diff --git a/jax/_src/cache_key.py b/jax/_src/cache_key.py
index 6fdf0c600b7d..9bce9d0e4308 100644
--- a/jax/_src/cache_key.py
+++ b/jax/_src/cache_key.py
@@ -83,7 +83,8 @@ def get(module: ir.Module,
    'jit__psum-14ac577cdb2ef6d986078b4054cc9893a9a14a16dbb0d8f37b89167c1f1aacdf'
   """
   entries = [
-      ("computation", lambda hash_obj: _hash_computation(hash_obj, module)),
+      ("computation",
+       lambda hash_obj: _hash_computation(hash_obj, module)),
       ("jax_lib version",
        lambda hash_obj: hash_obj.update(
            bytes(jaxlib_version_str.encode("utf-8")))),
@@ -129,8 +130,26 @@ def _log_cache_key_hash(hash_obj, last_serialized: str, hashfn):
     )
 
 
+def _remove_custom_partitioning_ptr(m: ir.Module):
+  """
+  Removes custom_partitioning callback pointer from precompiled IR.
+  Python function pointers are not deterministic across executions.
+  """
+  def _update_bc_attribute(op: ir.Operation) -> ir.WalkResult:
+    if (op.name == "stablehlo.custom_call" and
+        op.attributes["call_target_name"].value == "CustomSPMDPartitioning"):
+      op.attributes["backend_config"] = ir.StringAttr.get("REMOVED")
+    return ir.WalkResult.ADVANCE
+
+  m.operation.walk(_update_bc_attribute)
+  return m
+
+
 def _serialize_ir(m: ir.Module) -> bytes:
   output = io.BytesIO()
+  if config.remove_custom_partitioning_ptr_from_cache_key.value:
+    m = _remove_custom_partitioning_ptr(type_cast(ir.Module,
+                                                  m.operation.clone()))
   m.operation.write_bytecode(file=output)
   return output.getvalue()
 
diff --git a/jax/_src/compilation_cache.py b/jax/_src/compilation_cache.py
index 8117f871a969..b946dc0a2897 100644
--- a/jax/_src/compilation_cache.py
+++ b/jax/_src/compilation_cache.py
@@ -265,7 +265,9 @@ def put_executable_and_time(
     cache.put(cache_key, executable_and_time)
 
 
-def get_cache_key(module: ir.Module, devices: np.ndarray, compile_options,
+def get_cache_key(module: ir.Module,
+                  devices: np.ndarray,
+                  compile_options,
                   backend) -> str:
   return cache_key.get(module, devices, compile_options, backend,
                        "zstandard" if zstandard is not None else "zlib")
diff --git a/jax/_src/config.py b/jax/_src/config.py
index b2d1aa52ef2a..51d7dab585af 100644
--- a/jax/_src/config.py
+++ b/jax/_src/config.py
@@ -1347,6 +1347,16 @@ def _update_jax_memories_thread_local(val):
           'size to grow indefinitely.'),
 )
 
+remove_custom_partitioning_ptr_from_cache_key = bool_state(
+    name='jax_remove_custom_partitioning_ptr_from_cache_key',
+    default=False,
+    help=('If set to True, remove the custom partitioning pointer '
+          'present in the precompiled stableHLO before hashing  '
+          'during cache key computation. This is a potentially '
+          'unsafe flag to set and only users who are sure of '
+          'what they are trying to achieve should set it.'),
+)
+
 default_dtype_bits = enum_state(
     name='jax_default_dtype_bits',
     enum_values=['32', '64'],
diff --git a/tests/cache_key_test.py b/tests/cache_key_test.py
index 508dbacc2a98..00925c5f7dfc 100644
--- a/tests/cache_key_test.py
+++ b/tests/cache_key_test.py
@@ -14,8 +14,10 @@
 
 import hashlib
 import os
+import re
 import sys
 import unittest
+from typing import cast as type_cast
 
 import numpy as np
 
@@ -29,6 +31,11 @@
 from jax._src import test_util as jtu
 from jax._src import xla_bridge
 from jax._src.lib import xla_client
+from jax._src.lib.mlir import ir
+from jax._src.mesh import Mesh
+from jax._src.partition_spec import PartitionSpec as P
+from jax._src.sharding_impls import NamedSharding
+from jax._src.custom_partitioning import custom_partitioning
 
 
 config.parse_flags_with_absl()
@@ -155,6 +162,49 @@ def test_different_computations(self):
         cache_key.get(computation2, devices, compile_options, backend),
     )
 
+  def test_custom_partitioning_ptr_removal(self):
+    def _partition(mesh, arg_shapes, result_shape):
+      arg_shardings = jax.tree.map(lambda x: x.sharding, arg_shapes)
+      result_shardings = NamedSharding(mesh, arg_shapes[0].sharding.spec)
+      return mesh, jax.numpy.add, result_shardings, arg_shardings
+
+    def _infer_sharding_from_operands(mesh, arg_shapes, result_shape):
+      return NamedSharding(mesh, arg_shapes[0].sharding.spec)
+
+    @custom_partitioning
+    def _cp_add(x, y):
+        return jax.numpy.add(x, y)
+
+    _cp_add.def_partition(
+      infer_sharding_from_operands=_infer_sharding_from_operands,
+      partition=_partition)
+
+    devices = np.asarray(jax.devices())
+    with Mesh(devices, ('x',)) as m:
+      computation = jax.jit(
+        _cp_add,
+        in_shardings=(NamedSharding(m, P('x')),
+                      NamedSharding(m, P('x'))),
+                      out_shardings=NamedSharding(m, P('x'))
+      ).lower(
+        jax.ShapeDtypeStruct([1024], dtype=jax.numpy.float32),
+        jax.ShapeDtypeStruct([1024], dtype=jax.numpy.float32),
+      ).compiler_ir()
+      pattern = (
+          r'stablehlo\.custom_call @CustomSPMDPartitioning\('
+          r'(.*?)\) \{'
+          r'(.*?backend_config\s*=\s*"([^"]*)".*?)'
+          r'\}'
+      )
+      with config.remove_custom_partitioning_ptr_from_cache_key(True):
+        with computation.context:
+          updated_module = cache_key._remove_custom_partitioning_ptr(
+            type_cast(ir.Module, computation.operation.clone()))
+          bcs = [match[2] for
+                 match in re.findall(pattern, str(updated_module), re.DOTALL)]
+          for bc in bcs:
+            self.assertEqual(bc, "REMOVED")
+
   def test_different_device_assignment(self):
     computation = jax.jit(lambda x, y: x + y).lower(1, 1).compiler_ir()
     devices = np.array([[jax.local_devices()[0]]])