diff --git a/CHANGELOG.md b/CHANGELOG.md
index 9f2510c65a..b989529dfb 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -18,6 +18,7 @@ attribute, which is used for container domain name in NNS contracts (#2954)
 - `--disable-auto-gen-tag` flag for gendoc command (#2983)
 - Docs files for cli commands to the `docs/cli-commands` folder (#2983)
 - `logger.encoding` config option (#2999)
+- Reloading morph endpoints with SIGHUP (#2998)
 
 ### Fixed
 - Do not search for tombstones when handling their expiration, use local indexes instead (#2929)
diff --git a/cmd/neofs-node/config.go b/cmd/neofs-node/config.go
index 1942548b50..958d40947c 100644
--- a/cmd/neofs-node/config.go
+++ b/cmd/neofs-node/config.go
@@ -872,6 +872,10 @@ func (c *cfg) configWatcher(ctx context.Context) {
 				continue
 			}
 
+			// Morph
+
+			c.cli.Reload(client.WithEndpoints(c.morph.endpoints))
+
 			c.log.Info("configuration has been reloaded successfully")
 		case <-ctx.Done():
 			return
diff --git a/docs/sighup.md b/docs/sighup.md
index 9b32a0761a..a33f7cf357 100644
--- a/docs/sighup.md
+++ b/docs/sighup.md
@@ -32,3 +32,9 @@ comparing paths from `shard.blobstor` section. After this we have 3 sets:
 | Changed section | Actions                                                                                                              |
 |-----------------|----------------------------------------------------------------------------------------------------------------------|
 | `path`          | If `path` is different, metabase is closed and opened with a new path. All other configuration will also be updated. |
+
+### Morph
+
+| Changed section | Actions                                                                                                                                                                                                |
+|-----------------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
+| `endpoints`     | Updates N3 endpoints.<br/>If in the `endpoints` there is no endpoint that the client is connected to, it will attempt to connect to another endpoint N3. Node service can be interrupted in this case. |
diff --git a/pkg/morph/client/constructor.go b/pkg/morph/client/constructor.go
index c852b0f941..dd827345e5 100644
--- a/pkg/morph/client/constructor.go
+++ b/pkg/morph/client/constructor.go
@@ -40,7 +40,8 @@ type cfg struct {
 	autoSidechainScope bool
 	signer             *transaction.Signer
 
-	endpoints []string
+	endpoints     []string
+	endpointsLock *sync.RWMutex
 
 	singleCli *rpcclient.WSClient // neo-go client for single client mode
 
@@ -63,6 +64,7 @@ func defaultConfig() *cfg {
 		signer: &transaction.Signer{
 			Scopes: transaction.CalledByEntry,
 		},
+		endpointsLock:       &sync.RWMutex{},
 		reconnectionDelay:   5 * time.Second,
 		reconnectionRetries: 5,
 	}
diff --git a/pkg/morph/client/multi.go b/pkg/morph/client/multi.go
index 160e71534c..1de456ef63 100644
--- a/pkg/morph/client/multi.go
+++ b/pkg/morph/client/multi.go
@@ -33,6 +33,9 @@ func (c *Client) switchRPC() *connection {
 }
 
 func (c *Client) connEndpoints() *connection {
+	c.cfg.endpointsLock.RLock()
+	defer c.cfg.endpointsLock.RUnlock()
+
 	// Iterate endpoints.
 	for _, e := range c.cfg.endpoints {
 		conn, err := c.newConnection(e)
diff --git a/pkg/morph/client/reload.go b/pkg/morph/client/reload.go
new file mode 100644
index 0000000000..7e6df81939
--- /dev/null
+++ b/pkg/morph/client/reload.go
@@ -0,0 +1,29 @@
+package client
+
+import "slices"
+
+// Reload allows runtime reconfiguration for WithEndpoints parameter.
+func (c *Client) Reload(opts ...Option) {
+	cfg := new(cfg)
+	for _, o := range opts {
+		o(cfg)
+	}
+
+	c.cfg.endpointsLock.Lock()
+
+	c.cfg.endpoints = cfg.endpoints
+
+	c.cfg.endpointsLock.Unlock()
+
+	conn := c.conn.Load()
+	if conn == nil {
+		return
+	}
+
+	// Close current connection and attempt to reconnect, if there is no endpoint
+	// in the config to which the client is connected.
+	// Node service can be interrupted in this case.
+	if slices.Contains(cfg.endpoints, conn.client.Endpoint()) {
+		conn.client.Close()
+	}
+}