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NEWS.md

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pmxTools 1.4

  • dgr_table() now provides geometric means by default

  • gm() now provides options to strip NA values (na.rm) and non-positive values (neg.rm) before computation.

pmxTools 1.3

  • Added NCA parameter estimation to calc_derived_1cpt(), calc_derived_2cpt() and calc_derived_3cpt(), if dose and other required information (e.g. tinf, dur, tau) is provided.

  • Added a warning about flip-flop kinetics and their potential effects on derived half-lives to calc_derived_1cpt(), calc_derived_2cpt(), and calc_derived_3cpt().

  • Added blq_trans() and blq_log_trans() for assistance with visualization of measurements below a limit of quantification.

  • Added a test for valid XML to read_nm().

  • Small fixes and enhancements to read_nmtable_single() and read_nm_multi_table() to ensure that stray text is properly handled while reading in NONMEM output files.

  • count_na() now throws a warning if NaN values are included in the NA count, and indicates how many of them there are.

  • Changed the significant digits functionality for 95% confidence intervals for get_theta(), get_omega() and get_sigma(), and all functions that apply these.

  • Replaced gridExtra with patchwork.

  • Numerous small fixes.

  • Removed some unnecessary dependencies.

  • Added many new unit tests, increasing test coverage considerably.

pmxTools 1.2.4

  • Fixed some minor documentation issues. Thanks to Julien Grassot for spotting these.

pmxTools 1.2.3

  • Fixed another error in sample_uncert() which was still crashing the function.

  • Added helper functions count_na(), dgr_table(), gcv(), fmt_signif().

  • Added distribution plotting function plot_dist().

pmxTools 1.2.2

  • Fixed an error in sample_uncert() which was crashing the function.

pmxTools 1.2.1

  • Added vignette describing PK curves.

  • Fixed a systematic error in calc_sd_1cmt_linear_oral_0_lag(), calc_ss_1cmt_linear_oral_0_lag(), calc_sd_2cmt_linear_oral_0_lag() which resulted in incorrect curves being plotted.

pmxTools 1.2

  • Rewrote plot_scm function to produce tree diagrams via DiagrammeR.

  • Fixed a rare bug in get_auc in which measurements from different individuals could be erroneously mixed.

  • Amended (or added) read_nm(), read_nm_all(), read_nmext(), read_nmcov(), read_nmtables() functions to allow reading of multiple NONMEM estimation steps.

  • Clarified documentation for calc_derived().

  • Now using xml2 to read NONMEM-generated XML files.

  • Fixed partial argument match warnings encountered during tests.

  • Add function for calculting geometric CV.