 34 36 +36 G 35 37 24 36 35 37 +37 A 36 38 0 37 36 0 +38 G 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = 0.161 candidate_22279494 pos=16:92122139-92122179 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 G 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 C 10 12 0 11 0 12 +12 C 11 13 33 12 11 13 +13 C 12 14 32 13 12 14 +14 T 13 15 31 14 13 0 +15 G 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 G 21 23 0 22 0 0 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33 16 32 31 33 +33 G 32 34 15 33 32 34 +34 G 33 35 14 34 33 35 +35 T 34 36 13 35 34 36 +36 G 35 37 0 36 35 0 +37 A 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = 0.434 candidate_22283034 pos=16:49153168-49153208 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 G 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 T 10 12 0 11 0 0 +12 A 11 13 0 12 0 13 +13 C 12 14 19 13 12 14 +14 A 13 15 18 14 13 0 +15 G 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 T 17 19 14 18 0 19 +19 G 18 20 13 19 18 20 +20 A 19 21 0 20 19 0 +21 G 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 G 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 G 24 26 0 25 0 0 +26 G 25 27 0 26 0 0 +27 T 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 G 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -2.189 candidate_22283133 pos=16:55104509-55104549 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 G 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 T 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 C 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 T 14 16 0 15 0 0 +16 C 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 T 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 G 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 C 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 T 27 29 0 28 0 29 +29 G 28 30 38 29 28 30 +30 C 29 31 37 30 29 31 +31 C 30 32 36 31 30 0 +32 C 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 G 35 37 31 36 0 37 +37 G 36 38 30 37 36 38 +38 C 37 39 29 38 37 39 +39 T 38 40 0 39 38 0 +40 A 39 0 0 40 0 0 +40 dG = -3.829 candidate_22285544 pos=16:43157945-43157985 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 3 +3 A 2 4 25 3 2 4 +4 A 3 5 24 4 3 5 +5 C 4 6 23 5 4 6 +6 A 5 7 22 6 5 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 G 8 10 19 9 0 10 +10 C 9 11 18 10 9 11 +11 T 10 12 17 11 10 12 +12 G 11 13 16 12 11 0 +13 C 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 C 15 17 12 16 0 17 +17 A 16 18 11 17 16 18 +18 G 17 19 10 18 17 19 +19 C 18 20 9 19 18 0 +20 A 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 T 21 23 6 22 0 23 +23 G 22 24 5 23 22 24 +24 T 23 25 4 24 23 25 +25 T 24 26 3 25 24 26 +26 A 25 27 0 26 25 0 +27 G 26 28 0 27 0 0 +28 T 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 G 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -2.425 candidate_22285837 pos=16:47151351-47151391 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 G 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 T 10 12 0 11 0 0 +12 G 11 13 0 12 0 0 +13 G 12 14 0 13 0 14 +14 C 13 15 29 14 13 15 +15 A 14 16 28 15 14 16 +16 A 15 17 27 16 15 17 +17 A 16 18 26 17 16 18 +18 C 17 19 25 18 17 0 +19 A 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 T 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 G 24 26 18 25 0 26 +26 T 25 27 17 26 25 27 +27 T 26 28 16 27 26 28 +28 T 27 29 15 28 27 29 +29 G 28 30 14 29 28 30 +30 T 29 31 0 30 29 0 +31 A 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 G 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -1.447 candidate_22289175 pos=16:15136403-15136443 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 9 +9 G 8 10 25 9 8 10 +10 G 9 11 24 10 9 11 +11 A 10 12 23 11 10 0 +12 A 11 13 0 12 0 0 +13 A 12 14 21 13 0 14 +14 C 13 15 20 14 13 0 +15 C 14 16 0 15 0 0 +16 T 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 G 19 21 14 20 0 21 +21 T 20 22 13 21 20 0 +22 G 21 23 0 22 0 0 +23 T 22 24 11 23 0 24 +24 C 23 25 10 24 23 25 +25 C 24 26 9 25 24 26 +26 C 25 27 0 26 25 0 +27 T 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +0 dG = 998.226 candidate_22291090 pos=16:31132942-31132982 +40 dG = -1.042 candidate_22292624 pos=16:54121626-54121666 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 G 8 10 0 9 0 0 +10 G 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 C 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 G 13 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0 +20 A 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 C 21 23 0 22 0 23 +23 C 22 24 40 23 22 24 +24 A 23 25 39 24 23 25 +25 G 24 26 38 25 24 26 +26 C 25 27 37 26 25 27 +27 A 26 28 36 27 26 28 +28 A 27 29 35 28 27 0 +29 C 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 T 34 36 28 35 0 36 +36 T 35 37 27 36 35 37 +37 G 36 38 26 37 36 38 +38 C 37 39 25 38 37 39 +39 T 38 40 24 39 38 40 +40 G 39 0 23 40 39 0 +40 dG = -0.904 candidate_22293865 pos=16:55185288-55185328 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 8 +8 A 7 9 16 8 7 9 +9 G 8 10 15 9 8 10 +10 G 9 11 14 10 9 0 +11 A 10 12 0 11 0 0 +12 G 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 C 13 15 10 14 0 15 +15 C 14 16 9 15 14 16 +16 T 15 17 8 16 15 17 +17 A 16 18 0 17 16 0 +18 C 17 19 0 18 0 0 +19 A 18 20 0 19 0 20 +20 C 19 21 36 20 19 21 +21 T 20 22 35 21 20 22 +22 A 21 23 34 22 21 23 +23 T 22 24 33 23 22 24 +24 A 23 25 32 24 23 0 +25 C 24 26 0 25 0 0 +26 C 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 T 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 T 31 33 24 32 0 33 +33 A 32 34 23 33 32 34 +34 T 33 35 22 34 33 35 +35 A 34 36 21 35 34 36 +36 G 35 37 20 36 35 37 +37 A 36 38 0 37 36 0 +38 T 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -2.778 candidate_22294429 pos=16:31104483-31104523 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 8 +8 A 7 9 35 8 7 9 +9 G 8 10 34 9 8 10 +10 G 9 11 33 10 9 0 +11 A 10 12 0 11 0 0 +12 G 11 13 30 12 0 13 +13 C 12 14 29 13 12 14 +14 T 13 15 28 14 13 0 +15 A 14 16 0 15 0 0 +16 A 15 17 26 16 0 17 +17 T 16 18 25 17 16 18 +18 T 17 19 24 18 17 0 +19 A 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 G 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 A 23 25 18 24 0 25 +25 A 24 26 17 25 24 26 +26 T 25 27 16 26 25 0 +27 G 26 28 0 27 0 0 +28 A 27 29 14 28 0 29 +29 G 28 30 13 29 28 30 +30 C 29 31 12 30 29 0 +31 A 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 C 32 34 10 33 0 34 +34 C 33 35 9 34 33 35 +35 T 34 36 8 35 34 36 +36 C 35 37 0 36 35 0 +37 C 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +0 dG = 998.226 candidate_22294609 pos=16:73178356-73178396 +40 dG = -2.408 candidate_22297174 pos=16:60175876-60175916 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 G 8 10 0 9 0 0 +10 G 9 11 0 10 0 11 +11 C 10 12 26 11 10 12 +12 A 11 13 25 12 11 13 +13 A 12 14 24 13 12 14 +14 G 13 15 23 14 13 15 +15 C 14 16 22 15 14 16 +16 A 15 17 21 16 15 0 +17 G 16 18 0 17 0 0 +18 G 17 19 0 18 0 0 +19 G 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 T 20 22 16 21 0 22 +22 G 21 23 15 22 21 23 +23 T 22 24 14 23 22 24 +24 T 23 25 13 24 23 25 +25 T 24 26 12 25 24 26 +26 G 25 27 11 26 25 27 +27 T 26 28 0 27 26 0 +28 T 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -3.135 candidate_22297925 pos=16:46186219-46186259 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 8 +8 A 7 9 30 8 7 9 +9 G 8 10 29 9 8 10 +10 G 9 11 28 10 9 11 +11 C 10 12 27 11 10 12 +12 A 11 13 26 12 11 0 +13 G 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 G 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 G 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 T 25 27 12 26 0 27 +27 G 26 28 11 27 26 28 +28 C 27 29 10 28 27 29 +29 C 28 30 9 29 28 30 +30 T 29 31 8 30 29 31 +31 G 30 32 0 31 30 0 +32 G 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 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38 40 0 39 38 0 +40 G 39 0 0 40 0 0 +40 dG = 0.394 candidate_22298997 pos=16:26100961-26101001 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 G 8 10 0 9 0 10 +10 G 9 11 26 10 9 11 +11 C 10 12 25 11 10 0 +12 C 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 T 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 G 24 26 11 25 0 26 +26 C 25 27 10 26 25 27 +27 A 26 28 0 27 26 0 +28 C 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = 0.274 candidate_22299683 pos=16:10168337-10168377 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 9 +9 G 8 10 18 9 8 10 +10 G 9 11 17 10 9 0 +11 C 10 12 0 11 0 0 +12 C 11 13 0 12 0 0 +13 T 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 T 15 17 0 16 0 0 +17 C 16 18 10 17 0 18 +18 C 17 19 9 18 17 19 +19 A 18 20 0 19 18 0 +20 T 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 G 24 26 0 25 0 0 +26 T 25 27 0 26 0 0 +27 T 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 C 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -2.472 candidate_22300372 pos=16:11141090-11141130 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 G 8 10 0 9 0 0 +10 G 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 T 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 G 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 G 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 G 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 G 20 22 0 21 0 22 +22 G 21 23 38 22 21 23 +23 C 22 24 37 23 22 24 +24 T 23 25 36 24 23 25 +25 C 24 26 35 25 24 0 +26 A 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 G 34 36 25 35 0 36 +36 A 35 37 24 36 35 37 +37 G 36 38 23 37 36 38 +38 C 37 39 22 38 37 39 +39 A 38 40 0 39 38 0 +40 C 39 0 0 40 0 0 +40 dG = -3.561 candidate_22300595 pos=16:42103309-42103349 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 6 +6 A 5 7 18 6 5 7 +7 A 6 8 17 7 6 8 +8 A 7 9 16 8 7 9 +9 G 8 10 15 9 8 0 +10 G 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 T 11 13 0 12 0 0 +13 C 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 C 14 16 9 15 0 16 +16 T 15 17 8 16 15 17 +17 T 16 18 7 17 16 18 +18 T 17 19 6 18 17 19 +19 C 18 20 0 19 18 0 +20 T 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 G 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 A 25 27 0 26 0 27 +27 C 26 28 37 27 26 28 +28 C 27 29 36 28 27 29 +29 A 28 30 35 29 28 0 +30 A 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 T 34 36 29 35 0 36 +36 G 35 37 28 36 35 37 +37 G 36 38 27 37 36 38 +38 A 37 39 0 38 37 0 +39 T 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -2.142 candidate_22300923 pos=16:97165790-97165830 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 G 8 10 0 9 0 0 +10 G 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 T 11 13 0 12 0 0 +13 G 12 14 0 13 0 14 +14 C 13 15 26 14 13 15 +15 A 14 16 25 15 14 16 +16 G 15 17 24 16 15 17 +17 A 16 18 23 17 16 0 +18 C 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 T 22 24 17 23 0 24 +24 C 23 25 16 24 23 25 +25 T 24 26 15 25 24 26 +26 G 25 27 14 26 25 27 +27 A 26 28 0 27 26 0 +28 C 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 G 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -1.695 candidate_22300972 pos=16:31194128-31194168 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 G 8 10 0 9 0 0 +10 G 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 T 11 13 0 12 0 13 +13 G 12 14 26 13 12 14 +14 C 13 15 25 14 13 15 +15 T 14 16 24 15 14 16 +16 T 15 17 23 16 15 17 +17 G 16 18 22 17 16 0 +18 A 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 C 21 23 17 22 0 23 +23 A 22 24 16 23 22 24 +24 G 23 25 15 24 23 25 +25 G 24 26 14 25 24 26 +26 C 25 27 13 26 25 27 +27 A 26 28 0 27 26 0 +28 C 27 29 0 28 0 0 +29 T 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -1.585 candidate_22302074 pos=16:5109235-5109275 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 8 +8 A 7 9 15 8 7 9 +9 G 8 10 14 9 8 0 +10 G 9 11 0 10 0 0 +11 G 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 C 13 15 9 14 0 15 +15 T 14 16 8 15 14 16 +16 G 15 17 0 16 15 0 +17 G 16 18 0 17 0 0 +18 G 17 19 0 18 0 0 +19 G 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 G 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 A 23 25 0 24 0 25 +25 G 24 26 34 25 24 26 +26 A 25 27 33 26 25 27 +27 G 26 28 32 27 26 0 +28 A 27 29 0 28 0 0 +29 T 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 G 30 32 0 31 0 0 +32 C 31 33 27 32 0 33 +33 T 32 34 26 33 32 34 +34 C 33 35 25 34 33 35 +35 A 34 36 0 35 34 0 +36 G 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -5.807 candidate_22302160 pos=16:90124634-90124674 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 9 +9 G 8 10 17 9 8 10 +10 G 9 11 16 10 9 11 +11 G 10 12 15 11 10 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 G 13 15 0 14 0 0 +15 C 14 16 11 15 0 16 +16 C 15 17 10 16 15 17 +17 C 16 18 9 17 16 18 +18 A 17 19 0 18 17 0 +19 G 18 20 34 19 0 20 +20 C 19 21 33 20 19 21 +21 A 20 22 32 21 20 22 +22 G 21 23 31 22 21 23 +23 C 22 24 30 23 22 0 +24 A 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 G 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 G 29 31 23 30 0 31 +31 C 30 32 22 31 30 32 +32 T 31 33 21 32 31 33 +33 G 32 34 20 33 32 34 +34 C 33 35 19 34 33 35 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6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 8 +8 A 7 9 16 8 7 9 +9 G 8 10 15 9 8 10 +10 G 9 11 14 10 9 0 +11 T 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 G 12 14 0 13 0 0 +14 C 13 15 10 14 0 15 +15 C 14 16 9 15 14 16 +16 T 15 17 8 16 15 17 +17 G 16 18 0 17 16 0 +18 C 17 19 0 18 0 0 +19 T 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 A 20 22 0 21 0 22 +22 C 21 23 31 22 21 23 +23 C 22 24 30 23 22 24 +24 A 23 25 29 24 23 0 +25 A 24 26 0 25 0 0 +26 C 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 T 27 29 0 28 0 0 +29 T 28 30 24 29 0 30 +30 G 29 31 23 30 29 31 +31 G 30 32 22 31 30 32 +32 A 31 33 0 32 31 0 +33 A 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -0.665 candidate_22307094 pos=16:13176077-13176117 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 G 8 10 0 9 0 0 +10 G 9 11 0 10 0 0 +11 T 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 T 12 14 0 13 0 0 +14 G 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 T 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 C 25 27 0 26 0 0 +27 C 26 28 0 27 0 0 +28 A 27 29 0 28 0 29 +29 A 28 30 40 29 28 30 +30 G 29 31 39 30 29 31 +31 A 30 32 38 31 30 32 +32 A 31 33 37 32 31 0 +33 G 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 T 36 38 32 37 0 38 +38 T 37 39 31 38 37 39 +39 C 38 40 30 39 38 40 +40 T 39 0 29 40 39 0 +40 dG = -1.026 candidate_22307991 pos=16:34107515-34107555 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 G 8 10 0 9 0 0 +10 G 9 11 0 10 0 0 +11 T 10 12 0 11 0 0 +12 C 11 13 0 12 0 0 +13 T 12 14 0 13 0 0 +14 T 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 T 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 G 17 19 0 18 0 0 +19 G 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 G 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 T 25 27 0 26 0 0 +27 C 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 T 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 T 30 32 0 31 0 32 +32 C 31 33 39 32 31 33 +33 C 32 34 38 33 32 0 +34 T 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 G 37 39 33 38 0 39 +39 G 38 40 32 39 38 40 +40 A 39 0 0 40 39 0 +40 dG = -4.151 candidate_22308271 pos=16:93102076-93102116 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 5 +5 C 4 6 12 5 4 6 +6 A 5 7 11 6 5 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 G 8 10 0 9 0 0 +10 G 9 11 0 10 0 0 +11 T 10 12 6 11 0 12 +12 G 11 13 5 12 11 13 +13 A 12 14 0 13 12 0 +14 G 13 15 0 14 0 15 +15 C 14 16 33 15 14 16 +16 A 15 17 32 16 15 17 +17 G 16 18 31 17 16 18 +18 G 17 19 30 18 17 19 +19 C 18 20 29 19 18 0 +20 T 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 T 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 G 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 T 27 29 0 28 0 0 +29 G 28 30 19 29 0 30 +30 C 29 31 18 30 29 31 +31 C 30 32 17 31 30 32 +32 T 31 33 16 32 31 33 +33 G 32 34 15 33 32 34 +34 G 33 35 0 34 33 0 +35 A 34 36 0 35 0 0 +36 G 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = 0.364 candidate_22308782 pos=16:39186247-39186287 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 5 +5 C 4 6 12 5 4 6 +6 A 5 7 11 6 5 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 G 8 10 0 9 0 0 +10 G 9 11 0 10 0 0 +11 T 10 12 6 11 0 12 +12 G 11 13 5 12 11 13 +13 G 12 14 0 13 12 0 +14 T 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 G 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 G 21 23 0 22 0 0 +23 G 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 G 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 A 26 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32 0 0 +33 G 32 34 28 33 0 34 +34 G 33 35 27 34 33 35 +35 G 34 36 26 35 34 36 +36 T 35 37 0 36 35 0 +37 C 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -1.045 candidate_22309582 pos=16:77139315-77139355 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 G 8 10 0 9 0 0 +10 G 9 11 0 10 0 0 +11 T 10 12 0 11 0 0 +12 T 11 13 0 12 0 13 +13 C 12 14 37 13 12 14 +14 T 13 15 36 14 13 15 +15 T 14 16 35 15 