diff --git a/articles/Integrating-User-Defined-Functions-into-rxode2.html b/articles/Integrating-User-Defined-Functions-into-rxode2.html index 0755cd766..d34973c19 100644 --- a/articles/Integrating-User-Defined-Functions-into-rxode2.html +++ b/articles/Integrating-User-Defined-Functions-into-rxode2.html @@ -247,9 +247,9 @@

R based user functions
 print(mb)
 #> Unit: milliseconds
-#>      expr      min       lq     mean   median       uq      max neval
-#>  withoutC 7.756175 7.847705 8.458881 7.914530 8.094942 13.65840   100
-#>     withC 2.089166 2.133058 2.486548 2.254109 2.774495  6.45083   100
+#> expr min lq mean median uq max neval +#> withoutC 7.706384 7.813619 8.458545 7.891054 7.995268 13.624052 100 +#> withC 2.052068 2.115636 2.441953 2.201777 2.726220 6.392353 100

The C version is almost twice as fast as the R version. You may have noticed the conversion also created C versions of the first derivative. This is done automatically and gives not just C versions of function, diff --git a/articles/Integrating-User-Defined-Functions-into-rxode2_files/figure-html/benmchmark1-1.png b/articles/Integrating-User-Defined-Functions-into-rxode2_files/figure-html/benmchmark1-1.png index f42a59ab5..1e8137aff 100644 Binary files a/articles/Integrating-User-Defined-Functions-into-rxode2_files/figure-html/benmchmark1-1.png and b/articles/Integrating-User-Defined-Functions-into-rxode2_files/figure-html/benmchmark1-1.png differ diff --git a/articles/Integrating-User-Defined-Functions-into-rxode2_files/figure-html/convertC-1.png b/articles/Integrating-User-Defined-Functions-into-rxode2_files/figure-html/convertC-1.png index 4af9982e0..3f3b03c6b 100644 Binary files a/articles/Integrating-User-Defined-Functions-into-rxode2_files/figure-html/convertC-1.png and b/articles/Integrating-User-Defined-Functions-into-rxode2_files/figure-html/convertC-1.png differ diff --git a/articles/rxode2-cmt.html b/articles/rxode2-cmt.html index fd794f2db..8e360c9b9 100644 --- a/articles/rxode2-cmt.html +++ b/articles/rxode2-cmt.html @@ -157,7 +157,7 @@

Advanced Features, Model Types, Techni

Changing rxode2 compartment numbers

-

2023-11-28

+

2023-11-30

Source: vignettes/rxode2-cmt.Rmd
rxode2-cmt.Rmd
@@ -380,8 +380,8 @@

How rxode2 assigns compartment n 
#> using C compiler: ‘gcc (Ubuntu 11.4.0-1ubuntu1~22.04) 11.4.0’
 summary(pbpk)
-
#> rxode2 2.0.14.9000 model named rx_7ecfe139441efa7d6685fa89a52fedb8 model (ready). 
-#> DLL: /tmp/RtmprYXrJy/rxode2/rx_7ecfe139441efa7d6685fa89a52fedb8__.rxd/rx_7ecfe139441efa7d6685fa89a52fedb8_.so
+
#> rxode2 2.0.14.9000 model named rx_8ee4408c660f4c3f31e6d0548ea2c3f1 model (ready). 
+#> DLL: /tmp/RtmphFlXM3/rxode2/rx_8ee4408c660f4c3f31e6d0548ea2c3f1__.rxd/rx_8ee4408c660f4c3f31e6d0548ea2c3f1_.so
 #> NULL
 #> 
 #> Calculated Variables:
@@ -731,7 +731,7 @@ 
Appending compartments to the model
 
 ode.1c.ka$simulationModel

 
#> using C compiler: ‘gcc (Ubuntu 11.4.0-1ubuntu1~22.04) 11.4.0’

-
#> rxode2 2.0.14.9000 model named rx_4851cdb3054ffc2f3e5f53f3896aac57 model (ready). 
+
#> rxode2 2.0.14.9000 model named rx_b8d999c3e65c274ef9e90ceabef41631 model (ready). 
 #> x$state: depot, center
 #> x$stateExtra: eff
 #> x$params: V, KA, CL
diff --git a/articles/rxode2-covariates.html b/articles/rxode2-covariates.html
index 5ecaa6180..e49ea6da6 100644
--- a/articles/rxode2-covariates.html
+++ b/articles/rxode2-covariates.html
@@ -157,7 +157,7 @@ 
Advanced Features, Model Types, Techni
   

       
rxode2 Covariates

             
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       Source: vignettes/rxode2-covariates.Rmd
       
rxode2-covariates.Rmd

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--- a/articles/rxode2-data-frame.html
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@@ -157,7 +157,7 @@ 
Advanced Features, Model Types, Techni
   

       
rxode2 Data Frames

             
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       Source: vignettes/rxode2-data-frame.Rmd
       
rxode2-data-frame.Rmd

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index 6186fd732..213285710 100644
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@@ -157,7 +157,7 @@ 
Advanced Features, Model Types, Techni
   

       
rxode2 Event Types

             
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       Source: vignettes/rxode2-datasets.Rmd
       
rxode2-datasets.Rmd

diff --git a/articles/rxode2-event-table.html b/articles/rxode2-event-table.html
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--- a/articles/rxode2-event-table.html
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@@ -157,7 +157,7 @@ 
Advanced Features, Model Types, Techni
   

       
Easy rxode2 Event Tables

             
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       Source: vignettes/rxode2-event-table.Rmd
       
rxode2-event-table.Rmd

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@@ -157,7 +157,7 @@ 
Advanced Features, Model Types, Techni
   

       
rxode2 Event Types

             
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2023-11-28

+            
2023-11-30

       
       Source: vignettes/rxode2-event-types.Rmd
       
rxode2-event-types.Rmd

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@@ -157,7 +157,7 @@ 
Advanced Features, Model Types, Techni
   

       
Classic rxode2 Events

             
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       Source: vignettes/rxode2-events-classic.Rmd
       
rxode2-events-classic.Rmd

diff --git a/articles/rxode2-intro.html b/articles/rxode2-intro.html
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--- a/articles/rxode2-intro.html
+++ b/articles/rxode2-intro.html
@@ -157,7 +157,7 @@ 
Advanced Features, Model Types, Techni
   

       
Introduction to rxode2

             
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       Source: vignettes/rxode2-intro.Rmd
       
rxode2-intro.Rmd

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@@ -157,12 +157,12 @@ 
Advanced Features, Model Types, Techni
 
 
 
-
-

+
+

   

       
rxode2 additional model types

             
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       Source: vignettes/rxode2-model-types.Rmd
       
rxode2-model-types.Rmd

@@ -237,18 +237,18 @@ 
Solved compartment modelsVC or V),
 Peripheral/Tissue (VP, VT). While more
 translations are available, some example translations are below:

-

-
Another popular parameterization is in terms of micro-constants.
+

+
Another popular parameterization is in terms of micro-constants.
 rxode2 assumes compartment 1 is the central compartment.
 The elimination constant would be specified by K,
 Ke or Kel. Some example translations are
 below:

-

-
The last parameterization possible is using alpha and
+

+
The last parameterization possible is using alpha and
 V and/or A/B/C. Some
 example translations are below:

-

-
Once the linCmt() sleuthing is complete, the
+

+
Once the linCmt() sleuthing is complete, the
 1, 2 or 3 compartment model
 solution is used as the value of linCmt().

