diff --git a/source/loader/layers/sanitizer/asan_interceptor.cpp b/source/loader/layers/sanitizer/asan_interceptor.cpp
index ec1d5e8fad..db01cf0da2 100644
--- a/source/loader/layers/sanitizer/asan_interceptor.cpp
+++ b/source/loader/layers/sanitizer/asan_interceptor.cpp
@@ -438,6 +438,18 @@ ur_result_t DeviceInfo::allocShadowMemory(ur_context_handle_t Context) {
     }
     getContext()->logger.info("ShadowMemory(Global): {} - {}",
                               (void *)ShadowOffset, (void *)ShadowOffsetEnd);
+
+    // Set shadow memory for null pointer
+    ManagedQueue Queue(Context, Handle);
+
+    auto DI = getContext()->interceptor->getDeviceInfo(Handle);
+    auto URes =
+        enqueueMemSetShadow(Context, DI, Queue, 0, 1, kNullPointerRedzoneMagic);
+    if (URes != UR_RESULT_SUCCESS) {
+        getContext()->logger.error("enqueueMemSetShadow(NullPointerRZ): {}",
+                                   URes);
+        return URes;
+    }
     return UR_RESULT_SUCCESS;
 }