14 16 +16 C 15 17 34 16 15 17 +17 T 16 18 33 17 16 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 G 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 G 21 23 0 22 0 0 +23 G 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 G 25 27 0 26 0 0 +27 T 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 A 32 34 17 33 0 34 +34 G 33 35 16 34 33 35 +35 A 34 36 15 35 34 36 +36 A 35 37 14 36 35 37 +37 G 36 38 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pos=16:93153957-93153997 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 5 +5 C 4 6 13 5 4 6 +6 A 5 7 12 6 5 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 G 8 10 0 9 0 0 +10 T 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 T 11 13 6 12 0 13 +13 G 12 14 5 13 12 14 +14 A 13 15 0 14 13 0 +15 A 14 16 0 15 0 0 +16 G 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 G 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 T 22 24 0 23 0 0 +24 G 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 T 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 T 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -0.821 candidate_22322429 pos=16:10191280-10191320 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 6 +6 A 5 7 24 6 5 7 +7 A 6 8 23 7 6 8 +8 A 7 9 22 8 7 9 +9 G 8 10 21 9 8 10 +10 T 9 11 20 10 9 11 +11 C 10 12 19 11 10 12 +12 T 11 13 18 12 11 0 +13 C 12 14 0 13 0 0 +14 T 13 15 0 14 0 0 +15 G 14 16 0 15 0 0 +16 C 15 17 0 16 0 0 +17 T 16 18 0 17 0 0 +18 G 17 19 12 18 0 19 +19 G 18 20 11 19 18 20 +20 G 19 21 10 20 19 21 +21 C 20 22 9 21 20 22 +22 T 21 23 8 22 21 23 +23 T 22 24 7 23 22 24 +24 T 23 25 6 24 23 25 +25 C 24 26 0 25 24 0 +26 T 25 27 0 26 0 0 +27 T 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 C 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -1.513 candidate_22322736 pos=16:70183950-70183990 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 G 8 10 0 9 0 0 +10 T 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 T 11 13 0 12 0 0 +13 G 12 14 0 13 0 14 +14 G 13 15 34 14 13 15 +15 G 14 16 33 15 14 16 +16 G 15 17 32 16 15 17 +17 T 16 18 31 17 16 0 +18 T 17 19 0 18 0 0 +19 T 18 20 29 19 0 20 +20 G 19 21 28 20 19 21 +21 G 20 22 27 21 20 0 +22 C 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 C 26 28 21 27 0 28 +28 C 27 29 20 28 27 29 +29 A 28 30 19 29 28 0 +30 C 29 31 0 30 0 0 +31 A 30 32 17 31 0 32 +32 T 31 33 16 32 31 33 +33 C 32 34 15 33 32 34 +34 C 33 35 14 34 33 35 +35 T 34 36 0 35 34 0 +36 A 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -0.389 candidate_22324337 pos=16:86170469-86170509 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 G 8 10 0 9 0 0 +10 T 9 11 0 10 0 0 +11 G 10 12 0 11 0 0 +12 A 11 13 0 12 0 13 +13 C 12 14 21 13 12 14 +14 T 13 15 20 14 13 15 +15 A 14 16 19 15 14 0 +16 G 15 17 0 16 0 0 +17 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22 21 23 +23 C 22 24 32 23 22 0 +24 C 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 T 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 G 31 33 23 32 0 33 +33 G 32 34 22 33 32 34 +34 C 33 35 21 34 33 35 +35 T 34 36 20 35 34 0 +36 A 35 37 0 36 0 0 +37 C 36 38 17 37 0 38 +38 A 37 39 16 38 37 39 +39 G 38 40 15 39 38 40 +40 T 39 0 0 40 39 0 +40 dG = -1.96 candidate_22325960 pos=16:88141120-88141160 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 9 +9 G 8 10 30 9 8 10 +10 T 9 11 29 10 9 11 +11 G 10 12 28 11 10 12 +12 C 11 13 27 12 11 13 +13 T 12 14 26 13 12 0 +14 T 13 15 0 14 0 0 +15 C 14 16 23 15 0 16 +16 A 15 17 22 16 15 0 +17 T 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 T 21 23 16 22 0 23 +23 G 22 24 15 23 22 0 +24 C 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 G 25 27 13 26 0 27 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2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 T 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 C 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 G 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 T 28 30 0 29 0 30 +30 C 29 31 39 30 29 31 +31 C 30 32 38 31 30 0 +32 A 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 G 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 G 37 39 31 38 0 39 +39 G 38 40 30 39 38 40 +40 G 39 0 0 40 39 0 +40 dG = -0.926 candidate_22342579 pos=16:44128322-44128362 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 T 8 10 0 9 0 0 +10 A 9 11 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0 16 0 0 +17 A 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 T 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 T 25 27 0 26 0 27 +27 G 26 28 37 27 26 28 +28 A 27 29 36 28 27 29 +29 A 28 30 35 29 28 0 +30 T 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 T 34 36 29 35 0 36 +36 T 35 37 28 36 35 37 +37 C 36 38 27 37 36 38 +38 C 37 39 0 38 37 0 +39 T 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -1.292 candidate_22348223 pos=16:60138660-60138700 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 T 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 A 10 12 0 11 0 12 +12 C 11 13 23 12 11 13 +13 A 12 14 22 13 12 14 +14 G 13 15 21 14 13 15 +15 T 14 16 20 15 14 0 +16 A 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 T 18 20 0 19 0 0 +20 G 19 21 15 20 0 21 +21 C 20 22 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pos=16:60105525-60105565 +1 A 0 2 18 1 0 2 +2 A 1 3 17 2 1 3 +3 A 2 4 16 3 2 0 +4 A 3 5 0 4 0 0 +5 C 4 6 14 5 0 6 +6 A 5 7 13 6 5 7 +7 A 6 8 12 7 6 0 +8 A 7 9 0 8 0 0 +9 T 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 T 11 13 7 12 0 13 +13 T 12 14 6 13 12 14 +14 G 13 15 5 14 13 0 +15 G 14 16 0 15 0 0 +16 T 15 17 3 16 0 17 +17 T 16 18 2 17 16 18 +18 T 17 19 1 18 17 19 +19 T 18 20 0 19 18 0 +20 G 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 A 21 23 0 22 0 23 +23 G 22 24 31 23 22 24 +24 G 23 25 30 24 23 25 +25 C 24 26 29 25 24 0 +26 T 25 27 0 26 0 0 +27 C 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 G 28 30 25 29 0 30 +30 C 29 31 24 30 29 31 +31 C 30 32 23 31 30 32 +32 C 31 33 0 32 31 0 +33 T 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = 0.854 candidate_22356305 pos=16:88124318-88124358 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 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11 13 18 12 11 13 +13 C 12 14 17 13 12 0 +14 A 13 15 0 14 0 0 +15 G 14 16 0 15 0 0 +16 T 15 17 0 16 0 0 +17 G 16 18 13 17 0 18 +18 T 17 19 12 18 17 19 +19 G 18 20 11 19 18 20 +20 C 19 21 0 20 19 0 +21 T 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 G 22 24 0 23 0 0 +24 T 23 25 0 24 0 25 +25 G 24 26 40 25 24 26 +26 G 25 27 39 26 25 27 +27 G 26 28 38 27 26 28 +28 A 27 29 37 28 27 0 +29 T 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 G 35 37 0 36 0 0 +37 T 36 38 28 37 0 38 +38 C 37 39 27 38 37 39 +39 C 38 40 26 39 38 40 +40 C 39 0 25 40 39 0 +40 dG = -0.578 candidate_22358340 pos=16:75187595-75187635 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 4 +4 A 3 5 21 4 3 5 +5 C 4 6 20 5 4 6 +6 A 5 7 19 6 5 7 +7 A 6 8 18 7 6 0 +8 A 7 9 0 8 0 0 +9 T 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 G 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 T 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 T 17 19 7 18 0 19 +19 T 18 20 6 19 18 20 +20 G 19 21 5 20 19 21 +21 T 20 22 4 21 20 22 +22 A 21 23 0 22 21 0 +23 G 22 24 0 23 0 0 +24 C 23 25 0 24 0 25 +25 A 24 26 32 25 24 26 +26 C 25 27 31 26 25 0 +27 A 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 G 30 32 26 31 0 32 +32 T 31 33 25 32 31 33 +33 A 32 34 0 33 32 0 +34 G 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -0.949 candidate_22359397 pos=16:72145410-72145450 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 T 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 T 12 14 0 13 0 0 +14 G 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 T 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 G 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 G 21 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0 23 0 0 +24 G 23 25 0 24 0 0 +25 A 24 26 20 25 0 26 +26 T 25 27 19 26 25 27 +27 G 26 28 18 27 26 28 +28 C 27 29 17 28 27 29 +29 T 28 30 0 29 28 0 +30 G 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -2.148 candidate_22402937 pos=16:87187631-87187671 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 4 +4 A 3 5 15 4 3 5 +5 C 4 6 14 5 4 6 +6 A 5 7 13 6 5 7 +7 A 6 8 12 7 6 0 +8 A 7 9 0 8 0 0 +9 T 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 T 10 12 0 11 0 0 +12 T 11 13 7 12 0 13 +13 T 12 14 6 13 12 14 +14 G 13 15 5 14 13 15 +15 T 14 16 4 15 14 16 +16 G 15 17 0 16 15 0 +17 A 16 18 0 17 0 0 +18 G 17 19 0 18 0 0 +19 T 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 A 22 24 0 23 0 24 +24 G 23 25 32 24 23 25 +25 G 24 26 31 25 24 0 +26 C 25 27 0 26 0 0 +27 C 26 28 0 27 0 0 +28 T 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 C 30 32 25 31 0 32 +32 C 31 33 24 32 31 33 +33 A 32 34 0 33 32 0 +34 C 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -0.379 candidate_22404908 pos=16:52134574-52134614 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 T 8 10 0 9 0 0 +10 G 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 G 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 C 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 G 17 19 0 18 0 0 +19 A 18 20 0 19 0 20 +20 G 19 21 29 20 19 21 +21 C 20 22 28 21 20 22 +22 G 21 23 27 22 21 0 +23 A 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 T 25 27 0 26 0 0 +27 T 26 28 22 27 0 28 +28 G 27 29 21 28 27 29 +29 C 28 30 20 29 28 30 +30 C 29 31 0 30 29 0 +31 T 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -0.44 candidate_22406075 pos=16:60185472-60185512 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 9 +9 T 8 10 35 9 8 10 +10 G 9 11 34 10 9 11 +11 A 10 12 33 11 10 0 +12 A 11 13 0 12 0 0 +13 C 12 14 31 13 0 14 +14 A 13 15 30 14 13 0 +15 A 14 16 0 15 0 0 +16 T 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 T 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 T 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 T 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 T 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 T 29 31 14 30 0 31 +31 G 30 32 13 31 30 0 +32 G 31 33 0 32 0 0 +33 T 32 34 11 33 0 34 +34 C 33 35 10 34 33 35 +35 A 34 36 9 35 34 0 +36 C 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -1.882 candidate_22406780 pos=16:94123970-94124010 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 T 8 10 0 9 0 0 +10 G 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 G 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 T 16 18 0 17 0 0 +18 G 17 19 0 18 0 19 +19 C 18 20 30 19 18 20 +20 C 19 21 29 20 19 21 +21 C 20 22 28 21 20 22 +22 G 21 23 27 22 21 0 +23 G 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 T 25 27 0 26 0 0 +27 T 26 28 22 27 0 28 +28 G 27 29 21 28 27 29 +29 G 28 30 20 29 28 30 +30 G 29 31 19 30 29 31 +31 G 30 32 0 31 30 0 +32 A 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -0.962 candidate_22409580 pos=16:15123716-15123756 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 8 +8 A 7 9 19 8 7 9 +9 T 8 10 18 9 8 10 +10 G 9 11 17 10 9 11 +11 A 10 12 16 11 10 0 +12 C 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 G 13 15 0 14 0 0 +15 T 14 16 0 15 0 0 +16 T 15 17 11 16 0 17 +17 C 16 18 10 17 16 18 +18 A 17 19 9 18 17 19 +19 T 18 20 8 19 18 20 +20 G 19 21 0 20 19 0 +21 T 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 G 22 24 0 23 0 0 +24 G 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 T 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 G 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -1.445 candidate_22409669 pos=16:64127159-64127199 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 T 8 10 0 9 0 0 +10 G 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 C 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 T 13 15 0 14 0 15 +15 C 14 16 28 15 14 16 +16 T 15 17 27 16 15 17 +17 C 16 18 26 17 16 18 +18 A 17 19 25 18 17 19 +19 T 18 20 24 19 18 0 +20 A 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 G 22 24 0 23 0 0 +24 G 23 25 19 24 0 25 +25 T 24 26 18 25 24 26 +26 G 25 27 17 26 25 27 +27 A 26 28 16 27 26 28 +28 G 27 29 15 28 27 29 +29 G 28 30 0 29 28 0 +30 A 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -2.292 candidate_22409934 pos=16:39186056-39186096 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 T 8 10 0 9 0 0 +10 G 9 11 0 10 0 0 +11 A 10 12 0 11 0 12 +12 C 11 13 28 12 11 13 +13 C 12 14 27 13 12 14 +14 C 13 15 26 14 13 15 +15 A 14 16 25 15 14 0 +16 A 15 17 0 16 0 0 +17 T 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 T 24 26 15 25 0 26 +26 G 25 27 14 26 25 27 +27 G 26 28 13 27 26 28 +28 G 27 29 12 28 27 29 +29 C 28 30 0 29 28 0 +30 T 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 G 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -1.389 candidate_22410844 pos=16:71175515-71175555 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 T 8 10 0 9 0 0 +10 G 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 C 11 13 0 12 0 0 +13 T 12 14 0 13 0 0 +14 T 13 15 0 14 0 0 +15 T 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 T 17 19 0 18 0 19 +19 G 18 20 27 19 18 20 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32 25 0 26 +26 T 25 27 31 26 25 0 +27 C 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 A 30 32 26 31 0 32 +32 G 31 33 25 32 31 0 +33 G 32 34 0 33 0 0 +34 C 33 35 23 34 0 35 +35 T 34 36 22 35 34 36 +36 G 35 37 0 36 35 0 +37 C 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -1.918 candidate_22412801 pos=16:66173972-66174012 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 3 +3 A 2 4 14 3 2 4 +4 A 3 5 13 4 3 5 +5 C 4 6 12 5 4 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 T 8 10 0 9 0 0 +10 G 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 G 11 13 5 12 0 13 +13 T 12 14 4 13 12 14 +14 T 13 15 3 14 13 15 +15 A 14 16 0 15 14 0 +16 A 15 17 0 16 0 17 +17 G 16 18 32 17 16 18 +18 C 17 19 31 18 17 19 +19 C 18 20 30 19 18 0 +20 A 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 G 25 27 0 26 0 0 +27 T 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 G 29 31 19 30 0 31 +31 G 30 32 18 31 30 32 +32 C 31 33 17 32 31 33 +33 A 32 34 0 33 32 0 +34 A 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -1.825 candidate_22414716 pos=16:6125809-6125849 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 5 +5 C 4 6 14 5 4 6 +6 A 5 7 13 6 5 7 +7 A 6 8 12 7 6 0 +8 A 7 9 0 8 0 0 +9 T 8 10 0 9 0 0 +10 G 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 T 11 13 7 12 0 13 +13 T 12 14 6 13 12 14 +14 G 13 15 5 14 13 15 +15 G 14 16 0 15 14 0 +16 C 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 G 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 G 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 G 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 G 30 32 0 31 0 32 +32 C 31 33 39 32 31 33 +33 C 32 34 38 33 32 0 +34 T 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 G 37 39 33 38 0 39 +39 G 38 40 32 39 38 40 +40 T 39 0 0 40 39 0 +40 dG = -1.472 candidate_22416928 pos=16:55125756-55125796 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 T 8 10 0 9 0 10 +10 G 9 11 24 10 9 11 +11 C 10 12 23 11 10 12 +12 A 11 13 22 12 11 13 +13 T 12 14 21 13 12 0 +14 C 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 T 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 T 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 A 20 22 13 21 0 22 +22 T 21 23 12 22 21 23 +23 G 22 24 11 23 22 24 +24 C 23 25 10 24 23 25 +25 T 24 26 0 25 24 0 +26 A 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 G 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -0.442 candidate_22420280 pos=16:94159288-94159328 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 T 8 10 0 9 0 0 +10 G 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 T 11 13 40 12 0 13 +13 T 12 14 39 13 12 14 +14 C 13 15 38 14 13 15 +15 C 14 16 37 15 14 16 +16 T 15 17 36 16 15 0 +17 C 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 G 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 T 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 A 35 37 16 36 0 37 +37 G 36 38 15 37 36 38 +38 G 37 39 14 38 37 39 +39 A 38 40 13 39 38 40 +40 A 39 0 12 40 39 0 +40 dG = -0.956 candidate_22422286 pos=16:57100406-57100446 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 4 +4 A 3 5 35 4 3 5 +5 C 4 6 34 5 4 6 +6 A 5 7 33 6 5 7 +7 A 6 8 32 7 6 0 +8 A 7 9 28 8 0 9 +9 T 8 10 27 9 8 10 +10 G 9 11 26 10 9 11 +11 G 10 12 25 11 10 0 +12 A 11 13 0 12 0 0 +13 G 12 14 0 13 0 0 +14 T 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 T 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 G 19 21 0 20 0 0 +21 G 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 C 24 26 11 25 0 26 +26 C 25 27 10 26 25 27 +27 A 26 28 9 27 26 28 +28 T 27 29 8 28 27 0 +29 A 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 T 31 33 7 32 0 33 +33 T 32 34 6 33 32 34 +34 G 33 35 5 34 33 35 +35 T 34 36 4 35 34 36 +36 G 35 37 0 36 35 0 +37 T 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -2.378 candidate_22423546 pos=16:41192808-41192848 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 4 +4 A 3 5 21 4 3 5 +5 C 4 6 20 5 4 6 +6 A 5 7 19 6 5 7 +7 A 