diff --git a/docs/reference-manual/java-on-truffle/README.md b/docs/reference-manual/java-on-truffle/README.md
index f38c9e39faac..8419c55d1df8 100644
--- a/docs/reference-manual/java-on-truffle/README.md
+++ b/docs/reference-manual/java-on-truffle/README.md
@@ -52,7 +52,8 @@ You can download a standalone based on Oracle GraalVM or GraalVM Community Editi
    
 3. A standalone comes with a JVM in addition to its native launcher. Check the version to see the Java on Truffle runtime is active:
     ```shell
-    ./path/to/bin/java -truffle --version
+    # Path to Java on Truffle (Espresso) installation
+    ./path/to/bin/java -truffle -version
     ```
 
 ## Run Java on Truffle
@@ -99,7 +100,8 @@ This might be important for options such as `MaxDirectMemorySize` which can be s
 
 To ensure you have successfully installed Java on Truffle, verify its version:
 ```shell
-java -truffle -version
+# Path to Java on Truffle (Espresso) installation
+./path/to/bin/java -truffle -version
 ```
 
 Taking this `HelloWorld.java` example, compile it and run from the command line:
diff --git a/substratevm/src/com.oracle.graal.pointsto/src/com/oracle/graal/pointsto/flow/MethodTypeFlowBuilder.java b/substratevm/src/com.oracle.graal.pointsto/src/com/oracle/graal/pointsto/flow/MethodTypeFlowBuilder.java
index 9a1f417ee7d6..83b6e3f201ce 100644
--- a/substratevm/src/com.oracle.graal.pointsto/src/com/oracle/graal/pointsto/flow/MethodTypeFlowBuilder.java
+++ b/substratevm/src/com.oracle.graal.pointsto/src/com/oracle/graal/pointsto/flow/MethodTypeFlowBuilder.java
@@ -1474,7 +1474,7 @@ protected void processMethodInvocation(TypeFlowsOfNodes state, Invoke invoke, In
     }
 
     /* Get a reasonable position for inlined invokes, avoiding cycles in the parsing backtrace. */
-    private BytecodePosition getInvokePosition(FixedNode invokeNode) {
+    protected BytecodePosition getInvokePosition(FixedNode invokeNode) {
         BytecodePosition invokePosition = invokeNode.getNodeSourcePosition();
         /* Get the outermost caller position for inlined invokes. */
         while (invokePosition != null && invokePosition.getCaller() != null) {
diff --git a/substratevm/src/com.oracle.graal.pointsto/src/com/oracle/graal/pointsto/meta/AnalysisMethod.java b/substratevm/src/com.oracle.graal.pointsto/src/com/oracle/graal/pointsto/meta/AnalysisMethod.java
index 64c5ea8d67cb..a6c8c1a6b857 100644
--- a/substratevm/src/com.oracle.graal.pointsto/src/com/oracle/graal/pointsto/meta/AnalysisMethod.java
+++ b/substratevm/src/com.oracle.graal.pointsto/src/com/oracle/graal/pointsto/meta/AnalysisMethod.java
@@ -927,11 +927,19 @@ private void waitOnLock(ReentrantLock lock) {
         }
     }
 
