diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index 57a2078..e36524b 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -12,43 +12,26 @@ jobs:
       fail-fast: false
       matrix:
         versions:
-          - python: 3.5
-            toxenv: py35-2.2.X
-          - python: 3.6
-            toxenv: py36-2.2.X
-          - python: 3.7
-            toxenv: py37-2.2.X
           - python: 3.8
-            toxenv: py38-2.2.X
-          - python: 3.9
-            toxenv: py39-2.2.X
-
-          - python: 3.6
-            toxenv: py36-3.0.X
-          - python: 3.7
-            toxenv: py37-3.0.X
+            toxenv: py38-3.2.X
           - python: 3.8
-            toxenv: py38-3.0.X
-          - python: 3.9
-            toxenv: py39-3.0.X
-
-          - python: 3.6
-            toxenv: py36-3.1.X
-          - python: 3.7
-            toxenv: py37-3.1.X
+            toxenv: py38-4.0.X
           - python: 3.8
-            toxenv: py38-3.1.X
-          - python: 3.9
-            toxenv: py39-3.1.X
-
-          - python: 3.6
-            toxenv: py36-3.2.X
-          - python: 3.7
-            toxenv: py37-3.2.X
-          - python: 3.8
-            toxenv: py38-3.2.X
+            toxenv: py38-4.2.X
+         
           - python: 3.9
             toxenv: py39-3.2.X
+          - python: 3.9
+            toxenv: py39-4.0.X
+          - python: 3.9
+            toxenv: py39-4.2.X
+        
+          - python: "3.10"
+            toxenv: py310-3.2.X
+          - python: "3.10"
+            toxenv: py310-4.0.X
+          - python: "3.10"
+            toxenv: py310-4.2.X
 
     runs-on: ubuntu-latest
     steps:
diff --git a/.travis.yml b/.travis.yml
deleted file mode 100644
index 7de3f76..0000000
--- a/.travis.yml
+++ /dev/null
@@ -1,64 +0,0 @@
-dist: xenial
-
-sudo: false
-
-language: python
-
-matrix:
-    include:
-      - python: 3.5
-        env: TOX_ENV=ppy35-2.2.X
-
-      - python: 3.6
-        env: TOX_ENV=ppy36-2.2.X
-
-      - python: 3.7
-        env: TOX_ENV=ppy37-2.2.X
-
-      - python: 3.8
-        env: TOX_ENV=ppy38-2.2.X
-
-      - python: 3.9
-        env: TOX_ENV=ppy39-2.2.X
-
-      - python: 3.6
-        env: TOX_ENV=ppy36-3.0.X
-
-      - python: 3.7
-        env: TOX_ENV=ppy37-3.0.X
-
-      - python: 3.8
-        env: TOX_ENV=ppy38-3.0.X
-
-      - python: 3.9
-        env: TOX_ENV=ppy39-3.0.X
-
-      - python: 3.6
-        env: TOX_ENV=ppy36-3.1.X
-
-      - python: 3.7
-        env: TOX_ENV=ppy37-3.1.X
-
-      - python: 3.8
-        env: TOX_ENV=ppy38-3.1.X
-
-      - python: 3.9
-        env: TOX_ENV=ppy39-3.1.X
-
-      - python: 3.6
-        env: TOX_ENV=ppy36-3.2.X
-
-      - python: 3.7
-        env: TOX_ENV=ppy37-3.2.X
-
-      - python: 3.8
-        env: TOX_ENV=ppy38-3.2.X
-
-      - python: 3.9
-        env: TOX_ENV=ppy39-3.2.X
-
-install:
-    - pip install tox
-
-script:
-    - tox -e $TOX_ENV
diff --git a/multidb/__init__.py b/multidb/__init__.py
index 9541e80..5ac3bdd 100644
--- a/multidb/__init__.py
+++ b/multidb/__init__.py
@@ -139,8 +139,8 @@ class PinningReplicaRouter(ReplicaRouter):
 
