diff --git a/sycl/test-e2e/Regression/multiple-targets.cpp b/sycl/test-e2e/Regression/multiple-targets.cpp
index 13f136f8aa64a..d21f7c458aec2 100644
--- a/sycl/test-e2e/Regression/multiple-targets.cpp
+++ b/sycl/test-e2e/Regression/multiple-targets.cpp
@@ -2,17 +2,17 @@
 // It tests if the target triples can be specified with any order.
 // The test is repeated for per_kernel device code splitting.
 //
-// REQUIRES: CUDA || HIP
-// RUN: %clangxx -fsycl -fsycl-targets=%{sycl_triple},spirv64 -o %t.out %s
+// REQUIRES: cuda || hip || native_cpu
+// RUN: %clangxx -fsycl -fsycl-targets=%{sycl_triple},spir64 -o %t.out %s
 // RUN: %{run} %t.out
 //
-// RUN: %clangxx -fsycl -fsycl-targets=spirv64,%{sycl_triple} -o %t.out %s
+// RUN: %clangxx -fsycl -fsycl-targets=spir64,%{sycl_triple} -o %t.out %s
 // RUN: %{run} %t.out
 //
-// RUN: %clangxx -fsycl -fsycl-targets=%{sycl_triple},spirv64 -fsycl-device-code-split=per_kernel -o %t.out %s
+// RUN: %clangxx -fsycl -fsycl-targets=%{sycl_triple},spir64 -fsycl-device-code-split=per_kernel -o %t.out %s
 // RUN: %{run} %t.out
 //
-// RUN: %clangxx -fsycl -fsycl-targets=spirv64,%{sycl_triple} -fsycl-device-code-split=per_kernel -o %t.out %s
+// RUN: %clangxx -fsycl -fsycl-targets=spir64,%{sycl_triple} -fsycl-device-code-split=per_kernel -o %t.out %s
 // RUN: %{run} %t.out
 //
 // XFAIL: hip_nvidia