From 053b10e154f99c9a7843b7d29ee1a911e7ee073f Mon Sep 17 00:00:00 2001
From: "Matthew L. Fidler" <matthew.fidler@gmail.com>
Date: Wed, 15 May 2024 19:33:08 -0500
Subject: [PATCH] Use non-model library for testing cases

---
 inst/cov/bolus_1cpt_Vk.txt                   | 14 ++++++++++++++
 inst/cov/oral1_1cpt_TlagkaVCl.txt            | 14 ++++++++++++++
 inst/cov/phenobarbital_project.mlxtran       |  2 +-
 inst/cov/warfarin_covariate1_project.mlxtran |  2 +-
 inst/cov/warfarin_covariate2_project.mlxtran |  2 +-
 inst/cov/warfarin_covariate3_project.mlxtran |  2 +-
 6 files changed, 32 insertions(+), 4 deletions(-)
 create mode 100644 inst/cov/bolus_1cpt_Vk.txt
 create mode 100644 inst/cov/oral1_1cpt_TlagkaVCl.txt

diff --git a/inst/cov/bolus_1cpt_Vk.txt b/inst/cov/bolus_1cpt_Vk.txt
new file mode 100644
index 0000000..2309bca
--- /dev/null
+++ b/inst/cov/bolus_1cpt_Vk.txt
@@ -0,0 +1,14 @@
+DESCRIPTION:
+The administration is via a bolus.
+The PK model has one compartment (volume V) and a linear elimination (elimination rate k).
+
+
+[LONGITUDINAL]
+input = {V, k}
+
+PK:
+; PK model definition
+Cc = pkmodel(V, k)
+
+OUTPUT:
+output = Cc
diff --git a/inst/cov/oral1_1cpt_TlagkaVCl.txt b/inst/cov/oral1_1cpt_TlagkaVCl.txt
new file mode 100644
index 0000000..439b3eb
--- /dev/null
+++ b/inst/cov/oral1_1cpt_TlagkaVCl.txt
@@ -0,0 +1,14 @@
+DESCRIPTION:
+The administration is extravascular with a first order absorption (rate constant ka) and a lag time (Tlag).
+The PK model has one compartment (volume V) and a linear elimination (clearance Cl).
+
+
+[LONGITUDINAL]
+input = {Tlag, ka, V, Cl}
+
+PK:
+; PK model definition
+Cc = pkmodel(Tlag, ka, V, Cl)
+
+OUTPUT:
+output = Cc
diff --git a/inst/cov/phenobarbital_project.mlxtran b/inst/cov/phenobarbital_project.mlxtran
index a12f485..6fa99ac 100644
--- a/inst/cov/phenobarbital_project.mlxtran
+++ b/inst/cov/phenobarbital_project.mlxtran
@@ -43,7 +43,7 @@ k = {distribution=logNormal, typical=k_pop, sd=omega_k}
 [LONGITUDINAL]
 input = {b}
 
-file = 'lib:bolus_1cpt_Vk.txt'
+file = 'bolus_1cpt_Vk.txt'
 
 DEFINITION:
 CONC = {distribution=normal, prediction=Cc, errorModel=proportional(b)}
diff --git a/inst/cov/warfarin_covariate1_project.mlxtran b/inst/cov/warfarin_covariate1_project.mlxtran
index ff2410d..db87299 100644
--- a/inst/cov/warfarin_covariate1_project.mlxtran
+++ b/inst/cov/warfarin_covariate1_project.mlxtran
@@ -36,7 +36,7 @@ Cl = {distribution=logNormal, typical=Cl_pop, sd=omega_Cl}
 [LONGITUDINAL]
 input = {a, b}
 
-file = 'lib:oral1_1cpt_TlagkaVCl.txt'
+file = 'oral1_1cpt_TlagkaVCl.txt'
 
 DEFINITION:
 concentration = {distribution=normal, prediction=Cc, errorModel=combined1(a, b)}
diff --git a/inst/cov/warfarin_covariate2_project.mlxtran b/inst/cov/warfarin_covariate2_project.mlxtran
index 44d86e8..7741a77 100644
--- a/inst/cov/warfarin_covariate2_project.mlxtran
+++ b/inst/cov/warfarin_covariate2_project.mlxtran
@@ -39,7 +39,7 @@ Cl = {distribution=logNormal, typical=Cl_pop, covariate=lw70, coefficient=beta_C
 [LONGITUDINAL]
 input = {a, b}
 
-file = 'lib:oral1_1cpt_TlagkaVCl.txt'
+file = 'oral1_1cpt_TlagkaVCl.txt'
 
 DEFINITION:
 concentration = {distribution=normal, prediction=Cc, errorModel=combined1(a, b)}
diff --git a/inst/cov/warfarin_covariate3_project.mlxtran b/inst/cov/warfarin_covariate3_project.mlxtran
index 4af5eed..140a4dc 100644
--- a/inst/cov/warfarin_covariate3_project.mlxtran
+++ b/inst/cov/warfarin_covariate3_project.mlxtran
@@ -51,7 +51,7 @@ Cl = {distribution=logNormal, typical=Cl_pop, covariate=tSex, coefficient={beta_
 [LONGITUDINAL]
 input = {a, b}
 
-file = 'lib:oral1_1cpt_TlagkaVCl.txt'
+file = 'oral1_1cpt_TlagkaVCl.txt'
 
 DEFINITION:
 concentration = {distribution=normal, prediction=Cc, errorModel=combined1(a, b)}