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CRAN Comments for nlmixr2est 3.0.1

New features

  • Now when optimizing only a single parameter with focei-family, will change to use stats::optimize() for the outer problem (#481)

  • When estimating with all fixed population parameters, do a posthoc estimation.

  • Internally removed assignInMyNamespace() replacing with nlmixr2global, which fixes some edge case bugs where the nlmixr2 environment was not reset properly.

  • Treated edge case where all initial parameters are zero and change scaling from scaled to unscaled (#486)

  • Added mu4 referencing that will change string expressions to rxode2 numeric values. This allows derived strings to also be treated as mu expressions (#484)

Bug Fixes

  • Fix focei covariance step when many omega values are fixed #482