6 8 18 7 6 8 +8 A 7 9 17 8 7 9 +9 T 8 10 16 9 8 0 +10 G 9 11 0 10 0 0 +11 G 10 12 0 11 0 0 +12 C 11 13 0 12 0 0 +13 C 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 A 15 17 9 16 0 17 +17 T 16 18 8 17 16 18 +18 T 17 19 7 18 17 19 +19 T 18 20 6 19 18 20 +20 G 19 21 5 20 19 21 +21 T 20 22 4 21 20 22 +22 C 21 23 0 22 21 0 +23 A 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 G 25 27 0 26 0 0 +27 C 26 28 0 27 0 0 +28 T 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 C 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -0.665 candidate_22427785 pos=16:65176726-65176766 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 5 +5 C 4 6 31 5 4 6 +6 A 5 7 30 6 5 0 +7 A 6 8 0 7 0 0 +8 A 7 9 28 8 0 9 +9 T 8 10 27 9 8 10 +10 G 9 11 26 10 9 0 +11 T 10 12 0 11 0 0 +12 A 11 13 24 12 0 13 +13 G 12 14 23 13 12 0 +14 A 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 C 15 17 0 16 0 0 +17 T 16 18 0 17 0 0 +18 G 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 G 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 C 22 24 13 23 0 24 +24 T 23 25 12 24 23 0 +25 T 24 26 0 25 0 0 +26 C 25 27 10 26 0 27 +27 A 26 28 9 27 26 28 +28 T 27 29 8 28 27 0 +29 G 28 30 0 29 0 0 +30 T 29 31 6 30 0 31 +31 G 30 32 5 31 30 32 +32 A 31 33 0 32 31 0 +33 G 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -0.979 candidate_22431224 pos=16:56124062-56124102 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 T 8 10 0 9 0 0 +10 G 9 11 0 10 0 0 +11 T 10 12 0 11 0 0 +12 G 11 13 0 12 0 0 +13 C 12 14 0 13 0 0 +14 T 13 15 0 14 0 0 +15 T 14 16 0 15 0 0 +16 T 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 T 18 20 0 19 0 20 +20 G 19 21 38 20 19 21 +21 G 20 22 37 21 20 22 +22 C 21 23 36 22 21 0 +23 T 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 G 24 26 0 25 0 0 +26 T 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 T 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 G 35 37 22 36 0 37 +37 C 36 38 21 37 36 38 +38 C 37 39 20 38 37 39 +39 C 38 40 0 39 38 0 +40 A 39 0 0 40 0 0 +40 dG = -1.901 candidate_22431606 pos=16:11140939-11140979 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 8 +8 A 7 9 20 8 7 9 +9 T 8 10 19 9 8 10 +10 G 9 11 18 10 9 11 +11 T 10 12 17 11 10 12 +12 G 11 13 16 12 11 0 +13 G 12 14 0 13 0 0 +14 T 13 15 0 14 0 0 +15 G 14 16 0 15 0 0 +16 C 15 17 12 16 0 17 +17 A 16 18 11 17 16 18 +18 C 17 19 10 18 17 19 +19 A 18 20 9 19 18 20 +20 T 19 21 8 20 19 21 +21 C 20 22 0 21 20 0 +22 T 21 23 0 22 0 0 +23 T 22 24 0 23 0 0 +24 T 23 25 0 24 0 25 +25 A 24 26 33 25 24 26 +26 C 25 27 32 26 25 0 +27 T 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 G 31 33 26 32 0 33 +33 T 32 34 25 33 32 34 +34 A 33 35 0 34 33 0 +35 C 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -2.179 candidate_22431610 pos=16:13150836-13150876 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 T 8 10 0 9 0 0 +10 G 9 11 0 10 0 0 +11 T 10 12 0 11 0 0 +12 G 11 13 0 12 0 0 +13 G 12 14 0 13 0 0 +14 T 13 15 0 14 0 15 +15 G 14 16 25 15 14 16 +16 G 15 17 24 16 15 17 +17 C 16 18 23 17 16 0 +18 C 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 G 22 24 17 23 0 24 +24 C 23 25 16 24 23 25 +25 C 24 26 15 25 24 26 +26 C 25 27 0 26 25 0 +27 T 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 T 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -3.924 candidate_22432810 pos=16:10143517-10143557 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 8 +8 A 7 9 32 8 7 9 +9 T 8 10 31 9 8 10 +10 G 9 11 30 10 9 11 +11 T 10 12 29 11 10 12 +12 T 11 13 28 12 11 13 +13 A 12 14 27 13 12 14 +14 T 13 15 26 14 13 15 +15 C 14 16 25 15 14 0 +16 A 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 G 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 G 23 25 0 24 0 0 +25 G 24 26 15 25 0 26 +26 A 25 27 14 26 25 27 +27 T 26 28 13 27 26 28 +28 A 27 29 12 28 27 29 +29 A 28 30 11 29 28 30 +30 C 29 31 10 30 29 31 +31 A 30 32 9 31 30 32 +32 T 31 33 8 32 31 33 +33 C 32 34 0 33 32 0 +34 C 33 35 0 34 0 0 +35 C 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -2.242 candidate_22439916 pos=16:90141470-90141510 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 T 8 10 0 9 0 0 +10 T 9 11 0 10 0 0 +11 A 10 12 0 11 0 12 +12 C 11 13 26 12 11 13 +13 T 12 14 25 13 12 14 +14 G 13 15 24 14 13 15 +15 G 14 16 23 15 14 0 +16 G 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 G 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 G 21 23 0 22 0 0 +23 C 22 24 15 23 0 24 +24 C 23 25 14 24 23 25 +25 A 24 26 13 25 24 26 +26 G 25 27 12 26 25 27 +27 G 26 28 0 27 26 0 +28 A 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -0.851 candidate_22442846 pos=16:73115936-73115976 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 5 +5 C 4 6 21 5 4 6 +6 A 5 7 20 6 5 7 +7 A 6 8 19 7 6 8 +8 A 7 9 18 8 7 0 +9 T 8 10 0 9 0 0 +10 T 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 T 11 13 0 12 0 0 +13 C 12 14 0 13 0 0 +14 T 13 15 0 14 0 0 +15 G 14 16 0 15 0 0 +16 G 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 T 17 19 8 18 0 19 +19 T 18 20 7 19 18 20 +20 T 19 21 6 20 19 21 +21 G 20 22 5 21 20 22 +22 G 21 23 0 22 21 0 +23 A 22 24 0 23 0 0 +24 G 23 25 0 24 0 25 +25 A 24 26 34 25 24 26 +26 G 25 27 33 26 25 27 +27 A 26 28 32 27 26 0 +28 T 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 T 31 33 27 32 0 33 +33 C 32 34 26 33 32 34 +34 T 33 35 25 34 33 35 +35 G 34 36 0 35 34 0 +36 T 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -0.512 candidate_22445629 pos=16:16131714-16131754 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 4 +4 A 3 5 20 4 3 5 +5 C 4 6 19 5 4 6 +6 A 5 7 18 6 5 7 +7 A 6 8 17 7 6 0 +8 A 7 9 0 8 0 0 +9 T 8 10 0 9 0 0 +10 T 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 C 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 T 16 18 7 17 0 18 +18 T 17 19 6 18 17 19 +19 G 18 20 5 19 18 20 +20 T 19 21 4 20 19 21 +21 C 20 22 0 21 20 0 +22 T 21 23 0 22 0 0 +23 T 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 C 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 G 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -1.192 candidate_22446077 pos=16:44104803-44104843 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 T 8 10 0 9 0 0 +10 T 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 G 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 G 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 T 17 19 0 18 0 19 +19 G 18 20 33 19 18 20 +20 A 19 21 32 20 19 21 +21 C 20 22 31 21 20 22 +22 A 21 23 30 22 21 0 +23 C 22 24 0 23 0 0 +24 G 23 25 0 24 0 0 +25 G 24 26 0 25 0 0 +26 T 25 27 0 26 0 0 +27 T 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 T 29 31 22 30 0 31 +31 G 30 32 21 31 30 32 +32 T 31 33 20 32 31 33 +33 C 32 34 19 33 32 34 +34 T 33 35 0 34 33 0 +35 G 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = 0.781 candidate_22448911 pos=16:84178196-84178236 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 4 +4 A 3 5 17 4 3 5 +5 C 4 6 16 5 4 6 +6 A 5 7 15 6 5 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 T 8 10 0 9 0 0 +10 T 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 T 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 T 14 16 6 15 0 16 +16 G 15 17 5 16 15 17 +17 T 16 18 4 17 16 18 +18 C 17 19 0 18 17 0 +19 C 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 T 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 C 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -3.461 candidate_22451921 pos=16:13142802-13142842 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 T 8 10 0 9 0 0 +10 T 9 11 0 10 0 0 +11 G 10 12 0 11 0 0 +12 A 11 13 0 12 0 13 +13 G 12 14 23 13 12 14 +14 G 13 15 22 14 13 15 +15 C 14 16 21 15 14 0 +16 A 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 G 17 19 0 18 0 0 +19 G 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 G 20 22 15 21 0 22 +22 C 21 23 14 22 21 23 +23 C 22 24 13 23 22 24 +24 A 23 25 0 24 23 0 +25 C 24 26 0 25 0 0 +26 C 25 27 0 26 0 27 +27 G 26 28 39 27 26 28 +28 A 27 29 38 28 27 29 +29 A 28 30 37 29 28 30 +30 T 29 31 36 30 29 0 +31 G 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 A 35 37 30 36 0 37 +37 T 36 38 29 37 36 38 +38 T 37 39 28 38 37 39 +39 C 38 40 27 39 38 40 +40 C 39 0 0 40 39 0 +40 dG = -2.228 candidate_22454116 pos=16:6181586-6181626 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 T 8 10 0 9 0 0 +10 T 9 11 0 10 0 0 +11 G 10 12 0 11 0 0 +12 G 11 13 0 12 0 0 +13 G 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 T 14 16 0 15 0 16 +16 A 15 17 31 16 15 17 +17 C 16 18 30 17 16 18 +18 T 17 19 29 18 17 19 +19 G 18 20 28 19 18 20 +20 G 19 21 27 20 19 21 +21 G 20 22 26 21 20 0 +22 A 21 23 0 22 0 0 +23 T 22 24 0 23 0 0 +24 G 23 25 0 24 0 0 +25 G 24 26 0 25 0 0 +26 C 25 27 21 26 0 27 +27 T 26 28 20 27 26 28 +28 C 27 29 19 28 27 29 +29 A 28 30 18 29 28 30 +30 G 29 31 17 30 29 31 +31 T 30 32 16 31 30 32 +32 G 31 33 0 32 31 0 +33 G 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -2.478 candidate_22455527 pos=16:12145387-12145427 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 T 8 10 0 9 0 0 +10 T 9 11 0 10 0 0 +11 G 10 12 0 11 0 0 +12 T 11 13 0 12 0 13 +13 G 12 14 27 13 12 14 +14 T 13 15 26 14 13 15 +15 C 14 16 25 15 14 16 +16 A 15 17 24 16 15 17 +17 G 16 18 23 17 16 18 +18 A 17 19 22 18 17 0 +19 G 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 T 21 23 18 22 0 23 +23 C 22 24 17 23 22 24 +24 T 23 25 16 24 23 25 +25 G 24 26 15 25 24 26 +26 G 25 27 14 26 25 27 +27 C 26 28 13 27 26 28 +28 T 27 29 0 28 27 0 +29 A 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 G 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -0.539 candidate_22461655 pos=16:76185390-76185430 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 A 7 9 0 8 0 0 +9 T 8 10 0 9 0 0 +10 T 9 11 0 10 0 0 +11 T 10 12 0 11 0 0 +12 C 11 13 0 12 0 0 +13 T 12 14 0 13 0 0 +14 G 13 15 0 14 0 15 +15 G 14 16 36 15 14 16 +16 G 15 17 35 16 15 17 +17 G 16 18 34 17 16 0 +18 T 17 19 0 18 0 0 +19 G 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 G 25 27 0 26 0 0 +27 C 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 T 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 C 33 35 17 34 0 35 +35 C 34 36 16 35 34 36 +36 C 35 37 15 36 35 37 +37 T 36 38 0 37 36 0 +38 G 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -1.782 candidate_22462363 pos=16:38165907-38165947 +1 A 0 2 28 1 0 2 +2 A 1 3 27 2 1 3 +3 A 2 4 26 3 2 4 +4 A 3 5 25 4 3 5 +5 C 4 6 24 5 4 6 +6 A 5 7 23 6 5 0 +7 A 6 8 0 7 0 0 +8 A 7 9 20 8 0 9 +9 T 8 10 19 9 8 10 +10 T 9 11 18 10 9 11 +11 T 10 12 17 11 10 0 +12 G 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 G 13 15 0 14 0 0 +15 G 14 16 0 15 0 0 +16 T 15 17 0 16 0 0 +17 G 16 18 11 17 0 18 +18 A 17 19 10 18 17 19 +19 A 18 20 9 19 18 20 +20 T 19 21 8 20 19 0 +21 C 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 T 22 24 6 23 0 24 +24 G 23 25 5 24 23 25 +25 T 24 26 4 25 24 26 +26 T 25 27 3 26 25 27 +27 T 26 28 2 27 26 28 +28 T 27 29 1 28 27 29 +29 A 28 30 0 29 28 0 +30 C 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = 0.461 candidate_22478627 pos=16:67150981-67151021 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 C 12 14 0 13 0 0 +14 A 13 15 0 14 0 15 +15 A 14 16 24 15 14 16 +16 G 15 17 23 16 15 17 +17 T 16 18 22 17 16 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 A 21 23 17 22 0 23 +23 C 22 24 16 23 22 24 +24 T 23 25 15 24 23 25 +25 A 24 26 0 25 24 0 +26 G 25 27 0 26 0 0 +27 C 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 T 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 C 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = 1.684 candidate_22481196 pos=16:97166331-97166371 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 A 10 12 0 11 0 12 +12 A 11 13 26 12 11 13 +13 G 12 14 25 13 12 0 +14 A 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 T 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 C 24 26 13 25 0 26 +26 T 25 27 12 26 25 27 +27 C 26 28 0 27 26 0 +28 C 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 C 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -0.512 candidate_22482990 pos=16:34149365-34149405 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 7 +7 A 6 8 21 7 6 8 +8 C 7 9 20 8 7 9 +9 A 8 10 19 9 8 10 +10 A 9 11 18 10 9 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 T 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 T 14 16 0 15 0 0 +16 C 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 T 17 19 10 18 0 19 +19 T 18 20 9 19 18 20 +20 G 19 21 8 20 19 21 +21 T 20 22 7 21 20 22 +22 C 21 23 0 22 21 0 +23 A 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 T 25 27 0 26 0 0 +27 C 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 T 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 G 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -1.722 candidate_22483304 pos=16:14130104-14130144 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 T 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 C 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 G 22 24 0 23 0 24 +24 C 23 25 35 24 23 25 +25 A 24 26 34 25 24 26 +26 C 25 27 33 26 25 27 +27 T 26 28 32 27 26 0 +28 C 27 29 0 28 0 0 +29 T 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 G 30 32 0 31 0 0 +32 G 31 33 27 32 0 33 +33 G 32 34 26 33 32 34 +34 T 33 35 25 34 33 35 +35 G 34 36 24 35 34 36 +36 A 35 37 0 36 35 0 +37 T 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -1.909 candidate_22483415 pos=16:96191713-96191753 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 T 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 T 14 16 0 15 0 0 +16 T 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 G 19 21 0 20 0 21 +21 C 20 22 31 21 20 22 +22 A 21 23 30 22 21 23 +23 C 22 24 29 23 22 0 +24 T 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 T 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 G 28 30 23 29 0 30 +30 T 29 31 22 30 29 31 +31 G 30 32 21 31 30 32 +32 A 31 33 0 32 31 0 +33 G 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 G 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = 1.984 candidate_22486781 pos=16:28140215-28140255 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 C 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 T 14 16 0 15 0 0 +16 C 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 A 17 19 0 18 0 19 +19 A 18 20 29 19 18 20 +20 G 19 21 28 20 19 0 +21 C 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 C 25 27 0 26 0 0 +27 C 26 28 0 27 0 0 +28 C 27 29 20 28 0 29 +29 T 28 30 19 29 28 30 +30 C 29 31 0 30 29 0 +31 A 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -3.316 candidate_22487831 pos=16:20136212-20136252 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 10 +10 A 9 11 38 10 9 11 +11 A 10 12 37 11 10 12 +12 C 11 13 36 12 11 13 +13 C 12 14 35 13 12 0 +14 A 13 15 0 14 0 0 +15 C 14 16 33 15 0 16 +16 T 15 17 32 16 15 17 +17 A 16 18 31 17 16 18 +18 A 17 19 30 18 17 0 +19 G 18 20 0 19 0 0 +20 G 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 T 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 T 29 31 18 30 0 31 +31 T 30 32 17 31 30 32 +32 A 31 33 16 32 31 33 +33 G 32 34 15 33 32 0 +34 G 33 35 0 34 0 0 +35 G 34 36 13 35 0 36 +36 G 35 37 12 36 35 37 +37 T 36 38 11 37 36 38 +38 T 37 39 10 38 37 39 +39 C 38 40 0 39 38 0 +40 T 39 0 0 40 0 0 +40 dG = 0.444 candidate_22488479 pos=16:4169917-4169957 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 C 11 13 0 12 0 0 +13 T 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 T 15 17 0 16 0 0 +17 T 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 C 20 22 0 21 0 22 +22 C 21 23 28 22 21 23 +23 A 22 24 27 23 22 0 +24 G 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 T 26 28 23 27 0 28 +28 G 27 29 22 28 27 29 +29 T 28 30 0 29 28 0 +30 C 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -5.131 candidate_22488840 pos=16:40123532-40123572 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 C 11 13 0 12 0 0 +13 T 12 14 0 13 0 0 +14 T 13 15 0 14 0 0 +15 C 14 16 0 15 0 16 +16 G 15 17 32 16 15 17 +17 C 16 18 31 17 16 18 +18 T 17 19 30 18 17 19 +19 T 18 20 29 19 18 20 +20 A 19 21 28 20 19 21 +21 G 20 22 27 21 20 22 +22 G 21 23 26 22 21 0 +23 T 22 24 0 23 0 0 +24 G 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 C 25 27 22 26 0 27 +27 C 26 28 21 27 26 28 +28 T 27 29 20 28 27 29 +29 A 28 30 19 29 28 30 +30 A 29 31 18 30 29 31 +31 G 30 32 17 31 30 32 +32 C 31 33 16 32 31 33 +33 A 32 34 0 33 32 0 +34 A 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = 0.078 candidate_22489854 pos=16:15135210-15135250 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 8 +8 C 7 9 35 8 7 9 +9 A 8 10 34 9 8 10 +10 A 9 11 33 10 9 11 +11 A 10 12 32 11 10 0 +12 G 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 G 13 15 0 14 0 0 +15 G 14 16 0 15 0 0 +16 G 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 T 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 G 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 T 31 33 11 32 0 33 +33 T 32 34 10 33 32 34 +34 T 33 35 9 34 33 35 +35 G 34 36 8 35 34 36 +36 G 35 37 0 36 35 0 +37 G 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -1.825 candidate_22490642 pos=16:96113584-96113624 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 A 10 12 0 11 0 12 +12 G 11 