diff --git a/instrumentation/aws_sdk/lib/opentelemetry/instrumentation/aws_sdk/instrumentation.rb b/instrumentation/aws_sdk/lib/opentelemetry/instrumentation/aws_sdk/instrumentation.rb
index 07b4075f2..6173074b2 100644
--- a/instrumentation/aws_sdk/lib/opentelemetry/instrumentation/aws_sdk/instrumentation.rb
+++ b/instrumentation/aws_sdk/lib/opentelemetry/instrumentation/aws_sdk/instrumentation.rb
@@ -10,10 +10,11 @@ module AwsSdk
       # Instrumentation class that detects and installs the AwsSdk instrumentation
       class Instrumentation < OpenTelemetry::Instrumentation::Base
         MINIMUM_VERSION = Gem::Version.new('2.0.0')
+        CURRENT_MAJOR_VERSION = Gem::Version.new('3.0.0')
 
         install do |_config|
           require_dependencies
-          add_plugin(Seahorse::Client::Base, *loaded_constants)
+          add_plugins(Seahorse::Client::Base, *loaded_constants)
         end
 
         present do
@@ -46,14 +47,42 @@ def require_dependencies
           require_relative 'messaging_helper'
         end
 
-        def add_plugin(*targets)
+        def add_plugins(*targets)
           targets.each { |klass| klass.add_plugin(AwsSdk::Plugin) }
         end
 
         def loaded_constants
+          if gem_version >= CURRENT_MAJOR_VERSION
+            load_v3_constants
+          else
+            load_legacy_constants
+          end
+        end
+
+        def load_v3_constants
+          ::Aws.constants.each_with_object([]) do |c, constants|
+            m = ::Aws.const_get(c)
+            next unless unloaded_service?(c, m)
+
+            begin
+              constants << m.const_get(:Client)
+            rescue StandardError => e
+              OpenTelemetry.logger.warn("Constant could not be loaded: #{e}")
+            end
+          end
+        end
+
+        def unloaded_service?(constant, service_module)
+          !::Aws.autoload?(constant) &&
+            service_module.is_a?(Module) &&
+            service_module.const_defined?(:Client) &&
+            (service_module.const_get(:Client).superclass == Seahorse::Client::Base)
+        end
+
+        def load_legacy_constants
           # Cross-check services against loaded AWS constants
           # Module#const_get can return a constant from ancestors when there's a miss.
-          # If this conincidentally matches another constant, it will attempt to patch
+          # If this coincidentally matches another constant, it will attempt to patch
           # the wrong constant, resulting in patch failure.
           available_services = ::Aws.constants & SERVICES.map(&:to_sym)
           available_services.each_with_object([]) do |service, constants|
diff --git a/instrumentation/aws_sdk/opentelemetry-instrumentation-aws_sdk.gemspec b/instrumentation/aws_sdk/opentelemetry-instrumentation-aws_sdk.gemspec
index 01415e31c..4fba14c34 100644
--- a/instrumentation/aws_sdk/opentelemetry-instrumentation-aws_sdk.gemspec
+++ b/instrumentation/aws_sdk/opentelemetry-instrumentation-aws_sdk.gemspec
@@ -20,8 +20,8 @@ Gem::Specification.new do |spec|
   spec.license     = 'Apache-2.0'
 
   spec.files = Dir.glob('lib/**/*.rb') +
-               Dir.glob('*.md') +
-               ['LICENSE', '.yardopts']
+    Dir.glob('*.md') +
+    ['LICENSE', '.yardopts']
   spec.require_paths = ['lib']
   spec.required_ruby_version = '>= 3.0'
 
@@ -29,6 +29,10 @@ Gem::Specification.new do |spec|
   spec.add_dependency 'opentelemetry-instrumentation-base', '~> 0.22.1'
 
   spec.add_development_dependency 'appraisal', '~> 2.5'
+  spec.add_development_dependency 'aws-sdk-dynamodb'
+  spec.add_development_dependency 'aws-sdk-s3'
+  spec.add_development_dependency 'aws-sdk-sns'
+  spec.add_development_dependency 'aws-sdk-sqs'
   spec.add_development_dependency 'bundler', '~> 2.4'
   spec.add_development_dependency 'minitest', '~> 5.0'
   spec.add_development_dependency 'opentelemetry-sdk', '~> 1.1'