     """
     def db_for_read(self, model, **hints):
-        """Send reads to replicas in round-robin unless this thread is "stuck" to
-        the master."""
+        """Send reads to replicas in round-robin unless this thread is
+        "stuck" to the master."""
         return DEFAULT_DB_ALIAS if this_thread_is_pinned() else get_replica()
 
 
diff --git a/multidb/tests.py b/multidb/tests.py
index 125cff4..843d503 100644
--- a/multidb/tests.py
+++ b/multidb/tests.py
@@ -124,9 +124,13 @@ class MiddlewareTests(UnpinningTestCase):
     def setUp(self):
         super(MiddlewareTests, self).setUp()
 
+        # Django 4.0 requires response as an arg
+        # https://stackoverflow.com/questions/62944755/how-to-unittest-new-style-django-middleware
+        get_response = mock.MagicMock()
+
         # Every test uses these, so they're okay as attrs.
         self.request = HttpRequest()
-        self.middleware = PinningRouterMiddleware()
+        self.middleware = PinningRouterMiddleware(get_response)
 
     def test_pin_on_cookie(self):
         """Thread should pin when the cookie is set."""
diff --git a/requirements.txt b/requirements.txt
index 913c391..d507e8c 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -1,2 +1,2 @@
-django-nose==1.4.4
-flake8==3.3.0
+django-nose==1.4.7
+flake8==6.0.0
diff --git a/run.sh b/run.sh
index 395b4c0..1c42fa9 100755
--- a/run.sh
+++ b/run.sh
@@ -13,9 +13,9 @@ usage() {
 
 case "$1" in
     "test" )
-        django-admin.py test multidb ;;
+        django-admin test multidb ;;
     "shell" )
-        django-admin.py shell ;;
+        django-admin shell ;;
     "check" )
         flake8 multidb ;;
     * )
diff --git a/test_settings.py b/test_settings.py
index 57f3ab2..caa8dc0 100644
--- a/test_settings.py
+++ b/test_settings.py
@@ -1,7 +1,7 @@
 # A Django settings module to support the tests
 
 SECRET_KEY = 'dummy'
-TEST_RUNNER = 'django_nose.runner.NoseTestSuiteRunner'
+# TEST_RUNNER = 'django_nose.runner.NoseTestSuiteRunner'
 
 MIDDLEWARE_CLASSES = (
     'django.middleware.common.CommonMiddleware',
diff --git a/tox.ini b/tox.ini
index 8fef433..6ffdd31 100644
--- a/tox.ini
+++ b/tox.ini
@@ -1,30 +1,29 @@
 [tox]
 envlist =
     flake8
-    {py35,py36,py37,py38,py39}-2.2.X
-    {py36,py37,py38,py39}-3.0.X
-    {py36,py37,py38,py39}-3.1.X
-    {py36,py37,py38,py39}-3.2.X
+    {py38,py39,py310}-3.2.X
+    {py38,py39,py310}-4.0.X
+    {py38,py39,py310}-4.1.X
+    {py38,py39,py310}-4.2.X
 
 [testenv]
+allowlist_externals=./run.sh
 basepython =
-    py35: python3.5
-    py36: python3.6
-    py37: python3.7
     py38: python3.8
     py39: python3.9
+    py10: python3.10
 
 commands =
     ./run.sh test
     python --version
-    django-admin.py --version
+    django-admin --version
     pip freeze
 
 deps =
-    2.2.X: Django>=2.2,<2.3
-    3.0.X: Django>=3.0,<3.1
-    3.1.X: Django>=3.1,<3.2
     3.2.X: Django>=3.2,<4.0
+    4.0.X: Django>=4.0,<4.1
+    4.1.X: Django>=4.1,<4.2
+    4.2.X: Django>=4.2,<5.0
     -r{toxinidir}/requirements.txt
 
 [testenv:flake8]