diff --git a/ci/deps/actions-310-minimum_versions.yaml b/ci/deps/actions-310-minimum_versions.yaml
index 9d7d23670df91..2be8a6a657364 100644
--- a/ci/deps/actions-310-minimum_versions.yaml
+++ b/ci/deps/actions-310-minimum_versions.yaml
@@ -26,7 +26,7 @@ dependencies:
 
   # optional dependencies
   - beautifulsoup4=4.12.3
-  - blosc=1.21.3
+  - blosc=1.21.6
   - bottleneck=1.3.6
   - fastparquet=2024.2.0
   - fsspec=2024.2.0
diff --git a/ci/deps/actions-310.yaml b/ci/deps/actions-310.yaml
index a7798ed41e3ba..491cb37d88d0c 100644
--- a/ci/deps/actions-310.yaml
+++ b/ci/deps/actions-310.yaml
@@ -24,7 +24,7 @@ dependencies:
 
   # optional dependencies
   - beautifulsoup4>=4.12.3
-  - blosc>=1.21.3
+  - blosc>=1.21.6
   - bottleneck>=1.3.6
   - fastparquet>=2024.2.0
   - fsspec>=2024.2.0
diff --git a/ci/deps/actions-311-downstream_compat.yaml b/ci/deps/actions-311-downstream_compat.yaml
index 9be72fc09dcba..13d18c6d4c9ea 100644
--- a/ci/deps/actions-311-downstream_compat.yaml
+++ b/ci/deps/actions-311-downstream_compat.yaml
@@ -25,7 +25,7 @@ dependencies:
 
   # optional dependencies
   - beautifulsoup4>=4.12.3
-  - blosc>=1.21.3
+  - blosc>=1.21.6
   - bottleneck>=1.3.6
   - fastparquet>=2024.2.0
   - fsspec>=2024.2.0
diff --git a/ci/deps/actions-311.yaml b/ci/deps/actions-311.yaml
index e3219f78a4ea7..c5fb7a87ba8f1 100644
--- a/ci/deps/actions-311.yaml
+++ b/ci/deps/actions-311.yaml
@@ -24,7 +24,7 @@ dependencies:
 
   # optional dependencies
   - beautifulsoup4>=4.12.3
-  - blosc>=1.21.3
+  - blosc>=1.21.6
   - bottleneck>=1.3.6
   - fastparquet>=2024.2.0
   - fsspec>=2024.2.0
diff --git a/ci/deps/actions-312.yaml b/ci/deps/actions-312.yaml
index 687b61d28fb94..0f553838f02b5 100644
--- a/ci/deps/actions-312.yaml
+++ b/ci/deps/actions-312.yaml
@@ -24,7 +24,7 @@ dependencies:
 
   # optional dependencies
   - beautifulsoup4>=4.12.3
-  - blosc>=1.21.3
+  - blosc>=1.21.6
   - bottleneck>=1.3.6
   - fastparquet>=2024.2.0
   - fsspec>=2024.2.0
diff --git a/ci/deps/circle-311-arm64.yaml b/ci/deps/circle-311-arm64.yaml
index 05ec5a084151c..7af5fe9b48bb9 100644
--- a/ci/deps/circle-311-arm64.yaml
+++ b/ci/deps/circle-311-arm64.yaml
@@ -24,7 +24,7 @@ dependencies:
 
   # optional dependencies
   - beautifulsoup4>=4.12.3
-  - blosc>=1.21.3
+  - blosc>=1.21.6
   - bottleneck>=1.3.6
   - fastparquet>=2024.2.0
   - fsspec>=2024.2.0
diff --git a/doc/source/getting_started/install.rst b/doc/source/getting_started/install.rst
index e40bbd6ceee47..35bfb9c85794e 100644
--- a/doc/source/getting_started/install.rst
+++ b/doc/source/getting_started/install.rst
@@ -305,7 +305,7 @@ Installable with ``pip install "pandas[hdf5, parquet, feather, spss, excel]"``
 Dependency                                             Minimum Version    pip extra        Notes
 ====================================================== ================== ================ ==========================================================
 `PyTables <https://github.com/PyTables/PyTables>`__    3.9.2              hdf5             HDF5-based reading / writing
-`blosc <https://github.com/Blosc/c-blosc>`__           1.21.3             hdf5             Compression for HDF5; only available on ``conda``
+`blosc <https://github.com/Blosc/c-blosc>`__           1.21.6             hdf5             Compression for HDF5; only available on ``conda``
 `zlib <https://github.com/madler/zlib>`__                                 hdf5             Compression for HDF5
 `fastparquet <https://github.com/dask/fastparquet>`__  2024.2.0           -                Parquet reading / writing (pyarrow is default)
 `pyarrow <https://github.com/apache/arrow>`__          10.0.1             parquet, feather Parquet, ORC, and feather reading / writing
diff --git a/pandas/compat/_optional.py b/pandas/compat/_optional.py
index 475572c1aafdd..e4a6a1b08c52c 100644
--- a/pandas/compat/_optional.py
+++ b/pandas/compat/_optional.py
@@ -23,7 +23,7 @@
     "adbc-driver-postgresql": "0.10.0",
     "adbc-driver-sqlite": "0.8.0",
     "bs4": "4.12.3",
-    "blosc": "1.21.3",
+    "blosc": "1.21.6",
     "bottleneck": "1.3.6",
     "fastparquet": "2024.2.0",
     "fsspec": "2024.2.0",
diff --git a/pyproject.toml b/pyproject.toml
index d930744afa6fe..4f7828f9e13cd 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -86,7 +86,7 @@ all = ['adbc-driver-postgresql>=0.10.0',
        'adbc-driver-sqlite>=0.8.0',
        'beautifulsoup4>=4.12.3',
        # blosc only available on conda (https://github.com/Blosc/python-blosc/issues/297)
-       #'blosc>=1.21.3',
+       #'blosc>=1.21.6',
        'bottleneck>=1.3.6',
        'fastparquet>=2024.2.0',
        'fsspec>=2024.2.0',