 
The compartments where you can dose in a linear solved system are
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+++ b/articles/rxode2-model-types_files/crosstalk-1.2.1/css/crosstalk.min.css
@@ -0,0 +1 @@
+.container-fluid.crosstalk-bscols{margin-left:-30px;margin-right:-30px;white-space:normal}body>.container-fluid.crosstalk-bscols{margin-left:auto;margin-right:auto}.crosstalk-input-checkboxgroup .crosstalk-options-group .crosstalk-options-column{display:inline-block;padding-right:12px;vertical-align:top}@media only screen and (max-width: 480px){.crosstalk-input-checkboxgroup .crosstalk-options-group .crosstalk-options-column{display:block;padding-right:inherit}}.crosstalk-input{margin-bottom:15px}.crosstalk-input .control-label{margin-bottom:0;vertical-align:middle}.crosstalk-input input[type="checkbox"]{margin:4px 0 0;margin-top:1px;line-height:normal}.crosstalk-input .checkbox{position:relative;display:block;margin-top:10px;margin-bottom:10px}.crosstalk-input .checkbox>label{padding-left:20px;margin-bottom:0;font-weight:400;cursor:pointer}.crosstalk-input .checkbox input[type="checkbox"],.crosstalk-input .checkbox-inline input[type="checkbox"]{position:absolute;margin-top:2px;margin-left:-20px}.crosstalk-input .checkbox+.checkbox{margin-top:-5px}.crosstalk-input .checkbox-inline{position:relative;display:inline-block;padding-left:20px;margin-bottom:0;font-weight:400;vertical-align:middle;cursor:pointer}.crosstalk-input .checkbox-inline+.checkbox-inline{margin-top:0;margin-left:10px}
diff --git a/articles/rxode2-model-types_files/crosstalk-1.2.1/js/crosstalk.js b/articles/rxode2-model-types_files/crosstalk-1.2.1/js/crosstalk.js
new file mode 100644
index 000000000..fd9eb53d2
--- /dev/null
+++ b/articles/rxode2-model-types_files/crosstalk-1.2.1/js/crosstalk.js
@@ -0,0 +1,1474 @@
+(function(){function e(t,n,r){function s(o,u){if(!n[o]){if(!t[o]){var a=typeof require=="function"&&require;if(!u&&a)return a(o,!0);if(i)return i(o,!0);var f=new Error("Cannot find module '"+o+"'");throw f.code="MODULE_NOT_FOUND",f}var l=n[o]={exports:{}};t[o][0].call(l.exports,function(e){var n=t[o][1][e];return s(n?n:e)},l,l.exports,e,t,n,r)}return n[o].exports}var i=typeof require=="function"&&require;for(var o=0;o b) {
+    return 1;
+  }
+}
+
+/**
+ * @private
+ */
+
+var FilterSet = function () {
+  function FilterSet() {
+    _classCallCheck(this, FilterSet);
+
+    this.reset();
+  }
+
+  _createClass(FilterSet, [{
+    key: "reset",
+    value: function reset() {
+      // Key: handle ID, Value: array of selected keys, or null
+      this._handles = {};
+      // Key: key string, Value: count of handles that include it
+      this._keys = {};
+      this._value = null;
+      this._activeHandles = 0;
+    }
+  }, {
+    key: "update",
+    value: function update(handleId, keys) {
+      if (keys !== null) {
+        keys = keys.slice(0); // clone before sorting
+        keys.sort(naturalComparator);
+      }
+
+      var _diffSortedLists = (0, _util.diffSortedLists)(this._handles[handleId], keys),
+          added = _diffSortedLists.added,
+          removed = _diffSortedLists.removed;
+
+      this._handles[handleId] = keys;
+
+      for (var i = 0; i < added.length; i++) {
+        this._keys[added[i]] = (this._keys[added[i]] || 0) + 1;
+      }
+      for (var _i = 0; _i < removed.length; _i++) {
+        this._keys[removed[_i]]--;
+      }
+
+      this._updateValue(keys);
+    }
+
+    /**
+     * @param {string[]} keys Sorted array of strings that indicate
+     * a superset of possible keys.
+     * @private
+     */
+
+  }, {
+    key: "_updateValue",
+    value: function _updateValue() {
+      var keys = arguments.length > 0 && arguments[0] !== undefined ? arguments[0] : this._allKeys;
+
+      var handleCount = Object.keys(this._handles).length;
+      if (handleCount === 0) {
+        this._value = null;
+      } else {
+        this._value = [];
+        for (var i = 0; i < keys.length; i++) {
+          var count = this._keys[keys[i]];
+          if (count === handleCount) {
+            this._value.push(keys[i]);
+          }
+        }
+      }
+    }
+  }, {
+    key: "clear",
+    value: function clear(handleId) {
+      if (typeof this._handles[handleId] === "undefined") {
+        return;
+      }
+
+      var keys = this._handles[handleId];
+      if (!keys) {
+        keys = [];
+      }
+
+      for (var i = 0; i < keys.length; i++) {
+        this._keys[keys[i]]--;
+      }
+      delete this._handles[handleId];
+
+      this._updateValue();
+    }
+  }, {
+    key: "value",
+    get: function get() {
+      return this._value;
+    }
+  }, {
+    key: "_allKeys",
+    get: function get() {
+      var allKeys = Object.keys(this._keys);
+      allKeys.sort(naturalComparator);
+      return allKeys;
+    }
+  }]);
+
+  return FilterSet;
+}();
+
+exports.default = FilterSet;
+
+},{"./util":11}],4:[function(require,module,exports){
+(function (global){
+"use strict";
+
+Object.defineProperty(exports, "__esModule", {
+  value: true
+});
+
+var _createClass = function () { function defineProperties(target, props) { for (var i = 0; i < props.length; i++) { var descriptor = props[i]; descriptor.enumerable = descriptor.enumerable || false; descriptor.configurable = true; if ("value" in descriptor) descriptor.writable = true; Object.defineProperty(target, descriptor.key, descriptor); } } return function (Constructor, protoProps, staticProps) { if (protoProps) defineProperties(Constructor.prototype, protoProps); if (staticProps) defineProperties(Constructor, staticProps); return Constructor; }; }();
+
+var _typeof = typeof Symbol === "function" && typeof Symbol.iterator === "symbol" ? function (obj) { return typeof obj; } : function (obj) { return obj && typeof Symbol === "function" && obj.constructor === Symbol && obj !== Symbol.prototype ? "symbol" : typeof obj; };
+
+exports.default = group;
+
+var _var2 = require("./var");
+
+var _var3 = _interopRequireDefault(_var2);
+
+function _interopRequireDefault(obj) { return obj && obj.__esModule ? obj : { default: obj }; }
+
+function _classCallCheck(instance, Constructor) { if (!(instance instanceof Constructor)) { throw new TypeError("Cannot call a class as a function"); } }
+
+// Use a global so that multiple copies of crosstalk.js can be loaded and still
+// have groups behave as singletons across all copies.
+global.__crosstalk_groups = global.__crosstalk_groups || {};
+var groups = global.__crosstalk_groups;
+
+function group(groupName) {
+  if (groupName && typeof groupName === "string") {
+    if (!groups.hasOwnProperty(groupName)) {
+      groups[groupName] = new Group(groupName);
+    }
+    return groups[groupName];
+  } else if ((typeof groupName === "undefined" ? "undefined" : _typeof(groupName)) === "object" && groupName._vars && groupName.var) {
+    // Appears to already be a group object
+    return groupName;
+  } else if (Array.isArray(groupName) && groupName.length == 1 && typeof groupName[0] === "string") {
+    return group(groupName[0]);
+  } else {
+    throw new Error("Invalid groupName argument");
+  }
+}
+
+var Group = function () {
+  function Group(name) {
+    _classCallCheck(this, Group);
+
+    this.name = name;
+    this._vars = {};
+  }
+
+  _createClass(Group, [{
+    key: "var",
+    value: function _var(name) {
+      if (!name || typeof name !== "string") {
+        throw new Error("Invalid var name");
+      }
+
+      if (!this._vars.hasOwnProperty(name)) this._vars[name] = new _var3.default(this, name);
+      return this._vars[name];
+    }
+  }, {
+    key: "has",
+    value: function has(name) {
+      if (!name || typeof name !== "string") {
+        throw new Error("Invalid var name");
+      }
+
+      return this._vars.hasOwnProperty(name);
+    }
+  }]);
+
+  return Group;
+}();
+
+}).call(this,typeof global !== "undefined" ? global : typeof self !== "undefined" ? self : typeof window !== "undefined" ? window : {})
+
+},{"./var":12}],5:[function(require,module,exports){
+(function (global){
+"use strict";
+
+Object.defineProperty(exports, "__esModule", {
+  value: true
+});
+
+var _group = require("./group");
+
+var _group2 = _interopRequireDefault(_group);
+
+var _selection = require("./selection");
+
+var _filter = require("./filter");
+
+var _input = require("./input");
+
+require("./input_selectize");
+
+require("./input_checkboxgroup");
+
+require("./input_slider");
+
+function _interopRequireDefault(obj) { return obj && obj.__esModule ? obj : { default: obj }; }
+
+var defaultGroup = (0, _group2.default)("default");
+
+function var_(name) {
+  return defaultGroup.var(name);
+}
+
+function has(name) {
+  return defaultGroup.has(name);
+}
+
+if (global.Shiny) {
+  global.Shiny.addCustomMessageHandler("update-client-value", function (message) {
+    if (typeof message.group === "string") {
+      (0, _group2.default)(message.group).var(message.name).set(message.value);
+    } else {
+      var_(message.name).set(message.value);
+    }
+  });
+}
+
+var crosstalk = {
+  group: _group2.default,
+  var: var_,
+  has: has,
+  SelectionHandle: _selection.SelectionHandle,
+  FilterHandle: _filter.FilterHandle,
+  bind: _input.bind
+};
+
+/**
+ * @namespace crosstalk
+ */
+exports.default = crosstalk;
+
+global.crosstalk = crosstalk;
+
+}).call(this,typeof global !== "undefined" ? global : typeof self !== "undefined" ? self : typeof window !== "undefined" ? window : {})
+
+},{"./filter":2,"./group":4,"./input":6,"./input_checkboxgroup":7,"./input_selectize":8,"./input_slider":9,"./selection":10}],6:[function(require,module,exports){
+(function (global){
+"use strict";
+
+Object.defineProperty(exports, "__esModule", {
+  value: true
+});
+exports.register = register;
+exports.bind = bind;
+var $ = global.jQuery;
+
+var bindings = {};
+
+function register(reg) {
+  bindings[reg.className] = reg;
+  if (global.document && global.document.readyState !== "complete") {
+    $(function () {
+      bind();
+    });
+  } else if (global.document) {
+    setTimeout(bind, 100);
+  }
+}
+
+function bind() {
+  Object.keys(bindings).forEach(function (className) {
+    var binding = bindings[className];
+    $("." + binding.className).not(".crosstalk-input-bound").each(function (i, el) {
+      bindInstance(binding, el);
+    });
+  });
+}
+
+// Escape jQuery identifier
+function $escape(val) {
+  return val.replace(/([!"#$%&'()*+,./:;<=>?@[\\\]^`{|}~])/g, "\\$1");
+}
+
+function bindEl(el) {
+  var $el = $(el);
+  Object.keys(bindings).forEach(function (className) {
+    if ($el.hasClass(className) && !$el.hasClass("crosstalk-input-bound")) {
+      var binding = bindings[className];
+      bindInstance(binding, el);
+    }
+  });
+}
+
+function bindInstance(binding, el) {
+  var jsonEl = $(el).find("script[type='application/json'][data-for='" + $escape(el.id) + "']");
+  var data = JSON.parse(jsonEl[0].innerText);
+
+  var instance = binding.factory(el, data);
+  $(el).data("crosstalk-instance", instance);
+  $(el).addClass("crosstalk-input-bound");
+}
+
+if (global.Shiny) {
+  var inputBinding = new global.Shiny.InputBinding();
+  var _$ = global.jQuery;
+  _$.extend(inputBinding, {
+    find: function find(scope) {
+      return _$(scope).find(".crosstalk-input");
+    },
+    initialize: function initialize(el) {
+      if (!_$(el).hasClass("crosstalk-input-bound")) {
+        bindEl(el);
+      }
+    },
+    getId: function getId(el) {
+      return el.id;
+    },
+    getValue: function getValue(el) {},
+    setValue: function setValue(el, value) {},
+    receiveMessage: function receiveMessage(el, data) {},
+    subscribe: function subscribe(el, callback) {
+      _$(el).data("crosstalk-instance").resume();
+    },
+    unsubscribe: function unsubscribe(el) {
+      _$(el).data("crosstalk-instance").suspend();
+    }
+  });
+  global.Shiny.inputBindings.register(inputBinding, "crosstalk.inputBinding");
+}
+
+}).call(this,typeof global !== "undefined" ? global : typeof self !== "undefined" ? self : typeof window !== "undefined" ? window : {})
+
+},{}],7:[function(require,module,exports){
+(function (global){
+"use strict";
+
+var _input = require("./input");
+
+var input = _interopRequireWildcard(_input);
+
+var _filter = require("./filter");
+
+function _interopRequireWildcard(obj) { if (obj && obj.__esModule) { return obj; } else { var newObj = {}; if (obj != null) { for (var key in obj) { if (Object.prototype.hasOwnProperty.call(obj, key)) newObj[key] = obj[key]; } } newObj.default = obj; return newObj; } }
+
+var $ = global.jQuery;
+
+input.register({
+  className: "crosstalk-input-checkboxgroup",
+
+  factory: function factory(el, data) {
+    /*
+     * map: {"groupA": ["keyA", "keyB", ...], ...}
+     * group: "ct-groupname"
+     */
+    var ctHandle = new _filter.FilterHandle(data.group);
+
+    var lastKnownKeys = void 0;
+    var $el = $(el);
+    $el.on("change", "input[type='checkbox']", function () {
+      var checked = $el.find("input[type='checkbox']:checked");
+      if (checked.length === 0) {
+        lastKnownKeys = null;
+        ctHandle.clear();
+      } else {
+        var keys = {};
+        checked.each(function () {
+          data.map[this.value].forEach(function (key) {
+            keys[key] = true;
+          });
+        });
+        var keyArray = Object.keys(keys);
+        keyArray.sort();
+        lastKnownKeys = keyArray;
+        ctHandle.set(keyArray);
+      }
+    });
+
+    return {
+      suspend: function suspend() {
+        ctHandle.clear();
+      },
+      resume: function resume() {
+        if (lastKnownKeys) ctHandle.set(lastKnownKeys);
+      }
+    };
+  }
+});
+
+}).call(this,typeof global !== "undefined" ? global : typeof self !== "undefined" ? self : typeof window !== "undefined" ? window : {})
+
+},{"./filter":2,"./input":6}],8:[function(require,module,exports){
+(function (global){
+"use strict";
+
+var _input = require("./input");
+
+var input = _interopRequireWildcard(_input);
+
+var _util = require("./util");
+
+var util = _interopRequireWildcard(_util);
+
+var _filter = require("./filter");
+
+function _interopRequireWildcard(obj) { if (obj && obj.__esModule) { return obj; } else { var newObj = {}; if (obj != null) { for (var key in obj) { if (Object.prototype.hasOwnProperty.call(obj, key)) newObj[key] = obj[key]; } } newObj.default = obj; return newObj; } }
+
+var $ = global.jQuery;
+
+input.register({
+  className: "crosstalk-input-select",
+
+  factory: function factory(el, data) {
+    /*
+     * items: {value: [...], label: [...]}
+     * map: {"groupA": ["keyA", "keyB", ...], ...}
+     * group: "ct-groupname"
+     */
+
+    var first = [{ value: "", label: "(All)" }];
+    var items = util.dataframeToD3(data.items);
+    var opts = {
+      options: first.concat(items),
+      valueField: "value",
+      labelField: "label",
+      searchField: "label"
+    };
+
+    var select = $(el).find("select")[0];
+
+    var selectize = $(select).selectize(opts)[0].selectize;
+
+    var ctHandle = new _filter.FilterHandle(data.group);
+
+    var lastKnownKeys = void 0;
+    selectize.on("change", function () {
+      if (selectize.items.length === 0) {
+        lastKnownKeys = null;
+        ctHandle.clear();
+      } else {
+        var keys = {};
+        selectize.items.forEach(function (group) {
+          data.map[group].forEach(function (key) {
+            keys[key] = true;
+          });
+        });
+        var keyArray = Object.keys(keys);
+        keyArray.sort();
+        lastKnownKeys = keyArray;
+        ctHandle.set(keyArray);
+      }
+    });
+
+    return {
+      suspend: function suspend() {
+        ctHandle.clear();
+      },
+      resume: function resume() {
+        if (lastKnownKeys) ctHandle.set(lastKnownKeys);
+      }
+    };
+  }
+});
+
+}).call(this,typeof global !== "undefined" ? global : typeof self !== "undefined" ? self : typeof window !== "undefined" ? window : {})
+
+},{"./filter":2,"./input":6,"./util":11}],9:[function(require,module,exports){
+(function (global){
+"use strict";
+
+var _slicedToArray = function () { function sliceIterator(arr, i) { var _arr = []; var _n = true; var _d = false; var _e = undefined; try { for (var _i = arr[Symbol.iterator](), _s; !(_n = (_s = _i.next()).done); _n = true) { _arr.push(_s.value); if (i && _arr.length === i) break; } } catch (err) { _d = true; _e = err; } finally { try { if (!_n && _i["return"]) _i["return"](); } finally { if (_d) throw _e; } } return _arr; } return function (arr, i) { if (Array.isArray(arr)) { return arr; } else if (Symbol.iterator in Object(arr)) { return sliceIterator(arr, i); } else { throw new TypeError("Invalid attempt to destructure non-iterable instance"); } }; }();
+
+var _input = require("./input");
+
+var input = _interopRequireWildcard(_input);
+
+var _filter = require("./filter");
+
+function _interopRequireWildcard(obj) { if (obj && obj.__esModule) { return obj; } else { var newObj = {}; if (obj != null) { for (var key in obj) { if (Object.prototype.hasOwnProperty.call(obj, key)) newObj[key] = obj[key]; } } newObj.default = obj; return newObj; } }
+
+var $ = global.jQuery;
+var strftime = global.strftime;
+
+input.register({
+  className: "crosstalk-input-slider",
+
+  factory: function factory(el, data) {
+    /*
+     * map: {"groupA": ["keyA", "keyB", ...], ...}
+     * group: "ct-groupname"
+     */
+    var ctHandle = new _filter.FilterHandle(data.group);
+
+    var opts = {};
+    var $el = $(el).find("input");
+    var dataType = $el.data("data-type");
+    var timeFormat = $el.data("time-format");
+    var round = $el.data("round");
+    var timeFormatter = void 0;
+
+    // Set up formatting functions
+    if (dataType === "date") {
+      timeFormatter = strftime.utc();
+      opts.prettify = function (num) {
+        return timeFormatter(timeFormat, new Date(num));
+      };
+    } else if (dataType === "datetime") {
+      var timezone = $el.data("timezone");
+      if (timezone) timeFormatter = strftime.timezone(timezone);else timeFormatter = strftime;
+
+      opts.prettify = function (num) {
+        return timeFormatter(timeFormat, new Date(num));
+      };
+    } else if (dataType === "number") {
+      if (typeof round !== "undefined") opts.prettify = function (num) {
+        var factor = Math.pow(10, round);
+        return Math.round(num * factor) / factor;
+      };
+    }
+
+    $el.ionRangeSlider(opts);
+
+    function getValue() {
+      var result = $el.data("ionRangeSlider").result;
+
+      // Function for converting numeric value from slider to appropriate type.
+      var convert = void 0;
+      var dataType = $el.data("data-type");
+      if (dataType === "date") {
+        convert = function convert(val) {
+          return formatDateUTC(new Date(+val));
+        };
+      } else if (dataType === "datetime") {
+        convert = function convert(val) {
+          // Convert ms to s
+          return +val / 1000;
+        };
+      } else {
+        convert = function convert(val) {
+          return +val;
+        };
+      }
+
+      if ($el.data("ionRangeSlider").options.type === "double") {
+        return [convert(result.from), convert(result.to)];
+      } else {
+        return convert(result.from);
+      }
+    }
+
+    var lastKnownKeys = null;
+
+    $el.on("change.crosstalkSliderInput", function (event) {
+      if (!$el.data("updating") && !$el.data("animating")) {
+        var _getValue = getValue(),
+            _getValue2 = _slicedToArray(_getValue, 2),
+            from = _getValue2[0],
+            to = _getValue2[1];
+
+        var keys = [];
+        for (var i = 0; i < data.values.length; i++) {
+          var val = data.values[i];
+          if (val >= from && val <= to) {
+            keys.push(data.keys[i]);
+          }
+        }
+        keys.sort();
+        ctHandle.set(keys);
+        lastKnownKeys = keys;
+      }
+    });
+
+    // let $el = $(el);
+    // $el.on("change", "input[type="checkbox"]", function() {
+    //   let checked = $el.find("input[type="checkbox"]:checked");
+    //   if (checked.length === 0) {
+    //     ctHandle.clear();
+    //   } else {
+    //     let keys = {};
+    //     checked.each(function() {
+    //       data.map[this.value].forEach(function(key) {
+    //         keys[key] = true;
+    //       });
+    //     });
+    //     let keyArray = Object.keys(keys);
+    //     keyArray.sort();
+    //     ctHandle.set(keyArray);
+    //   }
+    // });
+
+    return {
+      suspend: function suspend() {
+        ctHandle.clear();
+      },
+      resume: function resume() {
+        if (lastKnownKeys) ctHandle.set(lastKnownKeys);
+      }
+    };
+  }
+});
+
+// Convert a number to a string with leading zeros
+function padZeros(n, digits) {
+  var str = n.toString();
+  while (str.length < digits) {
+    str = "0" + str;
+  }return str;
+}
+
+// Given a Date object, return a string in yyyy-mm-dd format, using the
+// UTC date. This may be a day off from the date in the local time zone.
+function formatDateUTC(date) {
+  if (date instanceof Date) {
+    return date.getUTCFullYear() + "-" + padZeros(date.getUTCMonth() + 1, 2) + "-" + padZeros(date.getUTCDate(), 2);
+  } else {
+    return null;
+  }
+}
+
+}).call(this,typeof global !== "undefined" ? global : typeof self !== "undefined" ? self : typeof window !== "undefined" ? window : {})
+
+},{"./filter":2,"./input":6}],10:[function(require,module,exports){
+"use strict";
+
+Object.defineProperty(exports, "__esModule", {
+  value: true
+});
+exports.SelectionHandle = undefined;
+
+var _createClass = function () { function defineProperties(target, props) { for (var i = 0; i < props.length; i++) { var descriptor = props[i]; descriptor.enumerable = descriptor.enumerable || false; descriptor.configurable = true; if ("value" in descriptor) descriptor.writable = true; Object.defineProperty(target, descriptor.key, descriptor); } } return function (Constructor, protoProps, staticProps) { if (protoProps) defineProperties(Constructor.prototype, protoProps); if (staticProps) defineProperties(Constructor, staticProps); return Constructor; }; }();
+
+var _events = require("./events");
+
+var _events2 = _interopRequireDefault(_events);
+
+var _group = require("./group");
+
+var _group2 = _interopRequireDefault(_group);
+
+var _util = require("./util");
+
+var util = _interopRequireWildcard(_util);
+
+function _interopRequireWildcard(obj) { if (obj && obj.__esModule) { return obj; } else { var newObj = {}; if (obj != null) { for (var key in obj) { if (Object.prototype.hasOwnProperty.call(obj, key)) newObj[key] = obj[key]; } } newObj.default = obj; return newObj; } }
+
+function _interopRequireDefault(obj) { return obj && obj.__esModule ? obj : { default: obj }; }
+
+function _classCallCheck(instance, Constructor) { if (!(instance instanceof Constructor)) { throw new TypeError("Cannot call a class as a function"); } }
+
+/**
+ * Use this class to read and write (and listen for changes to) the selection
+ * for a Crosstalk group. This is intended to be used for linked brushing.
+ *
+ * If two (or more) `SelectionHandle` instances in the same webpage share the
+ * same group name, they will share the same state. Setting the selection using
+ * one `SelectionHandle` instance will result in the `value` property instantly
+ * changing across the others, and `"change"` event listeners on all instances
+ * (including the one that initiated the sending) will fire.
+ *
+ * @param {string} [group] - The name of the Crosstalk group, or if none,
+ *   null or undefined (or any other falsy value). This can be changed later
+ *   via the [SelectionHandle#setGroup](#setGroup) method.
+ * @param {Object} [extraInfo] - An object whose properties will be copied to
+ *   the event object whenever an event is emitted.
+ */
+var SelectionHandle = exports.SelectionHandle = function () {
+  function SelectionHandle() {
+    var group = arguments.length > 0 && arguments[0] !== undefined ? arguments[0] : null;
+    var extraInfo = arguments.length > 1 && arguments[1] !== undefined ? arguments[1] : null;
+
+    _classCallCheck(this, SelectionHandle);
+
+    this._eventRelay = new _events2.default();
+    this._emitter = new util.SubscriptionTracker(this._eventRelay);
+
+    // Name of the group we're currently tracking, if any. Can change over time.
+    this._group = null;
+    // The Var we're currently tracking, if any. Can change over time.
+    this._var = null;
+    // The event handler subscription we currently have on var.on("change").
+    this._varOnChangeSub = null;
+
+    this._extraInfo = util.extend({ sender: this }, extraInfo);
+
+    this.setGroup(group);
+  }
+
+  /**
+   * Changes the Crosstalk group membership of this SelectionHandle. The group
+   * being switched away from (if any) will not have its selection value
+   * modified as a result of calling `setGroup`, even if this handle was the
+   * most recent handle to set the selection of the group.
+   *
+   * The group being switched to (if any) will also not have its selection value
+   * modified as a result of calling `setGroup`. If you want to set the
+   * selection value of the new group, call `set` explicitly.
+   *
+   * @param {string} group - The name of the Crosstalk group, or null (or
+   *   undefined) to clear the group.
+   */
+
+
+  _createClass(SelectionHandle, [{
+    key: "setGroup",
+    value: function setGroup(group) {
+      var _this = this;
+
+      // If group is unchanged, do nothing
+      if (this._group === group) return;
+      // Treat null, undefined, and other falsy values the same
+      if (!this._group && !group) return;
+
+      if (this._var) {
+        this._var.off("change", this._varOnChangeSub);
+        this._var = null;
+        this._varOnChangeSub = null;
+      }
+
+      this._group = group;
+
+      if (group) {
+        this._var = (0, _group2.default)(group).var("selection");
+        var sub = this._var.on("change", function (e) {
+          _this._eventRelay.trigger("change", e, _this);
+        });
+        this._varOnChangeSub = sub;
+      }
+    }
+
+    /**
+     * Retrieves the current selection for the group represented by this
+     * `SelectionHandle`.
+     *
+     * - If no selection is active, then this value will be falsy.
+     * - If a selection is active, but no data points are selected, then this
+     *   value will be an empty array.
+     * - If a selection is active, and data points are selected, then the keys
+     *   of the selected data points will be present in the array.
+     */
+
+  }, {
+    key: "_mergeExtraInfo",
+
+
+    /**
+     * Combines the given `extraInfo` (if any) with the handle's default
+     * `_extraInfo` (if any).
+     * @private
+     */
+    value: function _mergeExtraInfo(extraInfo) {
+      // Important incidental effect: shallow clone is returned
+      return util.extend({}, this._extraInfo ? this._extraInfo : null, extraInfo ? extraInfo : null);
+    }
+
+    /**
+     * Overwrites the current selection for the group, and raises the `"change"`
+     * event among all of the group's '`SelectionHandle` instances (including
+     * this one).
+     *
+     * @fires SelectionHandle#change
+     * @param {string[]} selectedKeys - Falsy, empty array, or array of keys (see
+     *   {@link SelectionHandle#value}).
+     * @param {Object} [extraInfo] - Extra properties to be included on the event
+     *   object that's passed to listeners (in addition to any options that were
+     *   passed into the `SelectionHandle` constructor).
+     */
+
+  }, {
+    key: "set",
+    value: function set(selectedKeys, extraInfo) {
+      if (this._var) this._var.set(selectedKeys, this._mergeExtraInfo(extraInfo));
+    }
+
+    /**
+     * Overwrites the current selection for the group, and raises the `"change"`
+     * event among all of the group's '`SelectionHandle` instances (including
+     * this one).
+     *
+     * @fires SelectionHandle#change
+     * @param {Object} [extraInfo] - Extra properties to be included on the event
+     *   object that's passed to listeners (in addition to any that were passed
+     *   into the `SelectionHandle` constructor).
+     */
+
+  }, {
+    key: "clear",
+    value: function clear(extraInfo) {
+      if (this._var) this.set(void 0, this._mergeExtraInfo(extraInfo));
+    }
+
+    /**
+     * Subscribes to events on this `SelectionHandle`.
+     *
+     * @param {string} eventType - Indicates the type of events to listen to.
+     *   Currently, only `"change"` is supported.
+     * @param {SelectionHandle~listener} listener - The callback function that
+     *   will be invoked when the event occurs.
+     * @return {string} - A token to pass to {@link SelectionHandle#off} to cancel
+     *   this subscription.
+     */
+
+  }, {
+    key: "on",
+    value: function on(eventType, listener) {
+      return this._emitter.on(eventType, listener);
+    }
+
+    /**
+     * Cancels event subscriptions created by {@link SelectionHandle#on}.
+     *
+     * @param {string} eventType - The type of event to unsubscribe.
+     * @param {string|SelectionHandle~listener} listener - Either the callback
+     *   function previously passed into {@link SelectionHandle#on}, or the
+     *   string that was returned from {@link SelectionHandle#on}.
+     */
+
+  }, {
+    key: "off",
+    value: function off(eventType, listener) {
+      return this._emitter.off(eventType, listener);
+    }
+
+    /**
+     * Shuts down the `SelectionHandle` object.
+     *
+     * Removes all event listeners that were added through this handle.
+     */
+
+  }, {
+    key: "close",
+    value: function close() {
+      this._emitter.removeAllListeners();
+      this.setGroup(null);
+    }
+  }, {
+    key: "value",
+    get: function get() {
+      return this._var ? this._var.get() : null;
+    }
+  }]);
+
+  return SelectionHandle;
+}();
+
+/**
+ * @callback SelectionHandle~listener
+ * @param {Object} event - An object containing details of the event. For
+ *   `"change"` events, this includes the properties `value` (the new
+ *   value of the selection, or `undefined` if no selection is active),
+ *   `oldValue` (the previous value of the selection), and `sender` (the
+ *   `SelectionHandle` instance that made the change).
+ */
+
+/**
+ * @event SelectionHandle#change
+ * @type {object}
+ * @property {object} value - The new value of the selection, or `undefined`
+ *   if no selection is active.
+ * @property {object} oldValue - The previous value of the selection.
+ * @property {SelectionHandle} sender - The `SelectionHandle` instance that
+ *   changed the value.
+ */
+
+},{"./events":1,"./group":4,"./util":11}],11:[function(require,module,exports){
+"use strict";
+
+Object.defineProperty(exports, "__esModule", {
+  value: true
+});
+
+var _createClass = function () { function defineProperties(target, props) { for (var i = 0; i < props.length; i++) { var descriptor = props[i]; descriptor.enumerable = descriptor.enumerable || false; descriptor.configurable = true; if ("value" in descriptor) descriptor.writable = true; Object.defineProperty(target, descriptor.key, descriptor); } } return function (Constructor, protoProps, staticProps) { if (protoProps) defineProperties(Constructor.prototype, protoProps); if (staticProps) defineProperties(Constructor, staticProps); return Constructor; }; }();
+
+var _typeof = typeof Symbol === "function" && typeof Symbol.iterator === "symbol" ? function (obj) { return typeof obj; } : function (obj) { return obj && typeof Symbol === "function" && obj.constructor === Symbol && obj !== Symbol.prototype ? "symbol" : typeof obj; };
+
+exports.extend = extend;
+exports.checkSorted = checkSorted;
+exports.diffSortedLists = diffSortedLists;
+exports.dataframeToD3 = dataframeToD3;
+
+function _classCallCheck(instance, Constructor) { if (!(instance instanceof Constructor)) { throw new TypeError("Cannot call a class as a function"); } }
+
+function extend(target) {
+  for (var _len = arguments.length, sources = Array(_len > 1 ? _len - 1 : 0), _key = 1; _key < _len; _key++) {
+    sources[_key - 1] = arguments[_key];
+  }
+
+  for (var i = 0; i < sources.length; i++) {
+    var src = sources[i];
+    if (typeof src === "undefined" || src === null) continue;
+
+    for (var key in src) {
+      if (src.hasOwnProperty(key)) {
+        target[key] = src[key];
+      }
+    }
+  }
+  return target;
+}
+
+function checkSorted(list) {
+  for (var i = 1; i < list.length; i++) {
+    if (list[i] <= list[i - 1]) {
+      throw new Error("List is not sorted or contains duplicate");
+    }
+  }
+}
+
+function diffSortedLists(a, b) {
+  var i_a = 0;
+  var i_b = 0;
+
+  if (!a) a = [];
+  if (!b) b = [];
+
+  var a_only = [];
+  var b_only = [];
+
+  checkSorted(a);
+  checkSorted(b);
+
+  while (i_a < a.length && i_b < b.length) {
+    if (a[i_a] === b[i_b]) {
+      i_a++;
+      i_b++;
+    } else if (a[i_a] < b[i_b]) {
+      a_only.push(a[i_a++]);
+    } else {
+      b_only.push(b[i_b++]);
+    }
+  }
+
+  if (i_a < a.length) a_only = a_only.concat(a.slice(i_a));
+  if (i_b < b.length) b_only = b_only.concat(b.slice(i_b));
+  return {
+    removed: a_only,
+    added: b_only
+  };
+}
+
+// Convert from wide: { colA: [1,2,3], colB: [4,5,6], ... }
+// to long: [ {colA: 1, colB: 4}, {colA: 2, colB: 5}, ... ]
+function dataframeToD3(df) {
+  var names = [];
+  var length = void 0;
+  for (var name in df) {
+    if (df.hasOwnProperty(name)) names.push(name);
+    if (_typeof(df[name]) !== "object" || typeof df[name].length === "undefined") {
+      throw new Error("All fields must be arrays");
+    } else if (typeof length !== "undefined" && length !== df[name].length) {
+      throw new Error("All fields must be arrays of the same length");
+    }
+    length = df[name].length;
+  }
+  var results = [];
+  var item = void 0;
+  for (var row = 0; row < length; row++) {
+    item = {};
+    for (var col = 0; col < names.length; col++) {
+      item[names[col]] = df[names[col]][row];
+    }
+    results.push(item);
+  }
+  return results;
+}
+
+/**
+ * Keeps track of all event listener additions/removals and lets all active
+ * listeners be removed with a single operation.
+ *
+ * @private
+ */
+
+var SubscriptionTracker = exports.SubscriptionTracker = function () {
+  function SubscriptionTracker(emitter) {
+    _classCallCheck(this, SubscriptionTracker);
+
+    this._emitter = emitter;
+    this._subs = {};
+  }
+
+  _createClass(SubscriptionTracker, [{
+    key: "on",
+    value: function on(eventType, listener) {
+      var sub = this._emitter.on(eventType, listener);
+      this._subs[sub] = eventType;
+      return sub;
+    }
+  }, {
+    key: "off",
+    value: function off(eventType, listener) {
+      var sub = this._emitter.off(eventType, listener);
+      if (sub) {
+        delete this._subs[sub];
+      }
+      return sub;
+    }
+  }, {
+    key: "removeAllListeners",
+    value: function removeAllListeners() {
+      var _this = this;
+
+      var current_subs = this._subs;
+      this._subs = {};
+      Object.keys(current_subs).forEach(function (sub) {
+        _this._emitter.off(current_subs[sub], sub);
+      });
+    }
+  }]);
+
+  return SubscriptionTracker;
+}();
+
+},{}],12:[function(require,module,exports){
+(function (global){
+"use strict";
+
+Object.defineProperty(exports, "__esModule", {
+  value: true
+});
+
+var _typeof = typeof Symbol === "function" && typeof Symbol.iterator === "symbol" ? function (obj) { return typeof obj; } : function (obj) { return obj && typeof Symbol === "function" && obj.constructor === Symbol && obj !== Symbol.prototype ? "symbol" : typeof obj; };
+
+var _createClass = function () { function defineProperties(target, props) { for (var i = 0; i < props.length; i++) { var descriptor = props[i]; descriptor.enumerable = descriptor.enumerable || false; descriptor.configurable = true; if ("value" in descriptor) descriptor.writable = true; Object.defineProperty(target, descriptor.key, descriptor); } } return function (Constructor, protoProps, staticProps) { if (protoProps) defineProperties(Constructor.prototype, protoProps); if (staticProps) defineProperties(Constructor, staticProps); return Constructor; }; }();
+
+var _events = require("./events");
+
+var _events2 = _interopRequireDefault(_events);
+
+function _interopRequireDefault(obj) { return obj && obj.__esModule ? obj : { default: obj }; }
+
+function _classCallCheck(instance, Constructor) { if (!(instance instanceof Constructor)) { throw new TypeError("Cannot call a class as a function"); } }
+
+var Var = function () {
+  function Var(group, name, /*optional*/value) {
+    _classCallCheck(this, Var);
+
+    this._group = group;
+    this._name = name;
+    this._value = value;
+    this._events = new _events2.default();
+  }
+
+  _createClass(Var, [{
+    key: "get",
+    value: function get() {
+      return this._value;
+    }
+  }, {
+    key: "set",
+    value: function set(value, /*optional*/event) {
+      if (this._value === value) {
+        // Do nothing; the value hasn't changed
+        return;
+      }
+      var oldValue = this._value;
+      this._value = value;
+      // Alert JavaScript listeners that the value has changed
+      var evt = {};
+      if (event && (typeof event === "undefined" ? "undefined" : _typeof(event)) === "object") {
+        for (var k in event) {
+          if (event.hasOwnProperty(k)) evt[k] = event[k];
+        }
+      }
+      evt.oldValue = oldValue;
+      evt.value = value;
+      this._events.trigger("change", evt, this);
+
+      // TODO: Make this extensible, to let arbitrary back-ends know that
+      // something has changed
+      if (global.Shiny && global.Shiny.onInputChange) {
+        global.Shiny.onInputChange(".clientValue-" + (this._group.name !== null ? this._group.name + "-" : "") + this._name, typeof value === "undefined" ? null : value);
+      }
+    }
+  }, {
+    key: "on",
+    value: function on(eventType, listener) {
+      return this._events.on(eventType, listener);
+    }
+  }, {
+    key: "off",
+    value: function off(eventType, listener) {
+      return this._events.off(eventType, listener);
+    }
+  }]);
+
+  return Var;
+}();
+
+exports.default = Var;
+
+}).call(this,typeof global !== "undefined" ? global : typeof self !== "undefined" ? self : typeof window !== "undefined" ? window : {})
+
+},{"./events":1}]},{},[5])
+//# sourceMappingURL=crosstalk.js.map
diff --git a/articles/rxode2-model-types_files/crosstalk-1.2.1/js/crosstalk.js.map b/articles/rxode2-model-types_files/crosstalk-1.2.1/js/crosstalk.js.map
new file mode 100644
index 000000000..cff94f089
--- /dev/null
+++ b/articles/rxode2-model-types_files/crosstalk-1.2.1/js/crosstalk.js.map
@@ -0,0 +1,37 @@
+{
+  "version": 3,
+  "sources": [
+    "node_modules/browser-pack/_prelude.js",
+    "javascript/src/events.js",
+    "javascript/src/filter.js",
+    "javascript/src/filterset.js",
+    "javascript/src/group.js",
+    "javascript/src/index.js",
+    "javascript/src/input.js",
+    "javascript/src/input_checkboxgroup.js",
+    "javascript/src/input_selectize.js",
+    "javascript/src/input_slider.js",
+    "javascript/src/selection.js",
+    "javascript/src/util.js",
+    "javascript/src/var.js"
+  ],
+  "names": [],
+  "mappings": 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+  "sourceRoot": "",
+  "sourcesContent": [
+    "(function(){function e(t,n,r){function s(o,u){if(!n[o]){if(!t[o]){var a=typeof require==\"function\"&&require;if(!u&&a)return a(o,!0);if(i)return i(o,!0);var f=new Error(\"Cannot find module '\"+o+\"'\");throw f.code=\"MODULE_NOT_FOUND\",f}var l=n[o]={exports:{}};t[o][0].call(l.exports,function(e){var n=t[o][1][e];return s(n?n:e)},l,l.exports,e,t,n,r)}return n[o].exports}var i=typeof require==\"function\"&&require;for(var o=0;o {\n        this._eventRelay.trigger(\"change\", e, this);\n      });\n      this._varOnChangeSub = sub;\n    }\n  }\n\n  /**\n   * Combine the given `extraInfo` (if any) with the handle's default\n   * `_extraInfo` (if any).\n   * @private\n   */\n  _mergeExtraInfo(extraInfo) {\n    return util.extend({},\n      this._extraInfo ? this._extraInfo : null,\n      extraInfo ? extraInfo : null);\n  }\n\n  /**\n   * Close the handle. This clears this handle's contribution to the filter set,\n   * and unsubscribes all event listeners.\n   */\n  close() {\n    this._emitter.removeAllListeners();\n    this.clear();\n    this.setGroup(null);\n  }\n\n  /**\n   * Clear this handle's contribution to the filter set.\n   *\n   * @param {Object} [extraInfo] - Extra properties to be included on the event\n   *   object that's passed to listeners (in addition to any options that were\n   *   passed into the `FilterHandle` constructor).\n   * \n   * @fires FilterHandle#change\n   */\n  clear(extraInfo) {\n    if (!this._filterSet)\n      return;\n    this._filterSet.clear(this._id);\n    this._onChange(extraInfo);\n  }\n\n  /**\n   * Set this handle's contribution to the filter set. This array should consist\n   * of the keys of the rows that _should_ be displayed; any keys that are not\n   * present in the array will be considered _filtered out_. Note that multiple\n   * `FilterHandle` instances in the group may each contribute an array of keys,\n   * and only those keys that appear in _all_ of the arrays make it through the\n   * filter.\n   *\n   * @param {string[]} keys - Empty array, or array of keys. To clear the\n   *   filter, don't pass an empty array; instead, use the\n   *   {@link FilterHandle#clear} method.\n   * @param {Object} [extraInfo] - Extra properties to be included on the event\n   *   object that's passed to listeners (in addition to any options that were\n   *   passed into the `FilterHandle` constructor).\n   * \n   * @fires FilterHandle#change\n   */\n  set(keys, extraInfo) {\n    if (!this._filterSet)\n      return;\n    this._filterSet.update(this._id, keys);\n    this._onChange(extraInfo);\n  }\n\n  /**\n   * @return {string[]|null} - Either: 1) an array of keys that made it through\n   *   all of the `FilterHandle` instances, or, 2) `null`, which means no filter\n   *   is being applied (all data should be displayed).\n   */\n  get filteredKeys() {\n    return this._filterSet ? this._filterSet.value : null;\n  }\n\n  /**\n   * Subscribe to events on this `FilterHandle`.\n   *\n   * @param {string} eventType - Indicates the type of events to listen to.\n   *   Currently, only `\"change\"` is supported.\n   * @param {FilterHandle~listener} listener - The callback function that\n   *   will be invoked when the event occurs.\n   * @return {string} - A token to pass to {@link FilterHandle#off} to cancel\n   *   this subscription.\n   */\n  on(eventType, listener) {\n    return this._emitter.on(eventType, listener);\n  }\n\n  /**\n   * Cancel event subscriptions created by {@link FilterHandle#on}.\n   *\n   * @param {string} eventType - The type of event to unsubscribe.\n   * @param {string|FilterHandle~listener} listener - Either the callback\n   *   function previously passed into {@link FilterHandle#on}, or the\n   *   string that was returned from {@link FilterHandle#on}.\n   */\n  off(eventType, listener) {\n    return this._emitter.off(eventType, listener);\n  }\n\n  _onChange(extraInfo) {\n    if (!this._filterSet)\n      return;\n    this._filterVar.set(this._filterSet.value, this._mergeExtraInfo(extraInfo));\n  }\n\n  /**\n   * @callback FilterHandle~listener\n   * @param {Object} event - An object containing details of the event. For\n   *   `\"change\"` events, this includes the properties `value` (the new\n   *   value of the filter set, or `null` if no filter set is active),\n   *   `oldValue` (the previous value of the filter set), and `sender` (the\n   *   `FilterHandle` instance that made the change).\n   */\n\n}\n\n/**\n * @event FilterHandle#change\n * @type {object}\n * @property {object} value - The new value of the filter set, or `null`\n *   if no filter set is active.\n * @property {object} oldValue - The previous value of the filter set.\n * @property {FilterHandle} sender - The `FilterHandle` instance that\n *   changed the value.\n */\n",
