diff --git a/src/core/handlers/RequestHandler.ts b/src/core/handlers/RequestHandler.ts
index 8369ec233..917d6edc4 100644
--- a/src/core/handlers/RequestHandler.ts
+++ b/src/core/handlers/RequestHandler.ts
@@ -156,7 +156,7 @@ export abstract class RequestHandler<
     resolutionContext?: ResponseResolutionContext
   }): Promise<boolean> {
     const parsedResult = await this.parse({
-      request: args.request.clone(),
+      request: args.request,
       resolutionContext: args.resolutionContext,
     })
 
@@ -186,6 +186,8 @@ export abstract class RequestHandler<
       return null
     }
 
+    // Clone the request instance before it's passed to the handler phases
+    // and the response resolver so we can always read it for logging.
     const mainRequestRef = args.request.clone()
 
     // Immediately mark the handler as used.
@@ -194,11 +196,11 @@ export abstract class RequestHandler<
     this.isUsed = true
 
     const parsedResult = await this.parse({
-      request: mainRequestRef.clone(),
+      request: args.request,
       resolutionContext: args.resolutionContext,
     })
     const shouldInterceptRequest = this.predicate({
-      request: mainRequestRef.clone(),
+      request: args.request,
       parsedResult,
       resolutionContext: args.resolutionContext,
     })
diff --git a/src/node/SetupServerApi.ts b/src/node/SetupServerApi.ts
index ebf2d7650..ebacb5c57 100644
--- a/src/node/SetupServerApi.ts
+++ b/src/node/SetupServerApi.ts
@@ -1,3 +1,4 @@
+import { setMaxListeners, defaultMaxListeners } from 'node:events'
 import { invariant } from 'outvariant'
 import {
   BatchInterceptor,
@@ -50,6 +51,18 @@ export class SetupServerApi
    */
   private init(): void {
     this.interceptor.on('request', async ({ request, requestId }) => {
+      // Bump the maximum number of event listeners on the
+      // request's "AbortSignal". This prepares the request
+      // for each request handler cloning it at least once.
+      // Note that cloning a request automatically appends a
+      // new "abort" event listener to the parent request's
+      // "AbortController" so if the parent aborts, all the
+      // clones are automatically aborted.
+      setMaxListeners(
+        Math.max(defaultMaxListeners, this.currentHandlers.length),
+        request.signal,
+      )
+
       const response = await handleRequest(
         request,
         requestId,
diff --git a/test/node/msw-api/many-request-handlers.test.ts b/test/node/msw-api/many-request-handlers.test.ts
new file mode 100644
index 000000000..ecdd4d793
--- /dev/null
+++ b/test/node/msw-api/many-request-handlers.test.ts
@@ -0,0 +1,58 @@
+/**
+ * @jest-environment node
+ */
+import { graphql, http, HttpResponse } from 'msw'
+import { setupServer } from 'msw/node'
+
+// Create a large number of request handlers.
+const restHandlers = new Array(100).fill(null).map((_, index) => {
+  return http.post(
+    `https://example.com/resource/${index}`,
+    async ({ request }) => {
+      const text = await request.text()
+      return HttpResponse.text(text + index.toString())
+    },
+  )
+})
+
+const graphqlHanlers = new Array(100).fill(null).map((_, index) => {
+  return graphql.query(`Get${index}`, () => {
+    return HttpResponse.json({ data: { index } })
+  })
+})
+
+const server = setupServer(...restHandlers, ...graphqlHanlers)
+
+beforeAll(() => {
+  server.listen()
+  jest.spyOn(process.stderr, 'write')
+})
+
+afterAll(() => {
+  server.close()
+  jest.restoreAllMocks()
+})
+
+it('does not print a memory leak warning when having many request handlers', async () => {
+  const httpResponse = await fetch('https://example.com/resource/42', {
+    method: 'POST',
+    body: 'request-body-',
+  }).then((response) => response.text())
+
+  const graphqlResponse = await fetch('https://example.com', {
+    method: 'POST',
+    headers: {
+      'Content-Type': 'application/json',
+    },
+    body: JSON.stringify({
+      query: `query Get42 { index }`,
+    }),
+  }).then((response) => response.json())
+
+  // Must not print any memory leak warnings.
+  expect(process.stderr.write).not.toHaveBeenCalled()
+
+  // Must return the mocked response.
+  expect(httpResponse).toBe('request-body-42')
+  expect(graphqlResponse).toEqual({ data: { index: 42 } })
+})