diff --git a/CHANGELOG.md b/CHANGELOG.md
index 7c7ccf00eb..5fca54ccbc 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -71,6 +71,7 @@ Rapaselet is a delta formed by the Rapaätno river between the Bielloriehppe mas
 - [#1225](https://github.com/nf-core/sarek/pull/1225) - Better test coverage for all tests
 - [#1227](https://github.com/nf-core/sarek/pull/1227) - Lint warning fix
 - [#1229](https://github.com/nf-core/sarek/pull/1229) - Fix md5sum for gatk4_spark tests
+- [#1230](https://github.com/nf-core/sarek/pull/1230) - Fix md5sum for sentieon aligner tests
 
 ### Dependencies
 
diff --git a/tests/test_aligner_sentieon_bwamem.yml b/tests/test_aligner_sentieon_bwamem.yml
index 0fe70c25b8..f919a725ba 100644
--- a/tests/test_aligner_sentieon_bwamem.yml
+++ b/tests/test_aligner_sentieon_bwamem.yml
@@ -52,23 +52,23 @@
     - path: results/reports/mosdepth/test/test.md.mosdepth.global.dist.txt
       md5sum: b61e1acee11a6ddf7ce3232a5948a6a0
     - path: results/reports/mosdepth/test/test.md.mosdepth.region.dist.txt
-      md5sum: 33c7002cc7e66cbc0509bb9532ec3f1e
+      md5sum: 1a382f98d488d2ae3df83a0d87caafc1
     - path: results/reports/mosdepth/test/test.md.mosdepth.summary.txt
-      md5sum: 8fcc45ab48b03c38b5200e02da63dbe1
+      md5sum: 9afbcd5e44b62b3947e47af850a66188
     - path: results/reports/mosdepth/test/test.md.regions.bed.gz
-      md5sum: a27a092f08b48648e11eb8730cba02b9
+      md5sum: 3bd6a6f7127394802d9a7c7d559072ee
     - path: results/reports/mosdepth/test/test.md.regions.bed.gz.csi
-      md5sum: 544e02fcca548749a0af758d0a2df352
+      md5sum: 72ae14370dfdaab906e50d0552c90119
     - path: results/reports/mosdepth/test/test.recal.mosdepth.global.dist.txt
       md5sum: b61e1acee11a6ddf7ce3232a5948a6a0
     - path: results/reports/mosdepth/test/test.recal.mosdepth.region.dist.txt
-      md5sum: 33c7002cc7e66cbc0509bb9532ec3f1e
+      md5sum: 1a382f98d488d2ae3df83a0d87caafc1
     - path: results/reports/mosdepth/test/test.recal.mosdepth.summary.txt
-      md5sum: 8fcc45ab48b03c38b5200e02da63dbe1
+      md5sum: 9afbcd5e44b62b3947e47af850a66188
     - path: results/reports/mosdepth/test/test.recal.regions.bed.gz
-      md5sum: a27a092f08b48648e11eb8730cba02b9
+      md5sum: 3bd6a6f7127394802d9a7c7d559072ee
     - path: results/reports/mosdepth/test/test.recal.regions.bed.gz.csi
-      md5sum: 544e02fcca548749a0af758d0a2df352
+      md5sum: 72ae14370dfdaab906e50d0552c90119
     - path: results/reports/samtools/test/test.md.cram.stats
     # conda changes md5sums for test
     - path: results/reports/samtools/test/test.recal.cram.stats
@@ -138,23 +138,23 @@
     - path: results/reports/mosdepth/test/test.md.mosdepth.global.dist.txt
       md5sum: b61e1acee11a6ddf7ce3232a5948a6a0
     - path: results/reports/mosdepth/test/test.md.mosdepth.region.dist.txt
-      md5sum: 33c7002cc7e66cbc0509bb9532ec3f1e
+      md5sum: 1a382f98d488d2ae3df83a0d87caafc1
     - path: results/reports/mosdepth/test/test.md.mosdepth.summary.txt
-      md5sum: 8fcc45ab48b03c38b5200e02da63dbe1
+      md5sum: 9afbcd5e44b62b3947e47af850a66188