+    "import { diffSortedLists } from \"./util\";\n\nfunction naturalComparator(a, b) {\n  if (a === b) {\n    return 0;\n  } else if (a < b) {\n    return -1;\n  } else if (a > b) {\n    return 1;\n  }\n}\n\n/**\n * @private\n */\nexport default class FilterSet {\n  constructor() {\n    this.reset();\n  }\n\n  reset() {\n    // Key: handle ID, Value: array of selected keys, or null\n    this._handles = {};\n    // Key: key string, Value: count of handles that include it\n    this._keys = {};\n    this._value = null;\n    this._activeHandles = 0;\n  }\n\n  get value() {\n    return this._value;\n  }\n\n  update(handleId, keys) {\n    if (keys !== null) {\n      keys = keys.slice(0); // clone before sorting\n      keys.sort(naturalComparator);\n    }\n\n    let {added, removed} = diffSortedLists(this._handles[handleId], keys);\n    this._handles[handleId] = keys;\n\n    for (let i = 0; i < added.length; i++) {\n      this._keys[added[i]] = (this._keys[added[i]] || 0) + 1;\n    }\n    for (let i = 0; i < removed.length; i++) {\n      this._keys[removed[i]]--;\n    }\n\n    this._updateValue(keys);\n  }\n\n  /**\n   * @param {string[]} keys Sorted array of strings that indicate\n   * a superset of possible keys.\n   * @private\n   */\n  _updateValue(keys = this._allKeys) {\n    let handleCount = Object.keys(this._handles).length;\n    if (handleCount === 0) {\n      this._value = null;\n    } else {\n      this._value = [];\n      for (let i = 0; i < keys.length; i++) {\n        let count = this._keys[keys[i]];\n        if (count === handleCount) {\n          this._value.push(keys[i]);\n        }\n      }\n    }\n  }\n\n  clear(handleId) {\n    if (typeof(this._handles[handleId]) === \"undefined\") {\n      return;\n    }\n\n    let keys = this._handles[handleId];\n    if (!keys) {\n      keys = [];\n    }\n\n    for (let i = 0; i < keys.length; i++) {\n      this._keys[keys[i]]--;\n    }\n    delete this._handles[handleId];\n\n    this._updateValue();\n  }\n\n  get _allKeys() {\n    let allKeys = Object.keys(this._keys);\n    allKeys.sort(naturalComparator);\n    return allKeys;\n  }\n}\n",
+    "import Var from \"./var\";\n\n// Use a global so that multiple copies of crosstalk.js can be loaded and still\n// have groups behave as singletons across all copies.\nglobal.__crosstalk_groups = global.__crosstalk_groups || {};\nlet groups = global.__crosstalk_groups;\n\nexport default function group(groupName) {\n  if (groupName && typeof(groupName) === \"string\") {\n    if (!groups.hasOwnProperty(groupName)) {\n      groups[groupName] = new Group(groupName);\n    }\n    return groups[groupName];\n  } else if (typeof(groupName) === \"object\" && groupName._vars && groupName.var) {\n    // Appears to already be a group object\n    return groupName;\n  } else if (Array.isArray(groupName) &&\n      groupName.length == 1 &&\n      typeof(groupName[0]) === \"string\") {\n    return group(groupName[0]);\n  } else {\n    throw new Error(\"Invalid groupName argument\");\n  }\n}\n\nclass Group {\n  constructor(name) {\n    this.name = name;\n    this._vars = {};\n  }\n\n  var(name) {\n    if (!name || typeof(name) !== \"string\") {\n      throw new Error(\"Invalid var name\");\n    }\n\n    if (!this._vars.hasOwnProperty(name))\n      this._vars[name] = new Var(this, name);\n    return this._vars[name];\n  }\n\n  has(name) {\n    if (!name || typeof(name) !== \"string\") {\n      throw new Error(\"Invalid var name\");\n    }\n\n    return this._vars.hasOwnProperty(name);\n  }\n}\n",
+    "import group from \"./group\";\nimport { SelectionHandle } from \"./selection\";\nimport { FilterHandle } from \"./filter\";\nimport { bind } from \"./input\";\nimport \"./input_selectize\";\nimport \"./input_checkboxgroup\";\nimport \"./input_slider\";\n\nconst defaultGroup = group(\"default\");\n\nfunction var_(name) {\n  return defaultGroup.var(name);\n}\n\nfunction has(name) {\n  return defaultGroup.has(name);\n}\n\nif (global.Shiny) {\n  global.Shiny.addCustomMessageHandler(\"update-client-value\", function(message) {\n    if (typeof(message.group) === \"string\") {\n      group(message.group).var(message.name).set(message.value);\n    } else {\n      var_(message.name).set(message.value);\n    }\n  });\n}\n\nconst crosstalk = {\n  group: group,\n  var: var_,\n  has: has,\n  SelectionHandle: SelectionHandle,\n  FilterHandle: FilterHandle,\n  bind: bind\n};\n\n/**\n * @namespace crosstalk\n */\nexport default crosstalk;\nglobal.crosstalk = crosstalk;\n",
+    "let $ = global.jQuery;\n\nlet bindings = {};\n\nexport function register(reg) {\n  bindings[reg.className] = reg;\n  if (global.document && global.document.readyState !== \"complete\") {\n    $(() => {\n      bind();\n    });\n  } else if (global.document) {\n    setTimeout(bind, 100);\n  }\n}\n\nexport function bind() {\n  Object.keys(bindings).forEach(function(className) {\n    let binding = bindings[className];\n    $(\".\" + binding.className).not(\".crosstalk-input-bound\").each(function(i, el) {\n      bindInstance(binding, el);\n    });\n  });\n}\n\n// Escape jQuery identifier\nfunction $escape(val) {\n  return val.replace(/([!\"#$%&'()*+,./:;<=>?@[\\\\\\]^`{|}~])/g, \"\\\\$1\");\n}\n\nfunction bindEl(el) {\n  let $el = $(el);\n  Object.keys(bindings).forEach(function(className) {\n    if ($el.hasClass(className) && !$el.hasClass(\"crosstalk-input-bound\")) {\n      let binding = bindings[className];\n      bindInstance(binding, el);\n    }\n  });\n}\n\nfunction bindInstance(binding, el) {\n  let jsonEl = $(el).find(\"script[type='application/json'][data-for='\" + $escape(el.id) + \"']\");\n  let data = JSON.parse(jsonEl[0].innerText);\n\n  let instance = binding.factory(el, data);\n  $(el).data(\"crosstalk-instance\", instance);\n  $(el).addClass(\"crosstalk-input-bound\");\n}\n\nif (global.Shiny) {\n  let inputBinding = new global.Shiny.InputBinding();\n  let $ = global.jQuery;\n  $.extend(inputBinding, {\n    find: function(scope) {\n      return $(scope).find(\".crosstalk-input\");\n    },\n    initialize: function(el) {\n      if (!$(el).hasClass(\"crosstalk-input-bound\")) {\n        bindEl(el);\n      }\n    },\n    getId: function(el) {\n      return el.id;\n    },\n    getValue: function(el) {\n\n    },\n    setValue: function(el, value) {\n\n    },\n    receiveMessage: function(el, data) {\n\n    },\n    subscribe: function(el, callback) {\n      $(el).data(\"crosstalk-instance\").resume();\n    },\n    unsubscribe: function(el) {\n      $(el).data(\"crosstalk-instance\").suspend();\n    }\n  });\n  global.Shiny.inputBindings.register(inputBinding, \"crosstalk.inputBinding\");\n}\n",
+    "import * as input from \"./input\";\nimport { FilterHandle } from \"./filter\";\n\nlet $ = global.jQuery;\n\ninput.register({\n  className: \"crosstalk-input-checkboxgroup\",\n\n  factory: function(el, data) {\n    /*\n     * map: {\"groupA\": [\"keyA\", \"keyB\", ...], ...}\n     * group: \"ct-groupname\"\n     */\n    let ctHandle = new FilterHandle(data.group);\n\n    let lastKnownKeys;\n    let $el = $(el);\n    $el.on(\"change\", \"input[type='checkbox']\", function() {\n      let checked = $el.find(\"input[type='checkbox']:checked\");\n      if (checked.length === 0) {\n        lastKnownKeys = null;\n        ctHandle.clear();\n      } else {\n        let keys = {};\n        checked.each(function() {\n          data.map[this.value].forEach(function(key) {\n            keys[key] = true;\n          });\n        });\n        let keyArray = Object.keys(keys);\n        keyArray.sort();\n        lastKnownKeys = keyArray;\n        ctHandle.set(keyArray);\n      }\n    });\n\n    return {\n      suspend: function() {\n        ctHandle.clear();\n      },\n      resume: function() {\n        if (lastKnownKeys)\n          ctHandle.set(lastKnownKeys);\n      }\n    };\n  }\n});\n",
+    "import * as input from \"./input\";\nimport * as util from \"./util\";\nimport { FilterHandle } from \"./filter\";\n\nlet $ = global.jQuery;\n\ninput.register({\n  className: \"crosstalk-input-select\",\n\n  factory: function(el, data) {\n    /*\n     * items: {value: [...], label: [...]}\n     * map: {\"groupA\": [\"keyA\", \"keyB\", ...], ...}\n     * group: \"ct-groupname\"\n     */\n\n    let first = [{value: \"\", label: \"(All)\"}];\n    let items = util.dataframeToD3(data.items);\n    let opts = {\n      options: first.concat(items),\n      valueField: \"value\",\n      labelField: \"label\",\n      searchField: \"label\"\n    };\n\n    let select = $(el).find(\"select\")[0];\n\n    let selectize = $(select).selectize(opts)[0].selectize;\n\n    let ctHandle = new FilterHandle(data.group);\n\n    let lastKnownKeys;\n    selectize.on(\"change\", function() {\n      if (selectize.items.length === 0) {\n        lastKnownKeys = null;\n        ctHandle.clear();\n      } else {\n        let keys = {};\n        selectize.items.forEach(function(group) {\n          data.map[group].forEach(function(key) {\n            keys[key] = true;\n          });\n        });\n        let keyArray = Object.keys(keys);\n        keyArray.sort();\n        lastKnownKeys = keyArray;\n        ctHandle.set(keyArray);\n      }\n    });\n\n    return {\n      suspend: function() {\n        ctHandle.clear();\n      },\n      resume: function() {\n        if (lastKnownKeys)\n          ctHandle.set(lastKnownKeys);\n      }\n    };\n  }\n});\n",
+    "import * as input from \"./input\";\nimport { FilterHandle } from \"./filter\";\n\nlet $ = global.jQuery;\nlet strftime = global.strftime;\n\ninput.register({\n  className: \"crosstalk-input-slider\",\n\n  factory: function(el, data) {\n    /*\n     * map: {\"groupA\": [\"keyA\", \"keyB\", ...], ...}\n     * group: \"ct-groupname\"\n     */\n    let ctHandle = new FilterHandle(data.group);\n\n    let opts = {};\n    let $el = $(el).find(\"input\");\n    let dataType = $el.data(\"data-type\");\n    let timeFormat = $el.data(\"time-format\");\n    let round = $el.data(\"round\");\n    let timeFormatter;\n\n    // Set up formatting functions\n    if (dataType === \"date\") {\n      timeFormatter = strftime.utc();\n      opts.prettify = function(num) {\n        return timeFormatter(timeFormat, new Date(num));\n      };\n\n    } else if (dataType === \"datetime\") {\n      let timezone = $el.data(\"timezone\");\n      if (timezone)\n        timeFormatter = strftime.timezone(timezone);\n      else\n        timeFormatter = strftime;\n\n      opts.prettify = function(num) {\n        return timeFormatter(timeFormat, new Date(num));\n      };\n    } else if (dataType === \"number\") {\n      if (typeof round !== \"undefined\")\n        opts.prettify = function(num) {\n          let factor = Math.pow(10, round);\n          return Math.round(num * factor) / factor;\n        };\n    }\n\n    $el.ionRangeSlider(opts);\n\n    function getValue() {\n      let result = $el.data(\"ionRangeSlider\").result;\n\n      // Function for converting numeric value from slider to appropriate type.\n      let convert;\n      let dataType = $el.data(\"data-type\");\n      if (dataType === \"date\") {\n        convert = function(val) {\n          return formatDateUTC(new Date(+val));\n        };\n      } else if (dataType === \"datetime\") {\n        convert = function(val) {\n          // Convert ms to s\n          return +val / 1000;\n        };\n      } else {\n        convert = function(val) { return +val; };\n      }\n\n      if ($el.data(\"ionRangeSlider\").options.type === \"double\") {\n        return [convert(result.from), convert(result.to)];\n      } else {\n        return convert(result.from);\n      }\n    }\n\n    let lastKnownKeys = null;\n\n    $el.on(\"change.crosstalkSliderInput\", function(event) {\n      if (!$el.data(\"updating\") && !$el.data(\"animating\")) {\n        let [from, to] = getValue();\n        let keys = [];\n        for (let i = 0; i < data.values.length; i++) {\n          let val = data.values[i];\n          if (val >= from && val <= to) {\n            keys.push(data.keys[i]);\n          }\n        }\n        keys.sort();\n        ctHandle.set(keys);\n        lastKnownKeys = keys;\n      }\n    });\n\n\n    // let $el = $(el);\n    // $el.on(\"change\", \"input[type=\"checkbox\"]\", function() {\n    //   let checked = $el.find(\"input[type=\"checkbox\"]:checked\");\n    //   if (checked.length === 0) {\n    //     ctHandle.clear();\n    //   } else {\n    //     let keys = {};\n    //     checked.each(function() {\n    //       data.map[this.value].forEach(function(key) {\n    //         keys[key] = true;\n    //       });\n    //     });\n    //     let keyArray = Object.keys(keys);\n    //     keyArray.sort();\n    //     ctHandle.set(keyArray);\n    //   }\n    // });\n\n    return {\n      suspend: function() {\n        ctHandle.clear();\n      },\n      resume: function() {\n        if (lastKnownKeys)\n          ctHandle.set(lastKnownKeys);\n      }\n    };\n  }\n});\n\n\n// Convert a number to a string with leading zeros\nfunction padZeros(n, digits) {\n  let str = n.toString();\n  while (str.length < digits)\n    str = \"0\" + str;\n  return str;\n}\n\n// Given a Date object, return a string in yyyy-mm-dd format, using the\n// UTC date. This may be a day off from the date in the local time zone.\nfunction formatDateUTC(date) {\n  if (date instanceof Date) {\n    return date.getUTCFullYear() + \"-\" +\n           padZeros(date.getUTCMonth()+1, 2) + \"-\" +\n           padZeros(date.getUTCDate(), 2);\n\n  } else {\n    return null;\n  }\n}\n",
+    "import Events from \"./events\";\nimport grp from \"./group\";\nimport * as util from \"./util\";\n\n/**\n * Use this class to read and write (and listen for changes to) the selection\n * for a Crosstalk group. This is intended to be used for linked brushing.\n *\n * If two (or more) `SelectionHandle` instances in the same webpage share the\n * same group name, they will share the same state. Setting the selection using\n * one `SelectionHandle` instance will result in the `value` property instantly\n * changing across the others, and `\"change\"` event listeners on all instances\n * (including the one that initiated the sending) will fire.\n *\n * @param {string} [group] - The name of the Crosstalk group, or if none,\n *   null or undefined (or any other falsy value). This can be changed later\n *   via the [SelectionHandle#setGroup](#setGroup) method.\n * @param {Object} [extraInfo] - An object whose properties will be copied to\n *   the event object whenever an event is emitted.\n */\nexport class SelectionHandle {\n\n  constructor(group = null, extraInfo = null) {\n    this._eventRelay = new Events();\n    this._emitter = new util.SubscriptionTracker(this._eventRelay);\n\n    // Name of the group we're currently tracking, if any. Can change over time.\n    this._group = null;\n    // The Var we're currently tracking, if any. Can change over time.\n    this._var = null;\n    // The event handler subscription we currently have on var.on(\"change\").\n    this._varOnChangeSub = null;\n\n    this._extraInfo = util.extend({ sender: this }, extraInfo);\n\n    this.setGroup(group);\n  }\n\n  /**\n   * Changes the Crosstalk group membership of this SelectionHandle. The group\n   * being switched away from (if any) will not have its selection value\n   * modified as a result of calling `setGroup`, even if this handle was the\n   * most recent handle to set the selection of the group.\n   *\n   * The group being switched to (if any) will also not have its selection value\n   * modified as a result of calling `setGroup`. If you want to set the\n   * selection value of the new group, call `set` explicitly.\n   *\n   * @param {string} group - The name of the Crosstalk group, or null (or\n   *   undefined) to clear the group.\n   */\n  setGroup(group) {\n    // If group is unchanged, do nothing\n    if (this._group === group)\n      return;\n    // Treat null, undefined, and other falsy values the same\n    if (!this._group && !group)\n      return;\n\n    if (this._var) {\n      this._var.off(\"change\", this._varOnChangeSub);\n      this._var = null;\n      this._varOnChangeSub = null;\n    }\n\n    this._group = group;\n\n    if (group) {\n      this._var = grp(group).var(\"selection\");\n      let sub = this._var.on(\"change\", (e) => {\n        this._eventRelay.trigger(\"change\", e, this);\n      });\n      this._varOnChangeSub = sub;\n    }\n  }\n\n  /**\n   * Retrieves the current selection for the group represented by this\n   * `SelectionHandle`.\n   *\n   * - If no selection is active, then this value will be falsy.\n   * - If a selection is active, but no data points are selected, then this\n   *   value will be an empty array.\n   * - If a selection is active, and data points are selected, then the keys\n   *   of the selected data points will be present in the array.\n   */\n  get value() {\n    return this._var ? this._var.get() : null;\n  }\n\n  /**\n   * Combines the given `extraInfo` (if any) with the handle's default\n   * `_extraInfo` (if any).\n   * @private\n   */\n  _mergeExtraInfo(extraInfo) {\n    // Important incidental effect: shallow clone is returned\n    return util.extend({},\n      this._extraInfo ? this._extraInfo : null,\n      extraInfo ? extraInfo : null);\n  }\n\n  /**\n   * Overwrites the current selection for the group, and raises the `\"change\"`\n   * event among all of the group's '`SelectionHandle` instances (including\n   * this one).\n   *\n   * @fires SelectionHandle#change\n   * @param {string[]} selectedKeys - Falsy, empty array, or array of keys (see\n   *   {@link SelectionHandle#value}).\n   * @param {Object} [extraInfo] - Extra properties to be included on the event\n   *   object that's passed to listeners (in addition to any options that were\n   *   passed into the `SelectionHandle` constructor).\n   */\n  set(selectedKeys, extraInfo) {\n    if (this._var)\n      this._var.set(selectedKeys, this._mergeExtraInfo(extraInfo));\n  }\n\n  /**\n   * Overwrites the current selection for the group, and raises the `\"change\"`\n   * event among all of the group's '`SelectionHandle` instances (including\n   * this one).\n   *\n   * @fires SelectionHandle#change\n   * @param {Object} [extraInfo] - Extra properties to be included on the event\n   *   object that's passed to listeners (in addition to any that were passed\n   *   into the `SelectionHandle` constructor).\n   */\n  clear(extraInfo) {\n    if (this._var)\n      this.set(void 0, this._mergeExtraInfo(extraInfo));\n  }\n\n  /**\n   * Subscribes to events on this `SelectionHandle`.\n   *\n   * @param {string} eventType - Indicates the type of events to listen to.\n   *   Currently, only `\"change\"` is supported.\n   * @param {SelectionHandle~listener} listener - The callback function that\n   *   will be invoked when the event occurs.\n   * @return {string} - A token to pass to {@link SelectionHandle#off} to cancel\n   *   this subscription.\n   */\n  on(eventType, listener) {\n    return this._emitter.on(eventType, listener);\n  }\n\n  /**\n   * Cancels event subscriptions created by {@link SelectionHandle#on}.\n   *\n   * @param {string} eventType - The type of event to unsubscribe.\n   * @param {string|SelectionHandle~listener} listener - Either the callback\n   *   function previously passed into {@link SelectionHandle#on}, or the\n   *   string that was returned from {@link SelectionHandle#on}.\n   */\n  off(eventType, listener) {\n    return this._emitter.off(eventType, listener);\n  }\n\n  /**\n   * Shuts down the `SelectionHandle` object.\n   *\n   * Removes all event listeners that were added through this handle.\n   */\n  close() {\n    this._emitter.removeAllListeners();\n    this.setGroup(null);\n  }\n}\n\n/**\n * @callback SelectionHandle~listener\n * @param {Object} event - An object containing details of the event. For\n *   `\"change\"` events, this includes the properties `value` (the new\n *   value of the selection, or `undefined` if no selection is active),\n *   `oldValue` (the previous value of the selection), and `sender` (the\n *   `SelectionHandle` instance that made the change).\n */\n\n/**\n * @event SelectionHandle#change\n * @type {object}\n * @property {object} value - The new value of the selection, or `undefined`\n *   if no selection is active.\n * @property {object} oldValue - The previous value of the selection.\n * @property {SelectionHandle} sender - The `SelectionHandle` instance that\n *   changed the value.\n */\n",
+    "export function extend(target, ...sources) {\n  for (let i = 0; i < sources.length; i++) {\n    let src = sources[i];\n    if (typeof(src) === \"undefined\" || src === null)\n      continue;\n\n    for (let key in src) {\n      if (src.hasOwnProperty(key)) {\n        target[key] = src[key];\n      }\n    }\n  }\n  return target;\n}\n\nexport function checkSorted(list) {\n  for (let i = 1; i < list.length; i++) {\n    if (list[i] <= list[i-1]) {\n      throw new Error(\"List is not sorted or contains duplicate\");\n    }\n  }\n}\n\nexport function diffSortedLists(a, b) {\n  let i_a = 0;\n  let i_b = 0;\n\n  if (!a) a = [];\n  if (!b) b = [];\n\n  let a_only = [];\n  let b_only = [];\n\n  checkSorted(a);\n  checkSorted(b);\n\n  while (i_a < a.length && i_b < b.length) {\n    if (a[i_a] === b[i_b]) {\n      i_a++;\n      i_b++;\n    } else if (a[i_a] < b[i_b]) {\n      a_only.push(a[i_a++]);\n    } else {\n      b_only.push(b[i_b++]);\n    }\n  }\n\n  if (i_a < a.length)\n    a_only = a_only.concat(a.slice(i_a));\n  if (i_b < b.length)\n    b_only = b_only.concat(b.slice(i_b));\n  return {\n    removed: a_only,\n    added: b_only\n  };\n}\n\n// Convert from wide: { colA: [1,2,3], colB: [4,5,6], ... }\n// to long: [ {colA: 1, colB: 4}, {colA: 2, colB: 5}, ... ]\nexport function dataframeToD3(df) {\n  let names = [];\n  let length;\n  for (let name in df) {\n    if (df.hasOwnProperty(name))\n      names.push(name);\n    if (typeof(df[name]) !== \"object\" || typeof(df[name].length) === \"undefined\") {\n      throw new Error(\"All fields must be arrays\");\n    } else if (typeof(length) !== \"undefined\" && length !== df[name].length) {\n      throw new Error(\"All fields must be arrays of the same length\");\n    }\n    length = df[name].length;\n  }\n  let results = [];\n  let item;\n  for (let row = 0; row < length; row++) {\n    item = {};\n    for (let col = 0; col < names.length; col++) {\n      item[names[col]] = df[names[col]][row];\n    }\n    results.push(item);\n  }\n  return results;\n}\n\n/**\n * Keeps track of all event listener additions/removals and lets all active\n * listeners be removed with a single operation.\n *\n * @private\n */\nexport class SubscriptionTracker {\n  constructor(emitter) {\n    this._emitter = emitter;\n    this._subs = {};\n  }\n\n  on(eventType, listener) {\n    let sub = this._emitter.on(eventType, listener);\n    this._subs[sub] = eventType;\n    return sub;\n  }\n\n  off(eventType, listener) {\n    let sub = this._emitter.off(eventType, listener);\n    if (sub) {\n      delete this._subs[sub];\n    }\n    return sub;\n  }\n\n  removeAllListeners() {\n    let current_subs = this._subs;\n    this._subs = {};\n    Object.keys(current_subs).forEach((sub) => {\n      this._emitter.off(current_subs[sub], sub);\n    });\n  }\n}\n",
+    "import Events from \"./events\";\n\nexport default class Var {\n  constructor(group, name, /*optional*/ value) {\n    this._group = group;\n    this._name = name;\n    this._value = value;\n    this._events = new Events();\n  }\n\n  get() {\n    return this._value;\n  }\n\n  set(value, /*optional*/ event) {\n    if (this._value === value) {\n      // Do nothing; the value hasn't changed\n      return;\n    }\n    let oldValue = this._value;\n    this._value = value;\n    // Alert JavaScript listeners that the value has changed\n    let evt = {};\n    if (event && typeof(event) === \"object\") {\n      for (let k in event) {\n        if (event.hasOwnProperty(k))\n          evt[k] = event[k];\n      }\n    }\n    evt.oldValue = oldValue;\n    evt.value = value;\n    this._events.trigger(\"change\", evt, this);\n\n    // TODO: Make this extensible, to let arbitrary back-ends know that\n    // something has changed\n    if (global.Shiny && global.Shiny.onInputChange) {\n      global.Shiny.onInputChange(\n        \".clientValue-\" +\n          (this._group.name !== null ? this._group.name + \"-\" : \"\") +\n          this._name,\n        typeof(value) === \"undefined\" ? null : value\n      );\n    }\n  }\n\n  on(eventType, listener) {\n    return this._events.on(eventType, listener);\n  }\n\n  off(eventType, listener) {\n    return this._events.off(eventType, listener);\n  }\n}\n"
+  ]
+}
\ No newline at end of file
diff --git a/articles/rxode2-model-types_files/crosstalk-1.2.1/js/crosstalk.min.js b/articles/rxode2-model-types_files/crosstalk-1.2.1/js/crosstalk.min.js
new file mode 100644
index 000000000..b7ec0ac9f
--- /dev/null
+++ b/articles/rxode2-model-types_files/crosstalk-1.2.1/js/crosstalk.min.js
@@ -0,0 +1,2 @@
+!function o(u,a,l){function s(n,e){if(!a[n]){if(!u[n]){var t="function"==typeof require&&require;if(!e&&t)return t(n,!0);if(f)return f(n,!0);var r=new Error("Cannot find module '"+n+"'");throw r.code="MODULE_NOT_FOUND",r}var i=a[n]={exports:{}};u[n][0].call(i.exports,function(e){var t=u[n][1][e];return s(t||e)},i,i.exports,o,u,a,l)}return a[n].exports}for(var f="function"==typeof require&&require,e=0;e?@[\\\]^`{|}~])/g,"\\$1")+"']"),r=JSON.parse(n[0].innerText),i=e.factory(t,r);o(t).data("crosstalk-instance",i),o(t).addClass("crosstalk-input-bound")}if(t.Shiny){var e=new t.Shiny.InputBinding,u=t.jQuery;u.extend(e,{find:function(e){return u(e).find(".crosstalk-input")},initialize:function(e){var t,n;u(e).hasClass("crosstalk-input-bound")||(n=o(t=e),Object.keys(r).forEach(function(e){n.hasClass(e)&&!n.hasClass("crosstalk-input-bound")&&i(r[e],t)}))},getId:function(e){return e.id},getValue:function(e){},setValue:function(e,t){},receiveMessage:function(e,t){},subscribe:function(e,t){u(e).data("crosstalk-instance").resume()},unsubscribe:function(e){u(e).data("crosstalk-instance").suspend()}}),t.Shiny.inputBindings.register(e,"crosstalk.inputBinding")}}).call(this,"undefined"!=typeof global?global:"undefined"!=typeof self?self:"undefined"!=typeof window?window:{})},{}],7:[function(r,e,t){(function(e){"use strict";var t=function(e){{if(e&&e.__esModule)return e;var t={};if(null!=e)for(var n in e)Object.prototype.hasOwnProperty.call(e,n)&&(t[n]=e[n]);return t.default=e,t}}(r("./input")),n=r("./filter");var a=e.jQuery;t.register({className:"crosstalk-input-checkboxgroup",factory:function(e,r){var i=new n.FilterHandle(r.group),o=void 0,u=a(e);return u.on("change","input[type='checkbox']",function(){var e=u.find("input[type='checkbox']:checked");if(0===e.length)o=null,i.clear();else{var t={};e.each(function(){r.map[this.value].forEach(function(e){t[e]=!0})});var n=Object.keys(t);n.sort(),o=n,i.set(n)}}),{suspend:function(){i.clear()},resume:function(){o&&i.set(o)}}}})}).call(this,"undefined"!=typeof global?global:"undefined"!=typeof self?self:"undefined"!=typeof window?window:{})},{"./filter":2,"./input":6}],8:[function(r,e,t){(function(e){"use strict";var t=n(r("./input")),l=n(r("./util")),s=r("./filter");function n(e){if(e&&e.__esModule)return e;var t={};if(null!=e)for(var n in e)Object.prototype.hasOwnProperty.call(e,n)&&(t[n]=e[n]);return t.default=e,t}var f=e.jQuery;t.register({className:"crosstalk-input-select",factory:function(e,n){var t=l.dataframeToD3(n.items),r={options:[{value:"",label:"(All)"}].concat(t),valueField:"value",labelField:"label",searchField:"label"},i=f(e).find("select")[0],o=f(i).selectize(r)[0].selectize,u=new s.FilterHandle(n.group),a=void 0;return o.on("change",function(){if(0===o.items.length)a=null,u.clear();else{var t={};o.items.forEach(function(e){n.map[e].forEach(function(e){t[e]=!0})});var e=Object.keys(t);e.sort(),a=e,u.set(e)}}),{suspend:function(){u.clear()},resume:function(){a&&u.set(a)}}}})}).call(this,"undefined"!=typeof global?global:"undefined"!=typeof self?self:"undefined"!=typeof window?window:{})},{"./filter":2,"./input":6,"./util":11}],9:[function(n,e,t){(function(e){"use strict";var d=function(e,t){if(Array.isArray(e))return e;if(Symbol.iterator in Object(e))return function(e,t){var n=[],r=!0,i=!1,o=void 0;try{for(var u,a=e[Symbol.iterator]();!(r=(u=a.next()).done)&&(n.push(u.value),!t||n.length!==t);r=!0);}catch(e){i=!0,o=e}finally{try{!r&&a.return&&a.return()}finally{if(i)throw o}}return n}(e,t);throw new TypeError("Invalid attempt to destructure non-iterable instance")},t=function(e){{if(e&&e.__esModule)return e;var t={};if(null!=e)for(var n in e)Object.prototype.hasOwnProperty.call(e,n)&&(t[n]=e[n]);return t.default=e,t}}(n("./input")),a=n("./filter");var v=e.jQuery,p=e.strftime;function y(e,t){for(var n=e.toString();n.length {\n        this._eventRelay.trigger(\"change\", e, this);\n      });\n      this._varOnChangeSub = sub;\n    }\n  }\n\n  /**\n   * Combine the given `extraInfo` (if any) with the handle's default\n   * `_extraInfo` (if any).\n   * @private\n   */\n  _mergeExtraInfo(extraInfo) {\n    return util.extend({},\n      this._extraInfo ? this._extraInfo : null,\n      extraInfo ? extraInfo : null);\n  }\n\n  /**\n   * Close the handle. This clears this handle's contribution to the filter set,\n   * and unsubscribes all event listeners.\n   */\n  close() {\n    this._emitter.removeAllListeners();\n    this.clear();\n    this.setGroup(null);\n  }\n\n  /**\n   * Clear this handle's contribution to the filter set.\n   *\n   * @param {Object} [extraInfo] - Extra properties to be included on the event\n   *   object that's passed to listeners (in addition to any options that were\n   *   passed into the `FilterHandle` constructor).\n   * \n   * @fires FilterHandle#change\n   */\n  clear(extraInfo) {\n    if (!this._filterSet)\n      return;\n    this._filterSet.clear(this._id);\n    this._onChange(extraInfo);\n  }\n\n  /**\n   * Set this handle's contribution to the filter set. This array should consist\n   * of the keys of the rows that _should_ be displayed; any keys that are not\n   * present in the array will be considered _filtered out_. Note that multiple\n   * `FilterHandle` instances in the group may each contribute an array of keys,\n   * and only those keys that appear in _all_ of the arrays make it through the\n   * filter.\n   *\n   * @param {string[]} keys - Empty array, or array of keys. To clear the\n   *   filter, don't pass an empty array; instead, use the\n   *   {@link FilterHandle#clear} method.\n   * @param {Object} [extraInfo] - Extra properties to be included on the event\n   *   object that's passed to listeners (in addition to any options that were\n   *   passed into the `FilterHandle` constructor).\n   * \n   * @fires FilterHandle#change\n   */\n  set(keys, extraInfo) {\n    if (!this._filterSet)\n      return;\n    this._filterSet.update(this._id, keys);\n    this._onChange(extraInfo);\n  }\n\n  /**\n   * @return {string[]|null} - Either: 1) an array of keys that made it through\n   *   all of the `FilterHandle` instances, or, 2) `null`, which means no filter\n   *   is being applied (all data should be displayed).\n   */\n  get filteredKeys() {\n    return this._filterSet ? this._filterSet.value : null;\n  }\n\n  /**\n   * Subscribe to events on this `FilterHandle`.\n   *\n   * @param {string} eventType - Indicates the type of events to listen to.\n   *   Currently, only `\"change\"` is supported.\n   * @param {FilterHandle~listener} listener - The callback function that\n   *   will be invoked when the event occurs.\n   * @return {string} - A token to pass to {@link FilterHandle#off} to cancel\n   *   this subscription.\n   */\n  on(eventType, listener) {\n    return this._emitter.on(eventType, listener);\n  }\n\n  /**\n   * Cancel event subscriptions created by {@link FilterHandle#on}.\n   *\n   * @param {string} eventType - The type of event to unsubscribe.\n   * @param {string|FilterHandle~listener} listener - Either the callback\n   *   function previously passed into {@link FilterHandle#on}, or the\n   *   string that was returned from {@link FilterHandle#on}.\n   */\n  off(eventType, listener) {\n    return this._emitter.off(eventType, listener);\n  }\n\n  _onChange(extraInfo) {\n    if (!this._filterSet)\n      return;\n    this._filterVar.set(this._filterSet.value, this._mergeExtraInfo(extraInfo));\n  }\n\n  /**\n   * @callback FilterHandle~listener\n   * @param {Object} event - An object containing details of the event. For\n   *   `\"change\"` events, this includes the properties `value` (the new\n   *   value of the filter set, or `null` if no filter set is active),\n   *   `oldValue` (the previous value of the filter set), and `sender` (the\n   *   `FilterHandle` instance that made the change).\n   */\n\n}\n\n/**\n * @event FilterHandle#change\n * @type {object}\n * @property {object} value - The new value of the filter set, or `null`\n *   if no filter set is active.\n * @property {object} oldValue - The previous value of the filter set.\n * @property {FilterHandle} sender - The `FilterHandle` instance that\n *   changed the value.\n */\n","import { diffSortedLists } from \"./util\";\n\nfunction naturalComparator(a, b) {\n  if (a === b) {\n    return 0;\n  } else if (a < b) {\n    return -1;\n  } else if (a > b) {\n    return 1;\n  }\n}\n\n/**\n * @private\n */\nexport default class FilterSet {\n  constructor() {\n    this.reset();\n  }\n\n  reset() {\n    // Key: handle ID, Value: array of selected keys, or null\n    this._handles = {};\n    // Key: key string, Value: count of handles that include it\n    this._keys = {};\n    this._value = null;\n    this._activeHandles = 0;\n  }\n\n  get value() {\n    return this._value;\n  }\n\n  update(handleId, keys) {\n    if (keys !== null) {\n      keys = keys.slice(0); // clone before sorting\n      keys.sort(naturalComparator);\n    }\n\n    let {added, removed} = diffSortedLists(this._handles[handleId], keys);\n    this._handles[handleId] = keys;\n\n    for (let i = 0; i < added.length; i++) {\n      this._keys[added[i]] = (this._keys[added[i]] || 0) + 1;\n    }\n    for (let i = 0; i < removed.length; i++) {\n      this._keys[removed[i]]--;\n    }\n\n    this._updateValue(keys);\n  }\n\n  /**\n   * @param {string[]} keys Sorted array of strings that indicate\n   * a superset of possible keys.\n   * @private\n   */\n  _updateValue(keys = this._allKeys) {\n    let handleCount = Object.keys(this._handles).length;\n    if (handleCount === 0) {\n      this._value = null;\n    } else {\n      this._value = [];\n      for (let i = 0; i < keys.length; i++) {\n        let count = this._keys[keys[i]];\n        if (count === handleCount) {\n          this._value.push(keys[i]);\n        }\n      }\n    }\n  }\n\n  clear(handleId) {\n    if (typeof(this._handles[handleId]) === \"undefined\") {\n      return;\n    }\n\n    let keys = this._handles[handleId];\n    if (!keys) {\n      keys = [];\n    }\n\n    for (let i = 0; i < keys.length; i++) {\n      this._keys[keys[i]]--;\n    }\n    delete this._handles[handleId];\n\n    this._updateValue();\n  }\n\n  get _allKeys() {\n    let allKeys = Object.keys(this._keys);\n    allKeys.sort(naturalComparator);\n    return allKeys;\n  }\n}\n","import Var from \"./var\";\n\n// Use a global so that multiple copies of crosstalk.js can be loaded and still\n// have groups behave as singletons across all copies.\nglobal.__crosstalk_groups = global.__crosstalk_groups || {};\nlet groups = global.__crosstalk_groups;\n\nexport default function group(groupName) {\n  if (groupName && typeof(groupName) === \"string\") {\n    if (!groups.hasOwnProperty(groupName)) {\n      groups[groupName] = new Group(groupName);\n    }\n    return groups[groupName];\n  } else if (typeof(groupName) === \"object\" && groupName._vars && groupName.var) {\n    // Appears to already be a group object\n    return groupName;\n  } else if (Array.isArray(groupName) &&\n      groupName.length == 1 &&\n      typeof(groupName[0]) === \"string\") {\n    return group(groupName[0]);\n  } else {\n    throw new Error(\"Invalid groupName argument\");\n  }\n}\n\nclass Group {\n  constructor(name) {\n    this.name = name;\n    this._vars = {};\n  }\n\n  var(name) {\n    if (!name || typeof(name) !== \"string\") {\n      throw new Error(\"Invalid var name\");\n    }\n\n    if (!this._vars.hasOwnProperty(name))\n      this._vars[name] = new Var(this, name);\n    return this._vars[name];\n  }\n\n  has(name) {\n    if (!name || typeof(name) !== \"string\") {\n      throw new Error(\"Invalid var name\");\n    }\n\n    return this._vars.hasOwnProperty(name);\n  }\n}\n","import group from \"./group\";\nimport { SelectionHandle } from \"./selection\";\nimport { FilterHandle } from \"./filter\";\nimport { bind } from \"./input\";\nimport \"./input_selectize\";\nimport \"./input_checkboxgroup\";\nimport \"./input_slider\";\n\nconst defaultGroup = group(\"default\");\n\nfunction var_(name) {\n  return defaultGroup.var(name);\n}\n\nfunction has(name) {\n  return defaultGroup.has(name);\n}\n\nif (global.Shiny) {\n  global.Shiny.addCustomMessageHandler(\"update-client-value\", function(message) {\n    if (typeof(message.group) === \"string\") {\n      group(message.group).var(message.name).set(message.value);\n    } else {\n      var_(message.name).set(message.value);\n    }\n  });\n}\n\nconst crosstalk = {\n  group: group,\n  var: var_,\n  has: has,\n  SelectionHandle: SelectionHandle,\n  FilterHandle: FilterHandle,\n  bind: bind\n};\n\n/**\n * @namespace crosstalk\n */\nexport default crosstalk;\nglobal.crosstalk = crosstalk;\n","let $ = global.jQuery;\n\nlet bindings = {};\n\nexport function register(reg) {\n  bindings[reg.className] = reg;\n  if (global.document && global.document.readyState !== \"complete\") {\n    $(() => {\n      bind();\n    });\n  } else if (global.document) {\n    setTimeout(bind, 100);\n  }\n}\n\nexport function bind() {\n  Object.keys(bindings).forEach(function(className) {\n    let binding = bindings[className];\n    $(\".\" + binding.className).not(\".crosstalk-input-bound\").each(function(i, el) {\n      bindInstance(binding, el);\n    });\n  });\n}\n\n// Escape jQuery identifier\nfunction $escape(val) {\n  return val.replace(/([!\"#$%&'()*+,./:;<=>?@[\\\\\\]^`{|}~])/g, \"\\\\$1\");\n}\n\nfunction bindEl(el) {\n  let $el = $(el);\n  Object.keys(bindings).forEach(function(className) {\n    if ($el.hasClass(className) && !$el.hasClass(\"crosstalk-input-bound\")) {\n      let binding = bindings[className];\n      bindInstance(binding, el);\n    }\n  });\n}\n\nfunction bindInstance(binding, el) {\n  let jsonEl = $(el).find(\"script[type='application/json'][data-for='\" + $escape(el.id) + \"']\");\n  let data = JSON.parse(jsonEl[0].innerText);\n\n  let instance = binding.factory(el, data);\n  $(el).data(\"crosstalk-instance\", instance);\n  $(el).addClass(\"crosstalk-input-bound\");\n}\n\nif (global.Shiny) {\n  let inputBinding = new global.Shiny.InputBinding();\n  let $ = global.jQuery;\n  $.extend(inputBinding, {\n    find: function(scope) {\n      return $(scope).find(\".crosstalk-input\");\n    },\n    initialize: function(el) {\n      if (!