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After doing this the 2D depiction didn't show the color change on the molecule anymore, I think this has something to do with the match being for the origin molecule instead of the copy.
I don't think this is serious right now because all of these scripts are targeted at depicting molecules so we're not trying to access the 3D coordinates after depicting it.
@cbayly13 pointed out an internal issue with oedepict today. When it is used to depict a molecule it flattens it. So the coordinates are lost.
This is used in a few places in this repository:
SmartsDepict.py
substructRemove.py
smiAmberize.py
oebHasAmberParams.py
oebToAmberMol2TopCrd.py
smartsDepict.ipynb
substrucDepict.ipynb
Instead a copy of the molecule should be used for the depiction, for example:
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