13 23 12 11 13 +13 C 12 14 22 13 12 14 +14 T 13 15 21 14 13 0 +15 T 14 16 0 15 0 0 +16 C 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 A 20 22 14 21 0 22 +22 G 21 23 13 22 21 23 +23 C 22 24 12 23 22 24 +24 A 23 25 0 24 23 0 +25 T 24 26 0 25 0 0 +26 C 25 27 0 26 0 0 +27 C 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 A 29 31 0 30 0 31 +31 G 30 32 38 31 30 32 +32 C 31 33 37 32 31 0 +33 A 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 C 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 G 36 38 32 37 0 38 +38 C 37 39 31 38 37 39 +39 A 38 40 0 39 38 0 +40 C 39 0 0 40 0 0 +40 dG = -0.929 candidate_22491482 pos=16:97160493-97160533 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 G 11 13 0 12 0 0 +13 T 12 14 0 13 0 14 +14 G 13 15 26 14 13 15 +15 C 14 16 25 15 14 16 +16 T 15 17 24 16 15 0 +17 G 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 T 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 A 23 25 16 24 0 25 +25 G 24 26 15 25 24 26 +26 C 25 27 14 26 25 27 +27 A 26 28 0 27 26 0 +28 G 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 G 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = 0.344 candidate_22494369 pos=16:15155435-15155475 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 T 11 13 0 12 0 0 +13 T 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 T 14 16 0 15 0 16 +16 G 15 17 22 16 15 17 +17 C 16 18 21 17 16 0 +18 C 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 G 20 22 17 21 0 22 +22 C 21 23 16 22 21 23 +23 T 22 24 0 23 22 0 +24 T 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 G 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 T 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -3.192 candidate_22501160 pos=16:45181676-45181716 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 C 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 A 18 20 0 19 0 20 +20 C 19 21 32 20 19 21 +21 A 20 22 31 21 20 22 +22 C 21 23 30 22 21 23 +23 A 22 24 29 23 22 0 +24 A 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 G 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 T 28 30 23 29 0 30 +30 G 29 31 22 30 29 31 +31 T 30 32 21 31 30 32 +32 G 31 33 20 32 31 33 +33 A 32 34 0 33 32 0 +34 T 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = 0.544 candidate_22510637 pos=16:90188453-90188493 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 A 16 18 0 17 0 18 +18 C 17 19 26 18 17 19 +19 T 18 20 25 19 18 0 +20 C 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 G 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 A 24 26 19 25 0 26 +26 G 25 27 18 26 25 27 +27 C 26 28 0 27 26 0 +28 T 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = 0.624 candidate_22513714 pos=16:92173690-92173730 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 A 19 21 0 20 0 21 +21 A 20 22 29 21 20 22 +22 C 21 23 28 22 21 0 +23 C 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 G 27 29 22 28 0 29 +29 T 28 30 21 29 28 30 +30 C 29 31 0 30 29 0 +31 C 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = 0.344 candidate_22516171 pos=16:94158568-94158608 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 C 26 28 0 27 0 0 +28 T 27 29 0 28 0 29 +29 G 28 30 38 29 28 30 +30 G 29 31 37 30 29 0 +31 T 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 C 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 C 36 38 30 37 0 38 +38 C 37 39 29 38 37 39 +39 T 38 40 0 39 38 0 +40 C 39 0 0 40 0 0 +40 dG = -1.222 candidate_22518786 pos=16:94100674-94100714 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 C 19 21 0 20 0 21 +21 A 20 22 32 21 20 22 +22 A 21 23 31 22 21 23 +23 C 22 24 30 23 22 24 +24 A 23 25 29 24 23 0 +25 A 24 26 0 25 0 0 +26 C 25 27 0 26 0 0 +27 C 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 T 28 30 24 29 0 30 +30 G 29 31 23 30 29 31 +31 T 30 32 22 31 30 32 +32 T 31 33 21 32 31 33 +33 C 32 34 0 33 32 0 +34 T 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = 1.114 candidate_22518902 pos=16:75105564-75105604 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 A 17 19 0 18 0 19 +19 A 18 20 32 19 18 20 +20 C 19 21 31 20 19 0 +21 A 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 T 25 27 0 26 0 0 +27 C 26 28 0 27 0 0 +28 T 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 G 30 32 20 31 0 32 +32 T 31 33 19 32 31 33 +33 G 32 34 0 33 32 0 +34 C 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = 0.471 candidate_22519056 pos=16:94128515-94128555 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 A 17 19 0 18 0 19 +19 A 18 20 34 19 18 20 +20 C 19 21 33 20 19 21 +21 A 20 22 32 21 20 0 +22 A 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 C 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 T 27 29 0 28 0 0 +29 T 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 T 31 33 21 32 0 33 +33 G 32 34 20 33 32 34 +34 T 33 35 19 34 33 35 +35 G 34 36 0 35 34 0 +36 G 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -1.649 candidate_22519488 pos=16:80166974-80167014 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 20 +20 C 19 21 29 20 19 21 +21 A 20 22 28 21 20 22 +22 C 21 23 27 22 21 0 +23 C 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 T 25 27 0 26 0 0 +27 G 26 28 22 27 0 28 +28 T 27 29 21 28 27 29 +29 G 28 30 20 29 28 30 +30 A 29 31 0 30 29 0 +31 T 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 G 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -0.509 candidate_22519521 pos=16:32145524-32145564 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 20 +20 C 19 21 32 20 19 21 +21 A 20 22 31 21 20 22 +22 G 21 23 30 22 21 0 +23 A 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 G 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 C 29 31 22 30 0 31 +31 T 30 32 21 31 30 32 +32 G 31 33 20 32 31 33 +33 G 32 34 0 33 32 0 +34 G 33 35 0 34 0 0 +35 C 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -0.381 candidate_22519965 pos=16:96109738-96109778 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 G 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 A 21 23 0 22 0 23 +23 G 22 24 40 23 22 24 +24 C 23 25 39 24 23 25 +25 T 24 26 38 25 24 26 +26 A 25 27 37 26 25 27 +27 C 26 28 36 27 26 28 +28 T 27 29 35 28 27 0 +29 G 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 G 34 36 28 35 0 36 +36 G 35 37 27 36 35 37 +37 T 36 38 26 37 36 38 +38 G 37 39 25 38 37 39 +39 G 38 40 24 39 38 40 +40 C 39 0 23 40 39 0 +40 dG = 0.191 candidate_22520899 pos=16:38131343-38131383 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 A 18 20 0 19 0 20 +20 G 19 21 34 20 19 21 +21 T 20 22 33 21 20 22 +22 C 21 23 32 22 21 0 +23 C 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 G 24 26 0 25 0 0 +26 T 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 G 31 33 22 32 0 33 +33 A 32 34 21 33 32 34 +34 C 33 35 20 34 33 35 +35 C 34 36 0 35 34 0 +36 A 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -4.078 candidate_22522157 pos=16:6119212-6119252 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 7 +7 A 6 8 23 7 6 8 +8 C 7 9 22 8 7 9 +9 A 8 10 21 9 8 10 +10 A 9 11 20 10 9 11 +11 C 10 12 19 11 10 12 +12 A 11 13 18 12 11 0 +13 A 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 C 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 T 17 19 12 18 0 19 +19 G 18 20 11 19 18 20 +20 T 19 21 10 20 19 21 +21 T 20 22 9 21 20 22 +22 G 21 23 8 22 21 23 +23 T 22 24 7 23 22 24 +24 A 23 25 0 24 23 0 +25 A 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 T 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 G 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -3.215 candidate_22522176 pos=16:75109734-75109774 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 A 14 16 0 15 0 16 +16 C 15 17 33 16 15 17 +17 T 16 18 32 17 16 18 +18 C 17 19 31 18 17 19 +19 C 18 20 30 19 18 20 +20 A 19 21 29 20 19 0 +21 A 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 T 28 30 20 29 0 30 +30 G 29 31 19 30 29 31 +31 G 30 32 18 31 30 32 +32 A 31 33 17 32 31 33 +33 G 32 34 16 33 32 34 +34 A 33 35 0 34 33 0 +35 A 34 36 0 35 0 0 +36 G 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = 0.011 candidate_22523023 pos=16:35115313-35115353 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 A 17 19 0 18 0 19 +19 C 18 20 37 19 18 20 +20 C 19 21 36 20 19 21 +21 T 20 22 35 21 20 0 +22 A 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 G 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 A 34 36 21 35 0 36 +36 G 35 37 20 36 35 37 +37 G 36 38 19 37 36 38 +38 C 37 39 0 38 37 0 +39 A 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -2.584 candidate_22525042 pos=16:9111319-9111359 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 T 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 G 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 A 23 25 0 24 0 25 +25 G 24 26 38 25 24 26 +26 C 25 27 37 26 25 0 +27 A 26 28 0 27 0 0 +28 G 27 29 35 28 0 29 +29 C 28 30 34 29 28 0 +30 A 29 31 0 30 0 0 +31 G 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 G 33 35 29 34 0 35 +35 C 34 36 28 35 34 0 +36 A 35 37 0 36 0 0 +37 G 36 38 26 37 0 38 +38 C 37 39 25 38 37 39 +39 A 38 40 0 39 38 0 +40 A 39 0 0 40 0 0 +40 dG = -2.538 candidate_22526849 pos=16:12172836-12172876 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 G 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 A 15 17 0 16 0 17 +17 C 16 18 28 17 16 18 +18 A 17 19 27 18 17 19 +19 C 18 20 26 19 18 20 +20 A 19 21 25 20 19 0 +21 C 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 G 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 T 24 26 20 25 0 26 +26 G 25 27 19 26 25 27 +27 T 26 28 18 27 26 28 +28 G 27 29 17 28 27 29 +29 G 28 30 0 29 28 0 +30 T 29 31 0 30 0 0 +31 A 30 32 0 31 0 32 +32 G 31 33 39 32 31 33 +33 G 32 34 38 33 32 0 +34 G 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 C 37 39 33 38 0 39 +39 C 38 40 32 39 38 40 +40 A 39 0 0 40 39 0 +40 dG = -0.496 candidate_22528041 pos=16:23191959-23191999 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 G 12 14 0 13 0 0 +14 T 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 C 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 T 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 T 22 24 0 23 0 0 +24 G 23 25 0 24 0 0 +25 C 24 26 0 25 0 26 +26 C 25 27 33 26 25 27 +27 G 26 28 32 27 26 0 +28 T 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 C 31 33 27 32 0 33 +33 G 32 34 26 33 32 34 +34 A 33 35 0 34 33 0 +35 T 34 36 0 35 0 0 +36 G 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -3.511 candidate_22528622 pos=16:17193799-17193839 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 C 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 T 12 14 0 13 0 14 +14 C 13 15 25 14 13 15 +15 A 14 16 24 15 14 16 +16 G 15 17 23 16 15 17 +17 C 16 18 22 17 16 0 +18 A 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 G 20 22 0 21 0 0 +22 G 21 23 17 22 0 23 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32 0 0 +33 C 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -0.912 candidate_22530904 pos=16:58147083-58147123 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 A 9 11 0 10 0 11 +11 C 10 12 21 11 10 12 +12 C 11 13 20 12 11 0 +13 G 12 14 0 13 0 0 +14 T 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 G 19 21 12 20 0 21 +21 G 20 22 11 21 20 22 +22 A 21 23 0 22 21 0 +23 G 22 24 0 23 0 24 +24 G 23 25 32 24 23 25 +25 C 24 26 31 25 24 0 +26 T 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 G 30 32 25 31 0 32 +32 C 31 33 24 32 31 33 +33 T 32 34 0 33 32 0 +34 G 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 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pos=16:91136208-91136248 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 G 10 12 0 11 0 0 +12 A 11 13 0 12 0 13 +13 C 12 14 21 13 12 14 +14 T 13 15 20 14 13 0 +15 A 14 16 0 15 0 0 +16 T 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 G 17 19 0 18 0 0 +19 G 18 20 0 19 0 0 +20 G 19 21 14 20 0 21 +21 G 20 22 13 21 20 22 +22 A 21 23 0 22 21 0 +23 C 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 C 25 27 0 26 0 0 +27 T 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 C 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -2.765 candidate_22535706 pos=16:85174980-85175020 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 A 9 11 0 10 0 11 +11 G 10 12 27 11 10 12 +12 C 11 13 26 12 11 13 +13 A 12 14 25 13 12 14 +14 G 13 15 24 14 13 15 +15 T 14 16 23 15 14 0 +16 T 15 17 0 16 0 0 +17 T 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 T 18 20 0 19 0 0 +20 G 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 A 22 24 15 23 0 24 +24 C 23 25 14 24 23 25 +25 T 24 26 13 25 24 26 +26 G 25 27 12 26 25 27 +27 C 26 28 11 27 26 28 +28 C 27 29 0 28 27 0 +29 C 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 G 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 C 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -0.472 candidate_22536165 pos=16:55102898-55102938 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 6 +6 A 5 7 16 6 5 7 +7 A 6 8 15 7 6 8 +8 C 7 9 14 8 7 9 +9 A 8 10 13 9 8 0 +10 A 9 11 0 10 0 0 +11 G 10 12 0 11 0 0 +12 C 11 13 0 12 0 0 +13 T 12 14 9 13 0 14 +14 G 13 15 8 14 13 15 +15 T 14 16 7 15 14 16 +16 T 15 17 6 16 15 17 +17 C 16 18 0 17 16 0 +18 A 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 T 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 C 25 27 0 26 0 0 +27 T 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 G 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -0.076 candidate_22540553 pos=16:12181858-12181898 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 T 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 G 12 14 0 13 0 0 +14 T 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 T 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 T 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 C 23 25 0 24 0 25 +25 C 24 26 33 25 24 26 +26 A 25 27 32 26 25 0 +27 A 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 T 31 33 26 32 0 33 +33 G 32 34 25 33 32 34 +34 A 33 35 0 34 33 0 +35 C 34 36 0 35 0 0 +36 T 35 37 0 36 0 0 +37 T 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 C 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -0.906 candidate_22540990 pos=16:41118273-41118313 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 T 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 T 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 G 22 24 0 23 0 0 +24 G 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 C 25 27 0 26 0 0 +27 A 26 28 0 27 0 28 +28 C 27 29 35 28 27 29 +29 C 28 30 34 29 28 0 +30 T 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 +34 G 33 35 29 34 0 35 +35 G 34 36 28 35 34 36 +36 A 35 37 0 36 35 0 +37 T 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -2.149 candidate_22542201 pos=16:38187412-38187452 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 T 10 12 0 11 0 0 +12 C 11 13 0 12 0 0 +13 T 12 14 0 13 0 0 +14 A 13 15 0 14 0 15 +15 G 14 16 24 15 14 16 +16 C 15 17 23 16 15 17 +17 C 16 18 22 17 16 0 +18 A 17 19 0 18 0 0 +19 G 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 G 21 23 17 22 0 23 +23 G 22 24 16 23 22 24 +24 C 23 25 15 24 23 25 +25 C 24 26 0 25 24 0 +26 T 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 G 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 G 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -1.842 candidate_22543874 pos=16:63183017-63183057 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 5 +5 C 4 6 15 5 4 6 +6 A 5 7 14 6 5 7 +7 A 6 8 13 7 6 8 +8 C 7 9 12 8 7 0 +9 A 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 T 10 12 0 11 0 0 +12 G 11 13 8 12 0 13 +13 T 12 14 7 13 12 14 +14 T 13 15 6 14 13 15 +15 G 14 16 5 15 14 16 +16 A 15 17 0 16 15 0 +17 A 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 G 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 A 20 22 0 21 0 0 +22 G 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 T 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 T 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 G 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -0.909 candidate_22544870 pos=16:53130099-53130139 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 A 9 11 0 10 0 0 +11 T 10 12 0 11 0 0 +12 T 11 13 0 12 0 0 +13 T 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 A 22 24 0 23 0 24 +24 G 23 25 34 24 23 25 +25 A 24 26 33 25 24 26 +26 C 25 27 32 26 25 0 +27 T 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 G 31 33 26 32 0 33 +33 T 32 34 25 33 32 34 +34 C 33 35 24 34 33 35 +35 C 34 36 0 35 34 0 +36 C 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 G 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -0.136 candidate_22547933 pos=16:27108597-27108637 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 8 +8 C 7 9 15 8 7 9 +9 A 8 10 14 9 8 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 G 12 14 0 13 0 0 +14 T 13 15 9 14 0 15 +15 G 14 16 8 15 14 16 +16 G 15 17 0 16 15 0 +17 G 16 18 0 17 0 0 +18 G 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 G 19 21 0 20 0 0 +21 G 20 22 0 21 0 0 +22 G 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 G 23 25 0 24 0 0 +25 G 24 26 0 25 0 0 +26 G 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 G 28 30 0 29 0 0 +30 