diff --git a/cran-comments.md b/cran-comments.md
index 1e664b64..8fce1a4d 100644
--- a/cran-comments.md
+++ b/cran-comments.md
@@ -1,4 +1,24 @@
-# CRAN Comments
+# CRAN Comments for nlmixr2est 3.0.1
 
-- Bug fixes and version to support new rxode2 without binary linkage
-  to it (only api not abi)
+## New features
+
+- Now when optimizing only a single parameter with `focei`-family,
+  will change to use `stats::optimize()` for the outer problem (#481)
+
+- When estimating with all fixed population parameters, do a posthoc
+  estimation.
+
+- Internally removed `assignInMyNamespace()` replacing with
+  `nlmixr2global`, which fixes some edge case bugs where the nlmixr2
+  environment was not reset properly.
+
+- Treated edge case where all initial parameters are zero and change
+  scaling from scaled to unscaled (#486)
+
+- Added `mu`4 referencing that will change string expressions to
+  `rxode2` numeric values.  This allows derived strings to also be
+  treated as `mu` expressions (#484)
+
+## Bug Fixes
+
+- Fix `focei` covariance step when many `omega` values are fixed #482