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First, thanks to the authors for bringing the useful tool for us.
We have been using sc2rf to scan for recombinant sequences and determine breakpoint, but i found from the result to the Pangolin X* lineage calls there is a gap. I was wondering whether it is possible to bridge the gap by: 1. take in the lineage designation from Pangolin X* lineages, scan and store the profiles for each of the recombinant lineages; 2. for a new query sequence, if the breakpoint profile matches existing Pangolin X* lineages, in the result not just suggest the parent lineages and breakpoint, provide a possible X* lineage call as well. More or less in the way of how the Scorpio Constellation works.
I expect this would be a more accurate way of assigning recombinant lineages than the current UShER calls, where the breakpoint positions may not match.
Thanks for considering the suggestion.
The text was updated successfully, but these errors were encountered:
bioinforME
changed the title
Bridging the gap between sc2rf result and Pangolin lineages
Bridging the gap between sc2rf result and Pangolin X* lineages
Jul 14, 2022
First, thanks to the authors for bringing the useful tool for us.
We have been using sc2rf to scan for recombinant sequences and determine breakpoint, but i found from the result to the Pangolin X* lineage calls there is a gap. I was wondering whether it is possible to bridge the gap by: 1. take in the lineage designation from Pangolin X* lineages, scan and store the profiles for each of the recombinant lineages; 2. for a new query sequence, if the breakpoint profile matches existing Pangolin X* lineages, in the result not just suggest the parent lineages and breakpoint, provide a possible X* lineage call as well. More or less in the way of how the Scorpio Constellation works.
I expect this would be a more accurate way of assigning recombinant lineages than the current UShER calls, where the breakpoint positions may not match.
Thanks for considering the suggestion.
The text was updated successfully, but these errors were encountered: