diff --git a/example_files/example.annotation b/example_files/example.annotation new file mode 100644 index 0000000..47fc40e --- /dev/null +++ b/example_files/example.annotation @@ -0,0 +1,123 @@ +## ENSEMBL VARIANT EFFECT PREDICTOR v108.1 +## Output produced at 2022-11-13 22:57:45 +## Using cache in ./homo_sapiens/105_GRCh37 +## Using API version 108, DB version ? +## ensembl-variation version 108.a885ada +## ensembl version 108.d8a9c80 +## ensembl-io version 108.58d13c1 +## ensembl-funcgen version 108.56bb136 +## gnomAD version r2.1 +## dbSNP version 154 +## COSMIC version 92 +## ClinVar version 202012 +## polyphen version 2.2.2 +## sift version sift5.2.2 +## genebuild version 2011-04 +## HGMD-PUBLIC version 20204 +## 1000genomes version phase3 +## assembly version GRCh37.p13 +## regbuild version 1.0 +## gencode version GENCODE 19 +## Column descriptions: +## Uploaded_variation : Identifier of uploaded variant +## Location : Location of variant in standard coordinate format (chr:start or chr:start-end) +## Allele : The variant allele used to calculate the consequence +## Gene : Stable ID of affected gene +## Feature : Stable ID of feature +## Feature_type : Type of feature - Transcript, RegulatoryFeature or MotifFeature +## Consequence : Consequence type +## cDNA_position : Relative position of base pair in cDNA sequence +## CDS_position : Relative position of base pair in coding sequence +## Protein_position : Relative position of amino acid in protein +## Amino_acids : Reference and variant amino acids +## Codons : Reference and variant codon sequence +## Existing_variation : Identifier(s) of co-located known variants +## Extra column keys: +## IMPACT : Subjective impact classification of consequence type +## DISTANCE : Shortest distance from variant to transcript +## STRAND : Strand of the feature (1/-1) +## FLAGS : Transcript quality flags +## BIOTYPE : Biotype of transcript or regulatory feature +## NEAREST : Identifier(s) of nearest transcription start site +## VEP command-line: vep --offline --cache --dir_cache . -i HARE_results/example.snps -o HARE_results/example.annotation --nearest gene --cache_version 105 --distance 5000 --biotype --force_overwrite +#Uploaded_variation Location Allele Gene Feature Feature_type Consequence cDNA_position CDS_position Protein_position Amino_acids Codons Existing_variation Extra +rs4908936 1:5963669 C ENSG00000131697 ENST00000378156 Transcript intron_variant - - - - - - IMPACT=MODIFIER;STRAND=-1;BIOTYPE=protein_coding;NEAREST=ENSG00000069424 +rs4908936 1:5963669 C ENSG00000131697 ENST00000378169 Transcript intron_variant,NMD_transcript_variant - - - - - - IMPACT=MODIFIER;STRAND=-1;BIOTYPE=nonsense_mediated_decay;NEAREST=ENSG00000069424 +rs4908936 1:5963669 C ENSG00000131697 ENST00000466897 Transcript intron_variant,NMD_transcript_variant - - - - - - IMPACT=MODIFIER;STRAND=-1;FLAGS=cds_start_NF;BIOTYPE=nonsense_mediated_decay;NEAREST=ENSG00000069424 +rs4908936 1:5963669 C ENSG00000131697 ENST00000478423 Transcript intron_variant,non_coding_transcript_variant - - - - - - IMPACT=MODIFIER;STRAND=-1;BIOTYPE=processed_transcript;NEAREST=ENSG00000069424 +rs4908936 1:5963669 C ENSG00000131697 ENST00000489180 Transcript intron_variant,NMD_transcript_variant - - - - - - IMPACT=MODIFIER;STRAND=-1;BIOTYPE=nonsense_mediated_decay;NEAREST=ENSG00000069424 +rs4411131 1:116164626 C ENSG00000207502 ENST00000384771 Transcript non_coding_transcript_exon_variant 1 - - - - - IMPACT=MODIFIER;STRAND=-1;BIOTYPE=snoRNA;NEAREST=ENSG00000173218 +rs10800714 1:200562117 A ENSG00000118193 ENST00000367350 Transcript intron_variant - - - - - - IMPACT=MODIFIER;STRAND=-1;BIOTYPE=protein_coding;NEAREST=ENSG00000118193 +rs189606623 3:46432609 C ENSG00000223552 ENST00000451485 Transcript intron_variant,non_coding_transcript_variant - - - - - - IMPACT=MODIFIER;STRAND=-1;BIOTYPE=antisense;NEAREST=ENSG00000121797 +rs6548981 3:68148825 T ENSG00000183662 ENST00000478136 Transcript intron_variant - - - - - - IMPACT=MODIFIER;STRAND=1;BIOTYPE=protein_coding;NEAREST=ENSG00000183662 +rs6548981 3:68148825 T ENSG00000183662 ENST00000496687 Transcript intron_variant - - - - - - IMPACT=MODIFIER;STRAND=1;BIOTYPE=protein_coding;NEAREST=ENSG00000183662 +rs4600819 3:163285923 A - - - intergenic_variant - - - - - - IMPACT=MODIFIER;NEAREST=ENSG00000090402 +rs74505207 4:759883 A ENSG00000185619 ENST00000362003 Transcript 3_prime_UTR_variant 1140 - - - - - IMPACT=MODIFIER;STRAND=1;BIOTYPE=protein_coding;NEAREST=ENSG00000185619 +rs74505207 4:759883 A ENSG00000185619 ENST00000430644 Transcript 3_prime_UTR_variant,NMD_transcript_variant 2117 - - - - - IMPACT=MODIFIER;STRAND=1;BIOTYPE=nonsense_mediated_decay;NEAREST=ENSG00000185619 +rs74505207 4:759883 A ENSG00000185619 ENST00000440452 Transcript 3_prime_UTR_variant,NMD_transcript_variant 2108 - - - - - IMPACT=MODIFIER;STRAND=1;BIOTYPE=nonsense_mediated_decay;NEAREST=ENSG00000185619 +rs74505207 4:759883 A ENSG00000233799 ENST00000454037 Transcript upstream_gene_variant - - - - - - IMPACT=MODIFIER;DISTANCE=1021;STRAND=-1;BIOTYPE=antisense;NEAREST=ENSG00000185619 +rs74505207 4:759883 A ENSG00000185619 ENST00000470161 Transcript 3_prime_UTR_variant 1139 - - - - - IMPACT=MODIFIER;STRAND=1;BIOTYPE=protein_coding;NEAREST=ENSG00000185619 +rs74505207 4:759883 A ENSG00000185619 ENST00000488032 Transcript downstream_gene_variant - - - - - - IMPACT=MODIFIER;DISTANCE=4731;STRAND=1;BIOTYPE=processed_transcript;NEAREST=ENSG00000185619 +rs74505207 4:759883 A ENSG00000249592 ENST00000503571 Transcript intron_variant,non_coding_transcript_variant - - - - - - IMPACT=MODIFIER;STRAND=-1;BIOTYPE=antisense;NEAREST=ENSG00000185619 +rs74505207 4:759883 A ENSG00000185619 ENST00000505655 Transcript 3_prime_UTR_variant 789 - - - - - IMPACT=MODIFIER;STRAND=1;BIOTYPE=protein_coding;NEAREST=ENSG00000185619 +rs74505207 4:759883 A ENSG00000249592 ENST00000507446 Transcript downstream_gene_variant - - - - - - IMPACT=MODIFIER;DISTANCE=1046;STRAND=-1;BIOTYPE=antisense;NEAREST=ENSG00000185619 +rs74505207 4:759883 A ENSG00000185619 ENST00000521023 Transcript 3_prime_UTR_variant 2108 - - - - - IMPACT=MODIFIER;STRAND=1;BIOTYPE=protein_coding;NEAREST=ENSG00000185619 +rs374109 5:10012518 G - - - intergenic_variant - - - - - - IMPACT=MODIFIER;NEAREST=ENSG00000150756 +rs6892991 5:25609505 G - - - intergenic_variant - - - - - - IMPACT=MODIFIER;NEAREST=ENSG00000040731 +rs356561 5:63328721 C - - - intergenic_variant - - - - - - IMPACT=MODIFIER;NEAREST=ENSG00000178394 +rs10037878 5:100529927 A - - - intergenic_variant - - - - - - IMPACT=MODIFIER;NEAREST=ENSG00000113532 +rs35765330 5:128579817 C - - - intergenic_variant - - - - - - IMPACT=MODIFIER;NEAREST=ENSG00000066583 +rs114006078 6:31211473 A - - - intergenic_variant - - - - - - IMPACT=MODIFIER;NEAREST=ENSG00000204525 +rs2931085 6:120662994 C - - - intergenic_variant - - - - - - IMPACT=MODIFIER;NEAREST=ENSG00000111885 +rs17867623 7:89979275 A ENSG00000105793 ENST00000222511 Transcript intron_variant - - - - - - IMPACT=MODIFIER;STRAND=1;BIOTYPE=protein_coding;NEAREST=ENSG00000105793 +rs17867623 7:89979275 A ENSG00000105793 ENST00000257659 Transcript intron_variant - - - - - - IMPACT=MODIFIER;STRAND=1;BIOTYPE=protein_coding;NEAREST=ENSG00000105793 +rs17867623 7:89979275 A ENSG00000105793 ENST00000380058 Transcript intron_variant,NMD_transcript_variant - - - - - - IMPACT=MODIFIER;STRAND=1;BIOTYPE=nonsense_mediated_decay;NEAREST=ENSG00000105793 +rs17867623 7:89979275 A ENSG00000105793 ENST00000417207 Transcript intron_variant - - - - - - IMPACT=MODIFIER;STRAND=1;FLAGS=cds_end_NF;BIOTYPE=protein_coding;NEAREST=ENSG00000105793 +rs17867623 7:89979275 A ENSG00000105793 ENST00000421719 Transcript intron_variant,NMD_transcript_variant - - - - - - IMPACT=MODIFIER;STRAND=1;BIOTYPE=nonsense_mediated_decay;NEAREST=ENSG00000105793 +rs17867623 7:89979275 A ENSG00000105793 ENST00000426366 Transcript intron_variant - - - - - - IMPACT=MODIFIER;STRAND=1;FLAGS=cds_end_NF;BIOTYPE=protein_coding;NEAREST=ENSG00000105793 +rs17867623 7:89979275 A ENSG00000105793 ENST00000439832 Transcript intron_variant,NMD_transcript_variant - - - - - - IMPACT=MODIFIER;STRAND=1;BIOTYPE=nonsense_mediated_decay;NEAREST=ENSG00000105793 +rs17867623 7:89979275 A ENSG00000105793 ENST00000450619 Transcript intron_variant - - - - - - IMPACT=MODIFIER;STRAND=1;FLAGS=cds_end_NF;BIOTYPE=protein_coding;NEAREST=ENSG00000105793 +rs17867623 7:89979275 A ENSG00000105793 ENST00000453512 Transcript intron_variant,NMD_transcript_variant - - - - - - IMPACT=MODIFIER;STRAND=1;BIOTYPE=nonsense_mediated_decay;NEAREST=ENSG00000105793 +rs17867623 7:89979275 A ENSG00000105793 ENST00000474503 Transcript upstream_gene_variant - - - - - - IMPACT=MODIFIER;DISTANCE=4567;STRAND=1;BIOTYPE=processed_transcript;NEAREST=ENSG00000105793 +rs17867623 7:89979275 A ENSG00000105793 ENST00000477972 Transcript intron_variant,non_coding_transcript_variant - - - - - - IMPACT=MODIFIER;STRAND=1;BIOTYPE=retained_intron;NEAREST=ENSG00000105793 +rs10827956 10:20365362 T ENSG00000120594 ENST00000377238 Transcript intron_variant,non_coding_transcript_variant - - - - - - IMPACT=MODIFIER;STRAND=1;BIOTYPE=processed_transcript;NEAREST=ENSG00000120594 +rs10827956 10:20365362 T ENSG00000120594 ENST00000377242 Transcript intron_variant - - - - - - IMPACT=MODIFIER;STRAND=1;BIOTYPE=protein_coding;NEAREST=ENSG00000120594 +rs10827956 10:20365362 T ENSG00000120594 ENST00000377252 Transcript intron_variant - - - - - - IMPACT=MODIFIER;STRAND=1;BIOTYPE=protein_coding;NEAREST=ENSG00000120594 +rs10827956 10:20365362 T ENSG00000238246 ENST00000451584 Transcript intron_variant,non_coding_transcript_variant - - - - - - IMPACT=MODIFIER;STRAND=-1;BIOTYPE=antisense;NEAREST=ENSG00000120594 +rs7932988 11:10094476 C ENSG00000133812 ENST00000256190 Transcript intron_variant - - - - - - IMPACT=MODIFIER;STRAND=-1;BIOTYPE=protein_coding;NEAREST=ENSG00000133812 +rs7932988 11:10094476 C ENSG00000133812 ENST00000533770 Transcript intron_variant,non_coding_transcript_variant - - - - - - IMPACT=MODIFIER;STRAND=-1;BIOTYPE=retained_intron;NEAREST=ENSG00000133812 +rs118067598 12:42810387 T ENSG00000134283 ENST00000256678 Transcript intron_variant - - - - - - IMPACT=MODIFIER;STRAND=1;BIOTYPE=protein_coding;NEAREST=ENSG00000139174 +rs118067598 12:42810387 T ENSG00000134283 ENST00000317560 Transcript intron_variant - - - - - - IMPACT=MODIFIER;STRAND=1;BIOTYPE=protein_coding;NEAREST=ENSG00000139174 +rs118067598 12:42810387 T ENSG00000134283 ENST00000337898 Transcript intron_variant - - - - - - IMPACT=MODIFIER;STRAND=1;BIOTYPE=protein_coding;NEAREST=ENSG00000139174 +rs118067598 12:42810387 T ENSG00000134283 ENST00000358314 Transcript intron_variant - - - - - - IMPACT=MODIFIER;STRAND=1;BIOTYPE=protein_coding;NEAREST=ENSG00000139174 +rs118067598 12:42810387 T ENSG00000134283 ENST00000395568 Transcript intron_variant - - - - - - IMPACT=MODIFIER;STRAND=1;BIOTYPE=protein_coding;NEAREST=ENSG00000139174 +rs118067598 12:42810387 T ENSG00000134283 ENST00000395580 Transcript intron_variant - - - - - - IMPACT=MODIFIER;STRAND=1;BIOTYPE=protein_coding;NEAREST=ENSG00000139174 +rs118067598 12:42810387 T ENSG00000134283 ENST00000432191 Transcript intron_variant - - - - - - IMPACT=MODIFIER;STRAND=1;BIOTYPE=protein_coding;NEAREST=ENSG00000139174 +rs118067598 12:42810387 T ENSG00000134283 ENST00000449194 Transcript intron_variant - - - - - - IMPACT=MODIFIER;STRAND=1;BIOTYPE=protein_coding;NEAREST=ENSG00000139174 +rs118067598 12:42810387 T ENSG00000134283 ENST00000549190 Transcript intron_variant - - - - - - IMPACT=MODIFIER;STRAND=1;BIOTYPE=protein_coding;NEAREST=ENSG00000139174 +rs118067598 12:42810387 T ENSG00000134283 ENST00000552761 Transcript intron_variant - - - - - - IMPACT=MODIFIER;STRAND=1;BIOTYPE=protein_coding;NEAREST=ENSG00000139174 +rs34193955 13:94042801 A ENSG00000183098 ENST00000377047 Transcript intron_variant - - - - - - IMPACT=MODIFIER;STRAND=1;BIOTYPE=protein_coding;NEAREST=ENSG00000183098 +rs34193955 13:94042801 A ENSG00000235784 ENST00000426409 Transcript downstream_gene_variant - - - - - - IMPACT=MODIFIER;DISTANCE=4429;STRAND=-1;BIOTYPE=processed_pseudogene;NEAREST=ENSG00000183098 +rs2543388 14:76629268 G ENSG00000089916 ENST00000261530 Transcript intron_variant - - - - - - IMPACT=MODIFIER;STRAND=1;BIOTYPE=protein_coding;NEAREST=ENSG00000089916 +rs2543388 14:76629268 G ENSG00000089916 ENST00000312858 Transcript intron_variant - - - - - - IMPACT=MODIFIER;STRAND=1;BIOTYPE=protein_coding;NEAREST=ENSG00000089916 +rs2543388 14:76629268 G ENSG00000089916 ENST00000554125 Transcript intron_variant,non_coding_transcript_variant - - - - - - IMPACT=MODIFIER;STRAND=1;BIOTYPE=retained_intron;NEAREST=ENSG00000089916 +rs2543388 14:76629268 G ENSG00000089916 ENST00000554375 Transcript intron_variant,NMD_transcript_variant - - - - - - IMPACT=MODIFIER;STRAND=1;BIOTYPE=nonsense_mediated_decay;NEAREST=ENSG00000089916 +rs2543388 14:76629268 G ENSG00000089916 ENST00000556663 Transcript intron_variant - - - - - - IMPACT=MODIFIER;STRAND=1;BIOTYPE=protein_coding;NEAREST=ENSG00000089916 +rs2543388 14:76629268 G ENSG00000089916 ENST00000557263 Transcript intron_variant - - - - - - IMPACT=MODIFIER;STRAND=1;BIOTYPE=protein_coding;NEAREST=ENSG00000089916 +rs117034934 15:96760479 G ENSG00000247809 ENST00000559505 Transcript intron_variant,non_coding_transcript_variant - - - - - - IMPACT=MODIFIER;STRAND=-1;BIOTYPE=antisense;NEAREST=ENSG00000205148 +rs117034934 15:96760479 G ENSG00000247809 ENST00000560800 Transcript intron_variant,non_coding_transcript_variant - - - - - - IMPACT=MODIFIER;STRAND=-1;BIOTYPE=antisense;NEAREST=ENSG00000205148 +rs77508211 16:54447249 A - - - intergenic_variant - - - - - - IMPACT=MODIFIER;NEAREST=ENSG00000177508 +rs9906524 17:4111727 A ENSG00000185722 ENST00000341657 Transcript intron_variant - - - - - - IMPACT=MODIFIER;STRAND=-1;BIOTYPE=protein_coding;NEAREST=ENSG00000185722 +rs9906524 17:4111727 A ENSG00000185722 ENST00000433651 Transcript intron_variant - - - - - - IMPACT=MODIFIER;STRAND=-1;BIOTYPE=protein_coding;NEAREST=ENSG00000185722 +rs9906524 17:4111727 A ENSG00000185722 ENST00000570535 Transcript intron_variant - - - - - - IMPACT=MODIFIER;STRAND=-1;BIOTYPE=protein_coding;NEAREST=ENSG00000185722 +rs9906524 17:4111727 A ENSG00000185722 ENST00000570934 Transcript intron_variant,non_coding_transcript_variant - - - - - - IMPACT=MODIFIER;STRAND=-1;BIOTYPE=retained_intron;NEAREST=ENSG00000185722 +rs9906524 17:4111727 A ENSG00000185722 ENST00000572412 Transcript intron_variant,NMD_transcript_variant - - - - - - IMPACT=MODIFIER;STRAND=-1;BIOTYPE=nonsense_mediated_decay;NEAREST=ENSG00000185722 +rs9906524 17:4111727 A ENSG00000185722 ENST00000573250 Transcript upstream_gene_variant - - - - - - IMPACT=MODIFIER;DISTANCE=300;STRAND=-1;BIOTYPE=retained_intron;NEAREST=ENSG00000185722 +rs9906524 17:4111727 A ENSG00000185722 ENST00000574367 Transcript intron_variant - - - - - - IMPACT=MODIFIER;STRAND=-1;BIOTYPE=protein_coding;NEAREST=ENSG00000185722 +rs78148126 18:63872801 G - - - intergenic_variant - - - - - - IMPACT=MODIFIER;NEAREST=ENSG00000071991 +rs722568 20:11285245 T ENSG00000230990 ENST00000444792 Transcript upstream_gene_variant - - - - - - IMPACT=MODIFIER;DISTANCE=3072;STRAND=-1;BIOTYPE=lincRNA;NEAREST=ENSG00000125899 +rs11089810 22:37323638 T ENSG00000100368 ENST00000262825 Transcript intron_variant - - - - - - IMPACT=MODIFIER;STRAND=1;BIOTYPE=protein_coding;NEAREST=ENSG00000100368 +rs11089810 22:37323638 T ENSG00000100368 ENST00000403662 Transcript intron_variant - - - - - - IMPACT=MODIFIER;STRAND=1;BIOTYPE=protein_coding;NEAREST=ENSG00000100368 +rs11089810 22:37323638 T ENSG00000100368 ENST00000406230 Transcript intron_variant - - - - - - IMPACT=MODIFIER;STRAND=1;BIOTYPE=protein_coding;NEAREST=ENSG00000100368 +rs11089810 22:37323638 T ENSG00000100368 ENST00000421539 Transcript intron_variant - - - - - - IMPACT=MODIFIER;STRAND=1;FLAGS=cds_end_NF;BIOTYPE=protein_coding;NEAREST=ENSG00000100368 +rs11089810 22:37323638 T ENSG00000100368 ENST00000536485 Transcript intron_variant - - - - - - IMPACT=MODIFIER;STRAND=1;BIOTYPE=protein_coding;NEAREST=ENSG00000100368 diff --git a/example_files/example.biomart b/example_files/example.biomart new file mode 100644 index 0000000..0b2c0b1 --- /dev/null +++ b/example_files/example.biomart @@ -0,0 +1,13 @@ +ENSEMBL_ID START END CHR GENE_NAME STRAND +ENSG00000069424 6051526 6161253 1 KCNAB2 1 +ENSG00000089916 76618259 76720685 14 GPATCH2L 1 +ENSG00000100368 37309670 37336491 22 CSF2RB 1 +ENSG00000105793 89964537 90020769 7 GTPBP10 1 +ENSG00000118193 