diff --git a/inst/cov/bolus_1cpt_Vk.txt b/inst/cov/bolus_1cpt_Vk.txt new file mode 100644 index 0000000..2309bca --- /dev/null +++ b/inst/cov/bolus_1cpt_Vk.txt @@ -0,0 +1,14 @@ +DESCRIPTION: +The administration is via a bolus. +The PK model has one compartment (volume V) and a linear elimination (elimination rate k). + + +[LONGITUDINAL] +input = {V, k} + +PK: +; PK model definition +Cc = pkmodel(V, k) + +OUTPUT: +output = Cc diff --git a/inst/cov/oral1_1cpt_TlagkaVCl.txt b/inst/cov/oral1_1cpt_TlagkaVCl.txt new file mode 100644 index 0000000..439b3eb --- /dev/null +++ b/inst/cov/oral1_1cpt_TlagkaVCl.txt @@ -0,0 +1,14 @@ +DESCRIPTION: +The administration is extravascular with a first order absorption (rate constant ka) and a lag time (Tlag). +The PK model has one compartment (volume V) and a linear elimination (clearance Cl). + + +[LONGITUDINAL] +input = {Tlag, ka, V, Cl} + +PK: +; PK model definition +Cc = pkmodel(Tlag, ka, V, Cl) + +OUTPUT: +output = Cc diff --git a/inst/cov/phenobarbital_project.mlxtran b/inst/cov/phenobarbital_project.mlxtran index a12f485..6fa99ac 100644 --- a/inst/cov/phenobarbital_project.mlxtran +++ b/inst/cov/phenobarbital_project.mlxtran @@ -43,7 +43,7 @@ k = {distribution=logNormal, typical=k_pop, sd=omega_k} [LONGITUDINAL] input = {b} -file = 'lib:bolus_1cpt_Vk.txt' +file = 'bolus_1cpt_Vk.txt' DEFINITION: CONC = {distribution=normal, prediction=Cc, errorModel=proportional(b)} diff --git a/inst/cov/warfarin_covariate1_project.mlxtran b/inst/cov/warfarin_covariate1_project.mlxtran index ff2410d..db87299 100644 --- a/inst/cov/warfarin_covariate1_project.mlxtran +++ b/inst/cov/warfarin_covariate1_project.mlxtran @@ -36,7 +36,7 @@ Cl = {distribution=logNormal, typical=Cl_pop, sd=omega_Cl} [LONGITUDINAL] input = {a, b} -file = 'lib:oral1_1cpt_TlagkaVCl.txt' +file = 'oral1_1cpt_TlagkaVCl.txt' DEFINITION: concentration = {distribution=normal, prediction=Cc, errorModel=combined1(a, b)} diff --git a/inst/cov/warfarin_covariate2_project.mlxtran b/inst/cov/warfarin_covariate2_project.mlxtran index 44d86e8..7741a77 100644 --- a/inst/cov/warfarin_covariate2_project.mlxtran +++ b/inst/cov/warfarin_covariate2_project.mlxtran @@ -39,7 +39,7 @@ Cl = {distribution=logNormal, typical=Cl_pop, covariate=lw70, coefficient=beta_C [LONGITUDINAL] input = {a, b} -file = 'lib:oral1_1cpt_TlagkaVCl.txt' +file = 'oral1_1cpt_TlagkaVCl.txt' DEFINITION: concentration = {distribution=normal, prediction=Cc, errorModel=combined1(a, b)} diff --git a/inst/cov/warfarin_covariate3_project.mlxtran b/inst/cov/warfarin_covariate3_project.mlxtran index 4af5eed..140a4dc 100644 --- a/inst/cov/warfarin_covariate3_project.mlxtran +++ b/inst/cov/warfarin_covariate3_project.mlxtran @@ -51,7 +51,7 @@ Cl = {distribution=logNormal, typical=Cl_pop, covariate=tSex, coefficient={beta_ [LONGITUDINAL] input = {a, b} -file = 'lib:oral1_1cpt_TlagkaVCl.txt' +file = 'oral1_1cpt_TlagkaVCl.txt' DEFINITION: concentration = {distribution=normal, prediction=Cc, errorModel=combined1(a, b)}