$(el).hasClass(\"crosstalk-input-bound\")) {\n        bindEl(el);\n      }\n    },\n    getId: function(el) {\n      return el.id;\n    },\n    getValue: function(el) {\n\n    },\n    setValue: function(el, value) {\n\n    },\n    receiveMessage: function(el, data) {\n\n    },\n    subscribe: function(el, callback) {\n      $(el).data(\"crosstalk-instance\").resume();\n    },\n    unsubscribe: function(el) {\n      $(el).data(\"crosstalk-instance\").suspend();\n    }\n  });\n  global.Shiny.inputBindings.register(inputBinding, \"crosstalk.inputBinding\");\n}\n","import * as input from \"./input\";\nimport { FilterHandle } from \"./filter\";\n\nlet $ = global.jQuery;\n\ninput.register({\n  className: \"crosstalk-input-checkboxgroup\",\n\n  factory: function(el, data) {\n    /*\n     * map: {\"groupA\": [\"keyA\", \"keyB\", ...], ...}\n     * group: \"ct-groupname\"\n     */\n    let ctHandle = new FilterHandle(data.group);\n\n    let lastKnownKeys;\n    let $el = $(el);\n    $el.on(\"change\", \"input[type='checkbox']\", function() {\n      let checked = $el.find(\"input[type='checkbox']:checked\");\n      if (checked.length === 0) {\n        lastKnownKeys = null;\n        ctHandle.clear();\n      } else {\n        let keys = {};\n        checked.each(function() {\n          data.map[this.value].forEach(function(key) {\n            keys[key] = true;\n          });\n        });\n        let keyArray = Object.keys(keys);\n        keyArray.sort();\n        lastKnownKeys = keyArray;\n        ctHandle.set(keyArray);\n      }\n    });\n\n    return {\n      suspend: function() {\n        ctHandle.clear();\n      },\n      resume: function() {\n        if (lastKnownKeys)\n          ctHandle.set(lastKnownKeys);\n      }\n    };\n  }\n});\n","import * as input from \"./input\";\nimport * as util from \"./util\";\nimport { FilterHandle } from \"./filter\";\n\nlet $ = global.jQuery;\n\ninput.register({\n  className: \"crosstalk-input-select\",\n\n  factory: function(el, data) {\n    /*\n     * items: {value: [...], label: [...]}\n     * map: {\"groupA\": [\"keyA\", \"keyB\", ...], ...}\n     * group: \"ct-groupname\"\n     */\n\n    let first = [{value: \"\", label: \"(All)\"}];\n    let items = util.dataframeToD3(data.items);\n    let opts = {\n      options: first.concat(items),\n      valueField: \"value\",\n      labelField: \"label\",\n      searchField: \"label\"\n    };\n\n    let select = $(el).find(\"select\")[0];\n\n    let selectize = $(select).selectize(opts)[0].selectize;\n\n    let ctHandle = new FilterHandle(data.group);\n\n    let lastKnownKeys;\n    selectize.on(\"change\", function() {\n      if (selectize.items.length === 0) {\n        lastKnownKeys = null;\n        ctHandle.clear();\n      } else {\n        let keys = {};\n        selectize.items.forEach(function(group) {\n          data.map[group].forEach(function(key) {\n            keys[key] = true;\n          });\n        });\n        let keyArray = Object.keys(keys);\n        keyArray.sort();\n        lastKnownKeys = keyArray;\n        ctHandle.set(keyArray);\n      }\n    });\n\n    return {\n      suspend: function() {\n        ctHandle.clear();\n      },\n      resume: function() {\n        if (lastKnownKeys)\n          ctHandle.set(lastKnownKeys);\n      }\n    };\n  }\n});\n","import * as input from \"./input\";\nimport { FilterHandle } from \"./filter\";\n\nlet $ = global.jQuery;\nlet strftime = global.strftime;\n\ninput.register({\n  className: \"crosstalk-input-slider\",\n\n  factory: function(el, data) {\n    /*\n     * map: {\"groupA\": [\"keyA\", \"keyB\", ...], ...}\n     * group: \"ct-groupname\"\n     */\n    let ctHandle = new FilterHandle(data.group);\n\n    let opts = {};\n    let $el = $(el).find(\"input\");\n    let dataType = $el.data(\"data-type\");\n    let timeFormat = $el.data(\"time-format\");\n    let round = $el.data(\"round\");\n    let timeFormatter;\n\n    // Set up formatting functions\n    if (dataType === \"date\") {\n      timeFormatter = strftime.utc();\n      opts.prettify = function(num) {\n        return timeFormatter(timeFormat, new Date(num));\n      };\n\n    } else if (dataType === \"datetime\") {\n      let timezone = $el.data(\"timezone\");\n      if (timezone)\n        timeFormatter = strftime.timezone(timezone);\n      else\n        timeFormatter = strftime;\n\n      opts.prettify = function(num) {\n        return timeFormatter(timeFormat, new Date(num));\n      };\n    } else if (dataType === \"number\") {\n      if (typeof round !== \"undefined\")\n        opts.prettify = function(num) {\n          let factor = Math.pow(10, round);\n          return Math.round(num * factor) / factor;\n        };\n    }\n\n    $el.ionRangeSlider(opts);\n\n    function getValue() {\n      let result = $el.data(\"ionRangeSlider\").result;\n\n      // Function for converting numeric value from slider to appropriate type.\n      let convert;\n      let dataType = $el.data(\"data-type\");\n      if (dataType === \"date\") {\n        convert = function(val) {\n          return formatDateUTC(new Date(+val));\n        };\n      } else if (dataType === \"datetime\") {\n        convert = function(val) {\n          // Convert ms to s\n          return +val / 1000;\n        };\n      } else {\n        convert = function(val) { return +val; };\n      }\n\n      if ($el.data(\"ionRangeSlider\").options.type === \"double\") {\n        return [convert(result.from), convert(result.to)];\n      } else {\n        return convert(result.from);\n      }\n    }\n\n    let lastKnownKeys = null;\n\n    $el.on(\"change.crosstalkSliderInput\", function(event) {\n      if (!$el.data(\"updating\") && !$el.data(\"animating\")) {\n        let [from, to] = getValue();\n        let keys = [];\n        for (let i = 0; i < data.values.length; i++) {\n          let val = data.values[i];\n          if (val >= from && val <= to) {\n            keys.push(data.keys[i]);\n          }\n        }\n        keys.sort();\n        ctHandle.set(keys);\n        lastKnownKeys = keys;\n      }\n    });\n\n\n    // let $el = $(el);\n    // $el.on(\"change\", \"input[type=\"checkbox\"]\", function() {\n    //   let checked = $el.find(\"input[type=\"checkbox\"]:checked\");\n    //   if (checked.length === 0) {\n    //     ctHandle.clear();\n    //   } else {\n    //     let keys = {};\n    //     checked.each(function() {\n    //       data.map[this.value].forEach(function(key) {\n    //         keys[key] = true;\n    //       });\n    //     });\n    //     let keyArray = Object.keys(keys);\n    //     keyArray.sort();\n    //     ctHandle.set(keyArray);\n    //   }\n    // });\n\n    return {\n      suspend: function() {\n        ctHandle.clear();\n      },\n      resume: function() {\n        if (lastKnownKeys)\n          ctHandle.set(lastKnownKeys);\n      }\n    };\n  }\n});\n\n\n// Convert a number to a string with leading zeros\nfunction padZeros(n, digits) {\n  let str = n.toString();\n  while (str.length < digits)\n    str = \"0\" + str;\n  return str;\n}\n\n// Given a Date object, return a string in yyyy-mm-dd format, using the\n// UTC date. This may be a day off from the date in the local time zone.\nfunction formatDateUTC(date) {\n  if (date instanceof Date) {\n    return date.getUTCFullYear() + \"-\" +\n           padZeros(date.getUTCMonth()+1, 2) + \"-\" +\n           padZeros(date.getUTCDate(), 2);\n\n  } else {\n    return null;\n  }\n}\n","import Events from \"./events\";\nimport grp from \"./group\";\nimport * as util from \"./util\";\n\n/**\n * Use this class to read and write (and listen for changes to) the selection\n * for a Crosstalk group. This is intended to be used for linked brushing.\n *\n * If two (or more) `SelectionHandle` instances in the same webpage share the\n * same group name, they will share the same state. Setting the selection using\n * one `SelectionHandle` instance will result in the `value` property instantly\n * changing across the others, and `\"change\"` event listeners on all instances\n * (including the one that initiated the sending) will fire.\n *\n * @param {string} [group] - The name of the Crosstalk group, or if none,\n *   null or undefined (or any other falsy value). This can be changed later\n *   via the [SelectionHandle#setGroup](#setGroup) method.\n * @param {Object} [extraInfo] - An object whose properties will be copied to\n *   the event object whenever an event is emitted.\n */\nexport class SelectionHandle {\n\n  constructor(group = null, extraInfo = null) {\n    this._eventRelay = new Events();\n    this._emitter = new util.SubscriptionTracker(this._eventRelay);\n\n    // Name of the group we're currently tracking, if any. Can change over time.\n    this._group = null;\n    // The Var we're currently tracking, if any. Can change over time.\n    this._var = null;\n    // The event handler subscription we currently have on var.on(\"change\").\n    this._varOnChangeSub = null;\n\n    this._extraInfo = util.extend({ sender: this }, extraInfo);\n\n    this.setGroup(group);\n  }\n\n  /**\n   * Changes the Crosstalk group membership of this SelectionHandle. The group\n   * being switched away from (if any) will not have its selection value\n   * modified as a result of calling `setGroup`, even if this handle was the\n   * most recent handle to set the selection of the group.\n   *\n   * The group being switched to (if any) will also not have its selection value\n   * modified as a result of calling `setGroup`. If you want to set the\n   * selection value of the new group, call `set` explicitly.\n   *\n   * @param {string} group - The name of the Crosstalk group, or null (or\n   *   undefined) to clear the group.\n   */\n  setGroup(group) {\n    // If group is unchanged, do nothing\n    if (this._group === group)\n      return;\n    // Treat null, undefined, and other falsy values the same\n    if (!this._group && !group)\n      return;\n\n    if (this._var) {\n      this._var.off(\"change\", this._varOnChangeSub);\n      this._var = null;\n      this._varOnChangeSub = null;\n    }\n\n    this._group = group;\n\n    if (group) {\n      this._var = grp(group).var(\"selection\");\n      let sub = this._var.on(\"change\", (e) => {\n        this._eventRelay.trigger(\"change\", e, this);\n      });\n      this._varOnChangeSub = sub;\n    }\n  }\n\n  /**\n   * Retrieves the current selection for the group represented by this\n   * `SelectionHandle`.\n   *\n   * - If no selection is active, then this value will be falsy.\n   * - If a selection is active, but no data points are selected, then this\n   *   value will be an empty array.\n   * - If a selection is active, and data points are selected, then the keys\n   *   of the selected data points will be present in the array.\n   */\n  get value() {\n    return this._var ? this._var.get() : null;\n  }\n\n  /**\n   * Combines the given `extraInfo` (if any) with the handle's default\n   * `_extraInfo` (if any).\n   * @private\n   */\n  _mergeExtraInfo(extraInfo) {\n    // Important incidental effect: shallow clone is returned\n    return util.extend({},\n      this._extraInfo ? this._extraInfo : null,\n      extraInfo ? extraInfo : null);\n  }\n\n  /**\n   * Overwrites the current selection for the group, and raises the `\"change\"`\n   * event among all of the group's '`SelectionHandle` instances (including\n   * this one).\n   *\n   * @fires SelectionHandle#change\n   * @param {string[]} selectedKeys - Falsy, empty array, or array of keys (see\n   *   {@link SelectionHandle#value}).\n   * @param {Object} [extraInfo] - Extra properties to be included on the event\n   *   object that's passed to listeners (in addition to any options that were\n   *   passed into the `SelectionHandle` constructor).\n   */\n  set(selectedKeys, extraInfo) {\n    if (this._var)\n      this._var.set(selectedKeys, this._mergeExtraInfo(extraInfo));\n  }\n\n  /**\n   * Overwrites the current selection for the group, and raises the `\"change\"`\n   * event among all of the group's '`SelectionHandle` instances (including\n   * this one).\n   *\n   * @fires SelectionHandle#change\n   * @param {Object} [extraInfo] - Extra properties to be included on the event\n   *   object that's passed to listeners (in addition to any that were passed\n   *   into the `SelectionHandle` constructor).\n   */\n  clear(extraInfo) {\n    if (this._var)\n      this.set(void 0, this._mergeExtraInfo(extraInfo));\n  }\n\n  /**\n   * Subscribes to events on this `SelectionHandle`.\n   *\n   * @param {string} eventType - Indicates the type of events to listen to.\n   *   Currently, only `\"change\"` is supported.\n   * @param {SelectionHandle~listener} listener - The callback function that\n   *   will be invoked when the event occurs.\n   * @return {string} - A token to pass to {@link SelectionHandle#off} to cancel\n   *   this subscription.\n   */\n  on(eventType, listener) {\n    return this._emitter.on(eventType, listener);\n  }\n\n  /**\n   * Cancels event subscriptions created by {@link SelectionHandle#on}.\n   *\n   * @param {string} eventType - The type of event to unsubscribe.\n   * @param {string|SelectionHandle~listener} listener - Either the callback\n   *   function previously passed into {@link SelectionHandle#on}, or the\n   *   string that was returned from {@link SelectionHandle#on}.\n   */\n  off(eventType, listener) {\n    return this._emitter.off(eventType, listener);\n  }\n\n  /**\n   * Shuts down the `SelectionHandle` object.\n   *\n   * Removes all event listeners that were added through this handle.\n   */\n  close() {\n    this._emitter.removeAllListeners();\n    this.setGroup(null);\n  }\n}\n\n/**\n * @callback SelectionHandle~listener\n * @param {Object} event - An object containing details of the event. For\n *   `\"change\"` events, this includes the properties `value` (the new\n *   value of the selection, or `undefined` if no selection is active),\n *   `oldValue` (the previous value of the selection), and `sender` (the\n *   `SelectionHandle` instance that made the change).\n */\n\n/**\n * @event SelectionHandle#change\n * @type {object}\n * @property {object} value - The new value of the selection, or `undefined`\n *   if no selection is active.\n * @property {object} oldValue - The previous value of the selection.\n * @property {SelectionHandle} sender - The `SelectionHandle` instance that\n *   changed the value.\n */\n","export function extend(target, ...sources) {\n  for (let i = 0; i < sources.length; i++) {\n    let src = sources[i];\n    if (typeof(src) === \"undefined\" || src === null)\n      continue;\n\n    for (let key in src) {\n      if (src.hasOwnProperty(key)) {\n        target[key] = src[key];\n      }\n    }\n  }\n  return target;\n}\n\nexport function checkSorted(list) {\n  for (let i = 1; i < list.length; i++) {\n    if (list[i] <= list[i-1]) {\n      throw new Error(\"List is not sorted or contains duplicate\");\n    }\n  }\n}\n\nexport function diffSortedLists(a, b) {\n  let i_a = 0;\n  let i_b = 0;\n\n  if (!a) a = [];\n  if (!b) b = [];\n\n  let a_only = [];\n  let b_only = [];\n\n  checkSorted(a);\n  checkSorted(b);\n\n  while (i_a < a.length && i_b < b.length) {\n    if (a[i_a] === b[i_b]) {\n      i_a++;\n      i_b++;\n    } else if (a[i_a] < b[i_b]) {\n      a_only.push(a[i_a++]);\n    } else {\n      b_only.push(b[i_b++]);\n    }\n  }\n\n  if (i_a < a.length)\n    a_only = a_only.concat(a.slice(i_a));\n  if (i_b < b.length)\n    b_only = b_only.concat(b.slice(i_b));\n  return {\n    removed: a_only,\n    added: b_only\n  };\n}\n\n// Convert from wide: { colA: [1,2,3], colB: [4,5,6], ... }\n// to long: [ {colA: 1, colB: 4}, {colA: 2, colB: 5}, ... ]\nexport function dataframeToD3(df) {\n  let names = [];\n  let length;\n  for (let name in df) {\n    if (df.hasOwnProperty(name))\n      names.push(name);\n    if (typeof(df[name]) !== \"object\" || typeof(df[name].length) === \"undefined\") {\n      throw new Error(\"All fields must be arrays\");\n    } else if (typeof(length) !== \"undefined\" && length !== df[name].length) {\n      throw new Error(\"All fields must be arrays of the same length\");\n    }\n    length = df[name].length;\n  }\n  let results = [];\n  let item;\n  for (let row = 0; row < length; row++) {\n    item = {};\n    for (let col = 0; col < names.length; col++) {\n      item[names[col]] = df[names[col]][row];\n    }\n    results.push(item);\n  }\n  return results;\n}\n\n/**\n * Keeps track of all event listener additions/removals and lets all active\n * listeners be removed with a single operation.\n *\n * @private\n */\nexport class SubscriptionTracker {\n  constructor(emitter) {\n    this._emitter = emitter;\n    this._subs = {};\n  }\n\n  on(eventType, listener) {\n    let sub = this._emitter.on(eventType, listener);\n    this._subs[sub] = eventType;\n    return sub;\n  }\n\n  off(eventType, listener) {\n    let sub = this._emitter.off(eventType, listener);\n    if (sub) {\n      delete this._subs[sub];\n    }\n    return sub;\n  }\n\n  removeAllListeners() {\n    let current_subs = this._subs;\n    this._subs = {};\n    Object.keys(current_subs).forEach((sub) => {\n      this._emitter.off(current_subs[sub], sub);\n    });\n  }\n}\n","import Events from \"./events\";\n\nexport default class Var {\n  constructor(group, name, /*optional*/ value) {\n    this._group = group;\n    this._name = name;\n    this._value = value;\n    this._events = new Events();\n  }\n\n  get() {\n    return this._value;\n  }\n\n  set(value, /*optional*/ event) {\n    if (this._value === value) {\n      // Do nothing; the value hasn't changed\n      return;\n    }\n    let oldValue = this._value;\n    this._value = value;\n    // Alert JavaScript listeners that the value has changed\n    let evt = {};\n    if (event && typeof(event) === \"object\") {\n      for (let k in event) {\n        if (event.hasOwnProperty(k))\n          evt[k] = event[k];\n      }\n    }\n    evt.oldValue = oldValue;\n    evt.value = value;\n    this._events.trigger(\"change\", evt, this);\n\n    // TODO: Make this extensible, to let arbitrary back-ends know that\n    // something has changed\n    if (global.Shiny && global.Shiny.onInputChange) {\n      global.Shiny.onInputChange(\n        \".clientValue-\" +\n          (this._group.name !== null ? this._group.name + \"-\" : \"\") +\n          this._name,\n        typeof(value) === \"undefined\" ? null : value\n      );\n    }\n  }\n\n  on(eventType, listener) {\n    return this._events.on(eventType, listener);\n  }\n\n  off(eventType, listener) {\n    return this._events.off(eventType, listener);\n  }\n}\n"]}
\ No newline at end of file
diff --git a/articles/rxode2-model-types_files/crosstalk-1.2.1/scss/crosstalk.scss b/articles/rxode2-model-types_files/crosstalk-1.2.1/scss/crosstalk.scss
new file mode 100644
index 000000000..35665616f
--- /dev/null
+++ b/articles/rxode2-model-types_files/crosstalk-1.2.1/scss/crosstalk.scss
@@ -0,0 +1,75 @@
+/* Adjust margins outwards, so column contents line up with the edges of the
+   parent of container-fluid. */
+.container-fluid.crosstalk-bscols {
+  margin-left: -30px;
+  margin-right: -30px;
+  white-space: normal;
+}
+
+/* But don't adjust the margins outwards if we're directly under the body,
+   i.e. we were the top-level of something at the console. */
+body > .container-fluid.crosstalk-bscols {
+  margin-left: auto;
+  margin-right: auto;
+}
+
+.crosstalk-input-checkboxgroup .crosstalk-options-group .crosstalk-options-column {
+  display: inline-block;
+  padding-right: 12px;
+  vertical-align: top;
+}
+
+@media only screen and (max-width:480px) {
+  .crosstalk-input-checkboxgroup .crosstalk-options-group .crosstalk-options-column {
+    display: block;
+    padding-right: inherit;
+  }
+}
+
+/* Relevant BS3 styles to make filter_checkbox() look reasonable without Bootstrap */
+.crosstalk-input {
+  margin-bottom: 15px; /* a la .form-group */
+  .control-label {
+    margin-bottom: 0;
+    vertical-align: middle;
+  }
+  input[type="checkbox"] {
+    margin: 4px 0 0;
+    margin-top: 1px;
+    line-height: normal;
+  }
+  .checkbox {
+    position: relative;
+    display: block;
+    margin-top: 10px;
+    margin-bottom: 10px;
+  }
+  .checkbox > label{
+    padding-left: 20px;
+    margin-bottom: 0;
+    font-weight: 400;
+    cursor: pointer;
+  }
+  .checkbox input[type="checkbox"],
+  .checkbox-inline input[type="checkbox"] {
+    position: absolute;
+    margin-top: 2px;
+    margin-left: -20px;
+  }
+  .checkbox + .checkbox {
+    margin-top: -5px;
+  }
+  .checkbox-inline {
+    position: relative;
+    display: inline-block;
+    padding-left: 20px;
+    margin-bottom: 0;
+    font-weight: 400;
+    vertical-align: middle;
+    cursor: pointer;
+  }
+  .checkbox-inline + .checkbox-inline {
+    margin-top: 0;
+    margin-left: 10px;
+  }
+}
diff --git a/articles/rxode2-nesting.html b/articles/rxode2-nesting.html
index 6c677d836..2533aa763 100644
--- a/articles/rxode2-nesting.html
+++ b/articles/rxode2-nesting.html
@@ -157,7 +157,7 @@ 
Advanced Features, Model Types, Techni
   

