diff --git a/.github/workflows/ci-instrumentation-canary.yml b/.github/workflows/ci-instrumentation-canary.yml
index 4dd45a722..ae32dd9bb 100644
--- a/.github/workflows/ci-instrumentation-canary.yml
+++ b/.github/workflows/ci-instrumentation-canary.yml
@@ -33,6 +33,7 @@ jobs:
           - koala
           - lmdb
           - net_http
+          - httpx
           - rack
           - rails
           - restclient
diff --git a/.github/workflows/ci-instrumentation.yml b/.github/workflows/ci-instrumentation.yml
index b5bacdeb2..d06fe5d5b 100644
--- a/.github/workflows/ci-instrumentation.yml
+++ b/.github/workflows/ci-instrumentation.yml
@@ -34,6 +34,7 @@ jobs:
           - gruf
           - http
           - http_client
+          - httpx
           - koala
           - lmdb
           - net_http
diff --git a/.github/workflows/release-hook-on-closed.yml b/.github/workflows/release-hook-on-closed.yml
index 7b00cdc54..6a80f4146 100644
--- a/.github/workflows/release-hook-on-closed.yml
+++ b/.github/workflows/release-hook-on-closed.yml
@@ -18,7 +18,7 @@ jobs:
       - name: Checkout repo
         uses: actions/checkout@v4
       - name: Install Toys
-        run: "gem install --no-document toys -v 0.15.1"
+        run: "gem install --no-document toys -v 0.15.3"
       - name: Process release request
         env:
           GITHUB_TOKEN: ${{ secrets.GITHUB_TOKEN }}
diff --git a/.github/workflows/release-hook-on-push.yml b/.github/workflows/release-hook-on-push.yml
index 23ed4912c..d3a85043d 100644
--- a/.github/workflows/release-hook-on-push.yml
+++ b/.github/workflows/release-hook-on-push.yml
@@ -19,7 +19,7 @@ jobs:
       - name: Checkout repo
         uses: actions/checkout@v4
       - name: Install Toys
-        run: "gem install --no-document toys -v 0.15.1"
+        run: "gem install --no-document toys -v 0.15.3"
       - name: Update open releases
         env:
           GITHUB_TOKEN: ${{ secrets.GITHUB_TOKEN }}
diff --git a/.github/workflows/release-perform.yml b/.github/workflows/release-perform.yml
index 105ae542c..60ebeaee5 100644
--- a/.github/workflows/release-perform.yml
+++ b/.github/workflows/release-perform.yml
@@ -28,7 +28,7 @@ jobs:
       - name: Checkout repo
         uses: actions/checkout@v4
       - name: Install Toys
-        run: "gem install --no-document toys -v 0.15.1"
+        run: "gem install --no-document toys -v 0.15.3"
       - name: Perform release
         env:
           GITHUB_TOKEN: ${{ secrets.GITHUB_TOKEN }}
diff --git a/.github/workflows/release-request.yml b/.github/workflows/release-request.yml
index f0ab20957..00997a9ba 100644
--- a/.github/workflows/release-request.yml
+++ b/.github/workflows/release-request.yml
@@ -22,7 +22,7 @@ jobs:
       - name: Checkout repo
         uses: actions/checkout@v4
       - name: Install Toys
-        run: "gem install --no-document toys -v 0.15.1"
+        run: "gem install --no-document toys -v 0.15.3"
       - name: Open release pull request
         env:
           GITHUB_TOKEN: ${{ secrets.GITHUB_TOKEN }}
diff --git a/.github/workflows/release-retry.yml b/.github/workflows/release-retry.yml
index 7b8d42afe..381987aec 100644
--- a/.github/workflows/release-retry.yml
+++ b/.github/workflows/release-retry.yml
@@ -25,7 +25,7 @@ jobs:
       - name: Checkout repo
         uses: actions/checkout@v4
       - name: Install Toys
-        run: "gem install --no-document toys -v 0.15.1"
+        run: "gem install --no-document toys -v 0.15.3"
       - name: Retry release
         env:
           GITHUB_TOKEN: ${{ secrets.GITHUB_TOKEN }}
diff --git a/.toys/.data/releases.yml b/.toys/.data/releases.yml
index 4cb72bc97..30d6cde6c 100644
--- a/.toys/.data/releases.yml
+++ b/.toys/.data/releases.yml
@@ -6,6 +6,7 @@ repo: open-telemetry/opentelemetry-ruby-contrib
 main_branch: main
 # Time in seconds for release scripts to wait for CI to complete.
 required_checks_timeout: 1200
+required_jobs: "^(ci|CI).*"