200520628 200589862 1 KIF14 -1 +ENSG00000120594 20105168 20578785 10 PLXDC2 1 +ENSG00000133812 9800214 10315754 11 SBF2 -1 +ENSG00000139174 42852140 42984157 12 PRICKLE1 -1 +ENSG00000183098 93879095 95059655 13 GPC6 1 +ENSG00000183662 68053359 68594776 3 FAM19A1 1 +ENSG00000185619 699537 764428 4 PCGF3 1 +ENSG00000185722 4067201 4167274 17 ANKFY1 -1 diff --git a/example_files/example.intersections b/example_files/example.intersections new file mode 100644 index 0000000..ec22669 --- /dev/null +++ b/example_files/example.intersections @@ -0,0 +1,1002 @@ +category int_per_bp set_size +simulation 1.186044408467764e-06 12 +simulation 5.93022204233882e-07 12 +simulation 2.96511102116941e-07 12 +simulation 1.4825555105847051e-06 12 +simulation 8.895333063508231e-07 12 +simulation 2.96511102116941e-07 12 +simulation 8.895333063508231e-07 12 +simulation 2.96511102116941e-07 12 +simulation 5.93022204233882e-07 12 +simulation 5.93022204233882e-07 12 +simulation 1.4825555105847051e-06 12 +simulation 5.93022204233882e-07 12 +simulation 5.93022204233882e-07 12 +simulation 2.075577714818587e-06 12 +simulation 2.075577714818587e-06 12 +simulation 2.668599919052469e-06 12 +simulation 5.93022204233882e-07 12 +simulation 1.4825555105847051e-06 12 +simulation 2.372088816935528e-06 12 +simulation 8.895333063508231e-07 12 +simulation 2.96511102116941e-07 12 +simulation 1.7790666127016461e-06 12 +simulation 0.0 12 +simulation 1.186044408467764e-06 12 +simulation 2.075577714818587e-06 12 +simulation 2.96511102116941e-07 12 +simulation 1.186044408467764e-06 12 +simulation 1.4825555105847051e-06 12 +simulation 1.186044408467764e-06 12 +simulation 8.895333063508231e-07 12 +simulation 1.186044408467764e-06 12 +simulation 1.186044408467764e-06 12 +simulation 5.93022204233882e-07 12 +simulation 5.93022204233882e-07 12 +simulation 5.93022204233882e-07 12 +simulation 8.895333063508231e-07 12 +simulation 3.854644327520233e-06 12 +simulation 1.4825555105847051e-06 12 +simulation 2.96511102116941e-07 12 +simulation 5.93022204233882e-07 12 +simulation 1.186044408467764e-06 12 +simulation 5.93022204233882e-07 12 +simulation 5.93022204233882e-07 12 +simulation 5.93022204233882e-07 12 +simulation 1.4825555105847051e-06 12 +simulation 0.0 12 +simulation 1.4825555105847051e-06 12 +simulation 1.186044408467764e-06 12 +simulation 1.7790666127016461e-06 12 +simulation 5.93022204233882e-07 12 +simulation 8.895333063508231e-07 12 +simulation 2.9651110211694102e-06 12 +simulation 0.0 12 +simulation 1.4825555105847051e-06 12 +simulation 2.075577714818587e-06 12 +simulation 1.4825555105847051e-06 12 +simulation 5.93022204233882e-07 12 +simulation 1.4825555105847051e-06 12 +simulation 5.93022204233882e-07 12 +simulation 0.0 12 +simulation 1.186044408467764e-06 12 +simulation 8.895333063508231e-07 12 +simulation 2.96511102116941e-07 12 +simulation 8.895333063508231e-07 12 +simulation 1.186044408467764e-06 12 +simulation 8.895333063508231e-07 12 +simulation 5.93022204233882e-07 12 +simulation 8.895333063508231e-07 12 +simulation 1.186044408467764e-06 12 +simulation 0.0 12 +simulation 8.895333063508231e-07 12 +simulation 3.5581332254032923e-06 12 +simulation 5.93022204233882e-07 12 +simulation 2.96511102116941e-07 12 +simulation 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0.872 0.071