       
Nesting levels in rxode2

             
-            
2023-11-28

+            
2023-11-30

       
       Source: vignettes/rxode2-nesting.Rmd
       
rxode2-nesting.Rmd

@@ -312,24 +312,24 @@ 
Uncertainty in Model parametersdimnames(tMat) <- list(names(theta), names(theta))
 
 tMat

-
#>              TKA         TCl          V2           Q          V3         Kin
-#> TKA   0.10062025 -0.12295469 -0.04531495 -0.02397077 -0.02434600 -0.04904029
-#> TCl  -0.12295469  0.25162132 -0.01212188  0.02716814  0.06137190  0.05300572
-#> V2   -0.04531495 -0.01212188  0.23379983 -0.02496544 -0.04012738  0.07997442
-#> Q    -0.02397077  0.02716814 -0.02496544  0.02821405  0.02076256 -0.04388260
-#> V3   -0.02434600  0.06137190 -0.04012738  0.02076256  0.16198186 -0.11895883
-#> Kin  -0.04904029  0.05300572  0.07997442 -0.04388260 -0.11895883  0.26339638
-#> Kout -0.03343029 -0.02601856  0.08114984  0.02523323 -0.01569376 -0.03609746
-#> EC50 -0.12588070  0.14843107 -0.03577880  0.05992831  0.07451059 -0.02226063
-#>             Kout        EC50
-#> TKA  -0.03343029 -0.12588070
-#> TCl  -0.02601856  0.14843107
-#> V2    0.08114984 -0.03577880
-#> Q     0.02523323  0.05992831
-#> V3   -0.01569376  0.07451059
-#> Kin  -0.03609746 -0.02226063
-#> Kout  0.09716982  0.03006571
-#> EC50  0.03006571  0.31726414
+
#>              TKA          TCl          V2            Q           V3
+#> TKA   0.11619015  0.073703715  0.04369253 -0.016660366 -0.011193396
+#> TCl   0.07370372  0.113971693  0.06841157 -0.015578152 -0.055073884
+#> V2    0.04369253  0.068411574  0.22142001 -0.074616276 -0.019774853
+#> Q    -0.01666037 -0.015578152 -0.07461628  0.075884128  0.020726895
+#> V3   -0.01119340 -0.055073884 -0.01977485  0.020726895  0.075776432
+#> Kin   0.01846965 -0.033098860  0.04143756 -0.008003217  0.020555705
+#> Kout -0.02395367 -0.010482608 -0.02421182 -0.010248683 -0.007926701
+#> EC50 -0.01338289 -0.006578812 -0.05736582  0.089005982  0.030902333
+#>               Kin         Kout         EC50
+#> TKA   0.018469652 -0.023953675 -0.013382894
+#> TCl  -0.033098860 -0.010482608 -0.006578812
+#> V2    0.041437564 -0.024211825 -0.057365823
+#> Q    -0.008003217 -0.010248683  0.089005982
+#> V3    0.020555705 -0.007926701  0.030902333
+#> Kin   0.083079307 -0.012669148 -0.015209539
+#> Kout -0.012669148  0.109646723 -0.028508758
+#> EC50 -0.015209539 -0.028508758  0.117687226

Nesting Variability @@ -397,8 +397,6 @@

Solving the problem=400)

#> using C compiler: ‘gcc (Ubuntu 11.4.0-1ubuntu1~22.04) 11.4.0’
#> unhandled error message: EE:[lsoda] 70000 steps taken before reaching tout
-#>  @(lsoda.c:750
-#> unhandled error message: EE:[lsoda] 70000 steps taken before reaching tout
 #>  @(lsoda.c:750
#> Warning: some ID(s) could not solve the ODEs correctly; These values are
 #> replaced with 'NA'
@@ -409,16 +407,16 @@

Solving the problem#> # A tibble: 8,000 x 24 #> sim.id id `inv.Cl(inv==1)` `inv.Cl(inv==2)` `inv.Ka(inv==1)` #> <int> <fct> <dbl> <dbl> <dbl> -#> 1 1 1 -0.0390 -0.0402 -0.0942 -#> 2 1 2 -0.0390 -0.0402 -0.0942 -#> 3 1 3 -0.0390 -0.0402 -0.0942 -#> 4 1 4 -0.0390 -0.0402 -0.0942 -#> 5 1 5 -0.0390 -0.0402 -0.0942 -#> 6 1 6 -0.0390 -0.0402 -0.0942 -#> 7 1 7 -0.0390 -0.0402 -0.0942 -#> 8 1 8 -0.0390 -0.0402 -0.0942 -#> 9 1 9 -0.0390 -0.0402 -0.0942 -#> 10 1 10 -0.0390 -0.0402 -0.0942 +#> 1 1 1 0.108 0.363 -0.110 +#> 2 1 2 0.108 0.363 -0.110 +#> 3 1 3 0.108 0.363 -0.110 +#> 4 1 4 0.108 0.363 -0.110 +#> 5 1 5 0.108 0.363 -0.110 +#> 6 1 6 0.108 0.363 -0.110 +#> 7 1 7 0.108 0.363 -0.110 +#> 8 1 8 0.108 0.363 -0.110 +#> 9 1 9 0.108 0.363 -0.110 +#> 10 1 10 0.108 0.363 -0.110 #> # i 7,990 more rows #> # i 19 more variables: `inv.Ka(inv==2)` <dbl>, `eye.Cl(eye==1)` <dbl>, #> # `eye.Cl(eye==2)` <dbl>, `eye.Ka(eye==1)` <dbl>, `eye.Ka(eye==2)` <dbl>, @@ -435,17 +433,17 @@

Solving the problem#> #> -- First part of data (object): -- #> # A tibble: 976,000 x 21 -#> sim.id id time inv.Cl inv.Ka eye.Cl eye.Ka iov.Cl iov.Ka C2 C3 -#> <int> <int> [h] <dbl> <dbl> <dbl> <dbl> <dbl> <dbl> <dbl> <dbl> -#> 1 1 1 0 -0.0390 -0.0942 0.291 0.0726 0.0168 0.0267 0 0 -#> 2 1 1 0.1 -0.0390 -0.0942 -0.0154 0.345 0.0168 0.0267 1.24 0.00724 -#> 3 1 1 4 -0.0390 -0.0942 0.291 0.0726 0.0168 0.0267 16.5 5.02 -#> 4 1 1 4.1 -0.0390 -0.0942 -0.0154 0.345 0.0168 0.0267 32.3 5.15 -#> 5 1 1 8 -0.0390 -0.0942 0.291 0.0726 0.0168 0.0267 21.8 8.35 -#> 6 1 1 8.1 -0.0390 -0.0942 -0.0154 0.345 0.0168 0.0267 12.6 8.40 +#> sim.id id time inv.Cl inv.Ka eye.Cl eye.Ka iov.Cl iov.Ka C2 +#> <int> <int> [h] <dbl> <dbl> <dbl> <dbl> <dbl> <dbl> <dbl> +#> 1 1 1 0 0.108 -0.110 0.432 0.586 -0.0881 0.0304 0 +#> 2 1 1 0.1 0.108 -0.110 -0.0583 0.175 -0.0881 0.0304 -18.9 +#> 3 1 1 4 0.108 -0.110 0.432 0.586 -0.0881 0.0304 -847. +#> 4 1 1 4.1 0.108 -0.110 -0.0583 0.175 -0.0881 0.0304 -715. +#> 5 1 1 8 0.108 -0.110 0.432 0.586 -0.0881 0.0304 -3785. +#> 6 1 1 8.1 0.108 -0.110 -0.0583 0.175 -0.0881 0.0304 -4970. #> # i 975,994 more rows -#> # i 10 more variables: CL <dbl>, KA <dbl>, ef0 <dbl>, depot <dbl>, centr <dbl>, -#> # peri <dbl>, eff <dbl>, occ <fct>, eye <fct>, inv <fct> +#> # i 11 more variables: C3 <dbl>, CL <dbl>, KA <dbl>, ef0 <dbl>, depot <dbl>, +#> # centr <dbl>, peri <dbl>, eff <dbl>, occ <fct>, eye <fct>, inv <fct>

There are multiple investigators in a study; Each investigator has a number of individuals enrolled at their site. rxode2 automatically determines the number of investigators and then will @@ -464,63 +462,63 @@

Solving the problem
 print(head(s$params))
#>   sim.id id inv.Cl(inv==1) inv.Cl(inv==2) inv.Ka(inv==1) inv.Ka(inv==2)
-#> 1      1  1    -0.03903519     -0.0402308    -0.09422733     -0.2222389
-#> 2      1  2    -0.03903519     -0.0402308    -0.09422733     -0.2222389
-#> 3      1  3    -0.03903519     -0.0402308    -0.09422733     -0.2222389
-#> 4      1  4    -0.03903519     -0.0402308    -0.09422733     -0.2222389
-#> 5      1  5    -0.03903519     -0.0402308    -0.09422733     -0.2222389
-#> 6      1  6    -0.03903519     -0.0402308    -0.09422733     -0.2222389
+#> 1      1  1      0.1082821      0.3626882      -0.109708     0.09798624
+#> 2      1  2      0.1082821      0.3626882      -0.109708     0.09798624
+#> 3      1  3      0.1082821      0.3626882      -0.109708     0.09798624
+#> 4      1  4      0.1082821      0.3626882      -0.109708     0.09798624
+#> 5      1  5      0.1082821      0.3626882      -0.109708     0.09798624
+#> 6      1  6      0.1082821      0.3626882      -0.109708     0.09798624
 #>   eye.Cl(eye==1) eye.Cl(eye==2) eye.Ka(eye==1) eye.Ka(eye==2) iov.Cl(occ==1)
-#> 1     0.29091811    -0.01542317     0.07258091     0.34505211     0.01684535
-#> 2    -0.14901624    -0.38252332     0.03616125    -0.02581829    -0.01951429
-#> 3     0.04366161     0.04893422     0.34442986     0.05949640     0.02975505
-#> 4     0.53381517    -0.23612630     0.02020768     0.13279331    -0.14357799
-#> 5     0.10876531    -0.01837668    -0.07839463     0.66759002    -0.11951379
-#> 6     0.29345370    -0.16347273     0.16696714    -0.21050912     0.13931739
-#>   iov.Cl(occ==2) iov.Ka(occ==1) iov.Ka(occ==2)       V2       V3      TCl
-#> 1   0.0676210373     0.02665256    -0.05464559 40.19573 297.5459 19.14549
-#> 2  -0.0001926847     0.08155886    -0.10087830 40.19573 297.5459 19.14549
-#> 3   0.0807252964     0.06784367     0.20606147 40.19573 297.5459 19.14549
-#> 4   0.1841479804     0.02825059    -0.03639285 40.19573 297.5459 19.14549
-#> 5   0.0481570368    -0.16042582    -0.03872286 40.19573 297.5459 19.14549
-#> 6  -0.0201587971    -0.03760217    -0.11540276 40.19573 297.5459 19.14549
-#>        eta.Cl       TKA      eta.Ka        Q       Kin     Kout     EC50
-#> 1 -0.01012319 0.1951491 -0.12653552 10.49742 0.7229821 0.749676 200.0693
-#> 2 -0.61749725 0.1951491  0.13550157 10.49742 0.7229821 0.749676 200.0693
-#> 3  0.28943517 0.1951491  0.08638813 10.49742 0.7229821 0.749676 200.0693
-#> 4 -0.32822614 0.1951491 -0.39633056 10.49742 0.7229821 0.749676 200.0693
-#> 5 -0.06070510 0.1951491 -0.47385633 10.49742 0.7229821 0.749676 200.0693
-#> 6  0.32947559 0.1951491 -0.12152307 10.49742 0.7229821 0.749676 200.0693
+#> 1 0.43197371 -0.058328678 0.586264966 0.174884342 -0.08811714 +#> 2 0.08559430 0.006108123 -0.005624186 -0.020710794 0.10637721 +#> 3 0.02708297 -0.001796112 0.240805194 0.009550938 0.06595025 +#> 4 0.09386198 -0.239239291 -0.079574652 0.004080677 0.23965275 +#> 5 -0.03540689 -0.032725874 0.209994611 -0.246674424 0.02757919 +#> 6 0.44890673 -0.325267423 -0.024517791 -0.050395249 -0.14357516 +#> iov.Cl(occ==2) iov.Ka(occ==1) iov.Ka(occ==2) V2 V3 TCl +#> 1 0.07218375 0.03039623 0.067693210 39.90301 297.153 18.10281 +#> 2 0.02406445 0.03465175 0.169113740 39.90301 297.153 18.10281 +#> 3 0.07833762 0.16896481 0.083329437 39.90301 297.153 18.10281 +#> 4 0.09014535 0.16781970 -0.007580041 39.90301 297.153 18.10281 +#> 5 -0.02744128 -0.05331629 0.123470046 39.90301 297.153 18.10281 +#> 6 0.14006037 0.16503842 -0.069874068 39.90301 297.153 18.10281 +#> eta.Cl TKA eta.Ka Q Kin Kout EC50 +#> 1 0.3276499 -0.3669389 0.1976122 10.56335 0.9466661 1.471005 199.9767 +#> 2 -0.1956677 -0.3669389 -0.4448090 10.56335 0.9466661 1.471005 199.9767 +#> 3 -0.7690862 -0.3669389 0.4423792 10.56335 0.9466661 1.471005 199.9767 +#> 4 -0.2558634 -0.3669389 -0.2013753 10.56335 0.9466661 1.471005 199.9767 +#> 5 -0.6370408 -0.3669389 -0.2217999 10.56335 0.9466661 1.471005 199.9767 +#> 6 -0.2844281 -0.3669389 0.2746496 10.56335 0.9466661 1.471005 199.9767 
 print(head(s$params %>% filter(sim.id == 2)))
#>   sim.id id inv.Cl(inv==1) inv.Cl(inv==2) inv.Ka(inv==1) inv.Ka(inv==2)
-#> 1      2  1    -0.04491481    -0.09395214     0.08965191      0.1265575
-#> 2      2  2    -0.04491481    -0.09395214     0.08965191      0.1265575
-#> 3      2  3    -0.04491481    -0.09395214     0.08965191      0.1265575
-#> 4      2  4    -0.04491481    -0.09395214     0.08965191      0.1265575
-#> 5      2  5    -0.04491481    -0.09395214     0.08965191      0.1265575
-#> 6      2  6    -0.04491481    -0.09395214     0.08965191      0.1265575
+#> 1      2  1     -0.2185114      0.1578254    -0.06550178     0.01692558
+#> 2      2  2     -0.2185114      0.1578254    -0.06550178     0.01692558
+#> 3      2  3     -0.2185114      0.1578254    -0.06550178     0.01692558
+#> 4      2  4     -0.2185114      0.1578254    -0.06550178     0.01692558
+#> 5      2  5     -0.2185114      0.1578254    -0.06550178     0.01692558
+#> 6      2  6     -0.2185114      0.1578254    -0.06550178     0.01692558
 #>   eye.Cl(eye==1) eye.Cl(eye==2) eye.Ka(eye==1) eye.Ka(eye==2) iov.Cl(occ==1)
-#> 1    -0.32697281     0.05799824     0.05028534    0.302033419    -0.10995295
-#> 2    -0.02159235     0.06495060     0.28662841    0.061231871    -0.03617266
-#> 3    -0.30216008     0.17484210    -0.03947689   -0.050076485    -0.07469975
-#> 4     0.15415822    -0.12064344    -0.29445326   -0.185026088    -0.11227958
-#> 5     0.09671987    -0.08665433    -0.07282272   -0.241574148    -0.17869466
-#> 6     0.05892414    -0.15623698    -0.08837725    0.006157003     0.15371362
-#>   iov.Cl(occ==2) iov.Ka(occ==1) iov.Ka(occ==2)       V2       V3      TCl
-#> 1   -0.112893048    0.098532914     0.05867914 41.14554 297.2317 19.29969
-#> 2   -0.003219473   -0.258834701    -0.07328102 41.14554 297.2317 19.29969
-#> 3   -0.163476114   -0.141774495    -0.03129942 41.14554 297.2317 19.29969
-#> 4    0.145940005   -0.008140622    -0.07572177 41.14554 297.2317 19.29969
-#> 5   -0.098236212    0.064253865    -0.03018284 41.14554 297.2317 19.29969
-#> 6    0.065147255   -0.078717810     0.05578569 41.14554 297.2317 19.29969
-#>       eta.Cl       TKA      eta.Ka        Q      Kin     Kout     EC50
-#> 1  0.1955688 -0.145662 -0.37850798 10.31685 1.759972 1.026146 199.8189
-#> 2  0.5163013 -0.145662  0.01158123 10.31685 1.759972 1.026146 199.8189
-#> 3 -0.2067334 -0.145662 -0.38842622 10.31685 1.759972 1.026146 199.8189
-#> 4  0.1474554 -0.145662 -0.17572677 10.31685 1.759972 1.026146 199.8189
-#> 5 -0.4601038 -0.145662 -0.43805881 10.31685 1.759972 1.026146 199.8189
-#> 6  0.4399962 -0.145662  0.12118850 10.31685 1.759972 1.026146 199.8189
+#> 1 -0.28983275 0.23313282 0.054875269 -0.10816332 0.03378266 +#> 2 0.17133543 -0.09585557 -0.018382439 0.03009169 -0.03036841 +#> 3 -0.04487519 -0.10519202 0.300869327 0.13375274 0.05674318 +#> 4 0.19924316 0.02586329 -0.109179227 0.22221001 0.06869933 +#> 5 -0.05895218 -0.28987217 -0.007452707 -0.03639888 -0.03700882 +#> 6 0.18030544 -0.37938212 0.270230738 -0.15310814 -0.15591525 +#> iov.Cl(occ==2) iov.Ka(occ==1) iov.Ka(occ==2) V2 V3 TCl +#> 1 0.05942611 0.02503154 -0.11716174 39.484 297.4703 18.23602 +#> 2 0.07854405 0.12953177 0.08902964 39.484 297.4703 18.23602 +#> 3 -0.05471371 0.04489170 -0.01115435 39.484 297.4703 18.23602 +#> 4 0.01822086 0.29324185 0.09084004 39.484 297.4703 18.23602 +#> 5 -0.16679912 0.03565972 0.05666132 39.484 297.4703 18.23602 +#> 6 0.11982797 0.11883012 -0.01873016 39.484 297.4703 18.23602 +#> eta.Cl TKA eta.Ka Q Kin Kout EC50 +#> 1 -0.2606673 0.4157218 -0.113167108 10.59193 0.7312587 1.12052 200.1582 +#> 2 0.4088169 0.4157218 0.494133531 10.59193 0.7312587 1.12052 200.1582 +#> 3 -0.2175045 0.4157218 -0.002530923 10.59193 0.7312587 1.12052 200.1582 +#> 4 0.5150686 0.4157218 -0.121588025 10.59193 0.7312587 1.12052 200.1582 +#> 5 0.3760662 0.4157218 0.218664584 10.59193 0.7312587 1.12052 200.1582 +#> 6 0.3092382 0.4157218 0.065845127 10.59193 0.7312587 1.12052 200.1582