G 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 G 35 37 0 36 0 0 +37 G 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = 0.281 candidate_22548148 pos=16:60142430-60142470 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 T 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 G 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 T 17 19 0 18 0 19 +19 C 18 20 27 19 18 20 +20 T 19 21 26 20 19 21 +21 G 20 22 25 21 20 0 +22 T 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 C 24 26 21 25 0 26 +26 A 25 27 20 26 25 27 +27 G 26 28 19 27 26 28 +28 C 27 29 0 28 27 0 +29 A 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 C 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -0.509 candidate_22548235 pos=16:12159703-12159743 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 T 12 14 0 13 0 0 +14 G 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 G 15 17 0 16 0 0 +17 A 16 18 0 17 0 18 +18 C 17 19 29 18 17 19 +19 A 18 20 28 19 18 20 +20 G 19 21 27 20 19 0 +21 A 20 22 0 21 0 0 +22 G 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 G 24 26 0 25 0 0 +26 C 25 27 0 26 0 0 +27 C 26 28 20 27 0 28 +28 T 27 29 19 28 27 29 +29 G 28 30 18 29 28 30 +30 G 29 31 0 30 29 0 +31 A 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 T 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 T 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -0.246 candidate_22548621 pos=16:12161010-12161050 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 C 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 A 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 T 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 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22 24 +24 C 23 25 31 24 23 25 +25 A 24 26 30 25 24 0 +26 T 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 T 29 31 25 30 0 31 +31 G 30 32 24 31 30 32 +32 T 31 33 23 32 31 33 +33 A 32 34 0 33 32 0 +34 C 33 35 0 34 0 0 +35 C 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -3.865 candidate_22551772 pos=16:62190688-62190728 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 8 +8 C 7 9 23 8 7 9 +9 A 8 10 22 9 8 10 +10 C 9 11 21 10 9 11 +11 A 10 12 20 11 10 12 +12 G 11 13 19 12 11 0 +13 T 12 14 0 13 0 0 +14 C 13 15 0 14 0 0 +15 A 14 16 0 15 0 0 +16 G 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 T 17 19 0 18 0 0 +19 C 18 20 12 19 0 20 +20 T 19 21 11 20 19 21 +21 G 20 22 10 21 20 22 +22 T 21 23 9 22 21 23 +23 G 22 24 8 23 22 24 +24 A 23 25 0 24 23 0 +25 C 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 G 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 C 33 35 0 34 0 0 +35 C 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -1.895 candidate_22553460 pos=16:30124149-30124189 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 7 +7 A 6 8 24 7 6 8 +8 C 7 9 23 8 7 9 +9 A 8 10 22 9 8 10 +10 C 9 11 21 10 9 11 +11 A 10 12 20 11 10 0 +12 T 11 13 0 12 0 0 +13 T 12 14 0 13 0 0 +14 T 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 G 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 T 19 21 11 20 0 21 +21 G 20 22 10 21 20 22 +22 T 21 23 9 22 21 23 +23 G 22 24 8 23 22 24 +24 T 23 25 7 24 23 25 +25 C 24 26 0 25 24 0 +26 T 25 27 0 26 0 0 +27 T 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 C 29 31 0 30 0 0 +31 C 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 G 32 34 0 33 0 0 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40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -0.822 candidate_22556001 pos=16:97101262-97101302 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 C 10 12 0 11 0 12 +12 G 11 13 29 12 11 13 +13 T 12 14 28 13 12 14 +14 G 13 15 27 14 13 15 +15 A 14 16 26 15 14 0 +16 C 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 T 18 20 0 19 0 0 +20 C 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 G 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 T 25 27 15 26 0 27 +27 C 26 28 14 27 26 28 +28 A 27 29 13 28 27 29 +29 C 28 30 12 29 28 30 +30 A 29 31 0 30 29 0 +31 T 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 A 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = 0.071 candidate_22556004 pos=16:91190766-91190806 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 C 10 12 0 11 0 12 +12 G 11 13 33 12 11 13 +13 T 12 14 32 13 12 14 +14 G 13 15 31 14 13 0 +15 G 14 16 0 15 0 0 +16 C 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 A 18 20 0 19 0 0 +20 G 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 T 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 G 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 C 30 32 14 31 0 32 +32 A 31 33 13 32 31 33 +33 C 32 34 12 33 32 34 +34 A 33 35 0 34 33 0 +35 C 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 T 38 40 0 39 0 0 +40 C 39 0 0 40 0 0 +40 dG = -1.908 candidate_22556430 pos=16:4139209-4139249 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 11 +11 C 10 12 26 11 10 12 +12 T 11 13 25 12 11 13 +13 G 12 14 24 13 12 14 +14 C 13 15 23 14 13 0 +15 T 14 16 0 15 0 0 +16 C 15 17 0 16 0 0 +17 T 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 G 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 T 21 23 0 22 0 0 +23 G 22 24 14 23 0 24 +24 C 23 25 13 24 23 25 +25 A 24 26 12 25 24 26 +26 G 25 27 11 26 25 27 +27 C 26 28 0 27 26 0 +28 A 27 29 0 28 0 0 +29 A 28 30 0 29 0 30 +30 C 29 31 38 30 29 31 +31 A 30 32 37 31 30 0 +32 C 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 A 34 36 0 35 0 0 +36 C 35 37 0 36 0 0 +37 T 36 38 31 37 0 38 +38 G 37 39 30 38 37 39 +39 A 38 40 0 39 38 0 +40 A 39 0 0 40 0 0 +40 dG = -4.601 candidate_22557039 pos=16:7141448-7141488 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 8 +8 C 7 9 21 8 7 9 +9 A 8 10 20 9 8 10 +10 C 9 11 19 10 9 11 +11 G 10 12 18 11 10 0 +12 C 11 13 0 12 0 0 +13 G 12 14 0 13 0 0 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18 0 0 +19 C 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 C 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 T 22 24 0 23 0 0 +24 C 23 25 0 24 0 0 +25 A 24 26 0 25 0 0 +26 C 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 A 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 G 30 32 0 31 0 0 +32 T 31 33 13 32 0 33 +33 C 32 34 12 33 32 34 +34 A 33 35 11 34 33 35 +35 G 34 36 10 35 34 36 +36 A 35 37 0 36 35 0 +37 A 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -1.808 candidate_22559612 pos=16:77145310-77145350 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 10 +10 C 9 11 26 10 9 11 +11 T 10 12 25 11 10 12 +12 G 11 13 24 12 11 13 +13 A 12 14 23 13 12 14 +14 G 13 15 22 14 13 15 +15 A 14 16 21 15 14 0 +16 T 15 17 0 16 0 0 +17 T 16 18 0 17 0 0 +18 C 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 T 20 22 15 21 0 22 +22 C 21 23 14 22 21 23 +23 T 22 24 13 23 22 24 +24 T 23 25 12 24 23 25 +25 A 24 26 11 25 24 26 +26 G 25 27 10 26 25 27 +27 A 26 28 0 27 26 0 +28 C 27 29 0 28 0 0 +29 C 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 G 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 A 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 T 37 39 0 38 0 0 +39 G 38 40 0 39 0 0 +40 G 39 0 0 40 0 0 +40 dG = -1.825 candidate_22560242 pos=16:37102570-37102610 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 T 10 12 0 11 0 0 +12 G 11 13 0 12 0 0 +13 G 12 14 0 13 0 0 +14 G 13 15 0 14 0 0 +15 G 14 16 0 15 0 0 +16 A 15 17 0 16 0 0 +17 A 16 18 0 17 0 0 +18 A 17 19 0 18 0 19 +19 A 18 20 39 19 18 20 +20 G 19 21 38 20 19 21 +21 A 20 22 37 21 20 22 +22 G 21 23 36 22 21 23 +23 T 22 24 35 23 22 0 +24 C 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 C 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 T 27 29 0 28 0 0 +29 T 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 T 30 32 0 31 0 0 +32 T 31 33 0 32 0 0 +33 A 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 A 34 36 23 35 0 36 +36 C 35 37 22 36 35 37 +37 T 36 38 21 37 36 38 +38 C 37 39 20 38 37 39 +39 T 38 40 19 39 38 40 +40 G 39 0 0 40 39 0 +40 dG = -0.149 candidate_22560764 pos=16:57137711-57137751 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 C 9 11 0 10 0 0 +11 T 10 12 0 11 0 0 +12 T 11 13 0 12 0 13 +13 A 12 14 35 13 12 14 +14 G 13 15 34 14 13 15 +15 C 14 16 33 15 14 0 +16 A 15 17 0 16 0 0 +17 G 16 18 0 17 0 0 +18 G 17 19 0 18 0 0 +19 T 18 20 0 19 0 0 +20 T 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 C 21 23 0 22 0 0 +23 A 22 24 0 23 0 0 +24 T 23 25 0 24 0 0 +25 T 24 26 0 25 0 0 +26 G 25 27 0 26 0 0 +27 A 26 28 0 27 0 0 +28 C 27 29 0 28 0 0 +29 A 28 30 0 29 0 0 +30 T 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 G 32 34 15 33 0 34 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T 38 40 0 39 0 0 +40 T 39 0 0 40 0 0 +40 dG = -0.709 candidate_22563296 pos=16:87145435-87145475 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 G 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 G 13 15 0 14 0 0 +15 C 14 16 0 15 0 16 +16 C 15 17 29 16 15 17 +17 C 16 18 28 17 16 18 +18 A 17 19 27 18 17 0 +19 C 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 A 25 27 0 26 0 0 +27 T 26 28 18 27 0 28 +28 G 27 29 17 28 27 29 +29 G 28 30 16 29 28 30 +30 A 29 31 0 30 29 0 +31 A 30 32 0 31 0 0 +32 G 31 33 0 32 0 0 +33 C 32 34 0 33 0 0 +34 T 33 35 0 34 0 0 +35 G 34 36 0 35 0 0 +36 A 35 37 0 36 0 0 +37 C 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 +40 dG = -0.736 candidate_22563325 pos=16:15143614-15143654 +1 A 0 2 0 1 0 0 +2 A 1 3 0 2 0 0 +3 A 2 4 0 3 0 0 +4 A 3 5 0 4 0 0 +5 C 4 6 0 5 0 0 +6 A 5 7 0 6 0 0 +7 A 6 8 0 7 0 0 +8 C 7 9 0 8 0 0 +9 A 8 10 0 9 0 0 +10 G 9 11 0 10 0 0 +11 A 10 12 0 11 0 0 +12 A 11 13 0 12 0 0 +13 A 12 14 0 13 0 0 +14 G 13 15 0 14 0 0 +15 C 14 16 0 15 0 0 +16 C 15 17 0 16 0 0 +17 C 16 18 0 17 0 0 +18 A 17 19 0 18 0 0 +19 C 18 20 0 19 0 0 +20 A 19 21 0 20 0 0 +21 T 20 22 0 21 0 0 +22 A 21 23 0 22 0 0 +23 C 22 24 0 23 0 0 +24 A 23 25 0 24 0 0 +25 C 24 26 0 25 0 0 +26 G 25 27 0 26 0 27 +27 A 26 28 34 27 26 28 +28 G 27 29 33 28 27 0 +29 G 28 30 0 29 0 0 +30 A 29 31 0 30 0 0 +31 A 30 32 0 31 0 0 +32 A 31 33 0 32 0 0 +33 C 32 34 28 33 0 34 +34 T 33 35 27 34 33 35 +35 G 34 36 0 35 34 0 +36 A 35 37 0 36 0 0 +37 A 36 38 0 37 0 0 +38 C 37 39 0 38 0 0 +39 A 38 40 0 39 0 0 +40 A 39 0 0 40 0 0 diff --git a/test_data/test.tm.tsv b/test_data/test.tm.tsv new file mode 100644 index 00000000..d47c72fb --- /dev/null +++ b/test_data/test.tm.tsv @@ -0,0 +1,501 @@ +name dG dH dS Tm Seq +candidate_21654043 pos=16:11114621-11114661 -49.122 -315.200 -0.858 41.45 AAAACAAAACAAAACAAAACACTGCCCTCATCTCAAGTCC +candidate_21658299 pos=16:22131287-22131327 -51.750 -317.300 -0.856 44.64 AAAACAAAACAAAACAAAACCCCAGCCAACCAAGCCTCAC +candidate_21666318 pos=16:31196747-31196787 -48.067 -314.300 -0.858 40.17 AAAACAAAACAAAACAAACAAAAGTATCACCCTATCGCCC +candidate_21670946 pos=16:68188874-68188914 -48.443 -314.800 -0.859 40.56 AAAACAAAACAAAACAAACCGAAAGTACCTGGACATACGA +candidate_21676743 pos=16:90188443-90188483 -48.544 -316.700 -0.865 40.40 AAAACAAAACAAAACAACAACAACAAACTCAGCTAGCTCC +candidate_21685155 pos=16:14129896-14129936 -50.907 -315.000 -0.851 43.94 AAAACAAAACAAAACACCATGAGGCCTTAGGCATGGGTTC +candidate_21686495 pos=16:11114626-11114666 -50.251 -312.700 -0.846 43.38 AAAACAAAACAAAACACTGCCCTCATCTCAAGTCCCCAAA +candidate_21686514 pos=16:81179833-81179873 -48.401 -314.200 -0.857 40.70 AAAACAAAACAAAACACTGGAAGCTTCTAAGTGACAGAGG +candidate_21686674 pos=16:9163163-9163203 -48.627 -311.200 -0.847 41.45 AAAACAAAACAAAACACTTGAGGCAGGGAGATAGCTTAGT +candidate_21687718 pos=16:70191486-70191526 -50.708 -316.600 -0.857 43.33 AAAACAAAACAAAACAGAACCGCACAGTGGAGGAGCAATA +candidate_21696099 pos=16:22131292-22131332 -54.428 -318.800 -0.852 48.11 AAAACAAAACAAAACCCCAGCCAACCAAGCCTCACAGCCC +candidate_21696605 pos=16:76195412-76195452 -47.304 -311.800 -0.853 39.59 AAAACAAAACAAAACCCTCTAAGCTTCTGTTCTTTTCCTC +candidate_21696680 pos=16:23161159-23161199 -49.127 -311.700 -0.847 42.01 AAAACAAAACAAAACCCTGATCTTGAAAGCCAAGAGGTGA +candidate_21696763 pos=16:33141995-33142035 -50.129 -316.300 -0.858 42.65 AAAACAAAACAAAACCCTGTTGGTTTTCCGACTTAGCAGG +candidate_21696985 pos=16:15154698-15154738 -48.294 -313.100 -0.854 40.64 AAAACAAAACAAAACCGTGTTGTAGATGTTCCTGGAGAAA +candidate_21698710 pos=16:73144761-73144801 -48.000 -311.100 -0.848 40.57 AAAACAAAACAAAACGGCAAATCCTAACTATGGAGTGGAT +candidate_21699937 pos=16:90136408-90136448 -48.912 -315.300 -0.859 41.17 AAAACAAAACAAAACTCAATTAGCCACAGAGCACCAAGAG +candidate_21700882 pos=16:43126383-43126423 -52.311 -321.800 -0.869 44.60 AAAACAAAACAAAACTGCTTAACACCTTGCCAGGCGCATG +candidate_21704015 pos=16:47181492-47181532 -49.655 -312.600 -0.848 42.64 AAAACAAAACAAAAGAGGGCTCTGAGGTCAGTTGCTATGA +candidate_21712832 pos=16:20146964-20147004 -48.718 -313.400 -0.853 41.12 AAAACAAAACAAAATTGTAAGTTGGAGGCAAGAGCTGTGT +candidate_21717478 pos=16:31196752-31196792 -48.499 -310.700 -0.845 41.36 AAAACAAAACAAACAAAAGTATCACCCTATCGCCCTAGGT +candidate_21732049 pos=16:68188879-68188919 -49.084 -314.200 -0.855 41.56 AAAACAAAACAAACCGAAAGTACCTGGACATACGAACCTT +candidate_21732995 pos=16:48174889-48174929 -49.933 -316.600 -0.860 42.35 AAAACAAAACAAACTCAAGATTCTGCTTGAGTGACAGGGC +candidate_21734070 pos=16:6153316-6153356 -47.031 -311.000 -0.851 39.36 AAAACAAAACAAAGAAACTCCATCTTTGGGTCTAGTCATG +candidate_21734516 pos=16:85140354-85140394 -46.619 -307.300 -0.841 39.39 AAAACAAAACAAAGAAGAAGGATAGAAGGAACCAGAGAGA +candidate_21735207 pos=16:5178254-5178294 -53.045 -317.200 -0.852 46.51 AAAACAAAACAAAGAGCTAGGCACTCGGGAGGTTGAGGCA +candidate_21738820 pos=16:11141085-11141125 -49.060 -314.300 -0.855 41.61 AAAACAAAACAAAGGCTAGAGAGATGGCTCAGCAGTTAAG +candidate_21748103 pos=16:45181671-45181711 -48.588 -315.100 -0.859 40.70 AAAACAAAACAACAACAAAACCCACACAATGGATGTGATG +candidate_21749831 pos=16:90188448-90188488 -48.297 -312.700 -0.852 40.70 AAAACAAAACAACAACAACAAACTCAGCTAGCTCCCATTA +candidate_21753987 pos=16:27162495-27162535 -51.542 -321.900 -0.872 43.63 AAAACAAAACAACAGAAAGCTCACATACACGTGGAAGCCG +candidate_21755149 pos=16:30168215-30168255 -49.435 -313.000 -0.850 42.19 AAAACAAAACAACCAAACAACAAGGTGTCTCTTTGCCCTA +candidate_21756048 pos=16:16119405-16119445 -49.347 -310.400 -0.842 42.60 AAAACAAAACAACCCAACCATGAACATAGACTCAGACCCT +candidate_21758248 pos=16:33187988-33188028 -50.598 -316.800 -0.858 43.26 AAAACAAAACAACTCGTGGTCTCCTTTTCTTGGCTTCTCC +candidate_21759100 pos=16:36139573-36139613 -49.428 -313.800 -0.852 42.16 AAAACAAAACAAGAAAACCCCATGCTTCAGATAGCTAGGC +candidate_21759804 pos=16:50168025-50168065 -49.120 -316.500 -0.862 41.25 AAAACAAAACAAGAACAACTTCCTGCACATCTTTGCTCTC +candidate_21761043 pos=16:9183788-9183828 -50.067 -315.400 -0.855 42.81 AAAACAAAACAAGACAAGACAAGACAGGACAGGACAGGAC +candidate_21774421 pos=16:82180535-82180575 -50.660 -311.000 -0.839 44.39 AAAACAAAACACAGACTCTCCCTCTCCCAGTAGCCATCAT +candidate_21775575 pos=16:4115534-4115574 -53.055 -316.900 -0.851 46.58 AAAACAAAACACATTCCCAGGCTGGATTTGGCTCTTGGCC +candidate_21777113 pos=16:14129901-14129941 -52.438 -315.600 -0.848 46.01 AAAACAAAACACCATGAGGCCTTAGGCATGGGTTCACTGG +candidate_21778714 pos=16:50167929-50167969 -50.398 -310.800 -0.840 44.09 AAAACAAAACACCTCCCTAGGGCTAGTGCTCTAGCTAAGT +candidate_21778745 pos=16:85151414-85151454 -50.986 -313.900 -0.848 44.43 AAAACAAAACACCTCTCCTAGACCAGAGACTAGGTGGTGC +candidate_21779002 pos=16:16185138-16185178 -49.676 -312.900 -0.849 42.72 AAAACAAAACACCTTCCTCTCAACACCTCATGGTACCTTC +candidate_21780635 pos=16:11114631-11114671 -50.961 -313.100 -0.845 44.33 AAAACAAAACACTGCCCTCATCTCAAGTCCCCAAACAACT +candidate_21780699 pos=16:81179838-81179878 -48.079 -310.900 -0.847 40.80 AAAACAAAACACTGGAAGCTTCTAAGTGACAGAGGATACA +candidate_21781230 pos=16:9163168-9163208 -49.019 -310.600 -0.843 42.14 AAAACAAAACACTTGAGGCAGGGAGATAGCTTAGTTGGTA +candidate_21784795 pos=16:70191491-70191531 -51.380 -316.000 -0.853 44.38 AAAACAAAACAGAACCGCACAGTGGAGGAGCAATACCATT +candidate_21785278 pos=16:96178155-96178195 -51.296 -313.900 -0.847 44.62 AAAACAAAACAGAAGGCCACAAGGAAAAGGCTAACAGCCT +candidate_21785540 pos=16:88192867-88192907 -49.954 -312.000 -0.845 43.22 AAAACAAAACAGAATAGCAGTTAGGCGGTAGGAGGGAGAA +candidate_21790463 pos=16:73187251-73187291 -50.159 -313.600 -0.849 43.22 AAAACAAAACAGGAAGGGAATGACTGGAGCCATTCAAGAC +candidate_21791592 pos=16:61181111-61181151 -51.861 -313.100 -0.842 45.69 AAAACAAAACAGGGAGGAGATGCCTTGGGTCCTGGAAATG +candidate_21792153 pos=16:20134652-20134692 -48.028 -311.500 -0.849 40.74 AAAACAAAACAGGTCCTTAGAGGCAAGAACTACTGTAGAG +candidate_21792914 pos=16:22154266-22154306 -48.255 -312.100 -0.851 40.74 AAAACAAAACAGTATAAGTAGCAGCCAAACAAAACCACCA +candidate_21793507 pos=16:11160012-11160052 -53.130 -321.100 -0.864 45.85 AAAACAAAACAGTGCCAGTGCACTGGTGCACGACTTTAGT +candidate_21795805 pos=16:14150563-14150603 -46.432 -311.300 -0.854 38.57 AAAACAAAACATACAATCTAAGTGAGTCCAAGTCTCTGAC +candidate_21797204 pos=16:6123369-6123409 -50.290 -314.600 -0.852 43.22 AAAACAAAACATCACAGAACCTGGCAGATGGCTTCCTATG +candidate_21798346 pos=16:83195310-83195350 -47.523 -309.600 -0.845 40.29 AAAACAAAACATGAAATATGGTGACCAGAGTAAAGGGGAG +candidate_21806808 pos=16:36186937-36186977 -49.125 -313.900 -0.854 41.66 AAAACAAAACCAAACAAAACCAACAGAAATCCACTGGGTC +candidate_21808115 pos=16:44115256-44115296 -46.825 -306.700 -0.838 39.75 AAAACAAAACCAAACCCTATACATAGCCAGATGGTATGAA +candidate_21808347 pos=16:39121119-39121159 -50.310 -318.900 -0.866 42.47 AAAACAAAACCAAACTTCCAGCTGTTCAAGTCGTCTTGTG +candidate_21814235 pos=16:91158849-91158889 -50.061 -311.300 -0.842 43.47 AAAACAAAACCACTGACTCACCAAGATAGACTTGGGTGGA +candidate_21814624 pos=16:18106422-18106462 -49.213 -311.600 -0.846 42.13 AAAACAAAACCAGAAAGAAGCCACATAGAATGTTGGGCAT +candidate_21815172 pos=16:53106595-53106635 -46.565 -309.200 -0.847 39.04 AAAACAAAACCAGAGATTATTCAGTTGTCTAATGGGAACC +candidate_21815808 pos=16:22192173-22192213 -49.370 -314.300 -0.854 42.01 AAAACAAAACCAGGACAGTGTGTTACCTCCAAACATTAGC +candidate_21817435 pos=16:6147636-6147676 -52.331 -315.400 -0.848 45.80 AAAACAAAACCATGCAGCGGATGGATTCTGGGGAATGACA +candidate_21822694 pos=16:22131297-22131337 -54.330 -315.600 -0.842 48.56 AAAACAAAACCCCAGCCAACCAAGCCTCACAGCCCTCTTT +candidate_21822783 pos=16:41170402-41170442 -47.697 -307.200 -0.837 40.79 AAAACAAAACCCCATAGGTTTAAATAGCATTGTTGGGGTT +candidate_21823349 pos=16:97153091-97153131 -50.849 -309.700 -0.835 44.86 AAAACAAAACCCCTAAGACTCCCCAGCTGTGCCCATATTA +candidate_21823586 pos=16:6111442-6111482 -52.531 -315.600 -0.848 46.13 AAAACAAAACCCCTTAAATTGGAGTGCACCCCTTCACGGG +candidate_21824607 pos=16:76195417-76195457 -49.143 -309.700 -0.840 42.45 AAAACAAAACCCTCTAAGCTTCTGTTCTTTTCCTCCTGGT +candidate_21824874 pos=16:23161164-23161204 -49.661 -310.900 -0.842 42.92 AAAACAAAACCCTGATCTTGAAAGCCAAGAGGTGATTGGA +candidate_21825189 pos=16:33142000-33142040 -50.941 -314.600 -0.850 44.05 AAAACAAAACCCTGTTGGTTTTCCGACTTAGCAGGAGTCA +candidate_21826337 pos=16:15154703-15154743 -47.841 -311.500 -0.850 40.31 AAAACAAAACCGTGTTGTAGATGTTCCTGGAGAAAGAAAT +candidate_21829358 pos=16:38192572-38192612 -48.132 -313.000 -0.854 40.55 AAAACAAAACCTGGCTAATTTAGTACAGTGCTTTGTCCTC +candidate_21833371 pos=16:69120689-69120729 -47.458 -310.000 -0.846 40.15 AAAACAAAACGATGTAGTGTATCTCAGGGTAGACATGGTA +candidate_21834136 pos=16:90170058-90170098 -49.874 -315.300 -0.856 42.48 AAAACAAAACGGAGGAATAAATAGCCGCTGTCTCATAGCA +candidate_21834208 pos=16:73144766-73144806 -48.502 -310.300 -0.844 41.43 AAAACAAAACGGCAAATCCTAACTATGGAGTGGATCCTTT +candidate_21834785 pos=16:27141570-27141610 -48.304 -311.900 -0.850 40.93 AAAACAAAACGTATGAACCCAGAATGAGTAGACAACAGGA +candidate_21838028 pos=16:4109470-4109510 -46.991 -306.400 -0.836 40.00 AAAACAAAACTAATCCCCAACTCTCTTTCCCTGATCAAAT +candidate_21838265 pos=16:70179074-70179114 -48.253 -313.400 -0.855 40.54 AAAACAAAACTACAAAATCATGCCGAGGAAAGACAGTGAA +candidate_21838416 pos=16:31102444-31102484 -46.726 -313.300 -0.859 38.65 AAAACAAAACTACACAACACGGAAGATATTCTCTGTAGTG +candidate_21839431 pos=16:24135799-24135839 -50.795 -311.600 -0.841 44.46 AAAACAAAACTAGAGGTTCACTGGGAGGACTAGCCAAGCT +candidate_21841895 pos=16:90136413-90136453 -50.463 -316.200 -0.857 43.19 AAAACAAAACTCAATTAGCCACAGAGCACCAAGAGGACAC +candidate_21842556 pos=16:68125708-68125748 -48.508 -313.500 -0.854 40.84 AAAACAAAACTCATCACAATTGTAAGCAGCCACTTGAGTT +candidate_21842776 pos=16:14112129-14112169 -50.532 -315.400 -0.854 43.30 AAAACAAAACTCCAAACCCAAACAACCAAAGCACCAAAGG +candidate_21844822 pos=16:40101009-40101049 -48.032 -312.900 -0.854 40.34 AAAACAAAACTCTTGTGACAACACACATGAAGTATCCACA +candidate_21846752 pos=16:94180536-94180576 -51.883 -316.100 -0.852 45.21 AAAACAAAACTGCATGTCATCCAGAGGCCAGAGAGCCTAG +candidate_21847087 pos=16:43126388-43126428 -53.513 -320.800 -0.862 46.49 AAAACAAAACTGCTTAACACCTTGCCAGGCGCATGGATCC +candidate_21848800 pos=16:84137050-84137090 -48.489 -311.000 -0.846 41.30 AAAACAAAACTGTGATGTATAGTTGTGAAAGGGGACAGCT +candidate_21849939 pos=16:90133192-90133232 -47.614 -310.900 -0.849 40.21 AAAACAAAACTTACCATAGCTAGAGTGATTCACAAACCCC +candidate_21851787 pos=16:14185388-14185428 -47.448 -310.300 -0.848 39.99 AAAACAAAACTTGGTTATGTGTTCCAGACAGAAGAGAACT +candidate_21852077 pos=16:32162767-32162807 -49.985 -312.000 -0.845 43.26 AAAACAAAACTTTAAAAGGGTGGGAGGCAGAAGAGAACCC +candidate_21852860 pos=16:63108540-63108580 -47.570 -312.500 -0.854 39.82 AAAACAAAACTTTGGTGGCTGGTAATGTAGATCAATGTTG +candidate_21856056 pos=16:17181427-17181467 -47.479 -310.300 -0.847 40.03 AAAACAAAAGAAAACACAGAAGTAGCCCATCTCTTTGAGA +candidate_21858474 pos=16:22172199-22172239 -48.764 -310.500 -0.844 41.73 AAAACAAAAGAAACTGGAGGATGATGGAGCAATGCCTTTA +candidate_21858525 pos=16:29165094-29165134 -48.441 -312.100 -0.850 40.97 AAAACAAAAGAAACTTTCAATGCAAGCCAGATGACCTGAT +candidate_21859959 pos=16:50118068-50118108 -49.379 -312.200 -0.847 42.35 AAAACAAAAGAAATATCCAGTGGCCAAAACCAGAACCAGG +candidate_21863612 pos=16:17180243-17180283 -48.405 -313.800 -0.856 40.77 AAAACAAAAGAAGTGAAGGCAGATCTTTGTGAGTTGAAGG +candidate_21864202 pos=16:84196585-84196625 -46.787 -311.500 -0.854 38.98 AAAACAAAAGAATACACTGTCTTCTCAGTACCAAAAGGTG +candidate_21864435 pos=16:8132196-8132236 -47.016 -308.100 -0.842 39.78 AAAACAAAAGAATATAACTTCTCAGCACCTCATGGAACCT +candidate_21866061 pos=16:42197679-42197719 -47.648 -310.500 -0.848 40.22 AAAACAAAAGAATGGAGAGACTGCAAACATACTCCACTTT +candidate_21866445 pos=16:80127300-80127340 -47.432 -306.500 -0.835 40.55 AAAACAAAAGAATTCCATTCCTAATCATTCCCCAAAGGCT +candidate_21868748 pos=16:96107225-96107265 -50.720 -313.200 -0.846 44.10 AAAACAAAAGACCAGGGATGGTGGCATAGCTCAGTAAAGG +candidate_21868751 pos=16:44165904-44165944 -48.394 -313.200 -0.854 40.85 AAAACAAAAGACCAGGTGACCAGCAATGTGATTAGAAAAG +candidate_21871569 pos=16:24108671-24108711 -49.132 -314.000 -0.854 41.75 AAAACAAAAGAGCACTCCTTGCTCAGGTATTTACCTGTTG +candidate_21872058 pos=16:17195497-17195537 -50.719 -316.300 -0.856 43.49 AAAACAAAAGAGGAAGAAAGGAAGCCAGCAAGCAAGTCAG +candidate_21872220 pos=16:14180132-14180172 -48.273 -307.900 -0.837 41.62 AAAACAAAAGAGGATAGTGGAAGAGTGTAGGGGACAGAAA +candidate_21872467 pos=16:47181497-47181537 -49.344 -311.700 -0.846 42.38 AAAACAAAAGAGGGCTCTGAGGTCAGTTGCTATGAAAAGA +candidate_21872626 pos=16:43122088-43122128 -50.360 -316.500 -0.858 43.01 AAAACAAAAGAGGTGAAAAGAAGTCTGCAGTCTAGCTGCC +candidate_21874668 pos=16:6176861-6176901 -52.078 -308.200 -0.826 46.94 AAAACAAAAGATCTGCTAACATCCTCCCCTCCCCTCCCCT +candidate_21875152 pos=16:18106130-18106170 -51.803 -309.600 -0.831 46.43 AAAACAAAAGATGGAGGAGGAGGAGGAGGAGGAGGAGGAG +candidate_21875178 pos=16:44178494-44178534 -50.268 -312.500 -0.845 43.54 AAAACAAAAGATGGCATCCCGTGACAGGTACCAGTTCTAT +candidate_21875790 pos=16:78106632-78106672 -50.648 -313.500 -0.848 43.76 AAAACAAAAGATTCCAAAATAGGCCAAGCAGGTGCAACCA +candidate_21875941 pos=16:66143845-66143885 -47.461 -308.700 -0.842 40.25 AAAACAAAAGATTGGAAATCCACAGTAATCCATGCCAGTA +candidate_21875958 pos=16:43193506-43193546 -51.663 -316.500 -0.854 44.76 AAAACAAAAGATTGGGCTGCACTGTGTTCCTGTAAGTGGG +candidate_21877901 pos=16:35139947-35139987 -49.520 -317.800 -0.865 41.45 AAAACAAAAGCAAAAGCAAAGCACGATGCTAATGTGAGAA +candidate_21880075 pos=16:92131398-92131438 -49.454 -316.400 -0.861 41.68 AAAACAAAAGCAAGCAAACAACATCATCACCATCATCACC +candidate_21880288 pos=16:68164199-68164239 -50.442 -315.000 -0.853 43.25 AAAACAAAAGCAAGGCTGTTGAACACCTAAGCCAACAGTA +candidate_21881395 pos=16:39190074-39190114 -50.151 -311.700 -0.843 43.52 AAAACAAAAGCACTCTAAGCAGCTTAGGGAGGAAAGGAGT +candidate_21882598 pos=16:20162935-20162975 -48.199 -309.500 -0.842 41.17 AAAACAAAAGCATAAAACCTCAGTCCTGTCATAGCCCATA +candidate_21883244 pos=16:96178942-96178982 -49.249 -313.900 -0.853 41.71 AAAACAAAAGCATGCTTTGGCTTATGGTTGTTGGCATTAA +candidate_21883970 pos=16:33164535-33164575 -51.111 -310.800 -0.837 45.01 AAAACAAAAGCCAACCTAAGGGTTGGAGAGATGGTCCAGT +candidate_21884557 pos=16:65100610-65100650 -52.234 -314.900 -0.847 45.86 AAAACAAAAGCCAGCCCTGTTTCCCTGATCCTCAGTTTCC +candidate_21884633 pos=16:5196409-5196449 -51.815 -317.800 -0.858 44.74 AAAACAAAAGCCAGGCATGATGGTACGTTGGAAGTTGGAG +candidate_21884867 pos=16:73131946-73131986 -47.059 -311.400 -0.852 39.34 AAAACAAAAGCCATCGTCTTAAGGGTATTATGTGGAAATG +candidate_21885172 pos=16:29179333-29179373 -49.264 -310.100 -0.841 42.54 AAAACAAAAGCCCACCTAGACCATCATCTACCATTTGTGT +candidate_21887125 pos=16:51197616-51197656 -50.437 -317.600 -0.861 42.93 AAAACAAAAGCTACATGGCCGATGCTCTCTTCACATGTAG +candidate_21888142 pos=16:57184506-57184546 -49.300 -312.400 -0.848 42.22 AAAACAAAAGCTGCAATAGGAGACTCTCTGCCAAGACTAA +candidate_21888583 pos=16:8147690-8147730 -53.712 -319.200 -0.856 47.02 AAAACAAAAGCTGTGTGACATACTGTGGCCCACTGCAGCT +candidate_21890845 pos=16:61173693-61173733 -48.283 -311.600 -0.849 40.85 AAAACAAAAGGAAGAAACACAAAACCTGTGGAGTTCATGT +candidate_21890879 pos=16:12137774-12137814 -46.741 -309.500 -0.847 39.32 AAAACAAAAGGAAGAAGATTGATAGTGAGAGAGGAGTCTG +candidate_21891758 pos=16:90196260-90196300 -49.661 -310.900 -0.842 42.92 AAAACAAAAGGACAAAGATTGACAGCATCCAAGGAGGGAA +candidate_21892971 pos=16:25169626-25169666 -46.340 -308.200 -0.844 38.91 AAAACAAAAGGAGGAGGAAGAGAATTAAGAAATTGACAGG +candidate_21893541 pos=16:96106024-96106064 -49.897 -308.500 -0.834 43.72 AAAACAAAAGGATACTTATGGGCTGGGGAGATGGCTCATT +candidate_21894666 pos=16:19131189-19131229 -47.097 -306.600 -0.837 40.21 AAAACAAAAGGATATACCTTCTTCTCAGCACCTCATCCTA +candidate_21896771 pos=16:4154836-4154876 -49.881 -315.400 -0.856 42.48 AAAACAAAAGGCAACTTACCATATTTGGCACAGTGGTGAC +candidate_21897548 pos=16:91199660-91199700 -51.291 -311.600 -0.839 45.11 AAAACAAAAGGCCACTCTCTCCCCTTCTCCAGCTTCTTTT +candidate_21898022 pos=16:5142581-5142621 -49.116 -311.100 -0.845 42.19 AAAACAAAAGGCTAGCCTTGGATGTATAGCAAGACTGTCT +candidate_21902275 pos=16:97126580-97126620 -48.437 -309.800 -0.843 41.43 AAAACAAAAGGTTTTACTATTGTTCACGGGGATGGATGGA +candidate_21904481 pos=16:51138374-51138414 -47.156 -311.900 -0.854 39.39 AAAACAAAAGTAGGAAAGCATTTCATTGTGGAAGCTCTAG +candidate_21904608 pos=16:11192920-11192960 -47.196 -309.800 -0.847 39.75 AAAACAAAAGTAGTCAGGTGAGATGTGAAATACCAACAGT +candidate_21909049 pos=16:17189854-17189894 -48.031 -311.100 -0.848 40.61 AAAACAAAAGTGGTGAGGAAAGATGGCTCAACAGTTAAAA +candidate_21909100 pos=16:22147477-22147517 -50.074 -315.500 -0.856 42.70 AAAACAAAAGTGTAAAGTGCTTGCCAGACACAGAGACTCA +candidate_21911224 pos=16:21183507-21183547 -47.082 -309.500 -0.846 39.65 AAAACAAAAGTTGGTACCAGAAGTAGAGTATTGCTGTGAT +candidate_21915805 pos=16:6147626-6147666 -48.485 -315.400 -0.861 40.53 AAAACAAAATAAAACAAAACCATGCAGCGGATGGATTCTG +candidate_21920282 pos=16:32187546-32187586 -48.636 -314.900 -0.859 40.79 AAAACAAAATAAACAGAAAAGCAAGCATTCCACAAAGCCC +candidate_21924434 pos=16:72152772-72152812 -48.419 -310.000 -0.843 41.37 AAAACAAAATAACCAGTACTTGTGACTTCCTGGCTTCCAT +candidate_21925638 pos=16:24143294-24143334 -47.190 -310.600 -0.849 39.62 AAAACAAAATAAGATGGTGGTTTGCCTTAATGACAGGAAG +candidate_21939090 pos=16:28155420-28155460 -51.290 -314.700 -0.849 44.48 AAAACAAAATATGCTCAGTGCAAACCTCAAGGGCAGGTCA +candidate_21943614 pos=16:78146038-78146078 -49.516 -310.600 -0.842 42.78 AAAACAAAATCAAGACTACAGCAGGAAAATGGGTGGAGGT +candidate_21945865 pos=16:28149023-28149063 -47.586 -311.400 -0.851 40.00 AAAACAAAATCAGGGGTGCTTTAATATCATGGTTGCAATC +candidate_21951625 pos=16:91185437-91185477 -47.285 -308.400 -0.842 40.07 AAAACAAAATCTCAACCAAATCCTAGCCTACTGCCTTTTA +candidate_21951703 pos=16:54143955-54143995 -49.143 -314.600 -0.856 41.67 AAAACAAAATCTCACAGCAAACCTGTCCTTCTCTTCTGAC +candidate_21951872 pos=16:10129152-10129192 -52.718 -317.400 -0.853 46.06 AAAACAAAATCTCATGCAACCAAGTCAGGCCTCCAGCTGG +candidate_21955055 pos=16:28167909-28167949 -47.319 -312.900 -0.856 39.44 AAAACAAAATGAAACAAAACTCCGGTATCTTTCCTGTCTC +candidate_21956780 pos=16:91182411-91182451 -51.419 -317.900 -0.859 44.02 AAAACAAAATGAAGCCAGCTTTGAACACACTGTGTTGGCA +candidate_21958297 pos=16:50115922-50115962 -50.817 -314.600 -0.850 43.89 AAAACAAAATGAGAAAGGCGTGGTTGAGCTAGCCTCCATA +candidate_21959123 pos=16:17100947-17100987 -48.037 -310.300 -0.846 40.84 AAAACAAAATGAGTGTGTCTAACACTAGTAGAAAGCCCCA +candidate_21961679 pos=16:83169237-83169277 -48.151 -309.700 -0.843 41.08 AAAACAAAATGCCTTCTATCCACCTTCAGAAGACTTCAGT +candidate_21961983 pos=16:80154036-80154076 -48.704 -312.300 -0.850 41.37 AAAACAAAATGCTCACAGAGGTGAAGGTGATCTACACAAA +candidate_21966751 pos=16:37129884-37129924 -50.716 -318.500 -0.863 43.14 AAAACAAAATGTCCGTGCTATTCTCATGTCTGTCAGTGGC +candidate_21967395 pos=16:58168778-58168818 -47.893 -310.900 -0.848 40.46 AAAACAAAATGTGCCTTAGCACAGTGGGCAATTTAGTATA +candidate_21968283 pos=16:18109528-18109568 -51.638 -314.800 -0.848 45.01 AAAACAAAATGTTCCTCTGGTTTTCCAACAGGCTGTGGGG +candidate_21972372 pos=16:48194702-48194742 -47.430 -308.700 -0.842 40.21 AAAACAAAATTAGAGACAAGGACATGAGGTAAAATGGCCA +candidate_21973007 pos=16:47167787-47167827 -48.337 -309.700 -0.843 41.31 AAAACAAAATTATAACACTGGGTCCTTATCCTGTGCTGCT +candidate_21978114 pos=16:63152879-63152919 -48.990 -313.300 -0.852 41.68 AAAACAAAATTGAGGGACTCCAGAATACAGAAAGAGCTGC +candidate_21979257 pos=16:20146969-20147009 -48.297 -312.700 -0.853 40.70 AAAACAAAATTGTAAGTTGGAGGCAAGAGCTGTGTTGTAA +candidate_21979283 pos=16:75142524-75142564 -48.205 -313.600 -0.856 40.55 AAAACAAAATTGTACAGAAAGGAACTACTCAGAGCCATGC +candidate_21982381 pos=16:41132040-41132080 -49.271 -311.100 -0.844 42.39 AAAACAAAATTTCTACCCACTACTCCCTGCAGTGACAGTT +candidate_21982954 pos=16:86199584-86199624 -50.602 -317.300 -0.860 43.08 AAAACAAAATTTGCAAGCATCTGGAATGGCTGGTAAGTGC +candidate_21983199 pos=16:19155514-19155554 -51.259 -309.800 -0.834 45.37 AAAACAAAATTTGGGTGGGAGGTGGGAAAGTTCTGGGAGA +candidate_22007903 pos=16:87129728-87129768 -48.032 -313.800 -0.857 40.30 AAAACAAACAAAACACTCAGTTCATCGGGTAAAGTCTAGG +candidate_22008965 pos=16:85166641-85166681 -48.886 -312.700 -0.851 41.54 AAAACAAACAAAACCAGAAACCAAACCCCTTTTACCTGTG +candidate_22009936 pos=16:13198354-13198394 -51.023 -318.000 -0.861 43.60 AAAACAAACAAAACGGGCCAAGCAGAAACCTATCTGTAGC +candidate_22012273 pos=16:31196757-31196797 -49.771 -310.700 -0.841 43.19 AAAACAAACAAAAGTATCACCCTATCGCCCTAGGTAGCCT +candidate_22067700 pos=16:79178510-79178550 -50.290 -313.700 -0.849 43.27 AAAACAAACAAACAAACAACCTGTCTGCCTCTTCCCTCAA +candidate_22070025 pos=16:95161906-95161946 -47.425 -312.200 -0.854 39.68 AAAACAAACAAACAAACAGGAGCACAGTCATAATATTCCC +candidate_22070415 pos=16:60163443-60163483 -47.922 -314.000 -0.858 40.03 AAAACAAACAAACAAACATGGTCAGAATGCAGAGTTATGG +candidate_22072895 pos=16:11187568-11187608 -48.698 -314.000 -0.855 41.10 AAAACAAACAAACAAAGATGAGCCTTTGAAGCCCTAGAAC +candidate_22077731 pos=16:67178091-67178131 -49.229 -314.500 -0.855 41.70 AAAACAAACAAACAAGAACAACAAAATCCCAGCCAGATGG +candidate_22077881 pos=16:15134201-15134241 -47.377 -313.300 -0.857 39.46 AAAACAAACAAACAAGACCTAAAACTGTCCTGTAACAGTG +candidate_22080165 pos=16:12188710-12188750 -50.601 -310.600 -0.838 44.28 AAAACAAACAAACACAAAGCCTATCCATCCCCATGGGTCT +candidate_22080497 pos=16:32111082-32111122 -48.722 -313.900 -0.855 41.05 AAAACAAACAAACACACACCAACCAGAAGCAGAATGTTTA +candidate_22080830 pos=16:64121803-64121843 -48.658 -311.200 -0.846 41.49 AAAACAAACAAACACCATAAGAAGAGCCAGCCAGAATAGT +candidate_22082335 pos=16:50179734-50179774 -50.064 -316.700 -0.860 42.50 AAAACAAACAAACAGCATGGTGACACATGTTTGTAGTCCC +candidate_22082778 pos=16:25112695-25112735 -48.251 -315.600 -0.862 40.20 AAAACAAACAAACAGTCGAACAAACAAACCCCAATCATAC +candidate_22083540 pos=16:30140025-30140065 -48.909 -315.700 -0.860 41.11 AAAACAAACAAACATGGCCAAGTCTATCGTAGAAAATGCC +candidate_22088458 pos=16:78160661-78160701 -49.607 -312.800 -0.849 42.44 AAAACAAACAAAGAAAAGAAACTGGCAAGGATGCAGGGAA +candidate_22089455 pos=16:26154863-26154903 -48.584 -313.700 -0.855 41.01 AAAACAAACAAAGACACAGACAAACAGACAGAGAGACTGA +candidate_22090997 pos=16:51143275-51143315 -47.539 -312.500 -0.854 39.78 AAAACAAACAAAGTTAGTAAGGCACTTGTCAATTCCCATG +candidate_22097738 pos=16:48156249-48156289 -48.641 -312.300 -0.850 41.30 AAAACAAACAACAAAAGAGAGAGCTGAAAGGGACTGTACA +candidate_22102208 pos=16:28116722-28116762 -49.123 -317.000 -0.864 41.18 AAAACAAACAACATACACTTGATATTGTCAAGCAAGGCCG +candidate_22107943 pos=16:17193782-17193822 -50.532 -320.300 -0.870 42.42 AAAACAAACAAGCAAACAAAACAACAACATCAGCACTGGC +candidate_22108944 pos=16:90137828-90137868 -50.663 -315.500 -0.854 43.55 AAAACAAACAAGCAAAGACAACCCACAGGGCTGGTAATAC +candidate_22111133 pos=16:17108267-17108307 -48.510 -312.200 -0.850 41.25 AAAACAAACAAGGAGCTGGAGAAATAGCTCAGAGGTTAAG +candidate_22111571 pos=16:76106687-76106727 -51.337 -312.700 -0.843 44.98 AAAACAAACAAGGTCATAGCTCAGGGCTGTTCTGCCCTAT +candidate_22115072 pos=16:41106475-41106515 -47.162 -310.200 -0.848 39.75 AAAACAAACAATCTTAACTACTACCACTACCACCACCATC +candidate_22117822 pos=16:45173818-45173858 -49.333 -311.100 -0.844 42.47 AAAACAAACACAAATCTTTATCTACCTCCCTGAGCAGCCA +candidate_22120338 pos=16:5155136-5155176 -48.786 -312.600 -0.851 41.43 AAAACAAACACACTCAAGAAACTGTTCCACTCATGGAGAA +candidate_22121522 pos=16:23101375-23101415 -48.728 -313.100 -0.852 41.28 AAAACAAACACATACAAACAACCAGTACAGTAGTGCCAGA +candidate_22126700 pos=16:90130090-90130130 -48.058 -310.600 -0.847 40.72 AAAACAAACACTTCTTCCCTTTATTTGCTTTCTCCAGCAT +candidate_22128391 pos=16:66105689-66105729 -49.388 -311.000 -0.844 42.55 AAAACAAACAGAAAGGAAAGATTCTGGAAGAGGCACAGGA +candidate_22129434 pos=16:12190394-12190434 -50.256 -315.000 -0.854 43.01 AAAACAAACAGAAGGAAAAGAGCCAAGCGAAGGCATAAGA +candidate_22132000 pos=16:75198974-75199014 -48.506 -315.700 -0.862 40.51 AAAACAAACAGAGTGTGACATGTGTCGATTTCAGACAAAA +candidate_22133710 pos=16:87137068-87137108 -52.395 -314.100 -0.844 46.21 AAAACAAACAGCAGTATCCAGATCAGCTGCATCCCTCCCA +candidate_22133726 pos=16:96130849-96130889 -51.448 -315.200 -0.850 44.70 AAAACAAACAGCAGTGGCTACCACACAGTCATAGACCTGA +candidate_22134530 pos=16:13118550-13118590 -50.762 -313.800 -0.848 44.06 AAAACAAACAGCTAGAAGTCAGATTGGGGATCCAAGCTGG +candidate_22134652 pos=16:57199201-57199241 -55.472 -324.000 -0.866 48.74 