diff --git a/src/lib/spinel/CMakeLists.txt b/src/lib/spinel/CMakeLists.txt
index de68fc25a6a..e6cf16f58fd 100644
--- a/src/lib/spinel/CMakeLists.txt
+++ b/src/lib/spinel/CMakeLists.txt
@@ -26,27 +26,22 @@
 #  POSSIBILITY OF SUCH DAMAGE.
 #
 
+add_library(openthread-radio-spinel)
 add_library(openthread-spinel-ncp)
 add_library(openthread-spinel-rcp)
 
 target_compile_definitions(openthread-spinel-ncp PRIVATE
-    OPENTHREAD_FTD=1
     PUBLIC OPENTHREAD_SPINEL_CONFIG_OPENTHREAD_MESSAGE_ENABLE=1
 )
 
-if (OT_NCP_SPI)
-    target_compile_definitions(openthread-spinel-ncp PRIVATE OPENTHREAD_CONFIG_NCP_HDLC_ENABLE=0)
-    target_compile_definitions(openthread-spinel-rcp PRIVATE OPENTHREAD_CONFIG_NCP_HDLC_ENABLE=0)
-else()
-    target_compile_definitions(openthread-spinel-ncp PRIVATE OPENTHREAD_CONFIG_NCP_HDLC_ENABLE=1)
-    target_compile_definitions(openthread-spinel-rcp PRIVATE OPENTHREAD_CONFIG_NCP_HDLC_ENABLE=1)
-endif()
-
 target_compile_definitions(openthread-spinel-rcp PRIVATE
-    OPENTHREAD_RADIO=1
     PUBLIC OPENTHREAD_SPINEL_CONFIG_OPENTHREAD_MESSAGE_ENABLE=0
 )
 
+target_compile_options(openthread-radio-spinel PRIVATE
+    ${OT_CFLAGS}
+)
+
 target_compile_options(openthread-spinel-ncp PRIVATE
     ${OT_CFLAGS}
 )
@@ -61,19 +56,25 @@ set(COMMON_INCLUDES
 )
 
 set(COMMON_SOURCES
-    radio_spinel.cpp
     spinel.c
     spinel_buffer.cpp
     spinel_decoder.cpp
     spinel_encoder.cpp
 )
 
+target_include_directories(openthread-radio-spinel PUBLIC ${OT_PUBLIC_INCLUDES} PRIVATE ${COMMON_INCLUDES})
 target_include_directories(openthread-spinel-ncp PUBLIC ${OT_PUBLIC_INCLUDES} PRIVATE ${COMMON_INCLUDES})
 target_include_directories(openthread-spinel-rcp PUBLIC ${OT_PUBLIC_INCLUDES} PRIVATE ${COMMON_INCLUDES})
 
+target_sources(openthread-radio-spinel PRIVATE radio_spinel.cpp)
 target_sources(openthread-spinel-ncp PRIVATE ${COMMON_SOURCES})
 target_sources(openthread-spinel-rcp PRIVATE ${COMMON_SOURCES})
 
+target_link_libraries(openthread-radio-spinel
+    PRIVATE
+        ot-config
+)
+
 target_link_libraries(openthread-spinel-ncp
     PRIVATE
         ot-config-ftd
diff --git a/src/posix/cli.cmake b/src/posix/cli.cmake
index 4b7347b4039..a11ef0b8545 100644
--- a/src/posix/cli.cmake
+++ b/src/posix/cli.cmake
@@ -50,6 +50,7 @@ target_link_libraries(ot-cli PRIVATE
     openthread-posix
     openthread-cli-ftd
     openthread-hdlc
+    openthread-radio-spinel
     openthread-spinel-rcp
     ${OT_MBEDTLS}
     ${READLINE_LINK_LIBRARIES}
diff --git a/src/posix/daemon.cmake b/src/posix/daemon.cmake
index dd726df27b7..dd19a22806a 100644
--- a/src/posix/daemon.cmake
+++ b/src/posix/daemon.cmake
@@ -42,6 +42,7 @@ target_link_libraries(ot-daemon PRIVATE
     openthread-ftd
     openthread-posix
     openthread-hdlc
+    openthread-radio-spinel
     openthread-spinel-rcp
     ${OT_MBEDTLS}
     ot-posix-config
diff --git a/src/posix/platform/CMakeLists.txt b/src/posix/platform/CMakeLists.txt
index b367d8758d6..dfc62408eba 100644
--- a/src/posix/platform/CMakeLists.txt
+++ b/src/posix/platform/CMakeLists.txt
@@ -154,6 +154,7 @@ target_link_libraries(openthread-posix
         openthread-cli-ftd
         openthread-ftd
         openthread-hdlc
+        openthread-radio-spinel
         openthread-spinel-rcp
         openthread-url
         ot-config-ftd