diff --git a/docs/changes.rst b/docs/changes.rst
index 581a9fce1..85488250b 100644
--- a/docs/changes.rst
+++ b/docs/changes.rst
@@ -4,6 +4,7 @@ Change log
 Pending
 -------
 
+* Added Django 5.1 to the CI matrix.
 * Support select and explain buttons for ``UNION`` queries on PostgreSQL.
 * Fixed internal toolbar requests being instrumented if the Django setting
   ``FORCE_SCRIPT_NAME`` was set.
diff --git a/pyproject.toml b/pyproject.toml
index 451887d35..611015e13 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -19,6 +19,7 @@ classifiers = [
   "Framework :: Django",
   "Framework :: Django :: 4.2",
   "Framework :: Django :: 5.0",
+  "Framework :: Django :: 5.1",
   "Intended Audience :: Developers",
   "License :: OSI Approved :: BSD License",
   "Operating System :: OS Independent",
diff --git a/tox.ini b/tox.ini
index 160b33db7..1bba8d38f 100644
--- a/tox.ini
+++ b/tox.ini
@@ -4,12 +4,13 @@ envlist =
     docs
     packaging
     py{38,39,310,311,312}-dj{42}-{sqlite,postgresql,postgis,mysql}
-    py{310,311,312}-dj{42,50,main}-{sqlite,postgresql,psycopg3,postgis,mysql}
+    py{310,311,312}-dj{42,50,51,main}-{sqlite,postgresql,psycopg3,postgis,mysql}
 
 [testenv]
 deps =
     dj42: django~=4.2.1
     dj50: django~=5.0.2
+    dj51: django~=5.1.0
     djmain: https://github.com/django/django/archive/main.tar.gz
     postgresql: psycopg2-binary
     psycopg3: psycopg[binary]
@@ -48,28 +49,28 @@ pip_pre = True
 commands = python -b -W always -m coverage run -m django test -v2 {posargs:tests}
 
 
-[testenv:py{38,39,310,311,312}-dj{42,50,main}-{postgresql,psycopg3}]
+[testenv:py{38,39,310,311,312}-dj{42,50,51,main}-{postgresql,psycopg3}]
 setenv =
     {[testenv]setenv}
     DB_BACKEND = postgresql
     DB_PORT = {env:DB_PORT:5432}
 
 
-[testenv:py{38,39,310,311,312}-dj{42,50,main}-postgis]
+[testenv:py{38,39,310,311,312}-dj{42,50,51,main}-postgis]
 setenv =
     {[testenv]setenv}
     DB_BACKEND = postgis
     DB_PORT = {env:DB_PORT:5432}
 
 
-[testenv:py{38,39,310,311,312}-dj{42,50,main}-mysql]
+[testenv:py{38,39,310,311,312}-dj{42,50,51,main}-mysql]
 setenv =
     {[testenv]setenv}
     DB_BACKEND = mysql
     DB_PORT = {env:DB_PORT:3306}
 
 
-[testenv:py{38,39,310,311,312}-dj{42,50,main}-sqlite]
+[testenv:py{38,39,310,311,312}-dj{42,50,51,main}-sqlite]
 setenv =
     {[testenv]setenv}
     DB_BACKEND = sqlite3