 # Git user attached to commits for release pull requests.
 git_user_name: Ariel Valentin
 git_user_email: ariel@arielvalentin.com
@@ -106,6 +107,10 @@ gems:
     directory: instrumentation/http_client
     version_constant: [OpenTelemetry, Instrumentation, HttpClient, VERSION]
 
+  - name: opentelemetry-instrumentation-httpx
+    directory: instrumentation/httpx
+    version_constant: [OpenTelemetry, Instrumentation, HTTPX, VERSION]
+
   - name: opentelemetry-instrumentation-koala
     directory: instrumentation/koala
     version_constant: [OpenTelemetry, Instrumentation, Koala, VERSION]
diff --git a/.toys/.toys.rb b/.toys/.toys.rb
index 11f265b72..d723a7a4a 100644
--- a/.toys/.toys.rb
+++ b/.toys/.toys.rb
@@ -1,7 +1,7 @@
-toys_version! "0.15.1"
+toys_version! "0.15.3"
 
 load_git remote: "https://github.com/dazuma/toys.git",
          path: ".toys/release",
          as: "release",
-         commit: "toys/v0.15.1",
+         commit: "toys/v0.15.3",
          update: 3600
diff --git a/CODEOWNERS b/CODEOWNERS
index ff2a9eb21..8c2435bb4 100644
--- a/CODEOWNERS
+++ b/CODEOWNERS
@@ -22,6 +22,8 @@ instrumentation/grape/ @muripic @fbogsany @mwear @robertlaurin @dazuma @ericmust
 
 instrumentation/graphql/ @swalkinshaw @rmosolgo @fbogsany @mwear @robertlaurin @dazuma @ericmustin @arielvalentin @ahayworth @plantfansam @robbkidd
 
+instrumentation/httpx/ @HoneyryderChuck @fbogsany @mwear @robertlaurin @dazuma @ericmustin @arielvalentin @ahayworth @plantfansam @robbkidd
+
 instrumentation/mongo/ @johnnyshields @fbogsany @mwear @robertlaurin @dazuma @ericmustin @arielvalentin @ahayworth @plantfansam @robbkidd
 
 instrumentation/racecar/ @chrisholmes @fbogsany @mwear @robertlaurin @dazuma @ericmustin @arielvalentin @ahayworth @plantfansam @robbkidd
diff --git a/instrumentation/httpx/.yardopts b/instrumentation/httpx/.yardopts
new file mode 100644
index 000000000..66530b20f
--- /dev/null
+++ b/instrumentation/httpx/.yardopts
@@ -0,0 +1,9 @@
+--no-private
+--title=OpenTelemetry HTTPX Instrumentation
+--markup=markdown
+--main=README.md
+./lib/opentelemetry/instrumentation/**/*.rb
+./lib/opentelemetry/instrumentation.rb
+-
+README.md
+CHANGELOG.md
diff --git a/instrumentation/httpx/Appraisals b/instrumentation/httpx/Appraisals
new file mode 100644
index 000000000..6d5b4793c
--- /dev/null
+++ b/instrumentation/httpx/Appraisals
@@ -0,0 +1,13 @@
+# frozen_string_literal: true
+
+# Copyright The OpenTelemetry Authors
+#
+# SPDX-License-Identifier: Apache-2.0
+
+appraise 'httpx-1' do
+  gem 'httpx', '~> 1.0'
+end
+
+appraise 'httpx-0' do
+  gem 'httpx', '~> 0.24'
+end
diff --git a/instrumentation/httpx/CHANGELOG.md b/instrumentation/httpx/CHANGELOG.md
new file mode 100644
index 000000000..8f13d82f7
--- /dev/null
+++ b/instrumentation/httpx/CHANGELOG.md
@@ -0,0 +1,5 @@
+# Release History: opentelemetry-instrumentation-httpx
+
+### v0.1.0 / 2023-11-06
+
+* Initial Release.
diff --git a/instrumentation/httpx/Gemfile b/instrumentation/httpx/Gemfile
new file mode 100644
index 000000000..8b038cdcb
--- /dev/null
+++ b/instrumentation/httpx/Gemfile
@@ -0,0 +1,14 @@
+# frozen_string_literal: true
+
+# Copyright The OpenTelemetry Authors
+#
+# SPDX-License-Identifier: Apache-2.0
+
+source 'https://rubygems.org'
+
+gemspec
+
+group :test do
+  gem 'opentelemetry-instrumentation-base', path: '../base'
+  gem 'pry-byebug', platform: 'ruby'
+end
diff --git a/instrumentation/httpx/LICENSE b/instrumentation/httpx/LICENSE
new file mode 100644
index 000000000..1ef7dad2c
--- /dev/null
+++ b/instrumentation/httpx/LICENSE
@@ -0,0 +1,201 @@
+                                 Apache License
+                           Version 2.0, January 2004
+                        http://www.apache.org/licenses/
+
+   TERMS AND CONDITIONS FOR USE, REPRODUCTION, AND DISTRIBUTION
+
+   1. Definitions.
+
+      "License" shall mean the terms and conditions for use, reproduction,
+      and distribution as defined by Sections 1 through 9 of this document.
+
+      "Licensor" shall mean the copyright owner or entity authorized by
+      the copyright owner that is granting the License.