+    public StructuredGraph decodeAnalyzedGraph(DebugContext debug, Iterable<EncodedNodeReference> nodeReferences) {
+        if (analyzedGraph == null) {
+            return null;
+        }
+
+        return decodeAnalyzedGraph(debug, nodeReferences, analyzedGraph.trackNodeSourcePosition());
+    }
+
     /**
      * Returns the {@link StructuredGraph Graal IR} for the method that has been processed by the
      * static analysis.
      */
-    public StructuredGraph decodeAnalyzedGraph(DebugContext debug, Iterable<EncodedNodeReference> nodeReferences) {
+    public StructuredGraph decodeAnalyzedGraph(DebugContext debug, Iterable<EncodedNodeReference> nodeReferences, boolean trackNodeSourcePosition) {
         if (analyzedGraph == null) {
             return null;
         }
@@ -939,7 +947,7 @@ public StructuredGraph decodeAnalyzedGraph(DebugContext debug, Iterable<EncodedN
         var allowAssumptions = getUniverse().hostVM().allowAssumptions(this);
         // Note we never record inlined methods. This is correct even for runtime compiled methods
         StructuredGraph result = new StructuredGraph.Builder(debug.getOptions(), debug, allowAssumptions).method(this).recordInlinedMethods(false).trackNodeSourcePosition(
-                        analyzedGraph.trackNodeSourcePosition()).build();
+                        trackNodeSourcePosition).build();
         GraphDecoder decoder = new GraphDecoder(AnalysisParsedGraph.HOST_ARCHITECTURE, result);
         decoder.decode(analyzedGraph, nodeReferences);
         /*
diff --git a/substratevm/src/com.oracle.graal.pointsto/src/com/oracle/graal/pointsto/phases/InlineBeforeAnalysisGraphDecoder.java b/substratevm/src/com.oracle.graal.pointsto/src/com/oracle/graal/pointsto/phases/InlineBeforeAnalysisGraphDecoder.java
index da5c18c0eda3..9f20e9abf617 100644
--- a/substratevm/src/com.oracle.graal.pointsto/src/com/oracle/graal/pointsto/phases/InlineBeforeAnalysisGraphDecoder.java
+++ b/substratevm/src/com.oracle.graal.pointsto/src/com/oracle/graal/pointsto/phases/InlineBeforeAnalysisGraphDecoder.java
@@ -502,6 +502,7 @@ protected InlineBeforeAnalysisMethodScope cast(MethodScope methodScope) {
     @Override
     protected FixedWithNextNode afterMethodScopeCreation(PEMethodScope is, FixedWithNextNode predecessor) {
         InlineBeforeAnalysisMethodScope inlineScope = cast(is);
-        return policy.processInvokeArgs(inlineScope.method, predecessor, inlineScope.getArguments());
+        var sourcePosition = inlineScope.invokeData.invoke.asNode().getNodeSourcePosition();
+        return policy.processInvokeArgs(inlineScope.method, predecessor, inlineScope.getArguments(), sourcePosition);
     }
 }
diff --git a/substratevm/src/com.oracle.graal.pointsto/src/com/oracle/graal/pointsto/phases/InlineBeforeAnalysisPolicy.java b/substratevm/src/com.oracle.graal.pointsto/src/com/oracle/graal/pointsto/phases/InlineBeforeAnalysisPolicy.java
index 34ba7a30e96b..cf1d12204159 100644
--- a/substratevm/src/com.oracle.graal.pointsto/src/com/oracle/graal/pointsto/phases/InlineBeforeAnalysisPolicy.java
+++ b/substratevm/src/com.oracle.graal.pointsto/src/com/oracle/graal/pointsto/phases/InlineBeforeAnalysisPolicy.java
@@ -25,6 +25,7 @@
 package com.oracle.graal.pointsto.phases;
 
 import org.graalvm.compiler.graph.Node;
+import org.graalvm.compiler.graph.NodeSourcePosition;
 import org.graalvm.compiler.nodes.FixedWithNextNode;
 import org.graalvm.compiler.nodes.ValueNode;
 import org.graalvm.compiler.nodes.graphbuilderconf.GraphBuilderContext;
@@ -93,7 +94,7 @@ protected InlineBeforeAnalysisPolicy(NodePlugin[] nodePlugins) {
 
     protected abstract boolean tryInvocationPlugins();
 
-    protected abstract FixedWithNextNode processInvokeArgs(ResolvedJavaMethod targetMethod, FixedWithNextNode insertionPoint, ValueNode[] arguments);
+    protected abstract FixedWithNextNode processInvokeArgs(ResolvedJavaMethod targetMethod, FixedWithNextNode insertionPoint, ValueNode[] arguments, NodeSourcePosition sourcePosition);
 
     protected abstract AbstractPolicyScope createRootScope();
 
@@ -132,7 +133,7 @@ protected boolean tryInvocationPlugins() {
         }
 
         @Override
-        protected FixedWithNextNode processInvokeArgs(ResolvedJavaMethod targetMethod, FixedWithNextNode insertionPoint, ValueNode[] arguments) {
+        protected FixedWithNextNode processInvokeArgs(ResolvedJavaMethod targetMethod, FixedWithNextNode insertionPoint, ValueNode[] arguments, NodeSourcePosition sourcePosition) {
             throw AnalysisError.shouldNotReachHere("NO_INLINING policy should not try to inline");
         }
 
diff --git a/substratevm/src/com.oracle.svm.core/src/com/oracle/svm/core/graal/replacements/SubstrateGraphKit.java b/substratevm/src/com.oracle.svm.core/src/com/oracle/svm/core/graal/replacements/SubstrateGraphKit.java
index 5a9473748364..1345aab3d7d8 100644
--- a/substratevm/src/com.oracle.svm.core/src/com/oracle/svm/core/graal/replacements/SubstrateGraphKit.java
+++ b/substratevm/src/com.oracle.svm.core/src/com/oracle/svm/core/graal/replacements/SubstrateGraphKit.java
@@ -100,9 +100,8 @@ public class SubstrateGraphKit extends GraphKit {
     private final FrameStateBuilder frameState;
     private int nextBCI;
 
