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Bridging the gap between sc2rf result and Pangolin X* lineages #34

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bioinforME opened this issue Jul 14, 2022 · 0 comments
Open

Bridging the gap between sc2rf result and Pangolin X* lineages #34

bioinforME opened this issue Jul 14, 2022 · 0 comments

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@bioinforME
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First, thanks to the authors for bringing the useful tool for us.

We have been using sc2rf to scan for recombinant sequences and determine breakpoint, but i found from the result to the Pangolin X* lineage calls there is a gap. I was wondering whether it is possible to bridge the gap by: 1. take in the lineage designation from Pangolin X* lineages, scan and store the profiles for each of the recombinant lineages; 2. for a new query sequence, if the breakpoint profile matches existing Pangolin X* lineages, in the result not just suggest the parent lineages and breakpoint, provide a possible X* lineage call as well. More or less in the way of how the Scorpio Constellation works.

I expect this would be a more accurate way of assigning recombinant lineages than the current UShER calls, where the breakpoint positions may not match.

Thanks for considering the suggestion.

@bioinforME bioinforME changed the title Bridging the gap between sc2rf result and Pangolin lineages Bridging the gap between sc2rf result and Pangolin X* lineages Jul 14, 2022
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