+
+      "Legal Entity" shall mean the union of the acting entity and all
+      other entities that control, are controlled by, or are under common
+      control with that entity. For the purposes of this definition,
+      "control" means (i) the power, direct or indirect, to cause the
+      direction or management of such entity, whether by contract or
+      otherwise, or (ii) ownership of fifty percent (50%) or more of the
+      outstanding shares, or (iii) beneficial ownership of such entity.
+
+      "You" (or "Your") shall mean an individual or Legal Entity
+      exercising permissions granted by this License.
+
+      "Source" form shall mean the preferred form for making modifications,
+      including but not limited to software source code, documentation
+      source, and configuration files.
+
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+      transformation or translation of a Source form, including but
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+      and conversions to other media types.
+
+      "Work" shall mean the work of authorship, whether in Source or
+      Object form, made available under the License, as indicated by a
+      copyright notice that is included in or attached to the work
+      (an example is provided in the Appendix below).
+
+      "Derivative Works" shall mean any work, whether in Source or Object
+      form, that is based on (or derived from) the Work and for which the
+      editorial revisions, annotations, elaborations, or other modifications
+      represent, as a whole, an original work of authorship. For the purposes
+      of this License, Derivative Works shall not include works that remain
+      separable from, or merely link (or bind by name) to the interfaces of,
+      the Work and Derivative Works thereof.
+
+      "Contribution" shall mean any work of authorship, including
+      the original version of the Work and any modifications or additions
+      to that Work or Derivative Works thereof, that is intentionally
+      submitted to Licensor for inclusion in the Work by the copyright owner
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+      to the Licensor or its representatives, including but not limited to
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+
+      "Contributor" shall mean Licensor and any individual or Legal Entity
+      on behalf of whom a Contribution has been received by Licensor and
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+
+   2. Grant of Copyright License. Subject to the terms and conditions of
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+      copyright license to reproduce, prepare Derivative Works of,
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+      (c) You must retain, in the Source form of any Derivative Works
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+      You may add Your own copyright statement to Your modifications and
+      may provide additional or different license terms and conditions
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+      reproduction, and distribution of the Work otherwise complies with
+      the conditions stated in this License.
+
+   5. Submission of Contributions. Unless You explicitly state otherwise,
+      any Contribution intentionally submitted for inclusion in the Work
+      by You to the Licensor shall be under the terms and conditions of
+      this License, without any additional terms or conditions.
+      Notwithstanding the above, nothing herein shall supersede or modify
+      the terms of any separate license agreement you may have executed
+      with Licensor regarding such Contributions.
+
+   6. Trademarks. This License does not grant permission to use the trade
+      names, trademarks, service marks, or product names of the Licensor,
+      except as required for reasonable and customary use in describing the
+      origin of the Work and reproducing the content of the NOTICE file.
+
+   7. Disclaimer of Warranty. Unless required by applicable law or
+      agreed to in writing, Licensor provides the Work (and each
+      Contributor provides its Contributions) on an "AS IS" BASIS,
+      WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or
+      implied, including, without limitation, any warranties or conditions
+      of TITLE, NON-INFRINGEMENT, MERCHANTABILITY, or FITNESS FOR A
+      PARTICULAR PURPOSE. You are solely responsible for determining the
+      appropriateness of using or redistributing the Work and assume any
+      risks associated with Your exercise of permissions under this License.
+
+   8. Limitation of Liability. In no event and under no legal theory,
+      whether in tort (including negligence), contract, or otherwise,
+      unless required by applicable law (such as deliberate and grossly
+      negligent acts) or agreed to in writing, shall any Contributor be
+      liable to You for damages, including any direct, indirect, special,
+      incidental, or consequential damages of any character arising as a
+      result of this License or out of the use or inability to use the
+      Work (including but not limited to damages for loss of goodwill,
+      work stoppage, computer failure or malfunction, or any and all
+      other commercial damages or losses), even if such Contributor
+      has been advised of the possibility of such damages.
+
+   9. Accepting Warranty or Additional Liability. While redistributing
+      the Work or Derivative Works thereof, You may choose to offer,
+      and charge a fee for, acceptance of support, warranty, indemnity,
+      or other liability obligations and/or rights consistent with this
+      License. However, in accepting such obligations, You may act only
+      on Your own behalf and on Your sole responsibility, not on behalf
+      of any other Contributor, and only if You agree to indemnify,
+      defend, and hold each Contributor harmless for any liability
+      incurred by, or claims asserted against, such Contributor by reason
+      of your accepting any such warranty or additional liability.
+
+   END OF TERMS AND CONDITIONS
+
+   APPENDIX: How to apply the Apache License to your work.
+
+      To apply the Apache License to your work, attach the following
+      boilerplate notice, with the fields enclosed by brackets "[]"
+      replaced with your own identifying information. (Don't include
+      the brackets!)  The text should be enclosed in the appropriate
+      comment syntax for the file format. We also recommend that a
+      file or class name and description of purpose be included on the
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+
+   Copyright The OpenTelemetry Authors
+
+   Licensed under the Apache License, Version 2.0 (the "License");
+   you may not use this file except in compliance with the License.