For between eye variability and between occasion variability each individual simulates a number of variables that become the between eye and between occasion variability; In the case of the eye:

diff --git a/articles/rxode2-pipeline.html b/articles/rxode2-pipeline.html index aab3ee0a0..e5676442f 100644 --- a/articles/rxode2-pipeline.html +++ b/articles/rxode2-pipeline.html @@ -157,7 +157,7 @@

Advanced Features, Model Types, Techni

rxode2 in a pipeline

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Source: vignettes/rxode2-pipeline.Rmd
rxode2-pipeline.Rmd
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Advanced Features, Model Types, Techni

Matthew Fidler

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Source: vignettes/rxode2-plot.Rmd
rxode2-plot.Rmd
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Advanced Features, Model Types, Techni

Using Prior Data for ODE solving

-

2023-11-28

+

2023-11-30

Source: vignettes/rxode2-prior-data.Rmd
rxode2-prior-data.Rmd
@@ -242,33 +242,33 @@

Using prior data for solving#> ── Solved rxode2 object ── #> ── Parameters ($params): ── #> # A tibble: 12 × 7 -#> id tka tcl tv eta.ka eta.cl eta.v -#> <fct> <dbl> <dbl> <dbl> <dbl> <dbl> <dbl> -#> 1 1 0.451 1.02 3.45 0.0844 -0.366 -0.129 -#> 2 2 0.451 1.02 3.45 0.286 -0.223 -0.00544 -#> 3 3 0.451 1.02 3.45 1.38 -0.258 -0.0442 -#> 4 4 0.451 1.02 3.45 0.745 -0.228 0.162 -#> 5 5 0.451 1.02 3.45 0.384 -0.000858 0.0493 -#> 6 6 0.451 1.02 3.45 -2.45 0.442 0.305 -#> 7 7 0.451 1.02 3.45 0.524 -0.784 0.0160 -#> 8 8 0.451 1.02 3.45 0.0609 -0.117 -0.233 -#> 9 9 0.451 1.02 3.45 -0.750 -0.370 -0.457 -#> 10 10 0.451 1.02 3.45 0.0168 0.101 0.0964 -#> 11 11 0.451 1.02 3.45 0.248 -0.233 0.112 -#> 12 12 0.451 1.02 3.45 0.157 0.127 -0.591 +#> id tka tcl tv eta.ka eta.cl eta.v +#> <fct> <dbl> <dbl> <dbl> <dbl> <dbl> <dbl> +#> 1 1 0.451 1.02 3.45 -0.431 0.185 0.143 +#> 2 2 0.451 1.02 3.45 0.0585 -0.518 -0.127 +#> 3 3 0.451 1.02 3.45 0.710 -0.180 -0.130 +#> 4 4 0.451 1.02 3.45 1.16 0.0582 0.230 +#> 5 5 0.451 1.02 3.45 0.406 0.227 -0.0981 +#> 6 6 0.451 1.02 3.45 0.0960 0.0544 -0.658 +#> 7 7 0.451 1.02 3.45 -0.0790 0.519 0.0537 +#> 8 8 0.451 1.02 3.45 -1.70 -0.670 -0.118 +#> 9 9 0.451 1.02 3.45 -0.582 -0.546 -0.305 +#> 10 10 0.451 1.02 3.45 -0.275 -0.303 -0.298 +#> 11 11 0.451 1.02 3.45 0.564 -0.245 0.00526 +#> 12 12 0.451 1.02 3.45 0.126 0.353 0.211 #> ── Initial Conditions ($inits): ── #> depot center #> 0 0 #> ── First part of data (object): ── #> # A tibble: 132 × 8 -#> id time ka cl v cp depot center -#> <int> <dbl> <dbl> <dbl> <dbl> <dbl> <dbl> <dbl> -#> 1 1 0 1.71 1.92 27.7 0 320. 0 -#> 2 1 0.25 1.71 1.92 27.7 3.98 209. 110. -#> 3 1 0.57 1.71 1.92 27.7 7.04 121. 195. -#> 4 1 1.12 1.71 1.92 27.7 9.38 47.2 259. -#> 5 1 2.02 1.71 1.92 27.7 10.1 10.2 279. -#> 6 1 3.82 1.71 1.92 27.7 9.24 0.469 255. +#> id time ka cl v cp depot center +#> <int> <dbl> <dbl> <dbl> <dbl> <dbl> <dbl> <dbl> +#> 1 1 0 1.02 3.33 36.3 0 320. 0 +#> 2 1 0.25 1.02 3.33 36.3 1.96 248. 71.2 +#> 3 1 0.57 1.02 3.33 36.3 3.78 179. 137. +#> 4 1 1.12 1.02 3.33 36.3 5.65 102. 205. +#> 5 1 2.02 1.02 3.33 36.3 6.81 40.8 247. +#> 6 1 3.82 1.02 3.33 36.3 6.63 6.50 241. #> # ℹ 126 more rows ## Of course the fasest way to solve if you don't care about the rxode2 extra parameters is @@ -282,31 +282,31 @@

Using prior data for solving#> # A tibble: 132 × 8 #> id time ka cl v cp depot center #> <int> <dbl> <dbl> <dbl> <dbl> <dbl> <dbl> <dbl> -#> 1 1 0 1.90 3.99 45.5 0 3.20e+2 0 -#> 2 1 0.25 1.90 3.99 45.5 2.62 1.99e+2 119. -#> 3 1 0.57 1.90 3.99 45.5 4.51 1.09e+2 205. -#> 4 1 1.12 1.90 3.99 45.5 5.80 3.83e+1 264. -#> 5 1 2.02 1.90 3.99 45.5 6.02 6.96e+0 274. -#> 6 1 3.82 1.90 3.99 45.5 5.27 2.30e-1 240. -#> 7 1 5.1 1.90 3.99 45.5 4.72 2.03e-2 215. -#> 8 1 7.03 1.90 3.99 45.5 3.98 5.24e-4 181. -#> 9 1 9.05 1.90 3.99 45.5 3.34 1.14e-5 152. -#> 10 1 12.1 1.90 3.99 45.5 2.55 3.37e-8 116. +#> 1 1 0 2.30 1.43 38.7 0 3.20e+2 0 +#> 2 1 0.25 2.30 1.43 38.7 3.60 1.80e+2 139. +#> 3 1 0.57 2.30 1.43 38.7 5.96 8.62e+1 231. +#> 4 1 1.12 2.30 1.43 38.7 7.42 2.43e+1 287. +#> 5 1 2.02 2.30 1.43 38.7 7.72 3.07e+0 299. +#> 6 1 3.82 2.30 1.43 38.7 7.30 4.87e-2 282. +#> 7 1 5.1 2.30 1.43 38.7 6.96 2.56e-3 269. +#> 8 1 7.03 2.30 1.43 38.7 6.48 3.02e-5 251. +#> 9 1 9.05 2.30 1.43 38.7 6.02 2.89e-7 233. +#> 10 1 12.1 2.30 1.43 38.7 5.37 1.54e-9 208. #> # ℹ 122 more rows data.table::data.table(solveData) -#> id time ka cl v cp depot center -#> 1: 1 0.00 1.895099 3.987523 45.47526 0.0000000 3.199920e+02 0.00000 -#> 2: 1 0.25 1.895099 3.987523 45.47526 2.6241287 1.992422e+02 119.33294 -#> 3: 1 0.57 1.895099 3.987523 45.47526 4.5132815 1.086455e+02 205.24265 -#> 4: 1 1.12 1.895099 3.987523 45.47526 5.8044894 3.831280e+01 263.96067 -#> 5: 1 2.02 1.895099 3.987523 45.47526 6.0198854 6.960095e+00 273.75586 -#> --- -#> 128: 12 5.07 4.299781 2.744429 25.14956 7.5229329 1.098088e-07 189.19843 -#> 129: 12 7.07 4.299781 2.744429 25.14956 6.0478778 -1.176117e-09 152.10145 -#> 130: 12 9.03 4.299781 2.744429 25.14956 4.8833079 -2.115089e-09 122.81303 -#> 131: 12 12.05 4.299781 2.744429 25.14956 3.5122972 2.455099e-09 88.33272 -#> 132: 12 24.15 4.299781 2.744429 25.14956 0.9378821 1.006647e-08 23.58732

+#> id time ka cl v cp depot center +#> 1: 1 0.00 2.300935 1.427091 38.71162 0.000000 3.199920e+02 0.00000 +#> 2: 1 0.25 2.300935 1.427091 38.71162 3.597596 1.800190e+02 139.26877 +#> 3: 1 0.57 2.300935 1.427091 38.71162 5.962771 8.620795e+01 230.82849 +#> 4: 1 1.12 2.300935 1.427091 38.71162 7.422420 2.431874e+01 287.33387 +#> 5: 1 2.02 2.300935 1.427091 38.71162 7.717302 3.066092e+00 298.74922 +#> --- +#> 128: 12 5.07 2.042580 3.811162 47.41169 4.683446 1.019822e-02 222.05007 +#> 129: 12 7.07 2.042580 3.811162 47.41169 3.988089 1.715374e-04 189.08201 +#> 130: 12 9.03 2.042580 3.811162 47.41169 3.406753 3.130922e-06 161.51988 +#> 131: 12 12.05 2.042580 3.811162 47.41169 2.672458 6.357558e-09 126.70572 +#> 132: 12 24.15 2.042580 3.811162 47.41169 1.010399 -4.063231e-09 47.90474
diff --git a/articles/rxode2-prior-data_files/figure-html/unnamed-chunk-5-1.png b/articles/rxode2-prior-data_files/figure-html/unnamed-chunk-5-1.png index 5e38bf699..0e2548395 100644 Binary files a/articles/rxode2-prior-data_files/figure-html/unnamed-chunk-5-1.png and b/articles/rxode2-prior-data_files/figure-html/unnamed-chunk-5-1.png differ diff --git a/articles/rxode2-rxUse.html b/articles/rxode2-rxUse.html index a7226d7f9..7a9a1d2f8 100644 --- a/articles/rxode2-rxUse.html +++ b/articles/rxode2-rxUse.html @@ -159,7 +159,7 @@
Advanced Features, Model Types, Techni

Matthew Fidler

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2023-11-28

+

2023-11-30

Source: vignettes/rxode2-rxUse.Rmd
rxode2-rxUse.Rmd
diff --git a/articles/rxode2-shiny.html b/articles/rxode2-shiny.html index a7b3cf592..71879b2fd 100644 --- a/articles/rxode2-shiny.html +++ b/articles/rxode2-shiny.html @@ -157,7 +157,7 @@
Advanced Features, Model Types, Techni

rxode2 and Shiny

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2023-11-28

+

2023-11-30

Source: vignettes/rxode2-shiny.Rmd
rxode2-shiny.Rmd
diff --git a/articles/rxode2-sim-var.html b/articles/rxode2-sim-var.html index e3dd49b16..597a80bec 100644 --- a/articles/rxode2-sim-var.html +++ b/articles/rxode2-sim-var.html @@ -157,7 +157,7 @@
Advanced Features, Model Types, Techni

rxode2 Simulation

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2023-11-28

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2023-11-30

Source: vignettes/rxode2-sim-var.Rmd
rxode2-sim-var.Rmd
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Advanced Features, Model Types, Techni

Single Subject ODE solving -- differences from multiple subject

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2023-11-28

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2023-11-30

Source: vignettes/rxode2-single-subject.Rmd
rxode2-single-subject.Rmd
diff --git a/articles/rxode2-single-subject_files/figure-html/unnamed-chunk-5-1.png b/articles/rxode2-single-subject_files/figure-html/unnamed-chunk-5-1.png index fba81cd7f..74fab59ec 100644 Binary files a/articles/rxode2-single-subject_files/figure-html/unnamed-chunk-5-1.png and b/articles/rxode2-single-subject_files/figure-html/unnamed-chunk-5-1.png differ diff --git a/articles/rxode2-single-subject_files/figure-html/unnamed-chunk-6-1.png b/articles/rxode2-single-subject_files/figure-html/unnamed-chunk-6-1.png index 4415e8355..d08312dc4 100644 Binary files a/articles/rxode2-single-subject_files/figure-html/unnamed-chunk-6-1.png and b/articles/rxode2-single-subject_files/figure-html/unnamed-chunk-6-1.png differ diff --git a/articles/rxode2-speed.html b/articles/rxode2-speed.html index d17010558..fe369dd6a 100644 --- a/articles/rxode2-speed.html +++ b/articles/rxode2-speed.html @@ -159,7 +159,7 @@
Advanced Features, Model Types, Techni

Matthew Fidler

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2023-11-28

+

2023-11-30

Source: vignettes/rxode2-speed.Rmd
rxode2-speed.Rmd
@@ -262,8 +262,8 @@

A note about t output. You can see the differences below:

 summary(mod1$simulationModel)
-#> rxode2 2.0.14.9000 model named rx_1db0dc8e0f01971bbf76da7db21b2ddc model (✔ ready). 
-#> DLL: /tmp/RtmprYXrJy/rxode2/rx_1db0dc8e0f01971bbf76da7db21b2ddc__.rxd/rx_1db0dc8e0f01971bbf76da7db21b2ddc_.so
+#> rxode2 2.0.14.9000 model named rx_dc699e1c896b208ee1d2c3d40f0517f6 model (✔ ready). 
+#> DLL: /tmp/RtmphFlXM3/rxode2/rx_dc699e1c896b208ee1d2c3d40f0517f6__.rxd/rx_dc699e1c896b208ee1d2c3d40f0517f6_.so
 #> NULL
 #> 
 #> Calculated Variables:
@@ -281,8 +281,8 @@ 
A note about t
 #> })
 summary(mod1$simulationIniModel)
 #> using C compiler: ‘gcc (Ubuntu 11.4.0-1ubuntu1~22.04) 11.4.0’
-#> rxode2 2.0.14.9000 model named rx_5a1faf720b150ea8bf052c9e377d3541 model (✔ ready). 
-#> DLL: /tmp/RtmprYXrJy/rxode2/rx_5a1faf720b150ea8bf052c9e377d3541__.rxd/rx_5a1faf720b150ea8bf052c9e377d3541_.so
+#> rxode2 2.0.14.9000 model named rx_a70bc38d73df7fd8798a4d16d23549b7 model (✔ ready). 
+#> DLL: /tmp/RtmphFlXM3/rxode2/rx_a70bc38d73df7fd8798a4d16d23549b7__.rxd/rx_a70bc38d73df7fd8798a4d16d23549b7_.so
 #> NULL
 #> 
 #> Calculated Variables:
@@ -308,8 +308,8 @@ 
A note about t
 #> })
 summary(mod2$simulationModel)
 #> using C compiler: ‘gcc (Ubuntu 11.4.0-1ubuntu1~22.04) 11.4.0’
-#> rxode2 2.0.14.9000 model named rx_89c321f08eb652c4c20174fabb507c1a model (✔ ready). 
-#> DLL: /tmp/RtmprYXrJy/rxode2/rx_89c321f08eb652c4c20174fabb507c1a__.rxd/rx_89c321f08eb652c4c20174fabb507c1a_.so
+#> rxode2 2.0.14.9000 model named rx_4f35e2e99d243ab6809555688909b8b5 model (✔ ready). 
+#> DLL: /tmp/RtmphFlXM3/rxode2/rx_4f35e2e99d243ab6809555688909b8b5__.rxd/rx_4f35e2e99d243ab6809555688909b8b5_.so
 #> NULL
 #> 
 #> Calculated Variables:
@@ -365,8 +365,8 @@ 
A note about t
 #> })
 summary(mod2$simulationIniModel)
 #> using C compiler: ‘gcc (Ubuntu 11.4.0-1ubuntu1~22.04) 11.4.0’
-#> rxode2 2.0.14.9000 model named rx_2df8872b4615f9e177c35609e2b4f0ac model (✔ ready). 
-#> DLL: /tmp/RtmprYXrJy/rxode2/rx_2df8872b4615f9e177c35609e2b4f0ac__.rxd/rx_2df8872b4615f9e177c35609e2b4f0ac_.so
+#> rxode2 2.0.14.9000 model named rx_6e671c0a1d256755528eea1281ce8326 model (✔ ready). 
+#> DLL: /tmp/RtmphFlXM3/rxode2/rx_6e671c0a1d256755528eea1281ce8326__.rxd/rx_6e671c0a1d256755528eea1281ce8326_.so
 #> NULL
 #> 
 #> Calculated Variables:
@@ -552,10 +552,10 @@ 
Compare the times between all
 print(bench)
 #> Unit: milliseconds
 #>               expr       min        lq      mean    median        uq       max
-#>           runFor() 276.22910 280.46886 291.73762 283.01823 286.89760 451.35924
-#>        runSapply() 275.08853 280.51578 290.80704 282.79888 287.13135 398.02833
-#>  runSingleThread()  30.18147  30.41170  32.09662  30.53664  30.91048  54.01280
-#>       run2Thread()  17.77206  18.07482  19.55270  18.23813  18.59497  33.42291
+#>           runFor() 270.69599 276.55658 287.34527 279.04749 283.91232 399.33829
+#>        runSapply() 270.92489 277.10728 286.33457 279.31426 284.37742 395.99029
+#>  runSingleThread()  28.37033  28.55639  29.56166  28.67460  28.90486  47.37217
+#>       run2Thread()  16.90444  17.11417  18.66124  17.29484  17.65497  29.40771
 #>  neval
 #>    100
 #>    100
@@ -582,10 +582,10 @@ 
Compare the times between all
 print(bench)
 #> Unit: milliseconds
 #>          expr      min       lq     mean   median       uq      max neval
-#>  runThread(1) 30.11232 30.44157 32.17729 30.87135 31.89442 53.22333   100
-#>  runThread(2) 18.01286 18.35992 20.01757 19.03389 19.27335 30.26586   100
-#>  runThread(3) 19.16968 20.63224 21.16056 20.88685 21.64686 26.72507   100
-#>  runThread(4) 17.32244 17.52879 19.31132 18.24037 18.41109 33.27417   100
+#> runThread(1) 28.50206 28.80758 30.07428 29.76448 30.28849 51.17343 100 +#> runThread(2) 16.99616 17.40397 19.68778 18.00946 19.60652 29.88473 100 +#> runThread(3) 18.74504 19.83795 20.51225 20.06909 20.67744 28.24697 100 +#> runThread(4) 16.64245 16.94800 19.28947 17.38783 17.77615 38.09974 100

 autoplot(bench)

@@ -675,7 +675,7 @@

A real life exampleStoplapply <- Sys.time() print(Stoplapply - Startlapply) -#> Time difference of 12.63246 secs

+#> Time difference of 12.56756 secs

By applying some of the new parallel solving concepts you can simply run the same simulation both with less code and faster:

@@ -716,7 +716,7 @@ 
A real life exampleres <- rxSolve(rx, ev, omega=omega, returnType="data.table")
 endParallel <- Sys.time()
 print(endParallel - startParallel)
-#> Time difference of 0.1095562 secs
+#> Time difference of 0.1166935 secs

You can see a striking time difference between the two methods; A few things to keep in mind: