diff --git a/config/examples/stm32u5-nonsecure-dualbank.config b/config/examples/stm32u5-nonsecure-dualbank.config
index aa7ffeda1..9f0f1780a 100644
--- a/config/examples/stm32u5-nonsecure-dualbank.config
+++ b/config/examples/stm32u5-nonsecure-dualbank.config
@@ -23,3 +23,6 @@ WOLFBOOT_SECTOR_SIZE?=0x2000
 WOLFBOOT_PARTITION_BOOT_ADDRESS?=0x08010000
 WOLFBOOT_PARTITION_UPDATE_ADDRESS?=0x08110000
 WOLFBOOT_PARTITION_SWAP_ADDRESS?=0xFFFFFFFF
+
+# Use a larger image header size to enforce alignment requirements for the interrupt vector table
+IMAGE_HEADER_SIZE?=1024
diff --git a/config/examples/stm32u5.config b/config/examples/stm32u5.config
index bd8459f78..74d6ba77d 100644
--- a/config/examples/stm32u5.config
+++ b/config/examples/stm32u5.config
@@ -25,3 +25,6 @@ WOLFBOOT_PARTITION_UPDATE_ADDRESS?=0x817F000
 WOLFBOOT_PARTITION_SWAP_ADDRESS?=0x81FE000
 FLAGS_HOME=0
 DISABLE_BACKUP=0
+
+# Use a larger image header size to enforce alignment requirements for the interrupt vector table
+IMAGE_HEADER_SIZE?=1024
diff --git a/docs/Targets.md b/docs/Targets.md
index 28457a11d..0185f87ea 100644
--- a/docs/Targets.md
+++ b/docs/Targets.md
@@ -229,6 +229,10 @@ mon reset init
 
 ## STM32U5
 
+The STM32U5 is a Cortex-M33 (ARMv8-M).
+
+Note: We have seen issues with vector table alignment, so the default image header size (IMAGE_HEADER_SIZE) has been increased to 1024 bytes to avoid potential issues.
+
 ### Scenario 1: TrustZone Enabled
 
 #### Example Description