AAAACAAACAGCTCGAGAGAGCACTCCTCGTCCCCAGTGC +candidate_22135831 pos=16:73178578-73178618 -49.293 -313.200 -0.851 42.08 AAAACAAACAGGATATTGAATGCCATGAAGGAGGCTGTTC +candidate_22136880 pos=16:73124496-73124536 -50.491 -310.800 -0.839 44.21 AAAACAAACAGGCTTCTGGATAGAGGAAGAGGTGTGGAGA +candidate_22137318 pos=16:66107612-66107652 -48.452 -312.700 -0.852 40.90 AAAACAAACAGGGTCAAGTTGGTTCAACACTTGTGTTTTA +candidate_22138543 pos=16:10153026-10153066 -48.528 -312.000 -0.849 41.30 AAAACAAACAGTATGATGGTCTAAGTTGGGCCATAGACAC +candidate_22139014 pos=16:66135997-66136037 -48.942 -313.500 -0.853 41.49 AAAACAAACAGTGCAACTTGAGATTCTATGCCAACAGAGA +candidate_22139245 pos=16:30109118-30109158 -50.375 -318.500 -0.864 42.61 AAAACAAACAGTGTGCTTTGCAAGGATGCAGTCATACTTG +candidate_22140417 pos=16:42198376-42198416 -48.457 -315.000 -0.859 40.55 AAAACAAACATAACAATGCAATGGAATCCAGCTTTGCTTC +candidate_22142541 pos=16:83147797-83147837 -49.693 -313.600 -0.851 42.63 AAAACAAACATATCTAGGCAAGACTAACCAGTGGCCACAG +candidate_22143830 pos=16:74196682-74196722 -49.850 -310.500 -0.840 43.23 AAAACAAACATCCCCAAAGGCTTTGATATCCCATTCAGCA +candidate_22143879 pos=16:68111670-68111710 -50.260 -315.500 -0.855 42.94 AAAACAAACATCCGTGTTGACAGCCCACTATTTCACAGAA +candidate_22144385 pos=16:46108727-46108767 -52.639 -318.500 -0.857 45.77 AAAACAAACATCTGTGCTCAGGGGCTGCTGTAAGTGGTTC +candidate_22153094 pos=16:32194021-32194061 -52.132 -317.000 -0.854 45.17 AAAACAAACCAAACAAAAGGCAGCACTGGTTGCTCTTCCA +candidate_22154498 pos=16:63139745-63139785 -46.913 -309.300 -0.846 39.47 AAAACAAACCAAAGGAGACAAGCTTAGAATGTAGTAGACA +candidate_22155674 pos=16:34122313-34122353 -50.571 -317.300 -0.860 43.15 AAAACAAACCAACAATCGTAACTAGGAGGGAAAACGGCAG +candidate_22155947 pos=16:44159950-44159990 -50.853 -316.000 -0.855 43.71 AAAACAAACCAACATCCTGCTTTCACATTGAAGGGCAGAG +candidate_22156764 pos=16:29182366-29182406 -49.487 -309.300 -0.838 42.95 AAAACAAACCAACTCATCCTAACACAGGGTTTCCCCTTTT +candidate_22157299 pos=16:50159646-50159686 -51.315 -311.500 -0.839 45.15 AAAACAAACCAAGCATCCATGGGTGGGGAGTGAGTAAGAA +candidate_22158341 pos=16:50123922-50123962 -50.085 -312.100 -0.845 43.27 AAAACAAACCAATTAAGCAGGTGAATATTGGCTGGGCTGA +candidate_22159085 pos=16:27143471-27143511 -47.200 -311.200 -0.851 39.55 AAAACAAACCACAGCAGAAAATAGAAGGGATGAAAAGAAG +candidate_22160134 pos=16:88124329-88124369 -50.290 -313.700 -0.849 43.27 AAAACAAACCACTCTCACCCCAAGAAAGCAAGACACAAAA +candidate_22161492 pos=16:90147842-90147882 -48.277 -313.300 -0.855 40.68 AAAACAAACCAGCAGGGTAACAGTCTTTAGCTAATTTGTG +candidate_22162118 pos=16:44151172-44151212 -53.231 -316.300 -0.848 47.01 AAAACAAACCAGGGAGTTGCTTCTGGGGTCCAGCTTTGAG +candidate_22162200 pos=16:11163816-11163856 -51.440 -312.400 -0.841 45.16 AAAACAAACCAGGGTCTCAAATAGCCCAGCTTGGCTATGA +candidate_22163643 pos=16:57158167-57158207 -46.901 -311.800 -0.854 39.08 AAAACAAACCATCTGGCACAATTAACTGACTGTACTTATC +candidate_22164411 pos=16:82101203-82101243 -47.785 -308.900 -0.842 40.63 AAAACAAACCATTGAAACACTGATGAACCAAATAGGGGAA +candidate_22165988 pos=16:63157019-63157059 -48.311 -308.000 -0.837 41.55 AAAACAAACCCAATCAAGACCCCTAAATGGTAGCATTTCT +candidate_22167297 pos=16:88195353-88195393 -50.811 -315.400 -0.853 43.65 AAAACAAACCCAGTGATTGGCATGGCTCGAAATGTTTTCT +candidate_22167603 pos=16:49183383-49183423 -53.059 -316.500 -0.849 46.65 AAAACAAACCCATGATCCAGACAGGCTCTGTGCAGATGCA +candidate_22168403 pos=16:92162192-92162232 -50.591 -310.900 -0.839 44.22 AAAACAAACCCCAGATGCATGCCCATAGGTCAATCAGATT +candidate_22168417 pos=16:57136534-57136574 -50.869 -314.900 -0.851 44.01 AAAACAAACCCCAGCCAAGTACAGTAGTGACAGTTCCTTG +candidate_22168459 pos=16:74173913-74173953 -51.546 -316.600 -0.855 44.59 AAAACAAACCCCAGGCACATTCCTTATAGCCGTGTTATGC +candidate_22168537 pos=16:11170884-11170924 -51.692 -312.900 -0.842 45.40 AAAACAAACCCCATCCCACCTCAGCTTCATTACTGCACTT +candidate_22169674 pos=16:48189398-48189438 -49.484 -309.700 -0.839 42.89 AAAACAAACCCGGGTATGCCCCTTAGTTAAAACATTCCTT +candidate_22169694 pos=16:16192234-16192274 -51.072 -313.800 -0.847 44.45 AAAACAAACCCGGTATGCCCCATAGTTAAAGCATTCCTGG +candidate_22169998 pos=16:9169681-9169721 -48.556 -308.400 -0.838 42.00 AAAACAAACCCTACCTTAATGGGAGATATCACAGACTGGG +candidate_22170395 pos=16:45154949-45154989 -49.151 -310.700 -0.843 42.40 AAAACAAACCCTCCCTTCCTTAACTGAAGTTTCCTAGCTC +candidate_22171219 pos=16:11135198-11135238 -50.539 -310.600 -0.839 44.20 AAAACAAACCCTTCCCTCCCCAAGTAGCTTTTGTTCATGT +candidate_22171832 pos=16:68188884-68188924 -48.210 -311.900 -0.850 40.81 AAAACAAACCGAAAGTACCTGGACATACGAACCTTTCTAT +candidate_22174961 pos=16:91126021-91126061 -48.864 -310.600 -0.844 41.95 AAAACAAACCTCCACAGAGCTTACTCAATTCTCTGAAGGA +candidate_22175427 pos=16:92181887-92181927 -49.036 -309.500 -0.840 42.34 AAAACAAACCTCTCATCAGGATGGAAAAGTACCAACCTGT +candidate_22179958 pos=16:5111686-5111726 -54.245 -317.500 -0.849 48.11 AAAACAAACGAAACACCATTGCTGGGTGCCAGGAGAGGGA +candidate_22185338 pos=16:65122594-65122634 -48.427 -311.000 -0.847 41.33 AAAACAAACTAAACCCATAGACAACTGTATTGCCTCCTCC +candidate_22185583 pos=16:8163848-8163888 -47.567 -308.000 -0.840 40.60 AAAACAAACTAAAGGAGAGTAAAGAAGAGTCACCAACCCT +candidate_22188201 pos=16:55133103-55133143 -48.866 -312.400 -0.850 41.66 AAAACAAACTACATGCCAGGAGTTTCCTTTTCCTCTTGAG +candidate_22188735 pos=16:81153500-81153540 -47.717 -311.500 -0.851 40.15 AAAACAAACTACTGCAGTCACTCAGGAAATTGTTGAGAAT +candidate_22190073 pos=16:13184132-13184172 -47.217 -310.100 -0.848 39.83 AAAACAAACTAGGTGGGAAAGAGTTTACTTTGAGTGGTAG +candidate_22192227 pos=16:27164290-27164330 -47.196 -309.800 -0.847 39.75 AAAACAAACTCAAACAAATCAGTAGCCTTCCTCTACTCAA +candidate_22192745 pos=16:48174894-48174934 -50.821 -314.200 -0.849 43.96 AAAACAAACTCAAGATTCTGCTTGAGTGACAGGGCCTTCA +candidate_22193410 pos=16:40142209-40142249 -49.219 -310.800 -0.843 42.37 AAAACAAACTCACTATCAGAAATTGCCCAGCCTAGCCTAA +candidate_22193752 pos=16:43152789-43152829 -50.872 -314.500 -0.850 43.98 AAAACAAACTCAGCCAATGTTTGGAGGTTCCTCGTCTCAT +candidate_22193843 pos=16:90164453-90164493 -48.310 -311.100 -0.847 41.06 AAAACAAACTCAGGACTTTGTGAGCATCCATTATAGCTCA +candidate_22195602 pos=16:64101875-64101915 -48.710 -311.500 -0.847 41.61 AAAACAAACTCCTCTGTCCCAGGCTAATGGTTTATTTGTC +candidate_22196342 pos=16:18179921-18179961 -51.938 -315.100 -0.848 45.45 AAAACAAACTCTATGATCTGCCTGGTTACCCTGGCCAAGC +candidate_22197324 pos=16:11181750-11181790 -48.492 -309.700 -0.842 41.71 AAAACAAACTCTTCCTCCCATTCTACTAAGGACTGCTAGG +candidate_22197538 pos=16:7145407-7145447 -48.738 -312.800 -0.851 41.34 AAAACAAACTCTTTAGAGCTGGTGAATGCTTGTTCTCAGT +candidate_22198662 pos=16:24108652-24108692 -48.182 -315.500 -0.862 40.13 AAAACAAACTGACAAACAGAAAACAAAAGAGCACTCCTTG +candidate_22199438 pos=16:84113940-84113980 -49.377 -314.400 -0.855 41.90 AAAACAAACTGATACACGTGCAAAAGAGTGAATTTCCCCA +candidate_22199459 pos=16:39138516-39138556 -47.032 -311.900 -0.854 39.33 AAAACAAACTGATACTTGTCCACACAGTCTCTGATAGTAC +candidate_22200544 pos=16:97127845-97127885 -50.457 -312.100 -0.844 43.85 AAAACAAACTGCTGAACTACCCAATAAGATCCTGCCACCA +candidate_22200957 pos=16:31174384-31174424 -53.369 -316.500 -0.848 47.15 AAAACAAACTGGACAGGCAGTGACAGACTCCCAGAGCTGA +candidate_22201014 pos=16:75109753-75109793 -49.706 -311.100 -0.843 43.04 AAAACAAACTGGAGAAGCAAGTGGTGGAGTATCAGAGGTA +candidate_22202360 pos=16:8100518-8100558 -49.631 -313.600 -0.851 42.55 AAAACAAACTGTATAGAGGGTTTGTCCCTGTGCAGAAGAC +candidate_22202771 pos=16:66144420-66144460 -48.043 -313.500 -0.856 40.26 AAAACAAACTGTGACAAAGAGCCATCATTTCACGATCTTA +candidate_22203018 pos=16:93137335-93137375 -54.307 -318.400 -0.851 48.13 AAAACAAACTGTGTACCAGCCCAGACCCTGCTGTGGAACC +candidate_22205403 pos=16:57181778-57181818 -50.157 -316.700 -0.859 42.52 AAAACAAACTTCAATGTTCACACCACAAGATGCAGCAACA +candidate_22206827 pos=16:20161423-20161463 -47.467 -307.900 -0.840 40.38 AAAACAAACTTGAAGGGAATTAAGTAGGCATGGAGGTTTT +candidate_22207174 pos=16:81171525-81171565 -49.480 -319.000 -0.869 41.22 AAAACAAACTTGCAAAGTCATTGTGTTTGTTTGTGTTGGC +candidate_22207831 pos=16:40187696-40187736 -50.499 -311.800 -0.843 44.05 AAAACAAACTTGTCACTAGTCCAGTCCAGGGACTCAGACT +candidate_22208932 pos=16:62193639-62193679 -46.886 -310.700 -0.851 39.23 AAAACAAACTTTCAGAAGGAAGGCATAGTTCCTACAAAAG +candidate_22213516 pos=16:42184208-42184248 -48.455 -311.400 -0.848 41.20 AAAACAAAGAAAACCTCCGAGTTTCTGTCTACCCAAAGAA +candidate_22214148 pos=16:32110929-32110969 -54.526 -321.100 -0.859 47.73 AAAACAAAGAAAAGCAGAATGCAGGCCAAGCGGTGGCACT +candidate_22214644 pos=16:10161150-10161190 -48.338 -311.500 -0.848 41.04 AAAACAAAGAAAATAATAATTCTGTGTCCTTGCCAGGGGC +candidate_22218001 pos=16:6153321-6153361 -49.876 -313.100 -0.849 42.94 AAAACAAAGAAACTCCATCTTTGGGTCTAGTCATGCCCAC +candidate_22220205 pos=16:51104997-51105037 -47.858 -310.400 -0.846 40.50 AAAACAAAGAAAGCAAAGGAGAATGACTGTGGGTTTTACT +candidate_22221967 pos=16:78121594-78121634 -47.299 -308.600 -0.843 40.06 AAAACAAAGAAATCAACAGGCTATCACATCTTCCCTTTCT +candidate_22226467 pos=16:85140359-85140399 -45.506 -306.900 -0.843 38.04 AAAACAAAGAAGAAGGATAGAAGGAACCAGAGAGATAAAG +candidate_22230471 pos=16:48150618-48150658 -47.989 -310.500 -0.846 40.85 AAAACAAAGAATATTACCAAGGACCACTCCACTCTGTCTC +candidate_22231264 pos=16:35100492-35100532 -48.555 -312.400 -0.851 41.17 AAAACAAAGAATGAATGAATTCAGGCATGGTGATTCACCC +candidate_22231544 pos=16:62146595-62146635 -49.106 -311.400 -0.846 42.03 AAAACAAAGAATGGACAGCCATGCCACAATAATGGAAGAA +candidate_22234415 pos=16:53153978-53154018 -52.904 -317.400 -0.853 46.19 AAAACAAAGACAACCACTGCATGTGGGCTGATGTGCCTTT +candidate_22235188 pos=16:84110136-84110176 -46.972 -309.700 -0.847 39.48 AAAACAAAGACACAGATACTTAACTGGGTATACAAGTGCA +candidate_22235294 pos=16:85110795-85110835 -51.412 -317.800 -0.859 44.13 AAAACAAAGACACATGCGTACACACATGGCCTCATTCAGA +candidate_22235562 pos=16:66120355-66120395 -49.524 -312.500 -0.848 42.48 AAAACAAAGACACTGAGCTGGGAGAAAAGATTGCTCTCTT +candidate_22237073 pos=16:95114060-95114100 -48.645 -312.800 -0.852 41.12 AAAACAAAGACATCATGAAATTTGCAGGCAATGGACAGAA +candidate_22238881 pos=16:91149318-91149358 -47.688 -308.400 -0.841 40.69 AAAACAAAGACCCAGAGAAGTTAAGTCATGCAAGGGTATA +candidate_22240123 pos=16:58145273-58145313 -51.590 -315.000 -0.849 45.02 AAAACAAAGACTAACACCCTAGGGCGTTCTCCAACTTCCC +candidate_22240135 pos=16:32114579-32114619 -48.202 -309.100 -0.841 41.34 AAAACAAAGACTAACCATCACATACGACCTGGATACCCTA +candidate_22240291 pos=16:18162248-18162288 -51.020 -313.500 -0.846 44.54 AAAACAAAGACTACTTACATCCAGCCCCTCTGGAGCTCTG +candidate_22242413 pos=16:97176240-97176280 -49.272 -307.100 -0.831 43.14 AAAACAAAGAGAAAATGAAGAAGAGGGAGGGAGGGAGGAA +candidate_22242847 pos=16:41171621-41171661 -47.134 -309.800 -0.847 39.77 AAAACAAAGAGAAATGTTCCTACCTGGTAACACATAGGAC +candidate_22243294 pos=16:91118707-91118747 -51.772 -314.500 -0.847 45.24 AAAACAAAGAGAAGCAGCACTGGGAGACAAGGTCACCAAT +candidate_22244228 pos=16:6117975-6118015 -47.962 -311.900 -0.851 40.50 AAAACAAAGAGAGAAACACACAGAGAGAAACACAGAGAGA +candidate_22244542 pos=16:31144986-31145026 -53.922 -314.200 -0.839 48.49 AAAACAAAGAGAGAGGTGCAAGAGGGAGTGGGGAGGGGTC +candidate_22245248 pos=16:90156432-90156472 -51.655 -315.500 -0.851 45.02 AAAACAAAGAGATCTGTCTTCCTCTGCCTCCCAAGTGCTG +candidate_22246691 pos=16:5178259-5178299 -53.880 -318.500 -0.853 47.56 AAAACAAAGAGCTAGGCACTCGGGAGGTTGAGGCAGGAAG +candidate_22248005 pos=16:68163705-68163745 -50.953 -317.000 -0.858 43.68 AAAACAAAGAGGCCTTGACGATTCTATGGAACACACGTGA +candidate_22249466 pos=16:53198620-53198660 -49.067 -309.500 -0.840 42.38 AAAACAAAGAGTCATTCAAGCTGAAGGGGAATTGGTAGGA +candidate_22249903 pos=16:20170601-20170641 -47.951 -310.400 -0.846 40.62 AAAACAAAGAGTGTAATGAACCTCCATGTGCCAAATCAAT +candidate_22250312 pos=16:3109155-3109195 -57.270 -323.100 -0.857 51.21 AAAACAAAGAGTTGGGCCGGGCGTGGTGGCACACACCTTT +candidate_22251468 pos=16:51149587-51149627 -47.152 -310.500 -0.849 39.59 AAAACAAAGATACAAGTAACACAATACAGACTGAGCTGGT +candidate_22251480 pos=16:62192811-62192851 -47.891 -308.200 -0.839 40.98 AAAACAAAGATACAATGGTTGAGGATATGCCTCTGTGGAT +candidate_22254279 pos=16:39105899-39105939 -51.425 -311.300 -0.838 45.33 AAAACAAAGATGAAGAAACACCCAGATCCAACTGGGGCCT +candidate_22263227 pos=16:65100596-65100636 -51.317 -315.100 -0.850 44.35 AAAACAAAGCAAACAAAACAAAAGCCAGCCCTGTTTCCCT +candidate_22264711 pos=16:96115374-96115414 -50.413 -317.700 -0.862 42.78 AAAACAAAGCAAAGCAAAATCAGCAGACAGTCTGTTTCCC +candidate_22266827 pos=16:46140996-46141036 -50.134 -312.800 -0.847 43.21 AAAACAAAGCAACTTGGGTAGGAAAAGGTGTGTTTGGCTA +candidate_22267124 pos=16:64124738-64124778 -48.407 -312.500 -0.852 40.87 AAAACAAAGCAAGACCCAACAGCTACAAGAAAACTGAAAT +candidate_22267784 pos=16:93148087-93148127 -52.876 -316.100 -0.849 46.59 AAAACAAAGCAAGGCAAGGTCAAGAGGTAGCCTGGGAGAG +candidate_22267986 pos=16:49132159-49132199 -48.221 -312.500 -0.852 40.73 AAAACAAAGCAAGTCTCCCTTGTCCAAGAAAAGAATGATC +candidate_22270008 pos=16:37196041-37196081 -46.586 -309.500 -0.848 39.02 AAAACAAAGCACCCATATCATAAATCATTCTCTGGATCAC +candidate_22270492 pos=16:68171225-68171265 -49.929 -315.200 -0.855 42.67 AAAACAAAGCACTGGAAGTCAAATCACGGGGTCTATACTG +candidate_22270800 pos=16:57163111-57163151 -48.599 -310.800 -0.845 41.48 AAAACAAAGCAGAAACACTCTCTAGGAAGGGAATGCTTTT +candidate_22272621 pos=16:78164887-78164927 -53.425 -318.200 -0.854 46.93 AAAACAAAGCAGGGCTGCCTTGGCTAGAAGGACAAGTGAG +candidate_22274021 pos=16:18122906-18122946 -54.205 -319.600 -0.856 47.68 AAAACAAAGCATATTTGCACTCCCTGTGGGTGGCAGTGGC +candidate_22274554 pos=16:4153705-4153745 -51.935 -316.400 -0.853 45.23 AAAACAAAGCATGAGAGAGGGAGGCAGGCAGTACATAAGC +candidate_22274607 pos=16:25188474-25188514 -50.449 -320.000 -0.869 42.47 AAAACAAAGCATGATGTGTATGTGTGTGTGTGTGTGTGTG +candidate_22274960 pos=16:18191168-18191208 -50.586 -314.400 -0.851 43.63 AAAACAAAGCATGTTATGAAATCCCAGAGAAGCCCATGGC +candidate_22275089 pos=16:64170152-64170192 -48.129 -313.400 -0.855 40.38 AAAACAAAGCATTAGCAAGTGCAATAGCATTGCTACTAGA +candidate_22276314 pos=16:55137295-55137335 -48.757 -310.400 -0.844 41.84 AAAACAAAGCCAAATCCTCTATTTTGTGAGAAGGGAAGGG +candidate_22276407 pos=16:48163864-48163904 -51.159 -314.600 -0.849 44.43 AAAACAAAGCCAACAGAGAAGTCGTAGCCTCAACCCTCTA +candidate_22277296 pos=16:15184133-15184173 -50.500 -313.600 -0.848 43.75 AAAACAAAGCCACTCCTAGGCTCCTTGCTATTTGTAGGAC +candidate_22277386 pos=16:80198612-80198652 -47.157 -308.800 -0.844 39.85 AAAACAAAGCCAGAAAGTGAATTACTGACCCAAGATTCTA +candidate_22278994 pos=16:48190339-48190379 -52.566 -321.900 -0.868 45.11 AAAACAAAGCCCAGAGAACTAGACGAAGAGCAAGCGTAGC +candidate_22279207 pos=16:90183096-90183136 -51.432 -317.200 -0.857 44.35 AAAACAAAGCCCATTATCTTACACAGAGCAGTGCTGAGGC +candidate_22279494 pos=16:92122139-92122179 -47.931 -311.000 -0.848 40.60 AAAACAAAGCCCCTGACTAATGAATTAAAGAGGAATGCAG +candidate_22281771 pos=16:13160190-13160230 -53.506 -326.500 -0.880 45.43 AAAACAAAGCGAACAGAAATGTGCAGGTACTTTTGCGGCG +candidate_22281774 pos=16:49153622-49153662 -52.541 -321.100 -0.866 45.11 AAAACAAAGCGAACCAAAAGCAGTGCTTGGATGGTGAGAC +candidate_22283034 pos=16:49153168-49153208 -47.976 -311.200 -0.849 40.62 AAAACAAAGCTACAGAGTGAGAGTGGTAAGAAGATGTGTT +candidate_22283133 pos=16:55104509-55104549 -53.175 -314.600 -0.843 47.24 AAAACAAAGCTACCTCCCTCACAGACATGCCCACAGGCTA +candidate_22285544 pos=16:43157945-43157985 -50.593 -313.600 -0.848 43.77 AAAACAAAGCTGCCACAGCAATGTTAGTATCAGGAGACCT +candidate_22285837 pos=16:47151351-47151391 -48.298 -314.500 -0.858 40.43 AAAACAAAGCTGGCAAACAATTTAGTTTGTAAAGTGGGTG +candidate_22289175 pos=16:15136403-15136443 -48.584 -308.800 -0.839 41.87 AAAACAAAGGAAACCTGAAGTGTCCCTAGACATGACCTAA +candidate_22291090 pos=16:31132942-31132982 -50.223 -311.400 -0.842 43.66 AAAACAAAGGAAGGAAGAAAGGAAAGAAAGGAGCGAGGGA +candidate_22292624 pos=16:54121626-54121666 -48.300 -311.400 -0.848 41.10 AAAACAAAGGACAGCAATAGGTGAAACTAGGTCACTAAGG +candidate_22292665 pos=16:8111403-8111443 -54.637 -322.700 -0.864 47.69 AAAACAAAGGACAGGCTGCAACCAGCAACTCTGCTTGCTG +candidate_22293865 pos=16:55185288-55185328 -45.749 -305.500 -0.837 38.56 AAAACAAAGGAGACCTACACTATACCATGCTTATAGATCA +candidate_22294429 pos=16:31104483-31104523 -50.382 -311.900 -0.843 43.78 AAAACAAAGGAGCTAATTAAGCCAATGAGCAGCCTCCTCT +candidate_22294609 pos=16:73178356-73178396 -49.000 -307.200 -0.833 42.77 AAAACAAAGGAGGAGAAGAAAAGGAAGAGGAGAAGGAGGA +candidate_22297174 pos=16:60175876-60175916 -48.286 -311.200 -0.848 40.92 AAAACAAAGGCAAGCAGGGATGTTTGTTCTAATTAAGCAT +candidate_22297925 pos=16:46186219-46186259 -52.857 -314.500 -0.844 46.74 AAAACAAAGGCAGAGAGTCCAGATTTGCCTGGCCCAAAGA +candidate_22298648 pos=16:24187087-24187127 -49.062 -313.000 -0.851 41.82 AAAACAAAGGCATCCTGGCCTGTTAGAAACTAAGTTTCAG +candidate_22298997 pos=16:26100961-26101001 -49.535 -313.100 -0.850 42.30 AAAACAAAGGCCAAATCTCACAAAGCACCAAGTCAAGAAT +candidate_22299683 pos=16:10168337-10168377 -47.932 -307.900 -0.838 41.08 AAAACAAAGGCCTAATCCATCAAAGTTCATAGTTCTGGGA +candidate_22300372 pos=16:11141090-11141130 -50.850 -316.400 -0.856 43.74 AAAACAAAGGCTAGAGAGATGGCTCAGCAGTTAAGAGCAC +candidate_22300595 pos=16:42103309-42103349 -48.658 -311.200 -0.847 41.49 AAAACAAAGGCTCACTTTCTATAGCACCAACACTTGGATT +candidate_22300923 pos=16:97165790-97165830 -53.878 -315.800 -0.844 47.94 AAAACAAAGGCTGCAGACCATCTCTGACCTGCCAAACCCT +candidate_22300972 pos=16:31194128-31194168 -51.191 -316.400 -0.855 44.18 AAAACAAAGGCTGCTTGACCACAGGCACTACAATACTACC +candidate_22302074 pos=16:5109235-5109275 -52.277 -312.400 -0.839 46.35 AAAACAAAGGGAACTGGGGTTGAAGAGATGGCTCAGTGGT +candidate_22302160 pos=16:90124634-90124674 -54.655 -318.500 -0.851 48.46 AAAACAAAGGGAAGCCCAGCAGCAAGGCAGCTGCATCTAA +candidate_22302865 pos=16:13127182-13127222 -56.248 -314.200 -0.832 51.89 AAAACAAAGGGAGGGAGGAGGGGAGCGGAGAGGAGGGGAG +candidate_22305091 pos=16:15186089-15186129 -54.771 -316.600 -0.844 49.16 AAAACAAAGGGGTGGGAAACCCATCTCCCACCAGAGCTCG +candidate_22305276 pos=16:12138525-12138565 -48.408 -313.400 -0.854 40.73 AAAACAAAGGGTACACAAAGTAAATTGTGTGTGTGTGTGT +candidate_22306763 pos=16:54145774-54145814 -49.800 -313.800 -0.851 42.73 AAAACAAAGGTAGCAAATTCACCCAAGAGGAGTAGACAGC +candidate_22306792 pos=16:32126901-32126941 -50.691 -316.800 -0.858 43.38 AAAACAAAGGTAGCCTGCTCACCAACATTGGAAAATCGAG +candidate_22307094 pos=16:13176077-13176117 -46.777 -306.900 -0.839 39.66 AAAACAAAGGTATGATCACACTATCCCAAGAAGGTTTTCT +candidate_22307991 pos=16:34107515-34107555 -48.737 -310.100 -0.843 41.86 AAAACAAAGGTCTTCTCGGTGTATATCCTGTCCTTTTGGA +candidate_22308271 pos=16:93102076-93102116 -54.369 -318.400 -0.851 48.11 AAAACAAAGGTGAGCAGGCTAATTCGGTGCCTGGAGCCAA +candidate_22308782 pos=16:39186247-39186287 -50.663 -315.500 -0.854 43.55 AAAACAAAGGTGGTAAATGCTGGTGAAGGTGTGGCTAAAC +candidate_22309502 pos=16:18197471-18197511 -52.018 -311.800 -0.838 46.22 AAAACAAAGGTTCCTCCTTTCAGATCCCCACAGGGTCTCC +candidate_22309582 pos=16:77139315-77139355 -48.553 -308.800 -0.839 41.83 AAAACAAAGGTTCTTCTAAGTGGTAGTGGGACAGAAGGAA +candidate_22311802 pos=16:72102985-72103025 -46.505 -307.000 -0.840 39.29 AAAACAAAGTAAATGTCATAAGTTCTCCTCCTCTTGTCCT +candidate_22317162 pos=16:93153957-93153997 -48.733 -310.500 -0.844 41.69 AAAACAAAGTATGAAGGAGAAATGTTGGTGAGGGTTGCAT +candidate_22322429 pos=16:10191280-10191320 -47.889 -310.400 -0.846 40.54 AAAACAAAGTCTCTGCTGGGCTTTCTTGAAATTTCCTTTA +candidate_22322736 pos=16:70183950-70183990 -50.046 -310.200 -0.839 43.63 AAAACAAAGTCTGGGGTTTGGCACTACCACATCCTATTCT +candidate_22324337 pos=16:86170469-86170509 -46.394 -305.400 -0.835 39.39 AAAACAAAGTGACTAGGATAGGGAAGGTTGGAACTTTTAT +candidate_22325033 pos=16:18199206-18199246 -53.316 -314.400 -0.842 47.46 AAAACAAAGTGATGCTGAGGGCCCATGAGGAGGCTACAGT +candidate_22325960 pos=16:88141120-88141160 -52.805 -318.200 -0.856 45.93 AAAACAAAGTGCTTCATCAAATGCAGGCACCGGCTGGATA +candidate_22328152 pos=16:76113352-76113392 -55.261 -323.200 -0.864 48.40 AAAACAAAGTGTGGGGAGCCGCGCGGGTAATAACAAAGCA +candidate_22331015 pos=16:26162478-26162518 -52.987 -312.800 -0.838 47.21 AAAACAAAGTTCCAAGGGGCCAATCCCTAGGCCAAAAGCA +candidate_22334198 pos=16:75129428-75129468 -47.914 -312.100 -0.852 40.31 AAAACAAAGTTTGAGATTAAGCTCAAACCTTGCAGAGCTA +candidate_22334282 pos=16:33149008-33149048 -46.873 -311.400 -0.853 39.11 AAAACAAAGTTTGCCACTCTTGGCATATCTAAGACTTTAG +candidate_22337724 pos=16:96115203-96115243 -50.103 -317.700 -0.863 42.39 AAAACAAATAAAACACACATCTCGAAACTCCAATGGCGGG +candidate_22342579 pos=16:44128322-44128362 -52.685 -314.700 -0.845 46.48 AAAACAAATAAACCTATGAGCTGGAGCAAGTGGGGCCGGA +candidate_22344144 pos=16:15131264-15131304 -46.571 -307.500 -0.841 39.30 AAAACAAATAAATAAAACCAACTCCTGAATCCCCTTCCTG +candidate_22348223 pos=16:60138660-60138700 -47.141 -309.900 -0.847 39.67 AAAACAAATAACAGTACATGCTGGCAAAGAGGTAGAGTAA +candidate_22349222 pos=16:51186899-51186939 -47.665 -310.300 -0.847 40.27 AAAACAAATAACCGCATTAAAATATGGGGCTCAGAGCTAA +candidate_22349836 pos=16:39185937-39185977 -51.805 -317.200 -0.856 44.93 AAAACAAATAACTGAGCAGAGAGGAAGCCCACGGAGTGAG +candidate_22350221 pos=16:76188356-76188396 -48.247 -309.300 -0.842 41.36 AAAACAAATAAGAAACTCACAAAGAGGAAGGAAGGGAGGG +candidate_22354848 pos=16:6143948-6143988 -51.661 -313.800 -0.845 45.11 AAAACAAATAATGGGAAATGCTGGCAAGGGCTCAGGCAAA +candidate_22355635 pos=16:60105525-60105565 -47.669 -311.700 -0.851 40.06 AAAACAAATAATTGGTTTTGAAGGCTCAGCCCTAAACATG +candidate_22356305 pos=16:88124318-88124358 -48.770 -313.700 -0.854 41.24 AAAACAAATACAAAACAAACCACTCTCACCCCAAGAAAGC +candidate_22357832 pos=16:20117628-20117668 -48.549 -313.200 -0.853 41.04 AAAACAAATACACAGTGTGCTTGTGGGATTAAAATGTCCC +candidate_22358340 pos=16:75187595-75187635 -47.864 -314.500 -0.860 39.99 AAAACAAATACAGACTCTTGTAGCACAGCAGTAGAAACAG +candidate_22359397 pos=16:72145410-72145450 -48.554 -309.700 -0.842 41.59 AAAACAAATACATGAATAAGTGGGTGGGGTGACACAATGT +candidate_22361207 pos=16:6135546-6135586 -49.583 -313.800 -0.852 42.35 AAAACAAATACGAGATCAGCCTGTTGGTACACTGCCAATA +candidate_22363266 pos=16:84123068-84123108 -46.816 -307.900 -0.842 39.55 AAAACAAATACTTTCTACAGTGAGGAAAATCCACAGAGGT +candidate_22363675 pos=16:54122567-54122607 -47.182 -308.700 -0.843 40.00 AAAACAAATAGAAACAAACCCATCCAAGAGGAGTAGAAGG +candidate_22366619 pos=16:36101464-36101504 -51.151 -312.700 -0.843 44.64 AAAACAAATAGCCCCAAGAAGGAATGTGCAAAAGGCCTGA +candidate_22369611 pos=16:14186124-14186164 -50.927 -313.500 -0.847 44.32 AAAACAAATAGTTTGCCCTGGTAAGAACCTGGTGTGGGTC +candidate_22373867 pos=16:93179825-93179865 -50.608 -316.500 -0.857 43.32 AAAACAAATATCATTGCCTTGTAGGGCAGCTTCAGGTTCG +candidate_22374476 pos=16:33181585-33181625 -51.426 -313.100 -0.844 45.03 AAAACAAATATCTAGCTGGGCCTGGTGATGCAGGCTGTAA +candidate_22375839 pos=16:6136459-6136499 -47.583 -311.800 -0.852 39.94 AAAACAAATATGCTCCCAAATGGCTTGTGTGTTTATTACC +candidate_22383821 pos=16:40125692-40125732 -52.753 -318.800 -0.858 45.76 AAAACAAATCAAGCAGAAAGCCCATGCGGATAAGAGCGGT +candidate_22384493 pos=16:53191793-53191833 -48.665 -311.300 -0.847 41.48 AAAACAAATCAATCTGACATTAGGCAGTGTTCTGGGTTGA +candidate_22385414 pos=16:76107708-76107748 -48.293 -312.200 -0.851 40.87 AAAACAAATCACATCGTATCACATCTCTCTGCCTAAACCA +candidate_22385976 pos=16:88127352-88127392 -49.873 -314.400 -0.853 42.73 AAAACAAATCACTCACTCCATCCTAGAAGAGCAAACTGCC +candidate_22388274 pos=16:41173653-41173693 -48.488 -314.100 -0.856 40.83 AAAACAAATCATAACCAGCTTTTCACAGGTTCAGAAGCTC +candidate_22389140 pos=16:90101042-90101082 -49.955 -312.900 -0.848 42.97 AAAACAAATCATGAGCCCACCTTTGCAGTGTTACCTTACA +candidate_22391255 pos=16:13108590-13108630 -52.435 -316.900 -0.853 45.68 AAAACAAATCCACTTGCAGCGGCTGATGTGAAGGGAGATT +candidate_22392409 pos=16:45124376-45124416 -49.820 -312.300 -0.846 42.89 AAAACAAATCCCACTTTGGTGGCACATATGTGTCATCTCA +candidate_22393590 pos=16:83170773-83170813 -47.311 -306.100 -0.834 40.66 AAAACAAATCCTACCTCCAGAGAAAGAGAGAGAGAGAGAT +candidate_22399452 pos=16:86120245-86120285 -48.937 -317.000 -0.864 40.95 AAAACAAATCTGATCTGCATTTTGATGCTGTACCGCTAAC +candidate_22402937 pos=16:87187631-87187671 -51.875 -314.200 -0.846 45.42 AAAACAAATCTTTGTGAGTTCAAGGCCTGCCCACTCTCCA +candidate_22404908 pos=16:52134574-52134614 -52.532 -323.200 -0.873 44.75 AAAACAAATGAAAGCCCGAGCGAACTTGCCTCACGTAATC +candidate_22406075 pos=16:60185472-60185512 -46.220 -308.700 -0.846 38.68 AAAACAAATGAACAATGATCTCTCCTATATGGTCACAAGG +candidate_22406780 pos=16:94123970-94124010 -53.990 -318.300 -0.852 47.64 AAAACAAATGAAGAAATGCCCGGCCTTGGGGACAGAAGCC +candidate_22409580 pos=16:15123716-15123756 -46.769 -310.800 -0.851 39.06 AAAACAAATGACAGTTCATGTTGGCAATCATAGAGGATAG +candidate_22409669 pos=16:64127159-64127199 -46.888 -312.500 -0.856 38.96 AAAACAAATGACATCTCATATTGGTGAGGACGTGAAATAC +candidate_22409934 pos=16:39186056-39186096 -48.754 -309.900 -0.842 41.82 AAAACAAATGACCCAATTAACAAATGGGCTATGGAGCTGA +candidate_22410844 pos=16:71175515-71175555 -47.423 -308.600 -0.842 40.22 AAAACAAATGACTTTACTGGCCCTGCCTACTTTTCTTATT +candidate_22411499 pos=16:14145787-14145827 -49.441 -312.200 -0.847 42.43 AAAACAAATGAGATAAGAGAGAGGCTCAAAAGGCTGCAGT +candidate_22412801 pos=16:66173972-66174012 -48.286 -311.200 -0.848 40.92 AAAACAAATGAGTTAAGCCATAAATGTCAGGCAAGCCTTT +candidate_22414716 pos=16:6125809-6125849 -52.316 -314.300 -0.845 45.97 AAAACAAATGATTGGCATGTTCAGTGGAGGGCCTGTTGGT +candidate_22416928 pos=16:55125756-55125796 -47.273 -311.800 -0.853 39.55 AAAACAAATGCATCAATCTAATGCTAGAAAGGAATCTGGC +candidate_22420280 pos=16:94159288-94159328 -50.595 -312.300 -0.844 43.99 AAAACAAATGCTTCCTCCCTTAAGTTGCACAGCCTAGGAA +candidate_22422286 pos=16:57100406-57100446 -47.088 -307.800 -0.841 39.92 AAAACAAATGGAGTCTCAAGGTACCCATAAATTGTGTCTT +candidate_22423546 pos=16:41192808-41192848 -47.830 -309.100 -0.842 40.66 AAAACAAATGGCCCAATTTGTCATTGCTATACCTCATCAT +candidate_22427785 pos=16:65176726-65176766 -48.207 -311.400 -0.849 40.98 AAAACAAATGTAGACCTGAGAACTTCATGTGAGAGATGGG +candidate_22431224 pos=16:56124062-56124102 -49.621 -313.900 -0.852 42.29 AAAACAAATGTGCTTTAATGGCTAGTGTGACTTTTGCCCA +candidate_22431606 pos=16:11140939-11140979 -50.239 -316.100 -0.857 42.92 AAAACAAATGTGGTGCACATCTTTACTCCAAGTACTCCGG +candidate_22431610 pos=16:13150836-13150876 -52.935 -316.500 -0.850 46.59 AAAACAAATGTGGTGGCCATCAGCCCTGTCCTCAGTAGTC +candidate_22432810 pos=16:10143517-10143557 -46.285 -308.300 -0.845 38.82 AAAACAAATGTTATCAGTCTGAAGGATAACATCCCTTTCC +candidate_22439916 pos=16:90141470-90141510 -49.361 -310.600 -0.842 42.68 AAAACAAATTACTGGGGAAGAGCCAGGAGAATCATCCAAG +candidate_22442846 pos=16:73115936-73115976 -48.184 -308.400 -0.839 41.32 AAAACAAATTATCTGGGTTTGGAGAGATGGTTCTGTGGTT +candidate_22445629 pos=16:16131714-16131754 -50.331 -314.300 -0.851 43.22 AAAACAAATTCACACATTGTCTTTCCACGAATCCAGCCCT +candidate_22446077 pos=16:44104803-44104843 -48.698 -314.000 -0.855 41.10 AAAACAAATTCAGAGACTGACACGGTTCATGTCTGAGAAA +candidate_22448911 pos=16:84178196-84178236 -49.099 -316.200 -0.861 41.37 AAAACAAATTCTACTGTCCTACTCACACACACACACACAC +candidate_22451921 pos=16:13142802-13142842 -51.321 -315.600 -0.852 44.47 AAAACAAATTGAGGCAGGGAGCCACCGAATGACTTATTCC +candidate_22454116 pos=16:6181586-6181626 -53.275 -315.600 -0.846 47.19 AAAACAAATTGGGCTACTGGGATGGCTCAGTGGGAAAGGC +candidate_22455527 pos=16:12145387-12145427 -49.831 -313.800 -0.851 42.77 AAAACAAATTGTGTCAGAGTATCTGGCTAAGGGGTTCTGC +candidate_22461655 pos=16:76185390-76185430 -52.210 -315.000 -0.847 45.82 AAAACAAATTTCTGGGGTGACACCTGCCTTCTTCCCTGTG +candidate_22462363 pos=16:38165907-38165947 -48.017 -311.800 -0.850 40.48 AAAACAAATTTGAGGTGAATCCTGTTTTACAGTAGCAGCA +candidate_22478627 pos=16:67150981-67151021 -47.647 -314.500 -0.860 39.62 AAAACAACAAAACAAGTAAACACTAGCATTCACTCACTGG +candidate_22481196 pos=16:97166331-97166371 -47.904 -311.500 -0.850 40.49 AAAACAACAAAAGACATACATACACTCCCATTTCCCACAG +candidate_22482990 pos=16:34149365-34149405 -47.116 -309.100 -0.845 39.75 AAAACAACAAAATATCATTGTCACCTCCTGCTCTAGATGT +candidate_22483304 pos=16:14130104-14130144 -50.640 -311.600 -0.841 44.16 AAAACAACAAAATCCCCACAAAGCACTCTAGGGTGATGGT +candidate_22483415 pos=16:96191713-96191753 -47.606 -309.900 -0.846 40.25 AAAACAACAAAATCTTAAAGCACTCATAGTGAGGTGGGTT +candidate_22486781 pos=16:28140215-28140255 -50.523 -312.600 -0.845 43.75 AAAACAACAAACAATCAAAGCCCATCCCTCAACCAACCAA +candidate_22487831 pos=16:20136212-20136252 -46.984 -307.200 -0.839 39.87 AAAACAACAAACCACTAAGGAAATTAGTGTTAGGGGTTCT +candidate_22488479 pos=16:4169917-4169957 -48.774 -315.100 -0.859 41.03 AAAACAACAAACTACTTTCACCAGCATGTCATCCACTTTG +candidate_22488840 pos=16:40123532-40123572 -48.277 -313.300 -0.855 40.58 AAAACAACAAACTTCGCTTAGGTGTCCTAAGCAAATGATT +candidate_22489854 pos=16:15135210-15135250 -48.073 -307.700 -0.837 41.29 AAAACAACAAAGAGGGCATATTCTGAGGAGATTTGGGAAT +candidate_22490642 pos=16:96113584-96113624 -53.503 -321.100 -0.863 46.43 AAAACAACAAAGCTTCATCCAGCATCCACAGCACCAGCAC +candidate_22491482 pos=16:97160493-97160533 -51.489 -319.800 -0.865 43.90 AAAACAACAAAGTGCTGATCAAAAGCAGAAACACGGGGTC +candidate_22494369 pos=16:15155435-15155475 -48.597 -312.100 -0.850 41.17 AAAACAACAAATTCTGCCATGCTTAGGGTTACAAATTGCT +candidate_22501160 pos=16:45181676-45181716 -48.655 -312.500 -0.851 41.18 AAAACAACAACAAAACCCACACAATGGATGTGATGAGTTT +candidate_22510637 pos=16:90188453-90188493 -47.184 -312.300 -0.855 39.36 AAAACAACAACAACAAACTCAGCTAGCTCCCATTAATAAG +candidate_22513714 pos=16:92173690-92173730 -52.779 -315.600 -0.847 46.34 AAAACAACAACAACAACAAAACCCCAAGTCCCCAGCACCA +candidate_22516171 pos=16:94158568-94158608 -48.360 -313.600 -0.855 40.74 AAAACAACAACAACAACAACAAAATACTGGTCCTCTCCTC +candidate_22518786 pos=16:94100674-94100714 -49.844 -318.000 -0.865 41.92 AAAACAACAACAACAACAACAACAACCATGTTCTGCATCC +candidate_22518902 pos=16:75105564-75105604 -48.158 -315.600 -0.862 40.09 AAAACAACAACAACAACAACAACAATCTCAGTGCATATCC +candidate_22519056 pos=16:94128515-94128555 -50.305 -316.600 -0.859 42.82 AAAACAACAACAACAACAACAACATCATTACTGTGGGCCC +candidate_22519488 pos=16:80166974-80167014 -48.814 -313.000 -0.852 41.41 AAAACAACAACAACAACAACACCTCTGTGATTACTGGAGA +candidate_22519521 pos=16:32145524-32145564 -49.956 -314.700 -0.854 42.58 AAAACAACAACAACAACAACAGAAAGAAACTGGGCATGGT +candidate_22519965 pos=16:96109738-96109778 -48.826 -315.400 -0.859 41.05 AAAACAACAACAACAACAAGAAGCTACTGATTATGGTGGC +candidate_22520899 pos=16:38131343-38131383 -51.168 -318.300 -0.861 43.74 AAAACAACAACAACAACCAGTCCAGTGCAGAGACCAAAAC +candidate_22522157 pos=16:6119212-6119252 -48.439 -313.400 -0.854 40.77 AAAACAACAACAACACCTGTTGTAAATAGACACAAGGCAA +candidate_22522176 pos=16:75109734-75109774 -49.306 -316.500 -0.862 41.48 AAAACAACAACAACACTCCAAAACAAACTGGAGAAGCAAG +candidate_22523023 pos=16:35115313-35115353 -48.790 -313.100 -0.852 41.26 AAAACAACAACAACCAAACCTACAAGAACAACAAAGGCAT +candidate_22525042 pos=16:9111319-9111359 -52.976 -322.000 -0.867 45.40 AAAACAACAACAATAACAGCAACAGCAGCAGCAGCAGCAA +candidate_22526849 pos=16:12172836-12172876 -52.852 -317.100 -0.852 46.28 AAAACAACAACAGACACACACAGCTGTGGTAGGGTAGCCA +candidate_22528041 pos=16:23191959-23191999 -53.508 -319.400 -0.857 46.72 AAAACAACAACAGTACATTCCCTGCCGTGGCCGATGAACT +candidate_22528622 pos=16:17193799-17193839 -54.549 -319.200 -0.853 48.30 AAAACAACAACATCAGCACTGGCTGCTCTTCCAGGGGACC +candidate_22530271 pos=16:42145836-42145876 -46.971 -307.900 -0.841 39.75 AAAACAACAACCATAAACTACCCTAGACATGGCTTTAAGT +candidate_22530532 pos=16:8117580-8117620 -49.945 -314.100 -0.852 42.87 AAAACAACAACCCACTTTGGGTCTATCTCTGTCAATGCTC +candidate_22530904 pos=16:58147083-58147123 -53.263 -319.000 -0.857 46.58 AAAACAACAACCGTAAGAAGGAGGCTGGAGGCTGATGCTC +candidate_22532719 pos=16:70126324-70126364 -51.199 -318.300 -0.861 43.67 AAAACAACAACTGGCAACAAACAAACGCTTGAGAGGATGT +candidate_22534710 pos=16:91136208-91136248 -46.426 -307.200 -0.841 39.16 AAAACAACAAGACTATAGGGGACATCTCATTCAAACACTA +candidate_22535706 pos=16:85174980-85175020 -53.894 -318.700 -0.854 47.34 AAAACAACAAGCAGTTTCTGCCACTGCCCAGTTCCTGCTT +candidate_22536165 pos=16:55102898-55102938 -52.160 -317.400 -0.855 45.24 AAAACAACAAGCTGTTCACATTTCTCTCCTGGGCGCTACT +candidate_22540553 pos=16:12181858-12181898 -48.458 -311.000 -0.847 41.37 AAAACAACAATAGTATGCTCTAACCAACCCATGACTTCCC +candidate_22540990 pos=16:41118273-41118313 -46.667 -307.100 -0.840 39.49 AAAACAACAATATCAACTAACTGGACACCTCAGGGATTAA +candidate_22542201 pos=16:38187412-38187452 -52.404 -316.900 -0.853 45.74 AAAACAACAATCTAGCCAGCTGGCCTGAGAAAAGTGGGTG +candidate_22543874 pos=16:63183017-63183057 -49.146 -314.200 -0.855 41.64 AAAACAACAATGTTGAAAGAAGCCAATATTTGCAGGGGTG +candidate_22544870 pos=16:53130099-53130139 -49.510 -312.300 -0.847 42.60 AAAACAACAATTTCAACTAACCAGACTCCCTGTCCCAGAG +candidate_22547933 pos=16:27108597-27108637 -54.031 -312.200 -0.832 49.00 AAAACAACACAAGTGGGGAGGGAGGGAGGGATTTGGGAGG +candidate_22548148 pos=16:60142430-60142470 -49.897 -314.300 -0.853 42.67 AAAACAACACAATCAGGTCTGTCACAGCAACACTCCATAA +candidate_22548235 pos=16:12159703-12159743 -47.821 -311.200 -0.849 40.33 AAAACAACACAATGAGACAGAGAAGCCTGGATTTTAACAA +candidate_22548621 pos=16:12161010-12161050 -47.124 -311.000 -0.851 39.48 AAAACAACACACAACTCCACAATACAAGAACTACACTAGA +candidate_22550604 pos=16:61104641-61104681 -50.454 -317.400 -0.861 42.98 AAAACAACACAGAGATACACACACATGCATGTACCCACAC +candidate_22551772 pos=16:62190688-62190728 -50.358 -312.900 -0.846 43.59 AAAACAACACAGTCAGGTCTGTGACAGCAATACCCCATTA +candidate_22553460 pos=16:30124149-30124189 -52.152 -316.400 -0.852 45.40 AAAACAACACATTTCAGGCTGTGTCTTGCCCAGAGTGACT +candidate_22554080 pos=16:22145308-22145348 -53.100 -316.200 -0.848 46.76 AAAACAACACCAAGGTCATGGAAGGCAGCTGGTGACATCA +candidate_22556001 pos=16:97101262-97101302 -50.796 -319.200 -0.865 43.13 AAAACAACACCGTGACACTCTTGCCTCACATTCTACAAAC +candidate_22556004 pos=16:91190766-91190806 -51.737 -318.900 -0.861 44.46 AAAACAACACCGTGGCCCAGCTAATTAGAACACACACTTC +candidate_22556430 pos=16:4139209-4139249 -51.436 -317.700 -0.859 44.17 AAAACAACACCTGCTCTAGACTGCAGCAACACAAACTGAA +candidate_22557039 pos=16:7141448-7141488 -53.319 -324.700 -0.875 45.39 AAAACAACACGCGGCTCCGTGAACACAATTGCATTGAAAA +candidate_22559472 pos=16:47180265-47180305 -49.963 -314.800 -0.854 42.78 AAAACAACACTGAGATTCCACCTCACAACAGTCAGAATGG +candidate_22559612 pos=16:77145310-77145350 -48.207 -311.400 -0.849 40.98 AAAACAACACTGAGATTCCATCTTAGACCTGTCAGAATGG +candidate_22560242 pos=16:37102570-37102610 -45.875 -308.200 -0.846 38.32 AAAACAACACTGGGGAAAAGAGTCTCATTATTATACTCTG +candidate_22560764 pos=16:57137711-57137751 -47.876 -311.100 -0.849 40.41 AAAACAACACTTAGCAGGTTTCATTGACATAGGCTTTCAT +candidate_22562354 pos=16:72178247-72178287 -48.791 -314.000 -0.855 41.12 AAAACAACAGAAAATGAGTGAGTTGTTTGAAGGCAGCATT +candidate_22563296 pos=16:87145435-87145475 -51.121 -314.500 -0.849 44.30 AAAACAACAGAAAGCCCACATACACATGGAAGCTGACCAA +candidate_22563325 pos=16:15143614-15143654 -50.229 -315.500 -0.855 42.90 AAAACAACAGAAAGCCCACATACACGAGGAAACTGAACAA diff --git a/test_data/test_db/chr16.bin b/test_data/test_db/chr16.bin new file mode 100644 index 0000000000000000000000000000000000000000..4a510b146f9c90e27107a8414665b6e6cf4e0567 GIT binary patch literal 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