-    // For GR-45916 this should be unconditionally true when parseOnce is enabled.
     private static boolean trackNodeSourcePosition(boolean forceTrackNodeSourcePosition) {
-        return forceTrackNodeSourcePosition || (SubstrateOptions.parseOnce() && !SubstrateOptions.ParseOnceJIT.getValue());
+        return forceTrackNodeSourcePosition || SubstrateOptions.parseOnce();
     }
 
     @SuppressWarnings("this-escape")
diff --git a/substratevm/src/com.oracle.svm.graal/src/com/oracle/svm/graal/hosted/ParseOnceRuntimeCompilationFeature.java b/substratevm/src/com.oracle.svm.graal/src/com/oracle/svm/graal/hosted/ParseOnceRuntimeCompilationFeature.java
index 2474c4128a5f..cfe05e20099c 100644
--- a/substratevm/src/com.oracle.svm.graal/src/com/oracle/svm/graal/hosted/ParseOnceRuntimeCompilationFeature.java
+++ b/substratevm/src/com.oracle.svm.graal/src/com/oracle/svm/graal/hosted/ParseOnceRuntimeCompilationFeature.java
@@ -53,6 +53,7 @@
 import org.graalvm.compiler.debug.DebugHandlersFactory;
 import org.graalvm.compiler.debug.Indent;
 import org.graalvm.compiler.graph.NodeClass;
+import org.graalvm.compiler.graph.NodeSourcePosition;
 import org.graalvm.compiler.java.BytecodeParser;
 import org.graalvm.compiler.java.GraphBuilderPhase;
 import org.graalvm.compiler.loop.phases.ConvertDeoptimizeToGuardPhase;
@@ -569,7 +570,7 @@ private void compileRuntimeCompiledMethod(DebugContext debug, HostedMethod metho
         assert method.getMultiMethodKey() == RUNTIME_COMPILED_METHOD;
 
         AnalysisMethod aMethod = method.getWrapped();
-        StructuredGraph graph = aMethod.decodeAnalyzedGraph(debug, null);
+        StructuredGraph graph = aMethod.decodeAnalyzedGraph(debug, null, false);
         if (graph == null) {
             throw VMError.shouldNotReachHere("Method not parsed during static analysis: " + aMethod.format("%r %H.%n(%p)"));
         }
@@ -1021,9 +1022,10 @@ protected boolean needsExplicitExceptions() {
         }
 
         @Override
-        protected FixedWithNextNode processInvokeArgs(ResolvedJavaMethod targetMethod, FixedWithNextNode insertionPoint, ValueNode[] arguments) {
+        protected FixedWithNextNode processInvokeArgs(ResolvedJavaMethod targetMethod, FixedWithNextNode insertionPoint, ValueNode[] arguments, NodeSourcePosition sourcePosition) {
             StructuredGraph graph = insertionPoint.graph();
             InlinedInvokeArgumentsNode newNode = graph.add(new InlinedInvokeArgumentsNode(targetMethod, arguments));
+            newNode.setNodeSourcePosition(sourcePosition);
             graph.addAfterFixed(insertionPoint, newNode);
             return newNode;
         }
diff --git a/substratevm/src/com.oracle.svm.graal/src/com/oracle/svm/graal/hosted/RuntimeCompilationFeature.java b/substratevm/src/com.oracle.svm.graal/src/com/oracle/svm/graal/hosted/RuntimeCompilationFeature.java
index 2676179589f2..6eb6a9b4db28 100644
--- a/substratevm/src/com.oracle.svm.graal/src/com/oracle/svm/graal/hosted/RuntimeCompilationFeature.java
+++ b/substratevm/src/com.oracle.svm.graal/src/com/oracle/svm/graal/hosted/RuntimeCompilationFeature.java
@@ -527,7 +527,7 @@ public void initializeRuntimeCompilationConfiguration(HostedProviders newHostedP
         runtimeCompilationCandidatePredicateUpdated = true;
         deoptimizeOnExceptionPredicate = newDeoptimizeOnExceptionPredicate;
 
