diff --git a/.github/test-spec.yml b/.github/test-spec.yml
index 687726761493..d30579de542f 100644
--- a/.github/test-spec.yml
+++ b/.github/test-spec.yml
@@ -599,3 +599,20 @@
   - "samples/nrf_rpc/protocols_serialization/**/*"
   - "subsys/net/openthread/rpc/**/*"
   - "subsys/nrf_rpc/**/*"
+
+"CI-secdom-test":
+  - "samples/bluetooth/multiple_adv_sets/**/*"
+  - "samples/nfc/record_text/**/*"
+  - "samples/app_event_manager/**/*"
+  - "samples/sdfw/ssf_client/**/*"
+  - "lib/dk_buttons_and_leds/**/*"
+  - "subsys/app_event_manager/**/*"
+  - "include/nfc/ndef/msg.h"
+  - "include/nfc/ndef/record.h"
+  - "include/nfc/ndef/text_rec.h"
+  - "include/dk_buttons_and_leds.h"
+  - "include/sdfw/sdfw_services/echo_service.h"
+  - "include/sdfw/sdfw_services/reset_evt_service.h"
+  - "include/sdfw/sdfw_services/sdfw_update_service.h"
+  - "include/app_event_manager/app_event_manager.h"
+  - "include/sdfw/sdfw_services/ssf_errno.h"