+   You may obtain a copy of the License at
+
+       http://www.apache.org/licenses/LICENSE-2.0
+
+   Unless required by applicable law or agreed to in writing, software
+   distributed under the License is distributed on an "AS IS" BASIS,
+   WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+   See the License for the specific language governing permissions and
+   limitations under the License.
diff --git a/instrumentation/httpx/README.md b/instrumentation/httpx/README.md
new file mode 100644
index 000000000..2053e8ab1
--- /dev/null
+++ b/instrumentation/httpx/README.md
@@ -0,0 +1,49 @@
+# OpenTelemetry Http Instrumentation
+
+The HTTPX instrumentation is a community-maintained instrumentation for the [HTTPX][httpx-home] gem.
+
+## How do I get started?
+
+Install the gem using:
+
+```
+gem install opentelemetry-instrumentation-httpx
+```
+
+Or, if you use [bundler][bundler-home], include `opentelemetry-instrumentation-httpx` in your `Gemfile`.
+
+## Usage
+
+To use the instrumentation, call `use` with the name of the instrumentation:
+
+```ruby
+OpenTelemetry::SDK.configure do |c|
+  c.use 'OpenTelemetry::Instrumentation::HTTPX'
+end
+```
+
+Alternatively, you can also call `use_all` to install all the available instrumentation.
+
+```ruby
+OpenTelemetry::SDK.configure do |c|
+  c.use_all
+end
+```
+
+## How can I get involved?
+
+The `opentelemetry-instrumentation-httpx` gem source is [on github][repo-github], along with related gems including `opentelemetry-api` and `opentelemetry-sdk`.
+
+The OpenTelemetry Ruby gems are maintained by the OpenTelemetry-Ruby special interest group (SIG). You can get involved by joining us in [GitHub Discussions][discussions-url] or attending our weekly meeting. See the [meeting calendar][community-meetings] for dates and times. For more information on this and other language SIGs, see the OpenTelemetry [community page][ruby-sig].
+
+## License
+
+The `opentelemetry-instrumentation-httpx` gem is distributed under the Apache 2.0 license. See [LICENSE][license-github] for more information.
+
+[http-home]: https://gitlab.com/os85/httpx
+[bundler-home]: https://bundler.io
+[repo-github]: https://github.com/open-telemetry/opentelemetry-ruby
+[license-github]: https://github.com/open-telemetry/opentelemetry-ruby-contrib/blob/main/LICENSE
+[ruby-sig]: https://github.com/open-telemetry/community#ruby-sig
+[community-meetings]: https://github.com/open-telemetry/community#community-meetings
+[discussions-url]: https://github.com/open-telemetry/opentelemetry-ruby/discussions
diff --git a/instrumentation/httpx/Rakefile b/instrumentation/httpx/Rakefile
new file mode 100644
index 000000000..1a64ba842
--- /dev/null
+++ b/instrumentation/httpx/Rakefile
@@ -0,0 +1,28 @@
+# frozen_string_literal: true
+
+# Copyright The OpenTelemetry Authors
+#
+# SPDX-License-Identifier: Apache-2.0
+
+require 'bundler/gem_tasks'
+require 'rake/testtask'
+require 'yard'
+require 'rubocop/rake_task'
+
+RuboCop::RakeTask.new
+
+Rake::TestTask.new :test do |t|
+  t.libs << 'test'
+  t.libs << 'lib'
+  t.test_files = FileList['test/**/*_test.rb']
+end
+
+YARD::Rake::YardocTask.new do |t|
+  t.stats_options = ['--list-undoc']
+end
+
+if RUBY_ENGINE == 'truffleruby'
+  task default: %i[test]
+else
+  task default: %i[test rubocop yard]
+end
diff --git a/instrumentation/httpx/example/trace_demonstration.rb b/instrumentation/httpx/example/trace_demonstration.rb
new file mode 100644
index 000000000..f0afdbf11
--- /dev/null
+++ b/instrumentation/httpx/example/trace_demonstration.rb
@@ -0,0 +1,27 @@
+# frozen_string_literal: true
+
+require 'bundler/inline'
+
+gemfile(true) do
+  source 'https://rubygems.org'
+  gem 'opentelemetry-api'
+  gem 'opentelemetry-instrumentation-base'
+  gem 'opentelemetry-instrumentation-httpx'
+  gem 'opentelemetry-sdk'
+  gem 'httpx'
+end
+
+require 'opentelemetry-api'
+require 'opentelemetry-sdk'
+require 'opentelemetry-instrumentation-httpx'
+require 'httpx'
+
+# Export traces to console by default
+ENV['OTEL_TRACES_EXPORTER'] ||= 'console'
+
+OpenTelemetry::SDK.configure do |c|
+  c.use 'OpenTelemetry::Instrumentation::HTTPX'
+end
+
+# A basic HTTP example
+HTTPX.get('https://github.com')
diff --git a/instrumentation/httpx/lib/opentelemetry-instrumentation-httpx.rb b/instrumentation/httpx/lib/opentelemetry-instrumentation-httpx.rb
new file mode 100644
index 000000000..c034f140f
--- /dev/null
+++ b/instrumentation/httpx/lib/opentelemetry-instrumentation-httpx.rb
@@ -0,0 +1,7 @@
+# frozen_string_literal: true
+
+# Copyright The OpenTelemetry Authors
+#
+# SPDX-License-Identifier: Apache-2.0
+
+require_relative 'opentelemetry/instrumentation'
diff --git a/instrumentation/httpx/lib/opentelemetry/instrumentation.rb b/instrumentation/httpx/lib/opentelemetry/instrumentation.rb
new file mode 100644
index 000000000..b9459a853
--- /dev/null
+++ b/instrumentation/httpx/lib/opentelemetry/instrumentation.rb
@@ -0,0 +1,19 @@
+# frozen_string_literal: true
+
+# Copyright The OpenTelemetry Authors
+#
+# SPDX-License-Identifier: Apache-2.0
+
+# OpenTelemetry is an open source observability framework, providing a
+# general-purpose API, SDK, and related tools required for the instrumentation
+# of cloud-native software, frameworks, and libraries.
+#
+# The OpenTelemetry module provides global accessors for telemetry objects.
+# See the documentation for the `opentelemetry-api` gem for details.
+module OpenTelemetry
+  # Instrumentation should be able to handle the case when the library is not installed on a user's system.
+  module Instrumentation
+  end
+end
+
+require_relative 'instrumentation/httpx'
diff --git a/instrumentation/httpx/lib/opentelemetry/instrumentation/httpx.rb b/instrumentation/httpx/lib/opentelemetry/instrumentation/httpx.rb
new file mode 100644
index 000000000..70e00f6cc
--- /dev/null
+++ b/instrumentation/httpx/lib/opentelemetry/instrumentation/httpx.rb
@@ -0,0 +1,19 @@
+# frozen_string_literal: true
+
+# Copyright The OpenTelemetry Authors
+#
+# SPDX-License-Identifier: Apache-2.0
+
+require 'opentelemetry'
+require 'opentelemetry-instrumentation-base'
+
+module OpenTelemetry
+  module Instrumentation
+    # Contains the OpenTelemetry instrumentation for the Http gem
+    module HTTPX
+    end
+  end
+end
+
+require_relative 'httpx/instrumentation'
+require_relative 'httpx/version'
diff --git a/instrumentation/httpx/lib/opentelemetry/instrumentation/httpx/instrumentation.rb b/instrumentation/httpx/lib/opentelemetry/instrumentation/httpx/instrumentation.rb
new file mode 100644
index 000000000..9174343b4
--- /dev/null
+++ b/instrumentation/httpx/lib/opentelemetry/instrumentation/httpx/instrumentation.rb
@@ -0,0 +1,40 @@
+# frozen_string_literal: true
+
+# Copyright The OpenTelemetry Authors
+#
+# SPDX-License-Identifier: Apache-2.0
+
+module OpenTelemetry
+  module Instrumentation
+    module HTTPX
+      # The Instrumentation class contains logic to detect and install the Http instrumentation
+      class Instrumentation < OpenTelemetry::Instrumentation::Base
+        install do |_config|
+          require_dependencies
+          patch
+        end
+
+        compatible do
+          Gem::Version.new(::HTTPX::VERSION) >= Gem::Version.new('0.24.7')
+        end
+
+        present do
+          defined?(::HTTPX)
+        end
+
+        option :peer_service, default: nil, validate: :string
+
+        def patch
+          otel_session = ::HTTPX.plugin(Plugin)
+
+          ::HTTPX.send(:remove_const, :Session)
+          ::HTTPX.send(:const_set, :Session, otel_session.class)
+        end
+
+        def require_dependencies
+          require_relative 'plugin'
+        end
+      end
+    end
+  end
+end
diff --git a/instrumentation/httpx/lib/opentelemetry/instrumentation/httpx/plugin.rb b/instrumentation/httpx/lib/opentelemetry/instrumentation/httpx/plugin.rb
new file mode 100644
index 000000000..10738e1ed
--- /dev/null
+++ b/instrumentation/httpx/lib/opentelemetry/instrumentation/httpx/plugin.rb
@@ -0,0 +1,92 @@
+# frozen_string_literal: true
+
+# Copyright The OpenTelemetry Authors
+#
+# SPDX-License-Identifier: Apache-2.0
+
+module OpenTelemetry
+  module Instrumentation
+    module HTTPX
+      module Plugin
+        # Instruments around HTTPX's request/response lifecycle in order to generate
+        # an OTEL trace.
+        class RequestTracer
+          def initialize(request)
+            @request = request
+          end
+
+          def call
+            @request.on(:response, &method(:finish))
+
+            uri = @request.uri
+            request_method = @request.verb
+            span_name = "HTTP #{request_method}"
+
+            attributes = {
+              OpenTelemetry::SemanticConventions::Trace::HTTP_HOST => uri.host,
+              OpenTelemetry::SemanticConventions::Trace::HTTP_METHOD => request_method,
+              OpenTelemetry::SemanticConventions::Trace::HTTP_SCHEME => uri.scheme,
+              OpenTelemetry::SemanticConventions::Trace::HTTP_TARGET => uri.path,
+              OpenTelemetry::SemanticConventions::Trace::HTTP_URL => "#{uri.scheme}://#{uri.host}",
+              OpenTelemetry::SemanticConventions::Trace::NET_PEER_NAME => uri.host,
+              OpenTelemetry::SemanticConventions::Trace::NET_PEER_PORT => uri.port
+            }
+            config = HTTPX::Instrumentation.instance.config
+            attributes[OpenTelemetry::SemanticConventions::Trace::PEER_SERVICE] = config[:peer_service] if config[:peer_service]
+            attributes.merge!(
+              OpenTelemetry::Common::HTTP::ClientContext.attributes
+            )
+
+            @span = tracer.start_span(span_name, attributes: attributes, kind: :client)
+            trace_ctx = OpenTelemetry::Trace.context_with_span(@span)
+            @trace_token = OpenTelemetry::Context.attach(trace_ctx)
+
+            OpenTelemetry.propagation.inject(@request.headers)
+          rescue StandardError => e
+            OpenTelemetry.handle_error(exception: e)
+          end
+
+          def finish(response)
+            return unless @span
+
+            if response.is_a?(::HTTPX::ErrorResponse)
+              @span.record_exception(response.error)
+              @span.status = Trace::Status.error("Unhandled exception of type: #{response.error.class}")
+            else
+              @span.set_attribute(OpenTelemetry::SemanticConventions::Trace::HTTP_STATUS_CODE, response.status)
+              @span.status = Trace::Status.error unless (100..399).include?(response.status)
+            end
+
+            OpenTelemetry::Context.detach(@trace_token) if @trace_token
+            @span.finish
+          end
+
+          private
+
+          def tracer
+            HTTPX::Instrumentation.instance.tracer
+          end
+        end
+
+        # HTTPX::Request overrides
+        module RequestMethods
+          def __otel_enable_trace!
+            return if @__otel_enable_trace
+
+            RequestTracer.new(self).call
+            @__otel_enable_trace = true
+          end
+        end
+
+        # HTTPX::Connection overrides
+        module ConnectionMethods
+          def send(request)
+            request.__otel_enable_trace!
+
+            super
+          end
+        end
+      end
+    end
+  end
+end
diff --git a/instrumentation/httpx/lib/opentelemetry/instrumentation/httpx/version.rb b/instrumentation/httpx/lib/opentelemetry/instrumentation/httpx/version.rb
new file mode 100644
index 000000000..b05472d1e
--- /dev/null
+++ b/instrumentation/httpx/lib/opentelemetry/instrumentation/httpx/version.rb
@@ -0,0 +1,13 @@
+# frozen_string_literal: true
+
+# Copyright The OpenTelemetry Authors
+#
+# SPDX-License-Identifier: Apache-2.0
+
+module OpenTelemetry
+  module Instrumentation
+    module HTTPX
+      VERSION = '0.1.0'
+    end
+  end
+end
diff --git a/instrumentation/httpx/opentelemetry-instrumentation-httpx.gemspec b/instrumentation/httpx/opentelemetry-instrumentation-httpx.gemspec
new file mode 100644
index 000000000..6531619a7
--- /dev/null
+++ b/instrumentation/httpx/opentelemetry-instrumentation-httpx.gemspec
@@ -0,0 +1,50 @@
+# frozen_string_literal: true
+
+# Copyright The OpenTelemetry Authors
+#
+# SPDX-License-Identifier: Apache-2.0
+
+lib = File.expand_path('lib', __dir__)
+$LOAD_PATH.unshift(lib) unless $LOAD_PATH.include?(lib)
+require 'opentelemetry/instrumentation/httpx/version'
+
+Gem::Specification.new do |spec|
+  spec.name        = 'opentelemetry-instrumentation-httpx'
+  spec.version     = OpenTelemetry::Instrumentation::HTTPX::VERSION
+  spec.authors     = ['OpenTelemetry Authors']
+  spec.email       = ['cncf-opentelemetry-contributors@lists.cncf.io']
+
+  spec.summary     = 'HTTPX instrumentation for the OpenTelemetry framework'
+  spec.description = 'HTTPX instrumentation for the OpenTelemetry framework'
+  spec.homepage    = 'https://github.com/open-telemetry/opentelemetry-ruby-contrib'
+  spec.license     = 'Apache-2.0'
+
+  spec.files = Dir.glob('lib/**/*.rb') +
+               Dir.glob('*.md') +
+               ['LICENSE', '.yardopts']
+  spec.require_paths = ['lib']
+  spec.required_ruby_version = '>= 3.0'
+
+  spec.add_dependency 'opentelemetry-api', '~> 1.0'
+  spec.add_dependency 'opentelemetry-instrumentation-base', '~> 0.22.1'
+
+  spec.add_development_dependency 'appraisal', '~> 2.5'
+  spec.add_development_dependency 'bundler', '~> 2.4'
+  spec.add_development_dependency 'httpx'
+  spec.add_development_dependency 'minitest', '~> 5.0'
+  spec.add_development_dependency 'opentelemetry-sdk', '~> 1.1'
+  spec.add_development_dependency 'opentelemetry-test-helpers', '~> 0.3'
+  spec.add_development_dependency 'rake', '~> 13.0'
+  spec.add_development_dependency 'rspec-mocks'
+  spec.add_development_dependency 'rubocop', '~> 1.56.1'
+  spec.add_development_dependency 'simplecov', '~> 0.17.1'
+  spec.add_development_dependency 'webmock', '~> 3.19'
+  spec.add_development_dependency 'yard', '~> 0.9'
+
+  if spec.respond_to?(:metadata)
+    spec.metadata['changelog_uri'] = "https://rubydoc.info/gems/#{spec.name}/#{spec.version}/file/CHANGELOG.md"
+    spec.metadata['source_code_uri'] = 'https://github.com/open-telemetry/opentelemetry-ruby-contrib/tree/main/instrumentation/http'
+    spec.metadata['bug_tracker_uri'] = 'https://github.com/open-telemetry/opentelemetry-ruby-contrib/issues'
+    spec.metadata['documentation_uri'] = "https://rubydoc.info/gems/#{spec.name}/#{spec.version}"
+  end
+end
diff --git a/instrumentation/httpx/test/instrumentation/httpx/instrumentation_test.rb b/instrumentation/httpx/test/instrumentation/httpx/instrumentation_test.rb
new file mode 100644
index 000000000..70dda9013
--- /dev/null
+++ b/instrumentation/httpx/test/instrumentation/httpx/instrumentation_test.rb
@@ -0,0 +1,28 @@
+# frozen_string_literal: true
+
+# Copyright The OpenTelemetry Authors
+#
+# SPDX-License-Identifier: Apache-2.0
+
+require 'test_helper'
+
+require_relative '../../../lib/opentelemetry/instrumentation/httpx'
+
+describe OpenTelemetry::Instrumentation::HTTPX do
+  let(:instrumentation) { OpenTelemetry::Instrumentation::HTTPX::Instrumentation.instance }
+
+  it 'has #name' do
+    _(instrumentation.name).must_equal 'OpenTelemetry::Instrumentation::HTTPX'
+  end
+
+  it 'has #version' do
+    _(instrumentation.version).wont_be_nil
+    _(instrumentation.version).wont_be_empty
+  end
+
+  describe '#install' do
+    it 'accepts argument' do
+      _(instrumentation.install({})).must_equal(true)
+    end
+  end
+end
diff --git a/instrumentation/httpx/test/instrumentation/plugin_test.rb b/instrumentation/httpx/test/instrumentation/plugin_test.rb
new file mode 100644
index 000000000..585e8f50f
--- /dev/null
+++ b/instrumentation/httpx/test/instrumentation/plugin_test.rb
@@ -0,0 +1,139 @@
+# frozen_string_literal: true
+
+# Copyright The OpenTelemetry Authors
+#
+# SPDX-License-Identifier: Apache-2.0
+
+require 'test_helper'
+
+require_relative '../../lib/opentelemetry/instrumentation/httpx'
+require_relative '../../lib/opentelemetry/instrumentation/httpx/plugin'
+
+describe OpenTelemetry::Instrumentation::HTTPX::Plugin do
+  let(:instrumentation) { OpenTelemetry::Instrumentation::HTTPX::Instrumentation.instance }
+  let(:exporter) { EXPORTER }
+  let(:span) { exporter.finished_spans.first }
+
+  before do
+    exporter.reset
+    stub_request(:get, 'http://example.com/success').to_return(status: 200)
+    stub_request(:get, 'http://example.com/failure').to_return(status: 500)
+    stub_request(:get, 'http://example.com/timeout').to_timeout
+  end
+
+  # Force re-install of instrumentation
+  after { instrumentation.instance_variable_set(:@installed, false) }
+
+  describe 'tracing' do
+    before do
+      instrumentation.install
+    end
+
+    it 'before request' do
+      _(exporter.finished_spans.size).must_equal 0
+    end
+
+    it 'after request with success code' do
+      HTTPX.get('http://example.com/success')
+
+      _(exporter.finished_spans.size).must_equal 1
+      _(span.name).must_equal 'HTTP GET'
+      _(span.attributes['http.method']).must_equal 'GET'
+      _(span.attributes['http.status_code']).must_equal 200
+      _(span.attributes['http.scheme']).must_equal 'http'
+      _(span.attributes['http.host']).must_equal 'example.com'
+      _(span.attributes['http.target']).must_equal '/success'
+      assert_requested(
+        :get,
+        'http://example.com/success',
+        headers: { 'Traceparent' => "00-#{span.hex_trace_id}-#{span.hex_span_id}-01" }
+      )
+    end
+
+    it 'after request with failure code' do
+      HTTPX.get('http://example.com/failure')
+
+      _(exporter.finished_spans.size).must_equal 1
+      _(span.name).must_equal 'HTTP GET'
+      _(span.attributes['http.method']).must_equal 'GET'
+      _(span.attributes['http.status_code']).must_equal 500
+      _(span.attributes['http.scheme']).must_equal 'http'
+      _(span.attributes['http.host']).must_equal 'example.com'
+      _(span.attributes['http.target']).must_equal '/failure'
+      assert_requested(
+        :get,
+        'http://example.com/failure',
+        headers: { 'Traceparent' => "00-#{span.hex_trace_id}-#{span.hex_span_id}-01" }
+      )
+    end
+
+    it 'after request timeout' do
+      response = HTTPX.get('http://example.com/timeout')
+      assert response.is_a?(HTTPX::ErrorResponse)
+      assert response.error.is_a?(HTTPX::TimeoutError)
+
+      _(exporter.finished_spans.size).must_equal 1
+      _(span.name).must_equal 'HTTP GET'
+      _(span.attributes['http.method']).must_equal 'GET'
+      _(span.attributes['http.scheme']).must_equal 'http'
+      _(span.attributes['http.host']).must_equal 'example.com'
+      _(span.attributes['http.target']).must_equal '/timeout'
+      _(span.status.code).must_equal(
+        OpenTelemetry::Trace::Status::ERROR
+      )
+      _(span.status.description).must_equal(
+        'Unhandled exception of type: HTTPX::TimeoutError'
+      )
+      assert_requested(
+        :get,
+        'http://example.com/timeout',
+        headers: { 'Traceparent' => "00-#{span.hex_trace_id}-#{span.hex_span_id}-01" }
+      )
+    end
+
+    it 'merges HTTP client context' do
+      client_context_attrs = {
+        'test.attribute' => 'test.value', 'http.method' => 'OVERRIDE'
+      }
+
+      OpenTelemetry::Common::HTTP::ClientContext.with_attributes(client_context_attrs) do
+        HTTPX.get('http://example.com/success')
+      end
+
+      _(exporter.finished_spans.size).must_equal 1
+      _(span.name).must_equal 'HTTP GET'
+      _(span.attributes['http.method']).must_equal 'OVERRIDE'
+      _(span.attributes['http.status_code']).must_equal 200
+      _(span.attributes['http.scheme']).must_equal 'http'
+      _(span.attributes['http.host']).must_equal 'example.com'
+      _(span.attributes['http.target']).must_equal '/success'
+      _(span.attributes['test.attribute']).must_equal 'test.value'
+      assert_requested(
+        :get,
+        'http://example.com/success',
+        headers: { 'Traceparent' => "00-#{span.hex_trace_id}-#{span.hex_span_id}-01" }
+      )
+    end
+
+    it 'accepts peer service name from config' do
+      instrumentation.instance_variable_set(:@installed, false)
+      instrumentation.install(peer_service: 'example:httpx')
+
+      HTTPX.get('http://example.com/success')
+
+      _(span.attributes['peer.service']).must_equal 'example:httpx'
+    end
+
+    it 'prioritizes context attributes over config for peer service name' do
+      instrumentation.instance_variable_set(:@installed, false)
+      instrumentation.install(peer_service: 'example:static')
+
+      client_context_attrs = { 'peer.service' => 'example:custom' }
+      OpenTelemetry::Common::HTTP::ClientContext.with_attributes(client_context_attrs) do
+        HTTPX.get('http://example.com/success')
+      end
+
+      _(span.attributes['peer.service']).must_equal 'example:custom'
+    end
+  end
+end
diff --git a/instrumentation/httpx/test/test_helper.rb b/instrumentation/httpx/test/test_helper.rb
new file mode 100644
index 000000000..10c09f2da
--- /dev/null
+++ b/instrumentation/httpx/test/test_helper.rb
@@ -0,0 +1,22 @@
+# frozen_string_literal: true
+
+# Copyright The OpenTelemetry Authors
+#
+# SPDX-License-Identifier: Apache-2.0
+
+require 'bundler/setup'
+Bundler.require(:default, :development, :test)
+
+require 'minitest/autorun'
+require 'httpx/adapters/webmock'
+require 'webmock/minitest'
+
+# global opentelemetry-sdk setup:
+EXPORTER = OpenTelemetry::SDK::Trace::Export::InMemorySpanExporter.new
+span_processor = OpenTelemetry::SDK::Trace::Export::SimpleSpanProcessor.new(EXPORTER)
+
+OpenTelemetry::SDK.configure do |c|
+  c.error_handler = ->(exception:, message:) { raise(exception || message) }
+  c.logger = Logger.new($stderr, level: ENV.fetch('OTEL_LOG_LEVEL', 'fatal').to_sym)
+  c.add_span_processor span_processor
+end