-        if (SubstrateOptions.IncludeNodeSourcePositions.getValue()) {
+        if (SubstrateOptions.IncludeNodeSourcePositions.getValue() || SubstrateOptions.parseOnce()) {
             graphBuilderConfig = graphBuilderConfig.withNodeSourcePosition(true);
         }
     }
diff --git a/substratevm/src/com.oracle.svm.hosted/src/com/oracle/svm/hosted/analysis/flow/SVMMethodTypeFlowBuilder.java b/substratevm/src/com.oracle.svm.hosted/src/com/oracle/svm/hosted/analysis/flow/SVMMethodTypeFlowBuilder.java
index 761f6d045330..053139a10d37 100644
--- a/substratevm/src/com.oracle.svm.hosted/src/com/oracle/svm/hosted/analysis/flow/SVMMethodTypeFlowBuilder.java
+++ b/substratevm/src/com.oracle.svm.hosted/src/com/oracle/svm/hosted/analysis/flow/SVMMethodTypeFlowBuilder.java
@@ -214,9 +214,7 @@ private void processInlinedInvokeArgumentsNode(TypeFlowsOfNodes state, InlinedIn
          * Create a proxy invoke type flow for the inlined method.
          */
         PointsToAnalysisMethod targetMethod = (PointsToAnalysisMethod) node.getInvokeTarget();
-        // GR-45916 add proper source position information.
-        BytecodePosition position = AbstractAnalysisEngine.syntheticSourcePosition(node, method);
         InvokeKind invokeKind = targetMethod.isStatic() ? InvokeKind.Static : InvokeKind.Special;
-        processMethodInvocation(state, node, invokeKind, targetMethod, node.getArguments(), true, position, true);
+        processMethodInvocation(state, node, invokeKind, targetMethod, node.getArguments(), true, getInvokePosition(node), true);
     }
 }
diff --git a/substratevm/src/com.oracle.svm.hosted/src/com/oracle/svm/hosted/classinitialization/SimulateClassInitializerPolicy.java b/substratevm/src/com.oracle.svm.hosted/src/com/oracle/svm/hosted/classinitialization/SimulateClassInitializerPolicy.java
index 9b02563fdcd9..652efb568bbc 100644
--- a/substratevm/src/com.oracle.svm.hosted/src/com/oracle/svm/hosted/classinitialization/SimulateClassInitializerPolicy.java
+++ b/substratevm/src/com.oracle.svm.hosted/src/com/oracle/svm/hosted/classinitialization/SimulateClassInitializerPolicy.java
@@ -25,6 +25,7 @@
 package com.oracle.svm.hosted.classinitialization;
 
 import org.graalvm.compiler.graph.Node;
+import org.graalvm.compiler.graph.NodeSourcePosition;
 import org.graalvm.compiler.nodes.FixedWithNextNode;
 import org.graalvm.compiler.nodes.ValueNode;
 import org.graalvm.compiler.nodes.graphbuilderconf.GraphBuilderContext;
@@ -139,7 +140,7 @@ protected InlineInvokePlugin.InlineInfo createInvokeInfo(ResolvedJavaMethod meth
     }
 
     @Override
-    protected FixedWithNextNode processInvokeArgs(ResolvedJavaMethod targetMethod, FixedWithNextNode insertionPoint, ValueNode[] arguments) {
+    protected FixedWithNextNode processInvokeArgs(ResolvedJavaMethod targetMethod, FixedWithNextNode insertionPoint, ValueNode[] arguments, NodeSourcePosition sourcePosition) {
         // No action is needed
         return insertionPoint;
     }
diff --git a/substratevm/src/com.oracle.svm.hosted/src/com/oracle/svm/hosted/phases/InlineBeforeAnalysisPolicyImpl.java b/substratevm/src/com.oracle.svm.hosted/src/com/oracle/svm/hosted/phases/InlineBeforeAnalysisPolicyImpl.java
index b132838fe87e..877490c2e1d7 100644
--- a/substratevm/src/com.oracle.svm.hosted/src/com/oracle/svm/hosted/phases/InlineBeforeAnalysisPolicyImpl.java
+++ b/substratevm/src/com.oracle.svm.hosted/src/com/oracle/svm/hosted/phases/InlineBeforeAnalysisPolicyImpl.java
@@ -24,6 +24,7 @@
  */
 package com.oracle.svm.hosted.phases;
 
+import org.graalvm.compiler.graph.NodeSourcePosition;
 import org.graalvm.compiler.nodes.FixedWithNextNode;
 import org.graalvm.compiler.nodes.ValueNode;
 import org.graalvm.compiler.nodes.graphbuilderconf.GraphBuilderContext;
@@ -117,7 +118,7 @@ protected boolean shouldOmitIntermediateMethodInState(ResolvedJavaMethod method)
     }
 
     @Override
-    protected FixedWithNextNode processInvokeArgs(ResolvedJavaMethod targetMethod, FixedWithNextNode insertionPoint, ValueNode[] arguments) {
+    protected FixedWithNextNode processInvokeArgs(ResolvedJavaMethod targetMethod, FixedWithNextNode insertionPoint, ValueNode[] arguments, NodeSourcePosition sourcePosition) {
         // No action is needed
         return insertionPoint;
     }