     - path: results/reports/mosdepth/test/test.md.regions.bed.gz
-      md5sum: a27a092f08b48648e11eb8730cba02b9
+      md5sum: 3bd6a6f7127394802d9a7c7d559072ee
     - path: results/reports/mosdepth/test/test.md.regions.bed.gz.csi
-      md5sum: 544e02fcca548749a0af758d0a2df352
+      md5sum: 72ae14370dfdaab906e50d0552c90119
     - path: results/reports/mosdepth/test/test.recal.mosdepth.global.dist.txt
       md5sum: b61e1acee11a6ddf7ce3232a5948a6a0
     - path: results/reports/mosdepth/test/test.recal.mosdepth.region.dist.txt
-      md5sum: 33c7002cc7e66cbc0509bb9532ec3f1e
+      md5sum: 1a382f98d488d2ae3df83a0d87caafc1
     - path: results/reports/mosdepth/test/test.recal.mosdepth.summary.txt
-      md5sum: 8fcc45ab48b03c38b5200e02da63dbe1
+      md5sum: 9afbcd5e44b62b3947e47af850a66188
     - path: results/reports/mosdepth/test/test.recal.regions.bed.gz
-      md5sum: a27a092f08b48648e11eb8730cba02b9
+      md5sum: 3bd6a6f7127394802d9a7c7d559072ee
     - path: results/reports/mosdepth/test/test.recal.regions.bed.gz.csi
-      md5sum: 544e02fcca548749a0af758d0a2df352
+      md5sum: 72ae14370dfdaab906e50d0552c90119
     - path: results/reports/samtools/test/test.md.cram.stats
     # conda changes md5sums for test
     - path: results/reports/samtools/test/test.recal.cram.stats
@@ -192,23 +192,23 @@
     - path: results/reports/mosdepth/test/test.md.mosdepth.global.dist.txt
       md5sum: b61e1acee11a6ddf7ce3232a5948a6a0
     - path: results/reports/mosdepth/test/test.md.mosdepth.region.dist.txt
-      md5sum: 33c7002cc7e66cbc0509bb9532ec3f1e
+      md5sum: 1a382f98d488d2ae3df83a0d87caafc1
     - path: results/reports/mosdepth/test/test.md.mosdepth.summary.txt
-      md5sum: 8fcc45ab48b03c38b5200e02da63dbe1
+      md5sum: 9afbcd5e44b62b3947e47af850a66188
     - path: results/reports/mosdepth/test/test.md.regions.bed.gz
-      md5sum: a27a092f08b48648e11eb8730cba02b9
+      md5sum: 3bd6a6f7127394802d9a7c7d559072ee
     - path: results/reports/mosdepth/test/test.md.regions.bed.gz.csi
-      md5sum: 544e02fcca548749a0af758d0a2df352
+      md5sum: 72ae14370dfdaab906e50d0552c90119
     - path: results/reports/mosdepth/test/test.recal.mosdepth.global.dist.txt
       md5sum: b61e1acee11a6ddf7ce3232a5948a6a0
     - path: results/reports/mosdepth/test/test.recal.mosdepth.region.dist.txt
-      md5sum: 33c7002cc7e66cbc0509bb9532ec3f1e
+      md5sum: 1a382f98d488d2ae3df83a0d87caafc1
     - path: results/reports/mosdepth/test/test.recal.mosdepth.summary.txt
-      md5sum: 8fcc45ab48b03c38b5200e02da63dbe1
+      md5sum: 9afbcd5e44b62b3947e47af850a66188
     - path: results/reports/mosdepth/test/test.recal.regions.bed.gz
-      md5sum: a27a092f08b48648e11eb8730cba02b9
+      md5sum: 3bd6a6f7127394802d9a7c7d559072ee
     - path: results/reports/mosdepth/test/test.recal.regions.bed.gz.csi
-      md5sum: 544e02fcca548749a0af758d0a2df352
+      md5sum: 72ae14370dfdaab906e50d0552c90119
     - path: results/reports/samtools/test/test.md.cram.stats
     # conda changes md5sums for test
     - path: results/reports/samtools/test/test.recal.cram.stats